Digital Commons Network^™

Dietary Effects On The Retina Of Hamsters, Nicole El-Darzi, Natalia Mast, Yong Li, Irina A. Pikuleva

Faculty Scholarship

The retina is a sensory tissue in the back of the eye, which captures visual information and relays it to the brain. The retinal pigment epithelium separates the neural retina from the choroidal (systemic) circulation and is thereby exposed to circulating lipoprotein particles. Herein, we used hamsters and conducted various retinal evaluations of animals fed either a normal diet or a Western-type diet (WTD). Prior to evaluations, hamsters were injected with indocyanine green (ICG), a fluorescent dye that binds to various proteins and lipids in the systemic circulation. The WTD increased plasma levels of total and HDL cholesterol 1.8- and …

Improving The Transparency Of Legal Measurement In Health Policy Evaluation—A Guide For Researchers, Reviewers, And Editors, Benjamin A. Barsky, Alina Schnake-Mahl, Cason D. Schmit, Scott Burris

Faculty Scholarship

Advances in quantitative research methods have led to acceptance that well-designed observational studies can enable causal inferences about the effects of policy interventions on health. Indeed, JAMA recently announced exploring a range of study designs for which causal interpretations may be made in JAMA Network journals. This development is welcome for research on the potential health effects of laws—including statutes, regulations, executive orders, formal agency guidance, and other documents that purport to require compliance with rules or standards—given that they are rarely amenable to evaluation using experimental methods. As researchers, reviewers, and editors refine criteria for assessing the appropriateness of …

Neuropeptide-Dependent Spike Time Precision And Plasticity In Circadian Output Neurons, Bryan Chong, Vipin Kumar, Dieu Linh Nguyen, Makenzie A. Hopkins, Faith S. Ferry, Lucia K. Spera, Elizabeth M. Paul, Anelise N. Hutson, Masashi Tabuchi

Faculty Scholarship

Circadian rhythms influence various physiological and behavioral processes such as sleep–wake cycles, hormone secretion, and metabolism. In Drosophila, an important set of circadian output neurons is called pars intercerebralis (PI) neurons, which receive input from specific clock neurons called DN1. These DN1 neurons can further be subdivided into functionally and anatomically distinctive anterior (DN1a) and posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) and 44 (Dh44) are the insect neuropeptides known to activate PI neurons to control activity rhythms. However, the neurophysiological basis of how Dh31 and Dh44 affect circadian clock neural coding mechanisms underlying sleep in Drosophila is …

Flapping Dynamics And Wing Flexibility Enhance Odor Detection In Blue Bottle Flies, Naeem Haider, Zhipeng Lou, Chengyu Li

Faculty Scholarship

One of the most ancient and evolutionarily conserved behaviors in the animal kingdom involves utilizing wind-borne odor plumes to track essential elements such as food, mates, and predators. Insects, particularly flies, demonstrate a remarkable proficiency in this behavior, efficiently processing complex odor information encompassing concentrations, direction, and speed through their olfactory system, thereby facilitating effective odor-guided navigation. Recent years have witnessed substantial research explaining the impact of wing flexibility and kinematics on the aerodynamics and flow field physics governing the flight of insects. However, the relationship between the flow field and olfactory functions remains largely unexplored, presenting an attractive frontier …

Book Review: How To Set Up And Run A Law Clinic, Peggy Maisel, Paul R. Tremblay

Faculty Scholarship

This book answers many questions for those tasked with deciding whether and how to fund a law school clinic. It also provides metrics by which to evaluate the operations of a clinic. And finally, this book addresses not just how best to run a clinic, but in many ways how best to deliver legal services to a community in great need of legal help, whether through a law school program or in the neighborhood. It answers questions every legal aid office in the world with limited resources must answer: how to choose clients, how to decide which services the clients …

Human Mesenchymal Stem Cell Therapy: Potential Advances For Reducing Cystic Fibrosis Infection And Organ Inflammation, Tracey L. Bonfield, Hillard M. Lazarus

Faculty Scholarship

Innovation in cystic fibrosis (CF) supportive care, including implementing new antimicrobial agents, improved physiotherapy, and highly effective modulators therapy, has advanced patient survival into the 4th and 5th decades of life. However, even with these remarkable improvements in therapy, CF patients continue to suffer from pulmonary infection and other visceral organ complications associated with long-term deficient cystic fibrosis transmembrane conductance regulator (CFTR) expression. Human mesenchymal stem cells (MSCs) have been utilized in tissue engineering based upon their capacity to provide structural components of mesenchymal tissues. An alternative role of MSCs, however is their versatile utilization as cell-based infusion powerhouses due …

Reclaiming Abortion As A Moral—And Religious—Decision, Linda C. Mcclain

Faculty Scholarship

Elizabeth Sepper, Free Exercise of Abortion, 49 BYU L. Rev. 177 (2023).

