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Articles 301 - 330 of 6488
Full-Text Articles in Entire DC Network
How Engineering Students Learn And Are Impacted By Empathy Training: A Multi-Year Study Of An Empathy Program Focused On Disability And Technology, Eric Schearer
Faculty Scholarship
Measurable results of efforts to teach empathy to engineering students are sparse and somewhat mixed. This study’s objectives are (O1) to understand how empathy training affects students’ professional development relative to other educational experiences, (O2) to track empathy changes due to training over multiple years, and (O3) to understand how and what students learn in empathy training environments.
Behavior Of Rio Sao Francisco Piranhas In Response To Changes In Space And Density, Ronald G. Oldfield, Josie E. Thal, Kristen E. Lukas
Behavior Of Rio Sao Francisco Piranhas In Response To Changes In Space And Density, Ronald G. Oldfield, Josie E. Thal, Kristen E. Lukas
Faculty Scholarship
Previous observations of Rio Sao Francisco piranhas (Pygocentrus piraya) at Cleveland Metroparks Zoo revealed frequent aggressive interactions, which were associated with the injury and death of some individuals. Fishes are known to increase aggressive behavior when available space is limited. We compared the behavior of the piranhas longitudinally across three different space/density conditions: (1) in a group held in a small aquarium before the death of one individual, (2) in the same group after the death of one individual, (3) and in one individual of the group after it was later moved into a larger, multispecies aquarium. In the smaller …
The Importance Of Better Natural History Studies For Duchenne Muscular Dystrophy, David J. Birnkrant
The Importance Of Better Natural History Studies For Duchenne Muscular Dystrophy, David J. Birnkrant
Faculty Scholarship
No abstract provided.
Dietary Effects On The Retina Of Hamsters, Nicole El-Darzi, Natalia Mast, Yong Li, Irina A. Pikuleva
Dietary Effects On The Retina Of Hamsters, Nicole El-Darzi, Natalia Mast, Yong Li, Irina A. Pikuleva
Faculty Scholarship
The retina is a sensory tissue in the back of the eye, which captures visual information and relays it to the brain. The retinal pigment epithelium separates the neural retina from the choroidal (systemic) circulation and is thereby exposed to circulating lipoprotein particles. Herein, we used hamsters and conducted various retinal evaluations of animals fed either a normal diet or a Western-type diet (WTD). Prior to evaluations, hamsters were injected with indocyanine green (ICG), a fluorescent dye that binds to various proteins and lipids in the systemic circulation. The WTD increased plasma levels of total and HDL cholesterol 1.8- and …
Distributed Tikhonov Regularization For Ill-Posed Inverse Problems From A Bayesian Perspective, D. Calvetti, E. Somersalo
Distributed Tikhonov Regularization For Ill-Posed Inverse Problems From A Bayesian Perspective, D. Calvetti, E. Somersalo
Faculty Scholarship
In this article, we exploit the similarities between Tikhonov regularization and Bayesian hierarchical models to propose a regularization scheme that acts like a distributed Tikhonov regularization where the amount of regularization varies from component to component, and a computationally efficient numerical scheme that is suitable for large-scale problems. In the standard formulation, Tikhonov regularization compensates for the inherent ill-conditioning of linear inverse problems by augmenting the data fidelity term measuring the mismatch between the data and the model output with a scaled penalty functional. The selection of the scaling of the penalty functional is the core problem in Tikhonov regularization. …
Neuropeptide-Dependent Spike Time Precision And Plasticity In Circadian Output Neurons, Bryan Chong, Vipin Kumar, Dieu Linh Nguyen, Makenzie A. Hopkins, Faith S. Ferry, Lucia K. Spera, Elizabeth M. Paul, Anelise N. Hutson, Masashi Tabuchi
Neuropeptide-Dependent Spike Time Precision And Plasticity In Circadian Output Neurons, Bryan Chong, Vipin Kumar, Dieu Linh Nguyen, Makenzie A. Hopkins, Faith S. Ferry, Lucia K. Spera, Elizabeth M. Paul, Anelise N. Hutson, Masashi Tabuchi
