Discovering Appalachia As A Political Place: The Influence Of Appalachian Residence And Identification On Presidential Approval And Environmental Policy Preferences, Michael Bancroft Jones

Graduate Theses, Dissertations, and Problem Reports (ETD)

From poets to political scientists, yearning for a sense of place has motivated both song and research. Appalachia is an understudied place in political science, with previous research inconclusive as to whether the Appalachian region has a separate identity from other parts of the United States (White 2019). Identities may be derived from a sense a place. Alternatively, identities may develop from a sense of group identification with common interests and grievances, and concerns regarding out-group members. Appalachia has a long history of being different and set apart from the United States; and also, has been subjected to identity mobilization …

Filling Research Gaps In Occupational Health In Thermal Spray Coatings: A Scoping Review, Lab Characterization, And Lung Deposition Of Cold Sprayed Emissions, Bailley N. Reggetz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Thermal Spray Coating (TSC) processes are industrial surface treatment methods used to create coatings for repair, protection, and performance enhancement of components exposed to wear, corrosion, heat, or other harsh conditions. The most commonly used TSC techniques (flame spraying, electric arc spraying, HVOF spraying, plasma spraying, and cold spraying) are used across numerous industries including aerospace, automotive, biomedicine, and energy due to their ability to enhance surface properties such as providing corrosion resistance, wear resistance, and thermal insulation. While TSC techniques have been commercially available for nearly a century, they have undergone continuous development to accommodate more specialized applications, unique …

Asset Mapping: A Tool Used To Identify Community Resources, Gentry Shrewsbury

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Physical activity is vital for health and quality of life; however, for individuals with disabilities, there are numerous barriers to participation. In rural and low-socioeconomic regions, barriers such as lack of awareness, limited restrooms, and lack of public transportation create challenges when attempting to be physically active. Using the Asset-Based Community Development (ABCD) framework, this study examined physical activity resources within Mercer County, West Virginia, and evaluated their accessibility for individuals with disabilities.

Methods: A qualitative research design was implemented using three data collection strategies: (1) a google search to identify existing physical activity opportunities followed by a windshield …

Nuclear Reactions: Making Sense Of The Accident At Three Mile Island, Jordan Emily Bennett

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis examines the causes and consequences of the nuclear accident at Three Mile Island in March of 1979. First detailing the event, this thesis then examines activist narratives following the accident, with a particular focus on women’s “motherist” activism in the community outside the plant, before turning to questions of memory and the creation of a public memory of survivorship in the community surrounding the plant. In considering these questions, this thesis seeks to shed light on the differences between official and communal narratives of the accident in an effort to understand the impacts that the partial meltdown at …

Revitalizing The Urban Riverfront: Redesigning The West End Bridge In Pittsburgh,Pa For Sustainable Multi-Use Connectivity And Public Space Creation., Mina Kargari Rezapour

Graduate Theses, Dissertations, and Problem Reports (ETD)

Urban waterfronts are critical assets for cities, offering opportunities for ecological restoration, public engagement, and multi-modal transportation. However, many riverfronts remain underutilized due to infrastructure barriers and lack of accessibility.

Pittsburgh’s riverfront is dynamic asset that supports recreation, cultural expression, and community interaction. The Three River Heritage Trail Loop, a visionary project led by River Life over the past 20 years, seeks to connect diverse neighborhoods and natural assets along the city’s rivers. At the heart of this initiative is the West End Bridge, serving as the bookend and a pivotal gateway to complete the loop and critical link for …

Evaluation And Identification Of Novel Viruses In Wild Fishes Using Varied Molecular Biology Techniques, Clayton Douglas Raines

Graduate Theses, Dissertations, and Problem Reports (ETD)

Viruses are among the most abundant biological entities on Earth, yet their diversity and ecological roles in aquatic vertebrates, particularly fishes, remain poorly characterized. This dissertation advances fish virology through integrative approaches that combine historical context, molecular diagnostics, and genomic discovery. A novel hepadnavirus (ApHBV) was identified in asymptomatic Alosa pseudoharengus, emphasizing the prevalence of subclinical infections in migratory forage species. In Catostomus commersonii, transcriptomic profiling revealed sexually dimorphic immune responses to hepatitis B and C-like viruses, highlighting complex host-pathogen dynamics. In Micropterus nigricans, next-generation sequencing uncovered a novel nackednavirus and multiple adomaviruses within hyperpigmented lesions, expanding …

