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Graduate Theses, Dissertations, and Problem Reports (ETD)

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Long-Term Evaluation Of Permanent Seeding And Mulching Practices, Marissa A. Poultney Jan 2017

Long-Term Evaluation Of Permanent Seeding And Mulching Practices, Marissa A. Poultney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Vegetation cover is required on disturbed land resulting from construction activities. The West Virginia Division of Highways (WVDOH) specifications for seeding and mulching currently includes seed mixtures that contain species that are considered highly invasive by the West Virginia Division of Natural Resources (WVDNR). This work evaluated the use of experimental seed mixtures at roadside locations by considering two major objectives: i) evaluating long-term performance of experimental mixtures over multiple growing seasons, and ii) investigating sediment yield from vegetation cover practice.;First, vegetation growth and persistence from four small-scale field plots were monitored through the second and third growing seasons. The …

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Core Flight System Cryptography Library, John Patrick Lucas Jan 2017

Core Flight System Cryptography Library, John Patrick Lucas

Graduate Theses, Dissertations, and Problem Reports (ETD)

The NASA Independent Verification and Validation (IV&V) Program has been tasked with performing testing for the Consultative Committee for Space Data Systems (CCSDS) Space Data Link Security (SDLS) Extended Procedure (EP) protocol. This testing has allowed for both the expansion of inter-agency collaboration and the publishing of the SDLS-EP Standard. This protocol is a "data processing method for space missions that need to apply authentication and/or confidentiality to the contents of Transfer Frames used by the Space Data Link Protocols over a space link" (CCSDS) . The interest for security on satellites stems from threats including but not limited to …

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The Investigation Of Motor Primitives During Human Reaching Movements And The Quantification Of Post-Stroke Motor Impairment, Erienne Virginia Olesh Jan 2017

The Investigation Of Motor Primitives During Human Reaching Movements And The Quantification Of Post-Stroke Motor Impairment, Erienne Virginia Olesh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Movement is a complex task, requiring precise and coordinated muscle contractions. The forces and torques produced during multi-segmental movement of the upper limbs in humans, must be controlled, in order for movement to be achieved successfully. Although a critical aspect of everyday life, there remain questions regarding the specific controller used by the central nervous system to govern movement. Furthermore, how this system is affected by neurological injuries such as stroke also remains in question. It was the goal of this thesis to examine the neurological control of movement in healthy individuals and apply these findings to the further investigation …

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A Pedagogical Study Of Selected Piano Music Of Miguel Del Aguila, Sornsuang Tangsinmonkong Jan 2017

A Pedagogical Study Of Selected Piano Music Of Miguel Del Aguila, Sornsuang Tangsinmonkong

Graduate Theses, Dissertations, and Problem Reports (ETD)

Miguel del Aguila (b. 1957) is an Uruguayan American composer who was nominated three times for Grammy Awards. He considers himself a postmodernist composer. His music shows various stylistic traits and strong influence from Latin American folk dances.;This research project focuses on the pedagogical study of eight piano compositions of Miguel del Aguila: "Toccata", Op. 23 (1988) Piano Sonata No.2, Op. 29 (1988) Conga, Op. 39 (1993) "Vals Brutal", Op. 48 (1995) Piano Concerto, Op. 57 (1997) "Nocturne", Op. 62 (1998) "Music in a Bottle", Op. 67 (1999) "Half of Me", Op. 68 (2000).;This study includes a discussion of del …

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Inference Of Biogeographical Ancestry Under Resource Constraints, Tanjin Taher Toma Jan 2017

Inference Of Biogeographical Ancestry Under Resource Constraints, Tanjin Taher Toma

Graduate Theses, Dissertations, and Problem Reports (ETD)

We study the problem of predicting human biogeographical ancestry using genomic data. While continental level ancestry prediction is relatively simple using genomic information, distinguishing between individuals from closely associated sub-populations (e.g., from the same continent) is still a difficult challenge. In particular, we focus on the case where the analysis is constrained to using single nucleotide polymorphisms (SNPs) from just one chromosome. We thus propose methods to construct ancestry informative SNP panels analyzing variants from a single chromosome, and evaluate the performance of such panels for both continental-level and sub-continental level ancestry prediction.;Efficient selection of ancestry informative SNPs is the …

