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Defining Postmortem Changes In Western Montana: The Effects Of Climate And Environment On The Rate And Sequence Of Decomposition Using Pig (Sus Scrofa) Cadavers, Jessica R. Spencer
Defining Postmortem Changes In Western Montana: The Effects Of Climate And Environment On The Rate And Sequence Of Decomposition Using Pig (Sus Scrofa) Cadavers, Jessica R. Spencer
Graduate Student Theses, Dissertations, & Professional Papers
The rate and sequence of human decomposition permits forensic anthropologists to estimate time since death for remains from the forensic context. Preliminary research conducted in western Montana indicates that decomposition does not follow the patterns found in other geographic locations. The purpose of this study is to better define western Montana’s unique environmental factors that affect the rate and pattern of decomposition by documenting changes in mature pigs (Sus scrofa) employed as human proxies. The pigs were deposited during the cold months of October and December and analyzed by comparing the rate and sequence of decomposition with climatological and environmental …
The Lived Experience Of American Indian Teen Parents From A Northern Plains Tribe, Ann Marie Douglas
The Lived Experience Of American Indian Teen Parents From A Northern Plains Tribe, Ann Marie Douglas
Graduate Student Theses, Dissertations, & Professional Papers
Although there is extensive research on the outcomes of teen mothers and their children, there is little research to date on how teen parents, especially American Indian teen parents, are functioning in their new role. This is alarming as the rate of births to American Indian teens is far greater than the same-aged Non-Hispanic White population. This study examined the lived experiences of teen parents currently living on a Northern Plains Indian Reservation. Seven participants were interviewed using a phenomenological method. Interviews were analyzed using NVivo and Giorgi’s method. The themes that emerged were traditional roles (child role, parent role, …
A Preliminary Analysis Of Saw Mark Degeneration In Bone Due To The Application Of Hydrated Calcium Oxide, Heidi Lynne Johnson
A Preliminary Analysis Of Saw Mark Degeneration In Bone Due To The Application Of Hydrated Calcium Oxide, Heidi Lynne Johnson
Graduate Student Theses, Dissertations, & Professional Papers
The use of calcium oxide (lime) in both agricultural and burial customs has been seen since the Iron Age. Due to this usage, the myth stating that the application of this chemical will expedite the complete destruction of human remains developed. This myth, in conjunction to historical and contemporary instances of its usage related to criminal activities has demonstrated a need to better understand the interactions of this chemical with bony tissue, particularly as it relates to saw cutmarks. Using pig elements as proxies for human remains, this research aims to systematically examine the degenerative effects resulting from the application …
Defining Postmortem Changes In Western Montana: A Longitudinal Study Of The Rate And Sequence Of Surface And Burial Decomposition, Tory Nicole Huey
Defining Postmortem Changes In Western Montana: A Longitudinal Study Of The Rate And Sequence Of Surface And Burial Decomposition, Tory Nicole Huey
Graduate Student Theses, Dissertations, & Professional Papers
Estimating time since death is difficult because of the multitude of factors that can alter postmortem change. Initial research conducted in western Montana indicates that decomposition does not follow the patterns found in other geographic locations. The purpose of this study is to better define how western Montana’s unique environmental factors affect the rate and pattern of decomposition of surface remains and buried remains. In May 2012 one mature pig (Sus scrofa) was placed on the surface and a second pig was buried. Throughout a nine-month period the following variables were monitored for the surface pig: rate and pattern of …
Effect Of Cover On Small Mammal Abundance And Movement Through Wildlife Underpasses, Hayley R. Connolly-Newman
Effect Of Cover On Small Mammal Abundance And Movement Through Wildlife Underpasses, Hayley R. Connolly-Newman
Graduate Student Theses, Dissertations, & Professional Papers
Crossing structures enable wildlife to safely cross highways by physically separating wildlife and vehicles. Most wildlife underpasses and overpasses are designed to accommodate a wide variety of species. Their suitability for individual species, however, varies by location (surrounding habitat), structure type (e.g. underpass or overpass), and dimensions (height, width, length). For some taxa, the habitat immediately adjacent to and inside an underpass or on top of an overpass is critical. For instance, small mammals, reptiles, amphibians and many invertebrates may avoid open areas because they require cover (e.g., live vegetation, tree stumps, branches, or rocks) to reduce predation risk and …
