Digital Commons Network^™

Evaluating Muscle Mass In Survivors Of Ards: A 1-Year Multicenter Longitudinal Study, Kitty S. Chan Phd, Marina Mourtzakis Phd, Lisa Aronson Friedman Scm, Victor D. Dinglas Mph, Catherine L. Hough Md, Msc, E. Wesley Ely Md, Mph, Peter E. Morris Md, Ramona O. Hopkins Phd, Dale M. Needham Fcpa, Md, Phd, National Institutes Of Health Nhlbi Ards Network

Faculty Publications

Objective—Rapid muscle wasting occurs during acute respiratory failure, resulting in muscle weakness and functional impairments. This study examines survivors’ body composition in the year after acute respiratory distress syndrome (ARDS) and tests associations of patient characteristics, hospital exposures, and survivors’ strength and physical functioning with whole body percent lean mass.

Design—Prospective cohort study with 6- and 12-month follow-up

Setting—National study enrolling patients from 5 study centers

Patients—ARDS survivors (N=120)

Interventions—None Measurements and

Main Results—Lean and fat mass from dual energy X-ray absorptiometry (DXA). On average, survivors gained whole body total mass (+1.4kg, 0.1, 2.7) and fat mass (+1.2 kg, 0.2, …

Differences In Falls And Recovery From A Slip Based On An Individual's Lower Extremity Corrective Response, Samuel J. Wilson, Paul T. Donahue, Charles C. Williams, Christopher M. Hill, Jeffrey D. Simpson, Dwight E. Waddell, Jeremy P. Loenneke, Harish Chander, Chip Wade, John C. Garner

Faculty Publications

Background: Slips and falls account for high rates of injury and mortality in multiple populations. The corrective responses during the slip perturbation have been well documented. However, when a fall results from a slip, it is unclear which of these responses were inadequate.

Objective: The purpose of this study was to examine differences in lower extremity corrective responses of the slip recovery response between individuals who fall and those who recover.

Methodology: Sixty-four participants completed this study (32 males & 32 females). Participant’s gait kinematics and kinetics were collected during normal gait (NG) and an unexpected slip …

Let It Rest: Sleep And Health As Positive Correlates Of Forgiveness Of Others And Self-Forgiveness, Loren Toussaint, Andrew J. Gall, Alyssa Cheadle, David R. Williams

Faculty Publications

Objective: The present study examined forgiveness of others, self-forgiveness, sleep, and health in a nationally representative sample of United States adults. It was hypothesised that sleep would mediate the associations of forgiveness of others and self-forgiveness with health.

Design: A nationally representative survey of 1,423 United States adults.

Main Outcome Measures: Measures included forgiveness of others, self-forgiveness, sleep quantity, sleep quality, psychological distress, life satisfaction, and self-rated physical health.

Results: Forgiveness of others (β = .20, p < .001) and self-forgiveness (β = .11, p < .01) were associated with sleep and forgiveness of others (β = .24, p < .001) and self-forgiveness (β = .27, p < .001) were associated with health. Sleep was associated with health (β = .45, p < .001) and also acted as a mediator of the associations of forgiveness of others (β = .09, p < .01) and self-forgiveness (β = .05, p < .01) with health.

Conclusions: Forgiveness of others and self-forgiveness may attenuate emotions such as anger, regret, and rumination and provide …

Equine Arteritis Virus Long-Term Persistence Is Orchestrated By Cd8+ T Lymphocyte Transcription Factors, Inhibitory Receptors, And The Cxcl16/Cxcr6 Axis, Mariano Carossino, Nikolaus Osterrieder, Pouya Dini, Theodore S. Kalbfleisch, Alan T. Loynachan, Igor F. Canisso, R. Frank Cook, Peter J. Timoney, Udeni B. R. Balasuriya

Faculty Publications

No abstract provided.

