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Silver-Mediated Decarboxylation Reactions: Expanding Reaction Scope Through Kinetic Analysis, Robert Anthony Crovak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Transition metal-catalyzed decarboxylative coupling reactions have received considerable attention in recent years as a method to obtain biaryl compounds. However, the oxidative version of this reaction class is still in its infancy, limited to specific substitution patterns on the benzoic acids – ortho-substitution - used in these transformations. This thesis describes our attempts to understand the key decarboxylation step of this important class of reactions. The first chapter of this thesis discusses an introduction into cross-coupling reactions, decarboxylative cross-coupling reactions, and outlines relevant physical organic parameters. The following chapter details the synthesis of a series of (1,10-phenanthroline)silver(benzoate) complexes. This chapter …

Examining Provider-Patient Communication And Family Knowledge Of Treatment In Pediatric Asthma Care, Thomas W. Ewell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Asthma knowledge is an essential factor in being able to consistently and effectively manage asthma symptoms over time, which in turn reduces asthma morbidity and improves quality of life. The way in which certain provider factors, such as communication strategies or techniques, may differentially impact pediatric patients and their caregivers has little in the way of prior investigation. The current study involves a secondary analysis from a larger project. This larger study included 45 pediatric asthma patients (ages 8-17 years; M = 11.79) and their primary caregiver recruited from pediatric asthma and allergy clinics within the WVU Medicine system to …

Mechanistic Analysis Of Reductive Boracarboxylation Using Low Valent Copper And Co2, Notashia Nicole Baughman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The synthesis of organoboron compounds is of contemporary importance in the chemistry community given their utility in subsequent functionalization reactions as well as their growing therapeutic potential in the treatment of human disease. This, coupled with the ubiquity of carboxylic acid functional groups in pharmaceuticals and fine chemicals, has led to interest in one-pot difunctionalization reactions using CO₂ and a boron source. An (ICy)copper(I)-catalyzed boracarboxylation reaction was recently developed wherein CO₂ and a pinacolboryl group is added across the double bond of vinyl arenes was recently developed, providing access to α-aryl-β-boryl propionic acid derivatives. A subsequent publication detailed …

Examining The Career Pathways For Women Administrators At A Land-Grant University, Meridith A. Balas

Graduate Theses, Dissertations, and Problem Reports (ETD)

This feminist-centered, narrative study focuses on the troubling gender gaps in higher education leadership by exploring the career paths and lived experiences of current women administrators at a large, public land-grant institution. This research identifies specific supports and barriers women face throughout their careers that might enable or prevent them from attaining or accessing high-level leadership roles in academic and non-academic administration. The study leans on feminist theory to position perceptions of women in leadership roles across many disciplines in the university setting while observing it as a critical lens to analyze gender inequality in the career pipeline for women …

Cerebrovascular Dysfunction And Degeneration In Alzheimer’S Disease Pathophysiology, Dominic Dimitri Quintana

Graduate Theses, Dissertations, and Problem Reports (ETD)

Alzheimer’s disease (AD) is a terminal illness and the most common form of dementia, which disproportionately affects the aged population. The pathophysiology of AD is characterized by neurodegeneration that slowly progresses, affecting regions of the brain that are involved in learning, memory, language, and executive function. In patients with the disease, early symptoms include non-disruptive forgetfulness that evolves into the inability to form new memories and ultimately the loss of autonomy at late stages. Histopathological hallmarks in the brain from patients with AD is the presence of amyloid-β (Aβ)-plaques and neurofibrillary tangles (NFT) deposited in the parenchyma. Since the discovery …

"Treading On The Footprints Of History": American Catholic Pilgrimage As Public History, Charlotte Vester

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this thesis, I demonstrate how Catholic pilgrimage is a public history phenomenon. I define public history as public engagement, understanding, and use of the past. While I assert that pilgrimage is a public history phenomenon both in the past and in the present, my thesis will focus on American Catholic pilgrimage at the turn of the twentieth century. Each individual chapter will demonstrate that through pilgrimage, the faithful are engaged in public history in its various forms. Catholics actively took part in past-making and identity-construction in their roles as pilgrims. Through pilgrimage, Catholics were involved in the preservation and …

Solutions To Some Mine Subsidence Research Challenges, Jian Yang

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this work is to address three challenging topics, (1) effects of overburden key strata on subsurface subsidence; (2) effects of longwall subsidence on interstate highways and highway bridges; and (3) effects of dewatering mine water on surface subsidence over inactive room-and-pillar mines, in mine subsidence and to continue improvement of mine safety and health by reducing mine-subsidence related hazards.

