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Fostering Music Performers In The 21st Century: A Contemporary Professional Perspective Toward A New Curricular Agenda For Graduate Study In Music, Andre Januario

Graduate Theses, Dissertations, and Problem Reports (ETD)

What if the core curriculum for graduate students in music performance were designed to prepare students to succeed in the world of the Fourth Industrial Revolution?

This dissertation offers a hypothetical answer: a structured and systematic academic curricular framework for music graduate students of performance of concert music (especially those in terminal degrees, such as doctoral students), along with music instructors, professional music performers, school administrators, and college professors, seeking to prepare such students for achieving and maintaining a music career more in keeping with the current work environment, especially those skills demanded by the Fourth Industrial Revolution and the …

A Deep Learning Approach To Lncrna Subcellular Localization Using Inexact Q-Mer, Weijun Yi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Long non coding Ribonucleic Acids (lncRNAs) can be localized to different cellular components, such as the nucleus, exosome, cytoplasm, ribosome, etc. Their biological functions can be influenced by the region of the cell they are located. Many of these lncRNAs are associated with different challenging diseases. Thus, it is crucial to study their subcellular localization. However, compared to the vast number of lncRNAs, only relatively few have annotations in terms of their subcellular localization. Conventional computational methods use q-mer profiles from lncRNA sequences and then train machine learning models, such as support vector machines and logistic regression with the profiles. …

Design And Synthesis Of Targeted Immunotherapeutic Agents, Md Shohel Rana

Graduate Theses, Dissertations, and Problem Reports (ETD)

The therapeutic monoclonal antibodies are very important tools to fight against the diseases especially in the field of cancer immunotherapy. Many immunotherapeutic antibodies are being used to treat cancer that target multiple different components of the cancer microenvironment. Cells with extracellular juxtacrine ligands [JL-cells] and extracellular juxtacrine receptors [JR-cells] form JL-cell-JR-cell interfaces that produce juxtacrine signals inside JR-cells. [76] Juxtacrine signaling unlike endocrine or paracrine signaling requires no release or cellular uptake of ligands. [76] Immune checkpoint inhibitors are soluble IgG antibodies that block juxtacrine ligand engagements with juxtacrine receptors on tumor or other immune cells. [77] Rapid Nobel Prize …

Unique Biological Applications Of Charge Transfer Dissociation Mass Spectrometry, Halle M. Edwards

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ever-changing landscape of mass spectrometry is driven by gaps in knowledge, and one of the biggest driving forces is the desire to understand the structure and dynamics of biomolecules in living organisms. New and better methods of tandem mass spectrometry are often at the heart of technological developments. Some fragmentation methods are limited to expensive FTICR instruments, some techniques are limited multiply charged precursors, and others are limited to breaking only the weakest bonds in precursor ions; all of which support the pursuit of new activation methods. Charge transfer dissociation (CTD) addresses some of these concerns by providing structurally …

Online Ultra-High Performance Liquid Chromatography-Charge Transfer Dissociation-Mass Spectrometry (Uhplc-Ctd-Ms) Of Complex Mixtures Of Oligosaccharides, Praneeth M. Mendis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Online Ultra-High Performance Liquid Chromatography-Charge Transfer Dissociation-Mass Spectrometry (UHPLC-CTD-MS) of Complex Mixtures of Oligosaccharides

Praneeth M. Mendis

Complex carbohydrates make up more than half the biomass on earth, and they are crucial to a wide range of processes in living organisms. When polysaccharides and glycans are enzymatically digested into manageable units called oligosaccharides, they typically consist of 2-20 linear or branched sugar units. The detailed structural analysis of oligosaccharides assists in the identification of structural and chemical properties of the polymers from which they derive. Tandem mass spectrometry (MS/MS) is a key technique used in oligosaccharides structural characterization. Within …

Terrestrial Salamander And Ant Community Responses To Imidacloprid Application In Central Appalachian Eastern Hemlock Forests, Lenza E. Paul

Graduate Theses, Dissertations, and Problem Reports (ETD)

Imidacloprid is the most widely used insecticide in the world and has been found to impact non-target taxa in systems in which it is applied. It is used as the primary treatment method in the protection of eastern hemlocks (Tsuga canadensis) from impacts of hemlock woolly adelgid (HWA; Adelges tsugae), an invasive insect in the U.S. that is causing widespread mortality of hemlock trees. In this study, we investigated whether imidacloprid applied in eastern hemlock forests is impacting woodland salamander and ant communities.

