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Articles 241 - 270 of 6488
Full-Text Articles in Entire DC Network
Surface-Electromyography Characteristics Of Clonic Seizures With No Scalp-Eeg Correlate: A Comparative Analysis With Tremors, Akshaya R. Sivaji, Shwetank Singh, Zachary Scicchitano, Roohi Katyal, Neel Fotedar
Surface-Electromyography Characteristics Of Clonic Seizures With No Scalp-Eeg Correlate: A Comparative Analysis With Tremors, Akshaya R. Sivaji, Shwetank Singh, Zachary Scicchitano, Roohi Katyal, Neel Fotedar
Faculty Scholarship
Introduction: Clonic seizures are characterized by twitching movements at a frequency of 0.2–5 Hz. The clonic “twitch” is produced by a brief synchronized contraction of agonist and antagonist muscles, followed by a synchronized silent period. In this study, we aimed to compare the surface-electromyography (sEMG) characteristics of scalp-EEG negative clonic seizures with those of nonepileptic movements like tremors that can resemble clonic seizures. Methods: We retrospectively identified patients who were diagnosed with scalp-EEG negative clonic seizures or tremors. We only included patients (n = 6) who were monitored simultaneously with video-EEG and sEMG electrodes. sEMG was placed on agonist and …
The Diverse Roles Of Complex Glycans In Synapse Development And Function, Peng Zhang
The Diverse Roles Of Complex Glycans In Synapse Development And Function, Peng Zhang
Faculty Scholarship
Protein glycosylation is a critical post-translational modification that mediates a myriad of biological functions, including neuronal development in the brain. Stages of neuronal development include neurogenesis, neuronal migration, axonal guidance, synapse formation, and activity-dependent synaptic remodeling and plasticity. Among these, synapse formation and plasticity are essential to establish and maintain neuronal circuits for proper brain function. Yet, the physiological role of glycans at synapses remains poorly understood. This is especially true for complex glycans, known for decades to be present on the cell surface or extracellular matrix, including the microenvironment around synapses. In this review, we highlight recent examples of …
Apolipoprotein E (Apoe) And Alzheimer's Disease Risk In A Ugandan Population: A Pilot Case-Control Study, Martha Sajatovic
Apolipoprotein E (Apoe) And Alzheimer's Disease Risk In A Ugandan Population: A Pilot Case-Control Study, Martha Sajatovic
Faculty Scholarship
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by cognitive decline and progressive functional impairment. The Apolipoprotein E (APOE) gene, particularly its ϵ2, ϵ3, and ϵ4 alleles, plays a crucial role in lipid metabolism, and has been implicated in AD pathogenesis. Although the APOE ϵ4 status is associated with an increased risk of AD, its impact varies across populations. This study investigated the prevalence of and association between APOE alleles and AD risk in a Ugandan cohort. This case-control study was conducted in Uganda, and included 87 participants (45 patients with AD and 42 healthy controls). Cognitive assessment …
Congress Of Neurological Surgeons Systematic Review And Evidence-Based Guidelines For The Role Of Imaging In Newly Diagnosed Who Grade Ii Diffuse Glioma In Adults: Update, Chaitra Badve, Abraham Nirappel
Congress Of Neurological Surgeons Systematic Review And Evidence-Based Guidelines For The Role Of Imaging In Newly Diagnosed Who Grade Ii Diffuse Glioma In Adults: Update, Chaitra Badve, Abraham Nirappel
Faculty Scholarship
Target population: Adult patients with suspected or histologically proven WHO Grade II diffuse glioma. Question 1: In adult patients with suspected or histologically proven WHO Grade II diffuse glioma, do advanced MRI techniques using magnetic resonance spectroscopy, perfusion weighted imaging or diffusion weighted imaging provide superior assessment of tumor grade, margins, progression, treatment-related effects, and prognosis compared to standard neuroimaging? Recommendation: Level II: The use of diffusion imaging and dynamic susceptibility contrast (DSC), dynamic contrast enhancement (DCE) and arterial spin labeling (ASL) sequences are suggested to differentiate WHO Grade II diffuse glioma from higher grade gliomas when this is not …
On Metric Choice In Dimension Reduction For Fréchet Regression, Abdul Nasah Soale, Congli Ma, Siyu Chen
On Metric Choice In Dimension Reduction For Fréchet Regression, Abdul Nasah Soale, Congli Ma, Siyu Chen
Faculty Scholarship
