Digital Commons Network^™

Volatile Profiling Reveals Intracellular Metabolic Changes In Aspergillus Parasticus: Vea Regulates Branched Chain Amino Acid And Ethanol Metabolism, Ludmila V. Roze, Anindya Chanda, Maris Laivenieks, Randolph M. Beaudry, Katherine A. Artymovich, Anna V. Koptina, Deena W. Awad, Dina Valeeva, Arthur D. Jones, John E. Linz

Faculty Publications

Background: Filamentous fungi in the genus Aspergillus produce a variety of natural products, including aflatoxin, the most potent naturally occurring carcinogen known. Aflatoxin biosynthesis, one of the most highly characterized secondary metabolic pathways, offers a model system to study secondary metabolism in eukaryotes. To control or customize biosynthesis of natural products we must understand how secondary metabolism integrates into the overall cellular metabolic network. By applying a metabolomics approach we analyzed volatile compounds synthesized by Aspergillus parasiticus in an attempt to define the association of secondary metabolism with other metabolic and cellular processes.

Results: Volatile compounds were examined using solid …

A Novel Far-Field Nanoscopic Velocimetry For Nanofluidics, C. Kuang, Guiren Wang

Faculty Publications

For the first time we have been able to measure the flow velocity profile for nanofluidics with a spatial resolution better than 70 nm. Due to the diffraction resolution barrier, traditional optical methods have so far failed in measuring the velocity profile in a nanocapillary or a closed nanochannel without an opened sidewall. A novel optical point measurement method is presented which applies stimulated emission depletion (STED) microscopy to laser induced fluorescence photobleaching anemometer (LIFPA) techniques to measure flow velocity. Herein we demonstrate this far-field nanoscopic velocimetry method by measuring the velocity profile in a nanocapillary with an inner diameter …

Modeling The Noble Metal/Tio2 (110) Interface With Hybrid Dft Functionals: A Periodic Electrostatic Embedded Cluster Model Study, Salai Cheettu Ammal, Andreas Heyden

Faculty Publications

The interaction of Aun and Ptn (n=2,3) clusters with the stoichiometric and partially reduced rutile TiO2 (110) surfaces has been investigated using periodic slab and periodic electrostatic embedded cluster models. Compared to Au clusters, Pt clusters interact strongly with both stoichiometric and reduced TiO2 (110) surfaces and are able to enhance the reducibility of the TiO2 (110) surface, i.e., reduce the oxygen vacancy formation energy. The focus of this study is the effect of Hartree–Fock exchange on the description of the strength of chemical bonds at the interface of Au/Pt clusters and the TiO2 (110) surface. Hartree–Fock exchange helps describing …

Genome3d: A Viewer-Model Framework For Integrating And Visualizing Multi-Scale Epigenomic Information Within A Three-Dimensional Genome, Thomas M. Asbury, Matt Mitman, Jijun Tang, W. Jim Zheng

Faculty Publications

Background
New technologies are enabling the measurement of many types of genomic and epigenomic information at scales ranging from the atomic to nuclear. Much of this new data is increasingly structural in nature, and is often difficult to coordinate with other data sets. There is a legitimate need for integrating and visualizing these disparate data sets to reveal structural relationships not apparent when looking at these data in isolation.

Results
We have applied object-oriented technology to develop a downloadable visualization tool, Genome3D, for integrating and displaying epigenomic data within a prescribed three-dimensional physical model of the human genome. In order …

Does Genesis Really Teach A Recent, Literal, Seven-Day Creation Week And A Global Flood?, Richard M. Davidson

Faculty Publications

No abstract provided.

