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Graduate Theses, Dissertations, and Problem Reports (ETD)

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Microbial Quality And Pathogen Decontamination Strategies For Locally-Grown, Fresh Produce From West Virginia And Kentucky, Ka Wang Li Jan 2017

Microbial Quality And Pathogen Decontamination Strategies For Locally-Grown, Fresh Produce From West Virginia And Kentucky, Ka Wang Li

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study aimed to evaluate the microbiological quality/safety of fresh produce from farmers' markets (FM) and assess the post-harvest washing practice with antimicrobials to inactivate Salmonella and Listeria monocytogenes on fresh produce. In study I, 212 produce samples were tested for the presence of Salmonella and Listeria spp. using modified FDA-BAM methods. Aerobic plate counts (APCs), total coliforms (TCCs), and yeast/molds were analyzed on petri-films. Among the 212 samples, the APCs, TCCs, and yeast/molds were 3.72-5.63, 3.67-5.47, and 3.07-4.13 log CFU/g, respectively, with spinach containing the highest (P<0.05) populations. Among all tested samples, Salmonella enterica spp. enterica was detected on 18.6% of spinach, 10.9% of tomatoes, 18.5% of peppers, and 56.3% of cantaloupes, which is much higher than previous reported. Only 3.78% of the samples were confirmed for Listeria spp., and 50% of them were identified as L. monocytogenes, based on multiplex PCR results. Due to the high percentage of pathogens detected on the farmers' marker produce, an evaluation of post-harvest produce washing with various antimicrobials was conducted in study II. Specifically, spinach, tomatoes, green peppers and cucumbers were inoculated with S. Typhimurium and Tennessee or L. monocytogenes and washed in tap water, vinegar water (10%), lactic acid (5%), a lactic and citric acid blend (2.5%), and sodium hypochlorite (200 ppm) for 30 sec or unwashed. Vinegar water (10%) showed better (P<0.05) reduction of S. Typhimurium and Tennessee on tomatoes and cucumbers, and L. monocytogenes on tomatoes and peppers than tap water. The three antimicrobials reached an additional reduction level of 0.9 to 2.7 (S. Typhimurium and Tennessee) and 0.2 to 1.4 log CFU/g ( L. monocytogenes) compared to tap water. Lactic acid caused the greatest (P<0.05) reduction of S. Typhimurium and Tennessee on spinach and green peppers, and sodium hypochlorite showed the great (P<0.05) reduction of L. monocytogenes on cucumbers. The results supplied important information for FM vendors to develop post-harvest protocols to control foodborne pathogens.

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Implications Of Primary Cilia And Associated Lysophosphatidic Acid Signaling In Glioblastoma Biology And Therapy, Yuriy V. Loskutov Jan 2017

Implications Of Primary Cilia And Associated Lysophosphatidic Acid Signaling In Glioblastoma Biology And Therapy, Yuriy V. Loskutov

Graduate Theses, Dissertations, and Problem Reports (ETD)

The primary cilium is a ubiquitous organelle presented on most human cells. It serves as a crucial signaling hub for multiple pathways including growth factor and G-protein coupled receptors. Loss of primary cilia was observed in various cancers, however, the implications of this event are unclear. Several studies show that loss of cilia promotes cell proliferation, suggesting that alteration of ciliary-dependent signaling can drive the hyperproliferative phenotype of cancer cells, therefore re-establishing primary cilia or targeting altered signaling pathways could be a beneficial strategy as an anti-cancer therapy.;Glioblastoma (GBM) is one of the deadliest cancers with a median survival of …

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Academic Integrity Violation Detection For Wvu Cs101, Lakshman Chandrasekaran Jan 2017

Academic Integrity Violation Detection For Wvu Cs101, Lakshman Chandrasekaran

Graduate Theses, Dissertations, and Problem Reports (ETD)

We developed a software system to detect academic integrity violations within the course of Computer Science 101 taught at West Virginia University. In this course students are instructed on how to use the Microsoft Office suite of applications, including Access, Excel, PowerPoint, and Word for data analysis. Academic integrity is taken seriously at West Virginia University. The current system of checking for academic integrity violations has been effective, but there is room for improvement. The new software system for detecting academic integrity violations is user-friendly, computationally efficient, and time-saving for instructors of Computer Science 101. The underlying idea is to …