Fréchet regression is becoming a mainstay in modern data analysis for analysing non-traditional data types belonging to general metric spaces. This novel regression method is especially useful in the analysis of complex health data such as continuous monitoring and imaging data. Fréchet regression utilises the pairwise distances between the random objects, which makes the choice of metric crucial in the estimation. In this paper, existing dimension reduction methods for Fréchet regression are reviewed, and the effect of metric choice on the estimation of the dimension reduction subspace is explored for the regression between random responses and Euclidean predictors. An extensive …
Predicting Sorption Of Diverse Organic Compounds In Soil-Water Systems: Meta-Analysis, Machine Learning Modeling, And Global Soil Mapping, Jiachun Sun, Kai Zhang, Huichun Zhang
Predicting Sorption Of Diverse Organic Compounds In Soil-Water Systems: Meta-Analysis, Machine Learning Modeling, And Global Soil Mapping, Jiachun Sun, Kai Zhang, Huichun Zhang
Faculty Scholarship
In recent decades, the environmental detection of various organic compounds (OCs) has highlighted the limitations of conventional soil-water sorption models, which simplify complex experimental conditions and often overlook OCs with polyfunctional and ionizable structures. To address these shortcomings, we compiled a comprehensive soil-water sorption dataset encompassing 20,945 data points for 419 OCs with various functional groups and 1037 different soils. Meta-analysis of the dataset revealed the trends of soil sorption associated with OC substructures, soil properties, and solution conditions. Machine learning models employing the XGBoost algorithm, in conjunction with MACCS fingerprints and experimental conditions, were developed to cover the entire …
Tnf-Α-Driven Changes In Polarized Egf Receptor Trafficking Facilitate Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling From The Apical Surface Of Mdck Epithelial Cells, Syntyche Ngalula, Cathleen R. Carlin
Tnf-Α-Driven Changes In Polarized Egf Receptor Trafficking Facilitate Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling From The Apical Surface Of Mdck Epithelial Cells, Syntyche Ngalula, Cathleen R. Carlin
Faculty Scholarship
This manuscript describes a novel unconventional secretory pathway that facilitates EGF receptor (EGFR) signaling from apical membranes in polarized epithelial cells responding to immune cell mediators. Epithelial tissues provide a physical barrier between our bodies and the external environment and share an intimate relationship with circulating and local immune cells. Our studies describe an unexpected connection between the proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) and EGFR typically localized to basolateral membranes in polarized epithelial cells. These two molecules sit atop complex biological networks with a long history of shared investigative interest from the vantage point of signaling pathway interactions. We …
Breaking New Ground: Division Directly In Memory, M. Hassan Najafi, Mehran Shoushtari Moghadam
Breaking New Ground: Division Directly In Memory, M. Hassan Najafi, Mehran Shoushtari Moghadam
Faculty Scholarship
In-memory computing (IMC) has emerged as a promising paradigm for overcoming the limitations of traditional von Neumann architectures by reducing data movement and enhancing computational efficiency. Despite significant advancements in this area, implementing complex arithmetic operations, such as division, directly within memory has remained an elusive challenge. This paper introduces a pioneering technique for performing division operations directly in memory, representing the first successful integration of such functionality into the IMC framework. Our approach leverages an innovative circuit based on an unconventional model of computing–stochastic computing (SC). Our technique extends the computational capabilities of IMC systems and paves the way …
The Built Environment And Adverse Cardiovascular Events In Us Veterans With Cardiovascular Disease, Skanda Moorthy, Zhuo Chen, Tong Zhang, Sai Rahul Ponnana, Santosh Kumar Sirasapalli, Kanimozhi Shivanantham, Haitham Khraishah, Jean Eudes Dazard, Sadeer G. Al-Kindi, Salil V. Deo, Sanjay Rajagopalan
The Built Environment And Adverse Cardiovascular Events In Us Veterans With Cardiovascular Disease, Skanda Moorthy, Zhuo Chen, Tong Zhang, Sai Rahul Ponnana, Santosh Kumar Sirasapalli, Kanimozhi Shivanantham, Haitham Khraishah, Jean Eudes Dazard, Sadeer G. Al-Kindi, Salil V. Deo, Sanjay Rajagopalan
Faculty Scholarship