Queer Panic In Native American Literature, Theodore Cecil Decelles
Queer Panic In Native American Literature, Theodore Cecil Decelles
Graduate Student Theses, Dissertations, & Professional Papers
Indigenous American sexual minorities and alternatively gendered voices went underground due to Eurowestern sexual colonization from the time of the conquistador invasions of the early 16th century to the political campaigns of cultural homogenization of the mid-20th century. A cultural distortion still exists in the postcolonial era. In the past many North American indigenous nations had culturally specific sexualities and genders that reflected the cultural heterogeneity of the Americas. Today cultural assimilation negatively affects queer Native Americans, and culturally imported attitudes of homophobia are reflected in Native American literature. An interdisciplinary approach must be used to study the cultural distortion …
Indoor Coarse Particulate Matter: Evaluating Exposures And Health Effects In Asthmatic Children, Marcy Lynn Mcnamara
Indoor Coarse Particulate Matter: Evaluating Exposures And Health Effects In Asthmatic Children, Marcy Lynn Mcnamara
Graduate Student Theses, Dissertations, & Professional Papers
The primary aim of the ARTIS study (Asthma Randomized Trial of Indoor Wood Smoke) is to improve the quality of life of asthmatic children living in wood stove homes by reducing in-home fine particulate matter (PM2.5). In the original project, characterizing exposure to the coarse fraction of particulate matter (consisting of particles <10 μm and >2.5 μm; PMc) was not proposed. The coarse fraction has been shown to elicit increased pulmonary inflammation compared to PM2.5. This may be due to biogenic constituents of PMc such as endotoxin, a component of the cell wall of Gram-negative bacteria. Scientific interest in the coarse fraction is …
Evaluating And Role Of Standards And Guidelines In National Forest Planning, Emily E. Schembra
Evaluating And Role Of Standards And Guidelines In National Forest Planning, Emily E. Schembra
Graduate Student Theses, Dissertations, & Professional Papers
There is longstanding conflict related to planning standards and guidelines (S & Gs) used by the U.S. Forest Service to guide and constrain National Forest System land management. The role these prescriptions have played in the past in forest management, and the role they ought to play in the future, is often disputed. However, the National Forest Management Act (NFMA) and the new 2012 NFMA planning regulations require S & Gs, so they must be included in forest plans in the future. The goal of this research was to provide a common understanding of how planning S & Gs were …
Biological Effects Of Trogocytosis On Cd4+ T Lymphocytes, Douglas Grant Osborne
Biological Effects Of Trogocytosis On Cd4+ T Lymphocytes, Douglas Grant Osborne
Graduate Student Theses, Dissertations, & Professional Papers
Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological synapse. The mechanism and biological significance of this process, termed trogocytosis, is still unclear. In this thesis I examined the impact that trogocytosis has on the individual T cell after capturing molecules from the antigen presenting cell. I employed murine fibroblast cell lines expressing an I-Ek molecule loaded with a covalently attached antigenic peptide (moth cytochrome C 88-103) and with or without …
A Molecular Genetic Investigation Of The Regulation Of Outer Surface Protein C In Borrelia Burgdorferi: Identification And Characterization Of The Novel Regulatory Protein Bbd18, Beth Hayes
Graduate Student Theses, Dissertations, & Professional Papers
Lyme disease, caused by Borrelia burgdorferi, is the most prevalent arthropod-borne disease in the U.S. In nature, B. burgdorferi is maintained in an enzootic cycle between Ixodes ticks and mammalian hosts. In order to cause infection in mammals, B. burgdorferi spirochetes within a feeding tick sense environmental changes and subsequently alter their gene expression and protein profiles. As part of this adaptation, spirochetes within the tick midgut downregulate outer surface protein (Osp) A and upregulate OspC. Although OspC is an essential B. burgdorferi virulence factor needed for early mammalian infection, it is also a target for the mammalian acquired immune …
Nest Site Characteristics Of Lewis’S Woodpecker (Melanerpes Lewis) In Riparian Systems Of Western Montana, Megan Fylling
Nest Site Characteristics Of Lewis’S Woodpecker (Melanerpes Lewis) In Riparian Systems Of Western Montana, Megan Fylling
Graduate Student Theses, Dissertations, & Professional Papers