Faculty Scholarship
Circadian rhythms influence various physiological and behavioral processes such as sleep–wake cycles, hormone secretion, and metabolism. In Drosophila, an important set of circadian output neurons is called pars intercerebralis (PI) neurons, which receive input from specific clock neurons called DN1. These DN1 neurons can further be subdivided into functionally and anatomically distinctive anterior (DN1a) and posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) and 44 (Dh44) are the insect neuropeptides known to activate PI neurons to control activity rhythms. However, the neurophysiological basis of how Dh31 and Dh44 affect circadian clock neural coding mechanisms underlying sleep in Drosophila is …
Global Aging & Geriatric Experiments In Bipolar Disorder (Gage-Bd): Building A Global Consortium Benefiting People With Bipolar Disorder In Later Life, Martha Sajatovic
Global Aging & Geriatric Experiments In Bipolar Disorder (Gage-Bd): Building A Global Consortium Benefiting People With Bipolar Disorder In Later Life, Martha Sajatovic
Faculty Scholarship
Purpose of Review: Findings from the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) project, including sociodemographic and clinical information from older age bipolar disorder (OABD) and healthy participants around the globe (approximately N = 5000) were reviewed. Data was collected in multiple waves to create a large integrated dataset. Recent Findings: BD does not seem to fade with age. BD subtype and early/late onset did not show significant differences in daily functioning. Physical comorbidities were more frequent in OABD compared with controls. Women with OABD had an earlier age at onset and more psychiatric hospitalizations. Summary: GAGE-BD is …
Flapping Dynamics And Wing Flexibility Enhance Odor Detection In Blue Bottle Flies, Naeem Haider, Zhipeng Lou, Chengyu Li
Flapping Dynamics And Wing Flexibility Enhance Odor Detection In Blue Bottle Flies, Naeem Haider, Zhipeng Lou, Chengyu Li
Faculty Scholarship
One of the most ancient and evolutionarily conserved behaviors in the animal kingdom involves utilizing wind-borne odor plumes to track essential elements such as food, mates, and predators. Insects, particularly flies, demonstrate a remarkable proficiency in this behavior, efficiently processing complex odor information encompassing concentrations, direction, and speed through their olfactory system, thereby facilitating effective odor-guided navigation. Recent years have witnessed substantial research explaining the impact of wing flexibility and kinematics on the aerodynamics and flow field physics governing the flight of insects. However, the relationship between the flow field and olfactory functions remains largely unexplored, presenting an attractive frontier …
Anti-Adamts13 Autoantibodies In Immune-Mediated Thrombotic Thrombocytopenic Purpura, Robert W. Maitta
Anti-Adamts13 Autoantibodies In Immune-Mediated Thrombotic Thrombocytopenic Purpura, Robert W. Maitta
Faculty Scholarship
Autoantibodies to ADAMTS13 are at the center of pathology of the immune-mediated thrombotic thrombocytopenic purpura. These autoantibodies can be either inhibitory (enzymatic function) or non-inhibitory, resulting in protein depletion. Under normal physiologic conditions, antibodies are generated in response to foreign antigens, which can include infectious agents; however, these antibodies may at times cross-react with self-epitopes. This is one of the possible mechanisms mediating formation of anti-ADAMTS13 autoantibodies. The process known as “antigenic mimicry” may be responsible for the development of these autoantibodies that recognize and bind cryptic epitopes in ADAMTS13, disrupting its enzymatic function over ultra large von Willebrand factor …
Antipsychotic-Induced Weight Gain: What Have We Learned?, Akshatha Silas, Margaret Musso, Trygve Dolber
Antipsychotic-Induced Weight Gain: What Have We Learned?, Akshatha Silas, Margaret Musso, Trygve Dolber
Faculty Scholarship