The Impact Of Direct And Indirect Experiences On The Development Of Environmental Knowledge, Attitudes, And Behavior, Mat D. Duerden, Peter A. Witt

Faculty Publications

This study employed a mixed-methods design to examine the relationship between nature experience type (e.g., direct and indirect) and learning outcomes (e.g., environmental knowledge, attitudes, and behavior) associated with an environmental education, international immersion program for adolescents. Longitudinal data from 108 participant and 49 comparison group members were analyzed to test the study’s hypotheses. Additionally, qualitative data were analyzed using grounded theory methodology to assess participants’ perceptions of these processes. The findings indicate that environmental knowledge increased more than environmental attitudes during the indirect portion of the program (i.e., preparatory program) whereas the direct portion (i.e., international workshop) produced similar …

Traditional Knowlege: Is Perpetual Protection A Good Idea?, J. Janewa Oseitutu

Faculty Publications

Most of the international dialogue about traditional knowledge has taken place within the context of an intellectual property framework with the World Intellectual Property Organization (WIPO) as the primary facilitator of the discussion. Following more than a decade of dialogue, the WIPO Intergovernmental Committee on Intellectual Property and Genetic Resources, Traditional Knowledge and Folklore (WIPO IGC) has been given until the Fall of 2011 to come up with something concrete. Due to the intersection between traditional knowledge and intellectual property, the resulting text is likely to be a significant development for international intellectual property law.

Developing countries have long advocated …

Perspectives Of Fitness And Health In College Men And Women, Jennifer J. Waldron, Rodney B. Dieser

Faculty Publications

Because many college students engage in low levels of physical activity, the current study used a qualitative framework to interview 11 college students to examine the meaning physically active college students assign to the practice of fitness and health. Students discussed the importance of healthy eating, but that it was difficult to accomplish at college. Additionally, students intertwined health and fitness with physical appearance and attractiveness. In particular, the media shaped many of their perceptions of health and fitness. Implications of these findings to policy making in higher education, in particular wellness programming, are highlighted.

Judicial Erasure Of Mixed-Race Discrimination, Nancy Leong

Faculty Publications

No abstract provided.

Investigating The Presuppositional Realm Of Biblical-Theological Methodology: Part 4: Critique And Transformation, Oliver Glanz

Faculty Publications

No abstract provided.

Protecting The Innocent: Part Of The Solution For Inadequate Funding For Defenders, Not A Panacea For Targeting Justice, Robert P. Mosteller

Faculty Publications

No abstract provided.

Why Defense Attorneys Cannot, But Do, Care About Innocence, Robert P. Mosteller

Faculty Publications

No abstract provided.

Introducing Stem Majors To The Teaching Profession Through Authentic Experiences As Tutors, Grinell Smith

Faculty Publications

Recruiting people with rich backgrounds in science, technology, engineering, and mathematics (STEM) into the teaching profession has historically been difficult and remains so today. In this bounded instrumental case study, undergraduate STEM majors were trained and placed as science and math tutors in grades 9-12, with an overarching goal of encouraging them to consider teaching as a possible career path. Several themes emerged from the tutors’ experiences as significant in their willingness to consider a career in teaching, including altruism from helping others, satisfaction from tutees’ improved academic performance, and a more nuanced understanding of the complex nature of teaching.

Computational Fluctuating Fluid Dynamics, Alejandro Garcia, J. B. Bell, S. Williams

Faculty Publications

This paper describes the extension of a recently developed numerical solver for the Landau-Lifshitz Navier-Stokes (LLNS) equations to binary mixtures in three dimensions. The LLNS equations incorporate thermal fluctuations into macroscopic hydrodynamics by using white-noise fluxes. These stochastic PDEs are more complicated in three dimensions due to the tensorial form of the correlations for the stochastic fluxes and in mixtures due to couplings of energy and concentration fluxes (e.g., Soret effect). We present various numerical tests of systems in and out of equilibrium, including time-dependent systems, and demonstrate good agreement with theoretical results and molecular simulation

Understanding Gender-Based Violence: Evidence From Kilimanjaro Assessment Of Rombo And Moshi Rural, Jane L. Saffitz

Faculty Publications

No abstract provided.

Measures Of Journal Quality Should Separate Reviews From Original Research, Sarah R. Supp, Ethan P. White

Faculty Publications

No abstract provided.

Distribution Of Tadpoles Of Ollotis Occidentalis (Amphibia: Anura: Bufonidae) Along The Rio Salado, Puebla, Mexico, G. A. Woolrich-Pina, Geoffrey R. Smith, L. Oliver-Lopez, M. Barbosa Morales, J. A. Lemos-Espinal

Faculty Publications

No abstract provided.

