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Graduate Theses, Dissertations, and Problem Reports (ETD)

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Metallothionein Gene Expression In Human Breast Cancer, Volkan Gurel Aug 2003

Metallothionein Gene Expression In Human Breast Cancer, Volkan Gurel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Metallothioneins (MT) are a family of low molecular weight (6 kDa) cysteine rich proteins that participate in a variety of functions such as detoxification of heavy metals and homeostasis of essential metals. They can also act as scavengers of free radicals. MT-1 and 2 isoforms are ubiquitously expressed, whereas the expression of the third isoform is limited to the neural tissue. In the PC-3 prostate cancer cell line, MT-3 expression has been shown to inhibit cell growth and increase drug resistance. The goal of the present study was to determine if MT-3 overexpression would influence the growth of human breast …

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Treatment Outcome For Male Adolescents In Residential Placement, Taji Tortorello Aug 2003

Treatment Outcome For Male Adolescents In Residential Placement, Taji Tortorello

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of the study was to assess archival data to determine what variables are related to successful discharge from a residential treatment program for adolescents with behavioral disorders. The records of 120 residents of a Northern Virginia residential treatment program were reviewed from January 1999 to January 2001. The researcher was interested in determining what predictor variables, such as: intake demographic and intake assessments relate to outcome, such as: discharge assessments, discharge planning, and discharge GPA. Results indicated that students who are successfully discharged from this program at intake are typically: (1) older, (2) less oppositional, (3) engage in …

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Gene Expression Profiling In Prepubertal And Adult Male Mice Using Cdna And Oligonucleotide Microarrays, Lisa Marie Tomascik-Cheeseman May 2003

Gene Expression Profiling In Prepubertal And Adult Male Mice Using Cdna And Oligonucleotide Microarrays, Lisa Marie Tomascik-Cheeseman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Variations in gene expression are the basis of differences in cell and tissue function, response to DNA damaging agents, susceptibility to genetic disease, and cellular differentiation. The purpose of this dissertation research was to characterize variation in basal gene expression among adult mouse tissues for selected stress response, DNA repair and damage control genes and to utilize variation in temporal gene expression patterns to identify candidate genes associated with germ cell differentiation from mitosis through meiosis in the prepubertal mouse testis. To accomplish these goals, high throughput analyses of gene expression were performed using custom cDNA and random oligonucleotide microarrays. …

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Molecular Cytogenetic Evaluation Of Uveal Melanoma Cell Lines And Archival Tissue, Jason Scott White May 2003

Molecular Cytogenetic Evaluation Of Uveal Melanoma Cell Lines And Archival Tissue, Jason Scott White

Graduate Theses, Dissertations, and Problem Reports (ETD)

Uveal melanoma is the most common intraocular tumor in adults and often results in unilateral blindness and/or death. Previous cytogenetic characterizations of this tumor have consistently revealed chromosomal abnormalities involving chromosomes 3, 6, and 8; reports of other abnormalities vary in frequency. We further defined cytogenetic abnormalities of this tumor using molecular cytogenetic techniques on 10 uveal malignant melanoma cell lines and 100 formalin-fixed paraffin-embedded (FFPE) tumors.;The synthesis of comparative genomic hybridization (CGH) and spectral karyotyping (SKY) results revealed that chromosomal rearrangement plays a significant role in the generation of DNA sequence copy number abnormalities throughout the genome, but none …

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Correlation Of The Use Of Computers By Education Faculty With National Standards For Preservice Students, Robin T. Twery May 2003

Correlation Of The Use Of Computers By Education Faculty With National Standards For Preservice Students, Robin T. Twery

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this research study was to provide information to faculty, administrators and state departments of education about the level of integration of computer technology into teacher education programs. The stated problem of this research was to determine the correlation of the use of computers by education faculty with national standards for preservice teachers. A review of the literature identified the continuing growth of computer use and a growing acceptance of national standards for computer literacy in K--12 and higher education settings. To determine the extent of computer use among education faculty, a three-part survey was developed. It including …

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Pyxidis Echo Lacuna, Jessica Mai Weathersby May 2003