Purpose and Scope of Review: We discuss updates in the weight gain risk stratification of various atypical antipsychotics, dose-dependency effects, the role of the gut microbiome in the mechanism of AWIG, and the potential of GLP-1 receptor agonists and antipsychotic switching in managing and mitigating the adverse effect of weight gain. These updates are organized into 3 sections: Prediction, Mechanism, and Treatment. Recent Findings: Different atypical antipsychotics are associated with different risk profiles for weight gain, and switching from higher to lower risk antipsychotics is a promising direction for mitigating this adverse effect. Other treatments that target weight gain in …
Human Mesenchymal Stem Cell Therapy: Potential Advances For Reducing Cystic Fibrosis Infection And Organ Inflammation, Tracey L. Bonfield, Hillard M. Lazarus
Human Mesenchymal Stem Cell Therapy: Potential Advances For Reducing Cystic Fibrosis Infection And Organ Inflammation, Tracey L. Bonfield, Hillard M. Lazarus
Faculty Scholarship
Innovation in cystic fibrosis (CF) supportive care, including implementing new antimicrobial agents, improved physiotherapy, and highly effective modulators therapy, has advanced patient survival into the 4th and 5th decades of life. However, even with these remarkable improvements in therapy, CF patients continue to suffer from pulmonary infection and other visceral organ complications associated with long-term deficient cystic fibrosis transmembrane conductance regulator (CFTR) expression. Human mesenchymal stem cells (MSCs) have been utilized in tissue engineering based upon their capacity to provide structural components of mesenchymal tissues. An alternative role of MSCs, however is their versatile utilization as cell-based infusion powerhouses due …
Error-Based Dynamic Velocity Range Of Piv Processing Algorithms, Gauresh Raj Jassal, Bryan E. Schmidt
Error-Based Dynamic Velocity Range Of Piv Processing Algorithms, Gauresh Raj Jassal, Bryan E. Schmidt
Faculty Scholarship
The ability of PIV processing algorithms to accurately determine velocity vectors across the range of motion present in PIV images is characterized by the algorithm’s dynamic velocity range (DVR). Conventionally, the DVR of PIV is defined using the ratio between the maximum and minimum resolvable particle displacements, with the minimum based on the uncertainty in the location of a single particle in the optical system. In this work, it is demonstrated that this definition is inadequate in practice, as it ignores many factors which affect the accuracy of an algorithm when determining small displacements, and the error in vectors with …
Teaching Around Generative Ai Plagiarism Risks, Nancy C. Marcus
Teaching Around Generative Ai Plagiarism Risks, Nancy C. Marcus
Faculty Scholarship
Much has been written and said about generative AI's potential uses and misuses by lawyers and law students in the past year. This essay does not rehash the many ongoing discourses about whether, how, and to what extent generative AI (GenAI) can be used for and taught in legal writing courses. Rather, this essay is written under the assumption that, at least to some extent early on in the law school experience, some professors don't want 1L legal writing students using GenAI to draft legal memoranda and briefs for them. As the American Bar Association's Formal Ethics Opinion 512 warns, …
Heterogeneity Of Layer 1 Interneurons In The Mouse Medial Prefrontal Cortex, Chen Shen, Wanpeng Cui, Wen Cheng Xiong, Lin Mei
Heterogeneity Of Layer 1 Interneurons In The Mouse Medial Prefrontal Cortex, Chen Shen, Wanpeng Cui, Wen Cheng Xiong, Lin Mei
Faculty Scholarship
Cortical Layer 1 (L1) acts as a critical relay for processing long-range inputs. GABAergic inhibitory interneurons (INs) in this layer (Layer 1 interneurons [L1INs]) function as inhibitory gates, regulating these inputs and modulating the activity of deeper cortical layers. However, their characteristics and circuits in the medial prefrontal cortex (mPFC) remain poorly understood. Using biocytin labeling, we identified three distinct morphological types of mPFC L1INs: neurogliaform cells (NGCs), elongated NGCs (eNGCs), and single-bouquet cell-like (SBC-like) cells. Whole-cell recordings revealed distinct firing patterns across these subtypes: NGCs and eNGCs predominantly exhibited late-spiking (LS) patterns, and SBC-like cells displayed a higher prevalence …
