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The Legal Subject And The Judicialization Of French Civic Culture: Fin De Siècle Roots Of Contemporary Politics, John J. Cerullo Jan 2005

The Legal Subject And The Judicialization Of French Civic Culture: Fin De Siècle Roots Of Contemporary Politics, John J. Cerullo

Faculty Publications

No abstract provided.

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Spatial Distribution Of Land Type In Regression Models Of Pollutant Loading, Evan J. Fedorko, Robert Gilmore Pontius Jr., Stephen P. Aldrich, Luc Claussens, Charles S. Hopkinson, Wilfred M. Wollheim Jan 2005

Spatial Distribution Of Land Type In Regression Models Of Pollutant Loading, Evan J. Fedorko, Robert Gilmore Pontius Jr., Stephen P. Aldrich, Luc Claussens, Charles S. Hopkinson, Wilfred M. Wollheim

Faculty Publications

This paper proposes a method to improve landscape-pollution interaction regression models through the inclusion of a variable that describes the spatial distribution of a land type with respect to the pattern of runoff within a drainage catchment. The proposed index is used as an independent variable to enhance the strength, as quantified by R² values, of regression relationships between empirical observations of in-stream pollutant concentrations and land type by considering the spatial distribution of key land-type categories within the sample point’s drainage area. We present an index that adds a new dimension of explanatory power when used in conjunction with …

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Early Blue Crab Recruitment To Alternative Nursery Habitats In Mississippi, Usa, Chet R. Rakocinski, Donna Drury Mccall Jan 2005

Early Blue Crab Recruitment To Alternative Nursery Habitats In Mississippi, Usa, Chet R. Rakocinski, Donna Drury Mccall

Faculty Publications

Although seagrass in the lower segments of estuaries provides good nursery habitat for blue crabs, the role of alternative inshore habitats for early blue crab recruitment is not well-known. Using suction sampling, we examined the recruitment dynamics of early blue crabs (Callinectes spp.) over a 10-wk study period at 7 sites representing potential nursery habitats, including 2 marsh edge sites, 2 subtidal unvegetated sites adjacent to salt marsh, 2 subtidal unvegetated sites adjacent to developed marsh, and 1 upestuary subtidal vegetated site. Abundances of small (< 6.0 mm CW) and large (&GE; 6.0 mm) juvenile crabs varied over the study period, mainly reflecting two monthly pulses of small crabs coinciding with the new moon phase. Early crabs were Significantly more abundant from structured habitats than from subtidal unvegetated habitat; although small crabs were moderately abundant at subtidal unvegetated sites situated lower in the estuary. Large crabs were not abundant from subtidal unvegetated sites; whereas large crabs were abundant from sites with structured habitat. Subtidal unvegetated sites were characterized by crab size-distributions with single modes representing postsettlement crabs and with few large crabs; whereas structured habitats contained relatively more large crabs. However, crab size-distributions varied among structured habitats. Spatio-temporal variation in the early recruitment dynamics of blue crabs reflected temporal changes, such as lunar periodicity; landscape effects, such as proximity to currents; and habitat effects.

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Preserving A Precious Resource: Rationalizing The Use Of Antibiotics, Eric Kades Jan 2005

Preserving A Precious Resource: Rationalizing The Use Of Antibiotics, Eric Kades

Faculty Publications

No abstract provided.

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Judicial Federalism And The Future Of Federal Environmental Regulation, Jonathan H. Adler Jan 2005

Judicial Federalism And The Future Of Federal Environmental Regulation, Jonathan H. Adler

Faculty Publications

This article assesses the current and likely impact of the Supreme Court's federalism cases on federal environmental regulation. As a result of this assessment, the article seeks to make four points: (1) Thus far, the Supreme Court's federalism cases have had a limited impact on federal regulation, as federal courts have not used these cases as a basis for limiting the reach of federal regulatory authority. (2) Notwithstanding this limited impact, the underlying logic of the Supreme Court's cases does pose a challenge for federal regulation, particularly in the Commerce Clause context. (3) The thrust of the federalism cases makes …

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His Story/Her Story: A Dialogue About Including Men And Masculinities In The Women’S Studies Curriculum, B. Berila, J. Keller, C. Krone, Jason A. Laker, O. Mayers Jan 2005

