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Identifying Cancers For Cdk8/19 Inhibitor Therapy, Igor Roninson, Balázs Győrffy, Zachary T. Mack, Alexander A. Shtil, Michael S. Shtutman, Mengqian Chen, Eugenia Broude Aug 2019

Identifying Cancers For Cdk8/19 Inhibitor Therapy, Igor Roninson, Balázs Győrffy, Zachary T. Mack, Alexander A. Shtil, Michael S. Shtutman, Mengqian Chen, Eugenia Broude

Faculty Publications

CDK8 and CDK19 Mediator kinases are transcriptional co-regulators implicated in several types of cancer. Small-molecule CDK8/19 inhibitors have recently entered or are entering clinical trials, starting with breast cancer and acute myeloid leukemia (AML). To identify other cancers where these novel drugs may provide benefit, we queried genomic and transcriptomic databases for potential impact of CDK8, CDK19, or their binding partner CCNC. sgRNA analysis of a panel of tumor cell lines showed that most tumor types represented in the panel, except for some central nervous system tumors, were not dependent on these genes. In contrast, analysis of clinical samples for …

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Dietary Inflammatory Index And Its Relationship With Cervical Carcinogenesis Risk In Korean Women: A Case-Control Study, Sundara Raj Sreeja, Hyun Yi Lee, Minji Kwon, Nitin Shivappa, James R. Hébert, Mi Kyung Kim Aug 2019

Dietary Inflammatory Index And Its Relationship With Cervical Carcinogenesis Risk In Korean Women: A Case-Control Study, Sundara Raj Sreeja, Hyun Yi Lee, Minji Kwon, Nitin Shivappa, James R. Hébert, Mi Kyung Kim

Faculty Publications

Several studies have reported that diet’s inflammatory potential is related to chronic diseases such as cancer, but its relationship with cervical cancer risk has not been studied yet. The aim of this study was to investigate the association between Dietary Inflammatory Index (DII®) and cervical cancer risk among Korean women. This study consisted of 764 cases with cervical intraepithelial neoplasia (CIN)1, 2, 3, or cervical cancer, and 729 controls from six gynecologic oncology clinics in South Korea. The DII was computed using a validated semiquantitative Food Frequency Questionnaire (FFQ). Odds ratios and 95% CI were calculated using multinomial …

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Probing Stark-Induced Nonlinear Phase Variation With Opto-Optical Modulation, E. R. Simpson, M. Labeye, S. Camp, N. Ibrakovic, S. Bengtsson, A. Olofsson, K. J. Schafer, M. B. Gaarde, J. Mauritsson Aug 2019

Probing Stark-Induced Nonlinear Phase Variation With Opto-Optical Modulation, E. R. Simpson, M. Labeye, S. Camp, N. Ibrakovic, S. Bengtsson, A. Olofsson, K. J. Schafer, M. B. Gaarde, J. Mauritsson

Faculty Publications

We extend the recently developed technique of opto-optical modulation (OOM) to probe state-resolved ac-Stark-induced phase variations of a coherently excited ensemble of helium atoms. In a joint experimental and theoretical study, we find that the spatial redirection of the resonant emission from the OOM process is different for the low-lying 1s2p state as compared with the higher-lying Rydberg states, and that this redirection can be controlled through the spatial characteristics of the infrared (IR) probe beam. In particular, we observe that the intensity dependence of the IR-induced Stark phase on the 1s2p emission is nonlinear, and that the phase accumulation …

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Cryolipolysis: A Guide For Primary Care Practitioners, Miryam Harper, Jane H. Lassetter Aug 2019

Cryolipolysis: A Guide For Primary Care Practitioners, Miryam Harper, Jane H. Lassetter

Faculty Publications

A desire for the ideal body image has influenced the development of a nonsurgical body-shaping procedure known as cryolipolysis. The purpose of this clinical feature is to inform nurse practitioners about the risks and benefits of cryolipolysis so they can educate their patients. Cryolipolysis is a safe, effective method of reducing small areas of unwanted fat. Adverse effects are minimal and include pain, redness, bruising, and swelling. Results are seen within 12 weeks, but long-term effects are unknown. There are contraindications, and it is relatively expensive; however, it may be a safer option than invasive surgery.

