Digital Commons Network^™

Voclosporin‐Induced Gingival Enlargement: A Case Report, Dimitris N. Tatakis

Faculty Scholarship

The gingiva (gums) is often a site in the mouth where changes or reactions can occur in response to certain systemic medications. Some drugs, particularly those used to treat autoimmune conditions or following organ transplants, can cause the gums to grow excessively, a condition known as drug-induced gingival enlargement (also known as gingival overgrowth). In this report, we document the case of a 27-year-old woman with lupus nephritis who developed gingival enlargement after starting a medication called voclosporin. This drug is a newer treatment option for lupus nephritis, but until now had not been linked to gingival enlargement. The patient …

Grid Fragility, Blackouts, And Control Co-Design Solutions, Mario Garcia-Sanz

Faculty Scholarship

The grid is undergoing a large-scale transformation, including a significant reduction of synchronous generators, a high penetration of inverter-based resources and renewables, substantial demand growth, new extra-large loads, aging infrastructure and a concerning vulnerability to contingencies. Some of the recent massive blackouts in Spain/Portugal, Chile and Texas are exposing the fragility of the grid as we know it today. This paper introduces new solutions to stabilize the grid under undesired dynamic interactions and extreme contingencies, with the goal of avoiding cascading failures and blackouts. Using control co-design methodologies, the paper proposes three interdependent categories to improve the reliability and controllability …

Intraspecific Competition Can Promote Population-Level Specialization, Abdel H. Halloway

Faculty Scholarship

The hypothesis of competitive diversification asserts that increased intraspecific competition will cause a population to generalize in resource use. The reasoning is that as preferred resources are depleted, individuals which use alternative resources become more fit, leading to an overall broadening of resource use. However, recent studies have shown instances of the opposite effect: increased intraspecific competition leading to increased population resource specialization. We explored how intraspecific competition could affect population resource specialization by creating an evolutionary game theoretic consumer-resource model in which individuals have both resource use preference and resource use breadth which are flexible and adaptable. Using this …

Effects Of Heating Orientation On Flow Boiling In Copper Manifold Microchannel Heat Sinks, Huigang Wang, Yue Qiu, Jennifer Carter, James Mcguffin-Cawley, Chirag R. Kharangate

Faculty Scholarship

Recently, two-phase cooling configurations are being proposed to meet the power dissipation requirements of high heat flux electronic devices. Flow boiling in Manifold Microchannel (MMC) offers high heat transfer coefficients with low pressure drops, making it a popular choice. While many studies have explored flow boiling in microchannels, the influence of heating orientation in MMCs with complex 3D flow paths has not been investigated thoroughly. In this study, experiments are conducted to investigate the effects of heating orientations and mass flow rates on heat transfer performance, pressure drop, and the hysteresis phenomenon during flow boiling in a copper manifold microchannel …

Risk-Sensitive Markov-Perfect Equilibrium, Matthew J. Sobel

Faculty Scholarship

We investigate the existence and structure of Markov-perfect equilibria of discrete-time dynamic games in which players are risk averse and have time preferences consistent with discounting. We establish the existence of a Markov-perfect equilibrium when each player strives to maximize the expected exponential utility of the present value of the time stream of rewards. Also, we give sufficient conditions for a Markov-perfect equilibrium to be myopic, namely to be a sequence of Nash equilibria of static games. The myopia results are applied to a dynamic oligopoly model in which firms choose prices and production quantities, encounter stochastic demand and hold …

Association Of Medicaid Expansion With Colon Cancer Care: Treatment Patterns And Survival In Non-Metastatic Cases From State Registry-Claims Data, Kirsten Y. Eom, Weichuan Dong, Richard S. Hoehn, Jeffrey M. Albert, Uriel Kim, Gregory Cooper, Johnie Rose, Siran M. Koroukian

Faculty Scholarship

Purpose: Despite growing research on Medicaid expansion’s impact on cancer outcomes, there remains a critical need for a more nuanced understanding of how expansion affects cancer care and survival. This study assesses whether Medicaid expansion was associated with improved receipt of standard treatment, timely treatment initiation, and overall survival among colon cancer patients, while examining the specific factors influencing these outcomes. Methods: Using Ohio’s state cancer registry linked with Medicaid records, we analyzed 688 Medicaid-enrolled patients with non-metastatic colon cancer diagnosed between May 2011 and December 2017. We employed multivariable Poisson and Cox proportional hazard regression analyses to evaluate the …

