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A Diversity, Equity, And Inclusion Audit Of The American Families Of Faith Project: Exploring Lifespan Spiritual Development In Religiously And Racially Diverse Families, David C. Dollahite, Justin J. Hendricks, Loren D. Marks Mar 2023

A Diversity, Equity, And Inclusion Audit Of The American Families Of Faith Project: Exploring Lifespan Spiritual Development In Religiously And Racially Diverse Families, David C. Dollahite, Justin J. Hendricks, Loren D. Marks

Faculty Publications

Social science and religious studies scholars should endeavor to broaden theories, methods, and samples to be more inclusive. Therefore, we have conducted an “equity audit” of the American Families of Faith (AFF) project. We evaluated the diversity, equity, and inclusion of the AFF project’s (a) research team, (b) products, and (c) samples. We then discuss the reasoning behind the decisions that resulted in the existing strengths and limitations of the project, the fruits of this and previous evaluations (including a presentation of some narrative accounts from parents and youths across several religious-ethnic communities across the US), opportunities for growth, and …

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Large Deflection Analysis Of General Beams In Contact-Aided Compliant Mechanisms Using Chained Pseudo-Rigid-Body Model, Mohui Jin, Collin Ynchausti, Xianmin Zhang, Zhou Yang, Benliang Zhu, Larry L. Howell Mar 2023

Large Deflection Analysis Of General Beams In Contact-Aided Compliant Mechanisms Using Chained Pseudo-Rigid-Body Model, Mohui Jin, Collin Ynchausti, Xianmin Zhang, Zhou Yang, Benliang Zhu, Larry L. Howell

Faculty Publications

The nonlinear analysis and design of contact-aided compliant mechanisms (CCMs) are challenging. This paper presents a nonlinear method for analyzing the deformation of general beams that contact rigid surfaces in CCMs. The large deflection of the general beam is modeled by using the chained pseudo-rigid-body model. A geometry constraint from the contact surface is developed to constrain the beam’s deformed configuration. The contact analysis problem is formulated based on the principle of minimum potential energy and solved using an optimization algorithm. Besides, a novel technique based on the principle of work and energy is proposed calculate the reaction force/moment of …

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On The Modeling Of A Contact-Aided Cross-Axis Flexural Pivot, Pietro Bilancia, Giovanni Berselli, Spencer P. Magleby, Larry L. Howell Mar 2023

On The Modeling Of A Contact-Aided Cross-Axis Flexural Pivot, Pietro Bilancia, Giovanni Berselli, Spencer P. Magleby, Larry L. Howell

Faculty Publications

This paper reports the study of a planar Cross-Axis Flexural Pivot (CAFP) comprising an additional contact pair. The proposed device turns useful for applications requiring a revolute joint that behaves differently when deflecting clockwise/anti-clockwise. The presence of the contact pair reduces the free length of one flexures, resulting in a considerable increment of the overall joint stiffness. The pivot behaviour is investigated, for different load cases, via the ChainedBeam-Constraint Model (CBCM), namely an accurate method to be applied in large deflection problems. A framework comprising Matlab and ANSYS is developed for testing the CAFP performances in terms of rotational stiffness, …

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A Cprbm-Based Method For Large-Deflection Analysis Of Contact-Aided Compliant Mechanisms Considering Beam-To-Beam Contacts, Mohui Jin, Benliang Zhu, Jiasi Mo, Zhou Yang, Xianmin Zhang, Larry L. Howell Mar 2023

A Cprbm-Based Method For Large-Deflection Analysis Of Contact-Aided Compliant Mechanisms Considering Beam-To-Beam Contacts, Mohui Jin, Benliang Zhu, Jiasi Mo, Zhou Yang, Xianmin Zhang, Larry L. Howell