Lsu Computational System Biology Gateway For Education, Eroma Abeysinghe, Michal Brylinski, Marcus Christie, Suresh Marru, Marlon Pierce

Faculty Publications

Science gateways are a mechanism for delivering scientific software as a service, especially when the software requires high performance computing (HPC) resources to run effectively. The existence of a science gateway eliminates the user’s need to learn to work with HPC systems and to manage software installations and updates. With well-designed user interfaces, users can more quickly become effective users of scientific applications and can manage information needed for replicating, modifying, and sharing results. All of these efficiency gains enable users to focus more on their research. In addition, science gateways are being identified as an effective educational tool, a …

Two New Species Of Shrew-Rats (Rhynchomys: Muridae: Rodentia) From Luzon Island, Philippines, Eric A. Rickart, Danilo S. Balete, Robert M. Timm, Phillip A. Alviola, Jacob A. Esselstyn, Lawrence R. Heaney

Faculty Publications

The murine genus Rhynchomys includes the large-bodied Philippine "shrew-rats," highly specialized members of the vermivorous clade of Philippine murids. Four species are recognized, all of which are endemic to Luzon Island: R. soricoides from mountains within the Central Cordillera, R. isarogensis from Mt. Isarog on the Bicol Peninsula, R. banahao from Mt. Banahaw in south-central Luzon, and R. tapulao from Mt. Tapulao in the Zambales Mountains. Field surveys in 2006 and 2008 revealed two additional populations of Rhynchomys, one from Mt. Labo (1,544 m), a dormant stratovolcano at the base of the Bicol Peninsula, the other from Mt. Mingan (1,901 …

Climate Risk And Private Participation Projects In Infrastructure: Mitigating The Impact Of Locational (Dis)Advantages, Nathaniel C. Lupton, Alfredo Jiménez, Secil Bayraktar, Dimitrios Tsagdis

Faculty Publications

Purpose

The purpose of this paper is to investigate the impact of climate risk on the success vs failure of foreign direct investments (FDIs) in private participation infrastructure (PPI) projects. The authors also consider the extent to which project-level characteristics mitigate such risks.

Design/methodology/approach

The authors study a sample from the World Bank covering 18,846 projects in 111 countries from 2004 to 2013. The authors apply logistic regressions to determine the impact of climate risk and mitigating project characteristics on project failure.

Findings

The authors find that higher levels of climate risk at the host country level are associated with …

Chloride To The Rescue, Marcia E. Newcomer

Faculty Publications

© 2019 Newcomer. On the fiftieth anniversary of the discovery of the Ser-His-Asp catalytic triad, perhaps the most unusual variation on the textbook classic is described: An incomplete catalytic triad in a hydrolase is rescued by a chloride ion (Fig. 1). Structural and functional data provide compelling evidence that the active site of a phospholipase from Vibrio vulnificus employs the anion in place of the commonly observed Asp, reminding us that even well-trodden scientific ground has surprises in store.

Thermostable Lyoprotectant-Enhanced Cell-Free Protein Synthesis For On-Demand Endotoxin-Free Therapeutic Production, Kristen M. Wilding, Emily Long Zhao, Conner C. Earl, Bradley Charles Bundy

Faculty Publications

Cell-free protein synthesis has emerged as a promising platform for the production of therapeutic proteins due to its inherently open reaction environment, flexible reaction conditions and rapid protein synthesis capabilities. In recent years, lyophilized cell-free systems have widened the application space of cell-free technology by improving reagent stability outside of cold-chain storage. Current embodiments of the system, however, demonstrate poor stability at elevated temperatures. Lyoprotectants have long been recognized for the ability to preserve the activity of biological molecules during drying processes, but the application of this technology to lyophilized cell-free systems has been limited and has failed to address …

Correction To: Siah2 Modulates Sexdependent Metabolic And Inflammatory Responses In Adipose Tissue To A High-Fat Diet Challenge (Biology Of Sex Differences (2019) 10: 19 Doi: 10.1186/S13293-019-0233-Y), Sujoy Ghosh, Jessica L. Taylor, Tamra M. Mendoza, Thanh Dang, David H. Burk, Yongmei Yu, Gail Kilroy, Z. Elizabeth Floyd

Faculty Publications

© 2019 The Author(s). Following publication of the original article [1], the authors reported that Additional file 1 was incorrect. The corrected Additional file 1 is given below. Additional file Additional file 1 Related to Gene Expression Analysis. (XLSX 13 kb) .