Pirfenidone Delivery By Blow-Molded Pcl Nanofiber Mat To Reduce Collagen Synthesis By Fibroblasts, Maximilian Zernic, Maryo Kohen, Faruk H. Orge, Amel Ahmed, Ozan Akkus
Pirfenidone Delivery By Blow-Molded Pcl Nanofiber Mat To Reduce Collagen Synthesis By Fibroblasts, Maximilian Zernic, Maryo Kohen, Faruk H. Orge, Amel Ahmed, Ozan Akkus
Faculty Scholarship
Elevated intraocular pressure (IOP) during glaucoma is sometimes mitigated by insertion of glaucoma drainage devices (GDD). Excessive fibrosis around GDD plates may confine drainage and requiring revision surgeries in some patients. Pirfenidone (PFD) is an FDA approved drug to treat lung fibrosis, and it may be effective in limiting capsule formation around the GDD. To enable this, we aimed to develop a polymeric GDD encasement sheath that can sustainably release PFD to reduce fibrous capsule formation. The PFD-doped sheath was manufactured by blow molding of (poly)caprolactone (PCL). We investigated the effects of PCL concentration, spray distance, and molecular weight on …
Plasmonic Enhancement Of Photothermal Conversion Efficiency In Gold-Nanoparticle Hydrogels, Mai S. Rashwan, Abed M. Al-Sheikh, Harihara Baskaran, Clemens Burda
Plasmonic Enhancement Of Photothermal Conversion Efficiency In Gold-Nanoparticle Hydrogels, Mai S. Rashwan, Abed M. Al-Sheikh, Harihara Baskaran, Clemens Burda
Faculty Scholarship
This study investigates the photothermal properties of citrate-capped gold nanoparticles (Au NPs) dispersed in agarose gel, examining various sizes and concentrations, particularly within a low-concentration range (0.2–2.5 nM). Heat transfer measurements are conducted on Au NP hydrogels using laser-light induced heating, revealing a size- and concentration-dependent temperature increase compared to the plain agarose gel matrix. Experimental data, combined with finite-element analysis, demonstrate that photothermal energy conversion efficiencies are dependent on NP size and concentration, while the thermal conductivity (TC) of all Au NP hydrogels remains constant and independent of these parameters within the tested concentration range. UV-visible spectroscopy indicates that …
Psychosocial Burden And Suicidality In Epilepsy: A Public Health Concern, Martha Sajatovic
Psychosocial Burden And Suicidality In Epilepsy: A Public Health Concern, Martha Sajatovic
Faculty Scholarship
The increased risk for psychosocial burden and suicidality in people with epilepsy compared to the general population is a well-established global public health concern. Suicidality risk is also increased in patients with functional seizures. The timely identification of patients at highest risk for psychosocial burden and self-harm is vital. This can pose a significant challenge for multidisciplinary clinicians caring for people with epilepsy. Early identification of social stressors and comorbid psychiatric contributors via screening are required to assist with the development of predictive models for self-harm in epilepsy; and subsequent options for treatment and the provision of adjunct supports in …
Examination Of Protective Factors That Promote Prosocial Skill Development Among Children Exposed To Intimate Partner Violence, Megan R. Holmes, Anna E. Bender, Kristen A. Berg, Kylie E. Evans, Amy Korsch-Williams, Adam T. Perzynski
Examination Of Protective Factors That Promote Prosocial Skill Development Among Children Exposed To Intimate Partner Violence, Megan R. Holmes, Anna E. Bender, Kristen A. Berg, Kylie E. Evans, Amy Korsch-Williams, Adam T. Perzynski
Faculty Scholarship
This retrospective cohort study examined prosocial skills development in child welfare-involved children, how intimate partner violence (IPV) exposure explained heterogeneity in children's trajectories of prosocial skill development, and the degree to which protective factors across children's ecologies promoted prosocial skill development. Data were from 1,678 children from the National Survey of Child and Adolescent Well-being I, collected between 1999 and 2007. Cohort-sequential growth mixture models were estimated to identify patterns of prosocial skill development between the ages of 3 to 10 years. Four diverse pathways were identified, including two groups that started high (high subtle-decreasing; high decreasing-to-increasing) and two groups …