Computational Model Predicts Function Of Rho-Gtpase Binding For Plexin Receptor Gap Activity On Rap1b Via Dynamic Allosteric Changes, Nisha Bhattarai

Faculty Scholarship

Plexin-semaphorin signaling regulates key processes such as cell migration, neuronal development, angiogenesis, and immune responses. Plexins stand out because they can directly bind with both Rho- and Ras-family small GTPases through their intracellular domains when these GTPases are in their active, GTP-bound states. This binding occurs via intracellular regions, which include a Rho-GTPase binding domain and a GTPase-activating protein (GAP) segment. Studies have shown that Rho and Ras GTPases play vital roles in plexin signaling and activation. However, the structural dynamics of plexins and GTPases and how these conformational changes affect interactions when plexin is bound with both Ras and …

Management Of Severe Gingival Recession Using A Double Papilla Connective Tissue Graft: A 2-Year Follow-Up Case Study, Dimitris N. Tatakis

Faculty Scholarship

Gum recession is a common condition where the gum tissue pulls away from the teeth, exposing the roots and making them more prone to damage. This report describes the treatment of a 30-year-old woman who had severe gum recession on her lower left canine tooth, caused by her long-term habit of scratching the gums with her fingernail. To restore the lost tissue and protect the tooth, a double papilla flap (a surgical technique that moves nearby tissue) along with a connective tissue graft (transplanted tissue from the roof of the mouth) was used. Over 2 years, the recession was reduced …

The Structure Of The Drp1 Lattice On Membrane, Kristy Rochon, Anelise N. Hutson, Jason A. Mears

Faculty Scholarship

Mitochondrial health relies on the membrane fission mediated by dynamin-related protein 1 (Drp1). Previous structural studies of Drp1 on remodeled membranes were hampered by heterogeneity, leaving a critical gap in the understanding of the mitochondrial fission mechanisms. Here we present a cryo-electron microscopy structure of full-length human Drp1 decorated on membrane tubules. Using the reconstruction of average subtracted tubular regions (RASTR) technique, we report that Drp1 forms a locally ordered lattice along the tubule without global helical symmetry. The filaments in the lattice are similar to dynamin rungs with conserved stalk interactions. Adjacent filaments are connected by GTPase domain interactions …

On Simple Competition Policy, Keith N. Hylton

Faculty Scholarship

These remarks address the topic of “simple competition policy for a complex world”.[1] There is much to be said in favor of simplicity in legal rules. Complex legal rules are often difficult for the individuals who must comply with the rules to understand what they mean. Complex rules are often confusing, and take a long time to understand, when in the real business world decisions must be made quickly – at the pace at which business occurs. Businessmen do not have the luxury that academics possess to read, discuss, and think about rules for long periods of time. Markets …

Role Of Autonomic Dysfunction In Initiating Postoperative Atrial Fibrillation In A Canine Sterile Pericarditis Model, Seungyup Lee, Don W. Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita

Faculty Scholarship

Background: Autonomic dysfunction plays a significant role in initiating postoperative atrial fibrillation (POAF) by causing atrial ectopic triggers, potentially through mechanisms such as increased sympathetic activity and altered vagal tone. These atrial ectopic triggers can easily induce POAF, especially in the presence of vulnerable substrates such as pericardial inflammation or structural remodeling. Objective: To test the hypothesis that autonomic dysfunction causes atrial ectopic triggers or POAF in the canine sterile pericarditis model. Methods: Ten sterile pericarditis dogs were studied on postoperative Days 2−3. Autonomic dysfunction was induced by stellate ganglion nerve stimulation (SNS, 5–15 mA; 4–10 Hz; pulse width 0.5–5 …

Opinion: The Constitution - Not Trump - Demands Our Allegiance, Christian G. Fritz

Faculty Scholarship

Supporting the Constitution not only requires submission to constitutional authority but implies resistance to powers that are exercised unconstitutionally. Such resistance might take the form of brave individuals living up to their oath of office or courts defending the rule of law and the Constitution. But while the Supreme Court plays a key role in interpreting the Constitution and holding a president in check, it has long been recognized that others besides the court have always been necessary to help monitor America’s constitutional order. The practice of resisting unconstitutional acts of the federal government by sounding the alarm was described …

