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An Interactive Mobile Equipment Task-Training With Virtual Reality, Lazar Zujovic
An Interactive Mobile Equipment Task-Training With Virtual Reality, Lazar Zujovic
Graduate Theses, Dissertations, and Problem Reports (ETD)
Improving the quality of equipment training for the Heavy Equipment Operators (HEO) is a critical task in the ever-lasting effort to improve safety and eliminate equipment-related injuries in mining environments. Traditional miner training includes the use of hardcopy documents and video instructions. However, modern mobile and computer technology offers tremendous potential to improve the training process. One major responsibility for the heavy-machine operators is proper machine inspection. Establishing new training methods that utilize modern technologies—such as 360-degree images, videos, and Virtual Reality—and implementing computers for training purposes have a potential to help new operators learn how to conduct proper machine …
Women Veterans’ Descriptions Of The Patient-Provider Interaction With Civilian Providers, Billie S. Vance
Women Veterans’ Descriptions Of The Patient-Provider Interaction With Civilian Providers, Billie S. Vance
Graduate Theses, Dissertations, and Problem Reports (ETD)
BACKGROUND: Women veterans require care for unique gender, and war-related health issues. Concerns exist regarding non-Veterans Health Administration (VHA), civilian healthcare providers’ preparedness to deliver care to the veteran population. Health outcomes are influenced by the quality of care provided to patients. There is a significant gap in the literature with regard to woman veterans’ perspectives about the quality of the patient-provider interaction between women veterans and non-VHA, civilian providers.
PURPOSE: The purpose of this study was to describe women veterans’ perspectives about interactions between themselves and civilian providers and to critically analyze the veterans’ data to further inform the …
Evaluation Of The Impact Of An Educational Intervention Aimed At Improving Tuberculosis Infection Control Knowledge Among Health Care Workers In A Military Treatment Facility: A Quality Improvement Project, Allen C. Potter
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background: Florida (FL) is one of the top five states in the nation for Tuberculosis (TB) infections. A majority of new infections can be found in the minority populations which represents 78% of all TB infections in the state. A combination of TB rates in FL, Orlando located 60 miles away and a transient population who frequently deploys worldwide to austere locations may result in an increased risk of acquiring TB. Literature suggests Health Care Providers (HCPs) obtain training regarding TB Infection Control (TB-IC). The Patrick AFB Military Treatment Facility (MTF) lacked a TB Infection Control (TB-IC) plan. Objective: The …
Development Of An Activity-Based Windowing Approach To Evaluate Real-World Nox Emissions From Modern Medium And Heavy-Duty Diesel Trucks, Rasik Pondicherry
Development Of An Activity-Based Windowing Approach To Evaluate Real-World Nox Emissions From Modern Medium And Heavy-Duty Diesel Trucks, Rasik Pondicherry
Graduate Theses, Dissertations, and Problem Reports (ETD)
The introduction of in-use emissions regulations by the United States Environmental Protection Agency (U.S.EPA) requires medium-duty (MD) and heavy-duty (HD) engine manufacturers to demonstrate emissions compliance during in-fleet operation. In the United States (U.S.), the Not-to-Exceed (NTE) method is used to evaluate real-world emissions compliance from on-highway MD and HD trucks. Regulatory agencies, engine manufacturers and research entities have identified that the NTE method incorporates numerous exclusions and evaluates emissions compliance only under selective operating conditions that are favorable for the selective catalytic reduction (SCR) system to reduce oxides of nitrogen (NOx) emissions efficiently. Such operation is typically encountered only …
The Influence Of Spatial Variance On Rock Strength And Mechanism Of Failure, Danqing Gao
The Influence Of Spatial Variance On Rock Strength And Mechanism Of Failure, Danqing Gao
Graduate Theses, Dissertations, and Problem Reports (ETD)
The heterogeneity in the rock formation affects both rock behavior and the strength. The effect of heterogeneity is observed both at the laboratory scale and at the rockmass level. The mechanical properties of intact rock vary considerably at laboratory scale and often an average value is used for design purposes. Similarly, the values are arbitrarily scaled when used at rockmass level. In underground coal mines, the effect of variability of properties is often observed with the erratic roof failure events that occur throughout the mine. The approach often was to use the deterministic values from limited site data to estimate …
The “Other” Teacher: Understanding The Experience Of Graduate Teaching Assistants In Neoliberal Teacher Education Settings, Jing Zhang
Graduate Theses, Dissertations, and Problem Reports (ETD)
