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Repeatability, Recency, And Response Recovery: An Experimental Analysis Of Resurgence., Gregory Alan Lieving
Repeatability, Recency, And Response Recovery: An Experimental Analysis Of Resurgence., Gregory Alan Lieving
Graduate Theses, Dissertations, and Problem Reports (ETD)
Four experiments were conducted to assess some of the variables controlling resurgence. The basic procedure involved three conditions: (1) reinforcement of key pecking, (2) reinforcement of treadle pressing, (3) the resurgence condition. In Experiment 1, the resurgence condition was conventional extinction. The extent to which resurgence is replicable was assessed by repeating the three conditions within subjects. Resurgence was demonstrated to be a repeatable effect. In Experiment 2, the effects of reinforcement recency were examined by manipulating the number of sessions (5 versus 30) of Condition 2, and the resurgence condition consisted of conventional extinction. Resurgence was not a function …
The Influence Of Context, Amount Of Experience, And Rater Characteristics On Temperament Ratings Of Toddlers., Melinda Maher
The Influence Of Context, Amount Of Experience, And Rater Characteristics On Temperament Ratings Of Toddlers., Melinda Maher
Graduate Theses, Dissertations, and Problem Reports (ETD)
Although temperament is generally defined as an individual’s stable behavioral style, comparisons of temperament ratings derived from different sources typically yield only low to moderate correlations. The present study investigated three potential influences on toddler temperament ratings: the context of the observation, the raters’ amount of experience with the child, and rater characteristics. Thirty toddlers (14 to 36 months old) were included in the study. For each toddler, temperament ratings were provided by his/her mother, father, two day care teachers, a home observer, and a day care observer. Toddler temperament was assessed using the TTS, EAS, and a global temperament …
A Risk Assessment Of Nursing Personnel Injuries Occurring While Lifting, Transferring Or Repositioning Nursing Home Residents., James T. Culligan
A Risk Assessment Of Nursing Personnel Injuries Occurring While Lifting, Transferring Or Repositioning Nursing Home Residents., James T. Culligan
Graduate Theses, Dissertations, and Problem Reports (ETD)
The primary objective of this research thesis was to identify the root causal factors associated with lost time injuries occurring among nursing personnel in long term care facilities. The critical elements assessed and evaluated include: length of service; time of day injury occurred; task being completed when injury occurred; similar incidents in the past (accident repeaters); type of shift on which injury occurred; number of hours worked the day injury occurred; impact of company policy; availability of mechanical lifts; training on how and when to use mechanical lifts; exercise; stretching; training on safe lifting techniques or good body mechanics; gait …
The Decline In Rural Hospitals: The Effect Of Investor-Owned Hospitals., Angela Marie Foley
The Decline In Rural Hospitals: The Effect Of Investor-Owned Hospitals., Angela Marie Foley
Graduate Theses, Dissertations, and Problem Reports (ETD)
Rural health care deserves special attention because rural areas have high poverty rates, a high proportion of elderly residents, and high-risk job conditions. However, the number of rural hospitals, often a rural areasí main source of health care, is decreasing. Literature has shown that one of the main factors in hospital closure is ownership, specifically for-profit. This study examines trends in rural hospitals and other factors, including for-profit ownership, that may affect the declining number of rural hospitals. Data are drawn from annual hospital data from 1974 to 1995. A moving time series analysis is used to present the trends …
The Effectiveness Of Nutrition Education On Nutrition Knowledge Of Female College Athletes., Joanne Chieppa
The Effectiveness Of Nutrition Education On Nutrition Knowledge Of Female College Athletes., Joanne Chieppa
Graduate Theses, Dissertations, and Problem Reports (ETD)
Subjects were 43 female athletes who participated on three different teams. Interventions were one-page two-sided nutrition newsletters. A consent form, information sheet and 20- question pre-test were given the first day of practice, after which subjects received newsletters every month for three months. Athletes were given a post-test three weeks after they had received the third newsletter. Pre and post-test scores were compared using t-tests. Results showed that nutrition education in the form of newsletters had a significant effect on knowledge. No significant differences were found among teams, by competition status or nutrition course status, i.e. whether individuals had taken, …
The Influence Of Participation In Secondary Agriculture Activities On Post-Secondary Pursuits Of Agriculture Students In West Virginia., Harold Daniel Junkins
The Influence Of Participation In Secondary Agriculture Activities On Post-Secondary Pursuits Of Agriculture Students In West Virginia., Harold Daniel Junkins
Graduate Theses, Dissertations, and Problem Reports (ETD)