Surface and subsurface subsidence events induced by underground mining activities are often capable of causing significant disturbances not only to surface structures, but also to subsurface structures. In this work, models and techniques to study three challenging topics …

Terrain Aware Traverse Planning For Mars Rovers, Gabrielle Hedrick

Graduate Theses, Dissertations, and Problem Reports (ETD)

NASA is proposing a Mars Sample Return mission, to be completed within one Martian year, that will require enhanced autonomy to perform its duties faster, safer, and more efficiently. With its main purpose being to retrieve samples possibly tens of kilometers away, it will need to drive beyond line-of-sight to get to its target more quickly than any rovers before. This research proposes a new methodology to support a sample return mission and is divided into three compo-nents: map preparation (map of traversability, i.e., ability of a terrain to sustain the traversal of a vehicle), path planning (pre-planning and replanning), …

A Study Of Impact Protection Of Metacarpal Gloves, Faisal Mohammed Alessa

Graduate Theses, Dissertations, and Problem Reports (ETD)

Work-related wrist, hand, and finger injuries are highly prevalent in manufacturing and extractive industries. An analysis of mining-related hand injury data from over the past two decades (Alessa et al., 2020) showed that hand injuries caused by insufficient protection against impact loads (e.g. struck by accidents) were categorized with high severity. Existing literature lacks clear classification and quantification methods for the protection provided by impact-resistant gloves (i.e. metacarpal gloves). A new method to establish a quantitative measure of performance for commonly used metacarpal gloves was developed and evaluated.

In the first specific aim, an experimental study using cadaveric hand specimens …

Behavior Coaching In Pennsylvania Schools Implementing School-Wide Positive Behavior Interventions And Supports At The Universal Tier One Level, Lisa Anderson

Graduate Theses, Dissertations, and Problem Reports (ETD)

School-Wide Positive Behavior Interventions and Supports (SWPBIS) is a multi-tiered system of student support that emphasizes the use of positive behavior strategies for a school’s students. Schools are adopting SWPBIS because it gives staff the opportunity to teach desired behaviors to students and emphasizes the enhancement of instructional time by minimizing disruptions. SWPBIS uses a support framework that includes a building-level behavior coach and a core team made up of an administrator, parent(s), and professional school staff. Staff and student training is bridged with implementation efforts to sustain a positive school climate and prevent student behavior problems. The SWPBIS coach …

Evaluation Of Object Attributes To Study Speed-Accuracy Trade-Off Of Gloves Using Iso 9241-411 Standard, Isha Gaut

Graduate Theses, Dissertations, and Problem Reports (ETD)

Selection of appropriate gloves plays an important role in the overall comfort and productivity of workers. Currently, there are no standards and/or guidelines available to systematically evaluate the glove performance based on speed-accuracy trade-off. The ISO 9241-411 standard which is based on Fitts’ Law has been extensively used in the literature to measure speed-accuracy trade-off in terms of throughput in the virtual environments. This study was aimed at developing guidelines for implementing ISO 9241-411 standard in the physical environment so that it can be used to estimate (and compare) throughputs of safety gloves. Specifically, the various physical attributes of objects …

The Effects Of Membrane Physicochemical Properties On Huntingtin Membrane Association And Downstream Aggregation, Maryssa Beasley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Huntington’s Disease (HD) is a fatal neurodegenerative disorder caused by an expanded glutamine repeat region (polyQ) within the huntingtin protein (htt). As a result of the expanded polyQ domain, htt associates into a variety of toxic aggregate species. The polyQ domain of htt is flanked at the N-terminal end by 17 amino acids (Nt17) that adopt an amphipathic α-helical structure in the presence of binding partners such as lipid membranes. In addition to comprising a lipid binding domain, the Nt17 amphipathic α -helix has been directly implicated in htt aggregation initiation via self-association with other Nt17 α -helices. Due to …

