Digital Commons Network^™

A Combinatorial 5-Htr Expression Pattern Within The Ventral Projection Neurons Of The D. Melanogaster Olfactory Circuit., Mohd Freezely Ezzani Bin Mazri

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neuromodulation allows neurons within a circuit to respond to stimuli from the environment according to the correct ecological value, context, and internal state of the animal. Serotonin (5-HT) is a neuromodulator that can generate different outcomes based on its target’s serotonin receptor (5-HTR) expression by affecting secondary messenger cascades. Within the Drosophila olfactory system, ventral projections neurons (vPN) express all five insect 5-HTR that project into two olfactory processing regions, the antennal lobe (AL) and the lateral horn (LH). The significance of this 5-HTR expression is unknown. In this study, I theorized the patterns of 5-HTR expression of vPNs. I …

Face Recognition With Attention Mechanisms, Qiangchang Wang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Face recognition has been widely used in people’s daily lives due to its contactless process and high accuracy. Existing works can be divided into two categories: global and local approaches. The mainstream global approaches usually extract features on whole faces. However, global faces tend to suffer from dramatic appearance changes under the scenarios of large pose variations, heavy occlusions, and so on. On the other hand, since some local patches may remain similar, they can play an important role in such scenarios. Existing local approaches mainly rely on cropping local patches around facial landmarks and then extracting corresponding local representations. …

A Narrative Inquiry Into Veterans In Engineering, Miracle David Solley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Much research has been conducted on student veterans, in general; however, research on student veterans in engineering majors is very sparse. There is national recognition of the importance of student veterans in science, technology, engineering, and mathematics (STEM) fields as evidenced in the passage in 2020 of a bill investigating the lack of veteran students in these fields. This study adds to the literature by answering the following two research questions: What are the experiences of veteran engineering students? How has military service impacted those experiences? Twelve students and five professors from a Doctoral University: Very High Research Activity in …

Gan-Based Super-Resolution And Segmentation Of Retinal Layers In Optical Coherence Tomography Scans, Paria Jeihouni

Graduate Theses, Dissertations, and Problem Reports (ETD)

Optical Coherence Tomography (OCT) has been identified as a noninvasive and cost-effective imaging modality for identifying potential biomarkers for Alzheimer's diagnosis and progress detection. Current hypotheses indicate that retinal layer thickness, which can be assessed via OCT scans, is an efficient biomarker for identifying Alzheimer's disease. Due to factors such as speckle noise, a small target region, and unfavorable imaging conditions manual segmentation of retina layers is a challenging task. Therefore, as a reasonable first step, this study focuses on automatically segmenting retinal layers to separate them for subsequent investigations. Another important challenge commonly faced is the lack of clarity …

Charge Dynamics Of Inas Quantum Dots Under Resonant And Above-Band Excitation, Gary R. Lander Jr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Research involving light-matter interactions in semiconductor nanostructures has been an interesting topic of investigation for decades. Many systems have been studied for not only probing fundamental physics of the solid state, but also for direct development of technological advancements. Research regarding self-assembled, epitaxially grown quantum dots (QDs) has proven to be prominent in both regards. The development of a reliable, robust source for the production of quantum bits to be utilized in quantum information protocols is a leading venture in the world of condensed matter and solid-state physics. Fluorescence from resonantly driven QDs is a promising candidate for the production …

Food Safety In The Us: Regulation, Liability, And Tracing, Marziyeh Bahalou Horeh

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation addresses three issues related to food safety. First, it examines the economic efficiency of irrigation water quality guidelines of Food Safety Modernization Act. Second, it estimates the value of traceability in the U.S. lettuce supply chain. Third, it uses state-level data and panel regression models to examine the relationship between product liability laws and reported foodborne illnesses in the U.S.