Gender Assignment To Spanish Pseudowords By Monolingual And Basque-Spanish Bilingual Children, Rocio Pérez-Tattam, Maria José Ezeizabarrena, Hans Stadthagen-González, Virginia C. Mueller Gathercole

Faculty Publications

This study examines gender marking in the Spanish of Basque-Spanish bilingual children. We analyze data collected via a production task designed to elicit 48 DPs, controlling for gender of referents and for number and types of morphological cues to grammatical gender. The goals were to determine the extent to which participants rely on biological cues (female referent =>FEM gender, male referent =>MASC gender) and morpho-phonological cues (-a ending =>FEM, -o ending =>MASC, others =>MASC or FEM) to assign gender to pseudowords/novel words; and whether bilinguals’ language dominance (Spanish strong/weak) has an effect. Data were collected …

Agriculture, Ecosystems & Environment, William A. Arigiroff, Donald R. Zak, Rima A. Upchurch, Sydney O. Salley, A. Stuart Grandy

Faculty Publications

Fine root litter is a primary source of soil organic matter (SOM), which is a globally important pool of C that is responsive to climate change. We previously established that ~20 years of experimental nitrogen (N) deposition has slowed fine root decay and increased the storage of soil carbon (C; +18%) across a widespread northern hardwood forest ecosystem. However, the microbial mechanisms that have directly slowed fine root decay are unknown. Here, we show that experimental N deposition has decreased the relative abundance of Agaricales fungi (−31%) and increased that of partially ligninolytic Actinobacteria (+24%) on decaying fine roots. Moreover, …

A Compilation Of Global Bio-Optical In Situ Data For Ocean-Colour Satellite Applications: Version Two, André Valente, Shubha Sathyendranath, Vanda Brotas, Steve Groom, Michael Grant, Malcolm Taberner, David Antoine, Robert Arnone, William M. Balch, Kathryn Baker, Ray Barlow, Simon Bélanger, Jean-François Berthon, Şükrü Beşiktepe, Yngve Borsheim, Astrid Bracher, Vittorio Brando, Elisabetta Canuti, Francisco Chavez, Andrés Cianca, Hervé Claustre, Lesley Clementson, Richard Crout, Robert Frounin, Carlos García-Soto, Stuart W. Gibb, Richard Gould, Stanford B. Hooker, Mati Kahru, Milton Kampel, Holger Klein, Susanne Kratzer, Raphael Kudela, Jesus Ledesma, Hubert Loisel, Patricia Matrai, David Mckee, Brian G. Mitchell, Tiffany Moisan, Frank Muller-Karger, Leonie O'Dowd, Michael Ondrusek, Trevor Platt, Alex J. Poulton, Michael Repecaud, Thomas Schroeder, Timothy Smyth, Denise Smyth-Wright, Heidi M. Sosik, Michael Twardoski, Vincenzo Vellucci, Kenneth Voss, Jeremy Werdell, Marcel Wernand, Simon Wright, Giuseppe Zibordi

Faculty Publications

A global compilation of in situ data is useful to evaluate the quality of ocean-colour satellite data records. Here we describe the data compiled for the validation of the ocean-colour products from the ESA Ocean Colour Climate Change Initiative (OC-CCI). The data were acquired from several sources (including, inter alia, MOBY, BOUSSOLE, AERONET-OC, SeaBASS, NOMAD, MERMAID, AMT, ICES, HOT and GeP&CO) and span the period from 1997 to 2018. Observations of the following variables were compiled: spectral remote-sensing reflectances, concentrations of chlorophyll a, spectral inherent optical properties, spectral diffuse attenuation coefficients and total suspended matter. The data were from …

Large And Small Data Blow-Up Solutions In The Trojan Y Chromosome Model, Rana D. Parshad, Matthew Beauregard, Eric M. Takyi, Thomas Griffin, Landrey Bobo

Faculty Publications

The Trojan Y Chromosome Strategy (TYC) is an extremely well investigated biological control method for controlling invasive populations with an XX-XY sex determinism. In [35, 36] various dynamical properties of the system are analyzed, including well posedness, boundedness of solutions, and conditions for extinction or recovery. These results are derived under the assumption of positive solutions. In the current manuscript, we show that if the introduction rate of trojan fish is zero, under certain large data assumptions, negative solutions are possible for the male population, which in turn can lead to finite time blow-up in the female and male populations. …

Lignin Biopolymers In The Age Of Controlled Polymerization, Mitra S. Ganewatta, Hasala N. Lokupitiya, Chuanbing Tang

Faculty Publications

Polymers made from natural biomass are gaining interest due to the rising environmental concerns and depletion of petrochemical resources. Lignin isolated from lignocellulosic biomass is the second most abundant natural polymer next to cellulose. The paper pulp process produces industrial lignin as a byproduct that is mostly used for energy and has less significant utility in materials applications. High abundance, rich chemical functionalities, CO2 neutrality, reinforcing properties, antioxidant and UV blocking abilities, as well as environmental friendliness, make lignin an interesting substrate for materials and chemical development. However, poor processability, low reactivity, and intrinsic structural heterogeneity limit lignins′ polymeric applications …

Special Issue On The Application Of Trap And Cover Crops In Insect Pest Management, Gadi V.P. Reddy, Govinda Shrestha, Anamika Sharma

Faculty Publications

No abstract provided.

