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Augmentation And Hybridization Of Conventional Forms Of Process Control With Advanced Control Methods, Daniel Paul Beahr
Augmentation And Hybridization Of Conventional Forms Of Process Control With Advanced Control Methods, Daniel Paul Beahr
Graduate Theses, Dissertations, and Problem Reports (ETD)
Within the last decade in the field of process control, there has developed a distinct gap between the technological advancements of today and the well-established theory that has preceded it. This is most evident where the novel developments and structures often outpace the necessary guarantees and strong foundation required to ensure the possibility of widespread adoption. Therefore, the goals of this work are to broadly integrate those novel advanced control methods into the field of process control in such a way to increase the applicability and encourage implementation.
The first portion of this work seeks to further explore the nature …
The Abuse Liability Of Oral Nicotine Pouches In Electronic Cigarette Users, Jakob D. Bohland
The Abuse Liability Of Oral Nicotine Pouches In Electronic Cigarette Users, Jakob D. Bohland
Graduate Theses, Dissertations, and Problem Reports (ETD)
Oral nicotine pouches (ONPs) are products containing synthetic or tobacco derived nicotine in a cellulose pouch. While relatively novel in their current state, ONPs are increasing in popularity, with little known about their national level prevalence. Extant work has suggested that electronic cigarette (e-cig) users may be interested in ONPs; however, no abuse liability studies have been conducted comparing ONPs directly to e-cigs. In the few abuse liability studies that have been conducted, ONPs have been evaluated in comparison to combustible cigarettes or smokeless tobacco (SLT). These studies suggest ONPs may be less reinforcing than combustible cigarettes or SLT. Therefore, …
Commissioning And Recording Project Of New Works For Saxophone Focused On Promoting Mexican Composers And Educating Future Commissioning Saxophonists, Andres Efrain Santana
Commissioning And Recording Project Of New Works For Saxophone Focused On Promoting Mexican Composers And Educating Future Commissioning Saxophonists, Andres Efrain Santana
Graduate Theses, Dissertations, and Problem Reports (ETD)
This document chronicles my process of commissioning and recording five new works by Mexican composers. To contextualize this experience, I provide a brief introduction of Mexican contemporary music history, an overview of second-hand accounts of the commissioning process, my personal experience of this process, and my assessment of the impact these works could have on the classical saxophone repertoire. As I have reflected on my own experience with historical and contemporary accounts of the commissioning process, it has become clear that personal connections between composers and performers and the patronage or funding linked to those relationships are just as important …
Development Of Fast And Comprehensive Approaches For Gunshot Residue Interpretation Using Ambient Ionization, Mass Spectrometry, And Microparticle Sampling Studies, Thomas Dimmey Ledergerber
Development Of Fast And Comprehensive Approaches For Gunshot Residue Interpretation Using Ambient Ionization, Mass Spectrometry, And Microparticle Sampling Studies, Thomas Dimmey Ledergerber
Graduate Theses, Dissertations, and Problem Reports (ETD)
The information derived from the forensic examination of gunshot residue (GSR) can be critical during the investigative and trial stages in the criminal justice system. However, the complexity of the GSR deposition, transfer, and persistence mechanisms calls for meticulous handling and identification processes. Novel advances in evidence interpretation and analysis via instrumental methods are current areas of growing interest that must be pushed along the chain from research to practice in a timely manner. Therefore, this research focuses on developing both rapid and comprehensive methods for detecting gunshot residue evidence and effectively communicating its significance to the investigators or trier …
Extending Effects Of The Good Behavior Game With Mixed Schedules, Amina Boukhris
Extending Effects Of The Good Behavior Game With Mixed Schedules, Amina Boukhris
Graduate Theses, Dissertations, and Problem Reports (ETD)
Student disruptive behavior in the classroom can adversely affect both students and teachers. The Good Behavior Game (GBG) is a well-established classroom management strategy used to reduce disruption. However, its use remains limited due to implementation barriers reported by teachers, such as effort associated with delivering feedback, and the limited generalization of the GBG effects to times when the game is not in place. The current study had two main objectives: (a) to evaluate whether a modified version of the GBG implemented on a mixed-schedule-like arrangement (MIX GBG) could reduce student disruption as effectively as the standard version (MULT GBG), …