His Story/Her Story: A Dialogue About Including Men And Masculinities In The Women’S Studies Curriculum, B. Berila, J. Keller, C. Krone, Jason A. Laker, O. Mayers

Faculty Publications

The article discusses the issue of inclusion of men and masculinities in the Women's Studies curriculum. Women's Studies programs were started to compensate for the male domination in the academics. Women's Studies presented a platform where scholarship for women was produced and taken seriously, female students and faculty could find their say or voice, and theoretical investigations required for the advancement of the aims of the women's movement could take place. If the academy as a whole does not sufficiently integrate Women's Studies into the curriculum, integrating Men's Studies into Women's Studies might end up further marginalizing Women's Studies by …

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Accumulation Of Retinol In The Liver After Prolonged Hyporetinolemia In The Vitamin A-Sufficient Rat, Sin Gieng, Jens Raila, Francisco Rosales Jan 2005

Accumulation Of Retinol In The Liver After Prolonged Hyporetinolemia In The Vitamin A-Sufficient Rat, Sin Gieng, Jens Raila, Francisco Rosales

Faculty Publications

We assessed the effects of prolonged reduction of plasma retinol concentrations (hyporetinolemia) on the distribution of tissue vitamin A (VA) and of its active compounds using a model of continuous recombinant human interleukin-6 (rhIL-6) infusion via osmotic minipumps in VA-sufficient male rats. Plasma retinol and retinol-binding protein (RBP) concentrations remained decreased and lower in rhIL-6-treated rats compared with controls from 7.5 h throughout 7 days of infusion (P < 0.001). This reduction was accompanied by a 68% increase in hepatic retinol concentration by 7 days (P < 0.05). Hepatic and renal retinyl palmitate and retinoic acid concentrations did not change, and renal megalin content remained unchanged; hepatic RBP concentrations were 41% lower in rhIL-6-treated rats compared with controls (P < 0.05). These results indicate that instead of being lost, retinol accumulated in the liver during inflammation and that hyporetinolemia was attributable to a decrease in the availability of hepatic RBP. A plausible consequence of the effect of rhIL-6-induced hyporetinolemia is that by 7 days tissues that are dependent on plasma retinol may become deprived of VA.These results have important implications in understanding the mechanism by which measles infection induces hyporetinolemia and VA deficiency of extrahepatic tissues.

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Little Sisters: An Exploration Of Agency, Cultural Borderlands, And Institutional Constraints In The Lives Of Two Teenage Girls, Rosemary C. Henze Jan 2005

Little Sisters: An Exploration Of Agency, Cultural Borderlands, And Institutional Constraints In The Lives Of Two Teenage Girls, Rosemary C. Henze

Faculty Publications

Part of a special issue on challenging corporate control of schools and communities. The writer discusses her experience with the Big Brothers and Big Sisters organization in Oakland, California, of mentoring two teenage girls who live in poverty and encounter crises and hardship almost daily. She examines the concepts of agency and social and cultural borderlands to help explain the divergent school performances of the two girls and investigates the concepts' utility in the pursuit of social justice for young women. She conducts her exploration within the broader context of dynamic change.

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An Experimental Study Of Substrate Selection In American Toad (Bufo Americanus) Metamorphs, Geoffrey R. Smith Jan 2005

An Experimental Study Of Substrate Selection In American Toad (Bufo Americanus) Metamorphs, Geoffrey R. Smith

Faculty Publications

No abstract provided.

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Survivorship Of Xenosaurus Newmanorum (Sauria: Xenosauridae) From A Seasonal Tropical Environment In Mexico, J. A. Lemos-Espinal, Geoffrey R. Smith, R. E. Ballinger Jan 2005

Survivorship Of Xenosaurus Newmanorum (Sauria: Xenosauridae) From A Seasonal Tropical Environment In Mexico, J. A. Lemos-Espinal, Geoffrey R. Smith, R. E. Ballinger

Faculty Publications

No abstract provided.

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Complexity Theory, Adaptation, And Administrative Law, Donald Thomas Hornstein Jan 2005

Complexity Theory, Adaptation, And Administrative Law, Donald Thomas Hornstein

Faculty Publications

No abstract provided.