The Lewis’s Woodpecker (Melanerpes lewis) is known to breed in ponderosa pine, cottonwood riparian, aspen, and burned conifer forest types, but is declining in much of its range throughout the U.S. and is listed as a Level II Species of Concern in Montana. In western Montana, Lewis’s Woodpeckers commonly breed in riparian bottomlands, but information on characteristics of their preferred nesting habitat within these areas is lacking. I studied nesting habitat use by Lewis’s Woodpeckers in two important breeding areas in cottonwood-dominated riparian forest along the Clark Fork and Bitterroot rivers in western Montana. I found 55 nests during the …
Assessing Changes In Connectivity And Abundance Through Time For Fisher In The Southern Sierra Nevada, Jody Marlene Tucker
Assessing Changes In Connectivity And Abundance Through Time For Fisher In The Southern Sierra Nevada, Jody Marlene Tucker
Graduate Student Theses, Dissertations, & Professional Papers
Small populations are at increased risk of extinction due to their vulnerability to stochastic events. The population of fisher (Pekania pennanti, formerly Martes pennanti) in the southern Sierra Nevada Mountains of California is small and completely genetically isolated. My dissertation research investigates the timing and cause of this population's isolation, the degree of genetic subdivision within the population, the landscape features shaping gene flow, and the detection of population declines. I detected a 90% decline in effective population size and dated the time of decline to over a thousand years ago. Analyzing historical and contemporary genetic samples, I also found …
Changes In Litter Inputs And Decomposition In Headwater Streams During A Mountain Pine Beetle Infestation Of Whitebark Pine, Hilary Genevieve Eisen
Changes In Litter Inputs And Decomposition In Headwater Streams During A Mountain Pine Beetle Infestation Of Whitebark Pine, Hilary Genevieve Eisen
Graduate Student Theses, Dissertations, & Professional Papers
Headwater streams in forested landscapes are generally lacking in primary productivity and rely on allochthonous inputs to fuel secondary production. This close association with the forested landscape makes these streams sensitive to terrestrial disturbances. In the Greater Yellowstone Ecosystem (GYE) a climate change induced mountain pine beetle (Dendroctonus ponderosae, MPB) outbreak has been decimating whitebark pine (Picea albicaulis, WbP) forests over an extremely short time period. Among the possible implications of widespread WbP die-off, I predicted an increase in litter inputs to headwater streams and an increase in the quality (nitrogen content) of these litter inputs both of which would …
Characterizing Crown Struture Of Three Interior Northwest Conifer Species Using Terrestrial Laser Scanning, Jena Ferrarese
Characterizing Crown Struture Of Three Interior Northwest Conifer Species Using Terrestrial Laser Scanning, Jena Ferrarese
Graduate Student Theses, Dissertations, & Professional Papers
Emerging interests in wildland fire behavior and risk, bioenergy utilization, carbon sequestration, and wildlife conservation increasingly rely on accurate assessments of the amount and location of biomass within the dominant plants on the landscape, often at finer scales than traditional methods have provided. At the tree scale, current studies often distribute biomass uniformly through simple volumes (e.g., cones and cylinders). However, biomass is heterogeneous at a variety of scales from needle clusters to groups of trees. This thesis presents techniques for using terrestrial laser scanning data to define crown profiles and describe within-crown heterogeneity in Pseudotusga menziesii, Pinus ponderosa, and …
Evaluation Of A New Method For Large-Scale And Gene-Targeted Next Generation Dna Sequencing In Nonmodel Species, Ted Cosart
Graduate Student Theses, Dissertations, & Professional Papers
The efficient method called exon capture provides for sequencing genes genome-wide, targeting candidate genes, and sampling specific exons within genes. Although developed for model species with available whole genome sequences, the method can capture exons in nonmodel species using the genomic resources of a related model species. How close the relatives must be for effective exon capture is not known. The work herein demonstrates cross-taxa capture in ungulates, using the domestic cow genome as a reference. It also describes a computer program designed for collecting exon sequences for exon capture, allowing users to set per-gene and overall base pair (bp) …
P-Glycoprotein Transport In Pesticide Pharmacokinetics And Toxicity: Investigating A Link To Parkinson's Disease Risk, Sarah Elizabeth Lacher
P-Glycoprotein Transport In Pesticide Pharmacokinetics And Toxicity: Investigating A Link To Parkinson's Disease Risk, Sarah Elizabeth Lacher
Graduate Student Theses, Dissertations, & Professional Papers