Electrochemically-Assisted Low Power Density Laser Writing On Stainless Steel Via Enrichment Of Chromium Oxides, Zechariah J. Pfaffenberger, Lianlian Liu, Tae Kyong John Kim, Vignesh Venkataramani, Lydia Kisley

Faculty Scholarship

Laser color marking produces nearly permanent, environmentally friendly, vibrant colors on surfaces. However, previous work has used high-power-density pulsed lasers to induce the physicochemical reactions for marking. Here, laser color marking on stainless steel 304 (SS304) is performed with a less expensive continuous wave (CW) laser and a power density five orders of magnitude below that previously reported by combining an electrochemical cell with a fluorescence microscope. Using a combination of optical microscopy, x-ray photoelectron spectroscopy, and bulk electrochemistry, it is demonstrated that the laser-induced luminescence and colors are due to enrichment (32 ± 9% increase) of Cr₂O₃ in the …

Multi-Omic Spatially Resolved Analysis Of The Neuroinflammatory Response To Intracortical Microelectrode Arrays, E. Ricky Chan, Jeffrey R. Capadona

Faculty Scholarship

Intracortical microelectrode arrays (MEAs) are devices implanted into the brain's cortex with the ability to record or stimulate neuronal activity. Unfortunately, MEAs tend to fail over chronic time points, limiting their clinical utility. Chronic failure has largely been attributed to the brain's neuroinflammatory response. Until recently, most of what was understood about the neuroinflammatory response to MEAs was learned through immunohistochemical analysis of small numbers of proteins. More recently, gene expression studies have sequenced thousands of mRNA molecules that contribute to neuroinflammation, but few studies have performed large-scale proteomic analyses. To expand the knowledge of molecular mechanisms involved, we have …

Methodological Considerations For Optimal Variable Selection In Machine Learning For Health Services Research, Weichuan Dong, Trisha Lal, Fangzhou Liu, Peter Pronovost, Samudragupta Bora, Richard S. Hoehn

Faculty Scholarship

Effective variable selection is central to the success of health services research, where large, complex datasets often include numerous variables with varying degrees of relevance. This paper presents a structured approach to variable selection, highlighting the importance of combining domain expertise with advanced analytical techniques to ensure the inclusion of only the most pertinent variables. We explore several methods, including manual selection, correlation matrices, random forests, and stepwise regression, each with its strengths and limitations in managing multicollinearity, dimensionality, and interpretability. By carefully preprocessing variables—removing redundant, irrelevant, or missing data—and applying feature selection tools like decision tree-based algorithms, researchers can …

The Use Of Partial Textual Stimuli Within An Interactive Task For Increasing Reports Of Past Behavior With A Child With Autism, Masyn S. Mcwilliams, Robbie Hanson

Faculty Scholarship

Individuals with autism spectrum disorder (ASD) may face challenges with reporting past behavior. Although some behavior-analytic studies have shown success with increasing these reports, the use of materials within activities that do not repeat has not been assessed (e.g., Shillingsburg et al., 2017). Thus, the purpose of the current study was to expand upon previous research (e.g., Shillingsburg et al. 2017; 2019) by utilizing novel materials within activities completed and examining the use of partial textual stimuli within an interactive task to increase reports of past behavior for one child with autism. The results showed an increase in reports of …

Art, Play, And Neuroplasticity: Advancing Dementia Care Through Art-Enriched Environments, Piper Hutson, James Hutson

Faculty Scholarship

Dementia represents a global public health crisis, characterized not only by progressive memory loss but by a pervasive decline in cognitive flexibility, social functioning, and overall quality of life. Traditional therapeutic modalities, often limited to pharmacological management and cognitive training, have yielded only modest gains in symptom mitigation and patient well-being. Recent advances in neuroscience have illuminated the brain‘s capacity for neuroplasticity—its inherent ability to adapt, reorganize, and form new neural connections even in advanced age and the presence of neurodegenerative conditions. This emerging understanding invites a critical re-evaluation of dementia care strategies, highlighting the potential of non-pharmacological interventions to …

Scaffolded Integration: Aligning Ai Literacy With Authentic Assessment Through A Revised Taxonomy In Education, James Hutson