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Seasonal Acceptance Of Fourwing Saltbush By Sheep When Crested Wheatgrass Is The Alternative, Val J. Anderson, R. D. Horrocks, Christine W. Royer, Stephen B. Monsen Jan 2005

Seasonal Acceptance Of Fourwing Saltbush By Sheep When Crested Wheatgrass Is The Alternative, Val J. Anderson, R. D. Horrocks, Christine W. Royer, Stephen B. Monsen

Faculty Publications

Many sagebrush-grass ranges have been seeded to crested wheatgrass [Agropyron desertorum (Fischer ex Link) Shultes]. These ranges are generally nutritionally inadequate for sheep (Ovis aries L.), except for short grazing periods in the spring and fall. To increase production and diversity, particularly crude protein for late-season grazing, fourwing saltbush [Atriplex canescens (Pursch.) Nutt.] was planted in an existing stand of crested wheatgrass. Quantification of sheep forage preferences on these improved ranges aids in determining the length of the grazing season and the extent to which shrubs provide the supplemental nutrition required. This seasonal grazing study was conducted on a characteristic …

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Arrival Timing And Seasonal Reproductive Performance In A Long-Distance Migratory Landbird, Robert J. Smith, Frank R. Moore Jan 2005

Arrival Timing And Seasonal Reproductive Performance In A Long-Distance Migratory Landbird, Robert J. Smith, Frank R. Moore

Faculty Publications

The date when a landbird migrant arrives on its breeding grounds may have reproductive consequences. Generally, early arriving individuals begin breeding earlier and consequently experience greater seasonal reproductive performance. Here, we describe relationships between arrival timing and seasonal reproductive performance in the American redstart (Setophaga ruticilla), a long-distance passerine migrant, arriving at northerly breeding grounds in Michigan’s eastern Upper Peninsula. Evidence suggests that both males and females benefited from early arrival at the breeding grounds. Early males appeared to settle on higher quality territories and hatched nestlings sooner than later arrivals. Early females began their clutches early, produced …

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Genocide And The Eroticization Of Death: Law, Violence, And Moral Purity, Tawia Baidoe Ansah Jan 2005

Genocide And The Eroticization Of Death: Law, Violence, And Moral Purity, Tawia Baidoe Ansah

Faculty Publications

In this article, I ask: What is the relationship between law and morality in response to mass violence and suffering abroad? How does law shape and determine our moral response to mass death and suffering? We repose in the law itself a desire to define the moral and the ethical parameters of legal-political action. Thus, when faced with mass violence and suffering abroad, law functions as a proxy for morality. The legal prohibition under the Genocide Convention defines morality, or cabins the variety of moral responses into a single and universally applicable ethical-legal norm of response to genocide. The moral …

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Thorium-Based Thin Films As Highly Reflective Mirrors In The Euv, David D. Allred, William R. Evans, Jed E. Johnson, Richard L. Sandberg, R. Steven Turley Jan 2005

Thorium-Based Thin Films As Highly Reflective Mirrors In The Euv, David D. Allred, William R. Evans, Jed E. Johnson, Richard L. Sandberg, R. Steven Turley

Faculty Publications

As applications for extreme ultraviolet (EUV) radiation have been identified, the demand for better optics has also increased. Thorium and thorium oxide thin films (19 to 61 nm thick) were RF-sputtered and characterized using atomic force microscopy (AFM), spectroscopic ellipsometry, low-angle x-ray diffraction (LAXRD), x-ray photoelectron spectroscopy (XPS), and x-ray absorption near edge structure (XANES) in order to assess their capability as EUV reflectors. Their reflectance and absorption at different energies were also measured and analyzed at the Advanced Light Source in Berkeley. The reflectance of oxidized thorium is reported between 2 and 32 nm at 5, 10, and 15 …

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Genetic Variation In Ustilago Bullata: Molecular Genetic Markers And Virulence On Bromus Tectorum Host Lines, Mikel Stevens, Daniel J. Fairbanks, Susan E. Meyer, David L. Nelson, Suzette Clement, Jennifer Waters Jan 2005

Genetic Variation In Ustilago Bullata: Molecular Genetic Markers And Virulence On Bromus Tectorum Host Lines, Mikel Stevens, Daniel J. Fairbanks, Susan E. Meyer, David L. Nelson, Suzette Clement, Jennifer Waters

