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Thermosensitive Polymers And Thermo-Responsive Liposomal Drug Delivery Systems, Waad H. Abuwatfa, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini Feb 2022

Thermosensitive Polymers And Thermo-Responsive Liposomal Drug Delivery Systems, Waad H. Abuwatfa, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites. This paper reviews the fundamentals of thermosensitive polymers, with a particular focus on thermoresponsive liposomal-based drug delivery systems.

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Neighborhood Deprivation And Risk Of Mortality Among Men With Prostate Cancer: Findings From A Long-Term Follow-Up Study, Madhav K.C., Ariane L. Rung, Edward J. Trapido, Laura S. Rozek, Elizabeth T.H. Fontham, Jeannette T. Bensen, Laura Farnan, Susan E. Steck Phd, Mph, Rd, Lixin Song, James L. Mohler, Edward S. Peters Feb 2022

Neighborhood Deprivation And Risk Of Mortality Among Men With Prostate Cancer: Findings From A Long-Term Follow-Up Study, Madhav K.C., Ariane L. Rung, Edward J. Trapido, Laura S. Rozek, Elizabeth T.H. Fontham, Jeannette T. Bensen, Laura Farnan, Susan E. Steck Phd, Mph, Rd, Lixin Song, James L. Mohler, Edward S. Peters

Faculty Publications

Background The overall survival rate of prostate cancer (PCa) has improved over the past decades. However, huge socioeconomic and racial disparities in overall and prostate cancer-specific mortality exist. The neighborhood-level factors including socioeconomic disadvantage and lack of access to care may contribute to disparities in cancer mortality. This study examines the impact of neighborhood deprivation on mortality among PCa survivors. Methods North Carolina–Louisiana Prostate Cancer Project (PCaP) data were used. A total of 2113 men, 1046 AA and 1067 EA, with PCa were included in the analysis. Neighborhood deprivation was measured by the Area Deprivation Index (ADI) at the census …

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Fourth-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Nonlinear Systems (4th-Casam-N): I. Mathematical Framework, Dan Gabriel Cacuci Feb 2022

Fourth-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Nonlinear Systems (4th-Casam-N): I. Mathematical Framework, Dan Gabriel Cacuci

Faculty Publications

This work presents the fourth-order comprehensive sensitivity analysis methodology for nonlinear systems (abbreviated as “4th-CASAM-N”) for exactly and efficiently computing the first-, second-, third-, and fourth-order functional derivatives (customarily called “sensitivities”) of physical system responses (i.e., “system performance parameters”) to the system’s (or model) parameters. The qualifier “comprehensive” indicates that the 4th-CASAM-N methodology enables the exact and efficient computation not only of response sensitivities with respect to the customary model parameters (including computational input data, correlations, initial and/or boundary conditions) but also with respect to imprecisely known material boundaries, caused by manufacturing tolerances, of the system under consideration. The 4th-CASAM-N …

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Neural Correlates Of Inhibitory Control And Associations With Cognitive Outcomes In Bangladeshi Children Exposed To Early Adversities, Eileen F. Sullivan, Wanze Xie, Stefania Conte, John E. Richards, Talat Shama, Rashidul Haque, William A. Petri, Charles A. Nelson Feb 2022

Neural Correlates Of Inhibitory Control And Associations With Cognitive Outcomes In Bangladeshi Children Exposed To Early Adversities, Eileen F. Sullivan, Wanze Xie, Stefania Conte, John E. Richards, Talat Shama, Rashidul Haque, William A. Petri, Charles A. Nelson

Faculty Publications

There is strong support for the view that children growing up in low-income homes typically evince poorer performance on tests of inhibitory control compared to those growing up in higher income homes. Unfortunately, the vast majority of the work documenting this association has been conducted in high-income countries. It is not yet known whether the mechanisms found to mediate this association would generalize to children in low- and middle-income countries, where the risks of exposure to extreme poverty and a wide range of both biological and psychosocial hazards may be greater. We examined relations among early adversity, neural correlates of …

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The Ability Of Resveratrol To Attenuate Ovalbumin-Mediated Allergic Asthma Is Associated With Changes In Microbiota Involving The Gut-Lung Axis, Enhanced Barrier Function And Decreased Inflammation In The Lungs, Prakash Nagarkatti, Esraah Alharris, Hasan Alghetaa, Juhua Zhou, Mitzi Nagarkatti Feb 2022