Identifying Factors Associated With Time To Diagnosis For Symptomatic Intestinal Malrotation In Pediatric Patients, Katie E. Corcoran
Identifying Factors Associated With Time To Diagnosis For Symptomatic Intestinal Malrotation In Pediatric Patients, Katie E. Corcoran
Graduate Theses, Dissertations, and Problem Reports (ETD)
Intestinal malrotation is a rare condition in which the intestines rotate improperly during embryonic development. Intestinal malrotation is typically diagnosed in pediatric patients with an upper gastrointestinal imaging (UGI) series. Longer time to diagnosis of intestinal malrotation increases the risk of mortality and severe morbidity. While the need for timely diagnosis is well-established in the literature, the correlates of time to diagnosis are largely unknown. The classic medical presentation for intestinal malrotation is an infant presenting with green bilious emesis. I hypothesize that time to diagnosis of intestinal malrotation will be longer in symptomatic pediatric patients when they present differently …
La2nio4+Δ-Based Solid Oxide Electrolysis Cell (Soecs) Electrodes Enhanced With Complex Perovskite Nanocatalyst Processed By Surfactant-Enabled Infiltration, Cole Samuel Klemstine
La2nio4+Δ-Based Solid Oxide Electrolysis Cell (Soecs) Electrodes Enhanced With Complex Perovskite Nanocatalyst Processed By Surfactant-Enabled Infiltration, Cole Samuel Klemstine
Graduate Theses, Dissertations, and Problem Reports (ETD)
As the world seeks to reduce its reliance on hydrocarbons, the demand for sustainable hydrogen production methods has become increasingly critical. Hydrogen is a versatile energy carrier that can be produced from various sources, including water, natural gas, and biomass. Replacing the burning of hydrocarbons with hydrogen could significantly reduce greenhouse gas emissions, contributing to global climate goals like those set by the US H2NEW program. The joint technologies of solid oxide fuel and electrolysis cells present the ability to both produce and process clean hydrogen to meet these goals. Development into solid oxide fuel cells has been met with …
Resilience In Adolescents With Type 1 Diabetes: The Relation Between Grit, Benefit-Finding, Diabetes Distress, Hba1c And Health-Related Quality Of Life, Hannah Hardiman
Resilience In Adolescents With Type 1 Diabetes: The Relation Between Grit, Benefit-Finding, Diabetes Distress, Hba1c And Health-Related Quality Of Life, Hannah Hardiman
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background: Type 1 diabetes (T1D) is a common pediatric chronic illness that requires complicated management by both the child and their caregiver. Research and clinical guidelines have highlighted adherence (as measured by HbA1c) and health-related quality of life (HRQOL) as important outcomes particularly in adolescents with T1D. Notably, diabetes distress has been identified as a risk factor contributing to poor adherence and HRQOL outcomes in this population. Given these considerations, understanding what resilience factors contribute to optimal outcomes is vitally important to inform future interventions. Grit and benefit-finding are two novel resilience factors that have yet to be fully evaluated …
Developing Consensus-Based Methods For The Examination And Interpretation Of Contemporary Vehicle, Architectural, And Portable Electronic Device Glasses By Micro-X-Ray Fluorescence Spectrometry, Zachary Bailey Andrews
Developing Consensus-Based Methods For The Examination And Interpretation Of Contemporary Vehicle, Architectural, And Portable Electronic Device Glasses By Micro-X-Ray Fluorescence Spectrometry, Zachary Bailey Andrews
Graduate Theses, Dissertations, and Problem Reports (ETD)
Glass is a trace material that is commonly encountered during investigations of violent crimes. When glass is recovered at crime scenes, it can be used to establish links between suspects, victims, and the scene itself. The most discriminatory form of analysis for glass evidence is elemental analysis, and micro-X-ray fluorescence spectrometry (µXRF) is becoming an increasingly common technique used for this purpose. Recent advances in µXRF technology, such as the introduction of silicon drift detectors (SDD) and improved polycapillary optics are promising in enhancing the capabilities for the examination of glass evidence in forensic investigations. However, along with these advances …
Increasing Preparedness For Malignant Hyperthermia Crises: An Evidence Based Quality Improvement Project, Elise Jozwiak
Increasing Preparedness For Malignant Hyperthermia Crises: An Evidence Based Quality Improvement Project, Elise Jozwiak
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction/Background: MH is a low frequency, but high risk potentially fatal genetic mutation if left untreated. A rural Pennsylvania Hospital was found to have an incidence rate of 12/4,033 MH related occurrences within the last 6 months. Delayed treatment of MH can result in increased mortality rates and poor patient outcomes.
