Digital Commons Network^™

Relationship Between Diet Quality Scores And The Risk Of Frailty And Mortality In Adults Across A Wide Age Spectrum, Kulapong Jayanama, Olga Theou, Judith Godin, Leah Cahill, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert, Michael David Wirth Msph, Phd, Yong-Moon Park, Teresa T. Fung, Kenneth Rockwood

Faculty Publications

Background

Beyond intakes of total energy and individual nutrient, eating patterns may influence health, and thereby the risk of adverse outcomes. How different diet measures relate to frailty—a general measure of increased vulnerability to unfavorable health outcomes—and mortality risk, and how this might vary across the life course, is not known. We investigated the associations of five dietary indices (Nutrition Index (NI), the energy-density Dietary Inflammatory Index (E-DII™), Healthy Eating Index-2015 (HEI-2015), Mediterranean Diet Score (MDS), and Dietary Approaches to Stop Hypertension (DASH)) with frailty and mortality.

Methods

We included 15,249 participants aged ≥ 20 years from the 2007–2012 cohorts …

Examination Of Eating Disorder Risk Among University Marching Band Artists, Nancy A. Uriegas, Dawn M. Emerson, Allison B. Smith, Melani R. Kelly, Toni M. Torres-Mcgehee

Faculty Publications

BACKGROUND: Marching band artists are a physically active population, composed of approximately 27,000 people in the United States. University marching band artists face many of the same physically active demands and mental stressors as student athletes, potentially predisposing them to injury, illness, and risk for eating disorders (EDs). The purpose of this study was to examine ED risk across sex in university marching band artists, and to determine the type of risk based on the Eating Disorder Inventory-3 (EDI-3) and Eating Disorder Inventory-3 Symptom Check List (EDI-3 SC). A secondary aim examined marching band artists and pathogenic weight control behavior …

The Epigenetics Of Gametes And Early Embryos And Potential Long-Range Consequences In Livestock Species—Filling In The Picture With Epigenomic Analyses, Linkai Zhu, Sadie L. Marjani, Zongliang Jiang

Faculty Publications

The epigenome is dynamic and forged by epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA species. Increasing lines of evidence support the concept that certain acquired traits are derived from environmental exposure during early embryonic and fetal development, i.e., fetal programming, and can even be “memorized” in the germline as epigenetic information and transmitted to future generations. Advances in technology are now driving the global profiling and precise editing of germline and embryonic epigenomes, thereby improving our understanding of epigenetic regulation and inheritance. These achievements open new avenues for the development of technologies or potential …

A Pilot Study Of A Comprehensive School Physical Activity Program In Elementary Schools: Be A Champion!, Justin B. Moore, Robert Glenn Weaver Med,Phd, Beverly J. Levie, Camelia R. Sngletary, Russell L. Carson, Michael W. Beets Med, Mph, Phd, Darla M. Castelli, Aaron Beighle, Russell R. Pate Ph.D.

Faculty Publications

Objective: In the present study, we sought to determine if a comprehensive school physical activity program (CSPAP) delivered using the Be a Champion! (BAC) framework was effective in increasing moderate-to-vigorous physical activity (MVPA) and decreasing sedentary time in elementary school youth. Methods : We implemented a CSPAP in 3 elementary schools to determine its effectiveness to youth behaviors compared to 2 control schools. Youth physical activity was assessed via accelerometry in spring 2015 and spring 2016 during school hours on school days. Implementation of the BAC components and youth behavior was assessed through direct observation from fall 2015 through winter …

The Interrelationship Between Water Access, Exclusive Breastfeeding And Diarrhea In Children: A Cross-Sectional Assessment Across 19 African Countries, Paschal A. Apanga, Ann M. Weber, Lyndsey A. Darrow, Mark S. Riddle, Wei-Chen Tung, Yan Liu, Joshua V. Garn

Faculty Publications

Background Access to an improved water supply and practicing exclusive breastfeeding are essential for improving maternal and child health outcomes. However, few studies have been equipped to assess the interdependencies between access to improved water, practicing exclusive breastfeeding, and child health. The primary aim of our study was to assess whether access to an improved water supply and water-fetching were associated with mothers’ practice of exclusive breastfeeding.