The Ability Of Resveratrol To Attenuate Ovalbumin-Mediated Allergic Asthma Is Associated With Changes In Microbiota Involving The Gut-Lung Axis, Enhanced Barrier Function And Decreased Inflammation In The Lungs, Prakash Nagarkatti, Esraah Alharris, Hasan Alghetaa, Juhua Zhou, Mitzi Nagarkatti

Faculty Publications

Asthma is a chronic respiratory disease highly prevalent worldwide. Recent studies have suggested a role for microbiome-associated gut–lung axis in asthma development. In the current study, we investigated if Resveratrol (RES), a plant-based polyphenol, can attenuate ovalbumin (OVA)-induced murine allergic asthma, and if so, the role of microbiome in the gut–lung axis in this process. We found that RES attenuated allergic asthma with significant improvements in pulmonary functions in OVA-exposed mice when tested using plethysmography for frequency (F), mean volume (MV), specific airway resistance (sRaw), and delay time(dT). RES treatment also suppressed inflammatory cytokines in the lungs. RES modulated lung …

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Amorphization Of Pseudocapacitive T−Nb2O5 Accelerates Lithium Diffusivity As Revealed Using Tunable Isomorphic Architectures, Wessel Van Den Bergh, Sean Wechsler, Hasala Nadeesini Lokupitiya, Lauren Jarocha, Kwangnam Kim, James Chapman, Kyoung E. Kweon, Brandon C. Wood, Steve Heald, Morgan Stefik Phd Feb 2022

Amorphization Of Pseudocapacitive T−Nb2O5 Accelerates Lithium Diffusivity As Revealed Using Tunable Isomorphic Architectures, Wessel Van Den Bergh, Sean Wechsler, Hasala Nadeesini Lokupitiya, Lauren Jarocha, Kwangnam Kim, James Chapman, Kyoung E. Kweon, Brandon C. Wood, Steve Heald, Morgan Stefik Phd

Faculty Publications

Intercalationpseudocapacitancecan combinecapacitor-likepower densitieswith battery-likeenergy densities.Such surface-limitedbehaviorrequiresrapid diffusionwhere amorphizationcan increasesolid-statediffusivity.Here intercalationpseudoca-pacitivematerialswith tailoredextentsof amorphizationin T-Nb2O5are first reported.Amorphizationwas characterizedwithWAXS, XPS, XAFS, and EPR which suggesteda peroxide-rich(O22) surface that was consistentwith DFT predictions.A seriesof tunableisomorphicarchitecturesenabledcomparisonswhileindependentlyvaryingtransportparameters.Throughprocessof elimination,solid-statelithium diffusionwas identifiedas thedominantdiffusive-constraintdictatingthe maximumvoltagesweep rate for surface-limitedkinetics(vSLT), termed the Surface-LimitedThreshold(SLT). ThevSLTincreasedwith amorphizationhoweverstable cycling requiredcrystallineT-Nb2O5. A current-responsemodel using series-impedanceswell-matchedtheseobservations.This perspectiverevealedthat amorphizationof T-Nb2O5enhancedsolid-statediffusionby 12.2% and increasedsurface-limitationsby 17.0% (stablesamples).This approachenabledretaining95% lithiationcapacityat ~800mVs1(1,600C-rate equivalent).

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Microbial Feedbacks On Soil Organic Matter Dynamics Underlying The Legacy Effect Of Diversified Cropping Systems, Maria Mooshammer, A. Stuart Grandy, Francisco Calderon, Steve Culman, Bill Deen, Rhae A. Drijber, Kari Dunfield, Virginia L. Jin, R. Michael Lehman, Shannon L. Osborne, Marty Schmer, Timothy M. Bowles Feb 2022

Microbial Feedbacks On Soil Organic Matter Dynamics Underlying The Legacy Effect Of Diversified Cropping Systems, Maria Mooshammer, A. Stuart Grandy, Francisco Calderon, Steve Culman, Bill Deen, Rhae A. Drijber, Kari Dunfield, Virginia L. Jin, R. Michael Lehman, Shannon L. Osborne, Marty Schmer, Timothy M. Bowles

Faculty Publications

Crop rotations have well-known aboveground and belowground benefits. At regional to continental scales, the unifying mechanisms of how diversified rotations alter soil organic matter (SOM) dynamics have not been demonstrated. We assessed how increasing crop rotational diversity across a soil-climate gradient affected the integrated response of SOM chemistry, microbial community composition, and its enzymatic potential to degrade SOM. Agroecosystems with the same crop rotational diversity (all sampled during the corn phase) shared similarities in molecular SOM patterns with a strong microbial signature, pointing to common transformation processes. Differences in SOM chemistry between rotations were mainly characterized by shifts in microbial …