In this study, I critically examine how graduate teaching assistants’ (GTAs’) experiences are discursively shaped by the exercise of power in neoliberal higher education contexts and hence, to reveal the hidden aspects of educational institutions, which are central to our understandings about the meaning of truth, fairness, and equity embedded in neoliberal academic settings. To understand the experiences of graduate teaching assistants in this neoliberal teacher education setting, the major research questions of this study explore how the different identities that GTAs possess influence their interactions with the neoliberal higher education context and how they navigate as well as resist …
Barriers And Facilitators Of Seeking Psychological Help For Muslims In The United States, Sarah R. B. Milam
Barriers And Facilitators Of Seeking Psychological Help For Muslims In The United States, Sarah R. B. Milam
Graduate Theses, Dissertations, and Problem Reports (ETD)
Due to increased social, cultural, and political struggles for Muslims in the United States (MUS), affordable, accessible, and culturally appropriate mental health care is important for these individuals (Aloud & Rathur, 2009). MUS are an underrepresented group that use mental health services at low rates (Ciftci, Jones, & Corrigan, 2013; Khan, 2006). MUS, especially those with mental health concerns, hold a number of stigmatized identities, often including their race and ethnicity, religion, and mental health status that can result in discrimination (Ciftci et al., 2013). The purpose of this study was to examine factors related to self-stigma for seeking psychological …
Advancing Quantitative Understanding Of Escherichia Coli Concentrations In A Contemporary Mixed Land-Use Watershed, In West Virginia, Usa, Fritz Petersen
Advancing Quantitative Understanding Of Escherichia Coli Concentrations In A Contemporary Mixed Land-Use Watershed, In West Virginia, Usa, Fritz Petersen
Graduate Theses, Dissertations, and Problem Reports (ETD)
A scarcity of field-based research investigating the relationships between E. coli (fecal matter) concentration, suspended particulate matter (SPM; including size distribution), physicochemical parameters (water temperature, pH, SPC, DO, chloride) and land use practices and the importance of these relationships, particularly for human health, policy makers, and water resource managers, provided the impetus for this research. A 22-site, nested-scale, experimental watershed study design was implemented to investigate E. coli concentrations and the aforementioned relationships in a contemporary mixed land use watershed in the Appalachian region of the eastern United States. Results from a reduced (n=4 sites) study showed SPM in the …
The Role Of High-Fat Diets In Exacerbating Cognitive Deficits After Traumatic Brain Injury, Michelle A. Frankot
The Role Of High-Fat Diets In Exacerbating Cognitive Deficits After Traumatic Brain Injury, Michelle A. Frankot
Graduate Theses, Dissertations, and Problem Reports (ETD)
Traumatic brain injury (TBI) can cause chronic psychiatric-like impairments that may be driven by inflammation in the brain. In the current study, inflammation was upregulated using a high-fat diet (HFD) to assess the role of inflammation in TBI-induced deficits. Rats were randomly assigned to receive an HFD or calorie-matched low-fat diet (LFD) for the duration of the experiment. After two weeks of free access to their respective diets, rats began behavioral training on the Rodent Gambling Task (RGT), during which they were allowed to freely choose to nosepoke in one of four holes in a standard operant chamber. Responses in …
Evidence Of Y Chromosome Long Non-Coding Rnas Involved In The Radiation Response Of Male Non-Small Cell Lung Cancer Cells, Tayvia Brownmiller
Evidence Of Y Chromosome Long Non-Coding Rnas Involved In The Radiation Response Of Male Non-Small Cell Lung Cancer Cells, Tayvia Brownmiller
Graduate Theses, Dissertations, and Problem Reports (ETD)
Non-small cell lung cancer (NSCLC) is the number one cause of cancer related mortality in the United States and worldwide. Advanced and therapeutically resistant lung tumors contribute to the high rate of mortality from NSCLC, therefore there is a need for new methods of diagnosing and treating this disease. Long non-coding RNAs (lncRNAs) have been shown to be a crucial component of human molecular biology, regulating nearly every cellular pathway from chromatin condensation to transcription and translation. Furthermore, many lncRNAs have been classified as oncogenes or tumor suppressors, highlighting the various molecular mechanisms they are involved in regarding the formation …
The Impact Of The Global Financial Crisis On Visitation To The Monongahela National Forest: An Activity-Based Segmentation Approach, Connor Braxton Akers
The Impact Of The Global Financial Crisis On Visitation To The Monongahela National Forest: An Activity-Based Segmentation Approach, Connor Braxton Akers
Graduate Theses, Dissertations, and Problem Reports (ETD)