The purpose of the study was to provide information on the influence of agriculture activity participation on the pursuits of secondary agriculture students in West Virginia. Data were collected via questionnaires. The questionnaires consisted of three parts: (a) demographic data; (b) post-secondary status; and (c) grade performance and agriculture activities participation. Participation levels were determined by combining scores received in SAEP, technical agriculture competitions and leadership activities. Post-secondary status was grouped by education in the field of agriculture and non-agriculture, employment in agriculture and non-agriculture, unemployment, and military service. Students who scored higher in participation level were more apt to …
Production Of Urban Space In Kenya: Central-Local Government Power Relations In Mediating Space In Athi River Town., Francis Tama Koti
Production Of Urban Space In Kenya: Central-Local Government Power Relations In Mediating Space In Athi River Town., Francis Tama Koti
Graduate Theses, Dissertations, and Problem Reports (ETD)
Centrally controlled political and economic systems are popular among Third World countries. They however, become problematic particularly in rapidly growing urban areas where different forces compete for scarce resources, hence calling for an understanding of the nature of the relationships between the different forces that produce the urban environment. In Kenya, the basic assumption is that urban space is mediated by the local state. The author uses Athi River town, as a case study, through which survey questionnaires and informal interviews are conducted with key personnel of Mavoko Municipal Council on one hand, and central government ministries operating within the …
Background Concentrations Of Trace Elements In Three West Virginia Soils: Mlra-126., April Dawn Slagle
Background Concentrations Of Trace Elements In Three West Virginia Soils: Mlra-126., April Dawn Slagle
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background quantities of trace elements were surveyed in Major Land Resource Area 126, the Central Appalachian Plateau in northwestern West Virginia. Three pedons each of Upshur, Vandalia, (both Typic Hapludalfs) and Gilpin (Typic Hapludult) soils were described and sampled in Doddridge, Mason and Clay counties. Twelve trace elements were extracted from soil samples by the EPA 3051 and hydrofluoric acid methods. The data from both procedures showed that except for Ca and Mg, the HF method extracted greater quantities of trace elements than EPA Method 3051. Significant differences were found for all trace elements except Cd, Cr, and Pb. Calcium, …
Knowledge And Utilization Of Ultrasonic/Sonic Scaling Instruments: A Survey Of West Virginia Dental Hygienists., Janet Lucille Bee
Knowledge And Utilization Of Ultrasonic/Sonic Scaling Instruments: A Survey Of West Virginia Dental Hygienists., Janet Lucille Bee
Graduate Theses, Dissertations, and Problem Reports (ETD)
Recent progress in understanding periodontal disease, combined with advances in the design and efficiency of powered scaling instruments suggest the need to reexamine the use of powered scaling instruments. A literature review reveals a lack of information addressing the extent of utilization of these instruments by dental hygienists. However, the literature is replete with information recommending the use of these devices in the treatment of periodontal disease. Information describing the knowledge level dental hygienists posses about ultrasonic/sonics and their current philosophy for using these instruments is needed. The purpose of this study was to determine how dental hygienists use powered …
Continuing Education In Dental Hygiene: Assessment Of Content And Competencies., Jill L. Self
Continuing Education In Dental Hygiene: Assessment Of Content And Competencies., Jill L. Self
Graduate Theses, Dissertations, and Problem Reports (ETD)
Although forty-six of the fifty states (92%) currently require continuing dental education (CDE) course attendance to maintain licensure in dental hygiene, a wide range of continuing education requirements exists. The purpose of this study was to survey registered dental hygienists regarding their perceptions and experiences of continuing education and the existence and extent of competency assessments conducted at continuing education courses attended. A 28 question survey was mailed to licensed dental hygienists residing in West Virginia (n=780) and Colorado (n=1130). Although continuing education continues to be a viable method of gaining knowledge and enhancing skills, CDE course assessment of competencies …
Dimensional Changes Of Polysulfide Impression Materials Over Time., Saeid Zeiaei-Nafchi
Dimensional Changes Of Polysulfide Impression Materials Over Time., Saeid Zeiaei-Nafchi
Graduate Theses, Dissertations, and Problem Reports (ETD)
The purpose of this study was to investigate the effect of time on dimensional changes of polysulfide impression materials over time. A stainless steel die fabricated according to the ADA, Standards Specification No.19 was used. Measurements were carried out at 15 minutes intervals up to 3 hours and at 6, 12, and 24 hours. Results, the mean, and the percentage dimensional changes were reported. All collected data was based on a repeated measure design. Split plot analysis of variance at P< 0.05 was used to calculate any statistically significant dimensional changes over time among the three impression materials. All three impression materials tested could produce replicas with clinically acceptable dimensional changes up to 24 hours after making the impression. However, after 3 hours, there were significantly greater dimensional changes approaching our standard of 40 µm acceptability. It is therefore recommended that polysulfide impression materials be poured within 3 hours of making the impression.