Effect Of Binder Modification And Aggregate Size On Modulus And Fatigue Of Asphalt Concrete, Elizabeth Bashiti

Graduate Theses, Dissertations, and Problem Reports (ETD)

Asphalt concrete is one of the main ingredients used in the paving of roadways across the globe. These roadways have been deteriorating from overuse, under design, and a lack of understanding of the engineering properties. In the asphalt community, it is agreed upon that polymer modifiers and aggregate size have comparable impacts on the performance of a pavement, such as, low creep at high temperatures, high ductility at low temperatures, high toughness, resistance to moisture and temperature, high cohesive and adhesive strength. With all of these advantages, it has been often assumed that polymer modifiers extend/improve the expected life of …

Comparison Of Condensation Nuclei Counter And Controlled Negative Pressure Methods Under Different Environmental Conditions Tested With A Mannequin And Human Subjects, Olanrewaju John Fadairo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Continuing concern about exposure to respiratory hazards at various workplaces and prevalent pandemics such as H1N1/09 influenza and COVID-19, have necessitated a need for more research regarding respirators. Quantitative fit testing (QNFT) is a critical component of an OSHA compliant respiratory protection program. QNFTs are often performed in environments where temperature and relative humidity (RH) vary. However, no study has investigated the possible effects of these parameters on penetration and QNFT results.

This comparative study utilized condensation nuclei counter (CNC) and controlled negative pressure (CNP) methods to quantitatively determine simulated mannequin fit factors (SMFFs) and human fit factor (HFFs) using …

Association Of Diet Quality With Fall Risk Among Community-Dwelling Older Adults In A Fall-Prevention Program, Jae Hyun Kim

Graduate Theses, Dissertations, and Problem Reports (ETD)

Falls are a serious threat to older adults' quality of life. Evidence is lacking regarding the influence of diet on fall risk factors. This study aims to assess the relationship between diet, functional measures, and fall risk among older adults participating in a fall-prevention intervention. Cross-sectional analysis of baseline data from 192 participants with an average age of 70.9 years was conducted using Chi-square tests, t-test, Wilcoxon test, and nominal logistic analysis. Based on Dietary Screening Tool (DST) scores, 39.5% of participants were classified as nutritionally being “at-risk,” 46.1% were at “possible-risk,” and 14.4% were “not-at-risk.” Fall risk was assessed …

Modeling Of Rotary Packed Beds For Reactive And Non-Reactive Systems, Chinyere Evangeline Ezeobinwune

Graduate Theses, Dissertations, and Problem Reports (ETD)

Rotary packed beds (RPBs) are used in a wide range of reactive and non-reactive applications. In this research, a 2-d, first-principles, dynamic model of a non-reactive RPB that is used for heat exchange between the outgoing flue gas from a power plant and the incoming air to the boiler/pulverizer of the power plant is developed. A 2-d, first-principles model of a reactive RPB is developed where a functionalized metal-organic framework (MOF) is used for CO₂ capture.

For the non-reactive system, a Ljungstrom-type air preheater (APH) is considered. Existing models for these rotating heat exchangers are typically 1-d. There are …

Estimating The Age Of A Bloodstain Using Mitochondrial Rrna, Jordan R. Flesher

Graduate Theses, Dissertations, and Problem Reports (ETD)

DNA evidence is considered the gold standard of evidence in forensic investigations. DNA is one of the most highly discriminatory pieces of evidence found at crime scenes and can link individuals to scenes. It is not relied on to perform temporal estimates to help establish a timeline for when a crime took place. Previous studies have shown that measurement of the degradation of RNA is a potential tool to establish a temporal estimate of when a blood sample was left at a crime scene. This experiment attempts to improve on previous RNA degradation studies by evaluating the validity of mitochondrial …

Fast Decision-Making Under Time And Resource Constraints, Kyle Gabriel Lassak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Practical decision makers are inherently limited by computational and memory resources as well as the time available in which to make decisions. To cope with these limitations, humans actively seek methods which limit their resource demands by exploiting structure within the environment and exploiting a coupling between their sensing and actuation to form heuristics for fast decision-making. To date, such behavior has not been replicated in artificial agents. This research explores how heuristics may be incorporated into the decision-making process to quickly make high-quality decisions through the analysis of a prominent case study: the outfielder problem. In the outfielder problem, …