Evaluation Of The Rate Of Artificial Coverboard Use By The Salamander, Plethodon Cinereus, In The Vicinity Of Natural Cover Objects, K. Ciul, L. Simpson, Geoffrey R. Smith, Jessica E. Rettig

Faculty Publications

No abstract provided.

Contributions Of Family Leisure To Family Functioning Among Single-Parent Families, Laurel B. Hornberger, Ramon Zabriskie, Patti Freeman

Faculty Publications

The purpose of this study was to examine the contribution of family leisure involvement to the family functioning of single-parent families and to compare family functioning and family leisure between large samples of dual and single-parent families. Data were collected from a dependent child and custodial parent in 362 U.S. single-parent households. Core and balance family leisure involvement were related to both family cohesion and family adaptability, with core family leisure explaining more variance in family functioning variables from parent, youth, and family perspectives. Family functioning among single-parent families was similar to that of dual-parent families. Family leisure involvement among …

The Social-Obligation Norm Of Property: Duguit, Hayem, And Others, M C. Mirow

Faculty Publications

This article discusses and analyzes the sources and methods used by Leon Duguit in constructing the social-obligation or social-function norm of property as set out in an influential series of lectures in Buenos Aires published in 1912. The work of Henri Hayem has been underappreciated in the development of Duguit's ideas. Hayem should be restored as a central influence on Duguit's thought and as one of the main and earliest proponents of the idea of the social-function norm. The article also examines the influence of Charmont, Comte, Durkheim, Gide, Hauriou, Landry, and Saleilles in Duguit's thought on property and its …

Recovery Of An Endangered Provision: Untangling And Reviving Critical Habitat Under The Endangered Species Act, Kalyani Robbins

Faculty Publications

There has been long-term confusion among courts, agencies, developers, and environmental organizations regarding the legal, environmental, and economic impacts of designating critical habitat for species listed as threatened or endangered under the ESA. At the heart of this difficulty has been a need to understand the degree to which the protections for critical habitat can be distinguished from those for listed species generally. Critical habitat is primarily protected via section 7’s requirement that federal agencies consult with the Fish & Wildlife Service and the National Marine Fisheries Service to determine whether a proposed federal action either jeopardizes a listed species …

C.S.I. Bulls#!T: The National Academy Of Sciences, Melendedez-Diaz V. Massachusetts, And Future Challenges To Forensic Science And Forensic Evidence,, Joelle A. Moreno

Faculty Publications

No abstract provided.

"My Kids And Wife Have Been My Life": Married African American Fathers Staying The Course, Loren Marks, Katrina Hopkins-Williams, Cassandra Chaney, Olena Nesteruk, Diane Sasser

Faculty Publications

On the opening page of a recent edited volume titled Black Fathers in Contemporary American Society, Blankenhorn and Clayton (2003:1) ask, "Is any demographic fact more disturbing, more demanding of our collective attention, than the fact that the great majority of African American children do not live with their fathers?" However, they hasten to add some good news as well. The same page reads, conversely: "Is any demographic fact more hopeful, or more demanding of our collective encouragement, than the fact the proportion of African American children living with both of their biological, married parents, although still quite low, …

Socially Induced Synchronization Of Every-Other-Day Egg Laying In A Seabird Colony, Shandelle M. Henson, James L. Hayward, J. M. Cushing, Joseph C. Galusha

Faculty Publications

Spontaneous oscillator synchrony has been documented in a wide variety of electrical, mechanical, chemical, and biological systems, including the menstrual cycles of women and estrous cycles of Norway Rats (Rattus norvegicus). In temperate regions, many colonial birds breed seasonally in a time window set by photoperiod; some studies have suggested that heightened social stimulation in denser colonies can lead to a tightened annual reproductive pulse. It has been unknown, however, whether the analog of menstrual synchrony occurs in birdsthat is, whether avian ovulation cycles can synchronize on a daily timescale within the annual breeding pulse. We report every-other-day clutch-initiation and …

Design Dna Sequencing: A Set Of Methodological Artifacts For Sequencing Socio-Technical Design Routines, James Gaskin, Kalle Lyytinen, Veeresh Thummadi, Douglas Schutz, Youngjin Yoo, Aaron Weiss, Nicholas Berente