Question: Can AI-extracted interpretable built environment features predict major adverse cardiovascular events (MACE) in a national veteran population? Findings: In this cohort study of 770,990 U.S. veterans, seven built environment features were significantly associated with an increased risk of MACE. Two features, old/dilapidated buildings and visible wire, were associated with a decreased risk. Greenery was only linked to increased risk in higher social deprivation index quartiles. Meaning: Built environment features can serve as predictors of MACE, highlighting the potential role of neighborhood characteristics in cardiovascular risk stratification beyond traditional factors. Importance: The relationship between built environment features and major adverse …
Role Of Fluid-Structure Interactions In Mechanosensation During Hovering Flapping Flight, Menglong Lei, Chengyu Li
Role Of Fluid-Structure Interactions In Mechanosensation During Hovering Flapping Flight, Menglong Lei, Chengyu Li
Faculty Scholarship
Insect wings, known for their intricate structure and function, inherently deform during flapping motion. These deformations can be classified into chordwise cambering, spanwise bending, and root-to-tip twisting, arising from non-uniform venation distribution, aerodynamic loading, and wing inertia. Crucially, such deformations play a vital role in enhancing both aerodynamic performance and mechanosensory function. To investigate the complex interplay between wing structure, unsteady aerodynamics, and mechanosensation, we developed a fully coupled three-dimensional fluid-structure interaction (FSI) solver. This framework integrates an in-house Navier-Stokes equations solver for resolving the flow field with the open-source Vega FEM code to solve the solid structure dynamics. Our …
A Continuous-Heat-Flux Phase Change Model For Simulating Realistic Two-Phase Unsaturated Evaporation Processes, Thanh Hoang Phan, Cho Ning Huang, Chirag R. Kharangate
A Continuous-Heat-Flux Phase Change Model For Simulating Realistic Two-Phase Unsaturated Evaporation Processes, Thanh Hoang Phan, Cho Ning Huang, Chirag R. Kharangate
Faculty Scholarship
Accurately modeling liquid-vapor mass transfer rates is essential for optimizing cryogenic fluid management processes critical to advancing future space missions. This study introduces a continuous-heat-flux phase change model proposed to simulate conditions observed in realistic two-phase unsaturated evaporation phenomena. The mass transfer rate across the two-phase interface is calculated directly based on the local interfacial continuous heat flux on both liquid and vapor phases, effectively accounting for superheated, saturated, and subcooled liquid effects without requiring any empirical tuning parameters. Moreover, phase change occurs exclusively within interfacial cells, ensuring the sharp representation of deformed evaporating interfaces with high accuracy. The proposed …
Eviction Sealing: A Lifeline In The Fight For Housing Justice, Allison Freedman
Eviction Sealing: A Lifeline In The Fight For Housing Justice, Allison Freedman
Faculty Scholarship
In January 2023, the White House released a Blueprint for a Renters Bill of Rights. The Blueprint called for immediate sealing of eviction case filings to reduce the likelihood that tenants would be locked out of future housing opportunities without the chance to defend themselves. Shortly thereafter, the Federal Trade Commission and the Consumer Financial Protection Bureau issued a request for public comment on how the use of eviction records and screening algorithms may affect tenant housing opportunities and drive discriminatory outcomes. The eviction crisis, its discriminatory effects, and the idea that sealing eviction records may provide a solution to …
The "Not Seen" Effect Of International Financial Centers: Innovation In The Global Financial Ecosystem, Charlotte Ku, Andrew P. Morriss
The "Not Seen" Effect Of International Financial Centers: Innovation In The Global Financial Ecosystem, Charlotte Ku, Andrew P. Morriss
Faculty Scholarship
International Financial Centers (IFCs) are hubs of legal and financial innovation, developing specialized frameworks that facilitate cross-border investment, enhance global capital mobility, and support economic growth. Through jurisdictional competition, professional clustering, and adaptive regulatory frameworks, IFCs have pioneered legal structures that enable enterprises of all sizes to participate in the global economy. Using case studies of the International Business Company, the Limited Liability Company, the Protected Cell Company, and advances in trust law and applying the theoretical frameworks of social scientist Richard Florida and psychologist Mihalyi Csikszentmihalyi, this Article illustrates how IFCs serve as laboratories for financial experimentation, generating widely …