In 1973, before the Supreme Court decided Roe v. Wade, two members of a group of clergy committed to helping women receive abortion care stated: “every woman must possess the freedom, guaranteed by the U.S. Constitution, to follow her religious conscience in the determination of whether she will or will not bear a child.”1 Religious supporters of abortion access also cited the Establishment Clause: states were adopting, in a religiously diverse nation, a religious view about when life begins and how to value fetal and maternal life. …

Heterogeneity Of Layer 1 Interneurons In The Mouse Medial Prefrontal Cortex, Chen Shen, Wanpeng Cui, Wen Cheng Xiong, Lin Mei

Faculty Scholarship

Cortical Layer 1 (L1) acts as a critical relay for processing long-range inputs. GABAergic inhibitory interneurons (INs) in this layer (Layer 1 interneurons [L1INs]) function as inhibitory gates, regulating these inputs and modulating the activity of deeper cortical layers. However, their characteristics and circuits in the medial prefrontal cortex (mPFC) remain poorly understood. Using biocytin labeling, we identified three distinct morphological types of mPFC L1INs: neurogliaform cells (NGCs), elongated NGCs (eNGCs), and single-bouquet cell-like (SBC-like) cells. Whole-cell recordings revealed distinct firing patterns across these subtypes: NGCs and eNGCs predominantly exhibited late-spiking (LS) patterns, and SBC-like cells displayed a higher prevalence …

Plasmonic Enhancement Of Photothermal Conversion Efficiency In Gold-Nanoparticle Hydrogels, Mai S. Rashwan, Abed M. Al-Sheikh, Harihara Baskaran, Clemens Burda

Faculty Scholarship

This study investigates the photothermal properties of citrate-capped gold nanoparticles (Au NPs) dispersed in agarose gel, examining various sizes and concentrations, particularly within a low-concentration range (0.2–2.5 nM). Heat transfer measurements are conducted on Au NP hydrogels using laser-light induced heating, revealing a size- and concentration-dependent temperature increase compared to the plain agarose gel matrix. Experimental data, combined with finite-element analysis, demonstrate that photothermal energy conversion efficiencies are dependent on NP size and concentration, while the thermal conductivity (TC) of all Au NP hydrogels remains constant and independent of these parameters within the tested concentration range. UV-visible spectroscopy indicates that …

The Baryonic Tully-Fisher Relation. Ii. Stellar Mass Models, Francis Duey, Stacy Mcgaugh

Faculty Scholarship

We present new color-ϒ* (mass-to-light ratio) models to convert Wide-field Infrared Survey Explorer W1 fluxes into stellar masses. We outline a range of possible star formation histories and chemical evolution scenarios to explore the confidence limits of stellar population models on the value of ϒ*. We conclude that the greatest uncertainties (around 0.1 dex in ϒ*) occur for the bluest galaxies with the strongest variation in recent star formation. For high-mass galaxies, the greatest uncertainty arises from the proper treatment of bulge-disk separation in which to apply different ϒ* relations appropriate for those differing underlying stellar populations. We compare our …

Pirfenidone Delivery By Blow-Molded Pcl Nanofiber Mat To Reduce Collagen Synthesis By Fibroblasts, Maximilian Zernic, Maryo Kohen, Faruk H. Orge, Amel Ahmed, Ozan Akkus

Faculty Scholarship

Elevated intraocular pressure (IOP) during glaucoma is sometimes mitigated by insertion of glaucoma drainage devices (GDD). Excessive fibrosis around GDD plates may confine drainage and requiring revision surgeries in some patients. Pirfenidone (PFD) is an FDA approved drug to treat lung fibrosis, and it may be effective in limiting capsule formation around the GDD. To enable this, we aimed to develop a polymeric GDD encasement sheath that can sustainably release PFD to reduce fibrous capsule formation. The PFD-doped sheath was manufactured by blow molding of (poly)caprolactone (PCL). We investigated the effects of PCL concentration, spray distance, and molecular weight on …

The Virtual Wunderkammer: Integrating Neuroinclusive Design And Ai-Augmented Technologies For Immersive Museum Experiences, Piper Hutson, James Hutson