Methods We analyzed data on 247090 mothers with children 5 months old or less using Multiple Indicator Cluster Surveys from 19 African countries. Multivariable logistic regression was used to estimate the relationship between …

Food Insecurity And Food Access During Covid-19 In The San Francisco Bay Area, Giselle Pignotti, Marcelle Dougan, Iris Tablas-Mejia, Adriana Telias, Ashnee Gounden

Faculty Publications

The coronavirus (COVID-19) pandemic impacted socio-economic stability and food systems in the U.S. and worldwide. To better understand food access challenges and needs of those significantly impacted by the pandemic, an online survey was distributed in the San Francisco Bay Area from August to November of 2020. A total of 726 participants completed the survey who were recruited through paid Facebook ads and community partners outreach. This report features key results from the survey regarding changes in food security rates, food access challenges, and coping strategies used during the pandemic. Some of the key findings include: 1) There was a …

Revamping Ecosystem Services Through Agroecology—The Case Of Cereals, Gomathy Sethuraman, Nurul Amalina Mohd Zain, Sumiani Yusoff, Yin Mei Ng, Niranjan Baisakh, Acga Cheng

Faculty Publications

Globally, farming systems are mostly dominated by monoculture, which has the advantage of profitability at the expense of ecological systems. Recent years have witnessed an increasing mo-mentum in global efforts to deploy sustainable agriculture practices that mimic ecological processes, with agroecology at the forefront. In addition to the ecological aspect, agroecology also encompasses economic and social aspects targeting the whole food system. Transformative agroecology has been recognized as a stepping stone to achieving several Sustainable Development Goals (SDGs), due to its great potential to build climate change-resilient farming systems while enhancing ecosystem services and reducing biodiversity loss. Nonetheless, the available …

No Evidence That Salt Water Ingestion Kills Adult Mosquitoes (Diptera: Culicidae), Donald A. Yee, Catherine Dean, Cameron Webb, Jennifer A. Henke, Gabriela Perezchica-Harvey, Gregory S. White, Ary Faraji, Joshua D. Macaluso, Rebecca Christofferson

Faculty Publications

Various products and insecticides are available that purport to reduce wild populations of adult mosquitoes. Recently, several manufacturers and general public comments on the internet have promoted devices that claim that ingestion of salt will significantly reduce populations of wild mosquitoes to near zero; there are no known scientific efficacy data that support these claims. We tested the survival of nine mosquito species of pest and public health importance across four adult diets: Water Only, Sugar Water Only (8.00%), Salt Water Only (1.03%), and Sugar + Salt Water. Species included the following: Aedes aegypti (L.), Aedes albopictus (Skuse), Aedes dorsalis …

Elaborating The Science Of Food Choice For Rapidly Changing Food Systems In Low-And Middle-Income Countries, Christine E. Blake Ph.D., Rd, Edward A. Frongillo Jr. Ph.D., Andrea M. Warren, Shilpa V. Constantinides, Krystal K. Rampalli, Shiva Bhandari

Faculty Publications

The world’s food systems and environments have been changing dramatically, concomitant with changes in overand undernutrition. We elaborate the science of food choice to better understand, analyze, and respond to relationships between changing food environments and food choice. The science of food choice is concerned with generating knowledge about causal drivers of food choice decision making processes and behavior within immediate food and social environments. Three fundamental and interconnected questions undergird this science; 1) what do people eat from the options available and accessible?; 2) how do people interact with food environments?; and 3) why do people decide to acquire, …

Validity Of The Food Insecurity Experience Scale (Fies) For Use In League Of Arab States (Las) And Characteristics Of Food Insecure Individuals By The Human Development Index (Hdi), Olfat B. Sheikomar, Wesley Dean, Hala Ghattas Ph.D., Nadine R. Sahyoun

Faculty Publications

Background

The Food Insecurity Experience Scale (FIES) is a UN FAO Voices of the Hungry (FAO-VoH) experiential metric of food insecurity (FI). It was pilot tested in some countries but not in Arab speaking ones and validated using global data. Yet, its psychometric properties may vary in the League of Arab States (LAS) due to cultural and linguistic differences.

Objectives

1) assess the validity of FIES for use in the LAS region, 2) determine the prevalence of FI, by gender, age group, and the human development index (HDI), and 3) examine sociodemographic characteristics of severe FI individuals.