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A System To Secure Websites And Educate Students About Cyber Security Through Crowdsourcing, Chitrangi Sameer Doshi Jan 2017

A System To Secure Websites And Educate Students About Cyber Security Through Crowdsourcing, Chitrangi Sameer Doshi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Startups are innovative companies who have ideas for the betterment of the society. But, due to limited resources, and highly expensive testing procedures, they invest less time and money in securing their website and web applications. Furthermore, cyber security education lacks integrating practical knowledge with educational theoretical materials. Recognizing, the need to educate both startups and students about cyber security, this report presents Secure Startup - a novel system, that aims to provide startups with a platform to protect their website in a costeffective manner, while educating students about the real-world cyber skills. This system finds potential security problems in …

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Analyzing Discovery Latency In Mobile Networks, Saud Alramzi Jan 2017

Analyzing Discovery Latency In Mobile Networks, Saud Alramzi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Duty cycle is important in wireless sensor and mobile ad-hoc networks (MANETs) to extend their lifetime. Duty cycling in wireless networks lets the nodes wake up with infrequent fixed periods, based on pre-determined parameters. On the other hand, neighbor discovery is the process by which nodes learn about the neighbors. Nodes can use radio communications to discover other neighbors. Timely, neighbor discovery is crucial for routing. But, neighbor discovery becomes more challenging in energy-constrained, mobile environment with duty cycled nodes where a node may not know whether any neighbors are present, and what duty cycle those neighbors might operate at. …

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Scholars And Knowledge Sharing On Twitter, Pravija Krishna Jan 2017

Scholars And Knowledge Sharing On Twitter, Pravija Krishna

Graduate Theses, Dissertations, and Problem Reports (ETD)

There has always been an invisible gap between members of the scientific community - scholars (professors & researchers), science fans (subject matter experts) and novices (general public who are enthusiastic about science or any other field). This report aims at bridging that gap and exploring to what extent the scientic community is willing and able to share their knowledge with the general public. Several studies were conducted both on Twitter and manually. The results of these studies were vital in proposing a system that could help increase the level of sharing of knowledge by scholars and science fans in addition …

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Exposure Monitoring And Controlling Hazards In Additive Manufacturing Processes, Tyler John Kusich Jan 2017

Exposure Monitoring And Controlling Hazards In Additive Manufacturing Processes, Tyler John Kusich

Graduate Theses, Dissertations, and Problem Reports (ETD)

Additive manufacturing (AM) is a relatively new field that promises advancement in various disciplines such as medical, aerospace, and consumer products. One of the recent developments in additive manufacturing is with the use of metal powders, such as aluminum, nickel, and chromium. AM processes are projected to become more common as the technology advances and the applications spread into a variety of different industries. There are several health and safety risks that have been identified with the use of these powders, including combustible dust and health exposure issues. This study was aimed at looking at some of the issues with …

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Genetic Analysis Of The Biosynthesis Of Pharmaceutically Important Dihydroergot Alkaloids By Heterologous Expression Of Claviceps Gigantea Genes In The Fungus Neosartorya Fumigata, Paige E. Bragg Jan 2017

Genetic Analysis Of The Biosynthesis Of Pharmaceutically Important Dihydroergot Alkaloids By Heterologous Expression Of Claviceps Gigantea Genes In The Fungus Neosartorya Fumigata, Paige E. Bragg

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ergot alkaloids are a family of secondary metabolites produced by several species of fungi. The structural similarities of ergot alkaloids to neurotransmitters give them the ability to help treat several neurological and cognitive diseases, such as dementia, Alzheimer's and Parkinson's disease. These pharmaceuticals are currently being synthesized from more complex ergot alkaloids, however they would be more efficiently synthesized from dihydroergot alkaloids. Understanding the genes involved in the synthesis of dihydroergot alkaloids, such as dihydrolysergol and dihydrolysergic acid, and elucidating their pathways will be beneficial. The Mexican maize ergot pathogen Claviceps gigantea has been reported to produce dihydrolysergol, which is …

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Visualizing The Impacts Of Extreme Weather Events Using 3d Visualization To Aid Pre-Event Risk Communication, Thomas L. Brown Jan 2017

Visualizing The Impacts Of Extreme Weather Events Using 3d Visualization To Aid Pre-Event Risk Communication, Thomas L. Brown

Graduate Theses, Dissertations, and Problem Reports (ETD)

Weather is everywhere. Rapidly expanding capabilities in information technology present an opportunity to develop better warning products for extreme weather events. In the wake of recent extreme events from Superstorm Sandy to Hurricane Matthew, the National Oceanic and Atmospheric Administration and the National Weather Service have repeated the call for improving techniques for disseminating critical information to the general public during potential weather disasters. This research uses 3D GIS and geovisualization to improve the communication of expert risk information to the general public.