Faculty Publications

Contact-aided compliant mechanisms (CCMs) utilize contact to achieve enhanced functionality. The contact phenomenon of CCMs increases the difficulties of their analysis and design, especially when they exhibit beam-to-beam contact. Considering the particularity of CCMs analysis, which is more about the mechanisms’ deformation, this paper presents a numerical method to analyze the large deflection and stress of the CCMs considering beam-to-beam contacts. Based on our previous work on beam-to-rigid contact, the large deformation of general beams in CCMs is modeled by using the chained pseudo-rigid-body model (CPRBM). An approximation based on the geometric information of CPRBM is proposed in this paper …

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“Are These People Real?”: Designing And Playtesting An Alternative Reality, Educational Simulation, Jason K. Mcdonald, Jonathan Balzotti, Melissa Franklin, Jessica Haws, Jamin Rowan Mar 2023

“Are These People Real?”: Designing And Playtesting An Alternative Reality, Educational Simulation, Jason K. Mcdonald, Jonathan Balzotti, Melissa Franklin, Jessica Haws, Jamin Rowan

Faculty Publications

In this design case, we report our design and playtest of a form of alternative reality, educational simulation that we call a playable case study (PCS). One of the features that make our simulations unique is how they are designed to implement a principle called This Is Not a Game, or TINAG, meaning that the affordances we design into the simulation suggest to students that the experience they are having is real, in contrast to the way the artificial nature of the experience is highlighted in many computer games. In this case, we describe some challenges we encountered in designing …

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Analysis Of The Rigid Motion Of A Conical Developable Mechanism, Mckell Woodland, Michelle Hsiung, Erin L. Matheson, C Alex Safsten, Jacob Greenwood, Denise M. Halverson, Larry L. Howell Mar 2023

Analysis Of The Rigid Motion Of A Conical Developable Mechanism, Mckell Woodland, Michelle Hsiung, Erin L. Matheson, C Alex Safsten, Jacob Greenwood, Denise M. Halverson, Larry L. Howell

Faculty Publications

We demonstrate analytically that it is possible to construct a developable mechanism on a cone that has rigid motion. We solve for the paths of rigid motion and analyze the properties of this motion. In particular, we provide an analytical method for predicting the behavior of the mechanism with respect to the conical surface. Moreover, we observe that the conical developable mechanisms specified in this paper have motion paths that necessarily contain bifurcation points which lead to an unbounded array of motion paths in the parameterization plane.

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Limits Of Extramobile And Intramobile Motion Of Cylindrical Developable Mechanisms, Jared Butler, Larry L. Howell, Spencer P. Magleby, Jacob Greenwood Mar 2023

Limits Of Extramobile And Intramobile Motion Of Cylindrical Developable Mechanisms, Jared Butler, Larry L. Howell, Spencer P. Magleby, Jacob Greenwood

Faculty Publications

Mechanisms that can both deploy and provide motions to perform desired tasks offer a multifunctional advantage over traditional mechanisms. Developable mechanisms (DMs) are devices capable of conforming to a predetermined developable surface and deploying from that surface to achieve specific motions. This paper builds on the previously identified behaviors of extramobility and intramobility by introducing the terminology of extramobile and intramobile motion, which define the motion of developable mechanisms while interior and exterior to a developable surface. The limits of motion are identified using defined conditions. It is shown that the more difficult of these conditions to kinematically predict may …

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Are Denisons In A Political Bubble, Miles Williams, Paul Djupe Mar 2023

Are Denisons In A Political Bubble, Miles Williams, Paul Djupe

Faculty Publications

No abstract provided.

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Zero Torque Compliant Mechanisms Employing Pre-Buckled Beams, Pietro Bilancia, Samuel Porter Smith, Giovanni Berselli, Spencer P. Magleby, Larry L. Howell Mar 2023

Zero Torque Compliant Mechanisms Employing Pre-Buckled Beams, Pietro Bilancia, Samuel Porter Smith, Giovanni Berselli, Spencer P. Magleby, Larry L. Howell