Faculty Publications

The pathogen Ustilago bullata often causes epidemic levels of head smut disease in Intermountain populations of the inbreeding annual grass Bromus tectorum. We examined patterns of genetic variation for virulence and for amplified fragment length polymorphism (AFLP) markers in four U. bullata populations on B. tectorum in northern Utah and southern Nevada. Patterns of disease incidence generally supported a genefor-gene model for virulence and resistance in this pathosystem. Most host lines were susceptible to most or all paired isolates included in cross-inoculation tests, but we found evidence for the existence of four avirulence genes. Host lines with alleles conferring resistance …

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Recognition Of Affective Prosody By Speakers Of English As A First Or Foreign Language, Christopher Dromey, Jose Silveira, Paul Sandor Jan 2005

Recognition Of Affective Prosody By Speakers Of English As A First Or Foreign Language, Christopher Dromey, Jose Silveira, Paul Sandor

Faculty Publications

Adults who were fluent in English, and who grew up speaking English or one of 21 other languages listened to words spoken with angry or neutral intonation. We measured the accuracy with which the listeners identified the intended emotion. English mother tongue (EMT) polyglots scored higher than other mother tongue (OMT) listeners, whereas EMT monoglots did not. Women were significantly more accurate than men across the three listener groups. There was a modest inverse correlation between accuracy and age. The learning of a second language may have helped the EMT polyglots develop additional perceptual skills in decoding speech emotion in …

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Leadership, Collective Personality, And Performance, David A. Hofmann, Lisa Jones Christensen Jan 2005

Leadership, Collective Personality, And Performance, David A. Hofmann, Lisa Jones Christensen

Faculty Publications

By viewing behavior regularities at the individual and collective level as functionally isomorphic, a referent-shift compositional model for the Big 5 personality dimensions is developed. On the basis of this compositional model, a common measure of Big 5 personality at the individual level is applied to the collective as a whole. Within this framework, it is also hypothesized that leadership (i.e., transformational, transactional, and passive) would predict collective personality and that collective personality would be significantly related to collective performance. The results supported these hypotheses using a sample of franchised units. On the basis of recent research at the individual …

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Habitat Patch Occupancy Dynamics Of Glaucous-Winged Gulls (Larus Glaucescens) Ii: A Continuous-Time Model, Smruti P. Damania, Karl W. Phillips, Shandelle M. Henson, James L. Hayward Jan 2005

Habitat Patch Occupancy Dynamics Of Glaucous-Winged Gulls (Larus Glaucescens) Ii: A Continuous-Time Model, Smruti P. Damania, Karl W. Phillips, Shandelle M. Henson, James L. Hayward

Faculty Publications

The diurnal distribution and abundance dynamics of loafing Glaucous-winged Gulls (Larus glaucescens) were examined at Protection Island National Wildlife Refuge, Strait of Juan de Fuca, Washington. Asynchronous movement of gulls among three habitat patches dedicated to loafing was modeled as a function of environmental variables using differential equations. Multiple time scale analysis led to the derivation of algebraic models for habitat patch occupancy dynamics. The models were parameterized with hourly census data collected from each habitat patch, and the resulting model predictions were compared with observed census data. A four-compartment model explained 41% of the variability in the data. Models …

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Habitat Patch Occupancy Dynamics Of Glaucous-Winged Gulls (Larus Glaucescens) I: A Discrete-Time Model, Karl W. Phillips, Smruti P. Damania, James L. Hayward, Shandelle M. Henson, Clara J. Logan Jan 2005

Habitat Patch Occupancy Dynamics Of Glaucous-Winged Gulls (Larus Glaucescens) I: A Discrete-Time Model, Karl W. Phillips, Smruti P. Damania, James L. Hayward, Shandelle M. Henson, Clara J. Logan

Faculty Publications

Diurnal habitat occupancy dynamics of Glaucous-winged Gulls were evaluated in a system of six habitats on and around Protection Island, Washington. Data were collected on the rates of gull movement between habitat patches, and from these data the probabilities of transitions between habitats were estimated as functions of tide height and time of day. A discrete-time matrix model based on the transition probabilities was used to generate habitat occupancy predictions, which were then compared to hourly census data. All model parameters were estimated directly from data rather than through model fitting. The model made reasonable predictions for two of the …

