Digital Commons Network^™

3d Fusion Between Fluoroscopy Angiograms And Spect Myocardial Perfusion Images To Guide Percutaneous Coronary Intervention, Haipeng Tang, Robert R. Bober, Chen Zhao, Chaoyang Zhang, Huiqing Zhu, Zhuo He, Zhihui Xu, Weihua Zhou

Faculty Publications

Background

Percutaneous coronary intervention (PCI) in stable coronary artery disease (CAD) is commonly triggered by abnormal myocardial perfusion imaging (MPI). However, due to the possibilities of multivessel disease, serial stenoses and variability of coronary artery perfusion distribution, an opportunity exists to better align anatomic stenosis with perfusion abnormalities to improve revascularization decisions. This study aims to develop a multi-modality fusion approach to assist decision-making for PCI.

Methods and Results

Coronary arteries from fluoroscopic angiography (FA) were reconstructed into 3D artery anatomy. Left ventricular (LV) epicardial surface was extracted from SPECT. The artery anatomy and epicardial surface were non-rigidly fused. The …

The Synthesis And Future Directions Of Empirical Research On International Students In The United States: The Insights From One Decade, Masha Krsmanovic

Faculty Publications

The purpose of this systematic review was to identify the trends in empirical research on international students in the United States produced between 2010 and 2019. After reviewing and synthesizing the characteristics of 334 research articles published over the past decade, I identify the areas that have been overly researched and the domains that have not yet been adequately explored. The overall findings of this review indicate that recent scholarly efforts have not always been aligned with the international student representation on U.S. campuses. Consequently, I provide eight critical recommendations for future research in the field in the context of …

Utilizing Theories And Evaluation In Digital Gaming Interventions To Increase Human Papillomavirus Vaccination Among Young Males: Qualitative Study, Gabrielle Darville, Jade Burns, Tanaka Chavanduka, Charkarra Anderson-Lewis

Faculty Publications

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. HPV attributes to most cancers including anal, oral, cervical, and penile. Despite infection rates in the United States, recommendations and communication campaigns have traditionally focused on females. Because of this, males lack knowledge about reasons for vaccination, the benefits of being vaccinated, and their HPV risk, overall. Gaming as a health education strategy can be beneficial as mechanism that can promote behavior change for this key demographic because of the popularity of gaming.

Objective: We sought to explore the relationship between gamification and …

The Rise And Fall Of The Ancient Northern Pike Master Sex Determining Gene, Qiaowei Pan, Romain Feron, Elodie Jouanno, Hugo Darras, Amaury Herpin, Ben Koop, Eric Rondeau, Frederick W. Goetz, Wesley A. Larson, Louis Bernatchez, Mike Tringali, Stephen S. Curran, Eric Saillant, Gael P.J. Denys, Frank A. Von Hippel, Songlin Chen, J. Andrés López, Hugo Verreycken, Konrad Ocalewicz, Rene Guyomard, Camille Eche, Jerome Lluch, Celine Roques, Hongxia Hu, Roger Tabor, Patrick Dehaan, Krista M. Nichols, Laurent Journot, Hugues Parrinello, Christophe Klopp, Elena A. Interesova, Vladimir Trifonov, Manfred Schartl, John Postlethwait, Yann Guiguen

Faculty Publications

The understanding of the evolution of variable sex determination mechanisms across taxa requires comparative studies among closely related species. Following the fate of a known master sex-determining gene, we traced the evolution of sex determination in an entire teleost order (Esociformes). We discovered that the northern pike (Esox lucius) master sex-determining gene originated from a 65 to 90 million-year-old gene duplication event and that it remained sex-linked on undifferentiated sex chromosomes for at least 56 million years in multiple species. We identified several independent species-or population-specific sex determination transitions, including a recent loss of a Y-chromosome. These findings highlight the …

Thermal-Induced Unfolding-Refolding Of A Nucleocapsid Covn Protein, Warin Rangubpit, Pornthep Sompornpisut, R. B. Pandey

Faculty Publications

Unfolding of a coarse-grained COVN protein from its native configuration shows a linear response with increasing temperature followed by non-monotonic double peaks in its radius of gyration. The protein conforms to a random coil of folded segments in native state with increasingly tenuous and globular structures in specific temperature regimes where the effective dimensions of corresponding structures D ≈ 1.6–2.4. Thermal agitation alone is not sufficient to fully eradicate its segmental folding as few local folds are found to persist around such residues as ⁶⁵L, ¹¹⁰Y, ²²⁴L, ³⁷⁴P even at high temperatures.

