Digital Commons Network^™

Proteomic Profiling Platforms Head To Head: Leveraging Genetics And Clinical Traits To Compare Aptamer- And Antibody-Based Methods, Daniel H. Katz, Jeremy M. Robbins, Shuliang Deng, Usman A. Tahir, Alexander G. Bick, Akhil Pampana, Zhi Yu, Debby Ngo, Mark D. Benson, Zsu-Zsu Chen, Daniel E. Cruz, Dongxiao Shen, Yan Gao, Claude Bouchard, Mark A. Sarzynski Facsm, Adolfo Correa, Pradeep Natarajan, James G. Wilson, Robert E. Gerszten

Faculty Publications

High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is used increasingly in human studies. However, direct analyses to address the relative strengths and weaknesses of these platforms are lacking. We assessed findings from the SomaScan1.3K (N = 1301 reagents), the SomaScan5K platform (N = 4979 reagents), and the Olink Explore (N = 1472 reagents) profiling techniques in 568 adults from the Jackson Heart Study and 219 participants in the HERITAGE Family Study across four performance domains: precision, accuracy, analytic breadth, and phenotypic associations leveraging detailed clinical phenotyping and genetic data. Across these studies, we show evidence …

The Use Of Digital Health Tools For Health Promotion Among Women With And Without Chronic Diseases: Insights From The 2017-2020 Health Information National Trends Survey, Kobi V. Ajayi, Elizabeth Wachira, Henry K. Onyeaka, Tyra Montour

Faculty Publications

Background: In the United States, almost 90% of women are at risk of at least one chronic condition. However, the awareness, management, and monitoring of these conditions are low and present a substantial public health problem. Digital health tools can be leveraged to reduce the alarmingly high rates of chronic condition–related mortality and morbidity in women. Objective: This study aimed to investigate the 4-year trend of digital health use for health promotion among women with chronic conditions in the United States. Methods: Data for this study were obtained from the 2017 to 2020 iterations of the Health Information Trends Survey …

Artificial Neural Networks And Gradient Boosted Machines Used For Regression To Evaluate Gasification Processes: A Review, Owen Sedej, Eric Mbonimpa, Trevor Sleight, Jeremy M. Slagley

Faculty Publications

Waste-to-Energy technologies have the potential to dramatically improve both the natural and human environment. One type of waste-to-energy technology that has been successful is gasification. There are numerous types of gasification processes and in order to drive understanding and the optimization of these systems, traditional approaches like computational fluid dynamics software have been utilized to model these systems. The modern advent of machine learning models has allowed for accurate and computationally efficient predictions for gasification systems that are informed by numerous experimental and numerical solutions. Two types of machine learning models that have been widely used to solve for quantitative …

Understanding Across The Senses: Cross-Modal Studies Of Cognition In Cetaceans, Jason N. Bruck, Adam A. Pack

Faculty Publications

Cross-modal approaches to the study of sensory perception, social recognition, cognition, and mental representation have proved fruitful in humans as well as in a variety of other species including toothed whales in revealing equivalencies that suggest that different sensory stimuli associated with objects or individuals may effectively evoke mental representations that are, respectively, object based or individual based. Building on established findings of structural equivalence in the form of spontaneous recognition of complex shapes across the modalities of echolocation and vision and behavior favoring identity echoic–visual cross-modal relationships over associative echoic–visual cross-modal relationships, examinations of transitive inference equivalencies from initially …

Effects Of Caffeine, Methylliberine, And Theacrine On Vigilance, Marksmanship, And Hemodynamic Responses In Tactical Personnel: A Double-Blind, Randomized, Placebo-Controlled Trial, Harry P. Cintineo, Marissa L. Bello, Alexa J. Chandler, Thomas D. Cardaci, Bridget A. Mcfadden, Shawn M. Arent

Faculty Publications

Background

Tactical athletes require fast reaction times (RT) along with high levels of vigilance and marksmanship performance. Caffeine has been shown to improve these measures but also results in increased blood pressure and jitteriness. Research on other purine alkaloids, such as methylliberine and theacrine, has suggested they do not increase blood pressure or jitteriness to the same extent, but their impact on tactical performance is unknown.