Nutrient Cycling-Tree Species Relationships In Appalachian Forests, Philip Michael Crim

Graduate Theses, Dissertations, and Problem Reports (ETD)

Since the colonization of North America by Europeans, ecosystems in Appalachia and across the continent have been in a prolonged state of flux. Areas particularly rich in natural resources, such as Appalachia, have historically borne the brunt of these swift changes, often with devastating consequences. Downwind of much of the power generation facilities of the Ohio Valley, Appalachian forests have been geographically predisposed to high rates of acidic deposition, a circumstance mitigated by the passage of Clean Air Legislation beginning in the 1970s. Nevertheless, decades of elevated nitrogen (N) and sulfur (S) inputs had a profound impact on the ecology …

Managing Paradoxes Of Ambidexterity: The Impact Of Exploration And Exploitation On Firm Performance, Lixun Su

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation examines the impacts of exploration, exploitation, and ambidexterity on firm performance in three essays. Since exploration and exploitation have their own advantages and disadvantages, there are many debates over their impacts on firm performance. To synthesize the conflicting empirical results, the first essay conducted a meta-analytic study and demonstrates that ambidexterity in the product domain increases firm performance while ambidexterity in the market domain does not significantly influence firm performance. In addition, the results show that it is not necessary for all firms (e.g., resource-constrained firms) to pursue ambidexterity. Thus, the second and third essays examine how to …

The Costume Design Process For The Phantom Tollbooth, Chloe Elizabeth Cappuccilli

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis will give an account of the costume design process for The Phantom Tollbooth at West Virginia University. Specifically, the responsibilities of the role of Costume Designer, from initial meetings to final production. This document will include research about child psychology that inspired the primary design process, specifically the influence of children’s dreams, and their relationship to toys. This information was utilized to create designs explicitly for children’s theatre audiences. I will present and evaluate the costume designs, including the design evolution until the final production. Detailing the process of costume construction while working with a costume shop. Visual …

Recalling The Georgic: Land, Labor, And Literature In American Ecological Consciousness, Sam Horrocks

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation argues that environmentalism and the environmental humanities are limited by an overinvestment in the discursive mode of pastoral, which provides the ecological logic of industrial urbanization by viewing the environment from the perspective of a leisured and alienated spectator. The pastoral mode enables environmental injustice by separating the realms of ecology and economy through a conventional elision of issues of labor and economics, rendering environmentalism unable to effect change within the spheres most important to ameliorating the pollution crisis. The pastoral mode thus frustrates the overarching goal of ecocriticism and environmentalism: we seek an ontological reunion of nature …

Aeroelasticity Of Composite Plate Wings Using Hsdt And Higher-Order Fem, Justin A. Haught

Graduate Theses, Dissertations, and Problem Reports (ETD)

The aeroelasticity of composite wings is becoming an increasingly researched topic in aircraft design, as designers continue to replace aluminum alloy components with those made of composite materials because of their favorable strength-to-weight ratio, fatigue characteristics, and corrosion resistance. Additionally, the bending-torsion coupling exhibited by composite laminates readily allow for the aeroelastic optimization of an aerodynamic structure through the process of aeroelastic tailoring. Wings made of composites materials, however, are more vulnerable to shear deformation.

The objective of the present research is to study the divergence and flutter characteristics of composite plate wings using a higher-order shear deformation theory (HSDT) …

Essays On Employment Growth, Wage Discrimination, And Marijuana Legalization, Candon Johnson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The opening chapter covers the impact of the Olympic Games on employment growth. The Olympics Games stand as the largest sporting event in the world. The Games include approximately 200 countries during the Summer Olympic Games and 90 countries competing in the Winter Games, each occurring once every four years. Potential host cities fiercely compete to host the games under the guise of economic prosperity. Event promoters claim substantial economic benefits, such as employment growth, to be had from hosting these costly games. This paper examines the impacts of the Olympic Games on employment growth rates using a synthetic control …

Examining The Use Of Mhealth Technology For Weight Management: A Hybrid Effectiveness-Implementation Trial In Family Medicine, Laurel A. Brabson M.S.