An Analysis Of Usopc National Governing Body Policies Related To Body Pressures, Body Image Concerns, And Eating Pathology, Sarah Margaret Sadler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Athletes are often exposed to body pressures in sport environments (Voelker & Reel, 2020), which can contribute to body image concerns and eating pathology (Petrie & Greenleaf, 2007, 2012) with lasting consequences for performance and well-being. Although research has highlighted the harmful impacts of these concerns, and has called for a broader investigation into the sources of athletes’ experiences of these concerns (Voelker et al., 2022), little is known about the role of sport organizations in influencing athletes’ body pressures, body image concerns, and eating pathology. Using a descriptive qualitative research design within a post-positivist paradigmatic approach, the current study …

Neurobiological Variables Mediating The Relationship Between Breast Cancer And Sleep Disruption, Brittany Domenique Elliott

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neurobiological Variables Mediating the Relationship between

Breast Cancer and Sleep Disruption

Brittany D. Elliott, MS

Breast cancer is the most commonly diagnosed malignancy in women, with more than two million new cases diagnosed world-wide each year. Improvements in screening technology and diagnostics have increased survival rates, but cancer-associated sleep disruptions persist for the majority of breast cancer survivors well beyond the treatment period. In addition to reducing quality of life, reduced sleep quality is associated with greater incidences of affective dysfunction, reduced treatment efficiency, aggressive cancer progression, increased symptom severity, and increased mortality by all causes. Thus, identifying the variables …

Non-Lethal Sampling Methods For Fish Health Assessments Using Smallmouth Bass Micropterus Dolomieu, Lindsey Nicole Hartzell

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the early 2000s, fish kills of different species, including smallmouth bass Micropterus dolomieu, were reported in areas of the Potomac River drainage, including the Shenandoah River in Virginia. Since the first reports of fish kills and lesions affecting smallmouth bass, they have continued to show signs of adverse health effects. Additionally, in some areas of the Potomac River drainage, population declines have occurred, and lethal sampling is discouraged. To develop a holistic, integrative approach to assess fish health, Smallmouth Bass were collected and sampled using non-lethal techniques at three sites within the Shenandoah River drainage, VA and one …

Longitudinal And Ensemble Modeling Of Beef Cattle Feed And Water Intakes, Nathan El Blake

Graduate Theses, Dissertations, and Problem Reports (ETD)

Beef cattle production remains a cornerstone of global food systems, providing highly bioavailable protein and essential micronutrients that are difficult to secure from plant-based foods alone. Yet this production is also resource-intensive, requiring substantial land, feed, and water inputs while contributing significantly to greenhouse gas emissions. Efficiency of dry matter intake (DMI) and water intake (WI) is central to both productivity and sustainability, but accurate measurement of these traits—particularly in grazing systems—remains a major limitation. National WI standards continue to rely on pen-level data collected in the 1950s, while most existing DMI prediction equations perform poorly when applied beyond the …

Assessing And Predicting The Impact Of A Retrofitted Methane Mitigator On Non-Road Large Natural Gas Engines Using Artificial Neural Networks, Augustine Thomas Ojo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

ASSESSING AND PREDICTING THE IMPACT OF A RETROFITTED METHANE MITIGATOR ON NON-ROAD LARGE NATURAL GAS ENGINES USING ARTIFICIAL NEURAL NETWORKS

Augustine Thomas Ojo

Methane emissions from the oil and gas sector present a pressing environmental and economic challenge, given methane’s high global warming potential and the considerable volumes of unutilized gas lost from industrial processes. This study investigates the impact of a retrofitted methane mitigation system, the Methane Mitigator (M²), on fuel consumption and engine-out emissions in non-road, four-stroke natural gas-powered, lean-burn engines and develops predictive Artificial Neural Network (ANN) models to estimate the resulting engine-out emissions and fuel …

Microbial And Plant Biodiversity In Appalachian Agroecosystems And Their Implications For Soil Health, Kinsey Reed Close

Graduate Theses, Dissertations, and Problem Reports (ETD)