Pyxidis Echo Lacuna, Jessica Mai Weathersby

Graduate Theses, Dissertations, and Problem Reports (ETD)

The intention of the work that supports this thesis is to provide a space for the viewer to suspend the exterior world and move into a space where he or she finds a line of questioning and a cyclic experience that ultimately leads to self-reflection. The microcosm and macrocosm enlarged and reduced, respectively, to human scale, allow one to experience this phenomenon in conversational dialog. By conflating the limits of the universe, the participant becomes omniscient within this configuration of large printed works on paper. Texture, line and variant translucent color provides the viewer with a multi-sensory experience. Interaction of …

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Telecommunication Of Stabilizing Signals In Power Systems, Guillaume Julien Raux May 2003

Telecommunication Of Stabilizing Signals In Power Systems, Guillaume Julien Raux

Graduate Theses, Dissertations, and Problem Reports (ETD)

Deregulation of the power industry has occurred at a rapid pace, opening some promising competition between suppliers. The result of this competition should be to the benefit of customers.;Telecommunication plays a crucial role in integrating systems and ensuring smooth operation by way of exchanging data and information between various systems that are responsible for monitoring and control of the grid. For example, a Power System Stabilizer (PSS) controller could be placed at one of the generators and requires remote measurements. All the communication schemes within the network generate delays that are characterized in this project using OPNET Modeler. OPNET Modeler …

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Evaluating The Cost-Effectiveness Of St. John's Wort Versus Fluoxetine For The Treatment Of Mild To Moderate Depression, Lee Ann Thayer May 2003

Evaluating The Cost-Effectiveness Of St. John's Wort Versus Fluoxetine For The Treatment Of Mild To Moderate Depression, Lee Ann Thayer

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this study was to determine the cost-effectiveness of St. John's Wort compared to fluoxetine from a third party perspective for the treatment of mild to moderate depression. Fluoxetine 20 mg daily was compared to St. John's Wort 300 mg thrice daily in a decision tree modeling depression management in the outpatient setting. Probabilities were obtained from a Medline search as well as input from an expert panel. Direct medical costs were obtained from medical offices in the Connecticut area with drug and herb cost based on 2002 published data. Several sensitivity analyses were performed. The cost-effectiveness ratio …

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Studies On The Effects Of Propanil On Macrophage Function And Signaling, Laura Lynn Frost May 2003

Studies On The Effects Of Propanil On Macrophage Function And Signaling, Laura Lynn Frost

Graduate Theses, Dissertations, and Problem Reports (ETD)

Propanil has been shown to induce numerous manifestations of impaired immune responses. This dissertation focuses on the effects of propanil on TNF-alpha production and NFB activation in murine and human macrophages in response to LPS stimulation. Initial studies demonstrated that propanil treatment of the murine peritoneal macrophage cell line, IC-21 resulted in decreased NF-kappaB activation and transcriptional activity as determined by Western blot and NF-kappaB-dependent reporter gene transcription, respectively. Nuclear localization of NF-kappaB was also shown to be decreased by immunofluorescence. Additional studies to confirm these effects in the human cell line, THP-1 also showed decreased nuclear levels of NF-kappaB …

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Regulation Of P-Glycoprotein And Abcp Transporters, Dhanashri Ramkrishna Kolwankar May 2003

Regulation Of P-Glycoprotein And Abcp Transporters, Dhanashri Ramkrishna Kolwankar

Graduate Theses, Dissertations, and Problem Reports (ETD)

The placenta plays an important role in modulating xenobiotic passage from mother to fetus. Smoking is known to induce cytochrome P450 1Al (CYP1A1) expression in the placenta, however its effect on P-glycoprotein (P-gp) and ABC transporter in placenta (ABCP) levels in placenta is not known. In-vitro studies in hepatocytes have reported induction of P-gp mRNA by some polycyclic aromatic hydrocarbons. To examine whether smoking can affect placental P-gp and ABCP, their expression and activity were determined in placentas from smokers and non-smokers. Uptake of [3H]-vinblastine and [3H]-mitoxantrone was used to measure P-gp and ABCP function, respectively and CYP1A1 activity (positive …