Faculty Scholarship

The Virtual Wunderkammer represents an innovative paradigm in museum exhibition design, integrating neuroinclusive principles with artificial intelligence (AI)-augmented technologies to foster immersive and cognitively accessible visitor experiences. Historically, the Wunderkammer, or "cabinet of curiosities," served as a precursor to modern museums, offering eclectic collections that stimulated intellectual curiosity and sensory engagement. The contemporary reimagining of this concept utilizes emerging technologies such as augmented reality (AR), virtual reality (VR), haptic feedback, and olfactory-enhanced digital environments to create personalized, adaptive museum experiences. This study explores the critical intersection of neuroaesthetics, cognitive science, and AI-driven interactivity in digital exhibitions, emphasizing their potential to …

Celebrating 70 Years Of Health Law At Bu, Christopher Robertson, Elizabeth Mccuskey, Aziza Ahmed, Dionne Lomax, Kathryn Zeiler, Dianne Mccarthy, Laura Stephens, Michael Ulrich, Lawrence Vernaglia, Danielle Pelfrey Duryea, Nicole Huberfeld, Kevin Outterson

Faculty Scholarship

This essay celebrates the BU Health Law Program upon its 70th anniversary, offering reflections on the founders of the program, Fran Miller, George Annas, and Wendy Mariner (“FGW,” endearingly), and their contributions to the field.

Current faculty offer reflections, including: Several speak to scholarly research, including Elizabeth McCuskey on health care finance, Aziza Ahmed on human rights, Dionne Lomax on antitrust, Christopher Robertson on trust, and Kathy Zeiler on the marketplace. Other contributors speak to the student experience, with Dianne McCarthy on mentorship, Laura Stephens on demanding excellence, Michael Ulrich on teaching, and Larry Vernaglia on merging law and public …

Climate Change Litigation In New York, Michael B. Gerrard

Faculty Scholarship

Numerous lawsuits have been brought in the federal and state courts in New York concerning climate change. Some were under two important state statutes on the subject – the Climate Leadership and Community Protection Act of 2019 (CLCPA)and New York Climate Superfund Act of 2024. Others are brought under various common law, consumer protection, securities, and other theories. This column describes the most important of these cases.

Public Funds, Public Functions, Private Actors: The Cognitive Dissonance Of Us Health Law, William M. Sage

Faculty Scholarship

This chapter begins with the evolution of American medicine from a “sovereign” self-regulating profession focused on direct patient service to a large industry that serves the social sector but that, because of its professional heritage, receives extensive public subsidies without equivalent public accountability. Next, the chapter identifies regulatory dynamics in American health care governance that structurally discourage movement from the prevailing, if dissonant, private law framework to one explicitly grounded in public law. The chapter concludes by highlighting the challenges and opportunities inherent in a private law approach to what is intuitively a public law domain.

Optimal Real-Time Review Standards: Implications For Law Enforcement And Competitive Games, Murat C. Mungan

Faculty Scholarship

Real-time review systems are frequently used in various sports to monitor the decisions of referees and correct their mistakes. Interventions through these systems cause delays in games, which are perceived as being costly. This makes it optimal for these review systems to interfere with the decisions of the referee less frequently than would minimize the costs of decision errors, which I formalize through an analysis of the VAR system in football. This analysis also reveals that optimal review standards ought to be laxer when an important event (e.g., a goal) occurs between the position in which the potential error took …

Psychosocial Burden And Suicidality In Epilepsy: A Public Health Concern, Martha Sajatovic

Faculty Scholarship

The increased risk for psychosocial burden and suicidality in people with epilepsy compared to the general population is a well-established global public health concern. Suicidality risk is also increased in patients with functional seizures. The timely identification of patients at highest risk for psychosocial burden and self-harm is vital. This can pose a significant challenge for multidisciplinary clinicians caring for people with epilepsy. Early identification of social stressors and comorbid psychiatric contributors via screening are required to assist with the development of predictive models for self-harm in epilepsy; and subsequent options for treatment and the provision of adjunct supports in …

Development Of A Self-Management Tool For Individuals With Seizure Clusters: Trial Design And Methodological Report, Molly Mcvoy, Eytan Hirsch, Luisa Londono, Kari Colón-Zimmermann, Jin Seok Cho, Evelyn K. Shih, Martha Sajatovic