Methods

A between-subjects, randomized, placebo-controlled design was used to test the effects of placebo (PLA), 300 mg caffeine (CAF), and a combination of 150 mg caffeine, 100 mg methylliberine, and 50 mg theacrine (CMT) …

Accountability: Construct Definition And Measurement Of A Virtue Vital To Flourishing, Charlotte Vanoyen-Witvliet, Sung Joon Jang, Byron R. Johnson, C. Stephen Evans, Jack W. Berry, Joseph Leman, Robert C. Roberts, John Peteet, Andrew B. Torrance, Ashley N. Hayden

Faculty Publications

Embracing accountability to others for one’s responsibilities within relationships is important for flourishing, yet underexamined. An interdisciplinary team defined the construct of accountability and developed an 11-item single-factor Accountability Scale. In national samples with US census demographic representation (total N = 1257), we conducted psychometric analyses using methods from classical test theory (exploratory and confirmatory factor analyses) and item response theory. The Accountability Scale demonstrated internal consistency, construct validity, test-retest reliability, and incremental validity. Accountability correlated positively with relational variables (agreeableness, empathy) responsibility-oriented variables (conscientiousness, self-regulation), virtues (gratitude, forgiveness, limitations-owning humility), relational repair, perceived meaning presence, and flourishing, inversely with …

All Is Perception, Robert Friedman

Faculty Publications

This editorial addresses the universality and importance of the science of perception. In particular, recently published studies in this journal illustrate the natural variations in perception. These articles are a reminder of perception as a natural process with inherent variations and that any two individuals are not guaranteed to form the same representation of an object, regardless of whether it originates from the senses or not. Since perception is a foundation for higher cognition, it also has an immense influence on studies of humanity and interpretations of natural processes.

Measurement Of The Branching Fractions Of The B+ → Η′ℓ+Νℓ And B+ → Η′ℓ+Νℓ Decays With Signal-Side Only Reconstruction In The Full Q2 Range, U. Gebauer, C. Beleño, A. Frey, I. Adachi, K. Adamczyk, H. Aihara, S. Al Said, D. M. Asner, H. Atmacan, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, P. Behera, K. Belous, J. Bennett, M. Bessner, V. Bhardwaj, B. Bhuyan, Milind Purohit, Et. Al.

Faculty Publications

The branching fractions of the decays B⁺ → ηl⁺νl and B⁺ → ηl⁺νl are measured, where l is either an electron or a muon, using a data sample of 711 fb⁻¹ containing 772 × 10⁶ BB̅ pairs collected at the ϒ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e⁺e⁻ collider. To reduce the dependence of the result on the form factor model, the measurement is performed over the entire q² range. The resulting branching fractions are B(B⁺ → η ℓ + ν ℓ)=(2.83 …

Measurement Of The Branching Fractions Of The B+ → Ηl+ Νl And B+ → Η0l+ Νl Decays With Signal-Side Only Reconstruction In The Full Q2 Range, U. Gebauer, C. Beleño, A. Frey, I. Adachi, K. Adamczyk, H. Aihara, S. Al Said, D. M. Asner, H. Atmacan, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, P. Behera, K. Belous, J. Bennett, M. Bessner, V. Bhardwaj, B. Bhuyan, Milind Purohit, Et. Al.