Research on recreational use market segments and trends are essential for determining how tourism businesses can better meet the needs of their customers and find new target markets especially during challenging times. The purpose of this study is to determine how recreation participation has changed over five years on the Monongahela National Forest following the world financial crisis in 2008. Data used for this research were collected with the National Visitor Use Monitoring (NVUM) surveys in fiscal years 2009 and 2014. NVUM surveys are onsite interviews conducted at the end of a visit. The surveys produce descriptive information about visitors. …
Morally Injurious Experiences Of Combat Exposed Veterans Of Iraq And Afghanistan: Moderating Effects Of Self-Forgiveness On Feelings Of Shame And Guilt, Timothy Swiger
Graduate Theses, Dissertations, and Problem Reports (ETD)
Moral injury is a construct developed to explain a unique symptom profile of individuals who may have perpetrated, witnessed, or learned about events that transgress their held moral beliefs. Among combat exposed Veterans, particular attention has been focused on the ambiguous nature of recent military conflicts and the increased moral conflicts associated with more recent, unconventional combat tactics and strategies. This study examined the relationship between moral injury and feelings of shame and guilt among a large sample (n=198) of Veterans who deployed in support of conflicts in Iraq and/or Afghanistan. Additionally, this study sought to examine self-forgiveness …
Multimorbidity, Immune Checkpoint Inhibitor Use, And Healthcare Expenditures Among Older Patients With Late-Stage Melanoma, Pragya Rai
Graduate Theses, Dissertations, and Problem Reports (ETD)
With decades of unchanged cancer care with no added survival benefit, immune checkpoint inhibitors (ICI) changed the treatment landscape of late-stage melanoma in 2011. A key factor in determining the use of ICIs is the presence of pre-existing chronic conditions, which can influence the outcome. However, the prevalence of multimorbidity (defined as presence of two or more chronic conditions) among older patients with late-stage melanoma remains unknown. It also remains unknown if the presence of multimorbidity factors into the use of ICIs. Hospital-related factors associated with ICI use have been studied. Yet, patient-level factors, such as age, sex, marital status, …
Examining Provider-Patient Communication And Family Knowledge Of Treatment In Pediatric Asthma Care, Thomas W. Ewell
Examining Provider-Patient Communication And Family Knowledge Of Treatment In Pediatric Asthma Care, Thomas W. Ewell
Graduate Theses, Dissertations, and Problem Reports (ETD)
Asthma knowledge is an essential factor in being able to consistently and effectively manage asthma symptoms over time, which in turn reduces asthma morbidity and improves quality of life. The way in which certain provider factors, such as communication strategies or techniques, may differentially impact pediatric patients and their caregivers has little in the way of prior investigation. The current study involves a secondary analysis from a larger project. This larger study included 45 pediatric asthma patients (ages 8-17 years; M = 11.79) and their primary caregiver recruited from pediatric asthma and allergy clinics within the WVU Medicine system to …
Performance Study Of Five Different Cabin Air Filters In The Laboratory And On-Road Drive, Fahad Alqahtani
Performance Study Of Five Different Cabin Air Filters In The Laboratory And On-Road Drive, Fahad Alqahtani
Graduate Theses, Dissertations, and Problem Reports (ETD)
One of the aims of installing ventilation filters in a car is to prevent vehicle occupants from inhaling potentially harmful aerosols emanating from the environment. Vehicle cabin filters are essential in ensuring that a vehicle's air conditioning system provides clean air to its occupants. The purpose of the cabin filter is to improve air quality inside the car to provide better comfort and better protect occupants from experiencing unwanted respiratory problems. Using cabin filters in air conditioning systems is a common practice in modern vehicle manufacturing. Scientists and engineers are continually seeking new ways of improving the efficiency and effectiveness …
Fracture Resistance Of Simulated External Cervical Resorption In Anterior Teeth Restored With And Without A Fiber Post., Michelle M. Romeo
Fracture Resistance Of Simulated External Cervical Resorption In Anterior Teeth Restored With And Without A Fiber Post., Michelle M. Romeo
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction: External cervical resorption (ECR) is a destructive type of external resorption that can be difficult to treat. ECR usually begins subgingival at the cementoenamel junction of teeth and continues apically and circumferentially. This substantial loss of tooth structure may make these teeth more prone to fracture and should be addressed when treatment planning teeth with ECR. The aim of this in vitro study was to evaluate the fracture resistance of treated and non-treated teeth with simulated ECR using two different treatment modalities.
