Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Graduate Theses, Dissertations, and Problem Reports (ETD)

Discipline
Keyword
Publication Year
File Type

Articles 1831 - 1860 of 4601

Full-Text Articles in Entire DC Network

The Role Of Self-Efficacy And Social Support In Emerging Adults' Physical Activity, Nicole M. Silva Jan 2015

The Role Of Self-Efficacy And Social Support In Emerging Adults' Physical Activity, Nicole M. Silva

Graduate Theses, Dissertations, and Problem Reports (ETD)

Emerging adulthood is a time where emerging adults develop health behaviors that persist throughout the life span (Barnett et al., 2014). However, only 55.4% of emerging adults engage in the recommended amount of physical activity each week (U.S. Department for Health and Human Services, 2013). The current study examined two factors that are associated with physical activity, specifically self-efficacy and social support, in 403 (M age = 19.25, SD = 1.12) emerging adults. Linear regressions indicated that emerging adults who reported higher levels of general self-efficacy (beta = .13, p < .05), domain self-efficacy (beta = .33, p < .05), and support from the entire social network (beta = .50, p < .001) engaged in more physical activity. Support from the entire social network still accounted for a significant portion of the variance in physical activity when accounting for general or domain self-efficacy (beta for support = .48, p < .001 and .30, p < .05, respectively). The differential effects of source of support (i.e., family and friends) and type of support (i.e., esteem support, informational support, and companionship support) were also examined. Emerging adults who reported higher levels of support from family (beta = .22, p < .001) and friends (beta = .33, p < .001) engaged in more physical activity. Although emerging adults reported receiving more esteem support from family (M = 2.95, SD = 1.23) compared to friends (M = 2.74, SD = 1.15), esteem support from friends (beta = .33, p < .001) had a larger effect on physical activity than esteem support from family (beta = .21, p < .05).


Christ In The Margins: Confronting Racism Through The (Written) Word In Post-Civil War America, Cara L. Snider Jan 2015

Christ In The Margins: Confronting Racism Through The (Written) Word In Post-Civil War America, Cara L. Snider

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation examines fictional texts of the late nineteenth century in order to recover the response of progressive Christian writers facing a growing tide of racial violence, injustice, and segregation in the postbellum decades. By investigating the works of Mark Twain, Charles Sheldon, Frances Harper, and Sutton Griggs, I argue that we gain access to a cadre of writers who sought to translate emerging strains of New Theology into practical means of race reform. They regarded their novels as sermons to the masses and saw writing as a sacred practice of communicating the Word to fellow believers; and their brand …


Digital Divide Among Pakistani Faculty Regarding Their Information And Communication Technology (Ict) Access, Kamal Ahmed Soomro Jan 2015

Digital Divide Among Pakistani Faculty Regarding Their Information And Communication Technology (Ict) Access, Kamal Ahmed Soomro

Graduate Theses, Dissertations, and Problem Reports (ETD)

The issue of digital divide is a complex and multidimensional phenomenon. It centers on various dimensions of information and communication technology (ICT) access including physical access, motivation, skills, and actual usage of digital technologies. The examination of digital divide is helpful in taking necessary measures to remove or at least minimize the problem of digital divide. The past research does not provide adequate literature on digital divide among higher education faculty especially in the context of developing countries.;I developed and validated a quantitative survey instrument to examine digital divide among higher education faculty in terms of their access to information …


Understanding The Educational Experiences Of Science Teachers In A Five-Year Teacher Education Program: A Phenomenological Study, Nitin Srivastava Jan 2015

Understanding The Educational Experiences Of Science Teachers In A Five-Year Teacher Education Program: A Phenomenological Study, Nitin Srivastava

Graduate Theses, Dissertations, and Problem Reports (ETD)

This qualitative study provides an overview of educational experiences of six in-service and three pre-service secondary science teachers in the Benedum Collaborative Five-Year Teacher Education Program at a land-grant university. The researcher interviewed secondary science teachers on the experiences they found meaningful in various program components that influenced their teacher identity, beliefs about science pedagogy, and their sense of preparedness for teaching. Document analysis of teachers' journals and lesson plans supplemented the qualitative data in addition to the researcher's role and knowledge as an outsider (non-Benedum graduate) and insider (facilitator and instructor in the technology integration based classes for one …