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Shared Experience Building Around The Family Crucible Of Cancer, W. David Robinson, Jason S. Carroll, Wendy L. Watson Jan 2005

Shared Experience Building Around The Family Crucible Of Cancer, W. David Robinson, Jason S. Carroll, Wendy L. Watson

Faculty Publications

This study was designed to gain a greater understanding of the effects cancer has on families while simultaneously developing family therapy interventions that are helpful for families experiencing the crucible of cancer. On the basis of an action research paradigm, the authors designed an intensive case-analysis protocol involving reflective interviewing to learn about the personal perspectives of family members who participate in therapeutic treatment for cancer. An integration of reflective insight by the families, their therapist, and the research team ultimately revealed that cancer families face an ongoing struggle (a) between feelings of isolation and connectedness, (b) to make meaning …

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The Saccharomyces Cerevisiae High Mobility Group Box Protein Hmo1 Contains Two Functional Dna Binding Domains, Edwin Kamau, Kevin T. Bauerle, Anne Grove Dec 2004

The Saccharomyces Cerevisiae High Mobility Group Box Protein Hmo1 Contains Two Functional Dna Binding Domains, Edwin Kamau, Kevin T. Bauerle, Anne Grove

Faculty Publications

High mobility group box (HMGB) proteins are architectural proteins whose HMG DNA binding domains confer significant preference for distorted DNA, such as 4-way junctions. HMO1 is one of 10 Saccharomyces cerevisiae HMGB proteins, and it is required for normal growth and plasmid maintenance and for regulating the susceptibility of yeast chromatin to nuclease. Using electrophoretic mobility shift assays, we have shown here that HMO1 binds 26-bp duplex DNA with K d = 39.6 ± 5.0 nM and that its divergent box A domain participates in DNA interactions, albeit with low affinity. HMO1 has only modest preference for DNA with altered …

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The Relative Influence Of Metal Ion Binding Sites In The I-Like Domain And The Interface With The Hybrid Domain On Rolling And Firm Adhesion By Integrin Α4Β7, Jian Feng Chen, Junichi Takagi, Can Xie, Tsan Xiao, Bing Hao Luo, Timothy A. Springer Dec 2004

The Relative Influence Of Metal Ion Binding Sites In The I-Like Domain And The Interface With The Hybrid Domain On Rolling And Firm Adhesion By Integrin Α4Β7, Jian Feng Chen, Junichi Takagi, Can Xie, Tsan Xiao, Bing Hao Luo, Timothy A. Springer

Faculty Publications

We examined the effect of conformational change at the β7 I-Iike/hybrid domain interface on regulating the transition between rolling and firm adhesion by integrin α4β7. An N-glycosylation site was introduced into the I-like/hybrid domain interface to act as a wedge and to stabilize the open conformation of this interface and hence the open conformation of the α4β7 headpiece. Wild-type α4β7 mediates rolling adhesion in Ca2+ and Ca2+/Mg2+ but firm adhesion in Mg2+ and Mn2+. Stabilizing the open headpiece resulted in firm adhesion in all divalent cations. The interaction between metal binding sites in the I-like domain and the interface with …

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Toward A Systems Approach To Understanding Plant Cell Walls, Chris Somerville, Stefan Bauer, Ginger Brininstool, Michelle Facette, Thorsten Hamann, Jennifer Milne, Erin Osborne, Alex Paredez, Staffan Persson, Ted Raab, Sonja Vorwerk, Heather Youngs Dec 2004

Toward A Systems Approach To Understanding Plant Cell Walls, Chris Somerville, Stefan Bauer, Ginger Brininstool, Michelle Facette, Thorsten Hamann, Jennifer Milne, Erin Osborne, Alex Paredez, Staffan Persson, Ted Raab, Sonja Vorwerk, Heather Youngs

Faculty Publications

One of the defining features of plants is a body plan based on the physical properties of cell walls. Structural analyses of the polysaccharide components, combined with high-resolution imaging, have provided the basis for much of the current understanding of cell walls. The application of genetic methods has begun to provide new insights into how walls are made, how they are controlled, and how they function. However, progress in integrating biophysical, developmental, and genetic information into a useful model will require a system-based approach.