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Reimagining The Ssmint Software Package, Kelly Cecil Jan 2017

Reimagining The Ssmint Software Package, Kelly Cecil

Graduate Theses, Dissertations, and Problem Reports (ETD)

We examine two proposed indexing algorithms taking advantage of the new SSMinT libraries. The two algorithms primarily differ in their selection of documents for learning. The batch indexing method selects some random number of documents for learning. The iterative indexing method uses a single randomly selected document to discover semantic signatures, which are then used to find additional related documents. The batch indexing method discovers one to three semantic signatures per document, resulting in poor clustering performance as evaluated by human cross-validation of clusters using the Adjusted Rand Index. The iterative indexing method discovers more semantic signatures per document, resulting …

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Removal Of Zinc Ions From Model Wastewater By Electrocoagulation, Xiujuan Chen Jan 2017

Removal Of Zinc Ions From Model Wastewater By Electrocoagulation, Xiujuan Chen

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study has investigated the removal of zinc ions from the synthetic wastewater models by electrocoagulation (EC) with aluminum for both cathode and anode. The results showed that EC process had a great removal when it comes to zinc contaminated water. The effects of parameters on the EC performance have been systematically investigated, such as solution conductivity, electrode spacing, initial pH, current density and initial zinc concentration. Since the wastewater in real situations usually contains several types of metals, a series of mixed cases were also studied in this work.;The results indicated that current density is critical to EC performance, …

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Intersectionality Effects On Veterans Health Outcomes, James M. Conley Jan 2017

Intersectionality Effects On Veterans Health Outcomes, James M. Conley

Graduate Theses, Dissertations, and Problem Reports (ETD)

This paper examines the combined influence of racial minority and sexual minority statuses on the health outcomes of US military veterans. I describe the effect of multiple minority statuses on reported health indicators from a nationally representative survey instrument. The data used for this study comes from 20 US states which elected to include an optional, but standardized, module on sexual orientation as part of the 2014 Behavioral Risk Factor Surveillance System (BRFSS) and 21 US states which elected to use that same module in the 2015 BRFSS. The sample of analysis contains 35,163 respondents who identified as US military …

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Adaptation Of Simulated Annealing For Rate Of Penetration Optimization In Automated Drilling, Zachary Cox Jan 2017

Adaptation Of Simulated Annealing For Rate Of Penetration Optimization In Automated Drilling, Zachary Cox

Graduate Theses, Dissertations, and Problem Reports (ETD)

Drilling automation has focused on developing predictive controls based on existing formation and well sites for which abundant data is available. These methods are not suitable in new locations where there is little information and where drilling data has not been recorded. This study focuses on a proof-of-concept to allow drilling in locations with little or no data available by determining drilling parameters via an artificial intelligence algorithm. The methods used were tested for use in the second annual Drillbotics competition sponsored by the Drilling Systems Automation Technical Section (DSATS) of the Society of Petroleum Engineers (SPE).;This study addresses the …

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A Multidimensional Approach To Understanding Gender And Health Among Middle-Aged And Older Adults, Rebecca K. Delaney Jan 2017

A Multidimensional Approach To Understanding Gender And Health Among Middle-Aged And Older Adults, Rebecca K. Delaney

Graduate Theses, Dissertations, and Problem Reports (ETD)

"Women get sicker, men die quicker," is a statement used to describe how women suffer from more chronic health conditions, greater physical limitations, and report poorer health compared to men (Crimmins, Kim, & Sole -Auro, 2011; Lochner & Cox, 2010), whereas men have a shorter life expectancy compared to women (CDC, 2013). Although biological sex differences offer some explanation for why men and women differ in health and mortality, there is much left unexplained (Miller, 2014). Gender, a psychosocial construct that reflects attitudes, feelings, and behaviors prescribed by cultural expectations for men and women (Unger, 1979) has been highlighted as …