Faculty Publications

The branching fractions of the decays B⁺ → ηl+νl and B+ → η0 lþνl are measured, where l is either an electron or a muon, using a data sample of 711 fb⁻¹ containing 772 × 10⁶ BB̅ pairs collected at the ϒ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e⁺e⁻ collider. To reduce the dependence of the result on the form factor model, the measurement is performed over the entire q² range. The resulting branching fractions are B(B⁺ → ηlþνl)=(2.83 ± 0.55_(stat.) ± 0.34_(syst.) )× 10 …

The Impact Of Dieting Culture Is Different Between Sexes In Endurance Athletes: A Cross-Sectional Analysis, Austin J. Graybeal, Andreas Kreutzer, Jada L. Willis, Robyn Braun-Trocchio, Kamiah Moss, Meena Shah

Faculty Publications

Background: Frequent dieting is common in athletes attempting to achieve a body composition perceived to improve performance. Excessive dieting may indicate disordered eating (DE) behaviors and can result in clinical eating disorders. However, the current nutrition patterns that underly dieting culture are underexplored in endurance athletes. Therefore, the purpose of this study was to identify the sex differences in nutrition patterns among a group of endurance athletes.

Methods: Two-hundred and thirty-one endurance athletes (females = 124) completed a questionnaire regarding their dieting patterns and associated variables.

Results: The majority of athletes did not follow a planned diet …

From Start To Finish: Examining Factors Associated With Higher Likelihood Of Publication Among Abstracts Presented At An International Infectious Diseases Scientific Meeting, Asia J. Johnson, Christopher M. Bland, Chengwen Teng, Lily Zheng, J Colin Hungerpiller, Morgan Easterling, Sarah Arnold, Madeline Dean, Carrington Royals, P. Brandon Bookstaver

Faculty Publications

Background The landscape of infectious diseases research by interprofessional teams continues to change in both scope and engagement. Limited information exists regarding publication metrics and factors associated with publication of abstracts presented at professional infectious diseases meetings.

Methods This was a retrospective, observational study evaluating abstracts presented at IDWeek in 2017 and 2018. The primary endpoint was the proportion of abstracts that were subsequently published in peer-reviewed journals. Factors associated with publication were evaluated, and a description of publication metrics was reported.

Results Of the 887 abstracts analyzed from the IDWeek meetings, 236 (26.6%) were published. Significantly more abstracts were …

Electron Energization Signatures In Traveling Kinetic Alfvén Waves At Storm Time Injection Fronts, A. J. Hull, P. A. Damiano, C. C. Chaston, J. R. Johnson, G. D. Reeves

Faculty Publications

The properties of traveling kinetic Alfvén waves (KAWs) and their role in energizing electrons in the inner magnetosphere during a geomagnetic storm are examined using measurements from the Van Allen Probes and Gyrofluid-Kinetic Electron (GKE) model simulations. Traveling KAWs occur in the vicinity of energetic plasma injection fronts in association with magnetic field dipolarizations. The KAWs coincide with energized field-aligned electrons at energies ≲1 keV. By using observational constraints and incorporating hot and cold electron populations, the GKE simulations are able to reproduce the observed energized electron distribution signatures. The modeling results demonstrate the crucial importance of cold electrons for …

Perspectives Of African American Women About Barriers To Breast Cancer Prevention And Screening Practices: A Qualitative Study, Abosede F. Obikunle, Bosede Ade-Oshifogun

Faculty Publications

Breast cancer is a severe illness that often has fatal consequences. Adherence to the recommendations for breast cancer surveillance is poorly practiced among African American women. The study aimed to identify barriers to preventative screening for breast cancer among African American women (AAW) using a qualitative research design. We explored the influence of personal barriers, stereotypes, socioeconomic status, culture, attitudes, and beliefs on African American women's behavior regarding breast cancer screening. Fourteen African American women were interviewed. Data analysis was completed with Interpretative Phenomenology Approach (IPA). This study's findings demonstrated that African American women perceived the barriers to breast cancer …

Parental Genetic Contributions To Neonatal Temperament In A Nonhuman Primate (Macaca Mulatta) Model, Elizabeth K. Wood, Jacob N. Hunter, Joseph A. Olsen, Laura Almasay, Stephen G. Lindell, David Goldman, Christina S. Barr, Stephen J. Suomi, Daniel B. Kay, James Dee Higley