A Bayesian Adaptive Marker-Stratified Design For Molecularly Targeted Agents With Customized Hierarchical Modeling, Yong Zang, Beibei Guo, Yan Han, Sha Cao, Chi Zhang

Faculty Publications

It is well known that the treatment effect of a molecularly targeted agent (MTA) may vary dramatically, depending on each patient's biomarker profile. Therefore, for a clinical trial evaluating MTA, it is more reasonable to evaluate its treatment effect within different marker subgroups rather than evaluating the average treatment effect for the overall population. The marker-stratified design (MSD) provides a useful tool to evaluate the subgroup treatment effects of MTAs. Under the Bayesian framework, the beta-binomial model is conventionally used under the MSD to estimate the response rate and test the hypothesis. However, this conventional model ignores the fact that …

Novel Salicylic Acid Analogs Induce A Potent Defense Response In Arabidopsis, Ian Arthur Palmer, Huan Chen, Jian Chen, Ming Chang, Min Li, Fengquan Liu, Zheng Qing Fu

Faculty Publications

The master regulator of salicylic acid (SA)-mediated plant defense, NPR1 (NONEXPRESSER OF PR GENES 1) and its paralogs NPR3 and NPR4, act as SA receptors. After the perception of a pathogen, plant cells produce SA in the chloroplast. In the presence of SA, NPR1 protein is reduced from oligomers to monomers, and translocated into the nucleus. There, NPR1 binds to TGA, TCP, and WRKY transcription factors to induce expression of plant defense genes. A list of compounds structurally similar to SA was generated using ChemMine Tools and its Clustering Toolbox. Several of these analogs can induce SA-mediated defense and inhibit …

Wide-Ranging Temporal Variation In Transoceanic Movement And Population Mixing Of Bluefin Tuna In The North Atlantic Ocean, Michael A. Dance

Faculty Publications

Uncertainty regarding the movement and population exchange of Atlantic bluefin tuna (Thunnus thynnus) from the two primary spawning areas (Gulf of Mexico, Mediterranean Sea) is increasingly implicated as a major impediment for the conservation of this species. Here, two mixture methods were applied to natural chemical markers (delta O-18 and delta C-13) in otoliths (ear stones) to comprehensively investigate the nature and degree of transoceanic movement and mixing of eastern and western populations in several areas of the North Atlantic Ocean that potentially represent mixing hotspots. Areas investigated occurred on both sides of the 45 degrees W management boundary as …

Adsorption/Desorption Behavior Of Cationic And Anionic Dyes By Biochars Prepared At Normal And High Pyrolysis Temperatures, Jong Hwan Park, Jim J. Wang, Yili Meng, Zhuo Wei, Ronald D. Delaune, Dong Cheol Seo

Faculty Publications

The purpose of this study was to determine the properties of biochar prepared at higher than normal biochar production temperature and to evaluate adsorption/desorption characteristics for three commonly used dyes of different charge and molecular nature: Methylene Blue (MB), Orange G (OG) and Congo Red (CR). The switchgrass-biochar was prepared at common pyrolysis temperature of 600 °C (SB600) and higher than normal temperature of 900 °C (SB900). The results showed that the carbon content of the two biochars was similar, but most carbon in SB900 was graphitized based on FTIR and XRD observation. Dye adsorption isotherms by SB600 and SB900 …

Evaluation Of Field Of View Width In Stereo-Vision-Based Visual Homing, Damian Lyons, Benjamin Barriage, Luca Del Signore

Faculty Publications

Visual homing is a local navigation technique used to direct a robot to a previously seen location by comparing the image of the original location with the current visual image. Prior work has shown that exploiting depth cues such as image scale or stereo-depth in homing leads to improved homing performance. While it is not unusual to use a panoramic field of view (FOV) camera in visual homing, it is unusual to have a panoramic FOV stereo-camera. So, while the availability of stereo-depth information may improve performance, the concomitant-restricted FOV may be a detriment to performance, unless specialized stereo hardware …