Faculty Publications

The concept of a statically balanced mechanism with a single rotational degree of freedom is presented. The proposed device achieves static balancing by combining positive stiff- ness elements and negative stiffness elements within a nuclear domain. Two designs are discussed. The first is composed of an Archimedean spiral and two pinned-pinned pre-buckled beams. The overall mechanism is modeled via an analytical approach and the element dimensions are optimized. The optimal configuration is then tested through finite element analysis (FEA). A second approach replaces the spiral beam with elastic custom-shaped spline beams. An FEA optimization is performed to determine the shape …

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Altogether Now! Early Introduction Of Case-Based Learning For Success In Clinical Chemistry, Cristy E. Moss Mar 2023

Altogether Now! Early Introduction Of Case-Based Learning For Success In Clinical Chemistry, Cristy E. Moss

Faculty Publications

•Differentiate between active & passive learning. •Identify ways early integration of case-based learning is beneficial for the medical laboratory student. •Summarize current methods for Integration of case-based activities into routine lecture / discussion sessions with students.

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Recovery Of Aconitic Acid From Sweet Sorghum Plant Extract Using A Solvent Mixture, And Its Potential Use As A Nematicide, K. Thomas Klasson, Yunci Qi, Gillian O. Bruni, Tristan T. Watson, Bretlyn T. Pancio, Evan Terrell Mar 2023

Recovery Of Aconitic Acid From Sweet Sorghum Plant Extract Using A Solvent Mixture, And Its Potential Use As A Nematicide, K. Thomas Klasson, Yunci Qi, Gillian O. Bruni, Tristan T. Watson, Bretlyn T. Pancio, Evan Terrell

Faculty Publications

Trans-aconitic acid (TAA) is naturally present in sweet sorghum juice and syrup, and it has been promoted as a potential biocontrol agent for nematodes. Therefore, we developed a process for the extraction of aconitic acid from sweet sorghum syrup. The process economics were evaluated, and the extract was tested for its capability to suppress the motility of the nematodes Caenorhabditis elegans and Meloidogyne incognita. Aconitic acid could be efficiently extracted from sweet sorghum syrup using acetone:butanol:ethanol mixtures, and it could be recovered from this solvent with a sodium carbonate solution, with an overall extraction and recovery efficiency of 86%. The …

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Field Applications Of Zein As A Precise Nanoscale Delivery System For Methoxyfenozide, C. A.R. Bonser, C. Tamez, J. C. White, C. E. Astete, C. M. Sabliov, J. A. Davis Mar 2023

Field Applications Of Zein As A Precise Nanoscale Delivery System For Methoxyfenozide, C. A.R. Bonser, C. Tamez, J. C. White, C. E. Astete, C. M. Sabliov, J. A. Davis

Faculty Publications

When insecticides are applied in the environment, much of the product does not reach the target pest. Biopolymeric nanoparticles as nanocarriers have the potential to improve insecticide efficacy by improving absorption, coverage, and permeability while protecting the insecticide active ingredient from abiotic conditions and extending efficacy through controlled release. We conducted a series of experiments using a biopolymeric nanoparticle synthesized from zein, a biodegradable maize protein, to compare efficacy of a nanodelivered hydrophobic insect growth regulator (methoxyfenozide) against a commercial formulation. Positively charged zein nanoparticles (empty and loaded with methoxyfenozide) were compared to the formulated product, Intrepid 2F, as a …

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Factors Influencing Consumers’ Willingness-To-Try Seafood Byproducts, Silvia Murillo, Ryan Ardoin, Witoon Prinyawiwatkul Mar 2023

Factors Influencing Consumers’ Willingness-To-Try Seafood Byproducts, Silvia Murillo, Ryan Ardoin, Witoon Prinyawiwatkul

Faculty Publications

With increasing global demand for seafood, seafood byproducts (SB) utilization can contribute to a more sustainable food supply chain through waste-to-value food product development. However, consumer perceptions of SB (e.g., fish skin and bones) are underexplored. Therefore, this study aims to evaluate some factors influencing consumers’ willingness-to-try seafood byproducts. An online survey was conducted in the USA regarding intervention of SB informational cues with N = 904 adult seafood consumers internationally. The proportion of consumers willing to try SB increased significantly (McNemar’s test, α = 0.05) from 47% to 68% after SB safety and health claims had been presented in …