Law And Political Economy: Missing Markets, Missing Law, And Missing Political Economy, Andrew P. Morriss, Roger E. Meiners
Law And Political Economy: Missing Markets, Missing Law, And Missing Political Economy, Andrew P. Morriss, Roger E. Meiners
Faculty Scholarship
This Article critiques the "Law and Political Economy" (LPE) framework. It aims to challenge the Law and Economics (L&E) approach. We argue that LPE lacks a coherent theoretical foundation and fails to engage with empirical evidence, rendering its critiques of markets, law, and political economy incomplete and unpersuasive. By contrast, L&E provides robust analytical tools and a well-developed understanding of legal and market dynamics, is grounded in empirical research, and has theoretical consistency. We illustrate these points through historical examples in the evolution of L&E and suggest ways LPE can evolve to offer a meaningful alternative. Rigorous intellectual competition will …
1785 Parisian Salon Project: New Methods And Practical Innovations In Digital Heritage Reconstruction, James Hutson, Charles O'Brien, Wesley Wolfe, Kayla Kraff, Trent Olsen
1785 Parisian Salon Project: New Methods And Practical Innovations In Digital Heritage Reconstruction, James Hutson, Charles O'Brien, Wesley Wolfe, Kayla Kraff, Trent Olsen
Faculty Scholarship
The 1785 Salon Unreal Engine Reconstruction Project represents a significant advance in digital heritage and immersive art historical research by combining generative AI-based asset creation, modular user experience (UX) design, and historically informed workflows. During the Spring 2025 phase, the project achieved major milestones, including the successful development of a replicable pipeline for transforming 2D reference images into period-accurate 3D sculpture models using generative AI and digital sculpting tools. Simultaneously, a robust and adaptable Inspection System was engineered within Unreal Engine, offering granular interaction controls, bilingual (English/French) content integration, dynamic metadata display, and enhanced accessibility. These innovations collectively enabled historically …
The Right To Grow Old, Jamal Greene
The Right To Grow Old, Jamal Greene
Faculty Scholarship
This chapter considers the status of a constitutional “right to grow old” under the US Constitution. Understood as a “positive” right – ensuring a certain minimum quality of life to people as they face the challenges of aging – such a right may seem unavailing given the austerity in respect to such rights that many lawyers associate with the US constitutional tradition. This chapter shows this view to be premature, at least. Unlike the kinds of positive rights overtly rejected in prior cases, such as rights to certain forms of social welfare or to racial equality, a right to grow …
Current Standards And Future Directions Of Duchenne Muscular Dystrophy Respiratory Care: The Ppmd Italy Meeting Report, Jane Black, David J. Birnkrant
Current Standards And Future Directions Of Duchenne Muscular Dystrophy Respiratory Care: The Ppmd Italy Meeting Report, Jane Black, David J. Birnkrant
Faculty Scholarship
Objective: This report summarizes key discussions from the meeting “Current Standards and Future Directions of Respiratory Assessment and Management of Duchenne Muscular Dystrophy (DMD),” organized by Parent Project Muscular Dystrophy (PPMD) Italy and the United States to address current challenges and opportunities in DMD respiratory care. Methods: The meeting brought together researchers, clinicians, and patient advocates who shared experiences, discussed advancements in DMD respiratory management, and identified areas of debate that require further research. Results: The speakers emphasized routine assessment of pulmonary function and of breathing during sleep to achieve timely diagnosis of respiratory complications. Therapeutic discussions focused on airway …
Letter To The Fda Proposing Major Changes In The Us Clozapine Package Insert Supported By Clozapine Experts Worldwide. Part I A Review Of The Pharmacokinetic Literature And Proposed Changes, Martha Sajatovic
Faculty Scholarship
Purpose/Background: Clozapine was approved in the United States (US) using 1989 regulations and knowledge. After 30 years, many sections of the US package insert (PI) are outdated. Methods: We comprehensively reviewed the literature to propose PI updates. We present the information in 2 articles. In Part I, we focus on basic pharmacology based on 407 relevant articles. Part II focuses on clinical aspects and pharmacovigilance. Findings/Results: Based on more recent expectations of Food and Drug Administration regulations, we reviewed clozapine basic pharmacology including the following: 1) clearance, 2) pharmacokinetics and pharmacodynamics, and 3) monitoring tools. We identified 9 major problems …
