Digital Commons Network^™

The Impact Of Treatment Dosage On Cognitive-Linguistic Outcomes Of Patients With Aphasia: An Investigation Of Three Service Delivery Models, Adele J. Derendinger

Graduate Student Theses, Dissertations, & Professional Papers

This study addresses the gap in literature by directly comparing the effectiveness of Intensive Comprehensive Aphasia Programs (ICAPs) and modified ICAPs (mICAPs) to usual care service delivery models for people with aphasia. Through a prospective study design, cognitive-linguistic function change scores across different service delivery models were examined. The findings reveal significant within-group improvements in cognitive-linguistic function for participants in ICAPs, with some improvement seen in mICAPs and usual care conditions. Intensive models demonstrated greater improvement compared to non-intensive usual care models, particularly evident in the Western Aphasia Battery – Revised and the Boston Naming Test – Second Edition. …

The Effects Of Beaver Dam Anaolgs On Linked Aquatic-Terrestrial Communities In Western Headwater Streams, Michelle Elyse Fillion, Benjamin P. Colman, Rachel L. Malison

Graduate Student Theses, Dissertations, & Professional Papers

In response to stream degradation resulting from the near eradication of American Beavers (Castor canadensis), managers of freshwater systems have turned to using beaver dam analogs (BDAs) as one means of restoring waterways from stream and riparian degradation. Though BDAs have been shown to restore physical traits of riparian areas, their influence on macroinvertebrates and linked aquatic-terrestrial systems is not well understood. To examine how BDAs influence aquatic habitats, macroinvertebrate communities, and riparian insectivores, we compared unrestored reference stream segments to BDA-restored segments with 7-14 BDAs in three western Montana headwater streams. We collected physical stream measurements and quantitative samples …

Structural And Functional Analysis Of Glun2a-Selective Negative Allosteric Modulators, James Scott Lotti

Graduate Student Theses, Dissertations, & Professional Papers

NMDA-type ionotropic glutamate receptors are widely expressed throughout the central nervous system and are critically involved in many healthy neuronal processes. Dysregulation of NMDA receptor activity underlies many disease pathologies, several of which benefit from treatment with antagonists, such as the FDA-approved channel blockers ketamine, memantine, and adamantine. NMDA receptors are composed of two glycine-binding GluN1 subunits and two glutamate-binding GluN2A-D subunits. The GluN2A-D subunits display distinct regional and developmental expression patterns, enabling region- or cell type-specific targeting of NMDA receptors through subunit-selective pharmacological intervention. There are several classes of subunit-selective negative allosteric NMDA receptor modulators, but the mechanisms of …

Perspectives On Using Pharmacogenomics To Guide Tobacco Cessation: Survey Results From An American Indian Community, Daniela Mariana Wall

Graduate Student Theses, Dissertations, & Professional Papers

Pharmacogenomics research has predominantly focused on populations of European ancestry, limiting the application for diverse populations such as American Indian and Alaska Native (AIAN) communities. Our community-centric study aims to understand perspectives of utilizing pharmacogenomics to guide tobacco cessation in an AIAN community using a survey with qualitative and quantitative components. We assessed participant (n=273) tobacco usage and cessation history, pharmacogenomics knowledge, and perceptions of utilizing pharmacogenomics in the context of tobacco cessation. We found that the majority of participants (92%) were aware of risks associated with tobacco usage and believe it to be a problem within their community (76%). …

Understanding Cellular Dynamics: Investigating A Yeast-Two Hybrid Protein-Protein Interaction, Riok3:Cse1l; Also By Investigating Trogocytosis Of Cd4+ T Cells From Rhog-/- Mice, Brittnee N. Crane

Graduate Student Theses, Dissertations, & Professional Papers

Rift Valley fever virus (RVFV) is a negative-sense virus that was first described in 1930 when it was isolated from sheep during an outbreak. In the last 25 years there has been a spread in the geographical range into the Middle East. The most susceptible animals are cattle, goats, sheep, and camels. The most overt symptom of livestock infection is that infected pregnant animals experience spontaneous abortion. Humans are susceptible as well and symptoms range from mild febrile illness to liver necrosis, blindness, hemorrhagic fever, and death. An important player in the cellular innate response to RVFV infections is the …

Temporal And Spatial Connectivity And The Impacts Of Hydropower In The Magdalena River Basin, Colombia, Serena Lynn Butler