Methods

To assess …

Maternal Dietary Quality, Inflammatory Potential And Childhood Adiposity: An Individual Participant Data Pooled Analysis Of Seven European Cohorts In The Alphabet Consortium, Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Mark Hanson, Keith M. Godfrey, Romy Gaillard, Liesbeth Duijts, Barbara Heude, James Hébert Scd, Fionnuala M. Mcauliffe, Cecily Kelleher, Catherine M. Phillips

Faculty Publications

Background

Mounting evidence suggests that maternal diet influences pregnancy and birth outcomes, but its contribution to the global epidemic of childhood obesity has not as yet been definitively characterized. We investigated whether maternal whole diet quality and inflammatory potential influence childhood adiposity.

Methods

We harmonized and pooled individual participant data from 16,295 mother-child pairs in seven European birth cohorts. Maternal pre-, early-, late-, and whole-pregnancy (any time during pregnancy) dietary quality and inflammatory potential assessed with the Dietary Approaches to Stop Hypertension (DASH) score and the energy-adjusted Dietary Inflammatory Index (E-DII™) score, respectively. Primary outcome was childhood overweight and obesity …

Efforts On Changing Lifestyle Behaviors May Not Be Enough To Improve Health-Related Quality Of Life Among Adolescents: A Cluster-Randomized Controlled Trial, Alexsandra Da Silva Bandeira, Michael Beets Med, Mph, Phd, Pablo Magno Da Silveira, Marcus Vinicius Veber Lopes, Valter Cordeiro Barbosa Filho, Bruno G.G. Da Costa, Kelly Samara Silva

Faculty Publications

Schools have been the main context for physical activity (PA) and sedentary behavior (SB) interventions among adolescents, but there is inconsistent evidence on whether they also improve dimensions of the health−related quality of life (HRQoL). The aim of this study was to evaluate the effects of a school-based active lifestyle intervention on dimensions of HRQoL. A secondary aim was to verify whether sex, age, and HRQoL at baseline were moderators of the intervention effect. A cluster-randomized controlled trial was conducted at three control and three intervention schools in Florianopolis, Brazil. All students from 7th to 9th grade were invited to …

A Standard Calculation Methodology For Human Doubly Labeled Water Studies, John R. Speakman, Yosuke Yamada, Hiroyuki Sagayama, Elena S.F. Berman, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Seth A. Creasy, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Cara B. Ebbeling, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi

Faculty Publications

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 >kg). Using data for 1,021 babies and infants, …

The Roles Of Identity Formation And Moral Identity In College Student Mental Health, Health-Risk Behaviors, And Psychological Well-Being, Sam A. Hardy, Stephen W. Francis, Byron L. Zamboanga, Su Yeong Kim, Spencer G. Anderson, Larry F. Forthun

Faculty Publications

Objectives: This study examined the roles of identity formation and moral identity in predicting college student mental health (anxiety and depressive symptoms), health-risk behaviors (hazardous alcohol use and sexual risk taking), and psychological well-being (self-esteem and meaning).

Method: The sample comprised 9,500 college students (aged 18–25 years, mean = 19.78, standard deviation = 1.61: 73% female; 62% European American), from 31 different universities, who completed an online self-report survey. Results: Structural equation models found that identity maturity (commitment making and identity synthesis) predicted 5 of the health outcomes (except sexual risk taking), and moral identity predicted ail of the health …

Religiousness And Levels Of Hazardous Alcohol Use: A Latent Profile Analysis, Peter J. Jankowski, Sam A. Hardy, Byron L. Zamboanga, Lindsay S. Ham, Seth J. Schwartz, Su Yeong Kim, Larry F. Forthun, Melina M. Bersamin, Roxanne A. Donovan, Susan Krauss Whitbourne, Erica A. Hurley, Miguel Ángel Cano

Faculty Publications

Prior person-centered research has consistently identified a subgroup of highly religious participants that uses significantly less alcohol when compared to the other subgroups. The construct of religious motivation is absent from existing examinations of the nuanced combinations of religiousness dimensions within persons, and alcohol expectancy valuations have yet to be included as outcome variables. Variable-centered approaches have found religious motivation and alcohol expectancy valuations to play a protective role against individuals’ hazardous alcohol use. The current study examined latent religiousness profiles and hazardous alcohol use in a large, multisite sample of ethnically diverse college students. The sample consisted of 7412 …