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A Fracture Multiscale Model For Peridynamic Enrichment Within The Partition Of Unity Method, Matthias Birner, Patrick Diehl, Robert Lipton, Marc Alexander Schweitzer Mar 2023

A Fracture Multiscale Model For Peridynamic Enrichment Within The Partition Of Unity Method, Matthias Birner, Patrick Diehl, Robert Lipton, Marc Alexander Schweitzer

Faculty Publications

Partition of unity methods are of domain decomposition type and provide the opportunity for multiscale and multiphysics numerical modeling. Different physical models can exist within a partition of unity method scheme for handling problems with zones of linear elasticity and zones where fractures occur. Here, the peridynamic model is used in regions of fracture and smooth partition of unity methods is used in the surrounding linear elastic media. Our method is novel in that we evolve the crack path using peridynamics and apply the partition of unity method to compute the elastic fields in the neighborhood of the crack tip. …

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Pseudomonas Aeruginosa Dps (Pa0962) Functions In H2o2 Mediated Oxidative Stress Defense And Exhibits In Vitro Dna Cleaving Activity, Nimesha Rajapaksha, Anabel Soldano, Huili Yao, Fabrizio Donnarumma, Maithri M. Kashipathy, Steve Seibold, Kevin P. Battaile, Scott Lovell, Mario Rivera Mar 2023

Pseudomonas Aeruginosa Dps (Pa0962) Functions In H2o2 Mediated Oxidative Stress Defense And Exhibits In Vitro Dna Cleaving Activity, Nimesha Rajapaksha, Anabel Soldano, Huili Yao, Fabrizio Donnarumma, Maithri M. Kashipathy, Steve Seibold, Kevin P. Battaile, Scott Lovell, Mario Rivera

Faculty Publications

We report the structural, biochemical, and functional characterization of the product of gene PA0962 from Pseudomonas aeruginosa PAO1. The protein, termed Pa Dps, adopts the Dps subunit fold and oligomerizes into a nearly spherical 12-mer quaternary structure at pH 6.0 or in the presence of divalent cations at neutral pH and above. The 12-Mer Pa Dps contains two di-iron centers at the interface of each subunit dimer, coordinated by conserved His, Glu, and Asp residues. In vitro, the di-iron centers catalyze the oxidation of Fe2+ utilizing H2O2 (not O2) as an oxidant, suggesting Pa Dps functions to aid P. …

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Sophisticated Vs. Rugged: Examining Gendered Brand Communication Styles And Social Media Engagement, Joanne T. Cao, Jamye Foster, Gallayanee S. Yaoyuneyong, Lacey K. Wallace Mar 2023

Sophisticated Vs. Rugged: Examining Gendered Brand Communication Styles And Social Media Engagement, Joanne T. Cao, Jamye Foster, Gallayanee S. Yaoyuneyong, Lacey K. Wallace

Faculty Publications

Advertising and marketing managers understand that not all brands need to be on social media, but what is not clearly understood is consumers’ engagement expectations for brands that are on social media. Therefore, this study investigates the impact of brand personality, specifically sophisticated and rugged brands, and gendered communication styles on consumers’ expectations of social media engagement. A scenario-based experiment is performed to test the hypotheses using a mock brand. The main study consisted of a Qualtrics consumer panel, and a MANOVA was utilized to examine three components of social media engagement (consumption, contribution, and creation) on the two brand …

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Policy Comparison Of Lead Hunting Ammunition Bans And Voluntary Nonlead Programs For California Condors, Robin M. Rotman, John H. Schulz, Samantha Totoni, Sonja A. Wilhelm Stanis, Christine Jie Li, Mark Morgan, Damon M. Hall, Elisabeth B. Webb Mar 2023

Policy Comparison Of Lead Hunting Ammunition Bans And Voluntary Nonlead Programs For California Condors, Robin M. Rotman, John H. Schulz, Samantha Totoni, Sonja A. Wilhelm Stanis, Christine Jie Li, Mark Morgan, Damon M. Hall, Elisabeth B. Webb