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Dietary Isoflavones Alter Regulatory Behaviors, Metabolic Hormones And Neuroendocrine Function In Long-Evans Male Rats, Edwin D. Lephart, James P. Proter, Lihong H. Bu, Trent D. Lund, Kenneth Setchell, Gina Ramoz, William R. Crowley Dec 2004

Dietary Isoflavones Alter Regulatory Behaviors, Metabolic Hormones And Neuroendocrine Function In Long-Evans Male Rats, Edwin D. Lephart, James P. Proter, Lihong H. Bu, Trent D. Lund, Kenneth Setchell, Gina Ramoz, William R. Crowley

Faculty Publications

Phytoestrogens derived from soy foods (or isoflavones) have received prevalent usage due to their 'health benefits' of decreasing: a) age-related diseases, b) hormone-dependent cancers and c) postmenopausal symptoms. However, little is known about the influence of dietary phytoestrogens on regulatory behaviors, such as food and water intake, metabolic hormones and neuroendocrine parameters. This study examined important hormonal and metabolic health issues by testing the hypotheses that dietary soy-derived isoflavones influence: 1) body weight and adipose deposition, 2) food and water intake, 3) metabolic hormones (i.e., leptin, insulin, T3 and glucose levels), 4) brain neuropeptide Y (NPY) levels, 5) heat production …

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Genome Sequence Of Silicibacter Pomeroyi Reveals Adaptations To The Marine Environment, Mary Ann Moran, Alison Buchan, José M. González, John F. Heidelberg, William B. Whitman, Ronald P. Klene, James R. Henriksen, Gary M. King, Robert Belas, Clay Fuqua, Lauren Brinkac, Matt Lewis, Shivani Johri, Bruce Weaver, Grace Pai, Jonathan A. Elsen, Elisha Rahe, Wade M. Sheldon, Wenying Ye, Todd R. Miller, Jane Carlton, David A. Rasko, Ian T. Paulsen, Qinghu Ren, Sean C. Daugherty, Ribert T. Deboy, Robert J. Dodson, A. Scott Durkin, Ramana Madupu, William C. Nelson, Steven A. Sullivan, M. J. Rosovitz, Daniel H. Haft Dec 2004

Genome Sequence Of Silicibacter Pomeroyi Reveals Adaptations To The Marine Environment, Mary Ann Moran, Alison Buchan, José M. González, John F. Heidelberg, William B. Whitman, Ronald P. Klene, James R. Henriksen, Gary M. King, Robert Belas, Clay Fuqua, Lauren Brinkac, Matt Lewis, Shivani Johri, Bruce Weaver, Grace Pai, Jonathan A. Elsen, Elisha Rahe, Wade M. Sheldon, Wenying Ye, Todd R. Miller, Jane Carlton, David A. Rasko, Ian T. Paulsen, Qinghu Ren, Sean C. Daugherty, Ribert T. Deboy, Robert J. Dodson, A. Scott Durkin, Ramana Madupu, William C. Nelson, Steven A. Sullivan, M. J. Rosovitz, Daniel H. Haft

Faculty Publications

Since the recognition of prokaryotes as essential components of the oceanic food web1, bacterioplankton have been acknowledged as catalysts of most major biogeochemical processes in the sea. Studying heterotrophic bacterioplankton has been challenging, however, as most major clades have never been cultured2 or have only been grown to low densities in sea water3,4. Here we describe the genome sequence of Silicibacter pomeroyi, a member of the marine Roseobacter clade (Fig. 1), the relatives of which comprise ∼10-20% of coastal and oceanic mixed-layer bacterioplankton2,5,6,7. This first genome sequence from any major heterotrophic clade consists of a chromosome (4,109,442 base pairs) and …

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Hucr, A Novel Uric Acid-Responsive Member Of The Marr Family Of Transcriptional Regulators From Deinococcus Radiodurans, Steven P. Wilkinson, Anne Grove Dec 2004

Hucr, A Novel Uric Acid-Responsive Member Of The Marr Family Of Transcriptional Regulators From Deinococcus Radiodurans, Steven P. Wilkinson, Anne Grove