Urban-Rural Differences In Covid-19 Exposures And Outcomes In The South: A Preliminary Analysis Of South Carolina, Qian Huang, Sarah Jackson, Sahar Derakhshan, Logan Lee, Erika Pham, Amber Jackson, Susan L. Cutter

Faculty Publications

As the COVID-19 pandemic moved beyond the initial heavily impacted and urbanized Northeast region of the United States, hotspots of cases in other urban areas ensued across the country in early 2020. In South Carolina, the spatial and temporal patterns were different, initially concentrating in small towns within metro counties, then diffusing to centralized urban areas and rural areas. When mitigation restrictions were relaxed, hotspots reappeared in the major cities. This paper examines the county-scale spatial and temporal patterns of confirmed cases of COVID-19 for South Carolina from March 1st—September 5th, 2020. We first describe the initial diffusion of the …

Racial Disparity In Drug Disposition In The Digestive Tract, Song Gao, Edward C. Bell, Yun Zhang, Dong Liang

Faculty Publications

The major determinants of drug or, al bioavailability are absorption and metabolism in the digestive tract. Genetic variations can cause significant differences in transporter and enzyme protein expression and function. The racial distribution of selected efflux transporter (i.e., Pgp, BCRP, MRP2) and metabolism enzyme (i.e., UGT1A1, UGT1A8) single nucleotide polymorphisms (SNPs) that are highly expressed in the digestive tract are reviewed in this paper with emphasis on the allele frequency and the impact on drug absorption, metabolism, and in vivo drug exposure. Additionally, preclinical and clinical models used to study the impact of transporter/enzyme SNPs on protein expression and function …

Transepithelial Anti-Neuroblastoma Response To Kale Among Four Vegetable Juices Using In Vitro Model Co-Culture System, John Piletz, Yuhan Mao, Debarshi Roy, Bilal Qizilbash, Eurielle Nkamssi, Enleyona Weir, Jessica Graham, Mary Emmanuel, Suwaira Iqbal, Kellie Brue, Bidisha Roy Sengupta

Faculty Publications

Juicing vegetables is thought to be an anticancer treatment. Support exists for a rank order of anticancer greens (kale > dandelion > lettuce > spinach) based on degrees of bioavailability of different phytochemicals, also offset by some noxious molecules (i.e., calcium-oxalate). We developed a new in vitro transepithelial anti-neuroblastoma model system. The juices were diluted as predicted once in the small intestine. They were applied to apical Caco-2Bbe1 cells atop dividing SH-SY5Y neuroblastoma cells, and changes in transepithelial electrical resistance (TEER) and cell growth were considered with juice spectroscopies. Studied first in monoculture, kale and dandelion were the most cytostatic juices on SH-SY5Ys, …

Digital Anthropometry For Body Circumference Measurements: Toward The Development Of Universal Three-Dimensional Optical System Analysis Software, Sima Sobhiyeh, Samantha Kennedy, Alexander Dunkel, Marcelline E. Dechenaud, Jerome A. Weston, John Shepherd, Peter Wolenski, Steven B. Heymsfield

Faculty Publications

Background/Objective: Digital anthropometric (DA) assessments are increasingly being administered with three-dimensional (3D) optical devices in clinical settings that manage patients with obesity and related metabolic disorders. However, anatomic measurement sites are not standardized across manufacturers, precluding use of published reference values and pooling of data across research centers. Subjects/Methods: This study aimed to develop universal 3D analysis software by applying novel programming strategies capable of producing device-independent DA estimates that agree with conventional anthropometric (CA) measurements made at well-defined anatomic sites. A series of technical issues related to proprietary methods of 3D geometrical reconstruction and image analysis were addressed in …

Advance Quantity Meal Preparation Pilot Program Improves Home-Cooked Meal Consumption, Cooking Attitudes, And Self-Efficacy, Shannon Mendez, Jamie Kubota, Adrianne Widaman, John Gieng

Faculty Publications

Objective

To evaluate the effects of a group-based Advance Quantity Meal Preparation(AQMP) program on the consumption of home-cooked meals, cooking attitudes, and self-efficacy in healthy adults.