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Study On Candle Filter Surface Regeneration Characteristics At Room Temperature, Venkatesh Vasudevan May 2003

Study On Candle Filter Surface Regeneration Characteristics At Room Temperature, Venkatesh Vasudevan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ceramic barrier filtration is a leading technology employed in hot gas filtration. The deposited ash on these filters is removed by a process known as surface regeneration. The objective of this research has been to utilize the room temperature testing facility (RTTF), to study the surface regeneration process at room temperature. The face velocity of the fluidized gas, the regeneration pressure of the back pulse and the time to build up ash on the surface of the candle filter were identified as the important parameters to be studied. Two types of ceramic candle filters were used in the study. The …

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Effects Of Bit Geometry In Multiple Bit-Rock Interaction, Rizwan Ahmad Qayyum May 2003

Effects Of Bit Geometry In Multiple Bit-Rock Interaction, Rizwan Ahmad Qayyum

Graduate Theses, Dissertations, and Problem Reports (ETD)

The impact of bit-coal/rock interaction during the cutting process in underground mines is great concern to the mining community of the world. Rock/coal cutting bears directly on rock/coal dust generation that causes "black lung/silicosis" in miners. On the other hand, rock cutting generates radiance of sparks that has potential to cause face ignition. Bit wear affects productivity, safety and economy. Hundreds of face ignitions and millions of dollars in productivity and compensation for respirable rock/coal dust related diseases are attributed to the cutting action of continuous miners/shearers. These undesirable impacts could be minimized by proper selection of bit types, bit …

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Development Of A Test Facility To Evaluate Hot Gas Filtration Characteristics Of A Candle Filter, Juan Pablo Rincon May 2003

Development Of A Test Facility To Evaluate Hot Gas Filtration Characteristics Of A Candle Filter, Juan Pablo Rincon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hot gas particulate filtration is a basic component in advanced power generation systems such as Integrated Gasification Combined Cycle (IGCC) and Pressurized Fluidized Bed Combustion (PFBC). These systems require effective particulate removal to protect the downstream gas turbine and also to meet environmental emission requirements. The ceramic barrier filter is one of the options for hot gas filtration. Hot gases flow through ceramic candle filters depositing ash on the outer surface of the filter. After this cleaning process there may be some residual ash remaining on the filter surface. This residual ash layer may grow after many cycles of filtering, …

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Performance Evaluation Of Diesel Particulate Filters On Heavy-Duty Vehicles, Stephen George Rosepiler May 2003

Performance Evaluation Of Diesel Particulate Filters On Heavy-Duty Vehicles, Stephen George Rosepiler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Diesel particulate filters, or DPFs, are exhaust aftertreatment devices used to reduce exhaust emissions from diesel powered vehicles. Typical designs have a wall flow filter element downstream of an oxidation catalyst, which oxidizes a portion of the NO present in the exhaust stream to form NO2. The resulting NO2 aides in the combustion of the soot collected in the wall flow filter element allowing for the complete breakdown of the soot within typical diesel exhaust temperatures, thus limiting the required maintenance on the filter elements to the removal of non-combustible ash.;Three aspects of DPF performance were investigated: cold start performance, …

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Loss Count, Sonya Corin Russomanno May 2003

Loss Count, Sonya Corin Russomanno

Graduate Theses, Dissertations, and Problem Reports (ETD)

My prints encompass themes of loss of past experiences, poetics, repetition, and feeling. By remembering facts from past experiences, one can recall how a particular moment felt. My intention when producing a piece of work is to generalize themes of loss, time, and memory by using visual features of pattern, space, and repetition of forms to exemplify feelings in relation to loss, time, and memory. This thesis statement will first address themes of loss, time, memory, and the visual devices that are employed with one intention, that they exemplify features crucial in my work. In addition, I will address the …

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Comparison Of Concentrations In The Breathing Zone, Santosh Raghavendra Kulkarni May 2003

Comparison Of Concentrations In The Breathing Zone, Santosh Raghavendra Kulkarni

Graduate Theses, Dissertations, and Problem Reports (ETD)