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Formation Of Ultra-Diffuse Galaxies In The Field And In Galaxy Groups, Fangzhou Jiang, Avishai Dekel, Jonathan Freundlich, Aaron Romanowsky, Aaron Dutton, Andrea Macciò, Arianna Di Cintio Aug 2019

Formation Of Ultra-Diffuse Galaxies In The Field And In Galaxy Groups, Fangzhou Jiang, Avishai Dekel, Jonathan Freundlich, Aaron Romanowsky, Aaron Dutton, Andrea Macciò, Arianna Di Cintio

Faculty Publications

We study ultra-diffuse galaxies (UDGs) in zoom in cosmological simulations, seeking the origin of UDGs in the field versus galaxy groups. We find that while field UDGs arise from dwarfs in a characteristic mass range by multiple episodes of supernova feedback (Di Cintio et al.), group UDGs may also form by tidal puffing up and they become quiescent by ram-pressure stripping. The field and group UDGs share similar properties, independent of distance from the group centre. Their dark-matter haloes have ordinary spin parameters and centrally dominant dark-matter cores. Their stellar components tend to have a prolate shape with a Sérsic …

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Tutorial: Are You My Neighbor?: Bringing Order To Neighbor Computing Problems, David Anastasiu, Huzefa Rangwala, Andrea Tagarelli Aug 2019

Tutorial: Are You My Neighbor?: Bringing Order To Neighbor Computing Problems, David Anastasiu, Huzefa Rangwala, Andrea Tagarelli

Faculty Publications

Finding nearest neighbors is an important topic that has attracted much attention over the years and has applications in many fields, such as market basket analysis, plagiarism and anomaly detection, community detection, ligand-based virtual screening, etc. As data are easier and easier to collect, finding neighbors has become a potential bottleneck in analysis pipelines. Performing pairwise comparisons given the massive datasets of today is no longer feasible. The high computational complexity of the task has led researchers to develop approximate methods, which find many but not all of the nearest neighbors. Yet, for some types of data, efficient exact solutions …

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The Five Types Of Brand Hate: How They Affect Consumer Behavior, Marc Fetscherin Aug 2019

The Five Types Of Brand Hate: How They Affect Consumer Behavior, Marc Fetscherin

Faculty Publications

Drawing from Sternberg’s (2003) triangular theory of hate, this paper conceptualizes and tests the theory in the branding context. Based on two studies with 712 consumers (study 1= 349; study 2= 363) who mentioned 266 brands they hate, the authors first validate Sternberg’s (2003) theory of interpersonal hate relationships in connection with brand relationships. The empirical analyses confirm that brand hate is a multi-dimensional construct consisting of three key emotions: disgust, contempt, and anger. Our research shows there are five types of brand hate, depending on the combination of these emotions, each leading to different behavioral outcomes, including brand switching, …

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The Effects Of Oil On Blue Crab And Periwinkle Snail Interactions: A Mesocosm Study, Elizabeth M. Robinson, Nancy N. Rabalais Aug 2019

The Effects Of Oil On Blue Crab And Periwinkle Snail Interactions: A Mesocosm Study, Elizabeth M. Robinson, Nancy N. Rabalais

Faculty Publications

We examined the sub-lethal effect of Macondo oil from the Deepwater Horizon oil spill on predator-prey interactions using blue crabs (Callinectes sapidus) and periwinkle snails (Littoraria irrorata). A 2 x 2 factorial mesocosm design determined the effect of oil (no oil vs. oil) and blue crabs (no blue crab predator vs. one blue crab predator) on periwinkle snail climbing and survival. Sixteen mesocosm tanks were used in the experiment, which were replicated three times. Each tank contained water, sand, and Spartina marsh stems. The sixteen tanks were divided between two, temperature-controlled chambers to separate oil treatments (no oil vs. oil). …

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Factors Influencing Blue Carbon Accumulation Across A 32‐Year Chronosequence Of Created Coastal Marshes, Katherine M. Abbott, Tracy Elsey‐Quirk, Ronald D. Delaune Aug 2019

Factors Influencing Blue Carbon Accumulation Across A 32‐Year Chronosequence Of Created Coastal Marshes, Katherine M. Abbott, Tracy Elsey‐Quirk, Ronald D. Delaune

Faculty Publications

No abstract provided.