Graduate Student Theses, Dissertations, & Professional Papers

Tropical regions hold untapped hydropower potential, but dam construction often adversely impacts multiple dimensions of connectivity in river systems, rigorous evaluation of which is often lacking. This study investigates temporal and spatial dimensions of longitudinal and lateral connectivity in the Magdalena River Basin, Colombia, a region with ongoing and planned hydropower projects. Limited in-situ monitoring data is a common challenge in tropical rivers. To address this, we utilized satellite imagery from Landsat (via Google Earth Engine) and Surface Water and Ocean Topography (SWOT) data. We examined alterations in the flow regime over time and relative to dam construction. We also …

Turbulence Resistant Schools: A Qualitative Phenomenological Study Of Educational Leadership In Central And Eastern Europe, Sofia Reis

Graduate Student Theses, Dissertations, & Professional Papers

The expanding complexity and increasing disruptions of our world affects schools. During both stable and unstable times, successful educational leaders support their schools’ ability to accomplish their core mission: student learning and development. Using a qualitative approach, this research explored experiences of educational leaders who established schools in Central and Eastern Europe during the post-Soviet era and continue leading them to this day. The central question was: What is the lived experience of successful assertive educational leaders as they navigate extreme turbulence? In this study, leadership is understood as a collegial activity determined by the context where it is embedded, …

Resilience, Adaptability, And Transformation: School Principal’S Response To Critical Events, Justine Jean Alberts

Graduate Student Theses, Dissertations, & Professional Papers

School principals face critical events as part of their professional roles. These critical events can profoundly impact their ability to lead, which is why this phenomenological study explored the central question, how do principals experience critical events that include perceived trauma? Using Moustakas’ (1994) process of transcendental phenomenological analysis, this research investigated the multifaceted emotional, professional, and personal responses of these educational leaders, revealing the complexities and consequences of their experiences. Semistructured interviews with fourteen current and former principals provided rich, in-depth qualitative data that captured the essence of their experiences. Findings indicated that principals often transition from their day-to-day …

Evaluating Early-Life Characteristics And Responses Of Native Plant Materials For Dryland Restoration, Sophia N. Lasche

Graduate Student Theses, Dissertations, & Professional Papers

Globally, many drylands are in need of restoration due to anthropogenic land use changes, climate change-related biodiversity loss, and broad scale degradation. Within this degradation framework, many perennial grass species and populations have been lost from drylands. A common method of restoring vital perennial grass populations is through seed-based restoration. Using seed-based restoration, or the act of adding desirable seed to a system to restore plant populations, requires a depth of knowledge on species level responses, as well as seed sources within those species. My research examines three workhorse perennial grass species and associated seed sources for dryland restoration, especially …

Puerto Rican Haplogroup Distribution: A Taíno History, Paige Mackenzie Williams

Graduate Student Theses, Dissertations, & Professional Papers

The extent to which Puerto Rico’s indigenous communities resisted, survived, and were transformed by colonization is unclear despite extensive ethnohistorical research. Historical claims of extinction are attributed to colonial census information but are strongly opposed by islanders who claim Indigenous Taíno ancestry (Nieves-Colón et al. 2019). Ethnic composition of Puerto Ricans is primarily European, African, and Indigenous and these compositions reflect migrations and admixture. Mitochondrial DNA (mtDNA) is of vast importance, as it permits tracing of the maternal line through a common female ancestor. In this, investigation of Indigenous haplogroup frequencies and their importance and relevance in Puerto Rican genetic …

The Influence Of Intensive Treatment In A Cohort Model On Psychosocial Well-Being Of Patients With Aphasia: An Investigation Of Patients’ Quality Of Life Across Three Service Delivery Models, Helena Riley

Graduate Student Theses, Dissertations, & Professional Papers

Aphasia, a common communication disorder following a stroke, significantly impacts psychosocial wellbeing and quality of life. Despite advancements in rehabilitation frameworks, traditional impairment-based interventions prevail, leaving gaps in addressing holistic needs. This study aims to compare patient-reported outcome measures (PROMs) between intensive comprehensive aphasia programs (ICAP), modified ICAPs (mICAPs) and individual usual care (UC) service delivery models for aphasia intervention. Eighteen participants with aphasia were broadly recruited for this study. Each completed a series of PROMs pre-and post-treatment examining psychosocial wellbeing, communicative participation, and health related quality of life. Results indicate that intensive programs show potential for greater gains in …