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A Qualitative Study Of Family Forest Owners' Experiences With Timber Transactions, Adam Maltempie Jan 2017

A Qualitative Study Of Family Forest Owners' Experiences With Timber Transactions, Adam Maltempie

Graduate Theses, Dissertations, and Problem Reports (ETD)

The majority of forestland in America is privately owned. Family forest owners own 62% of all private forestland in America. In West Virginia family forest owners own 6.5 million acres (53%) of all forestland in the state. Timber harvesting from these family forests is crucial to the states and nations timber industry. We examined family forest owners' experiences during the complex timber transaction process. This process covers the time from when the landowner decides to sell timber until all harvest, legal, and financial aspects are completed. We conducted a focus group with nine participants representing eight different family owned forests …

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On Designing Deep Learning Approaches For Classification Of Football Jersey Images In The Wild, Rohitha Reddy Matta Jan 2017

On Designing Deep Learning Approaches For Classification Of Football Jersey Images In The Wild, Rohitha Reddy Matta

Graduate Theses, Dissertations, and Problem Reports (ETD)

Internet shopping has spread wide and into social networking. Someone may want to buy a shirt, accessories, etc., in a random picture or a streaming video. In this thesis, the problem of automatic classification was taken upon, constraining the target to jerseys in the wild, assuming the object is detected.;A dataset of 7,840 jersey images, namely the JerseyXIV is created, containing images of 14 categories of various football jersey types (Home and Alternate) belonging to 10 teams of 2015 Big 12 Conference football season. The quality of images varies in terms of pose, standoff distance, level of occlusion and illumination. …

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The Assessment Of Fingerprint Quality For A More Effective Match Score In Minutiae-Based Matching Performers, Alyshia Meyers Jan 2017

The Assessment Of Fingerprint Quality For A More Effective Match Score In Minutiae-Based Matching Performers, Alyshia Meyers

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the most common types of evidence recovered from a crime scene are latent fingerprints, however these impressions are often of low quality. The quality of a latent fingerprint is described as the degree to which the ridge details can be observed. If the quality of the latent fingerprint is very clear, a minutiae-based matching algorithm with automatic extraction may detect and utilize the minutiae that are truly present in the fingerprint. However, if the impression is of poor quality, the minutiae-based matching algorithm's automatic extraction may detect fewer features and could completely miss features resulting in the return …

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On Some Parabolic Type Problems From Thin Film Theory And Chemical Reaction-Diffusion Networks, Fatma Naser Ali Mohamed Jan 2017

On Some Parabolic Type Problems From Thin Film Theory And Chemical Reaction-Diffusion Networks, Fatma Naser Ali Mohamed

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation considers some parabolic type problems from thin film theory and chemical reaction-diffusion networks. The dissertation consists of two parts:;In the first part, we study the evolution of a thin film of fluid modeled by the lubrication approximation for thin viscous films. We prove an existence of (dissipative) strong solutions for the Cauchy problem when the sub-diffusive exponent ranges between 3/8 and 2; then we show that these solutions tend to zero at rates matching the decay of the source-type self-similar solutions with zero contact angle. We introduce the weaker concept of dissipative mild solutions and we show that, …

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Novel Treatment Strategies For Brain Metastases Of Breast Cancer, Afroz Shareef Mohammad Jan 2017

Novel Treatment Strategies For Brain Metastases Of Breast Cancer, Afroz Shareef Mohammad

Graduate Theses, Dissertations, and Problem Reports (ETD)

About 20-40% of advanced breast cancer patients will develop symptomatic brain metastases. Once the patients diagnosed with metastatic brain tumors, there is 80% mortality rate within one year. The presence of blood-brain barrier makes it difficult for drugs to reach the site of action in brain-related ailments. To overcome we came up with two strategies: First, we encapsulated the chemotherapy in a liposome and thereby significantly improving the plasma pharmacokinetics of chemotherapy. We also observed that tumor drug exposure significantly improved by liposomal formulation. This improvement in plasma drug pharmacokinetics and tumor drug accumulation after administration of the liposomal formulation …

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Reactions Of Metal Carbides To Produce Carbon, Jeremy Hardinger Jan 2017

Reactions Of Metal Carbides To Produce Carbon, Jeremy Hardinger

Graduate Theses, Dissertations, and Problem Reports (ETD)