On The Origin And Structure Of The First Sharp Diffraction Peak Of Amorphous Silicon, Devilal Dahal, Hiroka Warren, Parthapratim Biswas

Faculty Publications

The structure of the first sharp diffraction peak (FSDP) of amorphous silicon (a-Si) near 2 Å⁻¹ is addressed with particular emphasis on the position, intensity, and width of the diffraction curve. By studying a number of continuous random network (CRN) models of a-Si, it is shown that the position and intensity of the FSDP are primarily determined by radial atomic correlations in the amorphous network on the length scale of 15 Å. A shell-by-shell analysis of the contribution from different radial shells reveals that key contributions to the FSDP originate from the second and fourth radial shells in the …

Policy Interactions In Large-Scale Marine Protected Areas, Rebecca L. Gruby, Noella J. Gray, Luke Fairbanks, Elizabeth Havice, Lisa M. Campbell, Alan Friedlander, Kirsten L.L. Oleson, King Sam, Lillian Mitchell, Quentin Hanich

Faculty Publications

Large-scale marine protected areas (LSMPAs) have proliferated in recent years, now accounting for most of the world's MPA coverage. However, little is known about LSMPA outcomes and the factors that affect them. Here we argue that policy interactions—the cumulative effect of co-existing policies for an issue and/or geographical area—can play a critical, but under-recognized, role in influencing LSMPA design and outcomes. We analyze interactions between national LSMPAs within Palau and Kiribati, and regional fisheries management established by the Nauru Agreement to show how policy actors can account for policy interactions in LSMPA design, and to demonstrate the profound influence that …

Characterisation Of Nano-Assemblies Inside Mesopores Using Neutron Scattering*, Yingzhen Ma, William T. Heller, Lilin He, William A. Shelton, Gernot Rother, Bhuvnesh Bharti

Faculty Publications

Adsorption of molecular and nanoscale matter in mesoporous materials is important in filtration and chromatography as well as membrane processes. However, the morphology and distribution of self-assembled structures of adsorbate formed within nanoconfined environments is largely unknown. Small Angle Neutron Scattering (SANS) with porous matrix matching the neutron scattering length density of the solvent has the potential to provide detailed information on the self-assemblies formed in pore spaces. However, analysis of such SANS profiles remains a challenge. In this study, we extend the SANS analysis method previously developed by Findenegg and co-workers to include interparticle correlations, providing a qualitative characterisation …

On The Enhanced Sulfur And Coking Tolerance Of Ni-Co-Rare Earth Oxide Catalysts For The Dry Reforming Of Methane, Changyi Jiang, Emily Loisel, David A. Cullen, James A. Dorman, Kerry M. Dooley

Faculty Publications

Sulfur and coking tolerance of Ni-based dry reforming catalysts were examined. Catalysts utilizing both Ce/Zr and Ce/La oxide supports, some with additional Co, were tested. Long-term reaction runs were conducted with and without sulfur in the feed. Catalysts were also characterized by STEM, XPS, XAFS and XANES and CO chemisorption. Only catalysts where Co was also present, and supported on the Ce-Zr oxide, were capable of extended sulfur tolerance at >20 ppm sulfur. This tolerance, along with a greatly reduced coking rate, is linked to Co in intimate contact with Ni, the mixture existing as clusters anchored and influenced electronically …

Effects Of Dilution And Pressure On Combustion Characteristics Within Externally Heated Micro-Tubes, Seyed Navid Roohani Isfahani, Vinicius M. Sauer, Ingmar Schoegl

Faculty Publications

This study investigates the impact of pressure and dilution on combustion behavior of C2H6/air/N2 mixtures within an externally heated micro-tube using both experimental and analytical techniques. Experiments are conducted for pressures up to 10 bar at multiple dilution levels and document three flame regimes, i.e. weak flames, FREI and normal flames. Characteristic temperatures for flame stabilization, as well as ignition and extinction are obtained by applying a novel thin filament pyrometry method (TFP), which uses a thin silicon carbide (SiC) filament that enables temperature measurements for both reacting and non-reacting cases. Results show a decrease of characteristic temperatures with increasing …

Marine Vehicles Localization Using Grid Cells For Path Integration, Ignacio Carlucho, Manuel F. Bailey, Mariano De Paula, Corina Barbalata