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Absence Of An Association Between Macular Degeneration And Young-Onset Dementia, Tung-Mei Tammy Kuang, Sudha Xirasagar Mbbs., Ph.D., Wei-Yun Lee, Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin Feb 2022

Absence Of An Association Between Macular Degeneration And Young-Onset Dementia, Tung-Mei Tammy Kuang, Sudha Xirasagar Mbbs., Ph.D., Wei-Yun Lee, Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin

Faculty Publications

A few population-based studies have reported an association between prior age-related macular degeneration and senile dementia. No study has explored a possible link between prior macular degeneration and young-onset dementia (YOD). This case–control study aimed to evaluate the association of YOD with prior macular degeneration diagnosed in the 5-year period before their index date. Data for this retrospective observational study were retrieved from Taiwan’s National Health Insurance (NHI) dataset. A total of 36,577 patients with newly diagnosed YOD from January 2010 to December 2017 were identified as the study cohort, assigning their diagnosis date as their index date. Comparison patients …

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Investigation Of Eating Disorder Risk And Body Image Dissatisfaction Among Female Competitive Cheerleaders, Allison B. Smith, Jennifer L. Gay, Eva V. Monsma, Shawn M. Arent, Mark A. Sarzynski, Dawn M. Emerson, Toni M. Torres-Mcgehee Feb 2022

Investigation Of Eating Disorder Risk And Body Image Dissatisfaction Among Female Competitive Cheerleaders, Allison B. Smith, Jennifer L. Gay, Eva V. Monsma, Shawn M. Arent, Mark A. Sarzynski, Dawn M. Emerson, Toni M. Torres-Mcgehee

Faculty Publications

Social agents associated with cheerleading environments are increasingly linked to body image dissatisfaction (BID) and eating disorders (ED). This study examined ED risk across team type, squad type, and position. An additional purpose determined BID in clothing type (daily clothing, midriff uniform, and full uniform), and meta-perceptions from the perspective of peers (MP peers), parents (MP parents), and coaches (MP coaches). Female cheerleaders ( = 268) completed an online survey which included demographics, the Eating Attitudes Test-26, and pathogenic behavior questions. Body image perceptions were assessed by using the Sex-Specific Figural Stimuli Silhouettes. Overall, 34.4% of cheerleaders ( = 268; …

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Investigation Of Eating Disorder Risk And Body Image Dissatisfaction Among Female Competitive Cheerleaders, Allison B. Smith, Jennifer L. Gay, Eva V. Monsma, Shawn M. Arent Phd, Cscs*D, Fissn, Facsm, Fnak, Mark A. Sarzynski Ph.D., Faha, Facsm, Dawn M. Emerson Ph.D., Lat, Atc, Toni Torres-Mcgehee Phd, Lat, Atc Feb 2022

Investigation Of Eating Disorder Risk And Body Image Dissatisfaction Among Female Competitive Cheerleaders, Allison B. Smith, Jennifer L. Gay, Eva V. Monsma, Shawn M. Arent Phd, Cscs*D, Fissn, Facsm, Fnak, Mark A. Sarzynski Ph.D., Faha, Facsm, Dawn M. Emerson Ph.D., Lat, Atc, Toni Torres-Mcgehee Phd, Lat, Atc

Faculty Publications

Social agents associated with cheerleading environments are increasingly linked to body image dissatisfaction (BID) and eating disorders (ED). This study examined ED risk across team type, squad type, and position. An additional purpose determined BID in clothing type (daily clothing, midriff uniform, and full uniform), and meta-perceptions from the perspective of peers (MP peers), parents (MP parents), and coaches (MP coaches). Female cheerleaders (n = 268) completed an online survey which included demographics, the Eating Attitudes Test-26, and pathogenic behavior questions. Body image perceptions were assessed by using the Sex-Specific Figural Stimuli Silhouettes. Overall, 34.4% of cheerleaders (n …

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Does A School Snack Make A Difference? An Evaluation Of The World Food Programme Emergency School Feeding Programme In Lebanon Among Lebanese And Syrian Refugee Children, Zeina Jamaluddine, Chaza Akik, Gloria Safadi, Sara Abou Fakher, Nehmat El-Helou, Soha Moussa, Dominique Anid, Hala Ghattas Ph.D. Feb 2022

Does A School Snack Make A Difference? An Evaluation Of The World Food Programme Emergency School Feeding Programme In Lebanon Among Lebanese And Syrian Refugee Children, Zeina Jamaluddine, Chaza Akik, Gloria Safadi, Sara Abou Fakher, Nehmat El-Helou, Soha Moussa, Dominique Anid, Hala Ghattas Ph.D.