Calcium carbide was historically used to reduce potassium metal from potassium fluoride as described in a 1922 patent. This was prior to the discovery of electrolytic synthesis, which replaced the carbide process in less than five years. A byproduct of this process was elemental carbon. This carbon was unanalyzed at the time. The object of this research was to analyze carbon produced in reactions similar to this and to determine if this reaction could be carried out under milder conditions. It was found that the reaction is part of a family of reactions, and would proceed with a number of …

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Leakage Evaluation Of Three Endodontic Sealers Used In A Single-Cone Technique: A Study Using Bioluminescent Bacteria, Sean M. Horan Jan 2017

Leakage Evaluation Of Three Endodontic Sealers Used In A Single-Cone Technique: A Study Using Bioluminescent Bacteria, Sean M. Horan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction.;After proper chemomechanical disinfection and obturation of a root canal system, the next important goal in endodontic therapy is obtaining an adequate coronal seal. If the coronal seal becomes compromised, it is difficult to decide whether the root canal system should be re-treated. This decision should be made based on the ability of the root canal filling to resist bacterial contamination and on the length of time the seal has been compromised.;The root canal system should be filled in three dimensions, typically with a combination of gutta percha and sealer. One obturation method that has seen a revival in recent …

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Diversity And Function Of Fungi Associated With The Fungivorous Millipede, Brachycybe Lecontii, Angie M. Macias Jan 2017

Diversity And Function Of Fungi Associated With The Fungivorous Millipede, Brachycybe Lecontii, Angie M. Macias

Graduate Theses, Dissertations, and Problem Reports (ETD)

Brachycybe (Wood) is a genus of fungivorous millipedes. To date, the fungal associates of these millipedes have never been characterized. In an attempt to resolve these relationships, culture-based approaches combined with DNA barcode sequencing were used. Sampling of 313 individuals collected from three of four B. lecontii clades and 20 sites across seven states uncovered at least 183 genera in 40 orders from four fungal phyla. At least seven putative new species were recovered in this study, despite the use of more classical culture-based approaches. Three of these fungi were phylogenetically resolved using ITS + LSU and include two new …

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Hydraulic And Thermal Response To Intermittent Pumping In Unconfined Alluvial Aquifers Along A Regulated Stream, Madan Maharjan Jan 2017

Hydraulic And Thermal Response To Intermittent Pumping In Unconfined Alluvial Aquifers Along A Regulated Stream, Madan Maharjan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Groundwater response to stream stage fluctuations was studied using a year-long time series of stream stage and well heads in Glen Dale and New Martinsville, WV. Stream stage fluctuations exerted primary control over groundwater levels, especially during high flows. The location and operation of river pools created by dams alter groundwater flow paths and velocities. Aquifers are more prone to surface water infiltration in the upper reaches of pools than in lower reaches. Aquifer diffusivity is heterogeneous within and between the two sites.;Temperature fluctuations were observed for 2.5 years in 14 wells in three alluvial aquifers. Temperature signals have 2 …

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A Learning History Study Of Sustainable Management In Producing An Inaugural Solar Decathlon Entry, Dana Shearer Jan 2016

A Learning History Study Of Sustainable Management In Producing An Inaugural Solar Decathlon Entry, Dana Shearer

Graduate Theses, Dissertations, and Problem Reports (ETD)

A Learning History approach was used to study the processes and outcomes of West Virginia University's inaugural (2013) Solar Decathlon team as it planned and executed its entry to the competition. In this competition, the product must be a house that meets several standards for sustainable management of material and energy resources. This study conceives of the human resources required to produce an entry as a complementary valuable resource that also can be managed more or less sustainably. Applying principles of sustainable management to evaluate the team's process and the transmission of knowledge to future teams, analysis of the experiences …

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Oversized Load, Kaitlyn Noel Hunter Jan 2016

Oversized Load, Kaitlyn Noel Hunter

Graduate Theses, Dissertations, and Problem Reports (ETD)

This paper explores the research, artwork and processes that culminated in the "Oversized Load" Master Of Fine Arts thesis exhibition. I am examining the similarities between fear and perception of fictionalized monsters and how we label each other as humans. The fundamental question being, at what point does someone become the "other"? I look at both otherness and the grotesque in the context of body image. Both ostracization and cultural stigma are initiated by social shame. I see monsters as the physical manifestation of that shame. These feelings are closely tied to socially constructed gender norms and standards of beauty. …