Graduate Theses, Dissertations, and Problem Reports (ETD)

Overweight and obesity are prevalent and problematic conditions in the United States and worldwide, and effective weight management interventions are underutilized. Efforts to improve weight management practices have focused almost exclusively on changing physician behavior, without considering the larger healthcare context or the reciprocal patient-physician relationship. The current study explored the possibility of leveraging technology to improve the implementation of weight management clinical practice guidelines and increase patient-physician weight management discussions. 100 patients of five family medicine physicians were randomly assigned to either complete a weight management mobile application (app) prior to their primary care visit (app condition), or to …

Blind Image Denoising Using Supervised And Unsupervised Learning, Surekha Pachipulusu

Graduate Theses, Dissertations, and Problem Reports (ETD)

Image denoising is an important problem in image processing and computer vision. In real-world applications, denoising is often a pre-processing step (so-called low-level vision task) before image segmentation, object detection, and recognition at higher levels. Traditional image denoising algorithms often make idealistic assumptions with the noise (e.g., additive white Gaussian or Poisson). However, the noise in the real-world images such as high-ISO photos and microscopic fluorescence images are more complex. Accordingly, the performance of those traditional approaches degrades rapidly on real-world data. Such blind image denoising has remained an open problem in the literature.

In this project, we report two …

Creating Positive, Negative, And Neutral Primes And Testing Their Impact On Scrupulosity Relevant Tasks And Symptoms, Kelsey Jean Evey

Graduate Theses, Dissertations, and Problem Reports (ETD)

A series of three studies was conducted to develop and validate primes to activate negative, positive, or neutral beliefs about God and to determine how these activated beliefs impact scrupulosity signs and symptoms. Scrupulosity is a specific presentation of obsessive-compulsive disorder (OCD) in which individuals become preoccupied and distressed by intrusive thoughts and images related to religious issues. Individuals with more severe scrupulosity often have more negative beliefs about God. Christianity conceptualizes God in both positive (e.g., loving, caring, and helpful) and negative (e.g., angry, judgmental, and wrathful) terms. It is therefore important to determine how more positive, negative, or …

Three Essays On Energy Economics, Alexandre Ribeiro Scarcioffolo

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation consists of three essays that explore empirical issues concerning energy prices in the United States. In particular, it analyzes the price transmission within and across different energy markets and their interactions with the overall economy. The first essay evaluates the dynamic spatial integration in the U.S. natural gas market and the relative importance of each location in the overall price discovery process. I show that the regional natural gas market is on average well-integrated in both the short- and long-runs, although market integration has declined over the past few years due to pipeline capacity constraints in an increasingly …

Evaluating Use And Preference For Performance Feedback To Teach Instructional Strategies, Natalie Jones Shuler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Written and graphical feedback may be useful tools for supporting instructors because they require fewer scheduled meetings and provide instructors with permanent performance records. Although written and graphical feedback have been effective at improving some skills (e.g., use of praise), little is known about efficacy across a wider array of skills or about teacher preferences for these feedback types. Study 1 evaluated use of written and graphical feedback to increase opportunities to respond (OTRs) provided by three instructors of equine-assisted activities and therapies. Feedback increased OTRs for all three instructors. Additionally, all instructors showed untaught increases in praise when receiving …

Identifying Structure In Introductory Topology: Diagrams, Examples, And Gestures, Keith N. Gallagher

Graduate Theses, Dissertations, and Problem Reports (ETD)

Despite the prevalence of research in calculus, linear algebra, abstract algebra, and analysis in undergraduate mathematics, the teaching and learning of general topology is a largely unexplored area of research. Although enrollment in courses like linear algebra is often higher than that of topology, the study of students’ learning and understanding of topology is of great significance to the Research in Undergraduate Mathematics Education (RUME) community. Courses in topology present many students with their first experience in axiomatic reasoning and explicit interactions with mathematical structure, itself.

I present a thorough case study of Stacey, an undergraduate taking a first course …