Faculty Publications

The MarR family of transcriptional regulators comprises a subset of winged helix DNA-binding proteins and includes numerous members that function in environmental surveillance of aromatic compounds. We describe the characterization of HucR, a novel MarR homolog from Deinococcus radiodurans that demonstrates phenolic sensing capabilities. HucR binds as a homodimer to a single site within its promoter/operator region with Kd = 0.29 ± 0.02 nM. The HucR binding site contains a pseudopalindromic sequence, composed of 8-bp half-sites separated by 2 bp. The location of the HucR binding site in the intergenic region between hucR and a putative uricase suggests a mechanism …

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Dominant-Negative Creb Inhibits Heparanase Functionality And Melanoma Cell Invasion, Rebecca Aucoin, Jane Reiland, Madhuchhanda Roy, Dario Marchetti Dec 2004

Dominant-Negative Creb Inhibits Heparanase Functionality And Melanoma Cell Invasion, Rebecca Aucoin, Jane Reiland, Madhuchhanda Roy, Dario Marchetti

Faculty Publications

Heparanase (HPSE-1) is an endo-β-D-glucuronidase involved in the degradation of cell-surface/extracellular matrix heparan sulfate (HS) in normal and neoplastic tissues. HPSE-1 represents the first example of purification and cloning of a mammalian HS-degradative enzyme. Elevated HPSE-1 levels are known to be associated with metastatic cancers, directly implicating HPSE-1 in metastatic events. The purpose of this study was to determine the role of cAMP response element-binding protein (CREB) in modulating HPSE-1-mediated effects on human melanoma cell invasion. Highly invasive, brain-metastatic melanoma cells (70W) were transfected with the dominant-negative CREB (KCREB) and subsequently analyzed for changes in their HPSE-1 content, functionality, and …

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Fragile Fiber3, An Arabidopsis Gene Encoding A Type Ii Inositol Polyphosphate 5-Phosphatase, Is Required For Secondary Wall Synthesis And Actin Organization In Fiber Cells, Ruiqin Zhong, David H. Burk, W. Herbert Morrison, Zheng Hua Ye Dec 2004

Fragile Fiber3, An Arabidopsis Gene Encoding A Type Ii Inositol Polyphosphate 5-Phosphatase, Is Required For Secondary Wall Synthesis And Actin Organization In Fiber Cells, Ruiqin Zhong, David H. Burk, W. Herbert Morrison, Zheng Hua Ye

Faculty Publications

Type II inositol polyphosphate 5-phosphatases (5PTases) in yeast and animals have been known to regulate the level of phosphoinositides and thereby influence various cellular activities, such as vesicle trafficking and actin organization. In plants, little is known about the phosphatases involved in hydrolysis of phosphoinositides, and roles of type II 5PTases in plant cellular functions have not yet been characterized. In this study, we demonstrate that the FRAGILE FIBER3 (FRA3) gene of Arabidopsis thaliana, which encodes a type II 5PTase, plays an essential role in the secondary wall synthesis in fiber cells and xylem vessels. The fra3 mutations caused a …

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The Malic Enzyme Is Required For Optimal Photoautotrophic Growth Of Synechocystis Sp. Strain Pcc 6803 Under Continuous Light But Not Under A Diurnal Light Regimen, Terry M. Bricker, Shulu Zhang, Susan M. Laborde, Paul R. Mayer, Laurie K. Frankel, James V. Moroney Dec 2004

The Malic Enzyme Is Required For Optimal Photoautotrophic Growth Of Synechocystis Sp. Strain Pcc 6803 Under Continuous Light But Not Under A Diurnal Light Regimen, Terry M. Bricker, Shulu Zhang, Susan M. Laborde, Paul R. Mayer, Laurie K. Frankel, James V. Moroney

Faculty Publications

A mutation was recovered in the slr0721 gene, which encodes the decarboxylating NADP+-dependent malic enzyme in the cyanobacterium Synechocystis sp. strain PCC 6803, yielding the mutant 3WEZ. Under continuous light, 3WEZ exhibits poor photoautotrophic growth while growing photoheterotrophically on glucose at rates nearly indistinguishable from wild-type rates. Interestingly, under diurnal light conditions (12 h of light and 12 h of dark), normal photoautotrophic growth of the mutant is completely restored.

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