Faculty Publications

Objective: To investigate the effects of providing a daily healthy school snack on children's nutritional, social and educational outcomes and explore stakeholders' perceptions of an emergency school feeding programme (SFP). Design: Convergence triangulation mixed-methods study design. Associations were examined between receiving the school feeding intervention and children's outcomes using multivariable regression models. Quantitative data were complemented with interviews and focus group discussions with parents and staff. Setting: In vulnerable communities in Lebanon, the World Food Programme has implemented an emergency SFP targeting Lebanese (attending morning sessions) and Syrian refugee children (attending afternoon sessions) in public schools. Participants: Children from ten …

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Recovery Strategies In Endurance Athletes, Robyn Braun-Trocchio, Austin J. Graybeal, Andreas Kreutzer, Elizabeth Warfield, Jessica Renteria, Kaitlyn Harrison, Ashlynn Williams, Kamiah Moss, Meena Shah Feb 2022

Recovery Strategies In Endurance Athletes, Robyn Braun-Trocchio, Austin J. Graybeal, Andreas Kreutzer, Elizabeth Warfield, Jessica Renteria, Kaitlyn Harrison, Ashlynn Williams, Kamiah Moss, Meena Shah

Faculty Publications

In order to achieve optimal performance, endurance athletes need to implement a variety of recovery strategies that are specific to their training and competition. Recovery is a multidimensional process involving physiological, psychological, emotional, social, and behavioral aspects. The purpose of the study was to examine current implementation, beliefs, and sources of information associated with recovery strategies in endurance athletes. Participants included 264 self-identified endurance athletes (male = 122, female = 139) across 11 different sports including placing top three overall in competition (em>n= 55) and placing in the top three in their age group or division (n = …

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Social Media: Good Or Evil?, Prosanta Chakrabarty Feb 2022

Social Media: Good Or Evil?, Prosanta Chakrabarty

Faculty Publications

No abstract provided.

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Relationship Between Oxidative Stress And Lifespan In Daphnia Pulex, Benedicth Ukhueduan, Charles Schumpert, Eunsuk Kim, Jeffry L. Dudycha, Rekha C. Patel Feb 2022

Relationship Between Oxidative Stress And Lifespan In Daphnia Pulex, Benedicth Ukhueduan, Charles Schumpert, Eunsuk Kim, Jeffry L. Dudycha, Rekha C. Patel

Faculty Publications

Macromolecular damage leading to cell, tissue and ultimately organ dysfunction is a major contributor to aging. Intracellular reactive oxygen species (ROS) resulting from normal metabolism cause most damage to macromolecules and the mitochondria play a central role in this process as they are the principle source of ROS. The relationship between naturally occurring variations in the mitochondrial (MT) genomes leading to correspondingly less or more ROS and macromolecular damage that changes the rate of aging associated organismal decline remains relatively unexplored. MT complex I, a component of the electron transport chain (ETC), is a key source of ROS and the …

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Hydrological Seasonality And Nutrient Stoichiometry Control Dissolved Organic Matter Characterization In A Headwater Stream, Siyue Li, Jiachen Luo, Y. Jun Xu, Liuqing Zhang, Chen Ye Feb 2022

Hydrological Seasonality And Nutrient Stoichiometry Control Dissolved Organic Matter Characterization In A Headwater Stream, Siyue Li, Jiachen Luo, Y. Jun Xu, Liuqing Zhang, Chen Ye

Faculty Publications

Dissolved organic matter (DOM) is a diverse and highly complex mixture of organic macromolecules, and thus plays a central role in aquatic ecosystems. However, responses of components and sources of DOM to hydrological processes and trophic levels (nutrient stoichiometric ratios) are poorly understood, particularly in monsoonal headwater streams of Asia that are vulnerable to catchment physical characteristics. In this study, the excitation - emission matrix florescence spectroscopy coupled with parallel factor analysis (EEM-PARAFAC) was used to explore the DOM characters in a headwater stream, where seasonal rainfalls and nutrient levels vary largely. The EEM-PARAFAC modelling identified one autochthonous protein-like fluorescence …