The sustainability of agricultural landscapes depends on understanding the complex interactions between plants, soil, and microbes. In Appalachia, a region shaped by complex terrain and long histories of human and ecological interaction, small family farms produce hay, livestock, and row crops. These agroecosystems, though often treated as “artificial” by many ecologists, have the potential to support both food production and biodiversity conservation if managed with an understanding of ecological complexity. This dissertation examines how plant and microbial diversity interact with soil and management to influence nutrient cycling, soil health, and long-term resilience in Appalachian agricultural systems. A literature review revealed …

Synthetic Data–Driven Early Prediction Framework For Acute Kidney Injury In Patients Receiving Vancomycin And Ceftazidime/Avibactam, Maryam Ramazani

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: The nephrotoxic risks of combining ceftazidime/avibactam (AVI) with vancomycin (VAN) remain underexplored, despite both agents independently being linked to acute kidney injury (AKI). This study assessed the risk of AKI associated with concurrent VAN and ceftazidime/avibactam (VAN-AVI) therapy and developed synthetic data models to enable early prediction of AKI.

Methods: We conducted a retrospective analysis using electronic health record data from hospitalized adults between 2015 and 2022. The incidence of AKI was compared among patients receiving VAN-AVI or VAN in combination with piperacillin/tazobactam (VAN-TPZ) versus VAN monotherapy. AKI was defined as a composite of de novo and recurrent AKI …

Toward A University-Led Community Indicator Project For West Virginia, Daniel Carson Eades

Graduate Theses, Dissertations, and Problem Reports (ETD)

Rural communities across the United States are experiencing profound social and economic transitions that demand innovative, asset-based approaches to community development (CD). This study responds to calls from West Virginia (WV) community development practitioners, funders, and university leaders for a standardized, contextually relevant framework to assess and track community well-being. The objective of this study was to develop a university-led community indicator project in West Virginia (WV CIP) that incorporates best practices recognized by the literature as critical to successful community-based indicator projects, specifically, the identification of scientifically and normatively grounded indicators rooted in a conceptual framework (the Community Capital …

Synergetic Effect Of Cellulose And Chitosan Polymers In Cancer Treatment, Grace Peterson

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research explores the development of a biocompatible, natural drug delivery system designed for targeted cancer therapy. Lung cancer cells are used in these particular tests, but further research indicates treatment could be used for various cancer types. Traditional cancer treatments like chemotherapy are often limited by poor selectivity for tumor cells, causing significant damage to healthy tissues. The study proposes a dual-layered delivery system, utilizing Carboxymethyl Cellulose (CMC) as the core material and a charge-reversible chitosan shell to encapsulate and target cancer drugs. CMC, with its water solubility and ability to form stable gels, serves as a stable drug …

Rational Design Of Small Molecules Targeting Mitochondrial Redox Proteins, Matheus Barbosa Belchior

Graduate Theses, Dissertations, and Problem Reports (ETD)

Reactive oxygen species play a crucial role in many cellular processes. Despite being a natural byproduct of cellular metabolism, overexpression of these species causes damage to the cell, leading to cell dysfunction. Central to the regulation of these highly reactive molecule is the mitochondria. Impairment in its function has been associated with oxidative stress within the cell. Herein, a ligand-based and structure-based approach to design new small molecules to inhibit mitochondrial redox proteins associated with oxidative stress and reactive oxygen species. In the first project two molecules were synthesized and characterized as potential monoamine oxidase B inhibitors. Results showed two …

Identifying The Role And Influence Of Interleukin-27 On The Neonatal Immune Response, Jordan Kane Vance

Graduate Theses, Dissertations, and Problem Reports (ETD)

The first month of life is a critical and vulnerable developmental stage, characterized by a heightened risk of life-threatening infections. Each year, 1.3 million newborns succumb to neonatal bacterial sepsis. The immune system during the neonatal period has unique features that lead to inefficiencies at clearing infection. Early life immunity is characterized by a Th2-biased profile with decreased IL‑12, IFN-γ, and TNF-α, along with increased IL‑6 and IL‑23. Additionally, IL‑27, an immunosuppressive cytokine, is also elevated during this period and further contributes to susceptibility to infection. Early diagnosis and intervention are critical in administering effective care in newborns and there …

A Difference-In-Differences Investigation Of The Impact Of State-Mandated Campus Carry Laws In Texas On Violent Campus Crime Rates, Ryan Matthew Gibson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study is to examine the potential impact of state-mandated campus carry laws on sexual misconduct and other violent crime statistics at public, four-year institutions. The study focuses on the state-mandated campus carry law put into effect in Texas starting in 2016 to analyze whether or not it had an impact on campus crime rates. Findings of the study showed that reported campus crime increased at Texas institutions post-2016 at a larger rate than the states that explicitly ban campus carry. Due to a lack of data on the number of individuals carrying guns on campuses in …