The concentrations in the "breathing zone" were analyzed on three human subjects in simulating work conditions. The experiments were carried out in a wind tunnel having 40&feet; x 12&feet; x 9&feet; dimensions. Ethanol vapor mixed with nitrogen was used as a tracer gas. Samples were taken at the forehead, adjacent to the nose (nose), the mouth, neck, chest, right lapel, left lapel. Nose was sampled at l liter per minute (lpm) and 0.15 lpm at different times, while the others were sampled at 0.15 lpm at two different wind tunnel velocities. The source was released at naval height for each …

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Application Of Statistical Methods For "Flow Unit" Identification And Characterization Of A Reservoir Using Well Log And Core Data, Reza Mustafa May 2003

Application Of Statistical Methods For "Flow Unit" Identification And Characterization Of A Reservoir Using Well Log And Core Data, Reza Mustafa

Graduate Theses, Dissertations, and Problem Reports (ETD)

A flow unit is a stratigraphically continuous interval of similar reservoir process speed that maintains the geologic framework and characteristics of rock types. Permeability and porosity of the reservoir rock has always been considered as two of the most important parameters to identify flow unit for formation evaluation, reservoir description, and characterization. Beyond evaluating permeability and porosity, one can also use combinations of two or more rock properties to gain insight into the character of two through porous media. Porosity is commonly evaluated from the well log data, which are usually available from the most wells in the reservoir. But …

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Elite And Non-Elite Sourcing In Civic And Traditional Journalism News Projects, Jennifer M. Roush May 2003

Elite And Non-Elite Sourcing In Civic And Traditional Journalism News Projects, Jennifer M. Roush

Graduate Theses, Dissertations, and Problem Reports (ETD)

This project consists of two studies used to analyze "elite," media-savvy, and "non-elite," non-media savvy, sources in civic and traditional journalism. For the first study, four newspaper series about mining and aging, 22 articles total, examined source use in the practice of civic journalism. The results for the mining comparison were significant; however, the results for the aging comparison were not significant. For the second study, the writers and editors of the news projects, and other journalism professionals were interviewed to determine the cause of the mixed significance. The interviews revealed the intentions of the civic writers were not the …

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Measurement Of Attitude Toward Educational Use Of The Internet In An English Composition Course With A Comparison Of Traditional -Aged And Non-Traditional-Aged Students, Diana Gail Duran May 2003

Measurement Of Attitude Toward Educational Use Of The Internet In An English Composition Course With A Comparison Of Traditional -Aged And Non-Traditional-Aged Students, Diana Gail Duran

Graduate Theses, Dissertations, and Problem Reports (ETD)

Attitude is tied to behavior, and writing behaviors seem to be affected by using a computer. Technological advances have forever changed the way educators view the process of writing, including the way students learn, how they feel about the way they are learning, and their subsequent behaviors. Numerous studies have indicated that using computers to write changes the way students write, what they write, and the quantity and quality of that writing. However, studies disagreed about how these changes occur, whether they are positive or negative (or neither), and what psychological dynamics, such as attitude, are involved, to what degree, …

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Reinforcement And Punishment During Programmed Instruction, Stephen C. Scherer May 2003

Reinforcement And Punishment During Programmed Instruction, Stephen C. Scherer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recommendations for improving answer accuracy during programmed instruction have included the use of punishment to decrease the rate of students' responding and to prevent careless mistakes. The effects of punishment during programmed instruction, however, have not been clearly identified. There is evidence that punishment increases attention and decreases response rates during learning tasks, but other effects on student responding, including escape from the learning task, have not been systematically examined. The present study was designed to systematically examine the effects of punishment as well as extinction during programmed instruction. Four college students were recruited to earn money while working on …

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Geological Mapping Of Entry Roof In Mines, Quanzhong Gu May 2003