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Think Twice Before Hitting 'Send': The Strategic Uses Of Information In Marketing Channels, Pui Ying Tong Jan 2017

Think Twice Before Hitting 'Send': The Strategic Uses Of Information In Marketing Channels, Pui Ying Tong

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation examines the growing problem of information overload in the context of marketing channels. Information overload occurs when shared information requires more mental resources to process than the mental resources available to the receiver. This research offers strategies to attenuate information overload and examines the impact of information overload on channel outcomes. Strategic uses of information are proposed and conceptualized as a sender's alteration of information volume, content, and/or timing to assist a receiver in processing information. Hypotheses are developed based on the normative perspective of communication from the organizational communication literature. Data from 244 salespeople are analyzed using …

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A Study Of The Correlation Between Static And Dynamic Modulus Of Elasticity On Different Concrete Mixes, Logan Trifone Jan 2017

A Study Of The Correlation Between Static And Dynamic Modulus Of Elasticity On Different Concrete Mixes, Logan Trifone

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study is to determine the relationship between the Static Modulus of Elasticity and the Dynamic Modulus of Elasticity in various concrete mixes. The Static Loading Test was used to measure the strains associated with applied stresses on cylindrical concrete specimens to determine the Static Modulus. An Ultrasonic Pulse Wave Velocity (UPV) technique was utilized to measure the travel time of pulse waves propagating through rectangular prism specimens. The travel times were used to compute the Dynamic Modulus of Elasticity. An Impact Hammer measuring device was also used to measure resonance frequencies of vibrations in rectangular prisms, which also correlate …

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All The Single Ladies: Christina Of Markyate And The Importance Of Spiritual Guidance In Medieval England, Courtney Weaver Jan 2017

All The Single Ladies: Christina Of Markyate And The Importance Of Spiritual Guidance In Medieval England, Courtney Weaver

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis analyzes the Life of Christina of Markyate to illustrate how the pages of Christina's manuscript contain keys to a better understanding of issues of sex, gender, and religion in the Middle Ages, especially in regards of how space, enclosure, and spiritual guidance were used by medieval religious people to further their devotional practices. By explicating the nature of Christina's enclosure experiences, we see how her life serves as an example of the importance of spiritual guidance in medieval lives. Christina's recorded experience of enclosure can help us grasp the significant role that space played in helping advance opportunities …

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Detection And Persistence Of Gunshot Residue (Gsr) On Facial Features Using Semedx, Samuel Yatzkan Jan 2017

Detection And Persistence Of Gunshot Residue (Gsr) On Facial Features Using Semedx, Samuel Yatzkan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The goal of this research project was to examine the ability to detect gunshot residue (GSR) from a person's face and determine if there was any statistical difference in the amount of GSR persisting on the face versus the amount persisting on a shooter's hands over time since the discharge of the firearm. From an investigative viewpoint, the presence of GSR could indicate some involvement with a firearm and warrant further investigation into the person of interest. Within this research, participants fired 1 round of ammunition from a firearm and after a designated amount of time had passed, were sampled …

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Biochemical Characterization Of The Release Of Fak Autoinhibition, Jessica E. Hall Jan 2017

Biochemical Characterization Of The Release Of Fak Autoinhibition, Jessica E. Hall

Graduate Theses, Dissertations, and Problem Reports (ETD)

Focal adhesion kinase is an essential nonreceptor tyrosine kinase that plays an important role in development, in homeostasis and in the progression of human disease. Multiple stimuli activate FAK, which requires a change in structure from an autoinhibited to activated conformation. In the autoinhibited conformation the FERM domain associates with the catalytic domain of FAK and PI(4,5)P2 binding to the FERM domain plays a role in the release of autoinhibition, activating the enzyme. This work aims to better characterize the residues involved in the release of the autoinhibitory conformation. The first aim was to characterize the effects of point mutations …

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A Study Of The Fast Radio Burst Population, Akshaya Rane Jan 2017