Faculty Publications

Autonomous Underwater Vehicles (AUVs) are platforms used for research and exploration of marine environments. However, these types of vehicles face many challenges that hinder their widespread use in the industry. One of the main limitations is obtaining accurate position estimation, due to the lack of GPS signal underwater. This estimation is usually done with Kalman filters. However, new developments in the neuroscience field have shed light on the mechanisms by which mammals are able to obtain a reliable estimation of their current position based on external and internal motion cues. A new type of neuron, called Grid cells, has been …

From Market-Ready Rovs To Low-Cost Auvs, Jonatan Scharff Willners, Ignacio Carlucho, Sean Katagiri, Chandler Lemoine, Joshua Roe, Dylan Stephens, Tomasz Luczynski, Shida Xu, Yaniel Carreno, Eric Pairet, Corina Barbalata, Yvan Petillot, Sen Wang

Faculty Publications

Autonomous Underwater Vehicles (AUVs) are becoming increasingly important for different types of industrial applications. The generally high cost of AUVs restricts the access to them and therefore advances in research and technological development. However, recent advances have led to lower cost commercially available Remotely Operated Vehicles (ROVs), which present a platform that can be enhanced to enable a high degree of autonomy, similar to that of a high-end AUV. In this article, we present how a low-cost commercial-off-the-shelf ROV can be used as a foundation for developing versatile and affordable AUVs. We introduce the required hardware modifications to obtain a …

Event-Triggered Control For Systems With State Delays Using A Positive Systems Approach, Frederic Mazenc, Michael Malisoff, Corina Barbalata, Zhong Ping Jiang

Faculty Publications

We provide a new positive system approach to event-triggered feedback control of linear systems with state delays. We use an interval observer method and linear Lyapunov functions to prove global exponential stability of the closed loop systems. Our two examples illustrate the usefulness of our method for counteracting the effects of potentially destabilizing state delays.

Μralp And Beyond: Micro-Technologies And Systems For Robot-Assisted Endoscopic Laser Microsurgery, Leonardo S. Mattos, Alperen Acemoglu, André Geraldes, Andrea Laborai, Andreas Schoob, Brahim Tamadazte, Brian Davies, Bruno Wacogne, Christian Pieralli, Corina Barbalata, Darwin G. Caldwell, Dennis Kundrat, Diego Pardo, Edward Grant, Francesco Mora, Giacinto Barresi, Giorgio Peretti, Jesùs Ortiz, Kanty Rabenorosoa, Laurent Tavernier, Lionel Pazart, Loris Fichera, Luca Guastini, Lüder A. Kahrs, Micky Rakotondrabe, Nicolas Andreff, Nikhil Deshpande, Olivier Gaiffe, Rupert Renevier, Sara Moccia, Sergio Lescano, Tobias Ortmaier, Veronica Penza

Faculty Publications

Laser microsurgery is the current gold standard surgical technique for the treatment of selected diseases in delicate organs such as the larynx. However, the operations require large surgical expertise and dexterity, and face significant limitations imposed by available technology, such as the requirement for direct line of sight to the surgical field, restricted access, and direct manual control of the surgical instruments. To change this status quo, the European project μRALP pioneered research towards a complete redesign of current laser microsurgery systems, focusing on the development of robotic micro-technologies to enable endoscopic operations. This has fostered awareness and interest in …

Deep Learning-Based Hardness Prediction Of Novel Refractory High-Entropy Alloys With Experimental Validation, Uttam Bhandari, Congyan Zhang, Congyuan Zeng, Shengmin Guo, Aashish Adhikari, Shizhong Yang

Faculty Publications

Hardness is an essential property in the design of refractory high entropy alloys (RHEAs). This study shows how a neural network (NN) model can be used to predict the hardness of a RHEA, for the first time. We predicted the hardness of several alloys, including the novel C0.1Cr3Mo11.9Nb20 Re15Ta30W20 using the NN model. The hardness predicted from the NN model was consistent with the available experimental results. The NN model prediction of C0.1Cr3Mo11.9Nb20Re15Ta30W20 was verified by experimentally synthesizing and investigating its microstructure properties and hardness. This model provides an alternative route to determine the Vickers hardness of RHEAs.