Letter To The Fda Proposing Major Changes In The Us Clozapine Package Insert Supported By Clozapine Experts Worldwide. Part Ii A Review Of Fatal Outcomes In Us Pharmacovigilance Data And Proposed Changes, Martha Sajatovic
Faculty Scholarship
Purpose/Background: This is the second part of a 2-part article that proposes improving the United States (US) clozapine package insert. Part II focuses on fatal outcomes and the 5 boxed warnings, 4 specifically for clozapine: severe neutropenia, seizure, orthostatic hypotension and myocarditis, and 1 for all antipsychotics (elderly with dementia). Methods: US reports to the World Health Organization's global pharmacovigilance database were analyzed from clozapine's introduction to January 15, 2023. Findings/Results: The US was the top reporter worldwide for clozapine with 56,003 reports and 9587 associated fatal outcomes. The 4 clozapine boxed warnings were associated with 534 fatal outcomes (218 …
Pv Backsheets Survey Protocol: A Framework For Geo-Spatial Field Surveys For Bulk Material Characterization And Reliability Analysis Applied Across 41 Pv Systems, Raymond J. Wieser, Zelin Li, Xuanji Yu, Laura S. Bruckman
Pv Backsheets Survey Protocol: A Framework For Geo-Spatial Field Surveys For Bulk Material Characterization And Reliability Analysis Applied Across 41 Pv Systems, Raymond J. Wieser, Zelin Li, Xuanji Yu, Laura S. Bruckman
Faculty Scholarship
As widespread adoption of photovoltaic (PV) technologies continues, understanding the lifetime of modules is paramount to the viability of the industry as an environmentally conscious alternative to traditional energy generation. Although power degradation can affect the total energy production of a module over its lifetime, module safety failures necessitate the removal of a module leading to a loss of not only the particular asset, but the earning potential of the device. Therefore, it is critical to ensure that the components that provide essential safety functions for PV module operate for their entire rated lifetime. PV backsheets provide necessary electrical insulation …
Non-Finite Clause Use In Disciplinary Research Writing: A Formulaic Sequence-Based Functional Comparison Between Expert And Student Writers, Xixin Qiu
Faculty Scholarship
Non-finite clauses (NFCs), despite their increasingly recognized role in second language (L2) acquisition and academic writing as part of a multidimensional conceptualization of syntactic complexity, have not been analyzed in functional and discipline-specific perspectives. This study addresses this gap by providing a linguistic-descriptive account of NFC use in expert and advanced student English research writing. Using a 2.26-million-word corpus of published research articles and student manuscripts in Agricultural Science, this study profiles the distribution of NFC subtypes and identifies frequent discoursal functions realized by non-finite verb-centered formulaic sequences. The findings reveal significant differences in NFC use across writer groups, with …
Thrombotic Thrombocytopenic Purpura In Pediatric Patients, Niki Shrestha, Robert W. Maitta
Thrombotic Thrombocytopenic Purpura In Pediatric Patients, Niki Shrestha, Robert W. Maitta
Faculty Scholarship
Thrombotic thrombocytopenia purpura is a serious disease that can involve complex symptomatology, prolonged hospitalization, and a high risk of mortality if treatment is delayed. This disease is rare, but it is even rarer among pediatric patients. Even though it was first described 100 years ago, the earliest documented case was a pediatric patient. The last three decades have seen the discovery of the pathological mechanisms responsible for its clinical presentation. Symptoms/signs characteristic of microangiopathic hemolytic anemia with significant thrombocytopenia characterize the vast majority of patients. Its pathology centers on the accumulation of ultra-large von Willebrand factor multimers due to an …
Capturing Interfacial Phase Change And Flow Physics During Vertical Downflow Condensation, Thanh Hoang Phan, Cho Ning Huang, Chirag R. Kharangate
Capturing Interfacial Phase Change And Flow Physics During Vertical Downflow Condensation, Thanh Hoang Phan, Cho Ning Huang, Chirag R. Kharangate
Faculty Scholarship