A Study Of The Fast Radio Burst Population, Akshaya Rane

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fast Radio Bursts (FRBs) are a new class of astrophysical phenomena discovered a decade ago that are characterized by extremely bright millisecond duration radio bursts originating in external galaxies. We have processed archival pulsar survey data obtained with the 64-m Parkes radio telescope in Australia. We used the single-pulse search method to search for pulsars, rotating radio transients (RRATs), and FRBs. RRATs are Galactic pulsars that emit sporadic pulses. We detected 20 known pulsars and one RRAT in this analysis but we did not find any FRBs. We combined this null result with the previous searches carried out with Parkes …

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War On The Mind: Trauma And Coping Among Union Soldiers And Veterans, Kathleen Anneliese Logothetis Thompson Jan 2017

War On The Mind: Trauma And Coping Among Union Soldiers And Veterans, Kathleen Anneliese Logothetis Thompson

Graduate Theses, Dissertations, and Problem Reports (ETD)

"War on the Mind: Trauma and Coping in the Union Army," is a work of social, cultural, and military history and examines experiences of mental trauma in the Union Army during the war and among veterans in the post-war period. Without our modern definition of Post-Traumatic Stress Disorder, Civil War soldiers had a very different view of how they were mentally experiencing the war. By looking at soldier accounts and the records of insane asylums it is clear that soldiers did have experiences of trauma and insanity during or related to their wartime service. However, those same asylum records, as …

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Using Artificial Neural Networks To Predict Formation Stresses For Marcellus Shale With Data From Drilling Operations, Mousa S. Mohamed Abusurra Jan 2017

Using Artificial Neural Networks To Predict Formation Stresses For Marcellus Shale With Data From Drilling Operations, Mousa S. Mohamed Abusurra

Graduate Theses, Dissertations, and Problem Reports (ETD)

Artificial neural networks have been applied to different petroleum engineering disciplines. This is contributed to the powerful prediction capability in complex relationships with enough data available. The objective of this study is to develop a new methodology to predict the vertical and horizontal stresses using artificial neural networks for Marcellus shale well laterally drilled in Monongalia County, WV.;This approach coupled the drilling surface measurements with the recorded well logging data. Drilling parameters included depth, WOB, RPM, standpipe pressure, torque, pump flow rate and rate of penetration. Well logging data included gamma ray and bulk density. The model output was the …

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Impacts Of Boundary Conditions On Premixed Combustion In Obstructed Conduits: A Computational Analysis, Rawan Ibrahim Alkandari Jan 2017

Impacts Of Boundary Conditions On Premixed Combustion In Obstructed Conduits: A Computational Analysis, Rawan Ibrahim Alkandari

Graduate Theses, Dissertations, and Problem Reports (ETD)

Premixed flame acceleration in channels or pipes has various practical applications, starting with fire safety problems and ending with advanced technologies such as pulse-detonation engines. In particular, a flame accelerates extremely fast when propagating through a comb-shaped array of narrow, tightly-spaced obstacles in a so-called "Bychkov tube". In the present thesis, the role of boundary conditions in such geometry is studied by means of the comprehensive computational simulations of combustion equations, with a fully-compressible hydrodynamics and an Arrhenius chemical kinetics. Specifically, the mechanistic (slip/nonslip) and thermal (adiabatic/isothermal) conditions at the walls/obstacles' surfaces, as well as the boundaries at the conduits' …

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Stochastic Geometry Analysis Of A Class Of Cooperative Relaying Protocols, Sri Lakshmi Phani Balineni Jan 2017

Stochastic Geometry Analysis Of A Class Of Cooperative Relaying Protocols, Sri Lakshmi Phani Balineni

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis examines wireless relay networks that use hybrid-ARQ protocols. Relays networks efficiently combat fading and exploit the spatial diversity present in the channel. Hybrid-ARQ involves retransmitting the signal if it is not decoded correctly. In conventional HARQ, the retransmission comes from the source, but in cooperative HARQ the retransmission could come from a relay that has successfully decoded the message, thus attaining transmit diversity.;A Markov chain model is conceived and used to compute the effective throughput and outage probability in the presence of Rayleigh fading. The analytical results are validated with simulations. The spatial configuration of the network plays …

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Associations Between Sleep, Infant Feeding Methods, Brain Development And Behavior: A Multimodal Approach To Assess Plasticity In The Brain, Christopher Edward Bauer Jan 2017