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Diet Quality And Dietary Inflammatory Index Score Among Women’S Cancer Survivors, Sibylle Kranz, Faten Hasan, Erin Kennedy, Jamie Zoellner, Kristin A. Guertin, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert, Roger Anderson, Wendy Cohn Feb 2022

Diet Quality And Dietary Inflammatory Index Score Among Women’S Cancer Survivors, Sibylle Kranz, Faten Hasan, Erin Kennedy, Jamie Zoellner, Kristin A. Guertin, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert, Roger Anderson, Wendy Cohn

Faculty Publications

The purpose of this study was to investigate Healthy Eating Index 2015 (HEI-2015) and Energy-Adjusted Dietary Inflammatory Index (E-DIITM) scores in women's cancer survivors and to examine socio-economic (SES) characteristics associated with these two diet indices. In this cross-sectional study, survivors of women's cancers completed a demographic questionnaire and up to three 24-h dietary recalls. HEI-2015 and E-DII scores were calculated from average intakes. One-way ANOVA was used to examine the association of various demographic factors on HEI-2015 and E-DII scores. Pearson Correlation was used to calculate the correlation between the two scores. The average HEI-2015 score was 55.0 +/- …

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The Number Of Tree Species On Earth, Roberto Cazzolla Gatti, Peter B. Reich, Javier G.P. Gamarra, Tom Crowther, Cang Hui, Albert Morera, Jean Francois Bastin, Sergio De-Miguel, Gert Jan Nabuurs, Jens Christian Svenning, Josep M. Serra-Diaz, Cory Merow, Brian Enquist, Maria Kamenetsky, Junho Lee, Jun Zhu, Jinyun Fang, Douglass F. Jacobs, Bryan Pijanowski, Arindam Banerjee, Robert A. Giaquinto, Giorgio Alberti, Angelica Maria Almeyda Zambrano, Esteban Alvarez-Davila, Alejandro Araujo-Murakami, Valerio Avitabile, Gerardo A. Aymard, Radomir Balazy, Chris Baraloto, Jorcely G. Barroso, Meredith L. Bastian, Philippe Birnbaum, Robert Bitariho Feb 2022

The Number Of Tree Species On Earth, Roberto Cazzolla Gatti, Peter B. Reich, Javier G.P. Gamarra, Tom Crowther, Cang Hui, Albert Morera, Jean Francois Bastin, Sergio De-Miguel, Gert Jan Nabuurs, Jens Christian Svenning, Josep M. Serra-Diaz, Cory Merow, Brian Enquist, Maria Kamenetsky, Junho Lee, Jun Zhu, Jinyun Fang, Douglass F. Jacobs, Bryan Pijanowski, Arindam Banerjee, Robert A. Giaquinto, Giorgio Alberti, Angelica Maria Almeyda Zambrano, Esteban Alvarez-Davila, Alejandro Araujo-Murakami, Valerio Avitabile, Gerardo A. Aymard, Radomir Balazy, Chris Baraloto, Jorcely G. Barroso, Meredith L. Bastian, Philippe Birnbaum, Robert Bitariho

Faculty Publications

One of the most fundamental questions in ecology is how many species inhabit the Earth. However, due to massive logistical and financial challenges and taxonomic difficulties connected to the species concept definition, the global numbers of species, including those of important and well-studied life forms such as trees, still remain largely unknown. Here, based on global ground-sourced data, we estimate the total tree species richness at global, continental, and biome levels. Our results indicate that there are ∼73,000 tree species globally, among which ∼9,000 tree species are yet to be discovered. Roughly 40% of undiscovered tree species are in South …

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Transmodel: An R Package For Linear Transformation Model With Censored Data, Jie Zhou, Jiajia Zhang Ph.D. Feb 2022

Transmodel: An R Package For Linear Transformation Model With Censored Data, Jie Zhou, Jiajia Zhang Ph.D.

Faculty Publications

Linear transformation models, including the proportional hazards model and proportional odds model, under right censoring were discussed by Chen, Jin, and Ying (2002). The asymptotic variance of the estimator they proposed has a closed form and can be obtained easily by plug-in rules, which improves the computational efficiency. We develop an R package TransModel based on Chen's approach. The detailed usage of the package is discussed, and the function is applied to the Veterans' Administration lung cancer data.