A Closer Look At Denali’S Alpine Wildlife: Assessing The Influences Of Climate And Vegetation Changes On Species In Alaska, Jennifer Lynn Wall

Graduate Student Theses, Dissertations, & Professional Papers

Climate change is amplified in polar regions and could have considerable consequences for biodiversity. Arctic and boreal regions, in particular, have warmed more than double the global average and are experiencing increasing precipitation, thawing permafrost, shrinking snow seasons, and increasing shrub- and tree-line encroachment. These changes are suspected to influence key alpine biodiversity, including species such as collared pikas (Ochotona collaris), hoary marmots (Marmota caligata), and Arctic ground squirrels (Urocitellus parryii). But, we have limited understanding of whether this is true and, if so, which factors drive distributional shifts in response to climate change. For this dissertation, I collected data …

From Creek To Ditch And Back Again: The History And Future Of Pattee Creek, Missoula, Montana, Carver Edward Butterfield

Graduate Student Theses, Dissertations, & Professional Papers

Pattee Creek was once a free-flowing stream that meandered across the Missoula Valley, but has been channelized, piped, and degraded by logging, mining, agriculture, and urbanization. This thesis used a mixed-method approach to examine the impact of human activities on the Pattee Creek watershed. Beginning with a historical overview, the story of how the creek has been utilized and why it was buried was told. An analysis of historical photos from 1937 to 2019 revealed drastic changes in the land cover of the watershed and the channel of lower Pattee Creek. Developed land increased dramatically, while open land decreased and …

Wildfires Are Burning Less Frequently And More Severely Than Historically In The Western Us: A Novel Approach To Calculating Fire-Regime Departures, Jeffrey Ryan Chandler

Graduate Student Theses, Dissertations, & Professional Papers

Changing climate, vegetation, and fire exclusion are altering and homogenizing fire-regime attributes compared to historic conditions. Fire-regime changes are commonly quantified using departure metrics, which are often based on measures of central tendency (i.e. changes in the mean). These metrics can mischaracterize complex changes to the distributional characteristics of fire-regime attributes. Here we develop a fire-regime departure metric that quantifies nonparametric distributional changes to fire-regime attributes over time. We use this metric to compare fire frequency and severity between historical (~1600-1880) and contemporary (1880- 2021) time periods in western US forests. Our analysis revealed that 89% of Western US forests …

Swimming Through Time: Ancient Dna Analysis Of Salmonid Remains At Housepit 54, Bridge River, British Columbia, Canada, Kara K. Fox

Graduate Student Theses, Dissertations, & Professional Papers

The application of ancient DNA (aDNA) analysis on archaeological faunal remains has proven successful in a variety of studies that have resulted in species identification and subsistence use at ancient village sites. Fisher-hunter-gatherer societies of the Pacific Northwest have depended heavily on seasonal salmon runs as a primary staple for foodstuffs and winter storage essentials. Determining which salmonid species were chosen provides a better understanding of ancient socio-economic strategies that impact food procurement and varying preferences of food items that can lead to resource access limitations. Ultimately, this thesis is a preliminary research project to establish the groundwork for successfully …

Gaba Transporter Loss-Of-Function Mutations In Pediatric Epilepsy: Neural Mechanisms And A Novel Fatty Acid Based Therapeutic Approach, Alessandra G. Jester

Graduate Student Theses, Dissertations, & Professional Papers

An increasing number of spontaneous mutations in the GABA transporter gene SLC6A1 (GAT-1) have been associated with pediatric epilepsy and neurodevelopmental disorders. The molecular mechanisms and impact of mutations on GABA homeostasis and neuronal circuit function are poorly understood. Furthermore, there are currently no validated therapeutic approaches to treat patients. A de novo mutation (S295L) in the GABA transporter gene SLC6A1 that was identified in a pediatric patient was introduced into a human cDNA construct, and mutant and wild-type transporters were expressed and studied in Xenopus oocytes by voltage clamp and radiolabeled GABA flux measurement. In addition, the effect of …

Sequence Similarity Search Optimization: Prefiltering Strategies And Exact Matching Techniques For Biological Sequence Data, Tim Anderson