Faculty Publications

The endangered California condor (Gymnogyps californianus) is negatively affected by lead poisoning from spent lead‐based hunting ammunition. Because lead poisoning is the primary mortality factor affecting condors, the California Fish and Game Commission banned lead hunting ammunition during 2008 in the southern California condor range followed by a statewide ban implemented in 2019. In contrast, the Arizona Game and Fish Department instituted an outreach and awareness program encouraging voluntary use of nonlead hunting ammunition in the northern portion of the state during 2005 and a similar program was launched in Utah during 2012. The juxtaposition of policy tools provided a …

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The First Amendment And The Second Sex, Cristina Carmody Tilley Mar 2023

The First Amendment And The Second Sex, Cristina Carmody Tilley

Faculty Publications

Modern American law describes speech in stereotypically masculine terms: it is a “marketplace” where participants “joust” for dominance. Predictably, today’s speech jurisprudence can be hostile to the female voice, implicitly condoning gendered death threats, rape threats, doxing, and trolling as the necessary price of a vibrant national discourse. Unpredictably, the American Civil Liberties Union (“ACLU”) and its leading women drafted the blueprint for this modern speech edifice. The First Amendment and the Second Sex traces the ACLU campaign to dismantle a nineteenth-century speech regime that silenced some men while protecting many women. And it suggests that ACLU feminists—intent on securing …

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Ice-Crystal-Templated “Accordion-Like” Cellulose Nanofiber/Mxene Composite Aerogels For Sensitive Wearable Pressure Sensors, Wangwang Xu, Qinglin Wu, Jaegyoung Gwon, Jin Woo Choi Feb 2023

Ice-Crystal-Templated “Accordion-Like” Cellulose Nanofiber/Mxene Composite Aerogels For Sensitive Wearable Pressure Sensors, Wangwang Xu, Qinglin Wu, Jaegyoung Gwon, Jin Woo Choi

Faculty Publications

Exfoliated MXene nanosheets are integrated with cellulose nanofibers (CNFs) to form composite aerogels with high electric conductivity. The combination of CNFs and MXene nanosheets forms a unique “accordion-like” hierarchical architecture with MXene-CNF pillared layers through ice-crystal templating. Benefiting from the special “layer-strut” structure, the MXene/CNF composite aerogels have low density (50 mg/cm3), excellent compressibility and recoverability, as well as superior fatigue resistance (up to 1000 cycles). When being used as a piezoresistive sensor, the composite aerogel exhibits high sensitivity upon different strains, stable sensing performance with various compressive frequencies, broad detection range, and quick responsiveness (0.48 s). Moreover, the piezoresistive …

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Florawear: Wearable Living Interface, Hye Yeon Nam, Janiece Campbell, Andrew M. Webb, Brendan Harmon Feb 2023

Florawear: Wearable Living Interface, Hye Yeon Nam, Janiece Campbell, Andrew M. Webb, Brendan Harmon

Faculty Publications

While nature can benefit people both mentally and physically, contemporary society has become increasingly disconnected from nature. To rebuild a stronger connection with nature in our everyday life, we introduce FloraWear, a do-it-yourself, wearable living interface, that enables people to easily and closely connect with plants. This pictorial introduces how knowledge is built and shared with others using hybrid craft and fabrication, illustrates the material experiments and design development for FloraWear, and discusses how it affects wearers. Then we summarize how FloraWear can help catalyze a shift in people's perspectives towards nature. By developing emotional ties to their wearable plants, …

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Analysis And Technical Optimization Of Processing Condition For Better Quality Of Robusta Coffee Production, Usman Ahmad, Khalimatus Sa’Diyah, Sathivel Subramaniam Feb 2023

Analysis And Technical Optimization Of Processing Condition For Better Quality Of Robusta Coffee Production, Usman Ahmad, Khalimatus Sa’Diyah, Sathivel Subramaniam