Materials and Methods: Forty-eight extracted human permanent mandibular central incisors were selected. Teeth were randomly divided into …
Effect Of Western Diet And Caloric Substitution With Apple Pomace On Fatty Acid Composition And Gene Expression In The Hypothalamus Of Growing Female Sprague-Dawley Rats, Ayad Abdulhamid Alawadi
Effect Of Western Diet And Caloric Substitution With Apple Pomace On Fatty Acid Composition And Gene Expression In The Hypothalamus Of Growing Female Sprague-Dawley Rats, Ayad Abdulhamid Alawadi
Graduate Theses, Dissertations, and Problem Reports (ETD)
The hypothalamus plays a major role in regulating food-intake and energy-expenditure. Hypothalamic dysfunction implicated in neurodegenerative diseases is characterized by diet-induced neuroinflammation and energy dysregulation. Apple pomace, a waste byproduct of processing, is rich in polyphenols and soluble fibers, has the potential to ameliorate diet-inducing inflammation. The objective of this study was to determine the effects of Western diet and caloric substitution of Western diet with 10% apple pomace on brain fatty acid composition and gene expression related to hypothalamic function and health in growing female rats. Growing female Sprague-Dawley rats (age 22-29 days) were randomly assigned (n=8 rats/group) to …
Using Ai And Machine Learning To Indicate Shale Anisotropy And Assist In Completions Design, Cole E. Palmer
Using Ai And Machine Learning To Indicate Shale Anisotropy And Assist In Completions Design, Cole E. Palmer
Graduate Theses, Dissertations, and Problem Reports (ETD)
Operating companies in the unconventional Marcellus shale play have all faced a similar and problematic issue, while attempting to produce natural gas over the last decade. Companies have quickly realized that not every perforation along their horizontal wells are producing gas. In fact, producing perforations are only ranging from 15%-70% of the total perforations along the horizontal wellbore [1]. This unexplained issue results in millions of dollars in lost revenue per well, in addition to the sunk cost of paying for completions that are not actually yielding any produced gas.
What is causing these perforations to have no produced gas? …
A Study Of Impact Protection Of Metacarpal Gloves, Faisal Mohammed Alessa
A Study Of Impact Protection Of Metacarpal Gloves, Faisal Mohammed Alessa
Graduate Theses, Dissertations, and Problem Reports (ETD)
Work-related wrist, hand, and finger injuries are highly prevalent in manufacturing and extractive industries. An analysis of mining-related hand injury data from over the past two decades (Alessa et al., 2020) showed that hand injuries caused by insufficient protection against impact loads (e.g. struck by accidents) were categorized with high severity. Existing literature lacks clear classification and quantification methods for the protection provided by impact-resistant gloves (i.e. metacarpal gloves). A new method to establish a quantitative measure of performance for commonly used metacarpal gloves was developed and evaluated.