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Spatial Variability Of Mangrove Primary Productivity In The Neotropics, Rafaela De Albuquerque Ribeiro, André Scarlate Rovai, Robert R. Twilley, Edward Castañeda-Moya Aug 2019

Spatial Variability Of Mangrove Primary Productivity In The Neotropics, Rafaela De Albuquerque Ribeiro, André Scarlate Rovai, Robert R. Twilley, Edward Castañeda-Moya

Faculty Publications

Mangroves are considered one of the most productive ecosystems in the world with significant contributions as carbon sinks in the biosphere. Yet few attempts have been made to assess global patterns in mangrove net primary productivity, except for a few assumptions relating litterfall rates to variation in latitude. We combined geophysical and climatic variables to predict mangrove litterfall rates at continental scale. On a per-area basis, carbon flux in litterfall in the neotropics is estimated at 5 MgC·ha−1·yr−1, between 20% and 50% higher than previous estimates. Annual carbon fixed in mangrove litterfall in the neotropics is …

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High-Resolution Mapping Of Biomass And Distribution Of Marsh And Forested Wetlands In Southeastern Coastal Louisiana, Nathan Thomas, Marc Simard, Edward Castañeda-Moya, Kristin Byrd, Lisamarie Windham-Myers, Azure Bevington, Robert R. Twilley Aug 2019

High-Resolution Mapping Of Biomass And Distribution Of Marsh And Forested Wetlands In Southeastern Coastal Louisiana, Nathan Thomas, Marc Simard, Edward Castañeda-Moya, Kristin Byrd, Lisamarie Windham-Myers, Azure Bevington, Robert R. Twilley

Faculty Publications

No abstract provided.

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Remote Impacts Of Typhoons On The Hydrodynamics, Sediment Transport And Bed Stability Of An Intertidal Wetland In The Yangtze Delta, S.L. Yang, J.Q. Fan, B.W. Shi, T.J. Bouma, K.H. Xu, H.F. Yang, S.S. Zhang, Q. Zhu, X.F. Shi Aug 2019

Remote Impacts Of Typhoons On The Hydrodynamics, Sediment Transport And Bed Stability Of An Intertidal Wetland In The Yangtze Delta, S.L. Yang, J.Q. Fan, B.W. Shi, T.J. Bouma, K.H. Xu, H.F. Yang, S.S. Zhang, Q. Zhu, X.F. Shi

Faculty Publications

No abstract provided.

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Justice On The Line: Prosecutorial Screening Before Arrest, Adam M. Gershowitz Aug 2019

Justice On The Line: Prosecutorial Screening Before Arrest, Adam M. Gershowitz

Faculty Publications

Police make more than eleven million arrests every year. Yet prosecutors dismiss about 25% of criminal charges with no conviction being entered. Needless arrests are therefore clogging the criminal justice system and harming criminal defendants. For instance, Freddie Gray was fatally injured in police custody after being arrested for possession of a switchblade knife. Prosecutors later announced, however, that they did not believe the knife was actually illegal. If prosecutors had to approve warrantless arrests before police could take suspects into custody, Freddie Gray would still be alive. Yet prosecutors’ offices almost never dictate who the police should or should …

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The Nopp140 Gene In Drosophila Melanogaster Displays Length Polymorphisms In Its Large Repetitive Second Exon, Patrick J. Dimario, Sonu Shrestha Baral Aug 2019

The Nopp140 Gene In Drosophila Melanogaster Displays Length Polymorphisms In Its Large Repetitive Second Exon, Patrick J. Dimario, Sonu Shrestha Baral

Faculty Publications

Nopp140, often called the nucleolar and Cajal body phosphoprotein (NOLC1), is an evolutionarily conserved chaperone for the transcription and processing of rRNA during ribosome subunit assembly. Metazoan Nopp140 contains an amino terminal LisH dimerization domain and a highly conserved carboxyl domain. A large central domain consists of alternating basic and acidic motifs of low sequence complexity. Orthologous versions of Nopp140 contain variable numbers of repeating basic-acidic units. While vertebrate Nopp140 genes use multiple exons to encode the central domain, the Nopp140 gene in Drosophila uses exclusively exon 2 to encode the central domain. Here, we define three overlapping repeat sequence …

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Assessing The Efficiency Of Alternative Best Management Practices To Reduce Nonpoint Source Pollution In A Rural Watershed Located In Louisiana, Usa, Bijay K. Pokhrel, Krishna P. Paudel Aug 2019