Entomology In The 21st Century: Tackling Insect Invasions, Promoting Advancements In Technology, And Using Effective Science Communication - 2018 Student Debates, Casey Parker, Lina Bernaola, Benjamin W. Lee, Dane Elmquist, Abigail Cohen, Adrian Marshall, James Hepler, Adrian Pekarcik, Emily Justus, Kendall King, Tae Young Lee, Carlos Esquivel, Kayleigh Hauri, Christopher Mccullough, Whitney Hadden, Max Ragozzino, Morgan Roth, James Villegas, Emily Kraus, Michael Becker, Megan Mulcahy, Rui Chen, Priyanka Mittapelly, C. Scott Clem, Rachel Skinner, Tanya Josek, Daniel Pearlstein, Jonathan Tetlie, Anh Tran, Anthony Auletta, Edwin Benkert, Dylan Tussey

Faculty Publications

The 2018 student debates of the Entomological Society of America were held at the Joint Annual Meeting for the Entomological Societies of America, Canada, and British Columbia in Vancouver, BC. Three unbiased introductory speakers and six debate teams discussed and debated topics under the theme aEntomology in the 21st Century: Tackling Insect Invasions, Promoting Advancements in Technology, and Using Effective Science Communication'. This year's debate topics included: 1) What is the most harmful invasive insect species in the world? 2) How can scientists diffuse the stigma or scare factor surrounding issues that become controversial such as genetically modified organisms, agricultural …

Comparison Of Age And Growth Parameters Of Invasive Red Lionfish (Pterois Volitans) Across The Northern Gulf Of Mexico, Alexander Q. Fogg, Joseph T. Evans, Mark S. Peterson, Nancy Brown-Peterson, Eric R. Hoffmayer, G. Walter Ingram Jr.

Faculty Publications

Invasive red lionfish (Pterois volitans) have spread rapidly throughout the northern Gulf of Mexico (GOM) partly because of their high growth rate. Red lionfish were collected from the northern GOM across 3 ecological regions from 2012 through 2015. For male and female red lionfish, relationships between weight and total length (TL) were differnt by ecological region. Males acheives a greater mean weight adjusted for TL (333.6 g [standar errer (SE) 3.6]) than females (195.1 g [SE 3.7]). A subsample of 1607 pairs of sagittal otoliths (from 744 males, 716 females, and 147 fish of unknown or undetermined sex) …

Entrna: A Framework To Predict Rna Foldability, Congzhe Su, Jeffery D. Weir, Fei Zhang, Hao Yan, Teresa Wu

Faculty Publications

RNA molecules play many crucial roles in living systems. The spatial complexity that exists in RNA structures determines their cellular functions. Therefore, understanding RNA folding conformations, in particular, RNA secondary structures, is critical for elucidating biological functions. Existing literature has focused on RNA design as either an RNA structure prediction problem or an RNA inverse folding problem where free energy has played a key role.

Seven Hci Grand Challenges, Constantine Stephanidis, Gavriel Salvendy, Margherita Antona, Jessie Chen, Jianming Dong, Vincent Duffy, Xiaowen Fang, Cali Fidopiastis, Gino Fragomeni, Limin Fu, Yinni Guo, Don Harris, Andri Ioannou, Kyeong-Ah (Kate) Jeong, Shin'ichi Konomi, Heidi Kromker, Masaaki Kurosu, James Lewis, Aaron Marcus, Gabriele Meiselwitz, Abbas Moallem, Hirohiko Mori, Fiona Fui-Hoon Nah, Stavroula Ntoa, Pei-Luen Rau, Dylan Schmorrow, Keng Siau, Norbert Streitz, Wentao Wang, Sakae Yamamoto, Panayiotis Zaphiris, Jia Zhou

Faculty Publications

This article aims to investigate the Grand Challenges which arise in the current and emerging landscape of rapid technological evolution towards more intelligent interactive technologies, coupled with increased and widened societal needs, as well as individual and collective expectations that HCI, as a discipline, is called upon to address. A perspective oriented to humane and social values is adopted, formulating the challenges in terms of the impact of emerging intelligent interactive technologies on human life both at the individual and societal levels. Seven Grand Challenges are identified and presented in this article: Human-Technology Symbiosis; Human-Environment Interactions; Ethics, Privacy and Security; …

Competitive Reversal Between Plant Species Is Driven By Species‐Specific Tolerance To Flooding Stress And Nutrient Acquisition During Early Marsh Succession, Andrew Muench, Tracy Elsey‐Quirk, Zhongling Yang

Faculty Publications

No abstract provided.