The second chapter develops a theoretical framework and a corresponding empirical analysis to analyze the Food and Drug Administration's irrigation water quality regulatory standard pursuant to the Food Safety Modernization Act. We develop a stochastic, price endogenous partial …

Integrated Large Discontinuity Factor, Lamodel And Stability Mapping Approach For Stone Mine Pillar Stability, Mustafa Baris Ates

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this research is to develop a software tool that integrates the large discontinuity factor (LDF) and the Boundary Element Method software (BEM), LaModel, to allow stone mine operators to assess the impact of the large discontinuities on local pillar stability. National Institute for Occupational Safety and Health (NIOSH) published design guidelines for underground stone mines to guide the industry in designing pillar and roof support. These guidelines emphasize the impact of large, angular discontinuities on pillar strength. Esterhuizen et al. (2011) derived the large discontinuity factor (LDF) to account for the impact of discontinuities on pillar stability …

The Process And Case Study Approach To Implementing A Nutrition-Specific Dissemination And Implementation Science Training In Appalachia, Ayron E. Walker

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Nutrition professionals face implementation challenges due to their lack of knowledge to incorporate D&I science into intervention design. To improve intervention outcomes, nutrition professionals must be trained in D&I science, which are currently absent in the field.

Aims: To identify and assess nutrition educators and practitioners perceived motivations, self-efficacy, and attitudes in using D&I science to inform the educational design and strategies of a nutrition-specific D&I curriculum for nutrition educators. Then to test feasibility of the nutrition-specific curriculum in increasing knowledge, self-efficacy, and attitudes by a case study approach, pre/post intervention design.

Methods: First, scoping review methodology involved the …

“I Lost Everything I Owned… Now I’M Growing That Back”: Narratives Of Redemption After Meth Immersed Lives, Danielle M. Stoneberg

Graduate Theses, Dissertations, and Problem Reports (ETD)

There is a lack of knowledge on how the process of desisting (i.e., maintaining abstinence) works for those leaving immersed drug lifestyles, leaving a need for a better understanding of the role and impact of identity in drug desistance. Through secondary analysis of interview data from a sample of 33 former methamphetamine manufacturers, this study examines the applicability of Maruna’s (2001) redemption narrative framework and identifies other aspects featured in their narratives that signaled identity change. Results found all participants discussed at least one component of the framework in their interviews. Their narrative identities changed over time to recognize that …

Human Welfare & Emergencies: Education, Natality, And Violence, Erika Antolin Davies

Graduate Theses, Dissertations, and Problem Reports (ETD)

I identify changes in human action during emergencies such as heavy precipitation and shelter-in-place orders. In two chapters I explore the effects of precipitation on educational attainment and birth rates as residential broadband access increases. In my third chapter I identify the movement of pets in and out of the home as a trigger for domestic violence during the COVID-19 lockdown. I estimate difference-in-difference regressions with panel data, coming to three conclusions. First: educational attainment in Appalachia is stunted by precipitation, as students have difficulty getting to school in bad weather. As this historically under-educated region of the US gains …

Top-Down & Bottom-Up Approaches To Robot Design, Dylan Michael Covell

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis presents a study of different engineering design methodologies and demonstrates their effectiveness and limitations in actual robot designs. Some of these methods were blended together with focus on providing an easily interpreted project design flow while implementing more bottom-up, or feedback, elements into the design methodology. Typically design methods are learned through experience, and design taught in academia aims to shape and formalize previous experience. Usually, inexperienced engineers are taught approaches resembling the Verein Deutscher Ingenieure (VDI) 2221 process. This method presented by the Association of German Engineers in 2006 is regarded as the general system design process. …

On Generalizations Of Supereulerian Graphs, Sulin Song

Graduate Theses, Dissertations, and Problem Reports (ETD)

A graph is supereulerian if it has a spanning closed trail. Pulleyblank in 1979 showed that determining whether a graph is supereulerian, even when restricted to planar graphs, is NP-complete. Let $\kappa'(G)$ and $\delta(G)$ be the edge-connectivity and the minimum degree of a graph $G$, respectively. For integers $s \ge 0$ and $t \ge 0$, a graph $G$ is $(s,t)$-supereulerian if for any disjoint edge sets $X, Y \subseteq E(G)$ with $|X|\le s$ and $|Y|\le t$, $G$ has a spanning closed trail that contains $X$ and avoids $Y$. This dissertation is devoted to providing some results on $(s,t)$-supereulerian graphs and …