In the first specific aim, an experimental study using cadaveric hand specimens …
Applications Of Machine Learning Methods In Health Outcomes Research: Heart Failure In Women, Khalid Abdullah Alhussain
Applications Of Machine Learning Methods In Health Outcomes Research: Heart Failure In Women, Khalid Abdullah Alhussain
Graduate Theses, Dissertations, and Problem Reports (ETD)
There is robust evidence that heart failure (HF) is associated with substantial mortality, morbidity, poor health-related quality of life, healthcare utilization, and economic burden. Previous research has revealed that there are sex differences in the epidemiology, etiology, and disease burden of HF. However, research on HF among women, especially postmenopausal women, is limited. To fill the knowledge gap, the three related aims of this dissertation were to: (1) identify knowledge gaps in HF research among women, especially postmenopausal women, using unsupervised machine learning methods and big data (i.e., articles published in PubMed); (2) identify emerging predictors (i.e., polypharmacy and some …
Microfinance In Latin America: Poverty Alleviation And The Impact Of Institutional Mimicry, Lindsay Jouben
Microfinance In Latin America: Poverty Alleviation And The Impact Of Institutional Mimicry, Lindsay Jouben
Graduate Theses, Dissertations, and Problem Reports (ETD)
Microfinance has become a program of choice in the international development community. The World Bank has promoted microfinance programs under the idea that poverty alleviation can be accomplished by mainly providing credit. [1] As such, these policies are often replicated throughout the developing world. This replication is done through international organizations adopting a standard of best practices for the microfinance field. Best practices consist of a complex set of standard by which all banks must adhere if they receive funding from the World Bank or International Monetary Fund. These best practices, following neoliberal economics, lay out how microfinance should operate …
A Spatially Distributed Investigation Of Stream Water Temperature In A Contemporary Mixed-Land-Use Watershed, Jason P. Horne
A Spatially Distributed Investigation Of Stream Water Temperature In A Contemporary Mixed-Land-Use Watershed, Jason P. Horne
Graduate Theses, Dissertations, and Problem Reports (ETD)
Stream water temperature is an important physical variable that influences many biological and abiotic water quality processes. The land-use/land-cover (LULC) types and corresponding variability in stream water temperature (Tw) processes in contemporary mixed-land-use watersheds necessitate research to advance management and policy decisions. Water temperature was analyzed from 21 gauging sites using a nested-scale experimental watershed study design. Results showed that forested land use was significantly negatively correlated (α = 0.05) with mean and maximum Tw. Agricultural land use was significantly positively correlated (α = 0.05) with maximum Tw except during the spring season. Mixed development and Tw were significantly correlated …
Investigation Of Molecular Functions Of Zinc Finger Protein (Znf71) In Non- Small Cell Lung Cancer, Rehab O. Mohamed
Investigation Of Molecular Functions Of Zinc Finger Protein (Znf71) In Non- Small Cell Lung Cancer, Rehab O. Mohamed
Graduate Theses, Dissertations, and Problem Reports (ETD)
Non-small cell lung cancer (NSCLC) is the first cause of tumor-related death worldwide. Despite the advancement in surgical and medical treatment, the prognosis of the disease remains poor1. To date, there is no available molecular assay to predict the benefit of therapy or tumor recurrence 2. ZNF71 was reported in our previous study, which identified a 7-gene predictive signature for the clinical benefit of chemotherapy and prognosis in NSCLC2. The study concluded that patients who have higher ZNF71 protein expression have better survival. For this reason, we decided to study the molecular function of ZNF71 and how it may affect …
West Virginia Dentists' Perception Of The Knowledge And Skills Of Two Vs. Four Year Dental Hygiene Graduates, Kaitlyn M. Mcquain
West Virginia Dentists' Perception Of The Knowledge And Skills Of Two Vs. Four Year Dental Hygiene Graduates, Kaitlyn M. Mcquain
Graduate Theses, Dissertations, and Problem Reports (ETD)
The entry level for the dental hygiene profession has, historically been an associate degree. In 2016 the American Dental Hygiene Association (ADHA) approved the Bachelor’s Degree level of education as the preferred for entry level degree. This study is to determine practicing West Virginia dentists preference for the education level of their entry-level dental hygiene employees. There were 1020 surveys electronically distributed to practicing WV dentists to obtain their opinions and preferences. WVU Research Electronic Data Capture (REDCap) was used to determine response percentages and Chi-square statistics were used to compare 2017 to 2019 response rates. Between 2016-2017 and 2018-2019, …
Review Of Established And Emergent Methods For The Production Of C4 Olefins, James Matthew Koval
Review Of Established And Emergent Methods For The Production Of C4 Olefins, James Matthew Koval
Graduate Theses, Dissertations, and Problem Reports (ETD)
Current production of C4 olefins is dominated by naphtha cracking and butane dehydrogenation, but significant research interest is developing in alternate feedstocks due to an abundance of inexpensive natural gas and bioethanol. The current C4 olefin production methods are costly, make use of already-depleted petroleum resources, and are often hazardous to workers, which forms the impetus for investigation into alternative methods and assessment of their viability as a future means of olefin production. Methods of natural gas conversion to higher order hydrocarbons are discussed, including Fischer-Tropsch synthesis and oxidative methane coupling, each of which could form the first …
Relation Between Depression Symptoms And Suicide Risk In Adults And Older Adults, Ruifeng Cui
Relation Between Depression Symptoms And Suicide Risk In Adults And Older Adults, Ruifeng Cui
Graduate Theses, Dissertations, and Problem Reports (ETD)
Suicide consistently ranks among the top 10 leading causes of death in the United States. Depressive disorders as well as depression symptoms are risk factors for suicide. Depression symptoms typically fall under a cognitive affective domain and a somatic domain. Males and older adults may have a more somatic presentation of depression. Among those with physical health problems, these somatic symptoms may be confounded with symptoms of physical conditions. Not all symptoms of depression are equally useful for predicting suicide risk. The types of depression symptoms that are risk factors may vary depending on the characteristics of the sample and …
Quality Improvement Of Substance Misuse Screening Of Older Adults In Primary Care Using Evidence-Based Training, Kelly Lopez
Quality Improvement Of Substance Misuse Screening Of Older Adults In Primary Care Using Evidence-Based Training, Kelly Lopez
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background
The largest increase in preventable overdose deaths from 1999-2017 occurred among adults 50 and older, yet substance misuse among older adults is often not screened for or recognized in primary care settings. This oversight has been attributed to many factors, including age-related biases, unrecognized psychosocial and physiological differences, stigmatization, and a rapidly growing geriatric population.