Evaluating Grease Degradation Through Contact Angle Approach, Michael M. Khonsari, K. P. Lijesh, Roger A. Miller, Raj Shah

Faculty Publications

Grease is highly susceptible to degradation due to regular usage and the severity of the operating conditions. Degradation can negatively impact the performance of grease-lubricated machinery, demanding frequent maintenance to avoid premature failure of machine elements. Quantification of grease degradation has proven to be a formidable task, for which no accepted standards are currently available. In this paper, we extend the results of a novel approach developed recently for the evaluation of the water-resistant property in grease to quantify degradation. The methodology is based on measurements of the contact angle of a water droplet on the surface of a sample …

Tensor Multivariate Trace Inequalities And Their Applications, Shih Yu Chang, Hsiao Chun Wu

Faculty Publications

In linear algebra, the trace of a square matrix is defined as the sum of elements on the main diagonal. The trace of a matrix is the sum of its eigenvalues (counted with multiplicities), and it is invariant under the change of basis. This charac-terization can be used to define the trace of a tensor in general. Trace inequalities are mathematical relations between different multivariate trace functionals involving linear operators. These relations are straightforward equalities if the involved linear operators commute, however, they can be difficult to prove when the non-commuting linear operators are involved. Given two Hermitian tensors H1 …

Intelligent Spectrum Management And Trajectory Design For Uav-Assisted Cognitive Ambient Backscatter Networks, Jiazhou Liu, Sa Xiao, Huayan Guo, Xiangwei Zhou, Shixin He

Faculty Publications

In this paper, we consider a novel Internet of Things (IoT) system in smart city called unmanned aerial vehicle- (UAV-) assisted cognitive backscatter network, where a UAV is employed as both a relay and a radio frequency source to help the data transmission between ground IoT backscatter devices (BDs) and a remote data center (DC). However, since the IoT applications are usually not assigned dedicated spectrum resource in smart cities, these data transmissions from BDs to the DC should share the licensed spectrum of cellular users (CUs). Therefore, we aim to maximize the minimum uplink throughput among all BDs while …

Octo-Tiger's New Hydro Module And Performance Using Hpx+Cuda On Ornl's Summit, Patrick Diehl, Gregor Daiß, Dominic Marcello, Kevin Huck, Sagiv Shiber, Hartmut Kaiser, Juhan Frank, Geoffrey C. Clayton, Dirk Pfluger

Faculty Publications

Octo-Tiger is a code for modeling three-dimensional self-gravitating astrophysical fluids. It was particularly designed for the study of dynamical mass transfer between interacting binary stars. Octo-Tiger is parallelized for distributed systems using the asynchronous many-task runtime system, the C++ standard library for parallelism and concurrency (HPX) and utilizes CUDA for its gravity solver. Recently, we have remodeled OctoTiger's hydro solver to use a three-dimensional reconstruction scheme. In addition, we have ported the hydro solver to GPU using CUDA kernels. We present scaling results for the new hydro kernels on ORNL's Summit machine using a Sedov-Taylor blast wave problem. We also …

In The Beginning: Foundations Of A Successful Deanship, Neil Fulton

Faculty Publications

No abstract provided.

Aristocratic Excellence, Secular Ecumenism, And The Life Of The Modern Law School: Book Review, Neil Fulton

Faculty Publications

Anthony Kronman and John Sexton have both authored books about the state of higher education: Kronman's entitled, The Assault on American Excellence; Sexton's entitled, Standing for Reason. Both authors have extensive experience as instructors and administrators. Both have academic careers centered around law schools. Both use their books to explore the critical mission of universities in modern society, political and social challenges to that mission, and how to overcome those challenges. Both books are informed, provocative, and ultimately hopeful about the future of higher education. Both, while centered on universities more generally, provide avenues to think about the …

The Trial Of John Scopes, Jonathan Van Patten

Faculty Publications

The trial of John Scopes is an important landmark in legal history. What happened in Dayton, Tennessee, in 1925, may have been overtaken, however, by the lore springing up in its aftermath. This article places the trial in context and re-examines the proceedings, and the lawyers, in order to understand what the trial means for us today.

Tribute To John Hagemann (In The Trial Of John Scopes), Jonathan Van Patten

Faculty Publications

No abstract provided.

Anti-Consumption In The Context Of Brand Relationships, Marc Fetscherin, Raghabendra Kc

Faculty Publications

This paper presents a conceptual model that outlines the various brand relationships consumers have with a special focus on negative brand relationships that relates to anti-brand behaviors.

Based on the empathy map, the model consists of four main parts: how consumers think (share of mind) and feel (share of heart) about brands, which in turn effects what consumers say (share of voice) and do (share of wallet) with them.