Graduate Student Theses, Dissertations, & Professional Papers

Sequence similarity search is one of the most important tasks in the field of bioinformatics. The identification of regions of similarity between one protein or DNA sequence and a separate collection of sequences or models of sequence families has wide-ranging applications. These range from mapping of RNA sequence reads to a given genome to the annotation of gene-encoding regions and the reconstruction of evolutionary relationships of species. As genetic sequencing technologies have improved over the last few decades, the size of genetic sequence databases has grown exponentially. With this growth of sequence databases, more efficient algorithmic approaches are needed to …

Leaving Them In Stitches: Novel Methods For Splice-Aware Sequence Annotation, Alexander Nord

Graduate Student Theses, Dissertations, & Professional Papers

Pre-mRNA intron splicing is essential to the production of many eukaryotic proteins, but it is relatively uncommon for sequence analysis tools to account for this process in their methods. In this dissertation I present three tools for biological sequence analysis, demonstrating the benefits that they derive from their explicit awareness of intron splicing. First, I present Mirage2, an updated implementation of the Mirage multiple sequence alignment program, which produces alignments of protein isoforms according to spliced genome mapping coordinates. I then present Diviner, which synthesizes the output data produced by Mirage2 to locate novel coding regions on eukaryotic …

Comprehensive Case Report Umfc#140, Marymargaret C. Pratt

Graduate Student Theses, Dissertations, & Professional Papers

University of Montana Forensic Collections (UMFC) Case #140 was observed and recorded fall 2024. The information included are a complete biological profile, any taphonomic features or pathological conditions present, and a literature review on forensic odontology due to the severe nature of the teeth. This individual is consistent with a 5'2"-5'6" adult male ranging between the ages of 35-50 of ambiguous population affinity. Evidence of osteoarthritis and bone spurs are present along the vertebral spine, clavicle, and articulation points throughout the post-cranial skeleton. There is severe dental attrition found along the buccal view of the maxillary and mandibular molars. The …

Flyway Bottlenecks: Migratory Waterbirds Confront Diminishing Wetland Networks In Western North America, J. Patrick Donnelly

Graduate Student Theses, Dissertations, & Professional Papers

In the arid and semi-arid western U.S., migratory waterbirds (e.g., shorebirds, wading birds, and waterfowl) rely on wetland landscapes that function as nodes in broader continental habitat networks (e.g., flyways). Here, I integrate citizen science and GPS animal tracking technologies with satellite imagery and cloud computing to quantify the effects of climate and land use change on wetland ecosystems that sustain migratory waterbirds in the western U.S. Four decades of wetland surface water hydrology were first reconstructed from over 150,000 individual satellite images covering 3.1 million ha to track monthly changes in the extent and duration of wetland inundation. Results …

Moose Abundance And Calf:Cow Ratios On The Blackfeet Indian Reservation And Glacier National Park, Landon Joel Magee

Graduate Student Theses, Dissertations, & Professional Papers

Many moose (Alces alces; Sikihtsisoo) populations across North America, especially along their southern range, are declining due to factors such as climate change, parasites and disease, predation, habitat loss and degradation, and overharvest. These declines highlight broader ecological concerns, as moose play a critical role as prey within their ecosystems. Despite their importance, data on crucial demographic parameters like abundance and age ratios are sparse for moose, complicating management efforts. Conventional monitoring methods, including radio-collaring, harvest data, public surveys, and aerial surveys, face significant logistical and financial challenges, and often fail to provide a comprehensive understanding of …

A Narrative Map Of Fort Missoula: Silence, Stillness And Death In Living Cultural Memory, Daniel A. Goldhamer

Graduate Student Theses, Dissertations, & Professional Papers

Fort Missoula is a rare site of history, memory, and narrative. This project seeks to trace the complex web of identities and relationalities at the Fort through a narrative map: a method that combines site-based ethnography and qualitative storytelling relying on first-person perspective. This methodological framework reveals that Fort Missoula’s distinct character lies in its role as a living archive of cultural memory, accessible through the past, present, and future narratives of its places and spaces. Engaging with the theories of Foucault (1972), de Certeau (1984), and Low (2017), the narrative map of Fort Missoula is a work that investigates …

Traditional Chinese Medicine And The Argument For Future Application In The United States, Kylie Nicole Frohlich

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Evaluation Of Silk Fibroin And Hylauronic Acid As Otic Drug Delivery System Additives; Investigation Of Silk Fibroins Responses To Enviromental Stimulii, Kolton Charles Sandau

Graduate Student Theses, Dissertations, & Professional Papers

The Serban lab has previously developed and reported on a single application drug delivery system for the treatment of otitis externa. Otitis externa also known as outer ear infections is a very common ailment that impacts large portions of both human and domestic animal populations. Typical treatment for otitis externa typically requires an extended dosing regimen over several days that is inconvenient and can lead to poor clinical outcomes due to poor patient compliance. Our delivery system employs a thixotropic gel to deliver a steady dose of medication over the duration of the infection.