Faculty Scholarship

The accelerating prevalence of generative artificial intelligence in educational and professional spheres necessitates a reevaluation of when and how such technologies are introduced within pedagogical practice. The principal challenge for educators is not merely the imperative to prepare students for an AI-driven world, but rather to ensure that assessment practices remain authentic—providing an accurate measure of what students can independently achieve before leveraging the augmentation potential of intelligent systems. This article contends that the incremental introduction of AI, mapped onto a scaffolded framework aligned with a revised Bloom’s Taxonomy, constitutes a methodologically sound approach for maintaining academic integrity, fostering transferable …

Looking For The Public In Public Law, Nikhil Menezes, David E. Pozen

Faculty Scholarship

The “public” is everywhere and nowhere in contemporary public law. Everywhere, in that the term is constantly invoked to justify and explain existing arrangements. Nowhere, in that serious attempts to identify a relevant public and elicit its input are few and far between. Scholars and officials depict the U.S. public as playing myriad roles in governance — checking, guiding, approving, repudiating—without offering an account of how public preferences are formed or how they exercise influence on questions of interest.

This Article seeks to identify and call attention to the foundational dilemmas underlying this disconnect, to clarify their normative contours and …

How Domestic Institutions Shape The Global Tech War, Anu Bradford, Eileen Li, Matthew C. Waxman

Faculty Scholarship

The United States (U.S.), China, and the European Union (EU) are engaged in a national security-driven economic competition over advanced technology. Many scholars and commentators focus on the external dimension of this geopolitical contest; that is, they describe the strategic choices by each actor in terms of geopolitical realities, threat perceptions, and relative power. However, this Article brings to the fore the internal dimension of the global tech war. We argue that each player’s strategy in the tech war is a function of its internal features, including basic constitutional powers, domestic legal institutions, and the relationships between the government and …

After Notice And Choice: Reinvigorating “Unfairness” To Rein In Data Abuses, Lina M. Khan, Samuel A.A. Levine, Stephanie T. Nguyen

Faculty Scholarship

The Federal Trade Commission (FTC) has long served as America’s default privacy enforcer. Yet for much of its history, the agency relied on self-regulation through a “notice and choice” framework that left the public vulnerable in an era of rampant data collection and digital surveillance. Businesses overwhelmed users with dense privacy notices while amassing and exploiting vast troves of personal data. The agency’s historical approach, rooted in outdated assumptions about self-correcting markets and an ideologically cramped view of the FTC’s authorities and mandate, helped usher in a digital economy where data abuses became routine.

During the Biden Administration, the FTC …

Addressing Missingness In Serialized Bureaucratic Data: The Case Of Chinese Courts, Xiaohan Wu, Margaret Roberts, Rachel E. Stern, Benjamin L. Liebman, Amarnath Gupta, Luke Sanford

Faculty Scholarship

Courts around the world are putting their data online, making information about caseloads, parties, and decisions available to the public. Yet, this data is far from complete, and often only reflects a portion of courts’ dockets. We offer and validate a set of tools for leveraging serialized bureaucratic data from courts to estimate the proportion of cases available to the public and the time courts take to make decisions. Using data from more than 3,000 courts in China, our methods allow us to assess patterns of missingness in court data across provinces and cities by type of case and to …

Litigating National Security In The Wto Era, Petros C. Mavroidis

Faculty Scholarship

From one dispute between 1948 and 1994, there have now been 14 requests for a panel establishment (based on the General Agreement on Tariffs and Trade (GATT), Article XXI – the exception for national security) during the World Trade Organization (WTO) era (1995–now). The majority of them ended up in the issuance of a panel report, all of which were issued after 5 April 2019. As the WTO Appellate Body has been dysfunctional as of November 2019, no appellate report has been issued. Appeals have been lodged, but as there is no Appellate Body to entertain them, they were lodged …

Beyond Issuers: The Future Of Private Securities Litigation, Joshua Mitts

Faculty Scholarship

Private securities litigation has traditionally been viewed as a subfield of corporate governance, reducing agency costs by disciplining wayward management. In this brief Symposium essay, I argue that the future of private securities litigation lies beyond issuers. I discuss how a fraud claim under Rule 10b-5 can be understood as a kind of economic tort, and set out, in broad strokes, an economic analysis of claims against non-issuer defendants. I then consider emerging trends in the case law against non-issuers in social media and market manipulation cases. I conclude by identifying some challenges and opportunities for securities litigation in a …