Human-Ai Collaboration In Writing: A Multidimensional Framework For Creative And Intellectual Authorship, James Hutson
Human-Ai Collaboration In Writing: A Multidimensional Framework For Creative And Intellectual Authorship, James Hutson
Faculty Scholarship
The integration of AI technologies into the writing process has significantly altered traditional notions of authorship, creativity, and intellectual labor. Historically, writing was seen as a human-driven cognitive and creative exercise, but with the rise of generative AI tools such as ChatGPT and Claude, the line between human and AI contributions has become increasingly ambiguous. This paper addresses the limitations of the current sliding scale model, which views AI involvement as ranging from “none” to “complete”. In its place, we propose a new multidimensional framework that more accurately reflects the complexity of human-AI collaboration in writing. The model includes axes …
Development Of A Self-Management Tool For Individuals With Seizure Clusters: Trial Design And Methodological Report, Molly Mcvoy, Eytan Hirsch, Luisa Londono, Kari Colón-Zimmermann, Jin Seok Cho, Evelyn K. Shih, Martha Sajatovic
Development Of A Self-Management Tool For Individuals With Seizure Clusters: Trial Design And Methodological Report, Molly Mcvoy, Eytan Hirsch, Luisa Londono, Kari Colón-Zimmermann, Jin Seok Cho, Evelyn K. Shih, Martha Sajatovic
Faculty Scholarship
Background: Despite advances in anti-seizure medications (ASMs) for people with epilepsy (PWE), adverse outcomes, negative health events (NHEs), and breakthrough seizures remain common. Rescue medication (RM) can better manage repetitive seizures, but barriers to RM use persist. Self-management for PWE and a history of NHEs (SMART) is an evidence-based epilepsy self-management program aimed at reducing barriers and maximizing facilitators to self-care in high-risk PWE. Methods: This 2-phase, ongoing clinical trial adapts SMART to integrate RM support for PWE with repetitive seizures. Phase 1, now completed, used input from an advisory board (AB) of PWE, caregivers, and clinicians to adapt the …
Prevalence Of Social Determinants Of Health Risk Factors Among And Their Impact On Viral Suppression, Consistent Visits, And No-Show Rates Among Persons With Hiv Who Identify As Hispanic, Mary Cowden, Ana Clavijo, Pragnya Iyengar, Ann Avery
Prevalence Of Social Determinants Of Health Risk Factors Among And Their Impact On Viral Suppression, Consistent Visits, And No-Show Rates Among Persons With Hiv Who Identify As Hispanic, Mary Cowden, Ana Clavijo, Pragnya Iyengar, Ann Avery
Faculty Scholarship
The current study examines the association between language preference, social determinants of health (SDOH) risk factors, viral load, and HIV care outcomes among individuals of Hispanic ethnicity in the United States. More than half (54%) of all participants reported having two or more unmet needs. Hispanic individuals were more likely to be at risk in 2 or more domains than their non-Hispanic counterparts. Food insecurity was the most common risk factor reported and when present, 51% of patients also reported financial resource strain. Surprisingly, when language preference was analyzed, English-preferring Hispanic patients were at higher risk of financial resource strain, …
Postnatal Progressive Craniosynostosis: An Unusual Case Presentation Leading To Cascade Diagnosis For Multiple Generations, Jessica T. Ogawa, Maura Guyler, Krystal L. Tomei, Howard D. Wang
Postnatal Progressive Craniosynostosis: An Unusual Case Presentation Leading To Cascade Diagnosis For Multiple Generations, Jessica T. Ogawa, Maura Guyler, Krystal L. Tomei, Howard D. Wang
Faculty Scholarship