Assessing The Efficiency Of Alternative Best Management Practices To Reduce Nonpoint Source Pollution In A Rural Watershed Located In Louisiana, Usa, Bijay K. Pokhrel, Krishna P. Paudel

Faculty Publications

© 2019 by the authors. We conducted biophysical simulations using MapShed to determine the effects of adopting best management practices (BMPs) to reduce nutrients and sediment pollution in a watershed dominated by poultry production in the Saline Bayou Watershed, Louisiana, USA. The reduction of three water pollutants, nitrogen, phosphorus, and sediment from adopting different BMPs were assessed using a linear programming model with the cost minimization objective. We considered three weather scenarios (dry, normal, and wet) and BMP parameter efficiencies obtained from linear regression models. Optimization results showed that nutrient management and agricultural land retirement reduced most of the phosphorus …

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Mitofusin 1 Is Required For Female Fertility And To Maintain Ovarian Follicular Reserve, Man Zhang, Muhammed Burak Bener, Zongliang Jiang, Tianren Wang, Ecem Esencan, Richard Scott, Tamas Horvath, Emre Seli Aug 2019

Mitofusin 1 Is Required For Female Fertility And To Maintain Ovarian Follicular Reserve, Man Zhang, Muhammed Burak Bener, Zongliang Jiang, Tianren Wang, Ecem Esencan, Richard Scott, Tamas Horvath, Emre Seli

Faculty Publications

© 2019, The Author(s). Mitochondria are dynamic organelles that continually adapt their structure through fusion and fission in response to changes in their bioenergetic environment. Targeted deletion of mitochondrial fusion protein mitofusin1 (MFN1) in oocytes resulted in female infertility associated with failure to achieve oocyte maturation. Oocyte-granulosa cell communication was impaired, and cadherins and connexins were downregulated, resulting in follicle developmental arrest at the secondary follicle stage. Deletion of MFN1 in oocytes resulted in mitochondrial dysfunction and altered mitochondrial dynamics, as well as accumulation of ceramide, which contributed to increased apoptosis and a reproductive phenotype that was partially rescued by …

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Wfirst And Euclid: Enabling The Microlensing Parallax Measurement From Space, Etienne Bachelet, Matthew Penny Aug 2019

Wfirst And Euclid: Enabling The Microlensing Parallax Measurement From Space, Etienne Bachelet, Matthew Penny

Faculty Publications

The Wide Field Infrared Survey Telescope (WFIRST) is expected to detect hundreds of free-floating planets, but it will not be able to measure their masses. However, simultaneous microlensing observations by both Euclid and WFIRST, separated by ∼100,000 km in orbits around the Sun-Earth L2 Lagrange point, will enable measurements of microlensing parallax for low-mass lenses such as free-floating planets. Using simple Fisher matrix estimates of the parallax measurement uncertainties, we show that high-cadence observations by Euclid could be used to measure ∼1 free-floating planet microlens parallax per 6 days of simultaneous Euclid observations. Accounting for Euclid's pointing constraints, it could …

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Exceptional Points Of Any Order In A Single, Lossy Waveguide Beam Splitter By Photon-Number-Resolved Detection, Mario A. Quiroz-Juárez, Armando Perez-Leija, Konrad Tschernig, Blas M. Rodríguez-Lara, Omar S. Magaña-Loaiza, Kurt Busch, Yogesh N. Joglekar, Roberto De J. León-Montiel Aug 2019

Exceptional Points Of Any Order In A Single, Lossy Waveguide Beam Splitter By Photon-Number-Resolved Detection, Mario A. Quiroz-Juárez, Armando Perez-Leija, Konrad Tschernig, Blas M. Rodríguez-Lara, Omar S. Magaña-Loaiza, Kurt Busch, Yogesh N. Joglekar, Roberto De J. León-Montiel

Faculty Publications

Exceptional points (EPs) are degeneracies of non-Hermitian operators where, in addition to the eigenvalues, the corresponding eigenmodes become degenerate. Classical and quantum photonic systems with EPs have attracted tremendous attention due to their unusual properties, topological features, and an enhanced sensitivity that depends on the order of the EP, i.e., the number of degenerate eigenmodes. Yet, experimentally engineering higher-order EPs in classical or quantum domains remain an open challenge due to the stringent symmetry constraints that are required for the coalescence of multiple eigenmodes. Here, we analytically show that the number-resolved dynamics of a single, lossy waveguide beam splitter, excited …