A Model For A Fles Program In Morgantown, West Virginia., Isabel Cristina Cadavid-Munera
A Model For A Fles Program In Morgantown, West Virginia., Isabel Cristina Cadavid-Munera
Graduate Theses, Dissertations, and Problem Reports (ETD)
There is an increasing interest in the development and implementation of foreign language programs in elementary school throughout the U.S. However, as some experts on the field of teaching foreign languages to children have pointed out, very often those programs are implemented without prior planning or thorough investigation. The present study was conducted in five schools in Morgantown, West Virginia, in order to determine the major strengths and weaknesses of the foreign language after school classes currently carried out at those schools. Questionnaires (to parents, classroom teachers, Spanish instructors, and site coordinators), class observations and interviews were the ethnographic techniques …
Grassroots Organizations And Gis: Assessing The Role Of Geographical Information And Gis In Grassroots Watershed Organizations In West Virginia., Jessica L. Spicer
Grassroots Organizations And Gis: Assessing The Role Of Geographical Information And Gis In Grassroots Watershed Organizations In West Virginia., Jessica L. Spicer
Graduate Theses, Dissertations, and Problem Reports (ETD)
A growing number of organizations, especially “grassroots” organizations are seeking to make use of Geographic Information Systems (GIS) and geographical information. In most cases, however, the use and potential use or benefits of GIS for “grassroots” organizations have been far from realized. The overall goal of this project is to explore grassroots awareness of, understanding of, use of, and proposed use of GIS for assessing watershed issues and to do this in the context of the issue raised by the GIS and society debate. The use of four West Virginia watershed case studies served to identify some of the major …
The Effects Of Smoking On Blood Cells, And The Association Between Smoking And Nutrient Intake Among Pregnant Women Residing In Northern West Virginia., Rebecca King
Graduate Theses, Dissertations, and Problem Reports (ETD)
Cigarette smoking is a risk factor in respiratory disease, cancer and cardiovascular diseases and other health problems. The purpose of the study was to determine the effects of smoking on white blood cells and to assess the relation between smoking, red blood cells, nutrient intake, and newborn weight among pregnant WIC participants residing in Northern West Virginia. The study consisted of 110 pregnant women. Data for this study were obtained by in-person interviews at the clinical site or at the participants' home. The findings of the study indicated that the smokers, white blood cells and lymphocytes were positively associated with …
Dads Do Matter: Relationship Between Father-Child Interaction And Child Social Anxiety., Laurie Ann Greco
Dads Do Matter: Relationship Between Father-Child Interaction And Child Social Anxiety., Laurie Ann Greco
Graduate Theses, Dissertations, and Problem Reports (ETD)
To date, research investigating parental influences contributing to the development of social anxiety has focused on maternal characteristics and the mother-child relationship. The role of fathers in the development of childhood-onset psychopathology has received relative inattention (e.g., Phares, 1996) and remains virtually unexplored within the realm of social anxiety. This study focused on identifying both maternal and paternal factors that may impact the development and maintenance of social anxiety experienced by school-aged children. Forty-eight (22 high socially anxious, 26 low socially anxious) children and their fathers completed self-report questionnaires, and father-child interactions during a ten-minute challenging task were conducted. Consistent …
Evaluation Of Vibration Response Of Ceramic Candle Filters Using An Accelerometer And A Laser Vibrometer., Ye Hone Lin
Evaluation Of Vibration Response Of Ceramic Candle Filters Using An Accelerometer And A Laser Vibrometer., Ye Hone Lin
Graduate Theses, Dissertations, and Problem Reports (ETD)
Ceramic candle filters are key components for a successful coal-based power-generation system. The ceramic candle filter is a hollow cylindrical structure made of a porous material. One end is closed with a cap and the other end is open. Ceramic candles are one of the few clean-up technologies that can protect the heat exchanger and consistently meet the gas turbine manufacturer’s inlet particulate requirement to prevent erosion. A total of three ceramic candle filters were tested nondestructively to investigate the boundary conditions of the filters using a laser vibrometer and an accelerometer. The study includes evaluation of vibration data from …