Methods

Participants (n = 10) in a group setting prepared healthy meals weekly consisting of 10 entrees and 5 snacks for 6 weeks. A survey assessing cooking attitudes, cooking self-efficacy, and cooking behavior and consumption at 3 time points: preprogram, postprogram (T2), and 3 months postprogram (T3).

Results

The AQMP program increased the proportion of overall home-cooked meal consumption (T2, P = 0.03), home-cooked dinner consumption (T2, P = 0.04), cooking attitudes (T3, …

Integrating Survivors Of Stroke Into Exercise‐Based Cardiac Rehabilitation Improves Endurance And Functional Strength, Elizabeth Wherley Regan Dpt, Ph.D., Reed Handlery, Jill Campbell Stewart, Joseph Lee Pearson Ms,Drph, Sarah Wilcox Phd, Stacy L. Fritz Phd, Pt

Faculty Publications

Background

Cardiac rehabilitation (CR) is a structured exercise program prevalent in the United States for people with cardiovascular disease that has been shown to increase cardiovascular endurance and improve quality of life. Despite similar cardiovascular risk factors, stroke is not among the covered diagnoses for CR. The purpose of this study was to examine the participant impact of integrating survivors of stroke into the exercise portion of an existing hospital‐based CR program through measures of physical function and other health impacts and through qualitative evaluation of participant perception.

Methods and Results

Subacute and chronic survivors of stroke were integrated into …

Anemia Management In Rural Haitian Children: A Mixed Methods Study, Marc-Aurel Martial, Kathy A. Sward, Janice M. Morse, Andrew R. Wilson, Cempaka S. Martial, Debra S. Penney, Elie Nicolas

Faculty Publications

Introduction: We examined factors influencing anemia outcomes in rural children following implementation of a prevention program. Method: Mixed methods study of children, parents, and clinicians utilized statistical modeling and content/ ethnographic analysis. Retrospective chart abstraction evaluated treatments administered and measured hemoglobin in children aged 6 to 59 months (n = 161). Prospective interviews/questionnaires examined parent (n = 51) and clinician (n = 19) perceptions. Results: Anemia prevalence decreased by 21.2%. Predictors of increased hemoglobin were clinic visit number and age at first visit. Once anemia improved, children were likely to remain improved (P = .65). Despite favorable program perceptions, stakeholders …

Linking Genes To Traits In Fungi, A. L. Romero-Olivares, Eric W. Morrison, A. Pringle, Serita D. Frey

Faculty Publications

Fungi are mediators of the nitrogen and carbon cycles in terrestrial ecosystems. Examining how nitrogen uptake and organic matter decomposition potential differs in fungi can provide insight into the underlying mechanisms driving fungal ecological processes and ecosystem functioning. In this study, we assessed the frequency of genes encoding for specific enzymes that facilitate nitrogen uptake and organic matter decomposition in 879 fungal genomes with fungal taxa grouped into trait-based categories. Our linked gene-trait data approach revealed that gene frequencies vary across and within trait-based groups and that trait-based categories differ in trait space. We present two examples of how this …

Neighborhood Characteristics And The Mental Health Of Caregivers Cohabiting With Care Recipients Diagnosed With Alzheimer’S Disease, Dana M. Alhasan, Jana A. Hirsch, Chandra L. Jackson, Margaret Chandlee Miller, Bo Cai Ph.D., Matthew C. Lohman Ph.D.

Faculty Publications

While studies have documented the influence of caregiver and care recipient factors on caregiver health, it is important to address the potential impact of neighborhood contexts. This study estimated the cross-sectional associations between neighborhood characteristics and mental health among caregivers cohabiting with Alzheimer’s disease care recipients that were experiencing severe or non-severe neuropsychiatric symptoms (NPSs) (e.g., aggression/anxiety). We obtained data collected in 2010 on caregivers and care recipients (n

While studies have documented the influence of caregiver and care recipient factors on caregiver health, it is important to address the potential impact of neighborhood contexts. This study estimated the cross-sectional …

Associations Of Maternal Dietary Inflammatory Potential And Quality With Offspring Birth Outcomes: An Individual Participant Data Pooled Analysis Of 7 European Cohorts In The Alphabet Consortium, Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Elzbieta Trafalska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Liesbeth Duijts, Barbara Heude, James R. Hébert Scd, Fionnuala M. Mcauliffe, Cecily C. Kelleher, Catherine M. Phillips

Faculty Publications

Background

Adverse birth outcomes are major causes of morbidity and mortality during childhood and associate with a higher risk of noncommunicable diseases in adult life. Maternal periconception and antenatal nutrition, mostly focusing on single nutrients or foods, has been shown to influence infant birth outcomes. However, evidence on whole diet that considers complex nutrient and food interaction is rare and conflicting. We aim to elucidate the influence of whole-diet maternal dietary inflammatory potential and quality during periconceptional and antenatal periods on birth outcomes.