NM_000141.5: FGFR2 c.1032G>A is a pathogenic variant that causes Crouzon syndrome through activation of a new donor splice site. This clinical report highlights the intrafamilial variability that can exist with this specific variant. The proband is a 4-year-old boy who initially presented with concern for seizures. Computed tomography and magnetic resonance imaging revealed pancraniosynostosis and Chiari 1 malformation. Papilledema on fundoscopic exam and copper beaten appearance of the skull on imaging both suggested the presence of elevated intracranial pressure. Genetic testing identified c.1032G>A (p.Ala344=) in FGFR2. Familial testing and genetic evaluation confirmed the same pathogenic variant in the …
Performing Protest, Performing Memory: Speech Act Theory And January 6, Mary Lynne Gasaway Hill
Performing Protest, Performing Memory: Speech Act Theory And January 6, Mary Lynne Gasaway Hill
Faculty Scholarship
In daily life, memory performs a staggering array of tasks. It offers reassurance, validation, legitimation, and approval. It transgresses boundaries and polices them. It confirms understandings and undermines them. It warms our hearts and chills our blood. In the realm of protest, as this article will show, memory works through intentional language use. In the context of activism, acts of memory are often performative: they aim not just to restate the status quo, but to change something about it. This chapter operationalises J.L. Austin’s Speech Act Theory (1994, SAT) as a lens through which to examine how the contentious discourse …
Examining The Relationship Between Frailty, Operative Management, And 90-Day Mortality Across Emergency General Surgery Conditions, Caleb W. Curry, Marisa R. Imbroane, Wyatt P. Bensken, Adam T. Perzynski, Christopher W. Towe, Vanessa P. Ho
Examining The Relationship Between Frailty, Operative Management, And 90-Day Mortality Across Emergency General Surgery Conditions, Caleb W. Curry, Marisa R. Imbroane, Wyatt P. Bensken, Adam T. Perzynski, Christopher W. Towe, Vanessa P. Ho
Faculty Scholarship
No abstract provided.
Scalability Of A Graph Neural Network In Accurate Prediction Of Frictional Contact Networks In Suspensions, Armin Aminimajd, Joao Maia, Abhinendra Singh
Scalability Of A Graph Neural Network In Accurate Prediction Of Frictional Contact Networks In Suspensions, Armin Aminimajd, Joao Maia, Abhinendra Singh
Faculty Scholarship
Dense suspensions often exhibit shear thickening, characterized by a dramatic increase in viscosity under large external forcing. This behavior has recently been linked to the formation of a system-spanning frictional contact network (FCN), which contributes to increased resistance during deformation. However, identifying these frictional contacts poses experimental challenges and is computationally expensive. This study introduces a graph neural network (GNN) model designed to accurately predict FCNs by two dimensional simulations of dense shear thickening suspensions. The results demonstrate the robustness and scalability of the GNN model across various stress levels (s), packing fractions (f), system sizes, particle size ratios (D), …
Aging Is Associated With Decreased Lactobacillus And Increased Cervicovaginal Inflammation In Canadian Women, Ha T. Dang, Laura Noel-Romas, Samantha Knodel, Kenzie Birse, Hossaena Ayele, Alicia R. Berard, Adam D. Burgener, Christina Farr Zuend
Aging Is Associated With Decreased Lactobacillus And Increased Cervicovaginal Inflammation In Canadian Women, Ha T. Dang, Laura Noel-Romas, Samantha Knodel, Kenzie Birse, Hossaena Ayele, Alicia R. Berard, Adam D. Burgener, Christina Farr Zuend
Faculty Scholarship
Problem: Aging is characterized by a general dysregulation of systemic immune responses that increases susceptibility to infections and malignancies. Immune cells in the female genital tract (FGT) are regulated by sex hormones, but little is known about the impact of aging and menopause on immunology in the FGT. Method of Study: This study conducted an age-focused sub-analysis of cervicovaginal samples collected from 47 women enrolled in the Vaginal Mucosal Systems study in Winnipeg, Canada. Paired cervicovaginal lavage and cervical cytobrush were collected and analyzed by Luminex cytokine array, mass spectrometry based metaproteomics, metabolomics, and high dimensional flow cytometry. Results: The …
Redefining Cell Culture Using A 3d Flipwell Co-Culture System: A Mimetic For Gut Architecture And Dynamics In Vitro, Saori Furuta