Material Evaluation Of Liquid Metal Corrosion In Zinc-Aluminum Hot Dip Coating Baths., Matthew Ly Burris
Material Evaluation Of Liquid Metal Corrosion In Zinc-Aluminum Hot Dip Coating Baths., Matthew Ly Burris
Graduate Theses, Dissertations, and Problem Reports (ETD)
The corrosion of bath hardware used in continuous galvanization lines is a great challenge within the hot-dip coating industry today. The objective of this research was to examine the potential of using intermetallic Fe3Al alloys developed at Oak Ridge National Laboratory in the bath hardware application of the continuous hot-dipping process. In order to examine the effectiveness of Fe3Al in this harsh, molten metal environment, two sets of liquid metal corrosion tests were carried out. The purpose of the first set of experiments was to examine the effect of test duration on the corrosion of the different alloys. The testing …
An Economic Analysis Of The Relationship Of Poverty And Income Inequality In Rural West Virginia., Semoa Costa Batista De Sousa
An Economic Analysis Of The Relationship Of Poverty And Income Inequality In Rural West Virginia., Semoa Costa Batista De Sousa
Graduate Theses, Dissertations, and Problem Reports (ETD)
There have been numerous research studies on poverty, income inequality, economic growth, and the relationship between these variables at national and regional levels. This thesis focuses on poverty and income inequality, in 38 rural counties of West Virginia. The study examines the possibility of simultaneity between poverty and income inequality (Gini index) using a two-stage least square regression with cross-sectional data for 1980 and 1990. Furthermore, ordinary least square regressions are used to investigate the main determinants of poverty and income inequality. The results confirm the possibility of simultaneity between poverty and income inequality. The proportions of the population in …
The Role Of Lois Marie Gibbs In The Love Canal Crisis And Its Effect On Federal "Superfund" Legislation, 1973-1981., Daniel Victor Kahler
The Role Of Lois Marie Gibbs In The Love Canal Crisis And Its Effect On Federal "Superfund" Legislation, 1973-1981., Daniel Victor Kahler
Graduate Theses, Dissertations, and Problem Reports (ETD)
In the spring of 1978, a young homemaker named Lois Marie Gibbs discovered that her child was attending an elementary school built on top of a 20,000 ton, toxic chemical dump in Niagara Falls, New York. Out of desperation, she organized her neighbors into the Love Canal Homeowners Association and struggled more than two years for relocation. Opposing the group’s efforts were the chemical manufacturer, Hooker Chemical Corporation, and local, state, and federal government officials who insisted that the leaking toxic chemicals, including dioxin the most toxic chemical known to man, was not the cause of high rates of birth …
Use Of Track-Etched Polycarbonate Filters In Series To Mimic The Total Human Lung Deposition In The Ultrafine And Fine Particle Range From 0.03 To 0.40 Microns., Jennifer Lynn Hornsby-Myers
Use Of Track-Etched Polycarbonate Filters In Series To Mimic The Total Human Lung Deposition In The Ultrafine And Fine Particle Range From 0.03 To 0.40 Microns., Jennifer Lynn Hornsby-Myers
Graduate Theses, Dissertations, and Problem Reports (ETD)
Three 3.0m polycarbonate track-etched filters were used in series in a 37 mm cassette and tested at 2.2 L/min using an automated filter tester to determine the filter assembly’s deposition curve as a function of particle size from 0.03 to 0.4 m. The filter assembly’s efficiency curve was compared to Stahlhofen’s resting with nose breathing and working with mouth breathing human total lung deposition curves used by the ICRP. Bias maps show that the shape of the filter assembly’s deposition curve matches the two lung deposition curves in the ultrafine range under these specific test conditions. The efficiency curve of …
The Effect Of Providing Bedding Encasings On Adherence To Dust Mite Control Procedures In Pediatric Asthma Patients., Karen Elizabeth Joseph
The Effect Of Providing Bedding Encasings On Adherence To Dust Mite Control Procedures In Pediatric Asthma Patients., Karen Elizabeth Joseph
Graduate Theses, Dissertations, and Problem Reports (ETD)
The main purpose of this study was to examine the effect of providing allergen-control bedding encasings on encasing utilization for children with asthma and dust mite allergy. Twenty parents of such children were assigned to an intervention group, which received dust mite proof covers upon recruitment, or a control group, which did not. Two to three months after recruitment, parent report and observational measures were obtained during a home visit. The intervention group used the encasings, but not other dust mite control strategies, significantly more than the control group, based on parent report, not observation. Use of dust mite proof …