Methods and findings

We harmonized and pooled individual participant data (IPD) from up to 24,861 mother–child pairs …

Program Implementation And Church Members' Health Behaviors In A Countywide Study Of The Faith, Activity, And Nutrition Program, John Bernhart Ph.D., Mph, Ches, Sarah Wilcox Phd, Ruth P. Saunders Ph.D., Brent E. Hutto Msph, Jessica Stucker

Faculty Publications

Implementation research of health programs in faith-based organizations is lacking. The Faith, Activity, and Nutrition (FAN) program helps churches improve physical activity and fruit and vegetable behaviors of members. This study examined associations between implementation of FAN intervention components and church members' physical activity, fruit and vegetable behaviors, and self-efficacy for improving these behaviors. FAN was implemented in 35 churches in a southeastern US county. After attending in-person training, led by community health advisors, church committees received 12 months of telephone-delivered technical assistance to implement FAN according to 4 components: increasing opportunities, increasing guidelines and policies, increasing pastor support, and …

Self-Assembled Thermoresponsive Nanogel From Grafted Hyaluronic Acid As A Biocompatible Delivery Platform For Curcumin With Enhanced Drug Loading And Biological Activities, Jittima Amie Luckanagul, Pahweenvaj Ratnatilaka Na Bhuket, Chawanphat Muangnoi, Pranee Rojsitthisak, Qian Wang, Pornchai Rojsitthisak

Faculty Publications

A hyaluronic acid-grafted poly(N-isopropylacrylamide) (HA-pNIPAM) was synthesized as a polymeric nanogel platform for encapsulation and delivery of hydrophobic bioactive compounds using curcumin as a model drug. As demonstrated by transmission electron microscopy and dynamic light scattering techniques, the HA-pNIPAM was simply assembled into spherical nano-sized particles with the thermoresponsive behavior. The success of curcumin aqueous solubilization was confirmed by fluorescent spectroscopy. The resulting nanogel formulation enhanced the aqueous solubility and uptake into NIH-3T3 cells of curcumin. This nanogel formulation also demonstrates cytocompatibility against NIH-3T3 cells, which deems it safe as a delivery vehicle. Moreover, the formulation has a slight skin-protection …

Neuroprotective Effects Of Asparagus Officinalis Stem Extract In Transgenic Mice Overexpressing Amyloid Precursor Protein, Zhanglong Peng, Supinder Bedi, Vivek Mann, Alamelu Sundaresan, Kohei Homma, Gregory Gaskey, Minoru Kowada, Shahid Umar, Anil D. Kulkarni, Holger K. Eltzschig, Marie Francoise Doursout

Faculty Publications

To mimic Alzheimer's disease, transgenic mice overexpressing the amyloid precursor protein (APP) were used in this study. We hypothesize that the neuroprotective effects of ETAS®50, a standardized extract of Asparagus officinalis stem produced by Amino Up Co., Ltd. (Sapporo, Japan), are linked to the inhibition of the apoptosis cascade through an enhancement of the stress-response proteins: heat shock proteins (HSPs). APP-overexpressing mice (double-transgenic APP and PS1 mouse strains with a 129s6 background), ages 6-8 weeks old, and weighing 20-24 grams were successfully bred in our laboratory. The animals were divided into 5 groups. APP-overexpressing mice and wild-type (WT) mice were …

Food Assistance Deserts In Central Florida: Identifying Service Gaps Using Spatial Analysis, Emily Curran, Amy Armenia

Faculty Publications

No abstract provided.

Review Of S. Morris (Ed.), The Critical Thinking About Sources Cookbook, Carol A. Leibiger

Faculty Publications

No abstract provided.