In Chapter 1, I provide an overview of the ecological importance of eastern hemlocks …

Maternal Engineered Nanomaterial Inhalation Exposure: Cardiac Molecular Reprogramming In Progeny Through Epigenetic And Epitranscriptomic Mechanisms, Amina Kunovac

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Nano-titanium dioxide (TiO₂), a prominently utilized engineered nanomaterial (ENM), is being employed for its physiochemical properties in several fields including the food industry, manufacturing, and biomedicine. As the prevalence of this ENM, and other particulate matter grows, so does the concern for antagonistic consequences on long-term heart function in vulnerable populations, which until now have not been investigated. Due to the reliance of the heart on the ATP generating capacity of mitochondria for contraction, understanding the role of mitochondrial bioenergetics and structure is pivotal in understanding the repercussions of particulate matter exposure during gestation. As the mass …

Validation Of Shoulder Strain Index, Fabiha Islam

Graduate Theses, Dissertations, and Problem Reports (ETD)

Musculoskeletal disorders (MSDs) of shoulder are one of the most frequent and major causes of morbidity and pain among full-time workers in the USA. In 2018, shoulder disorders were the most severe type of MSDs in terms of lost workdays. Recent epidemiological studies have identified several biomechanical, organizational, and psychological factors that increase the risk of shoulder MSDs. Though multiple biomechanical studies have evaluated physical causal factors of shoulder MSDs with a goal of risk mitigation, literature lacks a standardized risk assessment tool. The main objective of this study was to validate a previously developed shoulder strain index. The strain …

Identical Twins As A Facial Similarity Benchmark For Human Facial Recognition, John Andrew Mccauley

Graduate Theses, Dissertations, and Problem Reports (ETD)

The problem of distinguishing identical twins and non-twin look-alikes in automated facial recognition (FR) applications has become increasingly important with the widespread adoption of facial biometrics. Due to the high facial similarity of both identical twins and look-alikes, these face pairs represent the hardest cases presented to facial recognition tools. This work presents an application of one of the largest twin datasets compiled to date to address two FR challenges: 1) determining a baseline measure of facial similarity between identical twins and 2) applying this similarity measure to determine the impact of doppelgangers, or look-alikes, on FR performance for large …

Assessing Synthetic Aperture Radar (Sar)-Derived Temporal Patterns And Digital Terrain Data For Palustrine Wetland Mapping, Jaimee L. Pyron

Graduate Theses, Dissertations, and Problem Reports (ETD)

Palustrine wetland systems are important ecosystems and provide numerous ecosystems services to support society. Unfortunately, they remain under constant threat of devastation due to land use practices and global climate change, which underscores the need to identify, map, and monitor these landscape features. This study explores harmonic coefficients and seasonal median values derived from Sentinel-1 synthetic aperture radar (SAR) data, as well as digital elevation model (DEM)-derived terrain variables, to predict palustrine wetland locations in the Vermont counties of Bennington, Chittenden, and Essex. Support vector machine (SVM) and random forest (RF) machine learning models were used with various combinations of …

Hands And Health: Quantifying Occupational Exposures And Implications Of Disability, Sueann R. Woods

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Hand grip strength (HGS) has been negatively correlated with both biologic, cognitive, and mental health markers. Aim one investigated how occupational metabolic equivalents (OMETs), impacted HGS. Aim two investigated lost time from work and the association with HGS. Finally, aim three investigated the health outcomes of workers’ compensation claimants who have lost time from work, following diagnosis of CTS.

Results:HGS was positively associated with OMET (rs = 0.078, p = 0.009). Linear regression model demonstrated a statistically significant association between HGS and OMETs, F(1, 31) = 9.735, p = .001. Aim two found that all occupation groups had …

Psychometric Evaluation Of Genetic Literacy Instruments In A National Sample, Jamey T. Brumbaugh

Graduate Theses, Dissertations, and Problem Reports (ETD)

The concept of genetic literacy continues to grow in clinical and social significance. Whether transforming current healthcare practices or raising questions about genetically-modified foods, genetic information and technologies are primed to further influence people’s lives. There is a growing need to understand how genetic literacy is currently assessed in order to inform and improve future test development. This study aimed to investigate the assessment of genetic literacy by psychometrically examining three contemporary genetic literacy instruments (i.e., Genetic Knowledge Survey, International Genetic Literacy and Attitudes Survey (iGLAS-GK), and University of North Carolina Genomic Knowledge Scale (UNC-GKS). Psychometric properties, including internal consistency …