(De)Funding Family Separations, Joshua Gupta-Kagan

Faculty Scholarship

Federal foster care funding exists in tension with foundational family law principles. The law protects family integrity: the state may only separate parents and children in extreme cases, and, when it does, the state must work to reunify families. Yet the federal funding system directs billions of federal dollars to support CPS agencies and pay subsidies to foster parents, adoptive parents, and guardians. It does so via an open-ended entitlement, so that the more families a state separates, the more federal funds it receives. This system makes it relatively cheaper for CPS agencies to take custody of children, incentivizes states …

Competence-Competence, Delegation, And The Aaa/Icdr Rules, Christopher R. Drahozal, George A. Bermann, Jack J. Coe Jr., Catherine A. Rogers

Faculty Scholarship

In 2021 and 2022, the American Arbitration Association (AAA) and the International Centre for Dispute Resolution (ICDR) amended their arbitration rules to address a “potential controversy” said to be caused by the Restatement of the U.S. Law of International Commercial and Investor-State Arbitration. The “potential controversy” is over whether the rules providing that arbitrators have “the power to rule on [their] own jurisdiction” should be interpreted as delegation clauses — that is, as “clearly and unmistakably” delegating exclusive authority to resolve jurisdictional challenges to the arbitrators instead of the court. Most courts have so interpreted the rules.

By contrast, the …

Digital Resurrection Of Thonis-Heracleion: Technological Advances In Underwater Archaeology And A Speculative Ai-Driven Reconstruction Methodology, James Hutson, Passent Chahine

Faculty Scholarship

This article synthesizes past archaeological research on the submerged Egyptian city of Thonis-Heracleion, critically reviewing excavations and technological interventions deployed since its rediscovery by Franck Goddio and the IEASM team. Situated approximately 10 meters beneath Aboukir Bay near Alexandria, the city represents a significant nexus of Greek and Egyptian cultural heritage, vividly documented in classical sources such as Herodotus and Strabo. Prior excavations have recovered temple complexes, colossal statues, ritual artifacts, and an extensive array of ancient shipwrecks, mapping only a fraction of the extensive site. These investigations utilized pioneering geophysical methods, including multibeam sonar, side-scan sonar, and photogrammetry, establishing …

Virtual Reality In Undergraduate And Postgraduate Nursing Education: A Scoping Review Protocol Integrating Data Mining For Topic Discovery, Celeste Alfes

Faculty Scholarship

Virtual Reality (VR) encompasses a range of computer-based technologies that simulate complex scenarios, offering immersive, experiential learning in a controlled virtual environment. In nurs- ing education, VR has the potential to enhance both technical and non-technical competencies. However, the existing literature on VR in nursing education is fragmented, making it challenging to fully grasp its scope, applications, and emerging trends. This scoping review protocol outlines a systematic approach to mapping the existing literature on the use of VR in undergraduate and postgraduate nursing education. Following Joanna Briggs Institute guidelines and the PRISMA- ScR 2020 framework, the review will include studies …

A Toda Bracket Convergence Theorem For Multiplicative Spectral Sequences, Eva Belmont

Faculty Scholarship

Moss’ theorem, which relates Massey products in the -page of the classical Adams spectral sequence to Toda brackets of homotopy groups, is one of the main tools for calculating Adams differentials. Working in an arbitrary symmetric monoidal stable simplicial model category, we prove a general version of Moss’ theorem which applies to spectral sequences that arise from filtrations compatible with the monoidal structure. This involves the study of Massey products and Toda brackets in a non-strictly associative context. The theorem has broad applications, e.g., to the computation of the motivic slice spectral sequence and other colocalization towers.

Competition In The Global Law Market: Offshore Development Of The Statutory "Rule In Hastings-Bass", Andrew P. Morriss

Faculty Scholarship

This Article examines the competitive dynamics in the global law market through the lens of the statutory evolution of the Rule in Hastings-Bass across various International Financial Centers (IFCs). Following the UK Supreme Court's 2013 decision in Pitt v Holt and Futter v Futter, which significantly restricted the judiciary's ability to void trustee decisions under the Rule, seven IFCs (Jersey, Bermuda, The Bahamas, the Dubai International Financial Center, the Cayman Islands, and the British Virgin Islands) enacted statutes to preserve and clarify the Rule within their jurisdictions. These legislative actions highlight the strategic adaptations by IFCs to enhance their legal …