Redefining Cell Culture Using A 3d Flipwell Co-Culture System: A Mimetic For Gut Architecture And Dynamics In Vitro, Saori Furuta
Faculty Scholarship
Gut mucosae are composed of stratified layers of microbes, a selectively permeable mucus, an epithelial lining, and connective tissue homing immune cells. Studying cellular and chemical interactions between the gut mucosal components has been limited without a good model system. We have engineered a three-dimensional (3D) multi-cellular co-culture system we coined “3D Flipwell system” using cell culture inserts stacked against each other. This system allows an assessment of the impact of a gut mucosal environmental change on interactions between gut bacteria, epithelia, and immune cells. As such, this system can be utilized in examining the effects of exogenous stimuli, such …
Super-Resolution Imaging Reveals Resistance To Mass Transfer In Functionalized Stationary Phases, Ricardo Monge Neria, Muhammad Zeeshan, Aman Kapoor, Tae Kyong John Kim, Nichole Hoven, Jeffrey Pigott, Burcu Gurkan, Christine Duval, Lydia Kisley
Super-Resolution Imaging Reveals Resistance To Mass Transfer In Functionalized Stationary Phases, Ricardo Monge Neria, Muhammad Zeeshan, Aman Kapoor, Tae Kyong John Kim, Nichole Hoven, Jeffrey Pigott, Burcu Gurkan, Christine Duval, Lydia Kisley
Faculty Scholarship
Chemical separations are costly in terms of energy, time, and money. Separation methods are optimized with inefficient trial-and-error approaches that lack insight into the molecular dynamics that lead to the success or failure of a separation and, hence, ways to improve the process. We perform super-resolution imaging of fluorescent analytes in five different commercial liquid chromatography materials. Unexpectedly, we observe that chemical functionalization can block more than 50% of the material’s porous interior, rendering it inaccessible to small-molecule analytes. Only in situ imaging unveils the inaccessibility when compared to the industry-accepted ex situ characterization methods. Selectively removing some of the …
Super-Resolution Imaging Reveals Resistance To Mass Transfer In Functionalized Stationary Phases, Ricardo Monge Neria, Muhammad Zeeshan, Aman Kapoor, Tae Kyong John Kim, Nichole Hoven, Jeffrey S. Pigott, Burcu Gurkan, Christine E. Duval, Lydia Kisley
Super-Resolution Imaging Reveals Resistance To Mass Transfer In Functionalized Stationary Phases, Ricardo Monge Neria, Muhammad Zeeshan, Aman Kapoor, Tae Kyong John Kim, Nichole Hoven, Jeffrey S. Pigott, Burcu Gurkan, Christine E. Duval, Lydia Kisley
Faculty Scholarship
Chemical separations are costly in terms of energy, time, and money. Separation methods are optimized with inefficient trial-and-error approaches that lack insight into the molecular dynamics that lead to the success or failure of a separation and, hence, ways to improve the process. We perform super-resolution imaging of fluorescent analytes in five different commercial liquid chromatography materials. Unexpectedly, we observe that chemical functionalization can block more than 50% of the material’s porous interior, rendering it inaccessible to small-molecule analytes. Only in situ imaging unveils the inaccessibility when compared to the industry-accepted ex situ characterization methods. Selectively removing some of the …
Towards More Sustainable Oceans: A Review Of The Pressing Challenges Posed By Marine Plastic Litter, Peter Yang
Towards More Sustainable Oceans: A Review Of The Pressing Challenges Posed By Marine Plastic Litter, Peter Yang
Faculty Scholarship
Marine littering is a global challenge and a significant threat to a sustainable planet, requiring comprehensive and effective mechanisms to address it in a comprehensive manner. This study reports on a bibliometric analysis that has identified the extent to which the topic has been explored in the international literature, by focusing on geographical scope, the emphasis on (micro)plastic litter and on policy measures. Additionally, as a complement to the assessment of the recent literature on marine plastic litter, this study reviews some case studies, identifying some trends on how to cope with this problem. The findings underscore the imperative for …