Geological Mapping Of Entry Roof In Mines, Quanzhong Gu

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although strata types and approximate thickness of strata can be obtained from the geological exploration materials of the mine, these do not meet the requirements for roof bolting design because of the ever-changing roof geological properties, including rock strength, discontinuity distribution, and thickness of rock strata. In order to obtain such geological information in a timely manner, the technology of geological mapping of the roof in the mine, which uses the drilling parameters acquired during the drilling process, has been proposed. The study in this dissertation attempts to map the roof geology by developing a new drilling parameter, drilling hardness, …

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Implementation And Application Of Nde On Ceramic Candle Filters, Alejandro C. Kiriakidis May 2003

Implementation And Application Of Nde On Ceramic Candle Filters, Alejandro C. Kiriakidis

Graduate Theses, Dissertations, and Problem Reports (ETD)

A nondestructive evaluation (NDE) technique has been developed to determine the deterioration and remaining life of full-size ceramic candle filters used at the Power System Development Facility (PSDF) in Alabama. Ceramic candle filters are hollow cylindrical structures made of porous ceramic materials used in advanced coal-fired power generation systems. They protect power plant's gas turbine components from damage due to erosion. In general, advanced coal-fired power systems operational conditions include extreme thermal/pressure environment and vibration-induced stresses over a great period of time. The knowledge of the dynamic behavior of ceramic candle filters is essential and can be used to measure …

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Linear Expansion Of Dental Stone After Its Final Set And Beyond Two Hours, Marcos Cid Galano May 2003

Linear Expansion Of Dental Stone After Its Final Set And Beyond Two Hours, Marcos Cid Galano

Graduate Theses, Dissertations, and Problem Reports (ETD)

When accuracy and strength are required in fabricating working casts improved dental stones are recommended. The main variable affecting this accuracy is linear setting expansion. In this research study the linear setting expansion of three commonly used improved dental stones were compared over an extended 2-week period. Hard Rock, Silky Rock and Prima-Rock were vacuum mixed following manufacturers instructions. Five specimens of each stone were measured for linear expansion using a SAM EMI100 Expansion measuring Device. Expansion measurements were made at 10 and 30 minutes, 2, 24, 48, 72, and 120 hours. The gathered data were subjected to a two …

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Dapsone Activation Of Cyp2c9 Allelic Variants, Matthew Aaron Hummel May 2003

Dapsone Activation Of Cyp2c9 Allelic Variants, Matthew Aaron Hummel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Studies have shown that CYP2C9.1 mediated metabolism of flurbiprofen and naproxen is activated by dapsone. However, dapsone activation has not been studied in the allelic variant forms of CYP2C9. Six concentrations of flurbiprofen or naproxen were co-incubated with six concentrations of dapsone and with reconstituted, purified CYP2C9.1, CYP2C9.2 (R144C), CYP2C9.3 (1359L), or CYP2C9.5 (D360E), in order to assess degrees of activation. Dapsone increased the efficiency (Vmax/Km) of flurbiprofen metabolism 690%, 3029%, 4600%, and 2100% by CYP2C9.1, CYP2C9.2, CYP2C9.3, and CYP2C9.5, respectively. Dapsone increased the efficiency of naproxen metabolism 591%, 1400%, 1150%, and 2100%, by CYP2C9.1, CYP2C9.2, CYP2C9.3, and CYP2C9.5, respectively. …

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Cytogenetic Analysis Of Primary Breast Tumors And Mcf10a Cells To Determine Early Steps Of Breast Carcinoma, Mohammad Mah Odetallah May 2003

Cytogenetic Analysis Of Primary Breast Tumors And Mcf10a Cells To Determine Early Steps Of Breast Carcinoma, Mohammad Mah Odetallah

Graduate Theses, Dissertations, and Problem Reports (ETD)

Breast cancers are characterized by genomic instability, abnormal chromosomal counts and multiple translocations. There is a heavy burden on tumor cells to acquire as many mutations as possible in a short time. Tumors seem to achieve that through genomic instability. The role of homologous recombinational repair loss has been well established as a mechanism of chromosomal instability. A researcher at the University of Pittsburgh, Dr. Jean Latimer, was able to demonstrate the loss of nucleotide excision repair (NER), in adjacent non tumor tissue. NER functions in bulky adducts repair, following UV radiation. These lesions introduce a bend in the DNA …