Associations Between Sleep, Infant Feeding Methods, Brain Development And Behavior: A Multimodal Approach To Assess Plasticity In The Brain, Christopher Edward Bauer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Purpose: Sleep-disordered breathing (SDB) is a spectrum disorder that is estimated to effect a significant proportion of the pediatric population (1-3% in USA). SDB is able to disrupt and fragment sleep through frequent arousals and intermittent hypoxia. In addition, the long term effects of SDB in pediatrics have been well-documented; decreases in intelligence quotient (IQ), executive function, school performance, and alertness have all been observed. Although surgical treatments can be quite effective, there are no widely accepted prophylactic measures to prevent SDB development. Recently, breastfeeding duration in infancy has been demonstrated to be correlated with reduced SDB (lower AHI, RAI, …

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Using A Species Distribution Model And Site-Specific Microclimatic Variables To Model Presence Of Spodic Soil Properties And Relative Occurrence Rate Of Picea Rubens (Red Spruce) To Inform Red Spruce Management, Adrienne Nottingham Jan 2017

Using A Species Distribution Model And Site-Specific Microclimatic Variables To Model Presence Of Spodic Soil Properties And Relative Occurrence Rate Of Picea Rubens (Red Spruce) To Inform Red Spruce Management, Adrienne Nottingham

Graduate Theses, Dissertations, and Problem Reports (ETD)

Red spruce restoration efforts in the central Appalachians are of interest to land managers because of the reduced current extent and the numerous ecosystem services provided by red spruce forests. These land managers require information regarding the best places to focus restoration efforts. Studies attempting to locate optimal locations for red spruce restoration have been conducted to in the central Appalachians, most of which utilize modeling. In particular, podzolization, a soil formation pathway present under conifer vegetation in the central Appalachians has been used to help select areas for red spruce restoration. The effectiveness of using recent podzolization (as evidenced …

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A Low-Power Optoelectronic Characterizer For Cubesat: Locc And Iii-V Nitride Based Leds, Matthew J. Pachol Jan 2017

A Low-Power Optoelectronic Characterizer For Cubesat: Locc And Iii-V Nitride Based Leds, Matthew J. Pachol

Graduate Theses, Dissertations, and Problem Reports (ETD)

III-V semiconductor materials exhibit robustness and natural hardness when exposed to ionizing radiation and temperature swings. With these characteristics in mind, III-V Nitride Light Emitting Diodes (LEDs) are ideal devices for space-based applications and missions. The effects of ionizing radiation on optoelectronic devices comprised of III-V materials have been studied, but results have been obtained through experiments performed in terrestrial laboratories. While these laboratory tests may lend insight into device lifetimes, performance degradation, etc., they are no substitute for similar measurements and characterization performed in space.;Interest in small satellite applications have grown over the past decade. These solutions range from …

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Exploring Concentration And Duration Dependence In Hormesis, Maren S. Prediger Jan 2017

Exploring Concentration And Duration Dependence In Hormesis, Maren S. Prediger

Graduate Theses, Dissertations, and Problem Reports (ETD)

The phenomenon of hormesis, characterized by beneficial low-exposure stress-protective effects, has experienced increasing interest by the scientific community. Elucidating the underlying cellular signaling pathways that lead to a new homeostatic state can provide crucial information about new therapeutic targets to prevent and treat diseases. Commonly investigated for hormetic behavior are plant-based substances (phytochemicals), such as quercetin, epigallocatechin gallate, curcumin, and resveratrol. The polyphenol resveratrol, found in peanuts, grapes, and subsequently in wine, is known for a variety of effects---beneficial and detrimental---depending on the investigated cell type and concentration. In HepG2 cells, an increase in proliferation has been observed previously at …

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Development Of Techniques For Assessment Of Population Characteristics Of The Federally Endangered Diamond Darter, Austin A. Rizzo Jan 2017

Development Of Techniques For Assessment Of Population Characteristics Of The Federally Endangered Diamond Darter, Austin A. Rizzo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Population monitoring is an essential component of endangered species recovery programs. One species for which monitoring is needed is the federally endangered Diamond Darter Crystallaria cincotta. This species was placed on the Endangered Species List in 2013 because of its small range and population size, and because of continued anthropogenic threats to the species' habitat. The Diamond Darter is believed to occur only within the lower 50 rkm of the Elk River in West Virginia. Museum specimens indicate the Diamond Darter was once distributed throughout the Ohio River Basin, but it is now likely extirpated from the Muskingum River, the …