Effects Of Biofertilizer On Soil Nutrient Cycling And The Productivity Of Bioproduct Crops In Marginal Soils, Kieran B. Liseski

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recently there has been increased interest in the use of marginal lands in order to grow bioproduct crops. Utilizing marginal lands to grow bioproduct crops such as Miscanthus x giganteus and Panicum virgatum could not only improve soil quality and minimize negative environmental impacts on the surrounding ecosystems but could also offer economic benefits to growers in rural areas. Because marginal soils tend to reduce crop yields compared to prime farmlands even when growing bioproduct crops, which tend to be more robust than traditional food crops, augmenting the soil with biofertilizers (i.e., the direct addition of viable microbial cells) could …

Examining Relationships Among Person Factors, Psychosocial Factors, And Coping Patterns In People Living With Type 2 Diabetes Mellitus In North Central Appalachia, Melissa A. Mccoy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Diabetes is a complex, debilitating illness that imposes disease burden on the individual and society. T2DM is more prevalent in the Appalachian region than in any other Region of the United States. If diabetes is poorly controlled, patients are at risk for negative health outcomes. A gap exists in the literature related to understanding of the relationships among person factors, psychosocial factors, and coping patterns. Another gap in the literature is sex differences among these variables.

Purpose: The purpose of this study is to examining relationships among person factors, psychosocial factors, and coping patterns in people living with T2DM …

Insect Community Associated With Black Cherry (Prunus Serotina) In The Allegheny National Forest, Craig James Larcenaire

Graduate Theses, Dissertations, and Problem Reports (ETD)

Black cherry (Prunus serotina Ehrh.) is valuable species managed for its economic and ecologic benefits. This species grows best in the environment of the Allegheny Plateau region in northwestern Pennsylvania. Land managers on the Allegheny National Forest (ANF) have been managing black cherry for a variety of goals and purposes. Over the last few decades, the land managers have noticed a decline in the natural regeneration of black cherry in the forest. Because the black cherry flowers are self-incompatible and require animal pollinators to transfer the pollen from one tree to another one hypothesis for this decline could be …

A Survey Of Musical Expectations In The Marine Forces Reserve Band Stationed In New Orleans, Louisiana, Brandon Paul Carbonari

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research document examines the musical expectations of United States Marines serving in the Marine Forces Reserve Band from 2017 to 2021. Chapter One of this study provides a detailed foundation of the musical and non-musical responsibilities of a United States Marine musician. Training regime, rehearsal schedule, and logistical area responsibilities will be described to help convey the full scope of duty. The source material for Chapter One includes dissertations, journal articles, published books, online sources, and interviews. Chapter Two provides results of a survey that was conducted with members of the band. The questions were designed to record the …

Improving Broiler Performance And Digestibility Through Feed Enzymes And Production Rate Aids Utilized In Pelleting., Kristina Marie Bowen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Enzymes are commonly added to poultry diets to improve performance parameters that may in turn decrease costs to the producer. Pellet mill production rate aids are also utilized to reduce feed manufacture costs and may have additional benefits when fed to poultry that are associated with the increase in production rate. Past research has shown that Azomite (AZM) can increase pellet mill production rate in diets that include inorganic phosphate sources (IPS) of dicalcium phosphate (DCP) or tricalcium phosphate (TCP). In the first experiment the authors hypothesized that if production rate were held constant then pellet mill energy consumption would …

Sustainability Assessment Of Direct Energy Deposition (Ded) Based Hybrid Manufacturing Using Life Cycle Assessment (Lca) Method, Faujia Islam

Graduate Theses, Dissertations, and Problem Reports (ETD)

As sustainability has emerged as a highlight for almost every field over the last few decades, the manufacturing field is no exception. Generally, additive manufacturing performs better than traditional manufacturing in terms of sustainability because of its lean energy- and material usage. Previous studies have compared the sustainability performance between traditional and additive manufacturing, but hybrid manufacturing was not focused upon much. In this paper, the life cycle assessment method is used to analyze and compare the energy consumption and environmental impact of direct energy deposition (DED) based hybrid manufacturing and traditional manufacturing “CNC milling” process for a turbine blade. …

Effects Of Multiple Stressors On Aquatic Macroinvertebrate Communities In A Mixed-Land-Use Watershed, Joellen Stivala