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Constraining The Nature Of The Accreting Binary In Cxogbs J174623.5-310550, M. A.P. Torres, S. Repetto, T. Wevers, M. Heida, P. G. Jonker, R. I. Hynes, G. Nelemans, Z. Kostrzewa-Rutkowska, L. Wyrzykowski, C. T. Britt, C. O. Heinke, J. Casares, C. B. Johnson, T. J. Maccarone, D. T.H. Steeghs Aug 2019

Constraining The Nature Of The Accreting Binary In Cxogbs J174623.5-310550, M. A.P. Torres, S. Repetto, T. Wevers, M. Heida, P. G. Jonker, R. I. Hynes, G. Nelemans, Z. Kostrzewa-Rutkowska, L. Wyrzykowski, C. T. Britt, C. O. Heinke, J. Casares, C. B. Johnson, T. J. Maccarone, D. T.H. Steeghs

Faculty Publications

We report optical and infrared observations of theX-ray source CXOGBS J174623.5.310550. This Galactic object was identified as a potential quiescent low-mass X-ray binary accreting from anM-type donor on the basis of optical spectroscopy and the broadHα emission line. The analysis of X-shooter spectroscopy covering three consecutive nights supports an M2/3-type spectral classification. Neither radial velocity variations nor rotational broadening is detected in the photospheric lines. No periodic variability is found in I- and r-band light curves. We derive r = 20.8, I = 19.2, and Ks ≈ 16.6 for the optical and infrared counterparts with the M-type star contributing .90 …

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Nonmonotonic Postdeglacial Relative Sea Level Changes At The Aftermath Of Marinoan (635 Ma) Snowball Earth Meltdown, Yoshiya Irie, Masao Nakada, Jun'ichi Okuno, Huiming Bao Aug 2019

Nonmonotonic Postdeglacial Relative Sea Level Changes At The Aftermath Of Marinoan (635 Ma) Snowball Earth Meltdown, Yoshiya Irie, Masao Nakada, Jun'ichi Okuno, Huiming Bao

Faculty Publications

© 2019. American Geophysical Union. All Rights Reserved. Marinoan snowball Earth offers us a set of sedimentary and geochemical records for exploring glacial isostatic adjustment (GIA) associated with one of the most severe glaciations in Earth history. An accurate prediction of GIA-based relative sea level (RSL) change associated with a snowball Earth meltdown will help to explore sedimentary records for RSL changes and to place independent constraints on mantle viscosity and on the durations of syndeglaciation (Td) and cap carbonate deposition. Here we mainly examine postdeglacial RSL change characterized by an RSL drop and a resumed transgression inferred from the …

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Synergistic Effects Of Temperature And Salinity On The Gene Expression And Physiology Of Crassostrea Virginica, H. R. Jones, K. M. Johnson, M. W. Kelly Aug 2019

Synergistic Effects Of Temperature And Salinity On The Gene Expression And Physiology Of Crassostrea Virginica, H. R. Jones, K. M. Johnson, M. W. Kelly

Faculty Publications

© 2019 The Author(s). The eastern oyster, Crassostrea virginica, forms reefs that provide critical services to the surrounding ecosystem. These reefs are at risk from climate change, in part because altered rainfall patterns may amplify local fluctuations in salinity, impacting oyster recruitment, survival, and growth. As in other marine organisms, warming water temperatures might interact with these changes in salinity to synergistically influence oyster physiology. In this study, we used comparative transcriptomics, measurements of physiology, and a field assessment to investigate what phenotypic changes C. virginica uses to cope with combined temperature and salinity stress in the Gulf of Mexico. …

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Light-Induced Release Of Nitric Oxide From The Nitric Oxide-Bound Cdgsh-Type [2fe–2s] Clusters In Mitochondrial Protein Miner2, Yiming Wang, Jeonghoon Lee, Huangen Ding Aug 2019

Light-Induced Release Of Nitric Oxide From The Nitric Oxide-Bound Cdgsh-Type [2fe–2s] Clusters In Mitochondrial Protein Miner2, Yiming Wang, Jeonghoon Lee, Huangen Ding