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The Potential Impact Of Art Therapy Approaches In An Alternative Learning School Setting In Urban West Virginia, Brianna Saddler Jan 2017

The Potential Impact Of Art Therapy Approaches In An Alternative Learning School Setting In Urban West Virginia, Brianna Saddler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Now more than ever American adolescents are suffering from severe anxiety (Lewis, 2017). In the past, over-achieving students were those parents least worried about when it came to experiencing anxiety but now studies show these students are just as likely to experience anxiety as those learners considered to be underachievers. The purpose of this paper is to inform the reader how art therapy approaches embedded into daily lesson plans could be used in alternative learning school settings to help students deal with anxiety. Through my own experiences as a practicing art teacher in both general education art classrooms and alternative …

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A Conductor's Perspective On Stravinsky's "Danse Sacrale" From "Le Sacre Du Printemps": Evaluation Of Revisions, Analysis And Considerations For Conducting, Hanjin Sa Jan 2017

A Conductor's Perspective On Stravinsky's "Danse Sacrale" From "Le Sacre Du Printemps": Evaluation Of Revisions, Analysis And Considerations For Conducting, Hanjin Sa

Graduate Theses, Dissertations, and Problem Reports (ETD)

The final dance, Danse sacrale from the ballet Le Sacre du printemps by Igor Stravinsky (1882-1971) presents various challenges for conductors: both textual and technical. For the textual challenges, this research paper focuses on the comparative studies of various revisions, the early sketchbook, and the autograph full score. The study of correspondence between Stravinsky and the early conductors of Le Sacre (Pierre Monteux and Ernest Ansermet) also offers important clues for solving the puzzle with which Stravinsky himself had struggled for decades.;Both the 1943-revised version and Nicholas Slonimsky's re-barring of the Danse sacrale will be closely examined. Despite Stravinsky's wish …

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Three Essays On Corruption, Sumi Sharma Jan 2017

Three Essays On Corruption, Sumi Sharma

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation examines the link between market competition and corruption for developing countries and top income inequality and corruption in the US. The first two chapters explore the link between firm-level markup and corruption for a global dataset. I test the hypothesis that high-markup firms are less likely to engage in corruption. To investigate this relationship, I use firm-level data from World Bank Enterprise Survey (WBES) for 95 developing countries from 10 manufacturing industries. I find that high markup firms that operate in less competitive environments are less likely to bribe. These results are robust across three other measures of …

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North-East Indian Monsoon Rainfall Variability Over Southeastern Peninsular India, Jothiganesh Shanmugasundaram Jan 2017

North-East Indian Monsoon Rainfall Variability Over Southeastern Peninsular India, Jothiganesh Shanmugasundaram

Graduate Theses, Dissertations, and Problem Reports (ETD)

North-East Indian Monsoon rainfall (NEIMR) during October-December is of immense socio-economic importance to the agriculture dependent population in the southeastern peninsular India. NEIMR is subject to extreme year-to-year and intra-seasonal variability that needs to be understood to enhance climate resilience. An understanding of NEIMR variability and the physical processes behind this variability would help to improve the predictability of NEIMR variation over the southeastern peninsular of India. An insight into past societal responses to monsoon variability would be a great lesson for adapting to future climate challenges. This dissertation seeks to examine the intra-seasonal variability of NEIMR and its driving …

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Cardiac And Mitochondrial Dysfunction During Diabetes Mellitus: Examination Of Mitochondrial Import Mechanisms, Danielle Lee Shepherd Jan 2017

Cardiac And Mitochondrial Dysfunction During Diabetes Mellitus: Examination Of Mitochondrial Import Mechanisms, Danielle Lee Shepherd

Graduate Theses, Dissertations, and Problem Reports (ETD)