Variation in the gene that encodes P-glycoprotein (P-gp), ABCB1, has been associated with Parkinson's disease risk. The aim of my research was to evaluate P-gp transport of pesticides that have been associated with Parkinson's disease as a mechanism for the pharmacogenomic association. To facilitate this aim, a combination of models was utilized to determine P-gp transport of the pesticides diazinon, dieldrin, endosulfan, maneb, MPP+, paraquat, and rotenone. Paraquat pharmacokinetics and brain accumulation were measured in both FVB wildtype and mdr1a(-/-)/1b(-/-) mice. P-gp deficient mice displayed no changes in paraquat brain accumulation, indicating that P-gp does not mediate paraquat disposition. I …
Modeling Connectivity In Landscape Genetics: Applications, Optimization And Assessing Uncertainty, Brian Kevin Hand
Modeling Connectivity In Landscape Genetics: Applications, Optimization And Assessing Uncertainty, Brian Kevin Hand
Graduate Student Theses, Dissertations, & Professional Papers
Connectivity modeling and corridor identification are an essential part of landscape genetics and important tools for the future of conservation biology. The previous decade has shown a steadily increasing interest and rise in publications in landscape genetics. This enthusiasm has led to advances in the methods and theoretical background of the field; however, there remain important, yet unresolved, challenges. Many of these are related to validation and uncertainty testing for resistance surfaces (hypotheses of connectivity). These fundamental issues need to be addressed before landscape genetics can gain the full recognition of a scientific discipline such as population genetics or landscape …
Working Memory Capacity Training And The Effect On Reading Comprehension, Numerical Reasoning, And Vocational Progress, David Evans Johnson
Working Memory Capacity Training And The Effect On Reading Comprehension, Numerical Reasoning, And Vocational Progress, David Evans Johnson
Graduate Student Theses, Dissertations, & Professional Papers
An individual’s working memory capacity determines their ability to control attention and discard irrelevant and interfering information in large environments. It also plays an important part in information processing of goal-relevant tasks. It is important to study the ways in which learners can augment the capacity of an important cognitive construct and investigate the potential benefits to improving attention, reasoning, and comprehension. In educational settings, students actively seek help from assistance programs that target academic performance. However, it is often the case that this assistance comes in the form of a targeted specific skill that is focused on a particular …
Community-Based Participatory Research To Partner With The Confederated Salish And Kootenai Tribes In Pharmacogenetics Research, Chelsea Theresa Morales
Community-Based Participatory Research To Partner With The Confederated Salish And Kootenai Tribes In Pharmacogenetics Research, Chelsea Theresa Morales
Graduate Student Theses, Dissertations, & Professional Papers
Pharmacogenetics research has advanced our knowledge of the genetic basis of individual drug responses. The aim of pharmacogenetics research is to provide opportunities for the development of strategies aimed at discovering clinically relevant gene-drug pairs. Further benefits stem from the translation of pharmacogenetics research into the clinic to identify patients who are at high risk of adverse drug events. However, American Indian and Alaska Native (AI/AN) populations have not benefited markedly from genetics-guided therapeutics. A key strategy in engaging AI/AN people in pharmacogenetics research has been the implementation of community-based participatory research (CBPR). CBPR is a qualitative research methodology in …
Investigation Of Craniofacial Morphological Variation At Sully (39sl4), Elizabeth Rose Agosto
Investigation Of Craniofacial Morphological Variation At Sully (39sl4), Elizabeth Rose Agosto
Graduate Student Theses, Dissertations, & Professional Papers
This study utilizes a theoretical framework of modern quantitative population genetics to identify factors contributing to the morphological variability between multiple, geographically distinct burial areas associated with the Sully village site (39LS4) in the Middle Missouri region of South Dakota. In particular three burial areas at Sully (A, D, and E) provide adequate samples for assessing intra-site variation. It has been a long-held belief that the observed morphological variability between burials areas is due to temporal sequencing; however, this explanation lacks hard craniometric and archaeological support. This study reassesses the assumption of temporal sequencing through the investigation of post marital …
Acceptance Of Wildlife Crossing Structures On Us Highway 93 Missoula, Montana, Jeremiah P. Purdum
Acceptance Of Wildlife Crossing Structures On Us Highway 93 Missoula, Montana, Jeremiah P. Purdum
Graduate Student Theses, Dissertations, & Professional Papers