Purpose: Given the rarity and high mortality rate without prompt treatment, implementation of a standardized cognitive aid to be kept on the Malignant Hyperthermia (MH) cart, coupled with operating room staff education on early recognition and treatment of malignant hyperthermia can assist in proper perioperative MH management steps for …
Does Education On Aseptic Non-Touch Technique Affect Nurse Knowledge On Aseptic Technique When Placing Ultrasound Guided Peripheral Intravenous Lines? A Quality Improvement Initiative, Hannah G. Keyser
Graduate Theses, Dissertations, and Problem Reports (ETD)
This Doctor of Nursing Practice (DNP) project attempted to increase nurse’s knowledge of aseptic technique when placing USG-PIVs in hospitalized adult patients after educational training on the Aseptic Non-Touch Technique Clinical Practice Framework (ANTT CPF). Implementation of the ANTT CPF in the cardiovascular intensive care unit (CVICU) at Ruby Memorial Hospital, as a didactic educational session for nurses already trained to place ultrasound-guided peripheral intravenous lines, was utilized for this DNP project. Pre- and post-surveys were employed to determine changes in knowledge scores as well as feelings of comfort and knowledge related to the CPF. Results remained stable for survey …
Nephrocheck Implementation And Its Impact On The Incidence Of Acute Kidney Injury After Coronary Artery Bypass Graft Surgery, Michael Maccourtney
Nephrocheck Implementation And Its Impact On The Incidence Of Acute Kidney Injury After Coronary Artery Bypass Graft Surgery, Michael Maccourtney
Graduate Theses, Dissertations, and Problem Reports (ETD)
Abstract
NephroCheck Implementation and its Impact on the Incidence of Acute Kidney Injury After Coronary Artery Bypass Graft Surgery
Michael C. MacCourtney
Problem Statement: Acute kidney injury occurs in up to 50% of patients after cardiac surgery (Meersche et al., 2017). This contributes to significant morbidity, mortality, and costs (Helgadottir et al., 2016). At the time of the project implementation, the standard of care involved measuring renal function utilizing serum creatinine (SCr) and urine output (UOP) without NephroCheck. These renal function labs do not represent a timely and accurate assessment of the patient’s current renal status because they do not …
Effects Of High-Frequency Repetitive Transcranial Magnetic Stimulation On Impulse Control Disorders In Patients With Parkinson’S Disease On Dopamine Replacement Therapy, Katherine Muksuris
Effects Of High-Frequency Repetitive Transcranial Magnetic Stimulation On Impulse Control Disorders In Patients With Parkinson’S Disease On Dopamine Replacement Therapy, Katherine Muksuris
Graduate Theses, Dissertations, and Problem Reports (ETD)
Parkinson’s Disease (PD) is a debilitating neurodegenerative disorder that causes motor deficits, cognitive impairment, and depression. The mainstay treatment for motor symptoms is dopamine replacement therapy (DRT). DRT takes the form of levodopa or dopamine receptor agonists (DAs) and can be associated with impulse control disorders (ICDs). Currently, the approach to mitigating these side effects is to decrease or stop DRT, which may cause motor symptoms to return, making the management of the disorder more difficult. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation treatment for multiple disorders, including its approved use for smoking cessation. It has also shown …