Navigating Abrupt Shifts In Contextual Discourses During A Pandemic And Lack Of Mentorship: A Preservice Teacher’S Journey Developing Critical Pedagogical Discourses, Casey L. King

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study is centered on one English language arts (ELA) preservice teacher’s development of her critical pedagogical discourses (CPD) with the contextual discourses of a school placement for preservice teaching and later shift to a full-time teacher before the placement was complete during a pandemic and in the midst of implementing online learning. Data is drawn from a 4-month interpretive qualitative case study that included classroom observations and semi-structured interviews. The objective for this study included how a preservice teacher uses their beliefs and identity about instruction amid changing contextual discourses in a pandemic and with a lack of mentorship. …

Multisided Quality Inspection In Smart Manufacturing Systems, Milica Babic

Graduate Theses, Dissertations, and Problem Reports (ETD)

As technology advances so does its adoption in industry and our everyday lives. We use technology to better our daily tasks whether at home or in the workplace. In the workplace there are many benefits of implementing new technologies to improve processes and products while at the same time being cautious about associated costs. Costs associated with incorporating new digital technologies include but are not limited to hardware and software, system integration, testing, and employee training. Now that we have entered the era of the Fourth Industrial Revolution, there are many opportunities for improvements in manufacturing that involve Smart Digital …

Associations Between Self-Reported Awe And Heart Rate, Laura E. Bernstein

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fredrickson’s (1998, 2013) broaden and build theory states that positive emotions can expand our social and cognitive awareness and provide health benefits. Some positive emotions, such as awe, may operate differently. We sought to understand how subjective reports of awe, induced through videos, correlate with HR. We know that HR tends to decrease with age (Umetani et al., 1998), individuals have less physiological reactivity as they age (Blanchard-Fields, 2007), and older adults report more positive emotions than negative emotions (Mroczek & Kolarz, 1998). Given these findings, we were interested in understanding whether there were age differences in self-reported awe and …

Examining Evolutionary Rate In Xiphosura, Samantha B. Ocon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Horseshoe crabs, a group of aquatic chelicerate arthropods of the class Xiphosura, are strongly linked with the concept of “living fossils” – a term colloquially used to refer to clades that display a consistently low rate of morphological evolution through time. The concept of living fossils has been hotly debated, as it is considered to simplify or obscure millennia of evolutionary change. Recent methodological and computational advances in the paleobiological sciences have allowed for the investigation of these claims. Xiphosura are a model taxon for this type of investigative study because they exhibit a complex evolutionary history, despite their reputation …

Discussing Changes In Historical Human–Environmental Dynamics Through Ecosystem Services Interactions And Future Scenarios In A Rural-Mining Region Of Central Appalachians, Vincenzo Cribari

Graduate Theses, Dissertations, and Problem Reports (ETD)

The aim of this dissertation was to investigate how recent processes of land-change induced by humans contributed to the shaping and alteration of the current landscape in a headwater system of Central Appalachians in West Virginia (US), to understand the interactions and tradeoffs among ecosystems services and address potential solutions for targeting more sustainable human-environment interactions in a region that is deeply grounded on extractive economies. The multitiered objective was addressed through different research phases in order to unfold and disentangle a series of complex problems that the study area presents. Three main phases were used; they corresponded to distinct …

Deep Radio Observations And The Role Of The Cosmic Web In Galaxy Evolution, Nicholas M. Luber

Graduate Theses, Dissertations, and Problem Reports (ETD)

A current open question in the evolution of galaxies, is what are the physical mechanisms that cut off galaxies from their primordial gas reservoirs, resulting in the end of their star-formation capabilities? Recent observational programs have shown that the properties of galaxies show dependencies on their placement within the large-scale structure (LSS) of the universe. These observations have motivated recent developments in theoretical work that have shown how a galaxy's interaction with the LSS may impact its connection to primordial gas supply, and ability to continue to accrete gas, the fundamental ingredient in star-formation.