Improving The Transferability Of Suspended Solid Estimation In Wetland And Deltaic Waters With An Empirical Hyperspectral Approach, Daniel Jensen, Marc Simard, Kyle Cavanaugh, Yongwei Sheng, Cédric G. Fichot, Tamlin Pavelsky, Robert Twilley

Faculty Publications

The deposition of suspended sediment is an important process that helps wetlands accrete surface material and maintain elevation in the face of sea level rise. Optical remote sensing is often employed to map total suspended solids (TSS), though algorithms typically have limited transferability in space and time due to variability in water constituent compositions, mixtures, and inherent optical properties. This study used in situ spectral reflectances and their first derivatives to compare empirical algorithms for estimating TSS using hyperspectral and multispectral data. These algorithms were applied to imagery collected by NASA’s Airborne Visible/Infrared Imaging Spectrometer-Next Generation (AVIRIS-NG) over coastal Louisiana, …

Synthesis And Characterization Of Polylactide-Pamam “Janus-Type” Linear-Dendritic Hybrids, Indika Chandrasiri, Daniel G. Abebe, Sudipta Gupta, Jon Steven Dal Williams, William D. Rieger, Briana L. Simms, Mahesh Loku Yaddehige, Ye Rim Noh, Molly E. Payne, Alexander W. Fortenberry, Adam E. Smith, Jan Ilavsky, Scott M. Grayson, Gerald J. Schneider, Davita L. Watkins

Faculty Publications

© 2019 Wiley Periodicals, Inc. Herein, we present a facile and comprehensive synthetic methodology for the preparation of polyester-polyamidoamine (PAMAM) (i.e., polyester: polylactide [PLA] (hydrophobic) and polyamidoamine, PAMAM [hydrophilic]) polymers. A library of PLA-PAMAM linear dendritic block copolymers (LDBCs) in which both l and d, l polylactide were employed in mass ratios of 30:70, 50:50, 70:30, and 90:10 (PLA:PAMAM) were synthesized and analyzed. When placed in aqueous media, the immiscibility of the hydrophilic and hydrophobic segments leads to nanophase-segregation exhibited as the formation of aggregates (e.g., vesicles, worms, and/or micelles). By employing both stereochemical configurations of PLA, the differentiation in …

Temporal And Spatial Dynamics Of Competitive Parapatry In Chewing Lice, Mark S. Hafner

Faculty Publications

We synthesize observations from 1979 to 2016 of a contact zone involving two subspecies of pocket gophers (Thomomys bottae connectens and T. b. opulentus) and their respective chewing lice (Geomydoecus aurei and G. centralis) along the Rio Grande Valley in New Mexico, U.S.A., to test predictions about the dynamics of the zone. Historically, the natural flood cycle of the Rio Grande prevented contact between the two subspecies of pocket gophers. Flood control measures completed in the 1930s permitted contact, thus establishing the hybrid zone between the pocket gophers and the contact zone between their lice (without hybridization). Since that time, …

Maternal Childhood And Lifetime Traumatic Life Events And Infant Bronchiolitis, Margaret A. Adgent, Omar Elsayed-Ali, Tebeb Gebretsadik, Frances A. Tylavsky, Mehmet Kocak, Stephania A. Cormier, Rosalind J. Wright, Kecia N. Carroll

Faculty Publications

© 2019 John Wiley & Sons Ltd Background: Viral bronchiolitis is a common respiratory infection that often affects term, otherwise healthy infants. A small literature suggests maternal stress during pregnancy is associated with bronchiolitis. However, the association between maternal exposure to lifetime traumatic stress, including traumatic events occurring in childhood or throughout the life course, and bronchiolitis has not been studied previously. Objectives: To investigate the association between maternal exposure to total lifetime and childhood traumatic stress events and infant bronchiolitis. Methods: We studied mother-infant dyads enrolled in a prospective prenatal cohort, recruited 2006-2011, and Tennessee Medicaid. During pregnancy, we …