Design And Development Of The Wvu Advanced Technology Satellite For Optical Navigation, Miranda Straub Jan 2015

Design And Development Of The Wvu Advanced Technology Satellite For Optical Navigation, Miranda Straub

Graduate Theses, Dissertations, and Problem Reports (ETD)

In order to meet the demands of future space missions, it is beneficial for spacecraft to have the capability to support autonomous navigation. This is true for both crewed and uncrewed vehicles. For crewed vehicles, autonomous navigation would allow the crew to safely navigate home in the event of a communication system failure. For uncrewed missions, autonomous navigation reduces the demand on ground-based infrastructure and could allow for more flexible operation. One promising technique for achieving these goals is through optical navigation. To this end, the present work considers how camera images of the Earth's surface could enable autonomous navigation …


Setting The Right Tone: Benefits Of Music-Based Instruction In The Esl Classroom, Mollie Talada Jan 2015

Setting The Right Tone: Benefits Of Music-Based Instruction In The Esl Classroom, Mollie Talada

Graduate Theses, Dissertations, and Problem Reports (ETD)

Research has shown a definitive link between the cognitive processing of language and of musical sound. Music has also been shown to be an effective teaching tool in the ESL classroom. Despite the theoretical studies that draw connections between musical aptitude and linguistic ability, few studies have shown the efficacy of using music to improve student motivation and self-confidence, as well as students' perceptions of learning. The aim of this thesis was to bridge the gap between research and pedagogy and to provide student perceptions of the use of musical tasks in three aspects of their learning: (1) student self-confidence …


Soluble Oligomeric Abeta42 Affects Microglia Activation And Mitochondrial Respiration, Cong Tan Jan 2015

Soluble Oligomeric Abeta42 Affects Microglia Activation And Mitochondrial Respiration, Cong Tan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microglia activation is associated with many neurodegenerative diseases such as Alzheimer's disease (AD). When activated, microglia cells change their morphology and become phagocytic. In the Alzheimer's brain, microglia cells play an important role in scavenging plaque-damaged cells and in clearing Abeta plagues. Soluble oligomeric Abeta (oAbeta) is capable to stimulate microglia activation. In AD brain, microglia cells accumulate around senile plaques as a hallmark of the pathology. Recently, we found that mitochondrial oxidative phosphorylation is affected in a dose-dependent manner in a microglia cell line (C8-B4) and primary rat glia cell. Mitochondrial basal, maximal and spare respiration capacities increase at …


Role Of Interference And Computational Complexity In Modern Wireless Networks: Analysis, Optimization, And Design, Salvatore Talarico Jan 2015

Role Of Interference And Computational Complexity In Modern Wireless Networks: Analysis, Optimization, And Design, Salvatore Talarico

Graduate Theses, Dissertations, and Problem Reports (ETD)

Owing to the popularity of smartphones, the recent widespread adoption of wireless broadband has resulted in a tremendous growth in the volume of mobile data traffic, and this growth is projected to continue unabated. In order to meet the needs of future systems, several novel technologies have been proposed, including cooperative communications, cloud radio access networks (RANs) and very densely deployed small-cell networks. For these novel networks, both interference and the limited availability of computational resources play a very important role. Therefore, the accurate modeling and analysis of interference and computation is essential to the understanding of these networks, and …


Design, Fabrication, And Testing Of A Multi-Cycle Pulse Detonation Engine, Eli M. Thorpe Jan 2015

Design, Fabrication, And Testing Of A Multi-Cycle Pulse Detonation Engine, Eli M. Thorpe

Graduate Theses, Dissertations, and Problem Reports (ETD)

With the constant drive to improve the efficiency of systems used to generate heat and work pulse detonation engines have been explored. Pulse detonation engines can be described by the Humphrey thermodynamic cycle which, in theory, has advantages over the Brayton, Otto, and Diesel cycles.;This work is concerned with the design, fabrication, and the initial tests of a pulse detonation laboratory test bed. The test bed was designed with modularity and ease of alteration in mind while ensuring that a wide range of detonable fuel and oxidizer mixtures where able to be utilized.;Initial testing with a methane and oxygen mixture …


Facial Planes As Landmarks For Diagnosis And Treatment Planning, Jennifer Tomblyn Jan 2015