Exploring The Ruminal Microbiome And Its Impacts On Feed Efficiency In Beef Cattle, Taylor Simone Sidney

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ability for beef cattle to utilize feed efficiently is a critical determinant for both economic and environmental sustainability in livestock production. However, despite extensive research, the complex microbial ecosystem within the rumen and its relationship to feed efficiency remain incompletely understood. This dissertation explores the physiological and microbial foundations of feed efficiency by characterizing how rumen microbial communities and their functions differ among beef cattle with divergent residual feed intake (RFI) phenotypes and how the RFI status of beef cattle influenced their response to dietary interventions such as supplementation with a Bacillus-based feed additive. In the first study, …

Pancreatic Cancer In Appalachia: An Examination Of Detection, Associated Factors, And Provider Experiences With A Focus On West Virginia, Melissa Mae Elder

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Pancreatic Cancer in Appalachia: An Examination of Detection, Associated Factors, and Provider Experiences with a Focus on West Virginia

Melissa M. Elder

Introduction: The Appalachian population accounts for a substantial proportion of the United States and are uniquely susceptible to health care disparities. The Appalachian Regional Commission has reported on the inequities found within the Appalachian region as part of its formal establishment in 1965. When compared to the Non-Appalachian U.S., Appalachia experiences a higher incidence of chronic disease such as diabetes, cancer, lung, and liver disease; mortality from diseases of despair constituting prescription drug, alcohol, illegal drug use, …

Probing The 10-23 Dnazyme Catalytic Core: Insights From Structural And Mechanistic Studies, Evan Rhyse Cramer

Graduate Theses, Dissertations, and Problem Reports (ETD)

The 10-23 DNAzyme is a catalytically active DNA oligonucleotide capable of cleaving RNA at purine-pyrimidine junctions in the presence of divalent metal ions, most notably magnesium. Despite its promise as a programmable RNA knockdown tool, its clinical and biotechnical utility has been hampered by limited structural characterization, low catalytic efficiency under physiological conditions, and poor understanding of its in-cell activity. This dissertation presents a comprehensive framework for the structural and functional analysis of DNAzymes using the 10-23 DNAzyme as a model system. In the absence of high-resolution structures, we first employed detailed in vitro biochemical assays to map essential residues …

Access And Entitlement: Investigating The Contours Of Public Health In Late Colonial Bengal And Post Colonial West Bengal (1920-1960), Ametasree Bhattacharya

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation employs the comparative framework of “Access and Entitlement,” which serves as a metric to measure the goods and services the state could responsively provide to the public. It utilizes this framework to analyze the realm of public health in Bengal/West Bengal before and after decolonization. The main body is divided into two parts: the first three chapters focus on malaria, and the last three on nutrition. The first chapter explores debates over malaria control between 1919 and 1935. The second examines anti-malarial efforts from 1935 to 1947, emphasizing the influence of communal politics and the Second World War …

This Is A War: The 1977-78 Coal Strike And The Fracturing Of The Postwar Social Compact, Christian B. Rowe

Graduate Theses, Dissertations, and Problem Reports (ETD)

The 1977–78 coal strike was a landmark moment for the American labor movement. Despite holding out for 110 days with no pay or benefits through a historically severe winter, miners were unable to advance their demands and achieve a progressive contract. By invoking the Taft–Hartley Act to end the strike, Jimmy Carter destabilized the New Deal political coalition by enraging one of its core constituencies and placing the needs of the state over the needs of unionized industrial workers. The BCOA’s immovable position in negotiations was an early sign that the labor-management accord that had governed industrial relations since World …

Development Of A Model To Estimate Engine Crankcase Methane Vent Emission Rates, Juan Pablo Rincon

Graduate Theses, Dissertations, and Problem Reports (ETD)

The primary focus of this research is the modeling and validation of crankcase methane emissions stemming from natural gas combustion engines commonly deployed in the natural gas compression industry. The models employed rely on equations predicting the flow rate and composition of losses, typically generated within reciprocating piston-cylinder systems. Since crankcase emissions originate in a piston–cylinder arrangement, multiple variables were considered in this study, including displaced volume, pressure, temperature, flow, and viscosity (with corrections applied to account for the thermal and compositional effects on the mixture of fluids). The initial data for this research was collected during three measurement campaigns …