Faculty Publications

The wet processing of robusta coffee starts with harvesting coffee cherries, followed by sorting the cherries, pulping, fermentation, washing, drying, hard skin hulling, bean sorting, and packaging. Soaking fruit before pulping is an alternative for coffee farmers to delay the pulping process if time does not al-low it. The fermentation process aims to remove mucus that is firmly attached to the hard skin. The addition of L. casei bacteria can accelerate the process but affect the final taste. This study aimed to optimize the duration of soaking and fermentation processes for obtaining coffee beans with a minimum number of unpeeled …

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Lies,Damn Lies, And Kamikaze Lies: Protecting Falsehoods In The Name Of Truth, Doris Deltosto Brogan Feb 2023

Lies,Damn Lies, And Kamikaze Lies: Protecting Falsehoods In The Name Of Truth, Doris Deltosto Brogan

Faculty Publications

Despite calls to reverse New York Times v. Sullivan and abandon the reckless disregard standard for public figure defamation cases--calls offered by two Supreme Court Justices, a number of legal scholars and some members of the popular press-- this article demonstrates that Sullivan’s protections have never been more relevant or more necessary, particularly in light of an epidemic of malicious, often strategic falsity, as well as overt assaults on the institutional press by powerful actors. We need Sullivan now more than ever. Further, for Sullivan to do its work effectively, it must be reinforced by two other legal protections: robust …

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How Noise Thresholds Affect The Information Content Of Stellar Flare Sequences, Elmer C. Rivera, Jay R. Johnson, Jonathan Homan, Simon Wing Feb 2023

How Noise Thresholds Affect The Information Content Of Stellar Flare Sequences, Elmer C. Rivera, Jay R. Johnson, Jonathan Homan, Simon Wing

Faculty Publications

Systems that exhibit discrete dynamics can be well described and reconstructed by considering the set of time intervals between the discrete events of the system. The Kepler satellite has cataloged light curves for many Sun-like stars, and these light curves show strong bursts in intensity that are associated with stellar flares. The waiting time between these flares describes the fundamental dynamics of the stars and is driven by physical processes, such as flux emergence. While it is rather straightforward to identify large flares, the identification of weaker flares can be challenging because of the presence of noise. A common practice …

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Enhanced Phase Sensitivity In A Mach-Zehnder Interferometer Via Photon Recycling, Dong Li, Chun Hua Yuan, Xiaoping Ma, Qingle Wang, Hwang Lee, Yao Yao, Weiping Zhang Feb 2023

Enhanced Phase Sensitivity In A Mach-Zehnder Interferometer Via Photon Recycling, Dong Li, Chun Hua Yuan, Xiaoping Ma, Qingle Wang, Hwang Lee, Yao Yao, Weiping Zhang

Faculty Publications

We propose an alternative scheme for phase estimation in a Mach-Zehnder interferometer (MZI) with photon recycling. It is demonstrated that with the same coherent-state input and homodyne detection, our proposal possesses a phase sensitivity beyond the traditional MZI. For instance, it can achieve an enhancement factor of ∼9.32 in the phase sensitivity compared with the conventional scheme even with a photon loss of 10% on the photon-recycled arm. From another point of view, the quantum Cramér-Rao bound (QCRB) is also investigated. It is found that our scheme is able to achieve a lower QCRB than the traditional one. Intriguingly, the …

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Strange Statutory Foundations And Terribly Tricky Treasures In Trust, Thomas Simmons Feb 2023

Strange Statutory Foundations And Terribly Tricky Treasures In Trust, Thomas Simmons

Faculty Publications

This paper summarizes two distinct topics: statutory foundations and a varied collection of unique and potentially troubling kinds of assets that might be held by fiduciaries such as trustees. Statutory foundations have recently been legislative approved in two states; Wyoming and New Hampshire and they represent new and interesting planning opportunities for estate planners. Tricky assets can range from the difficult-to-inventory (such as comic books and baseball cards) to outright contraband.