Faculty Publications

© 2019 Elsevier Inc. Human mitochondrial matrix protein Miner2 hosts two [2Fe–2S] clusters via two CDGSH (Cys-Asp-Gly-Ser-His) motifs. Unlike other iron-sulfur clusters in proteins, the reduced CDGSH-type [2Fe–2S] clusters in Miner2 are able to bind nitric oxide (NO) and form stable NO-bound [2Fe–2S] clusters without disruption of the clusters. Here we report that the NO-bound Miner2 [2Fe–2S] clusters can quickly release NO upon the visible light excitation. The UV–visible and Electron Paramagnetic Resonance (EPR) measurements show that the NO-bound Miner2 [2Fe–2S] clusters are converted to the reduced Miner2 [2Fe–2S] clusters upon the light excitation under anaerobic conditions, suggesting that NO …

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The Association Between Cardiovascular Disease Risk Factors And 25-Hydroxivitamin D And Related Analytes Among Hispanic/Latino Adults: A Pilot Study, Ramon A. Durazo-Arvizu, Reyna L. Pacheco-Dominguez, Christopher T. Sempos, Holly Kramer, Andrew N. Hoofnagle, Amber Pirzada, Richard S. Cooper, Martha L. Daviglus Aug 2019

The Association Between Cardiovascular Disease Risk Factors And 25-Hydroxivitamin D And Related Analytes Among Hispanic/Latino Adults: A Pilot Study, Ramon A. Durazo-Arvizu, Reyna L. Pacheco-Dominguez, Christopher T. Sempos, Holly Kramer, Andrew N. Hoofnagle, Amber Pirzada, Richard S. Cooper, Martha L. Daviglus

Faculty Publications

Although the association of vitamin D levels with cardiovascular risk profiles among Hispanics/Latinos has been studied, little is known about this association among Hispanics/Latinos with chronic conditions. This pilot study determined serum vitamin D and parathyroid hormone (PTH) levels in a sample of participants from the University of Illinois at the Chicago Cohort of Patients, Family and Friends (UIC Cohort) and examined their association with traditional cardiovascular disease risk factors. From July 2012 to June 2016, the UIC Cohort study enrolled and conducted clinical examinations on men and women ages 18 years and older, who had one or more diagnosed …

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A Multi-Ancestry Genome-Wide Study Incorporating Gene-Smoking Interactions Identifies Multiple New Loci For Pulse Pressure And Mean Arterial Pressure, Yun Ju Sung, Lisa De Las Fuentes, Thomas W. Winkler, Daniel I. Chasman, Amy R. Bentley, Aldi T. Kraja, Ioanna Ntalla, Helen R. Warren, Xiuqing Guo, Karen Schwander, Alisa K. Manning, Michael R. Brown, Hugues Aschard, Mary F. Feitosa, Nora Franceschini, Yingchang Lu, Ching Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Tuomas O. Kilpeläinen, Melissa A. Richard, Stella Aslibekyan, Traci M. Bartz, Rajkumar Dorajoo, Changwei Li, Yongmei Liu, Tuomo Rankinen, Albert Vernon Smith, Salman M. Tajuddin, Bamidele O. Tayo, Wei Zhao Aug 2019

A Multi-Ancestry Genome-Wide Study Incorporating Gene-Smoking Interactions Identifies Multiple New Loci For Pulse Pressure And Mean Arterial Pressure, Yun Ju Sung, Lisa De Las Fuentes, Thomas W. Winkler, Daniel I. Chasman, Amy R. Bentley, Aldi T. Kraja, Ioanna Ntalla, Helen R. Warren, Xiuqing Guo, Karen Schwander, Alisa K. Manning, Michael R. Brown, Hugues Aschard, Mary F. Feitosa, Nora Franceschini, Yingchang Lu, Ching Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Tuomas O. Kilpeläinen, Melissa A. Richard, Stella Aslibekyan, Traci M. Bartz, Rajkumar Dorajoo, Changwei Li, Yongmei Liu, Tuomo Rankinen, Albert Vernon Smith, Salman M. Tajuddin, Bamidele O. Tayo, Wei Zhao

Faculty Publications

Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through …

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From Pampa To Puna: Biogeography And Diversification Of A Group Of Neotropical Obligate Grassland Birds (Anthus: Motacillidae), Paul Van Els Aug 2019