Facial Planes As Landmarks For Diagnosis And Treatment Planning, Jennifer Tomblyn

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background and Objectives: Diagnosing and treatment planning in contemporary orthodontics is based on comparing elements of craniofacial morphology to selected reference planes. Ideally, a valid reference plane should have good intra-individual reproducibility, low inter-individual variability, and good reliability. The aim of this study was to determine 1.) the reliability and reproducibility of FALL and Glabella Vertical as reference planes 2.) if Glabella Vertical can be used as a frontal reference plane and 3.) if NHO is affected by varying chin positions. Methods: Part 1) 3 judges measured 4 variables (F, FC, G, and GC) on 23 subjects at T1 and …


The Relationship Between Kinesthetic Perceptions Of Elite Music Theater Singers And Acoustic Measures Of Voice Production Methods: A Pedagogic Analysis, Leigh Usilton Jan 2015

The Relationship Between Kinesthetic Perceptions Of Elite Music Theater Singers And Acoustic Measures Of Voice Production Methods: A Pedagogic Analysis, Leigh Usilton

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study relates acoustic changes that occur during female belt voice, mix voice, and legit voice to the self-reported physical sensations of elite music theater (MT) singers for the purposes of developing further pedagogic language to convey imagery and sensation to students of MT singing.;Six professional female MT singers comfortable producing belt, mix, and legit styles of singing sang a series of C major and E-flat major scales on the vowels /alpha/, /ae/, /epsilon/, and /[special character omitted]/, followed by three brief excerpts from the modern MT repertoire. Both prior to and following the sung exercises, subjects described the three …


Classical And Jazz Influences In The Music Of Nikolai Kapustin: Piano Sonata No. 3, Op. 55, Yana Tyulkova Jan 2015

Classical And Jazz Influences In The Music Of Nikolai Kapustin: Piano Sonata No. 3, Op. 55, Yana Tyulkova

Graduate Theses, Dissertations, and Problem Reports (ETD)

The subject of this dissertation is the contemporary Russian composer and pianist Nikolai Kapustin. Being himself a virtuoso pianist, Kapustin has written a large repertoire for solo piano. During the last fifteen years, the popularity of Kapustin in the United States has grown enormously through performances, publications, presentations, and recordings. Kapustin's output has over 150 opus numbers in all major forms of Baroque, Classical and Romantic music, such as suite, invention, preludes and fugues, variations, sonata, concerto, and more.;Kapustin's style fuses the classical approach to form and the jazz approach to harmony and rhythm in a very unique way. His …


Detection And Location Of Faults In Wide Area Systems Based On Error-Dependent Communication Strategy, Preethi Priya Vallapu Jan 2015

Detection And Location Of Faults In Wide Area Systems Based On Error-Dependent Communication Strategy, Preethi Priya Vallapu

Graduate Theses, Dissertations, and Problem Reports (ETD)

Transmission system serves as a crucial link between generating stations and consumers. Early detection and accurate location of faults on transmission lines are essential to prevent the occurrence of blackouts. Also real time monitoring of power system states during faults will enhance the situational awareness for power system operators. Wide Area Measurement and Protection Systems (WAMPS) based on Phasor Measurement Unit (PMU) are a promising solution for dynamic real time monitoring and protection of power system.;This thesis deals with detection and location of faults on a transmission system based on synchrophasor technology. Performance of WAMPS is largely dependent on the …


Atlanticism In Visegrad: Understanding The Relationship Between Central Europe And The U.S. After 1989, Brian S. Valdivia Jan 2015

Atlanticism In Visegrad: Understanding The Relationship Between Central Europe And The U.S. After 1989, Brian S. Valdivia

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis seeks to explore the relationship of the countries of Poland, Hungary, the Czech Republic, and Slovakia (together known as the Visegrad Group or Visegrad 4 [V4]) with the US after the fall of communism, and how this relationship helped them to transform their political and economic systems. This study will primarily focus on the years between 1989-2000, as this was the period during which US-V4 relations were at their peak. After the conclusion of the Clinton presidency, US foreign policy refocused its priorities as the US saw Central Europe as finally part of the Atlantic world and therefore …


The Professional Quality Of Life And Resiliency In Mental Health Professionals Working With Suicide In Crisis Care, William Bradley Little Jan 2015