Wildlife and humans have always interacted on the landscape. However, growing transportation infrastructure and its associated use are causing a large increase in direct and indirect effects on wildlife populations. Humans can also directly be affected, for example, through wildlife-vehicle collisions that impact human safety and lead to economic costs for individuals and society. In some cases transportation and wildlife agencies have implemented substantial mitigation measures along roadways in an attempt to reduce wildlife-vehicle collisions and to provide for safe crossing opportunities for wildlife. Wildlife-specific crossing structures are now increasingly considered in road construction. Reconstruction projects and a range of …
Climate As Assemblage: Imagining An Ecological Metaphysic, Andrea Rae Gammon
Climate As Assemblage: Imagining An Ecological Metaphysic, Andrea Rae Gammon
Graduate Student Theses, Dissertations, & Professional Papers
Human interventions have resulted in striking changes to the global climate. I work from the understanding of anthropogenic climate change as the product of 250 years of emissions brought about through industrialization and continued by our fossil fuel economies and lifestyles. The instrumentalism of such activities can be traced back to our modern metaphysic, where inanimate matter becomes object and falls away from ‘man,’ the knowing, active subject. In this thesis, I specifically address how this division of passive object from active subject pervades our understanding of climate and conditions the ethics of our human responses to climate change. I …
Nearing The End: Reef Building Corals And Bivalves In The Late Triassic And Comparing Corals And Bivalves Before And After The End-Triassic Mass Extinction Using A Taxonomic Database, Hannah Morgan Elliott Shepherd
Nearing The End: Reef Building Corals And Bivalves In The Late Triassic And Comparing Corals And Bivalves Before And After The End-Triassic Mass Extinction Using A Taxonomic Database, Hannah Morgan Elliott Shepherd
Graduate Student Theses, Dissertations, & Professional Papers
One of the most important tenants in geology is that the present is the key to the past, but it can also be said that the past is the key to the present. The five great extinction events are some of the key events that can help us to understand how changes in climate and sea chemistry can cause great changes in the ecology of our planet. Today the increase in atmospheric CO2 is causing ocean acidification, which has also been proposed as part of the system that caused the end-Triassic mass extinction. Ocean acidification can be greatly detrimental to …
Pristine Places And Passive People? Responses To Neoliberal Development And Maoist Conflict In Nepal's Northwest Himalayas, Catherine Lee Sanders
Pristine Places And Passive People? Responses To Neoliberal Development And Maoist Conflict In Nepal's Northwest Himalayas, Catherine Lee Sanders
Graduate Student Theses, Dissertations, & Professional Papers
In Humla District, Nepal, agro-pastoralists' confrontations with forces of change in the last generation have altered villagers' abilities to gain access to scarce resources. Development efforts and Nepal's recent armed conflict, in particular, introduced novel technologies and ideologies that affected Humli vulnerabilities. This dissertation is based on field research comparing two Hindu villages in northwest Nepal during 2009 and 2010. One village had more extensive ties to development than the other, and these villagers and other change agents co-created transitional contexts of vulnerability in the post-conflict setting of rural Nepal. An armed conflict dominated the political landscape in Nepal for …
The Archaeological Investigation Of Cedar Bark Basket Trees In Western Montana: Background, Methods, And Trial Study Of Culturally Modified Trees, Dean Sonneah Nicolai
The Archaeological Investigation Of Cedar Bark Basket Trees In Western Montana: Background, Methods, And Trial Study Of Culturally Modified Trees, Dean Sonneah Nicolai
Graduate Student Theses, Dissertations, & Professional Papers
This thesis explores the potential for archaeological investigations of culturally modified trees (CMTs) in the northern Rocky Mountain region of Western Montana. Culturally modified trees are considered to be living artifacts, representations of traditional culture, and a lasting physical manifestation of long term use by inhabitants. The goal of this thesis is to offer an archaeological perspective for investigation of cultural modifications of the cedar basket tree (Thuja plicata), and to contribute to the development of a method for inquiry and analysis. Two primary research questions were posed: How does the study of behavioral archaeology and the methodological approach presented …
Responses To Climate Change In National Park Service Wilderness: What Is Happening In The Field?, Katherine E. Nelson