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Uterine Uptake Of Diazepam And Quantification By Gas Chromatography/Mass Spectrometry, Steven Scott Wolfe May 2003

Uterine Uptake Of Diazepam And Quantification By Gas Chromatography/Mass Spectrometry, Steven Scott Wolfe

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the difficulties in drug delivery is transporting the compound of interest to the target organ while minimizing exposure to the rest of the body. Intravenous administration is effective in the delivery of drugs and results in high bioavailability leading to very rapid systemic distribution. Oral dosing of drugs is the most popular route because of its ease of administration, but it is subject to first pass metabolism by the liver which can greatly reduce the bioavailability of the parent compound. Patients undergoing hysterectomy were recruited for a study in which they were anesthetized and 5 mg of diazepam …

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Feedback Control Of Wave Propagation Patterns In Excitable Media, Florin Chirila May 2003

Feedback Control Of Wave Propagation Patterns In Excitable Media, Florin Chirila

Graduate Theses, Dissertations, and Problem Reports (ETD)

Numerical and theoretical studies of the excitability boundaries for spiral waves in 2D and scroll waves in 3D are presented. The boundaries are defined by unstable wave segments, which are stabilized by using a negative feedback control algorithm. A kinematic description of the constant-size, constant-shape wave segments is presented for 2D waves. Intricate patterns of wave propagation are exhibited in a chemical reaction-diffusion system with spatiotemporal feedback. Wave behavior is controlled by feedback-regulated excitability gradients that guide propagation in specified directions. Waves reflecting or refracting are observed when interacting with a discontinuity in excitability. Wave trajectories in fixed excitability gradients …

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Durability Of Concrete Beams With Frp Wraps, Woraphot Prachasaree May 2003

Durability Of Concrete Beams With Frp Wraps, Woraphot Prachasaree

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research focuses on the durability of carbon FRP (CFRP) wraps bonded to concrete beams under accelerated and natural aging. Variation in mechanical properties of CFRP wrapped concrete beams due to aging through water immersion, salt and alkaline solution immersion at elevated and freeze-thaw temperature variation are studied. Different parameters evaluated during beam bending tests are: maximum load (moment), deflections, crack width, and deformability factor. Accelerated aging was carried out on 5"x8"x60" wrapped beams under: (1) water immersion at room, 110°F and 140°F temperatures; (2) alkaline and salt solution at room temperature; (3) alkaline and salt solution at freeze-thaw temperature. …

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Highways Of The Mind: The Haunting Of The Superhighway From The World's Fair To The World Wide Web., Helen J. Burgess Jan 2003

Highways Of The Mind: The Haunting Of The Superhighway From The World's Fair To The World Wide Web., Helen J. Burgess

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation investigates the way in which the rhetorical construction of the highway has been haunted, first by narratives of promise and progress and then of decay and death. Highways are figured as technological wonders marking the advent of a better future in the 1939 World's Fair and the advertising campaigns of the 1950s, and then as wired-up networks of death in science fictional accounts from the 60s to the 90s. At stake in this project is the very status of metaphor in the analysis of technology. The highway is a compelling 20th-century metaphor that reveals anxieties we have about …

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Sequence And Distribution Of The Neotyphodium Lolii Peptide Synthetase Gene Ipsa., Prapassorn Damrongkool Jan 2003

Sequence And Distribution Of The Neotyphodium Lolii Peptide Synthetase Gene Ipsa., Prapassorn Damrongkool

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neotyphodium lolii is a fungal endophyte of perennial ryegrass (Lolium perenne). Like related endophytes of other grasses, it increases the grass host's fitness. Endophyte-infected grasses have greater resistance to biotic and abiotic stress, and thus are highly competitive. However, the endophytes also produce toxins that cause toxicoses in grazing animals. N. lolii produces a large amount of lolitrems, which are thought to cause ryegrass staggers in mammals. The fungus also produces a smaller amount of a highly toxic ergopeptine ergovaline. In this dissertation, I have characterized, sequenced and surveyed the distribution of peptide synthetase gene IpsA that is required for …

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