The model combines more than 40 branding concepts into one comprehensive, coherent, unified and easy-to-understand model where concepts are categorized by their degree of intensity.

Mass Spectrometric Calibration Procedure For Real-Time Detection Of Lighter Hydrocarbons, M F. Mbaegbu, P L. Adhikari, I Gupta, M Rowe

Faculty Publications

Determining gas compositions from live well fluids on a drilling rig is critical for real time formation evaluation. Development and utilization of a reliable mass spectrometric method to accurately characterize these live well fluids are always challenging due to lack of a robust and effectively selective instrument and procedure. The methods currently utilized need better calibration for the characterization of light hydrocarbons (C-1-C-6) at lower concentrations. The primary goal of this research is to develop and optimize a powerful and reliable analytical method to characterize live well fluid using a quadruple mass spectrometer (MS). The mass spectrometers currently being used …

Viscosity Robust Weak Galerkin Finite Element Methods For Stokes Problems, B Wang, L Mu

Faculty Publications

In this paper, we develop a viscosity robust weak Galerkin finite element scheme for Stokes equations. The major idea for achieving pressure-independent energy-error estimate is to use a divergence preserving velocity reconstruction operator in the discretization of the right hand side body force. The optimal convergence results for velocity and pressure have been established in this paper. Finally, numerical examples are presented for validating the theoretical conclusions.

An Open-Source Code For Fluid Flow Simulations In Unconventional Fractured Reservoirs, B Wang, C Fidelibus

Faculty Publications

In this article, an open-source code for the simulation of fluid flow, including adsorption, transport, and indirect hydromechanical coupling in unconventional fractured reservoirs is described. The code leverages cutting-edge numerical modeling capabilities like automatic differentiation, stochastic fracture modeling, multicontinuum modeling, and discrete fracture models. In the fluid mass balance equation, specific physical mechanisms, unique to organic-rich source rocks, are included, like an adsorption isotherm, a dynamic permeability-correction function, and an Embedded Discrete Fracture Model (EDFM) with fracture-to-well connectivity. The code is validated against an industrial simulator and applied for a study of the performance of the Barnett shale reservoir, where …

Testing Encoding Specificity And The Diagnostic Feature-Detection Theory Of Eyewitness Identification, With Implications For Showups, Lineups, And Partially Disguised Perpetrators, Curt Carlson, Jacob A. Hemby, Alex R. Wooten, Alyssa R. Jones

Faculty Publications

The diagnostic feature-detection theory (DFT) of eyewitness identification is based on facial information that is diagnostic versus non-diagnostic of suspect guilt. It primarily has been tested by discounting non-diagnostic information at retrieval, typically by surrounding a single suspect showup with good fillers to create a lineup. We tested additional DFT predictions by manipulating the presence of facial information (i.e., the exterior region of the face) at both encoding and retrieval with a large between-subjects factorial design (N = 19,414). In support of DFT and in replication of the literature, lineups yielded higher discriminability than showups. In support of encoding specificity, …

Dicer Represses The Interferon Response And The Double-Stranded Rna-Activated Protein Kinase Pathway In Mouse Embryonic Stem Cells, Chandan Gurung, Mona Fendereski, Krishna Sapkota, Jason Guo, Faqing Huang, Yan Lin Guo

Faculty Publications

Recent studies have demonstrated that embryonic stem cells (ESCs) are deficient in expressing type I interferons (IFN), the cytokines that play key roles in antiviral responses. However, the underlying molecular mechanisms and biological implications of this finding are poorly understood. In this study, we developed a synthetic RNA-based assay that can simultaneously assess multiple forms of antiviral responses. Dicer is an enzyme essential for RNA interference (RNAi), which is used as a major antiviral mechanism in invertebrates. RNAi activity is detected in wild-type ESCs but is abolished in Dicer knockout ESCs (D-/-ESCs) as expected. Surprisingly, D-/-ESCs have gained the ability …

Direct Determination Of Absolute Stereochemistry Of Α-Methylselenocysteine Using The Mosher Method, Robert J. Wehrle, Douglas R. Powell, Douglas S. Masterson

Faculty Publications

Mosher amides of α-methylselenocysteine were synthesized to determine the absolute stereochemistry of the sterically hindered α-carbon utilizing ¹H, ¹³C, ¹⁹F, and ⁷⁷Se NMR spectroscopies. After analysis of these spectra using the established Mosher method, the stereochemistry of the α-carbon was determined to be (R), which was subsequently confirmed using x-ray crystallography.