Here we evaluated the reproducibility and …

Density Anomaly Leads To Rift Initiation: Quantifying Active Rifting And Comparison To The East African Rift Zone, Chloe Boucher

Graduate Student Theses, Dissertations, & Professional Papers

Active rifting, elastic failure in the lithosphere from rising density anomalies in the mantle, is fundamental to the Wilson Cycle which describes the cycle of tectonic plates. Active rift zones are common in the oceanic lithosphere but are less common in the thicker continental lithosphere. The current largest active continental rift zone is the East African Rift Zone (EARZ). Although active rifting is fundamental to plate tectonic theory, the mechanics and parameters needed for a density anomaly to initiate a rift have not been undertaken. This model aims to solve the problem of a density anomaly initiating a continental rift …

A Tale Of Two Working Landscapes, Sage C. Sutcliffe

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Where The Framework Ends: Equity Considerations And Limitations During Agency River Permit Allocation Decision Making Processes, Kelsey Ellen Phillips

Graduate Student Theses, Dissertations, & Professional Papers

River recreation in the U.S. increased dramatically in the 1970s as boating technology and recreational skill level shifted, thus a number of federally- and state-managed river areas instituted use limits over the years to prevent the environmental and social impacts perceived to have stemmed from increased use. These river managers were then faced with the task of allocating this use between private and commercial users (allotment) and within these groups (rationing), complicated by the fact that members of the public perceive equity differently. Early recreation use allocation research explored how different rationing techniques favor different groups, for example those with …

Navigating Conservation Planning For A Small Land Trust, Megan Elise Euclide

Graduate Student Theses, Dissertations, & Professional Papers

In the face of ongoing biodiversity loss and limited resources, the urgency for effective conservation strategies and planning is vital. This paper explains key components and principles of effective conservation planning, applicable across various temporal and spatial scales, institutional contexts, and motivations for conservation. These components encompass framing the conservation planning problem, devising solutions, and implementing strategies. Effective planning efforts are supported by principles such as formulating a clear purpose statement, establishing objectives, addressing critical uncertainties, integrating knowledge into decision-making processes, and embracing flexibility and iteration. Incorporating these elements into conservation planning enhances decision-makers' ability to make informed decisions, ultimately …

The Other Identity Politics: Political Turning Points And Political Identity Development In College-Going Emerging Adults, Kaetlyn Jeanette Cordingley

Graduate Student Theses, Dissertations, & Professional Papers

Emerging adulthood is a critical developmental period, especially for identity– the development of our sense of who we are internally and relative to others. This research sought to investigate one understudied aspect of identity development: political identity. Five questions guided this research: first, is political identity related to broader identity development? Second, does political identity development differ based on political ideology (liberal, moderate, conservative)? Third, do individuals’ self-identified political turning point events differ based on political ideology? Fourth, how is political identity development related to political turning point narratives? Fifth, how does meaning making interact with political identity development and …

Zooming In On A Snapshot Of Care: Adapting The Index Of Care For Historical And Modern Individuals In The Terry Collection, Felicia Robyn Sparozic

Graduate Student Theses, Dissertations, & Professional Papers

This dissertation adapts the Index of Care (IOC), traditionally focused on prehistoric contexts, to historical (1840-1950) and modern (post-1950) individuals from the Smithsonian’s Terry Collection, to account for those individuals with extensive records. By introducing sister methodologies for both historical and modern contexts, this research bridges the methodological gap in care analysis, enhancing the original IOC with contextual environmental variables and, for modern individuals, DNA analysis.

The study utilizes a selected cohort from the Terry Collection, emphasizing the investigation of caregiving practices across different sexes and ancestral backgrounds. Contrary to initial hypotheses predicting sex-based differences in care provision, findings show …