Modeling Energetic Electron Precipitation: Radiation Belt Loss, Its Drivers, And Atmospheric Impacts, Zhi Gu Li
Modeling Energetic Electron Precipitation: Radiation Belt Loss, Its Drivers, And Atmospheric Impacts, Zhi Gu Li
Graduate Theses, Dissertations, and Problem Reports (ETD)
Energetic electrons in the terrestrial outer radiation belt present significant hazards to spacecraft systems and human operations in space. The intensity of these electrons can vary rapidly and dramatically during geomagnetic storms, governed by a complex competition between acceleration and loss processes. Among these, precipitation into the atmosphere via resonant wave-particle interaction acts as a key loss mechanism. This dissertation focuses on improving the quantification of energetic electron precipitation using physics-based modeling constrained by low-altitude satellite observations.
We begin by developing and validating the Drift-Diffusion model, which simulates low-altitude electron dynamics while accounting for azimuthal drift, pitch-angle diffusion, and atmospheric …
Computational Approaches For Diagnosing Neurological Impairments And Restoring Functional Movement, Serhii Bahdasariants
Computational Approaches For Diagnosing Neurological Impairments And Restoring Functional Movement, Serhii Bahdasariants
Graduate Theses, Dissertations, and Problem Reports (ETD)
Movement is the primary means by which the nervous system converts intention into interaction with the environment. Voluntary limb motion enables standing, walking, reaching, and grasping—actions that underpin self‑care, communication, and economic participation. When diseases or injuries disrupt the pathways that couple neural commands to muscle forces—whether through cortical stroke, spinal cord injury, or peripheral nerve damage—mechanical outcomes such as weakness, loss of coordination, and ultimately reduced mobility emerge. These impairments cascade into secondary complications, increased dependence on caregivers, and diminished quality of life. Quantifying how the lesion alters the mechanics of movement is therefore essential for designing targeted interventions …
Soft Epilogue, Chloe C. Firth
Soft Epilogue, Chloe C. Firth
Graduate Theses, Dissertations, and Problem Reports (ETD)
This written document is the accompanying thesis for my Master of Fine Arts Exhibition, Soft Epilogue. The work in the exhibition serves as a visual record of my eating disorder recovery process. Each piece in the exhibition addresses a selected writing prompt from the book 8 Keys to Recovery from an Eating Disorder, published in 2011 and written by therapists and former eating disorder patients Carolyn Costin and Gwen Schubert Grabb. The book provides information and journal assignments regarding the development of eating disorders, how to maintain the motivation to recover, and how to navigate the complicated emotions …
Customer Segmentation And Fuel Economy Prediction Using Telemetry Data From Heavy-Duty Trucks, Batishahe Selimi
Customer Segmentation And Fuel Economy Prediction Using Telemetry Data From Heavy-Duty Trucks, Batishahe Selimi
Graduate Theses, Dissertations, and Problem Reports (ETD)
Heavy-duty trucks constitute only a modest fraction of on-road vehicles, yet their intensive duty cycles and high fuel demands yield a disproportionately large share of transportation fuel use and greenhouse gas emissions. Addressing this imbalance requires data-driven tools that capture the realities of fleet operation and translate complex telemetry into actionable insight.