Graduate Theses, Dissertations, and Problem Reports (ETD)

As urbanization continues, there is a need to identify and understand environmental stressors that impact stream condition in mixed-land-use watersheds. This study analyzed four years of aquatic macroinvertebrate community and environmental data collected from ten sites located at the mouths of first-order tributaries and along the main stem creek of a 23-km², mixed-land-use watershed in central Appalachia. The main objectives were to 1) determine stream ecological integrity by analyzing stream macroinvertebrate taxonomic and trait-based composition and 2) assess which of 23 environmental variables explained significant variability in common community composition metrics (WVSCI, GLIMPSS, Biotic Index, % clingers, etc.). …

The Origin Of Novel Trait Inferred From Transcriptomic Analysis And A Targeted Gene Approach In The Beetle Horns., Naureen Fatima

Graduate Theses, Dissertations, and Problem Reports (ETD)

The origin of the evolutionary new trait (evolutionary novelty) and its subsequent evolution is of great interest for biologists in various fields, and beetle horns have been used to address this fundamental biological question. Previous studies on one of the horned beetle species, Onthophagus taurus, that utilized comparative gene expression analyses, suggested legs to be a strong candidate of the origin of horns. At the same time, their horns are secondary sexual traits whose development is regulated by the same gene (doublesex) as genitalia, which also originates from paired appendages such as legs. However, little is known …

Examining The Effects Of Background Noise On Contextualized Word Learning, Caitlin Alyssa Ross

Graduate Theses, Dissertations, and Problem Reports (ETD)

Despite redundancy in the acoustic speech signal, both children and adults demonstrate difficulty listening and learning in noise. Research has shown that the acoustic parameters of classrooms and common study places, such as libraries and coffee shops, are often exposing students daily to unhealthy levels of background noise and distraction as they attempt to access and retain new information. While younger children may encounter new words via deliberate instruction in a classroom setting, older students are more likely to access new vocabulary indirectly via reading or self-study in noisy environments often of their own choosing. In both scenarios, accurate perception …

Environmental Contaminants, Parasitism, And Neoplasia In White Perch Morone Americana From Chesapeake Bay, Usa, Mark Arnold Matsche

Graduate Theses, Dissertations, and Problem Reports (ETD)

White perch are an abundant demersal fish species in freshwater and oligohaline habitats of the Chesapeake Bay. An avoidance of salinity > 12-15 ppt generally restricts the distribution and movements of fish to within tributaries in the mid to lower Bay, which over time has resulted in the formation of at least three separate stocks in Chesapeake Bay. Sub-populations of white perch that are partially isolated may serve as sentinels of the conditions or stressors in the tributaries in which they reside. Fish are exposed to a variety of environmental contaminants and other anthropogenic stressors that can vary in magnitude based …

Solution Tool To Predict Filter Cake Formation For Acid Mine Drainage (Amd) Slurries, Roberto Ecuador Martinez Ochoa

Graduate Theses, Dissertations, and Problem Reports (ETD)

Acid Mine Drainage (AMD), also known as alkaline mine drainage resulted from abandoned and active coal mining areas has been a major water pollutant in the mid-Atlantic region of the United States affecting aquatic life, recreational areas, tourism, etc. AMD results from during and post mining activities all around the US and the world containing high levels of acidic materials such as sulfate and other heavy metals.

The United States Environmental Protecting Agency (EPA) has recommended the use of different mechanisms for mitigation purposes due to considerable existing and potential damage generated by AMD. This report focuses on the usage …

The 2014 West Virginia Elk River Chemical Leak: A Case Study Of Respiratory Health Disparities And Drinking Water Contamination, Maya Nye

Graduate Theses, Dissertations, and Problem Reports (ETD)

This case study supplements existing data with original analysis to address environmental pollution burden and health effects not previously examined from the 2014 Freedom Industries Elk River chemical leak in West Virginia. Comparisons were made between the peer-reviewed literature, governmental disaster management practices implemented during the leak, and alternative human health assessment models to determine whether the evidence relied upon for decision-making was adequate for protecting public health, minimizing health disparities and increasing health equity. An emphasis was placed on understanding how the state and federal government approached human health hazard assessment and health outcome reporting, particularly of socially vulnerable …