The Professional Quality Of Life And Resiliency In Mental Health Professionals Working With Suicide In Crisis Care, William Bradley Little

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study examined the professional quality of life (ProQOL) and resiliency among a sample of 85 active and licensed mental health professionals working in acute/crisis settings in the United States. Within the ProQOL construct exists the constructs of burnout, secondary-traumatic stress, and compassion satisfaction. It was hypothesized that impaired levels of resiliency, higher frequencies of contact (FOC) with clients admitted to care due to suicide, female gender, and fewer years of experience would be associated with increased burnout and secondary traumatic stress scores and decreased compassion satisfaction scores as measured by the Professional Quality of Life Scale Version 5. Multiple …


Suicidal Ideation, Attempts, And Associated Psychosocial Risk And Protective Factors In American Indian Youth And Young Adults, Karen Manzo Jan 2015

Suicidal Ideation, Attempts, And Associated Psychosocial Risk And Protective Factors In American Indian Youth And Young Adults, Karen Manzo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction. Research consistently shows that suicidal ideation and attempts are more prevalent among American Indian youth and young adults than youth and young adults in other racial/ethnic groups. Many of the associated psychosocial risk and protective factors are shared across racial/ethnic groups; however, for most of them, the prevalence is highest in American Indian youth. Research on the relation between suicide risk and culturally unique risk (e.g., childhood adversity, discrimination, parenting, unresolved grief, out-of-home placement) and protective factors (e.g., enculturation, cultural values, spirituality) in American Indian youth and young adults is limited. The goal of this research was to examine …


Legalized Racial Profiling And Arizona Sb1070: A Framing Effects Study, Agnieszka N. Marciniak Jan 2015

Legalized Racial Profiling And Arizona Sb1070: A Framing Effects Study, Agnieszka N. Marciniak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Immigration has become one of the most important topics on the agenda of federal and state governments. President Obama just passed his pro-immigration executive order allowing five million undocumented immigrants to gain legal work visas. Conversely, there are laws such as Arizona Law SB1070, passed by Governor Jan Brewer in 2010, opposing Obama's pro-immigration stance. In the case of Arizona Law SB1070, it is important to have a basic understanding of the stereotypical perceptions people have of immigrants if laws like these are going to be enforced. In this study, we experimentally manipulated a real-life scenario of an immigrant being …


Short Wave Infrared Imaging System For Night And Day Long Range Facial Recognition And Surveillance, Robert B. Martin Jan 2015

Short Wave Infrared Imaging System For Night And Day Long Range Facial Recognition And Surveillance, Robert B. Martin

Graduate Theses, Dissertations, and Problem Reports (ETD)

The capability to detect, observe, and positively identify people at a distance is important to numerous security and defense applications. Traditional solutions for human detection and observation include long-range visible imagers for daytime and thermal infrared imagers for night-time use. Positive identification, through computer face recognition, requires facial imagery that can be repeatably matched to a database of visible spectrum facial mug shots. Nighttime identification at large distances is not possible with visible imagers due to lack of light, or with thermal infrared imagers due to poor correlation with visible facial imagery. An active-SWIR imaging system was developed that is …


A Multi Agent System Design For Power Distribution Restoration Using Neural Networks, Mohamad Mashta Jan 2015

A Multi Agent System Design For Power Distribution Restoration Using Neural Networks, Mohamad Mashta

Graduate Theses, Dissertations, and Problem Reports (ETD)

The state of the art of power distribution systems is to demand a more accurate response. It also provides more reliability for fault location and restoration respectively. A multi-agent system design for power distribution has been developed using the change of current methodology to detect and locate any type of faults. Employing the artificial intelligence for restoration process is the most important contribution to this study. Since feed-forward neural networks are weight training based back propagation concept, radial basis neural networks showed more efficiency by using the minimum error method to optimize the decision. A Probabilistic radial basis Neural Network …


Becoming A Mindful Sport Psychology Consultant: Defining, Developing, And Integrating Mindfulness Into Practice, Michelle M. Mcalarnen Jan 2015