Two-phase configurations can address the urgent demand for effective heat dissipation solutions in Naval power and energy systems. A better understanding of thermal transport processes in phase-change flows is critical for developing novel two-phase design tools for naval scientists and engineers. This study investigates interfacial phase change and flow dynamics during condensation flow through numerical simulations. An enhanced phase change model, incorporating a mass transfer intensity coefficient dependent on condensation film thickness, is implemented for vertical downflow condensation. A two-dimensional homogeneous two-phase Reynolds-Averaged Navier-Stokes model, coupled with the Shear-Stress Transport k-ω turbulence model, is employed. The developed solver is thoroughly …
Evaluation Of Objective Methods For Analyzing Ipsilateral Motor Evoked Potentials In Stroke Survivors With Chronic Upper Extremity Motor Impairment, Xin Li, Jayme S. Knutson, Xiaofeng Wang, Ken Uchino, Ela B. Plow, David A. Cunningham
Evaluation Of Objective Methods For Analyzing Ipsilateral Motor Evoked Potentials In Stroke Survivors With Chronic Upper Extremity Motor Impairment, Xin Li, Jayme S. Knutson, Xiaofeng Wang, Ken Uchino, Ela B. Plow, David A. Cunningham
Faculty Scholarship
Objective. Ipsilateral motor evoked potentials (iMEPs) are believed to represent cortically evoked excitability of uncrossed brainstem-mediated pathways. In the event of extensive injury to (crossed) corticospinal pathways, which can occur following a stroke, uncrossed ipsilateral pathways may serve as an alternate resource to support the recovery of the paretic limb. However, iMEPs, even in neurally intact people, can be small, infrequent, and noisy, so discerning them in stroke survivors is very challenging. This study aimed to investigate the inter-rater reliability of iMEP features (presence/absence, amplitude, area, onset, and offset) to evaluate the reliability of existing methods for objectively analyzing iMEPs …
Characterization Of The Gut Microbiome In Alzheimer Disease And Mild Cognitive Impairment Among Older Adults In Uganda: A Case-Control Study, Martha Sajatovic, Scott M. Williams
Characterization Of The Gut Microbiome In Alzheimer Disease And Mild Cognitive Impairment Among Older Adults In Uganda: A Case-Control Study, Martha Sajatovic, Scott M. Williams
Faculty Scholarship
Alzheimer disease (AD) is associated with significant shifts in the gut microbiome and is characterized by reduced microbial diversity and changes in the abundance of specific taxa. These alterations can disrupt the gut-brain axis, leading to increased intestinal permeability ("leaky gut"), systemic inflammation, and oxidative stress. Such microbial changes are thought to contribute to neurodegenerative changes, as observed in AD and cognitive decline, thus emphasizing the role of the microbiome in aging-related neurological health. Our study in urban and rural population in Uganda recruited 104 participants aged 60 years and older, categorized into AD, mild cognitive impairment (MCI), and control …
Consensus Recommendations Regarding Local And Metastasis-Directed Therapies In The Management Of Relapsed/Recurrent Ewing Sarcoma, Shauna R. Campbell, Erin Murphy, Matteo Trucco Pediatrics
Consensus Recommendations Regarding Local And Metastasis-Directed Therapies In The Management Of Relapsed/Recurrent Ewing Sarcoma, Shauna R. Campbell, Erin Murphy, Matteo Trucco Pediatrics
Faculty Scholarship
Limited randomized or prospective data are available to guide local/metastasis directed therapy (LMDT) in relapsed/recurrent Ewing sarcoma (RR-ES), resulting in uncertainty regarding best clinical practice for these patients. This report reviews the available literature on LMDT approaches and provides consensus recommendations regarding therapeutic decision making, timing, and indications for the use of LMDT in the management of RR-ES. LMDT should be considered on a case-by-case basis to assess appropriateness, optimal timing/modality, palliative versus curative intent, and its role in relation to chemotherapy. One commonly used LMDT is radiotherapy (RT), which can be delivered through standard, hypofractionated, or stereotactic techniques based …
Glycation Metabolites Predict Incident Age-Related Comorbidities And Mortality In Older People With Hiv, Xi Qiao, Liangliang Zhang, Ming Wang
Glycation Metabolites Predict Incident Age-Related Comorbidities And Mortality In Older People With Hiv, Xi Qiao, Liangliang Zhang, Ming Wang
Faculty Scholarship