A Performance Evaluation Of The Mems: An On-Road Emissions Measurement System Study., Benjamin C. Shade
A Performance Evaluation Of The Mems: An On-Road Emissions Measurement System Study., Benjamin C. Shade
Graduate Theses, Dissertations, and Problem Reports (ETD)
A study was conducted to measure brake-specific mass emissions from heavy-duty diesel-fueled engines during their in-use, on-road operation. A Mobile Emissions Measurement System (MEMS) was designed and constructed to accomplish this task. A review of systems from the past 20 years was conducted to determine the limitations of similar systems, to outline the constraints of the MEMS design, and to provide the highest level of accuracy and ruggedness required to withstand the rigors of on-board, on-road testing. None of the systems in the published literature could meet the requirements of such a measurement system. State-of-the-art detectors and sensors were obtained, …
Chicken Lysine α-Ketoglutarate Reductase (Lkr) In Different Tissues And Effects Of Graded Levels Of Dietary Lysine On Lkr And Lysine Oxidation., Megharaja Kandagal Manangi
Chicken Lysine α-Ketoglutarate Reductase (Lkr) In Different Tissues And Effects Of Graded Levels Of Dietary Lysine On Lkr And Lysine Oxidation., Megharaja Kandagal Manangi
Graduate Theses, Dissertations, and Problem Reports (ETD)
To understand tissue participation in lysine oxidation, chicken lysine α-ketoglutarate reductase (LKR) activity and lysine oxidation (LOX) were measured in vitro. LKR activity was measured using a spectrophotometer and LOX was measured by collection of 14CO2 from [U-14C] L-lysine. LKR and LOX were measured in homogenates prepared from liver, kidney, pancreas, heart, brain, lungs, spleen, muscle, and intestine. LKR activities were 1000-fold LOX. LKR activity was highest in liver and intestine each approximately 63 µmoles/(hr*g tissue). Activity in other tissues was significantly greater than zero except for muscle. Muscle, liver, and intestine contributed about 70%, 15% and 6.5% respectively of …
The Relationship Between Administrators' Perceptions Of Part-Time Faculty And Utilization Of Part-Time Faculty At West Virginia Public And Private Colleges And Universities., Susan J. Weaver
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation explores the trends in hiring part-time faculty in West Virginia colleges and universities. The restructuring paradigm places the utilization of part-time faculty within the context of changes in the culture of higher education. Questionnaires were sent to 163 administrators of West Virginia public and private 4-year institutions. Complete responses were received from 134 presidents, vice-presidents for academic affairs, provosts, deans, and in select circumstances, division chairs. There were no significant relationships between the administrator's attitude toward part-time faculty and the administrator's position, years in administration, or years teaching. Attitude toward part-time faculty as measured by the Part-time Faculty …
A Study Of The Relationship Between The Perceived Leadership Style Of Nursing Chairpersons And The Organizational Climate In Baccalaureate Nursing Programs., Nancy Rowland Mosser
A Study Of The Relationship Between The Perceived Leadership Style Of Nursing Chairpersons And The Organizational Climate In Baccalaureate Nursing Programs., Nancy Rowland Mosser
Graduate Theses, Dissertations, and Problem Reports (ETD)
This study examined the relationship between the leadership frames of nursing chairpersons and the organizational climate of nursing departments as perceived by the nursing faculty. Bolman and Deal's Leadership Orientations Instrument (Other), Borrevik's Organizational Climate Description Questionnaire-Higher Education (Partial), and a demographic questionnaire were sent to 605 nursing faculty members in 60 baccalaureate nursing programs in the American Association of Colleges of Nursing North Atlantic Region. A total of 253 usable responses was returned. Descriptive procedures, Pearson's product moment correlation coefficients, one-way analysis of variance, and the General Linear Models Procedure for analysis of variance were used to analyze the …
An Examination Of The Relationship Between Childhood Sexual Abuse, Dissociation, And Eating Disorders., Patricia Marie Bailey
An Examination Of The Relationship Between Childhood Sexual Abuse, Dissociation, And Eating Disorders., Patricia Marie Bailey
Graduate Theses, Dissertations, and Problem Reports (ETD)