Adolescent Adventures In Geology: Impacts Of Geoscience-Focused Stem Education Combined With Recreation Activities On Adolescents’ Perceived Self-Efficacy, Lauren Janowicz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Quality, informal learning techniques combined with outdoor adventure recreation, or adventure STEM programming, is a potentially powerful complement to and extension of formal education (Fu et al., 2015). To address this underexplored field, West Virginia University (WVU) and the United States Geological Survey (USGS) partnered to create a geology STEM, outdoor adventure recreation camp. This thesis research project employed qualitative directed content analysis to examine the potential impacts of this adventure STEM program on participants’ perceptions of their outdoor recreation (OR) self-efficacy (Bandura, 1994; Mittelstaedt et al., 2009). Semi-structured interviews were conducted with 15 adolescent participants with an average age …

Predictors Of Cardiovascular And Gastrointestinal Disorders, Inappropriate Nonsteroidal Anti-Inflammatory Drug Use, And Alzheimer’S Disease And Related Dementia In Older Adults With Osteoarthritis, Jayeshkumar Patel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Osteoarthritis (OA) is a degenerative arthritis affecting over 30 million Americans most of whom are over 65 years or older. Its clinical management is complicated by several disease- and treatment-specific factors. These include the co-occurrence of cardiovascular and gastrointestinal disorders (CV-GID), the inappropriate use of non-steroidal anti-inflammatory drugs (NSAID) to manage pain, and the risk of certain age-related chronic conditions like Alzheimer’s disease and related dementia (ADRD). Moreover, older adults with OA are at a higher risk of CV-GID, inappropriate NSAID use, and ADRD. Additionally, these factors can also affect one another in both a positive and a negative way. …

Targeting The Nt17 Of The Huntingtin Protein Via Natural And Chemical Modifications: Impact On Aggregation And Membrane Interactions, Faezeh Sedighi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Huntington Disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine domain (polyQ) in the first exon of the huntingtin protein (htt-exon1). The major hallmark of HD is the accumulation of aggregates into proteinaceous inclusion bodies. PolyQ expansion in huntingtin promotes self-assembly into a variety of toxic aggregates such as oligomers, fibrils, and amorphous aggregates. The resulting heterogeneous mixture of distinct species makes it difficult to assign a toxic function to specific aggregate structures. In addition, htt interacts with a variety of membranous surfaces. The first 17 amino acids (Nt17) of htt directly flanking the polyQ domain functions …

Haemonchus Contortus Antigen Identification And Use Of Tropomyosin In Ovine Vaccine Development, Brynnan P. Russ

Graduate Theses, Dissertations, and Problem Reports (ETD)

Globally, the small ruminant industry loses hundreds of millions of dollars due to parasitism by the gastrointestinal nematode Haemonchus contortus. This parasite feeds on blood in the host’s abomasum leading to disease including anemia, hypoproteinemia, lethargy, and death. There have been exhaustive efforts to manage this parasite including different management applications, anthelmintic treatment, and now integration of resistance genetics into a flock. Like antibiotics, overuse of anthelmintics has led to resistance of H. contortus to these drugs. Therefore, other methods of control are the main focuses of many research initiatives. St. Croix are a resistant breed of sheep that mount …

"We Have Ground To Cover For Each Other": A Case Study Of Mentoring Across Black Sorority Alumni In North Central West Virginia, Elizabeth C. Dever

Graduate Theses, Dissertations, and Problem Reports (ETD)

Black sororities are much more than their stereotypes of stepping and partying. They are service organizations that have a deep impact on their communities and help shape the identities of their members. These organizations can be seen at Historically Black Colleges and Universities (HBCUs) and Predominately White Institutions (PWIs). Black sororities are different than their traditionally white counterparts because the majority of active time in membership occurs after graduation. This thesis utilizes a case study of Black sororities in North Central West Virginia and West Virginia University. In spaces lacking in diversity and inclusion, Black sororities can serve as a …

Frontal Brain Injury: Effects On Flexibility, Impulse Control, And Attention, Christopher Matthew O'Hearn

Graduate Theses, Dissertations, and Problem Reports (ETD)

Traumatic Brain Injury (TBI) is defined as an impact to the head, penetration of the skull, or rapid deceleration of the skull, resulting in an alteration of brain function or neurological deficit. Cognitive deficits are common following TBI and often go unresolved due to a lack of effective treatments. These deficits often perseverate into the chronic post injury phase, so the development of rehabilitative strategies is imperative. Behavioral flexibility, impulse control, and attention are a few cognitive processes that are commonly affected by TBI. The current research compares these processes between rats with and without a severe frontal brain injury …