Glycation is a class of modifications arising from non-enzymatic reactions of reducing sugars with proteins, lipids, and/or DNA, generating advanced glycation end-products (AGEs). AGEs are linked to many age-related comorbidities. In response to HIV-1 infection, activated T-cells and macrophages shift their predominate metabolism from oxidative phosphorylation to glycolysis. Increased glycolytic flux enhances AGE formation, which may increase age-related comorbidities. In this prospective, multicenter cohort study of antiretroviral therapy treated people with HIV, we explored predictive associations by baseline plasma AGE concentrations and their corresponding detoxification metabolites, with incident comorbidities and mortality. AGEs included dicarbonyl sugars: 3-deoxyglucosone, glyoxal, and methylglyoxal. Methylglyoxal-derived …
Cystic Fibrosis-Related Neurodegenerative Disease Associated With Tauopathy And Cognitive Decline In Aged Cf Mice, Danica F. Patton-Parfyonov, Xinming Wang, Sarah Barker, Deborah A. Corey, Edwin Vázquez-Rosa, Nichele Abeyesundere, Whitney M. Ward, Rebecca Darrah, Jung A. Woo, David E. Kang, Andrew A. Pieper, Thomas J. Kelley
Cystic Fibrosis-Related Neurodegenerative Disease Associated With Tauopathy And Cognitive Decline In Aged Cf Mice, Danica F. Patton-Parfyonov, Xinming Wang, Sarah Barker, Deborah A. Corey, Edwin Vázquez-Rosa, Nichele Abeyesundere, Whitney M. Ward, Rebecca Darrah, Jung A. Woo, David E. Kang, Andrew A. Pieper, Thomas J. Kelley
Faculty Scholarship
Background: Highly effective modulator therapies (HEMT) are increasing the lifespan for many people with cystic fibrosis (pwCF), making it necessary to identify and understand CF specific age-related consequences. In this study, we examine the impact of aging on cognitive function and age-related brain pathology in a CF mouse model focusing on phospho-Tau (pTau) pathology. Methods: Cognitive function was measured by novel object recognition and spontaneous alternation behavior tests. Hippocampal neuronal function was assessed by measuring long-term potentiation (LTP) electrophysiology, the synaptic correlate of learning and memory. Tau pathology was assessed by immunohistochemical analyses and western blot assessment of pTau levels …
Materials Data Science Ontology(Mds-Onto): Unifying Domain Knowledge In Materials And Applied Data Science, Balashanmuga Priyan Rajamohan, Alexander C. Harding Bradley, Van D. Tran, Jonathan E. Gordon, Hayden W. Caldwell, Redad Mehdi, Gabriel Ponon, Quynh D. Tran, Ozan Dernek, Benjamin G. Pierce, Raymond Wieser, Weiqi Yue, Kiefer Lin, Jiana Kambo, Arafath Nihar, Pawan K. Tripathi, Yinghui Wu, Laura S. Bruckman, Erika I. Barcelos, Roger H. French
Materials Data Science Ontology(Mds-Onto): Unifying Domain Knowledge In Materials And Applied Data Science, Balashanmuga Priyan Rajamohan, Alexander C. Harding Bradley, Van D. Tran, Jonathan E. Gordon, Hayden W. Caldwell, Redad Mehdi, Gabriel Ponon, Quynh D. Tran, Ozan Dernek, Benjamin G. Pierce, Raymond Wieser, Weiqi Yue, Kiefer Lin, Jiana Kambo, Arafath Nihar, Pawan K. Tripathi, Yinghui Wu, Laura S. Bruckman, Erika I. Barcelos, Roger H. French
Faculty Scholarship
Ontologies have gained popularity in the scientific community as a way to standardize terminologies in organizations’ data. Although certain cohorts have created frameworks with rules and guidelines on creating ontologies, there exist significant variations in how Materials Science ontologies are currently developed. We seek to provide guidance in the form of a unified automated framework for developing interoperable and modular ontologies for Materials Data Science that simplifies the ontology terms matching by establishing a semantic bridge up to the Basic Formal Ontology(BFO). This framework provides key recommendations on how ontologies should be positioned within the semantic web, what knowledge representation …
A Simple One‐Item Nursing Falls Assessment Predicts Outcomes For Patients With Stage D Heart Failure Undergoing Surgical Advanced Therapies, Thomas Joseph O'Neill Iv, Eiran Z. Gorodeski
A Simple One‐Item Nursing Falls Assessment Predicts Outcomes For Patients With Stage D Heart Failure Undergoing Surgical Advanced Therapies, Thomas Joseph O'Neill Iv, Eiran Z. Gorodeski
Faculty Scholarship
Introduction: Frailty portends worse outcomes for patients with advanced heart failure (HF) undergoing surgical advanced therapies. Falls are characteristic of frailty, but it is unknown if the history of falls predicts post-operative risk. We hypothesized that a one-item fall screening is associated with worse outcomes. Methods: We conducted a retrospective study of all patients undergoing orthotopic heart transplantation (OHT) or left ventricular assist device (LVAD) implantation at our institution between 2020 and 2023. Our primary exposure of interest was falls, as assessed by a nursing questionnaire within 12 months or less prior to surgery. We tracked hospital- and ICU-length of …