Becoming A Mindful Sport Psychology Consultant: Defining, Developing, And Integrating Mindfulness Into Practice, Michelle M. Mcalarnen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sport psychology consultation is a problem solving situation and process (Sears, Rudisill, & Mason-Sears, 2006) in which sport psychology consultants (SPCs) are interpersonal and content communicators. To date, research in applied sport psychology has not examined consultants from the perspective of consultants as communicators in problem solving situations. Additionally, it remains unclear how consultants' graduate education and applied training experience relates to certain communication skills, such as mindfulness, cognitive flexibility, and communication flexibility. Yet, these skills, and its influence on consultants, have garnered interest for further study in professional practice literature (Baer et al., 2008; Davis, 2013; Poczwardowski & Sherman, …


The Effects Of Partnership-Based Collaborative Consultation On Treatment Integrity, Increasing Skill Acquisition, And Reducing Problematic Behaviors, Michael Mendicino Jan 2015

The Effects Of Partnership-Based Collaborative Consultation On Treatment Integrity, Increasing Skill Acquisition, And Reducing Problematic Behaviors, Michael Mendicino

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to evaluate the impact of a partnership-based model of collaborative consultation on the acquisition and implementation integrity of Competent Learner Model and the subsequent impact on learner outcomes including the development of competent learner repertoires. Treatment integrity measures were collected to assess the impact on learner outcomes. The participants were one teacher and one student. A Multiple baseline across behaviors design was used. Measures used were the Partnership Assessment in Community-based Research (PAIR), and the Instructional Session Performance Checklist (ISPC). The results showed moderate and sustained levels of treatment integrity with mixed results for …


Persuasion, Police, And Public Safety: Message Framing, Compliance, And Perceptions Of Law Enforcement, Alexander L. Lancaster Jan 2015

Persuasion, Police, And Public Safety: Message Framing, Compliance, And Perceptions Of Law Enforcement, Alexander L. Lancaster

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the everyday interactions between law enforcement and the citizens of their communities, officers attempt to gain compliance verbally, before resorting to physical force, if necessary. This dissertation examined the use of persuasive verbal messages by law enforcement officers when encountering citizens. These messages were created to represent a progression of asking, telling, and making, to gain compliance from an individual.;The officers in this study were university police officers, because university police departments are charged with providing a safe learning environment on campus. Due to the visible, community oriented policing in which university police departments tend to engage, it is …


Sustainability Index Development For Manufacturing Industry, Hasan Habibul Latf Jan 2015

Sustainability Index Development For Manufacturing Industry, Hasan Habibul Latf

Graduate Theses, Dissertations, and Problem Reports (ETD)

Manufacturing industries are adopting new techniques and philosophies to address the acute shortage of non-renewable energy. Many of these manufacturing industries are focusing on achieving sustainability in every possible stage of their production, from raw material to the recycling of waste. Thus, the significance of using renewable energy, properly handling waste, and progressively conserving the environment is increasing day by day. In this research, the definition of sustainability is quite specific: being productive while making little to no impact on non-replenishable resources. The objective of the research is to determine the sustainability index of manufacturing plants. Since the topic has …


The Portrayal Of Protagonists With Communication Disorders In Contemporary Award-Winning Juvenile Fiction, Jane Lefevre Jan 2015

The Portrayal Of Protagonists With Communication Disorders In Contemporary Award-Winning Juvenile Fiction, Jane Lefevre

Graduate Theses, Dissertations, and Problem Reports (ETD)

Twenty-six contemporary North American award-winning intermediate children's and young adult fictional books were identified that contained twenty-seven protagonists with communication disorders (CD). These books were evaluated using an adaptation of the Dyches & Prater (2000) Rating Scale for Quality Characterizations of Individuals with Disabilities in Children's Literature. Each guideline is discussed in detail while examining the quality of portrayed characterizations and literary elements in the eligible literature. The types of CDs depicted were language, speech and hearing disorders. No protagonists with central auditory processing disorders were found. Almost half of the protagonists had language disorders, making it the most commonly …


Differences In Psychosexual Development Between Child And Peer Male Juvenile Sex Offenders, Colleen M. Lillard Jan 2015

Differences In Psychosexual Development Between Child And Peer Male Juvenile Sex Offenders, Colleen M. Lillard

Graduate Theses, Dissertations, and Problem Reports (ETD)