Faculty Publications

Temperament is an individual’s nature and is widely believed to have a heritable foundation. Few studies, however, have evaluated paternal and maternal contributions to the triadic dimensions of temperament. Rhesus monkeys are widely utilized to model genetic contributions to human development due to their close genetic-relatedness and common temperament structure, providing a powerful translational model for investigating paternal and maternal genetic influences on temperament. The temperament of rhesus monkey infants born to 19 different sires and 50 different dams was assessed during the first month of life by comparing the temperament of paternal or maternal half-siblings reared with their mothers …

Hexavalent Chromium Increases The Metabolism And Genotoxicity Of Aromatic Amine Carcinogens 4-Aminobiphenyl And Β-Naphthylamine In Immortalized Human Lung Epithelial Cells, James T.F. Wise, Raúl A. Salazar-González, Kennedy M. Walls, Mark A. Doll, Mariam R. Habil, David W. Hein

Faculty Publications

Humans are exposed to carcinogenic chemicals via occupational and environmental exposures. Common chemicals of concern that can occur in exposures together are aromatic amines (e.g., 4-aminobiphenyl [4-ABP] and β-naphthylamine [BNA]) and hexavalent chromium (Cr[VI]). Arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) are key to the metabolism of aromatic amines and their genotoxicity. The effects of Cr(VI) on the metabolism of aromatic amines remains unknown as well as how it may affect their ensuing toxicity. The objective of the research presented here is to investigate the effects of Cr(VI) on the metabolism and genotoxicity of 4-ABP and BNA in immortalized …

Integrated Modeling Of Dynamic Marsh Feedbacks And Evolution Under Sea-Level Rise In A Mesotidal Estuary (Plum Island, Ma, Usa), Karim Alizad, James T. Morris, Matthew V. Bilskie, Davina L. Passeri, Scott C. Hagen

Faculty Publications

Around the world, wetland vulnerability to sea-level rise (SLR) depends on different factors including tidal regimes, topography, creeks and estuary geometry, sediment availability, vegetation type, etc. The Plum Island estuary (PIE) is a mesotidal wetland system on the east coast of the United States. This research applied a newly updated Hydro-MEM (integrated hydrodynamic-marsh) model to assess the impacts of intermediate-low (50 cm), intermediate (1 m), and intermediate-high (1.5 m) SLR on marsh evolution by the year 2100. Model advancements include capturing vegetation change, inorganic and below and aboveground organic matter portion of marsh platform accretion, and mudflat creation. Although the …

A Structural Equation Modeling Analysis To Explore Diabetes Self-Care Factors In A Rural Sample, Laurie Abbott, Lucinda Graven, Glenna Schluck, Jennifer Lemacks

Faculty Publications

Diabetes is a public health problem that requires management to avoid health sequelae. Little is known about the determinants that influence diabetes self-care activities among rural populations. The purpose of this analysis was to explore the relationships among diabetes self-care activities, diabetes knowledge, perceived diabetes self-management, diabetes fatalism, and social support among an underserved rural group in the southern United States. A diabetes health promotion program was tested during a cluster randomized trial that tested a disease risk reduction program among adults living with prediabetes and diabetes. A structural equation model was fit to test psychosocial factors that influence diabetes …

Ethnic/Racial Differences In Alcohol Use: Does Drinking Refusal Self-Efficacy Matter?, P. Priscilla Lui, Savannah M. Krantz, Michael B. Madson

Faculty Publications

Introduction: College students—including those of Hispanic backgrounds—are at risk for hazardous drinking. Research has shown robust group differences between Hispanic and White individuals in alcohol use outcomes. The ability to resist alcohol consumption can be leveraged to reduce hazardous drinking; however, little research has examined Hispanic-White differences and whether drinking refusal self-efficacy accounts for group differences in hazardous drinking. Considering Hispanic individuals make up the largest ethnic/racial minority group in the United States, it is important to identify malleable psychological factors that prevent and reduce drinking problems. Method: Hispanic and White college students at two predominantly White institutions …