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Differential Effects Of Exercise Programs On Neuregulin 4, Body Composition And Cardiometabolic Risk Factors In Men With Obesity, Terence Moriarty, Ayoub Saeidi, Sevda R. Shishvan, Mohammad Soltani, Fatemeh Tarazi, Patricia K. Doyle-Baker, Shahnaz Shahrbanian, Shirin S. Mollabashi, Nikoo Khosravi, Ismail Laher, Kelly E. Johnson, Trishia A. Vandusseldorp Feb 2022

Differential Effects Of Exercise Programs On Neuregulin 4, Body Composition And Cardiometabolic Risk Factors In Men With Obesity, Terence Moriarty, Ayoub Saeidi, Sevda R. Shishvan, Mohammad Soltani, Fatemeh Tarazi, Patricia K. Doyle-Baker, Shahnaz Shahrbanian, Shirin S. Mollabashi, Nikoo Khosravi, Ismail Laher, Kelly E. Johnson, Trishia A. Vandusseldorp

Faculty Publications

Background: Neuregulin 4 (Nrg4) is an adipokine that is sensitive to energy expenditure and with a potential role in metabolic homeostasis and obesity. This study examined the effects of 12 weeks of three different exercise training protocols on Nrg4 levels, cardiometabolic risk factors, and body composition parameters in men with obesity. Methods: Sixty adult men with obesity (Mean ± SD; age: 27.60 ± 8.4 yrs.; height: 168.4 ± 2.6 cm; weight: 96.7 ± 7.2 kg) were randomly allocated into four equal (n = 15) groups: High- Intensity Interval Training (HIIT), Circuit Resistance Training (CRT), Moderate Intensity Continuous Training (MICT) or …

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Tale Of A Non-Interacting Additive In A Lithium-Ion Electrolyte: Effect On Ionic Speciation And Electrochemical Properties, J C. Rushing, C M. Stern, N Elgrishi, D G. Kuroda, J C. Rushing Feb 2022

Tale Of A Non-Interacting Additive In A Lithium-Ion Electrolyte: Effect On Ionic Speciation And Electrochemical Properties, J C. Rushing, C M. Stern, N Elgrishi, D G. Kuroda, J C. Rushing

Faculty Publications

New lithium electrolytes compatible with high energy density cells are critical for lithium metal battery applications, but dendrite formation associated with the use of dilute organic electrolytes complicates their realization. High-concentration electrolytes mitigate some of the issues of the electrolytes but introduce additional problems, such as low conductivity and high cost. Hence, pseudo-concentrated electrolytes, wherein a co-solvent is added to a dilute electrolyte, have been presented as a possible alternative to both dilute and concentrated electrolytes. However, the effect that the co-solvent has on the electrolyte properties at both macroscopic and microscopic levels is unknown. Here, a study of the …

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Tale Of A Non-Interacting Additive In A Lithium-Ion Electrolyte: Effect On Ionic Speciation And Electrochemical Properties, J C. Rushing, C M. Stern, N Elgrishi, D G. Kuroda, J C. Rushing Feb 2022

Tale Of A Non-Interacting Additive In A Lithium-Ion Electrolyte: Effect On Ionic Speciation And Electrochemical Properties, J C. Rushing, C M. Stern, N Elgrishi, D G. Kuroda, J C. Rushing

Faculty Publications

New lithium electrolytes compatible with high energy density cells are critical for lithium metal battery applications, but dendrite formation associated with the use of dilute organic electrolytes complicates their realization. High-concentration electrolytes mitigate some of the issues of the electrolytes but introduce additional problems, such as low conductivity and high cost. Hence, pseudo-concentrated electrolytes, wherein a co-solvent is added to a dilute electrolyte, have been presented as a possible alternative to both dilute and concentrated electrolytes. However, the effect that the co-solvent has on the electrolyte properties at both macroscopic and microscopic levels is unknown. Here, a study of the …

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Concurrent Identification And Characterization Of Protein Structure And Continuous Internal Dynamics With Redcraft, Hanin Omar, Aaron Hein, Casey A. Cole, Homayoun Valafar Feb 2022

Concurrent Identification And Characterization Of Protein Structure And Continuous Internal Dynamics With Redcraft, Hanin Omar, Aaron Hein, Casey A. Cole, Homayoun Valafar

Faculty Publications

Internal dynamics of proteins can play a critical role in the biological function of some proteins. Several well documented instances have been reported such as MBP, DHFR, hTS, DGCR8, and NSP1 of the SARS-CoV family of viruses. Despite the importance of internal dynamics of proteins, there currently are very few approaches that allow for meaningful separation of internal dynamics from structural aspects using experimental data. Here we present a computational approach named REDCRAFT that allows for concurrent characterization of protein structure and dynamics. Here, we have subjected DHFR (PDB-ID 1RX2), a 159-residue protein, to a fictitious, mixed mode model of …