Juvenile sex offenders account for approximately 50% of child sex abuse cases and 20% of sexual assault cases in the United States. Researchers, in an attempt to better understand the etiology of this behavior, have examined typologies of juvenile sex offenders, including victim-age. Much of the research has compared juveniles who offended against children versus juveniles who have offended against peers/adults. Recent research has also compared these two groups with those juvenile sex offenders who offended against both children and peers (i.e., mixed offenders). Using data from psychological evaluations and the Multiphasic Sex Inventory- II (MSI-II; Nichols & Molinder, 2010), …


Ethnic Diplomacy: Race, The United States, And Mexico During World War Ii, Jordan Lieser Jan 2015

Ethnic Diplomacy: Race, The United States, And Mexico During World War Ii, Jordan Lieser

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation begins by framing the overall relationship between the United States and Mexico during World War II and recognizes the significant economic role Mexico played in the U.S. wartime industrialization. With this framework in place, the emphasis of this research then turns to how Mexico pressured the United States government into addressing the racial prejudice which existed within the United States against what was perceived as a unified Latin American ethnic group. Thanks to the increased importance of Mexico, multiple parts of the United States government including the State Department, the Office of the Coordinator of Inter-American Affairs, the …


Using Storytelling As A Teaching Strategy To Increase Student Engagement In Stem Classes, Toni Morris Jan 2015

Using Storytelling As A Teaching Strategy To Increase Student Engagement In Stem Classes, Toni Morris

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study investigated whether or not the storytelling strategy could be used to increase student engagement and learning among non-STEM/STEAM majors participating in STEM/STEAM courses required by their programs of study. Specifically, it examined whether or not using storytelling to teach health science content to Early Childhood Development and Elementary Education students contributed to higher levels of student engagement, retention of content knowledge, self-reported preparedness to teach the content as future teachers, and ratings of teacher effectiveness. This study employed a QUAN-qual design. A true experimental design was used for the quantitative portion of the study while semi-structured group interviews …


A Safety Support System For Children's Antiloss, Sai Ram Nellutla Jan 2015

A Safety Support System For Children's Antiloss, Sai Ram Nellutla

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the recent past, crimes against children and the number of the missing children have been stayed at high. It is a tragic disaster for a family if their child is missing. Feeling safe about their children is very important for the parents. Therefore, there is an urgent requirement for safety support systems to prevent crimes against children and for anti-loss, particularly when the children are on their own, such as on the ways to and from schools. Thanks to the highly development of telecommunication and mobile technologies, preventive devices such as child ID kits, family trackers have come to …


The Online Lamodel User's & Training Manual Development & Testing, Christopher R. Newman Jan 2015

The Online Lamodel User's & Training Manual Development & Testing, Christopher R. Newman

Graduate Theses, Dissertations, and Problem Reports (ETD)

In order to better inform and train industry professionals, as well as engineering students and new users, an electronic user's manual and comprehensive online training course for LaModel has been developed in an open online learning environment. The online user's manual provides widespread access to detailed information on the installation, proper use, and troubleshooting procedures through a combination of: written documentation, voiced-over and captioned software simulations and slide presentations, and relevant academic articles. Some of the online LaModel material has also been organized into a set of progressive, self-paced training modules using a number of the slide presentations and software …


Analgesic And Anti-Inflammatory Effects Of Monoacylglycerol Lipase Inhibition In Mice Subjected To Collagen-Induced Arthritis, Sara R. Nass Jan 2015

Analgesic And Anti-Inflammatory Effects Of Monoacylglycerol Lipase Inhibition In Mice Subjected To Collagen-Induced Arthritis, Sara R. Nass

Graduate Theses, Dissertations, and Problem Reports (ETD)

Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory joint disease, affecting approximately 1% of the world population. This autoimmune disease is characterized by pain, stiffness, swelling, and breakdown of cartilage in synovial joints. Current RA analgesic treatments (i.e., pain reducing drugs) are ineffective or induce negative side effects, and so there are many concerted efforts to discover new RA treatments. Cannabinoids have analgesic and anti-inflammatory properties; however, the challenge remains to harness the medical potential of cannabinoids without inducing negative psychoactive effects (e.g., cognitive deficits, emotional disruption, and abuse potential). An alternative approach focuses on the endogenously produced cannabinoids …