Strain And Strain Rate In Friction Extrusion, Xiao Li, Md Reza-E- Rabby, Anthony Guzman, Glenn Grant, Suveen Mathaudhu, Michah Hinton, Anthony P. Reynolds

Faculty Publications

Friction extrusion is a metal forming process that generates large plastic strains and deformation-induced heating through friction between a rotating die and the material to be extruded. The final deformation state in friction extruded wire has been visualized in previous studies but the distribution and evolution of strain and strain rate inside the solid material have yet to be elucidated. This paper develops an approach that reveals the deformation during the process by visualizing the shape change of the pre-embedded markers in the remnant billet. For the first time, the distribution of steady-state strain and strain rate in friction extrusion …

Analysis Of The Temperature Characteristics Of High-Speed Train Bearings Based On A Dynamics Model And Thermal Network Method, Baosen Wang, Yongqiang Liu, Bin Zhang, Wenqing Huai

Faculty Publications

High-speed trains often use temperature sensors to monitor the motion state of bearings. However, the temperature of bearings can be affected by factors such as weather and faults. Therefore, it is necessary to analyze in detail the relationship between the bearing temperature and influencing factors. In this study, a dynamics model of the axle box bearing of high-speed trains is established. The model can obtain the contact force between the rollers and raceway and its change law when the bearing contains outer-ring, inner-ring, and rolling-element faults. Based on the model, a thermal network method is introduced to study the temperature …

The Power Of Humility, Andrea Luxton

Faculty Publications

No abstract provided.

Andrews University 2022-2025 Strategic Plan - Storyline One: Access, Andrea Luxton

Faculty Publications

No abstract provided.

Improved Building-Specific Flood Risk Assessment And Implications Of Depth-Damage Function Selection, Ehab Gnan, Carol J. Friedland, Md Adilur Rahim, Rubayet Bin Mostafiz, Robert V. Rohli, Fatemeh Orooji, Arash Taghinezhad, Jasmin Mcelwee

Faculty Publications

Average annual loss (AAL) is traditionally used as the basis of assessing flood risk and evaluating risk mitigation measures. This research presents an improved implementation to estimate building-specific AAL, with the flood hazard of a building represented by the Gumbel extreme value distribution. AAL is then calculated by integrating the area under the overall loss-exceedance probability curve using trapezoidal Riemann sums. This implementation is compared with existing AAL estimations from flood risk assessment. A sensitivity analysis is conducted to examine the variability in AAL results based on depth-damage function (DDF) choice. To demonstrate the methodology, a one-story single-family residence is …

Liquid-Phase Effects On Adsorption Processes In Heterogeneous Catalysis, Mehdi Zare, Mohammad S. Saleheen, Nirala Singh, Mark J. Uline, Muhammad Faheem, Andreas Heyden

Faculty Publications

Aqueous solvation free energies of adsorption have recently been measured for phenol adsorption on Pt(111). Endergonic solvent effects of ∼1 eV suggest solvents dramatically influence a metal catalyst's activity with significant implications for the catalyst design. However, measurements are indirect and involve adsorption isotherm models, which potentially reduces the reliability of the extracted energy values. Computational, implicit solvation models predict exergonic solvation effects for phenol adsorption, failing to agree with measurements even qualitatively. In this study, an explicit, hybrid quantum mechanical/molecular mechanical approach for computing solvation free energies of adsorption is developed, solvation free energies of phenol adsorption are computed, …

Covid-19 In The United States As Affective Frame, John Protevi

Faculty Publications

In this paper I attempt to contribute to the developing field of “political philosophy of mind.” To render concrete the notion of “affective frame,” a social situation which pre-selects for salience and valence of environmental factors relative to a subject’s life, I conduct a case study of a deleterious socially instituted affective frame, which, during the early days of the COVID19 pandemic in the United States, produced individuated circumstances that came crashing down on “essential workers” who were forced into a double bind. We saw here an untenable and ultimately fatal situation that forced a choice between, on the one …

Adolescent-Reported Household Food Insecurity And Adolescents' Poor Mental And Physical Health And Food Insufficiency In Kenya, Amanda S. Mcrell, Maryah S. Fram, Edward A. Frongillo Jr.