In order to investigate the role …

Freeze! The Impact Of A Guided Imagery Intervention On Looming Vulnerability And Subclinical Contamination-Ocd Symptoms, Amber Lynn Billingsley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Looming vulnerability (LV) refers to the tendency to appraise and perceive potential threats as dynamic and increasing in risk. Research suggests that contamination-fearful individuals may have an increased tendency to interpret contamination as growing or spreading (i.e., “looming”), which may hinder habituation to contamination and play a role in the maintenance of contamination-OCD symptoms. Studies have shown that engaging in imagery in which one mentally freezes contamination in place decreases state levels of fear, though little is known about its longer-term effects (e.g., after one week). The present study aimed to experimentally manipulate LV using freeze imagery in a subclinical …

Evaluating Dro With Asymmetrical Magnitude Of Reinforcement, Lindsey M. Hronek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Differential reinforcement of other behavior (DRO) is a reinforcement schedule used in behavior analytic procedures aimed at decreasing various forms of challenging behavior. DRO commonly includes a reinforcement component and an extinction component; a reinforcer is delivered on an interval-based schedule dependent on the omission of a target behavior and the reinforcer is withheld following the occurrence of the target behavior (i.e., extinction). Although interventions using DRO can be effective for challenging behavior, procedures that include extinction can at times be impractical or lead to undesirable side effects. A DRO schedule can be implemented without extinction, but previous research has …

Transitions Between The Steps Of Group Iic Intron Forward And Reverse Splicing And Integration Into Dna, Claire Mae Smathers

Graduate Theses, Dissertations, and Problem Reports (ETD)

Group II introns are ancient ribozymes capable of self-excision and mobility into new genomic locations. As the ancestors of both the eukaryotic spliceosome and eukaryotic retroelements, these simple RNA machines serve as excellent models for understanding the mechanisms of both gene splicing and retroelement activity in eukaryotes. Although group II introns have been studied for decades, knowledge of the most unique and arguably evolutionarily relevant class of group II introns, IIC, is limited. Our knowledge is especially limited in terms of understanding how IIC introns mediate the transition between the two transesterification steps of forward splicing and reverse splicing into …

Behaviors, Contextual Influences, And Consequences: Relationships That Affect Student Decision-Making Of Academic Misconduct In College, Justine A L Burnett

Graduate Theses, Dissertations, and Problem Reports (ETD)

Academic misconduct on college campuses is not a new challenge for higher education institutions but an old problem that has changed considerably. Student demonstrations of academic misconduct behaviors have evolved, making it difficult for institutions to consistently keep well-informed on how students cheat to effectively respond to violations of academic integrity policies. This study investigates the relationships between misbehaviors, their associated consequences, and influences to prevent, respond to, and reduce academic misconduct at a large research-intensive university.

This quantitative study uses institutional academic misconduct reports between 2017 and 2020 and student surveys to examine significant relationships in the decision-making process …

Targeting Vulnerabilities In Cell State And Calcium Signaling For The Treatment Of Lung Cancer, Clark Jones

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lung cancer remains the deadliest of all cancers due to the high mutational burden associated with the disease. Combating mutational drivers and drug resistance proves to be essential in the development of novel therapies to improve patient outcomes. A first-in-class cyclic peptide known as MTI-101 has been shown to induce necrotic cell death in a caspase independent manner. MTI-101 was derived from the linear peptide known as HYD1 that was found in a high throughput screen to block cell adhesion with the extracellular matrix. The compound was further optimized and cyclized to the currently used MTI-101 that was found to …

A Monte Carlo Simulation Of Rat Choice Behavior With Interdependent Outcomes, Michelle A. Frankot

Graduate Theses, Dissertations, and Problem Reports (ETD)

Preclinical behavioral neuroscience often uses choice paradigms to capture psychiatric symptoms. In particular, the subfield of operant research produces nested datasets with many discrete choices in a session. The standard analytic practice is to aggregate choice into a continuous variable and analyze using ANOVA or linear regression. However, choice data often have multiple interdependent outcomes of interest, violating an assumption of general linear models. The aim of the current study was to quantify the accuracy of linear mixed-effects regression (LMER) for analyzing data from a 4-choice operant task called the Rodent Gambling Task (RGT), which measures decision-making in the context …

Analysis Of Forensically Relevant Evidence Using Electrochemistry, Spectroscopy, And Mass Spectrometry Tools, Colby Edward Ott