This dissertation introduces a unified machine-learning framework that operates exclusively on high resolution time-series data collected from fifty-nine diesel trucks deployed across Southern California. It begins by constructing a multi-modal feature space that blends statistical summaries of key engine signals, static vehicle descriptors, and Mel-Frequency Cepstral Coefficients, thereby …
The Economics Of Crime And Reform: Essays On Alcohol Taxation, Cannabis Legalization, And Felon Enfranchisement., Georgios Marios Bantis
The Economics Of Crime And Reform: Essays On Alcohol Taxation, Cannabis Legalization, And Felon Enfranchisement., Georgios Marios Bantis
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation comprises three independent yet thematically connected essays that explore the effects of public policy on crime and municipal finance. The first chapter examines the relationship between alcohol taxation and crime, assessing how changes in excise tax policies influence criminal activity. The second chapter investigates the fiscal implications of felon enfranchisement, analyzing how the restoration of voting rights to individuals with felony convictions affects municipal public finance. The third chapter evaluates the impact of cannabis legalization on crime, focusing on whether and how legalization alters crime patterns. Each chapter is structured as a stand-alone research paper. A general introduction …
Long-Term Trends In Brook Trout Production And Large Wood In West Virginia Headwater Streams, Halden D. Edwards
Long-Term Trends In Brook Trout Production And Large Wood In West Virginia Headwater Streams, Halden D. Edwards
Graduate Theses, Dissertations, and Problem Reports (ETD)
Projects which monitor long-term trends in ecosystems are uncommon but extremely important in the management of fish and wildlife populations. By assessing the health of a population or community over multiple temporal scales, these projects provide true insight into population success that cannot be elucidated through short-term studies. Long-term projects are also instrumental in assessing the effects of disturbance events as they provide valuable baseline information which can be compared to data collected post-disturbance. Even more importantly, long-term studies can help identify crucial changes in the health and success of imperiled and invaluable species to improve and focus conservation efforts. …
Artificial Intelligence Approaches For Membrane Fouling Prediction, Yazhou Jiang
Artificial Intelligence Approaches For Membrane Fouling Prediction, Yazhou Jiang
Graduate Theses, Dissertations, and Problem Reports (ETD)
Abstract
Membrane fouling is a persistent and critical challenge in membrane-based separation processes, resulting in reduced performance, higher energy consumption, and increased operational and maintenance costs. Addressing this issue is essential for improving the long-term sustainability and efficiency of membrane systems. This report provides a comprehensive overview of membrane fouling mechanisms—such as organic, inorganic, particulate, and biofouling—and explores the growing role of Artificial Intelligence (AI) in tackling this problem. Specifically, it reviews three widely adopted AI techniques: Artificial Neural Networks (ANN), Fuzzy Logic (FL), and Support Vector Machines (SVM). Each method is examined through a series of literature-based case studies, …
Finite Element Modeling And Experimental Characterization Of Overmolded Gold-Palladium Composite Leads And Their Mechanical Behavior Under Cyclic Fatigue For Long-Term Implant Applications, Tanner Davis
Graduate Theses, Dissertations, and Problem Reports (ETD)
Auditory Nerve Interface (ANI) devices, currently in developmental stages, represent an emerging neuroprosthetic approach to restore hearing in severe sensorineural loss patients by directly stimulating the auditory nerve via the Utah Slanted Electrode Array (USEA). Conventional implant leads are comprised of multiple wires made from materials such as platinum-iridium and MP35N stainless steel that are overmolded in an insulative material. These materials are not possible to bond with to electrode array used in the ANI device, necessitating the evaluation of a new material like Au-Pd to ensure its functionality and durability under cyclic stresses. This gap necessitates characterization of alternative …
Reactive Model-Free Control For Underactuated Vehicles Operating In Resource-Constrained Environments, Austin Lane Sponaugle
Reactive Model-Free Control For Underactuated Vehicles Operating In Resource-Constrained Environments, Austin Lane Sponaugle
Graduate Theses, Dissertations, and Problem Reports (ETD)
Buoyancy-driven, underactuated vehicles offer a compelling solution for long-duration autonomous operations in constrained environments. By leveraging buoyancy to generate lift, these vehicles can remain aloft for extended periods with minimal power requirements, making them well-suited for applications in atmospheric monitoring, planetary exploration, and communications. However, their limited actuation authority, strong coupling with environmental forces, and operating domains introduce significant control challenges, including nonlinearity, sensitivity to external disturbances, and limited observability.