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Emotion Classification Of Indonesian Tweets Using Bidirectional Lstm, Aaron K. Glenn, Phillip M. Lacasse, Bruce A. Cox Feb 2023

Emotion Classification Of Indonesian Tweets Using Bidirectional Lstm, Aaron K. Glenn, Phillip M. Lacasse, Bruce A. Cox

Faculty Publications

Emotion classification can be a powerful tool to derive narratives from social media data. Traditional machine learning models that perform emotion classification on Indonesian Twitter data exist but rely on closed-source features. Recurrent neural networks can meet or exceed the performance of state-of-the-art traditional machine learning techniques using exclusively open-source data and models. Specifically, these results show that recurrent neural network variants can produce more than an 8% gain in accuracy in comparison with logistic regression and SVM techniques and a 15% gain over random forest when using FastText embeddings. This research found a statistical significance in the performance of …

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Review Of Covenant Of Water, Michael F. Russo Feb 2023

Review Of Covenant Of Water, Michael F. Russo

Faculty Publications

No abstract provided.

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Informe Tecnico De Los Trabajos De Campo Del Proyecto De Investigación Arqueológica Cerro San Isidro, Valle De Nepeña, Costa De Ancash -- Temporada 2022, David Chicoine, Jeisen Navarro Feb 2023

Informe Tecnico De Los Trabajos De Campo Del Proyecto De Investigación Arqueológica Cerro San Isidro, Valle De Nepeña, Costa De Ancash -- Temporada 2022, David Chicoine, Jeisen Navarro

Faculty Publications

No abstract provided.

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Discovery Of Novel Bioactive Tanshinones And Carnosol Analogues Against Breast Cancer, Miguel A. González-Cardenete, Natalia González-Zapata, Lucinda Boyd, Fatima Rivas Feb 2023

Discovery Of Novel Bioactive Tanshinones And Carnosol Analogues Against Breast Cancer, Miguel A. González-Cardenete, Natalia González-Zapata, Lucinda Boyd, Fatima Rivas

Faculty Publications

The abietane diterpenoids ferruginol (1), tanshinone IIA (3), and carnosol (4) are well-known for their interesting pharmacological properties, including antitumor, similar to other natural and semisynthetic abietanes. In this study, a pair of semisynthetic C18-functionalized analogues of 3 and 4 were prepared from the commercially available (+)-dehydroabietylamine or readily obtained methyl dehydroabietate. Semisynthetic ferruginol (1) and some selected analogues, together with the synthesized analogues, were tested in vitro for the inhibition of proliferation in four breast cancer cell lines, SUM149, MDA-MB231, T47D, and MCF07. As a result, several tested abietane analogues decreased cell proliferation and enhanced cell death, with IC50 …

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Inactivation Of The Ul37 Deamidase Enhances Virus Replication And Spread Of The Hsv-1(Vc2) Oncolytic Vaccine Strain And Secretion Of Gm-Csf, Carolyn M. Clark, Nithya Jambunathan, Therese M.A. Collantes, Konstantin G. Kousoulas Feb 2023

Inactivation Of The Ul37 Deamidase Enhances Virus Replication And Spread Of The Hsv-1(Vc2) Oncolytic Vaccine Strain And Secretion Of Gm-Csf, Carolyn M. Clark, Nithya Jambunathan, Therese M.A. Collantes, Konstantin G. Kousoulas

Faculty Publications

The HSV-1 (VC2) live-attenuated vaccine strain was engineered with specific deletions in the amino termini of glycoprotein K (gK) and membrane protein UL20, rendering the virus unable to enter neurons and establish latency. VC2 replicates efficiently in epithelial cell culture but produces lower viral titers and smaller viral plaques than its parental HSV-1 (F) wild-type virus. VC2 is an effective live-attenuated vaccine against HSV-1 and HSV-2 infections in mice and guinea pigs and an anti-tumor immunotherapeutic and oncolytic virus against melanoma and breast cancer in mouse models. Previously, we reported that the gK/UL20 complex interacts with the UL37 tegument protein, …

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