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Comparison Of Human Urinary Exosomes Isolated Via Ultracentrifugation Alone Versus Ultracentrifugation Followed By Sec Column-Purification, Kun Huang, Sudha Garimella, Alyssa Clay-Gilmour, Lucia Vojtech, Bridget Armstrong, Madison Bessonny, Alexis Stamatikos Feb 2022

Comparison Of Human Urinary Exosomes Isolated Via Ultracentrifugation Alone Versus Ultracentrifugation Followed By Sec Column-Purification, Kun Huang, Sudha Garimella, Alyssa Clay-Gilmour, Lucia Vojtech, Bridget Armstrong, Madison Bessonny, Alexis Stamatikos

Faculty Publications

Chronic kidney disease is a progressive, incurable condition that involves a gradual loss of kidney function. While there are no non-invasive biomarkers available to determine whether individuals are susceptible to developing chronic kidney disease, small RNAs within urinary exosomes have recently emerged as a potential candidate to use for assessing renal function. Ultracentrifugation is the gold standard for urinary exosome isolation. However, extravesicular small RNA contamination can occur when isolating exosomes from biological fluids using ultracentrifugation, which may lead to misidentifying the presence of certain small RNA species in human urinary exosomes. Therefore, we characterized human urinary exosomal preparations isolated …

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Mass Removal Efficiencies In Water And Consequences After A River Diversion Into Coastal Wetlands: Second Thoughts, R. Eugene Turner, Erik M. Swenson, James M. Lee, Charles S. Milan Feb 2022

Mass Removal Efficiencies In Water And Consequences After A River Diversion Into Coastal Wetlands: Second Thoughts, R. Eugene Turner, Erik M. Swenson, James M. Lee, Charles S. Milan

Faculty Publications

Salinity control, nutrient additions, and sediment supply were directly or indirectly the rationale for a $220 million coastal wetland restoration project (Davis Pond River Diversion) that began in 2002. We sampled Mississippi River water going in and out of the receiving basin from 1999 to 2018 to understand why wetland loss increased after it began. There was a reduction in inorganic sediments, nitrogen (N), and phosphorus (P) concentrations within the ponding area of 77%, 39% and 34%, respectively, which is similar to that in other wetlands. But the average sediment accumulation of 0.6 mm year(-1) inadequately balances the present-day 5.6 …

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A Bayesian Phase I/Ii Biomarker-Based Design For Identifying Subgroup-Specific Optimal Dose For Immunotherapy, Beibei Guo, Yong Zang Feb 2022

A Bayesian Phase I/Ii Biomarker-Based Design For Identifying Subgroup-Specific Optimal Dose For Immunotherapy, Beibei Guo, Yong Zang

Faculty Publications

Immunotherapy is an innovative treatment that enlists the patient's immune system to battle tumors. The optimal dose for treating patients with an immunotherapeutic agent may differ according to their biomarker status. In this article, we propose a biomarker-based phase I/II dose-finding design for identifying subgroup-specific optimal dose for immunotherapy (BSOI) that jointly models the immune response, toxicity, and efficacy outcomes. We propose parsimonious yet flexible models to borrow information across different types of outcomes and subgroups. We quantify the desirability of the dose using a utility function and adopt a two-stage dose-finding algorithm to find the optimal dose for each …

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Singing Strategies Are Linked To Perch Use On Foraging Territories In Heart-Nosed Bats, Grace C. Smarsh, Ashley M. Long, Michael Smotherman Feb 2022

Singing Strategies Are Linked To Perch Use On Foraging Territories In Heart-Nosed Bats, Grace C. Smarsh, Ashley M. Long, Michael Smotherman

Faculty Publications

Acoustic communication allows animals to coordinate and optimize resource utilization in space. Cardioderma cor, the heart-nosed bat, is one of the few species of bats known to sing during nighttime foraging. Previous research found that heart-nosed bats react aggressively to song playback, supporting the territorial defense hypothesis of singing in this species. We further investigated the territorial defense hypothesis from an ecological standpoint, which predicts that singing should be associated with exclusive areas containing a resource, by tracking 14 individuals nightly during the dry seasons in Tanzania. We quantified the singing behavior of individuals at all perches used throughout the …