Faculty Scholarship

Background: Despite advances in anti-seizure medications (ASMs) for people with epilepsy (PWE), adverse outcomes, negative health events (NHEs), and breakthrough seizures remain common. Rescue medication (RM) can better manage repetitive seizures, but barriers to RM use persist. Self-management for PWE and a history of NHEs (SMART) is an evidence-based epilepsy self-management program aimed at reducing barriers and maximizing facilitators to self-care in high-risk PWE. Methods: This 2-phase, ongoing clinical trial adapts SMART to integrate RM support for PWE with repetitive seizures. Phase 1, now completed, used input from an advisory board (AB) of PWE, caregivers, and clinicians to adapt the …

Human-Ai Collaboration In Writing: A Multidimensional Framework For Creative And Intellectual Authorship, James Hutson

Faculty Scholarship

The integration of AI technologies into the writing process has significantly altered traditional notions of authorship, creativity, and intellectual labor. Historically, writing was seen as a human-driven cognitive and creative exercise, but with the rise of generative AI tools such as ChatGPT and Claude, the line between human and AI contributions has become increasingly ambiguous. This paper addresses the limitations of the current sliding scale model, which views AI involvement as ranging from “none” to “complete”. In its place, we propose a new multidimensional framework that more accurately reflects the complexity of human-AI collaboration in writing. The model includes axes …

Postnatal Progressive Craniosynostosis: An Unusual Case Presentation Leading To Cascade Diagnosis For Multiple Generations, Jessica T. Ogawa, Maura Guyler, Krystal L. Tomei, Howard D. Wang

Faculty Scholarship

NM_000141.5: FGFR2 c.1032G>A is a pathogenic variant that causes Crouzon syndrome through activation of a new donor splice site. This clinical report highlights the intrafamilial variability that can exist with this specific variant. The proband is a 4-year-old boy who initially presented with concern for seizures. Computed tomography and magnetic resonance imaging revealed pancraniosynostosis and Chiari 1 malformation. Papilledema on fundoscopic exam and copper beaten appearance of the skull on imaging both suggested the presence of elevated intracranial pressure. Genetic testing identified c.1032G>A (p.Ala344=) in FGFR2. Familial testing and genetic evaluation confirmed the same pathogenic variant in the …

Prevalence Of Social Determinants Of Health Risk Factors Among And Their Impact On Viral Suppression, Consistent Visits, And No-Show Rates Among Persons With Hiv Who Identify As Hispanic, Mary Cowden, Ana Clavijo, Pragnya Iyengar, Ann Avery

Faculty Scholarship

The current study examines the association between language preference, social determinants of health (SDOH) risk factors, viral load, and HIV care outcomes among individuals of Hispanic ethnicity in the United States. More than half (54%) of all participants reported having two or more unmet needs. Hispanic individuals were more likely to be at risk in 2 or more domains than their non-Hispanic counterparts. Food insecurity was the most common risk factor reported and when present, 51% of patients also reported financial resource strain. Surprisingly, when language preference was analyzed, English-preferring Hispanic patients were at higher risk of financial resource strain, …

Performing Protest, Performing Memory: Speech Act Theory And January 6, Mary Lynne Gasaway Hill

Faculty Scholarship

In daily life, memory performs a staggering array of tasks. It offers reassurance, validation, legitimation, and approval. It transgresses boundaries and polices them. It confirms understandings and undermines them. It warms our hearts and chills our blood. In the realm of protest, as this article will show, memory works through intentional language use. In the context of activism, acts of memory are often performative: they aim not just to restate the status quo, but to change something about it. This chapter operationalises J.L. Austin’s Speech Act Theory (1994, SAT) as a lens through which to examine how the contentious discourse …

Examining The Relationship Between Frailty, Operative Management, And 90-Day Mortality Across Emergency General Surgery Conditions, Caleb W. Curry, Marisa R. Imbroane, Wyatt P. Bensken, Adam T. Perzynski, Christopher W. Towe, Vanessa P. Ho

Faculty Scholarship

No abstract provided.

Scalability Of A Graph Neural Network In Accurate Prediction Of Frictional Contact Networks In Suspensions, Armin Aminimajd, Joao Maia, Abhinendra Singh

Faculty Scholarship

Dense suspensions often exhibit shear thickening, characterized by a dramatic increase in viscosity under large external forcing. This behavior has recently been linked to the formation of a system-spanning frictional contact network (FCN), which contributes to increased resistance during deformation. However, identifying these frictional contacts poses experimental challenges and is computationally expensive. This study introduces a graph neural network (GNN) model designed to accurately predict FCNs by two dimensional simulations of dense shear thickening suspensions. The results demonstrate the robustness and scalability of the GNN model across various stress levels (s), packing fractions (f), system sizes, particle size ratios (D), …