This work investigates the design and implementation of lightweight, reactive model-free control strategies that enable robust autonomy in such constrained settings. A digital Extremum Seeking Controller (ESC) is first implemented …
Molecular Characterization Of Fungus-Arthropod Associations, Angie M. Martin
Molecular Characterization Of Fungus-Arthropod Associations, Angie M. Martin
Graduate Theses, Dissertations, and Problem Reports (ETD)
Arthropods, or phylum Arthropoda, are the largest group of animals, accounting for over three quarters of all animal records on NCBI Taxonomy. And yet, only 40% of all deposited sequences on NCBI Nucleotide come from arthropods. Clearly, arthropods are an understudied group of animals: they are small, often drab, and lead lives very alien to our own. Arthropods have chitinous exoskeletons, segmented bodies, and jointed appendages, and include crabs, barnacles, insects, spiders, and millipedes. Since the era of DNA based studies took off in the 1980s, DNA and other small molecules have been integral to our understanding of the Earth …
A Quality Improvement Initiative To Decrease Sugammadex Expenditures, Jordan Austin Gardo
A Quality Improvement Initiative To Decrease Sugammadex Expenditures, Jordan Austin Gardo
Graduate Theses, Dissertations, and Problem Reports (ETD)
Abstract
A Quality Improvement Initiative to Decrease Sugammadex Expenditures
Jordan Gardo
Introduction/Background: The manufacturer’s suggestion in the dosing of the Sugammadex is
generally dosed at 2-4 mg/kg of total body weight (TBW) depending on the extent of
neuromuscular blockade. Evidence suggests that in the morbidly obese population, this
can lead to excessive dosing due to the drug's hydrophilic properties, making it less cost-
effective. Dosing based on adjusted body weight (ABW) leads to dose reductions while
achieving full reversal of neuromuscular blockade as measured by quantitative train-of-
four monitoring, resulting in lower costs from decreased vial usage.
Purpose: The purpose …
Comparative Analysis Of Electrode Encapsulation Reliability: Planar Vs. Thermoformed Interdigitated Neural Electrodes In Biomedical Engineering, Tatum Peyerl
Graduate Theses, Dissertations, and Problem Reports (ETD)
Durable dielectric encapsulation is crucial for the long-term function of implantable neural electrodes; however, the reliability of curved, thermoformed coatings remains underexplored. This study addresses that gap by comparing planar (non-thermoformed) and thermoformed interdigitated neural electrodes (IDEs) encapsulated in Polyimide-2611. Both device types underwent accelerated in vitro aging in phosphate‑buffered saline (PBS) at 67 °C for approximately 91 days, simulating two years of physiological exposure. Post-accelerated aging evaluation included electrochemical impedance spectroscopy (EIS) from 0.1 Hz to 100 kHz to monitor moisture‑induced leakage, and high‑voltage breakdown testing under saline immersion to assess dielectric strength. After aging, all electrodes maintained impedance …
Analysis Of Shotshell Breech Face Impressions Using A Computer-Based Algorithm, Carly Renee Smith
Analysis Of Shotshell Breech Face Impressions Using A Computer-Based Algorithm, Carly Renee Smith
Graduate Theses, Dissertations, and Problem Reports (ETD)
Forensic firearm analysis involves the comparison of test fires from a suspect firearm to an unknown sample, typically collected from a crime scene. Test fires and the unknown sample are examined for agreement in class characteristics and sufficient agreement in individual characteristics using a comparison microscope. The forensic analysis of firearms has been challenged both in court and by governmental organizations for its subjective nature and the inability to accurately report error rates.