Faculty Publications

Background

Objectives

Methods

Inhibition Of Cdk8/19 Mediator Kinase Potentiates Her2-Targeting Drugs And Bypasses Resistance To These Agents In Vitro And In Vivo, Xiaokai Ding, Amanda C. Sharko, Martina S.J. Mcdermott, Gary P. Schools, Alexander Chumanevich, Hao Ji, Jing Li, Li Zhang, Zachary T. Mack, Vitali Sikirzhytski, Michael Shtutman, Laura Ivers, Norma O'Donovan, John Crown, Balazs Gyorffy, Mengqian Chen, Igor Roninson, Eugenia Broude

Faculty Publications

Breast cancers (BrCas) that overexpress oncogenic tyrosine kinase receptor HER2 are treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase inhibitors (such as lapatinib). However, most patients with metastatic HER2⁺BrCa have intrinsic resistance and nearly all eventually become resistant to HER2-targeting therapy. Resistance to HER2-targeting drugs frequently involves transcriptional reprogramming associated with constitutive activation of different signaling pathways. We have investigated the role of CDK8/19 Mediator kinase, a regulator of transcriptional reprogramming, in the response of HER2⁺BrCa to HER2-targeting drugs. CDK8 was in the top 1% of all genes ranked by correlation with shorter relapse-free …

Insight In Thermomechanical Constitutive Modeling Of Shape Memory Polymers, Amir Shojaei, Wei Xu, Cheng Yan, Qianxi Yang, Guoqiang Li

Faculty Publications

Shape memory polymers (SMPs) are a new member of the smart materials family. SMPs have found wide applications or potential applications in almost all manmade structures and devices. In order to better design smart structures and devices using SMPs, thermomechanical constitutive modeling is essential. In this insight paper, we will focus on presenting several multi-length-scale and multi-physics modeling frameworks, including the thermodynamics consistent model, elasto-viscoplastic model, statistical mechanics model, and phase evaluation law model. The SMPs modeled will include amorphous one-way shape memory polymers, semicrystalline one-way shape memory polymers, semicrystalline two-way shape memory polymers, and functional and mechanical damage effects …

The Association Between Dietary Inflammatory Index, Dietary Antioxidant Index, And Mental Health In Adolescent Girls: An Analytical Study, Parvin Dehghan, Marzieh Nejati, Amir Almasi-Hashiani, Sevda Saleh-Ghadimi, Rezza Parsi, Hamed Jafari-Vayghan, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd

Faculty Publications

Background Diet is considered as one of the modifiable factors that appears to exert a vital role in psychological status. In this way, we designed this study to examine the association between dietary inflammatory index (DII), dietary antioxidant index (DAI), and mental health in female adolescents. Methods This cross-sectional study included 364 female adolescents selected from high schools in the five regions of Tabriz, Iran. A 3-day food record was used to extract the dietary data and calculate DII/DAI scores. DII and DAI were estimated to assess the odds of depression, anxiety, and stress based on the Depression Anxiety Stress …

Just Strict Liability, Cristina Carmody Tilley

Faculty Publications

Theorists who contend that tort is designed to do justice cannot explain strict liability. The strict sector plagues these scholars because it extracts payment from defendants who have acted reasonably and are therefore considered innocent. If tort is about wronging and recourse, then strict liability makes no sense. Stymied, justice theorists have ceded the sector to economically minded counterparts who are concerned primarily with efficient market outcomes. As this theory has taken hold, some have declared strict liability “dead.” This Article offers a justice theory of the interpersonal wrong that permits liability in the absence of traditional fault; namely, the …