From Pampa To Puna: Biogeography And Diversification Of A Group Of Neotropical Obligate Grassland Birds (Anthus: Motacillidae), Paul Van Els

Faculty Publications

The evolution of Neotropical birds of open landscapes remains largely unstudied. We investigate the diversification and biogeography of a group of Neotropical obligate grassland birds (Anthus: Motacillidae). We use a multilocus phylogeny of 22 taxa of Anthus to test the hypothesis that these birds radiated contemporaneously with the development of grasslands in South America. We employ the R package DDD to analyze the dynamics of Anthus diversification across time in Neotropical grasslands, explicitly testing for shifts in dynamics associated with the Miocene development of grasslands, the putative Pleistocene expansion of arid lowland biomes, and Pleistocene sundering of Andean highland grasslands. …

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Internally 4-Connected Binary Matroids With Every Element In Three Triangles, Carolyn Chun, James Oxley Aug 2019

Internally 4-Connected Binary Matroids With Every Element In Three Triangles, Carolyn Chun, James Oxley

Faculty Publications

Let M be an internally 4-connected binary matroid with every element in exactly three triangles. Then M has at least four elements e such that si(M/e) is internally 4-connected. This technical result is a crucial ingredient in Abdi and Guenin’s theorem determining the minimally non-ideal binary clutters that have a triangle.

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Dynamics Of Liposomes In The Fluid Phase, Sudipta Gupta, Judith U. De Mel, Gerald J. Schneider Aug 2019

Dynamics Of Liposomes In The Fluid Phase, Sudipta Gupta, Judith U. De Mel, Gerald J. Schneider

Faculty Publications

© 2019 Elsevier Ltd We review the currently available material on the morphology and dynamics of phospholipids assembled into liposomes. Key information obtained from neutron scattering, nuclear magnetic resonance (NMR), and other techniques plays a crucial role in understanding the vital role of lipids in sustaining life in living organisms. We concentrate on the dynamics in the biologically important fluid phase in the time range from picoseconds to seconds, which includes a discussion of the center of mass diffusion of liposomes, membrane fluctuations; and lateral, rotational, and flip-flop motions of the lipids. We emphasize on the sensitivity of the dynamics …

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Review Of I Heart Oklahoma, Michael F. Russo Aug 2019

Review Of I Heart Oklahoma, Michael F. Russo

Faculty Publications

No abstract provided.

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Flood Protection Ecosystem Services In The Coast Of Puerto Rico: Associations Between Extreme Weather, Flood Hazard Mitigation And Gastrointestinal Illness, R. De Jesus Crespo, J. Wu, M. Myer, S. Yee, R. Fulford Aug 2019

Flood Protection Ecosystem Services In The Coast Of Puerto Rico: Associations Between Extreme Weather, Flood Hazard Mitigation And Gastrointestinal Illness, R. De Jesus Crespo, J. Wu, M. Myer, S. Yee, R. Fulford

Faculty Publications

No abstract provided.

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Bluebills And Bayou Bivalves: Hurricane-Driven Trophic Cascades Affect Wintering Abundance Of Lesser Scaup In Louisiana, Clay M. Stroud, Claire E. Caputo, Michael A. Poirrier, Larry A. Reynolds, Kevin M. Ringelman Aug 2019

Bluebills And Bayou Bivalves: Hurricane-Driven Trophic Cascades Affect Wintering Abundance Of Lesser Scaup In Louisiana, Clay M. Stroud, Claire E. Caputo, Michael A. Poirrier, Larry A. Reynolds, Kevin M. Ringelman

Faculty Publications

The estuaries of coastal Louisiana overwinter a continentally significant proportion of Lesser Scaup (Aythya affinis; colloquially, “bluebills”), a migratory bird species of conservation concern since population declines began in the 1980s. Thirty-eight years of aerial waterfowl surveys of Lake Pontchartrain—an oligohaline estuarine lagoon in southeast Louisiana—show that scaup abundance fluctuates between 0 and 1,194,907 birds, though the mechanisms driving this variation are unknown. Previous studies have shown that scaup feed primarily on mollusks, and so changes in the benthic prey community have the potential to strongly influence scaup dynamics on the Lake. Benthic communities are in turn shaped by both …

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