Trauma-Informed Yoga As An Adjunct To Treatment As Usual Within Inpatient Substance Use Disorder Treatment: A Feasibility Trial., Suzanne Vogler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Yoga interventions have been used more frequently in recent years within health and wellness settings to address both clinical and non-clinical issues. More specifically, yoga interventions and trauma-informed yoga (TIY) interventions are being explored within the treatment of substance use disorders (SUD). Initial research suggests that yoga interventions could be beneficial to the treatment of SUDs as an adjunct to treatment or a stand-alone intervention as part of continued recovery (post-clinical treatment) (Fitzgerald et al., 2021; Mallik et al., 2019). Although initial research is promising, the current quantity and quality of studies specifically exploring the feasibility and potential benefit of …

Watershed-Level Survey Of Antimicrobial Resistance From Onsite Wastewater Systems, Trey Franklin Clark

Graduate Theses, Dissertations, and Problem Reports (ETD)

The emergence of antimicrobial resistance (AMR) has quickly become one of the largest global health and development threats. Research related to environmental modes of transmission of AMR has accelerated in recent years, and the US Environmental Protection Agency is particularly interested in this emerging contaminant. Knowledge of how onsite (decentralized) wastewater treatment systems contribute to this issue is lacking, so this research serves to analyze and quantify the environmental dissemination of AMR and fecal contamination from these sources at a watershed level while using statistical analysis to assess relationships between physiochemical, spatial, and sampling parameters. This research surveyed four watersheds …

A Learning History Of A State Physical Activity Plan, Jessica Nicole Riffee

Graduate Theses, Dissertations, and Problem Reports (ETD)

Physical inactivity remains a persistent public health concern in the United States, disproportionately affecting rural populations like West Virginia. To address statewide physical activity challenges, West Virginia developed one of the nation’s first state level physical activity plans, ActiveWV: 2015, that was revised to ActiveWV: 2030. Limited research has investigated how statewide physical activity plans unfold over time or how stakeholder learning can drive improvement.

This dissertation employed a learning history action research methodology to construct a collective narrative of the development, dissemination, implementation, and evaluation activities across both iterations of the West Virginia Physical Activity Plan. Reflective interviews with …

Development Of Novel Carbohydrate-Based Nanoparticles For Precision Drug Delivery, Krystal Ann Hughes

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nanoparticle-based drug delivery has made tremendous advancements in the last decade. However, several critical factors, including precision drug delivery at the site of interest, long-term storage stability, and controlling release profiles of drugs in the systemic circulation, need to be addressed for successful clinical translation of nanomedicine. This dissertation presents novel carbohydrate-based nanoparticles that achieve precise intracellular delivery and therapeutic release at the disease site. We present the formulation and optimization of polymeric and polymer-lipid hybrid nanoparticles that enable precision intracellular delivery and passive accumulation of therapeutics in the bone marrow. Intracellular delivery is highly impactful and sought after. One …

Developing The 21st Century Piano Studio, Brianna Mae Eddy

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study explores the needs of the contemporary piano studio, including business policies, the use of technologies, mental health and neurodivergence in students, and the influence and use of social media. Focused on the needs of both the private-studio piano teacher and traveling piano teacher, the paper offers insight into studio ownership and management with an emphasis on providing experiences that meet the needs of contemporary students. The paper includes a brief history of private piano instruction as well as information for developing studio policies, business issues related to current tax requirements and forms, and resources for financial and general …

A Qualitative Analysis Of Secondary Mathematics Teachers’ Development Toward Teaching Mathematics For Social Justice, Catherine Lynne Manley

Graduate Theses, Dissertations, and Problem Reports (ETD)

While some might say that mathematics is neutral, free from political and social bias, social justice concerns can be found in the day-to-day actions of teachers in mathematics classrooms. Teaching mathematics for social justice requires teachers to gain knowledge of the world and systems of oppression as well as current efforts to both address systemic issues as well as the fight for those in power to maintain their cultural capital. Mathematics teachers also need to learn the pedagogical practices that support social justice in education and the specific ways in which mathematics content can be used as a tool to …