Responses To Climate Change In National Park Service Wilderness: What Is Happening In The Field?, Katherine E. Nelson
Graduate Student Theses, Dissertations, & Professional Papers
As scholars debate whether climate change warrants more or less active management in wilderness, this baseline study identifies what is happening on the ground. This study focuses attention on National Park Service units that administer designated wilderness. Representatives who had been identified by the superintendents from each of these units responded to an online survey (with a 94% response rate). Respondents reported on their concerns, monitoring, and management projects driven by climate change happening in their wilderness. Respondents also discussed whether and how these activities affected wilderness character. This is the first study to characterize the response to climate change …
Salmon & Steelhead Hatcheries: Conservation Or Condemnation?, Samuel Hunter Lungren
Salmon & Steelhead Hatcheries: Conservation Or Condemnation?, Samuel Hunter Lungren
Graduate Student Theses, Dissertations, & Professional Papers
Wild salmon and steelhead are as fundamental to the Pacific Northwest as evergreen trees and rain. For thousands of years ecosystems and economies have relied on the bountiful marine nutrients annually running inland from the Pacific Ocean in the form of large, silver fish. Even today, the chance to tangle with one of these wild gems is one of the greatest gifts the Northwest has to offer. Early settlers of the West Coast witnessed seemingly infinite salmon abundance. But as time passed and humans increasingly exploited both salmon and their ecosystems, they found out just how finite salmon really were. …
Women’S Water, Women’S Work: Evaluating Decentralized Management Of Deep Borehole Wells For Improved Rural Water Access In Tawa Fall Village, Senegal, Tenly Elizabeth Snow
Women’S Water, Women’S Work: Evaluating Decentralized Management Of Deep Borehole Wells For Improved Rural Water Access In Tawa Fall Village, Senegal, Tenly Elizabeth Snow
Graduate Student Theses, Dissertations, & Professional Papers
Throughout the developing world, countries face a number of issues regarding the health and welfare of their populations. One issue that stands out with critical and growing importance is the availability-and accessibility-of water. Across the Sahel, access to potable water for domestic use, as well as contaminant-free water for agricultural and animal husbandry purposes is of growing concern. This study evaluates Government of Senegal efforts at improving rural water access through public-private operation contracts to manage deep groundwater resources. In West Africa, Senegal currently counts itself among the few Sahelian countries having sufficient freshwater supplies to support its population’s growing …
Expanding, Refining, And Replicating Research On High School Gay-Straight Student Alliances And Sexual Minority Youth, Nicholas Christopher Heck
Expanding, Refining, And Replicating Research On High School Gay-Straight Student Alliances And Sexual Minority Youth, Nicholas Christopher Heck
Graduate Student Theses, Dissertations, & Professional Papers
Sexual minority youth are at-risk for engaging in negative health behaviors and for experiencing at-school victimization. Specific benefits of attending a high school with a gay-straight student alliance (GSA), including lower risk for suicide, fewer alcohol problems and lower levels of psychological distress, have been reported. Limitations in the previous research studies, especially the use of retrospective designs, small sample sizes, and samples limited to a single geographic region, call into question the generalizability of these benefits. In an effort to overcome the aforementioned limitations, this analysis of data from 316 sexual minority high school students identified individual/family-, community-, and …
Mechanisms And Cytotoxic Effects Of Nqo1-Directed Lavendamycin Derivatives And Mitochondria-Targeted Anthracenyl Isoxazole Amides As Novel Antitumor Agents, Alison King Kearns
Mechanisms And Cytotoxic Effects Of Nqo1-Directed Lavendamycin Derivatives And Mitochondria-Targeted Anthracenyl Isoxazole Amides As Novel Antitumor Agents, Alison King Kearns
Graduate Student Theses, Dissertations, & Professional Papers
Cancer is a common, complex, and oftentimes fatal disease. Despite extensive research in the field of cancer drug discovery, there are still improvements to be made in the design of effective anticancer agents. This project involved three separate but related studies that fall under the category of anticancer drug discovery as a whole. The overall goal of this project was to design and investigate the mechanisms of action of new antitumor agents to be used against solid tumors. First, we developed a series of anthracenyl isoxazole amides (AIMs) designed to bind to G-quadruplex DNA and inhibit telomerase. Results from this …