Faculty Publications

With the introduction of new digital and physical tools into the workplace, the process of design has dramatically changed over the past few decades. Thus, design processes have evolved into many forms which vary, not only between organizations, but within organizations, and even within teams over time. These myriad “mutations” of the design process call for a new method to identify patterns of design activity and their change in order to deeply understand the design process. In this paper we suggest a new method for identifying patterns of activity in design teams. Such activity involves composites of distributed interactions – …

Effects Of Early-Life Stress On 5-Ht1a Receptors In Juvenile Rhesus Monkeys Measured By Pet, Simona Spinelli, Svetlana Chefer, Richard E. Carson, Elaine Jagoda, Lixin Lang, Markus Heilig, Christina S. Barr, Stephen J. Suomi, J. Dee Higley, Elliot A. Stein

Faculty Publications

Background—Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin1A receptor (5-HT1AR) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders.

Methods—To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emission tomography (PET) to measure in vivo 5- HT1AR density and apparent dissociation constant (KD app) in the brain of juvenile rhesus monkeys exposed to the early-life stress of peer-rearing.

Results—In general, 5-HT1AR density and KD app were decreased in peer-reared …

Empathy And Error Processing, Scott A. Baldwin, Michael J. Larson, Joseph E. Fair, Daniel A. Good

Faculty Publications

Recent research suggests a relationship between empathy and error processing. Error processing is an evaluativecontrol function that can be measured using post-error response time slowing and the error-related negativity (ERN)and post-error positivity (Pe) components of the event-related potential (ERP). Thirty healthy participants completedtwo measures of empathy, the Interpersonal Reactivity Index (IRI) and the Empathy Quotient (EQ), and a modifiedStroop task. Post-error slowing was associated with increased empathic personal distress on the IRI. ERN amplitudewas related to overall empathy score on the EQ and the fantasy subscale of the IRI. The Pe and measures of empathywere not related. Results remained consistent …

Contemporary Contradictions And Challenges Facing Married Fathers And Mothers, Erin K. Holmes, Jennifer Baumgartner, Loren Marks, Rob Palkovitz, Olena Nesteruk

Faculty Publications

Part one of this review chapter provides a brief historical overview of the fathering role. Following this overview, some cultural contradictions and challenges facing fathers, particularly married fathers, are outlined and discussed. Key issues of focus in this section include married fathers balancing economic provision, household work, and involvement in child rearing. Part two of the chapter will overview cultural challenges and contradictions facing mothers, particularly married mothers. The contradictory challenges often inherent in marriage-based mothering include the pressures too simultaneously provide "intensive mothering" and to be extensively involved in a career. In sum, the chapter will illustrate how married …

The Relationship Among Couple Relationship Quality, Physical Functioning, And Depression In Multiple Sclerosis Patients And Partners, Justin K. Mcpheters, Jonathan G. Sandberg

Faculty Publications

Using Engel's biopsychosocial model and family systems theory, this study explored the associations between multiple sclerosis (MS) patient and partner reports of physical functioning, depression, and could relationship quality. Fifty-four couples recruited from the MS society completed self-reported questionnaires about couple relationship quality, demographic data, and physical functioning. In regression analyses, couple relationship quality positively related to MS patient physical functioning and depression negatively related to MS patient physical functioning. Both MS patient and partner reports of couple relationship quality negatively related to depression scores in partners. While MS patient reports of couple relationship quality negatively related to MS patient …

Experimental Measurements During Combustion Of Moist Individual Foliage Samples, Brent M. Pickett, Carl Isackson, Rebecca Wunder, Thomas H. Fletcher, Bret Buitler, David R. Weise

Faculty Publications

Individual samples of high moisture fuels from the western and southern United States and humidified aspen excelsior were burned over a flat-flame burner at 987◦ ±12 C and 10±0.5 mol% O2. Time-dependent mass and temperature profiles of these samples were obtained and analysed. It was observed that significant amounts of moisture remained in the individual samples after ignition occurred. Temperature histories showed a plateau at 200◦–300 C at the leaf perimeter rather than at 100 C, with a plateau of 140 C for the leaf interior. Implications are that classical combustion models should be altered to reflect the behaviour of …