Approximately 9% of the United States population is diagnosed with diabetes mellitus (DM), which is comprised of 2 distinct pathologies: type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). T1DM, which is caused by insufficient insulin production, affects approximately 5% of diabetic patients, while T2DM results from insulin resistance and affects 95% of all diabetic patients. Within diabetic patients, cardiac complications, such as diabetic cardiomyopathy, are the leading cause of morbidity and mortality. The mitochondrion has been implicated as an underlying factor in the etiology and progression of the cardiac contractile deficits and cardiac failure that accompany DM. …

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Investigating Social Perceptions Associated With Water Quality In Morgantown, West Virginia, Jonas G. Leveque Jan 2017

Investigating Social Perceptions Associated With Water Quality In Morgantown, West Virginia, Jonas G. Leveque

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation investigates public perceptions of water quality in Morgantown, West Virginia. In recent years, water has become an increasingly critical issue in terms of quantity worldwide, and also in terms of quality. In developed countries such as the United States, water quality is often taken for granted by the general public. Nonetheless, recent water crises in Flint, Michigan and Charleston, West Virginia, are examples showing there are environmental risks associated with human activities. This dissertation explores the context of West Virginia, with coal mining that is decreasing and non-conventional oil and gas drilling that is increasing in the Appalachia …

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Subspace Representations And Learning For Visual Recognition, Farzad Siyahjani Jan 2017

Subspace Representations And Learning For Visual Recognition, Farzad Siyahjani

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pervasive and affordable sensor and storage technology enables the acquisition of an ever-rising amount of visual data. The ability to extract semantic information by interpreting, indexing and searching visual data is impacting domains such as surveillance, robotics, intelligence, human- computer interaction, navigation, healthcare, and several others. This further stimulates the investigation of automated extraction techniques that are more efficient, and robust against the many sources of noise affecting the already complex visual data, which is carrying the semantic information of interest. We address the problem by designing novel visual data representations, based on learning data subspace decompositions that are invariant …

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Design, Construction, And Analysis Of A Pilot-Scale Automated Drilling Platform, Cody Smith Jan 2017

Design, Construction, And Analysis Of A Pilot-Scale Automated Drilling Platform, Cody Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

This project and the associated research investigates automation techniques for drilling operations, along with the analysis involved in building an automated pilot-scale drilling platform. The outcome from this research investigates feasible technologies and techniques that can be used to automate a pilot-scale drilling rig, with the intent that these practices may provide insight into the construction or procedures of full scale rigs. Both the theory and lab exercise components of this research were completed in association with the Drillbotics competition sponsored by the Drilling Systems Automation Technical Section (DSATS) committee of the Society of Petroleum Engineers (SPE). This study includes …

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A New Compactification For Celestial Mechanics, Daniel Solomon Jan 2017

A New Compactification For Celestial Mechanics, Daniel Solomon

Graduate Theses, Dissertations, and Problem Reports (ETD)

This is an exposition of a new compactification of Euclidean space enabling the study of trajectories at and approaching spatial infinity, as well as results obtained for polynomial differential systems and Celestial Mechanics. The Lorenz system has an attractor for all real values of its parameters, and almost all of the complete quadratic systems share an interesting feature with the Lorenz system.;Informed by these results, the main theorem is established via a contraction mapping arising from an integral equation derived from the Celestial Mechanics equations of motion. We establish the existence of an open set of initial conditions through which …

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Endoplasmic Reticulum Stress Is Transmissible Among Cells Of The Central Nervous System, Neil T. Sprenkle Jan 2017

Endoplasmic Reticulum Stress Is Transmissible Among Cells Of The Central Nervous System, Neil T. Sprenkle

Graduate Theses, Dissertations, and Problem Reports (ETD)

Improper protein folding and trafficking are common pathological events observed in various cell types in neurodegenerative diseases. If the protein quality control mechanisms of the endoplasmic reticulum (ER) fail to re-establish proteostasis, misfolded proteins accumulate within the lumen of the ER and perturb normal cellular processes. While low-level stimulation of the unfolded protein response (UPR) is considered a beneficial physiological response to transient protein misfolding stress, or ER stress, sustained UPR activation resulting from prolonged ER stress can promote neurotoxicity. The cell-autonomous mechanisms of the UPR have been extensively characterized in the context of neuropathology. Nevertheless, there still remain unanswered …

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