Objectives
A quality improvement program using evidence-based educational training was implemented in a primary care setting with the intention to expand care knowledge and ultimately improve screening practices of older adults, especially those suffering from substance misuse.
Design
This quality improvement (QI) project used …
Perceived Effects Of Bush Burning On Agriculture And Wildlife Resources In Ghana, Caitlin A. Wilson
Perceived Effects Of Bush Burning On Agriculture And Wildlife Resources In Ghana, Caitlin A. Wilson
Graduate Theses, Dissertations, and Problem Reports (ETD)
Peace Corps was started in the 1960s by President John F. Kennedy. Ghana was one of the first established host countries that received Peace Corps Volunteers. There are five different sectors that volunteers can work in education, health, agriculture, environment, or community and economic development. Peace Corps service begins with ten weeks of pre-service training before volunteers swear in and are placed in communities throughout the country. Training covers topics such as global Peace Corps policy, health and security concerns, local language, and technical skills. I was placed in a small, rural community in the Northern Region of Ghana. My …
Structural Transformations Of Synaptic Partners During Growth And Competition Of The Giant Nerve Terminal, The Calyx Of Held, In The Medial Nucleus Of The Trapezoid Body In The Developing Postnatal Mouse, Dakota Richard Jackson
Structural Transformations Of Synaptic Partners During Growth And Competition Of The Giant Nerve Terminal, The Calyx Of Held, In The Medial Nucleus Of The Trapezoid Body In The Developing Postnatal Mouse, Dakota Richard Jackson
Graduate Theses, Dissertations, and Problem Reports (ETD)
Across many parts of the nervous system, initial neural circuit assembly involves stereotyped stages of early axonal proliferation within target territories, selective reinforcement of a subset of inputs and the removal of exuberant or unneeded connections via either activity or experience-dependent mechanisms, in a process referred to as synaptic competition. The mechanisms and associated structural transformations that underlie and define these stages of neurodevelopment have been examined in a variety of brain regions including the peripheral neuromuscular junction, the central climbing fiber innervation of cerebellar Purkinje cells and retinal ganglion cell innervation of the thalamic lateral geniculate nucleus. Each of …
Development And Implementation Of A Novel Voltage-Free Interface For Capillary Electrophoresis-Mass Spectrometry Separations Of Proteins, Courtney J. Kristoff
Development And Implementation Of A Novel Voltage-Free Interface For Capillary Electrophoresis-Mass Spectrometry Separations Of Proteins, Courtney J. Kristoff
Graduate Theses, Dissertations, and Problem Reports (ETD)
Capillary electrophoresis-mass spectrometry is a powerful technique for high-throughput and high efficiency separations combined with structural identification. Electrospray ionization is the primary interface used to couple capillary electrophoresis to mass analyzers; however, improved designs continue to be reported. A new interfacing method based on vibrating sharp-edge spray ionization is presented in this work to overcome the challenges of decoupling applied voltages and to enhance the compatibility with separations performed at near-neutral pH. The versatility and ease of use of this ionization source is demonstrated using β-blockers, peptides, and proteins. The cationic β-blocker pindolol was injected electrokinetically and detected at concentrations …