To combat these challenges, the National Institute of Standards and Technology (NIST) has proposed using computer-based algorithms, such as Congruent Matching Cells (CMC). These CMC algorithm calculates …
Global China In Pakistan: Mixed-Methods Analysis Of Symbolic Domination, Social Media Geopolitics, And Security Corridors, Davide Giacomo Zoppolato
Global China In Pakistan: Mixed-Methods Analysis Of Symbolic Domination, Social Media Geopolitics, And Security Corridors, Davide Giacomo Zoppolato
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation explores the discursive and material dimensions of China’s global rise through a case study of the Belt and Road Initiative (BRI) in Pakistan. As China becomes a leading provider of development finance, its infrastructure-led approach is reshaping geographies across the Global South. Focusing on the China–Pakistan Economic Corridor (CPEC)—the BRI’s flagship project—I examine how Chinese and Pakistani actors co-produce development through discourses, infrastructures, and security regimes. Structured around three articles, the dissertation analyzes: (1) the official diplomatic discourses of Chinese state institutions and their reception by Pakistani media outlets; (2) the curated geopolitical discourses of Chinese social media …
Leveraging Physiological Signal Activity And Self-Report Data To Assess Students’ Trust In “My Friendly Mind” App And Its Impact On Their Mental Health Knowledge: A Mixed-Method Phase 1 Clinical Trial Focusing On Depression And Attention Deficit Hyperactivity Disorder From Human Factors Standpoint., Yeganeh Shahsavar
Graduate Theses, Dissertations, and Problem Reports (ETD)
Mental health issues have become a significant global public health concern, especially among younger generations. The growing number of mental health challenges, combined with limited access to quality care, makes the problem even worse. Studies reveal that over 70% of individuals worldwide in need of mental health services do not receive appropriate care. Digital health technologies have the potential to enhance mental health services by making them more accessible and affordable. Despite the increasing popularity of mental health mobile applications (mHealth), there remains a lack of robust evidence of their effectiveness and the level of user trust, particularly in areas …
P23h Rhodopsin Accumulation Disrupts Synaptic Protein Levels In Rod Photoreceptors, Samantha Thompson
P23h Rhodopsin Accumulation Disrupts Synaptic Protein Levels In Rod Photoreceptors, Samantha Thompson
Graduate Theses, Dissertations, and Problem Reports (ETD)
Rod photoreceptors are specialized neurons located in the retina, the neural tissue that lines the back of the eye. Rod photoreceptors are necessary for dim light and peripheral vision through the photoactivation rhodopsin (Rho). Rho is synthesized in the inner segment of rods before being unidirectionally trafficked to the outer segment. In diseases such as retinitis pigmentosa (RP), Rho trafficking can be disrupted, leading to progressive rod cell death. In many cases of RP, Rho is mislocalized to the rod photoreceptor synapse (“spherule”). The impact of Rho mislocalization on spherule structure and protein organization is poorly understood. We hypothesize that …
Introduction Of Polar Functional Groups To Pyridinedipyrrolide Zirconium Photosensitizers Through Post-Synthetic Modifications, Marisa Nicole Tordella
Introduction Of Polar Functional Groups To Pyridinedipyrrolide Zirconium Photosensitizers Through Post-Synthetic Modifications, Marisa Nicole Tordella
Graduate Theses, Dissertations, and Problem Reports (ETD)
Photosensitizers are vital components to applications such as photoredox catalysis, photodynamic therapy, and various avenues of solar energy production. The abilities of transition metal photosensitizers containing precious metals have been well studied over the years. However, because of the growing scarcity of these metals, there has been a shift in finding more earth abundant alternatives. To help fill this gap in the literature, the Milsmann group has developed and studied the photophysical properties of Zr(IV) complexes with various ligand systems. Due to the electron deficient metal center, these complexes exhibit ligand-to-metal charge transfer (LMCT), unlike the metal-to-ligand charge transfer commonly …