Graduate Theses, Dissertations, and Problem Reports (ETD)

Forensic science relies on the use of multiple techniques in the assessment of evidence to increase the accuracy and reliability of the results. However, with the rapidly changing drug landscape due to the introduction of novel psychoactive substances, many traditional screening methods are no longer sensitive or selective enough for use. Additionally, many screening methods such as chemical color tests are prone to false positive and negative results and are subjective. Therefore, the goal of this dissertation was to develop a novel analytical scheme that can provide a more efficient, rapid, and sensitive method that will facilitate adoption in the …

The Discover Model: A Prescriptive Method For Instructional Tool Selection And Use In Seeking To Boost Instructor Immediacy And Social Presence In Online Courses, Lee O. Silverman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Higher education faculty who teach online can face numerous challenges in providing optimal experiences for their students. Besides their potentially limited instructional design expertise and understanding of how to optimize technology to support learning, faculty may have difficulties in finding ways to make themselves be perceived as real people who are approachable, caring, and likeable due to online nature of the learning context. As a preliminary means to address these issues, the current study focused on the development of the DISCOVER Model, which was designed to provide higher education faculty with a framework to develop actionable plans in the creation …

Reinforcement Learning For Process Control: Applications To Energy Systems, Elijah Ballard Hedrick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Reinforcement learning (RL) is a machine learning method that has recently seen significant research activity owing to its successes in the areas of robotics and gameplaying (Silver et al., 2017). However, significant challenges exist in the extension of these control methods to process control problems, where state and input signals are nearly always continuous and more stringent performance guarantees are required. The goal of this work is to explore ways that modern RL algorithms can be adapted to handle process control problems; avenues for this work include using RL with existing controllers such as model predictive control (MPC) and adapting …

Investigating The Mitochondrial Protein Mitoneet In C. Elegans Models Of Aging And Alzheimer's Disease, Jacob Ryan Boos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Oxidative stress is an imbalance between reactive oxygen species production and elimination, favoring the former. Reactive oxygen species serve as important signaling molecules for physiological homeostasis. However, when produced in excess, these once important signaling molecules become detrimental, disrupting cellular functions, and ultimately leading to cell death. In aging, reactive oxygen species production is increased, accompanied with reductions in oxidative stress resistance, increasing the risk for developing age-related diseases including cardiovascular disease, cancer, stroke, and neurodegenerative diseases. The outer mitochondrial membrane iron-sulfur cluster containing protein mitoNEET (CISD1; gene CISD1) has shown to be a mediator of mitochondrial function and …

Performance Of Peltier Cooled Technology During Preconcentration Of Volatile Organic Compounds Analyzed By Gas Chromatography-Mass Spectrometry (Gc-Ms) Using Niosh Manual Of Analytical Methods (Nmam) 3900, Elizabeth Ann Fernandez

Graduate Theses, Dissertations, and Problem Reports (ETD)

Using evacuated canisters for whole-air sampling allows for sampling without specific knowledge of the environment and potential analytes. Evacuated canisters are able to tolerate concentrations ranging from parts per trillion (PPT) to parts per million (PPM). The U.S. Environmental Protection Agency (EPA) has used evacuated canisters for years to sample volatile organic compounds (VOCs) from ambient air using their method TO-15 (LeBouf, et al., 2019). The GC-MS system used for the development of NMAM 3900 used liquid nitrogen to cool sorbent traps in the preconcentrator. Liquid nitrogen allows for cooling of specified points below ambient temperature. An alternative to liquid …

Repercussions: The Pressure To Be Thin, Shuhan Liu

Graduate Theses, Dissertations, and Problem Reports (ETD)

My MFA thesis and supporting exhibition will highlight ceramics work I have created with the intention of dissecting the relationship between a soul and reality to convey the story of tension and anxiety and show it in a way that would let viewers identify with my discomfort and anxiety. The inspiration for my work came from the severe body anxiety that I faced that broke out during the three years of psychological stress caused by the pandemic. Using personal narratives as a starting point, I created object-based artwork that addresses the external pressures I feel to be skinny. As an …