Aging Is Associated With Decreased Lactobacillus And Increased Cervicovaginal Inflammation In Canadian Women, Ha T. Dang, Laura Noel-Romas, Samantha Knodel, Kenzie Birse, Hossaena Ayele, Alicia R. Berard, Adam D. Burgener, Christina Farr Zuend

Faculty Scholarship

Problem: Aging is characterized by a general dysregulation of systemic immune responses that increases susceptibility to infections and malignancies. Immune cells in the female genital tract (FGT) are regulated by sex hormones, but little is known about the impact of aging and menopause on immunology in the FGT. Method of Study: This study conducted an age-focused sub-analysis of cervicovaginal samples collected from 47 women enrolled in the Vaginal Mucosal Systems study in Winnipeg, Canada. Paired cervicovaginal lavage and cervical cytobrush were collected and analyzed by Luminex cytokine array, mass spectrometry based metaproteomics, metabolomics, and high dimensional flow cytometry. Results: The …

Towards More Sustainable Oceans: A Review Of The Pressing Challenges Posed By Marine Plastic Litter, Peter Yang

Faculty Scholarship

Marine littering is a global challenge and a significant threat to a sustainable planet, requiring comprehensive and effective mechanisms to address it in a comprehensive manner. This study reports on a bibliometric analysis that has identified the extent to which the topic has been explored in the international literature, by focusing on geographical scope, the emphasis on (micro)plastic litter and on policy measures. Additionally, as a complement to the assessment of the recent literature on marine plastic litter, this study reviews some case studies, identifying some trends on how to cope with this problem. The findings underscore the imperative for …

Elevation In White Blood Cell Count After Corticosteroid Use In Noninfected Hospitalized Patients, Erin Sullivan, Michael B. Rothberg

Faculty Scholarship

Background: It is widely accepted that corticosteroids cause leukocytosis. Clinicians must decide whether a rise in white blood cell (WBC) count is due to steroids versus other processes like developing infection. Objective: The objective of this study is to measure the increase in white blood cell count after corticosteroid administration in hospitalized patients without malignancy, infection, or immune dysfunction. Methods: This is a retrospective cohort study from 2017 to 2018 in a single large healthcare system. We analyzed the trajectory of WBC count stratified by steroid dose. The study included nonsurgical patients admitted with at least two complete blood count …

The Evolution And Future Of Microservices Architecture With Ai-Driven Enhancements, Jill Willard, James Hutson

Faculty Scholarship

Microservices architecture has revolutionized software development by enabling the decomposition of monolithic applications into smaller, more manageable services. While this shift has reduced risks and enhanced system resiliency, the increasing complexity of managing numerous microservices presents new challenges. As Artificial Intelligence (AI) continues to evolve, there is a growing need to explore how autonomous AI agents can optimize microservices architectures, particularly in terms of communication and workflow orchestration. The purpose of this study is to investigate how AI agents can autonomously interact and manage microservices, reducing human intervention and enhancing system efficiency. The key research question guiding this investigation relates …

A Review Of Optical Flow Velocimetry In Fluid Mechanics, Gauresh Raj Jassal, Bryan E. Schmidt

Faculty Scholarship

Optical flow methods have been developed over the past two decades for application to particle image velocimetry (PIV) images with the goal of acquiring higher resolution measurements of the velocity field than conventional cross-correlation (CC)-based techniques. Numerous optical flow velocimetry (OFV) algorithms have been devised to solve the ill-posed optical flow problem, with various physics-inspired strategies to tailor them to fluid flows. While OFV can be applied to continuous scalar fields, it has demonstrated the most success on images of tracer particles, i.e. traditional planar PIV images. Compared to state-of-the-art CC algorithms, OFV methods have demonstrated an order of magnitude …

Association Between Combined Oral Contraceptive Prescription And Cervical Artery Dissection: A Retrospective Cohort Study, Robert J. Trager, Catherine P. Haering

Faculty Scholarship

Background: To date, research has identified positive associations between combined oral contraceptives (COCs) and adverse vascular events, however, evidence regarding the possible association with cervical artery dissection (CeAD) remains limited. We tested the hypothesis of a positive association between COCs and CeAD within one year following COC initiation compared to matched controls initiating intrauterine devices (IUDs), as measured by risk ratio (RR). Methods: We queried de-identified United States health records data (TriNetX, Inc.) from 2014 to 2024 for females aged 15–50 years without previous cerebrovascular disease or CeAD, creating mutually exclusive cohorts initiating either COCs or IUDs. We used propensity …