Researchers have documented a high percentage of eating disordered individuals with a history of traumatic experiences such as childhood sexual abuse (Abramson & Lucido, 1991; Oppenheimer, Howells, Palmer, & Chaloner, 1985; Tice, Hall, Beresford, Quinones, & Hall, 1989). To what extent these adverse life events may contribute to the onset, maintenance, and severity of maladaptive eating behaviors is widely debated among researchers and clinicians. The present study attempted to identify a spectrum of potentially traumatic life experiences in eating disordered individuals and their relationship with dissociation and eating pathology. Thirty-four female subjects meeting DSM-IV criteria for Bulimia Nervosa (n = …
A Comparison Of The Profiles Of Successful And Unsuccessful Candidates For College Presidencies In The State College System Of West Virginia., Marie Ellen Carter
A Comparison Of The Profiles Of Successful And Unsuccessful Candidates For College Presidencies In The State College System Of West Virginia., Marie Ellen Carter
Graduate Theses, Dissertations, and Problem Reports (ETD)
Candidates (N = 609) for six presidencies in the State College System of West Virginia between 1995 and 1998 were studied and a comparison was made between successful candidates (n = 93) and unsuccessful candidates (n = 516). Successful candidates were defined as those who were judged by the search and screening committees to be best qualified to be interviewed. Candidate application packets and search committee records were the source of data. Independent variables included positions held by candidates at the time of application, baccalaureate graduation dates, education levels, major fields of graduate study, gender, and locations at the time …
The Relation Between Parenting Factors And Social Anxiety: A Retrospective Study., Karla Anhalt
The Relation Between Parenting Factors And Social Anxiety: A Retrospective Study., Karla Anhalt
Graduate Theses, Dissertations, and Problem Reports (ETD)
Various studies have found differences in the socialization experiences of adults with clinical levels of social anxiety, particularly direct and indirect parental influences. This study has expanded the research literature in two ways. First, the unique contribution of several parenting factors to social anxiety was evaluated. Second, participant reports of maternal and paternal child-rearing variables were examined. Four hundred and thirty four undergraduate students at West Virginia University participated in this study. Participants responded to a questionnaire packet that contained the following: (a) a demographic form; (b) the Parent Attitudes Toward Child-Rearing Years (PACR; Bruch, Heimberg, Berger, & Collins, 1989); …
An Examination Of The Multiple Domain Predictor Profiles Of Successful Exercise Behavior In A Health Resort Population., Cheryl Lynn Goldman
An Examination Of The Multiple Domain Predictor Profiles Of Successful Exercise Behavior In A Health Resort Population., Cheryl Lynn Goldman
Graduate Theses, Dissertations, and Problem Reports (ETD)
The present study examined the multiple domain predictor profiles of successful exercise behavior in a health resort population. Successful exercise behavior is operationally defined as maintaining, or changing from a sedentary or somewhat sedentary lifestyle to, an engagement in physical activity at least three times a week for at least twenty minutes each bout (ACSM, 1983). Demographic information, physiological variables, health status and risk factors were assessed at baseline from a sample of repeat guests from a southwestern health and fitness resort. A number of independent variables from each of the three domains were assessed for their ability to predict …
Skeletal Muscle Injury, Fibrosis And Transforming Growth Factor-Beta., Cheryl A. Smith
Skeletal Muscle Injury, Fibrosis And Transforming Growth Factor-Beta., Cheryl A. Smith
Graduate Theses, Dissertations, and Problem Reports (ETD)
Several animal models were assessed for their ability to produce pathology with a potential for developing fibrosis. Pathology was determined using standard histochemical and immunohistochemical techniques. In a model of ethanol-induced myopathy, cytochrome p450 1A1/2 was induced in endothelial cells (i.e. capillaries) but there was insufficient pathology to produce fibrosis. Two models of overload, tenotomy of the gastrocnemius muscle and a tetanus toxin overload model showed morphological changes including: degenerating fibers, central nuclei, variable myofiber sizes, and an expansion of the extracellular matrix, but changes were non-uniformly distributed making this a poor fibrosis model. A tetanus-toxin model of repetitive strain …