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Strict Lyapunov Functions And Feedback Controls For Sir Models With Quarantine And Vaccination, Hiroshi Ito, Michael Malisoff, Frederic Mazenc Feb 2022

Strict Lyapunov Functions And Feedback Controls For Sir Models With Quarantine And Vaccination, Hiroshi Ito, Michael Malisoff, Frederic Mazenc

Faculty Publications

We provide a new global strict Lyapunov function construction for a susceptible, infected, and recovered (or SIR) disease dynamics that includes quarantine of infected individuals and mass vaccination. We use the Lyapunov function to design feedback controls to asymptotically stabilize a desired endemic equilibrium, and to prove input-to-state stability for the dynamics with a suitable restriction on the disturbances. Our simulations illustrate the potential of our feedback controls to reduce peak levels of infected individuals.

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Predator-Pest Dynamics Of Arthropods Residing In Louisiana Soybean Agroecosystems, Scott T. Lee, Chaoyang Li, Jeffrey A. Davis Feb 2022

Predator-Pest Dynamics Of Arthropods Residing In Louisiana Soybean Agroecosystems, Scott T. Lee, Chaoyang Li, Jeffrey A. Davis

Faculty Publications

Over the past two decades, management practices within Louisiana soybean production have shifted. Successful application of an integrated pest management (IPM) strategy requires an understanding of how these changes have affected predator-pest dynamics. Surveys monitoring foliage-foraging arthropod populations in soybean took place across six locations within Louisiana over six years (2012–2014 and 2015–2018). Temporal associations of pest groups, defoliating and piercing-sucking, and predator groups relating to soybean phenology were observed. Additionally, soybean maturity groups (III, IV, and V) were also evaluated to delineate potential differences. Results indicated higher abundances of piercing-sucking pests compared to defoliating pests across both datasets (2012–2014 …

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Docking And Molecular Dynamic Of Microalgae Compounds As Potential Inhibitors Of Beta-Lactamase, Roberto Pestana-Nobles, Yani Aranguren-Diaz, Elwi Machado-Sierra, Juvenal Yosa, Nataly J. Galan-Freyle,, Laura X. Sepulveda-Montano, Daniel G. Kuroda, Leonardo C. Pacheco-Londono Feb 2022

Docking And Molecular Dynamic Of Microalgae Compounds As Potential Inhibitors Of Beta-Lactamase, Roberto Pestana-Nobles, Yani Aranguren-Diaz, Elwi Machado-Sierra, Juvenal Yosa, Nataly J. Galan-Freyle,, Laura X. Sepulveda-Montano, Daniel G. Kuroda, Leonardo C. Pacheco-Londono

Faculty Publications

Bacterial resistance is responsible for a wide variety of health problems, both in children and adults. The persistence of symptoms and infections are mainly treated with beta-lactam antibiotics. The increasing resistance to those antibiotics by bacterial pathogens generated the emergence of extended-spectrum beta-lactamases (ESBLs), an actual public health problem. This is due to rapid mutations of bacteria when exposed to antibiotics. In this case, beta-lactamases are enzymes used by bacteria to hydrolyze the beta-lactam rings present in the antibiotics. Therefore, it was necessary to explore novel molecules as potential beta-lactamases inhibitors to find antibacterial compounds against infection caused by ESBLs. …

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Whole-Genome Sequencing And Rna-Seq Reveal Differences In Genetic Mechanism For Flowering Response Between Weedy Rice And Cultivated Rice, Richard S. Garcia, Sapphire Coronejo, Jonathan Concepcion, Prasanta K. Subudhi Feb 2022

Whole-Genome Sequencing And Rna-Seq Reveal Differences In Genetic Mechanism For Flowering Response Between Weedy Rice And Cultivated Rice, Richard S. Garcia, Sapphire Coronejo, Jonathan Concepcion, Prasanta K. Subudhi

Faculty Publications

Flowering is a key agronomic trait that influences adaptation and productivity. Previous studies have indicated the genetic complexity associated with the flowering response in a photoinsensitive weedy rice accession PSRR-1 despite the presence of a photosensitive allele of a key flowering gene Hd1. In this study, we used whole-genome and RNA sequencing data from both cultivated and weedy rice to add further insights. The de novo assembly of unaligned sequences predicted 225 genes, in which 45 were specific to PSRR-1, including two genes associated with flowering. Comparison of the variants in PSRR-1 with the 3K rice genome (RG) dataset identified …

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