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Paradoxical Roles Of Nanoparticles In Cancer Therapeutics And Carcinogenesis, Emily Despeaux Jan 2016

Paradoxical Roles Of Nanoparticles In Cancer Therapeutics And Carcinogenesis, Emily Despeaux

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nanoparticles (NPs) are becoming increasingly common in consumer goods and are under investigation for a variety of industrial and biomedical applications. However, challenges in determining NP toxicity may prevent them from reaching their full potential. NPs cannot be treated as single class for toxicity evaluations. Even among particles made from the same material, particle-specific physical properties, including size, shape, surface charge, agglomeration state, and surface modifications have a strong effect on the toxicity. Even so, the obstacles to conclusively and reproducibly evaluating toxicity span all NP classes. NP literature is riddled with confusing and often contradictory reports regarding the biocompatibility …

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Synchrotron Investigations On La0.7Sr0.3Mno 3/Pbzr0.2Ti0.8O3 Heterostructures., Jinling Zhou Jan 2016

Synchrotron Investigations On La0.7Sr0.3Mno 3/Pbzr0.2Ti0.8O3 Heterostructures., Jinling Zhou

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation is devoted to understanding the La0.7Sr0.3MnO3 (LSMO)/ PbZr0.2Ti0.8O3 (PZT) magnetoelectric interface through synchrotron x-ray absorption and other techniques. The word magnetoelectric (ME) describes the coupling effects in certain materials that exhibit a change of the magnetic (electric) order with the change of the electric (magnetic) field. Materials that are ME could potentially advance current technology. Faster, more sensitive, and more energy efficient devices can be built with ME materials as compared to the present systems. Practical ME materials are essential for the realization of this advancement. Single phase ME materials are rare and the known few do not …

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Consumers' Uses Of Nutrient Content Claims And Their Relationship With Health Orientation And Online Media Exposure And Attention, Kelly A. Williams Jan 2016

Consumers' Uses Of Nutrient Content Claims And Their Relationship With Health Orientation And Online Media Exposure And Attention, Kelly A. Williams

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this research is to explore consumers' general uses of nutrient content claims on food packaging. In addition, the research looks at an individual's self-reported health orientation, as well as their personal online media usage. This study used quantitative research to explore these factors. An online survey of the individuals who make personal health and food choices was conducted to better understand their reported uses of nutritional claims, as well as their lifestyle habits. Findings suggest that individuals do use nutrient content claims while looking at food packaging, and that this significantly relates to their health orientation and …

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Integrating Stimulation Practices With Geo-Mechanical Properties In Liquid-Rich Plays Of Eagle Ford Shale, Ahmed Yusuf Jan 2016

Integrating Stimulation Practices With Geo-Mechanical Properties In Liquid-Rich Plays Of Eagle Ford Shale, Ahmed Yusuf

Graduate Theses, Dissertations, and Problem Reports (ETD)

Many of the techniques for hydraulically fracturing design were attempted in the liquid-rich Eagle Ford developments. This study shows why different results were observed due to the variation of geomechanical stresses of the rock across a play and related reservoir properties. An optimum treatment for a liquids-rich objective is much different than that for a gas shale due primarily to the multiphase flow and higher viscosities encountered.;This study presents a new treatment workflow for liquids-rich window of Eagle Ford Shale. Review and integration of data from multiple sets across the play are used as input to a 3D hydraulic fracture …

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Bone Marrow Microenvironment Regulation Of Bcl6 In Acute Lymphoblastic Leukemia, William Lee Slone Jan 2016

Bone Marrow Microenvironment Regulation Of Bcl6 In Acute Lymphoblastic Leukemia, William Lee Slone

Graduate Theses, Dissertations, and Problem Reports (ETD)

Acute lymphoblastic leukemia (ALL) is a hematological malignancy with approximately 6000 newly diagnosed cases every year. Although ALL is the most common malignancy in children, it can occur in patients of all ages. Great strides have been made in the treatment of ALL and remission rates are at all-time highs. However, relapse rates have remained relatively consistent, and relapse continues to be correlated with a poor prognosis in patients with ALL. As the site of origin and progression of ALL, the bone marrow microenvironment (BMM) is important in regulating tumor cell quiescence and proliferation. Of clinical relevance is the frequency …

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