Digital Commons Network^™

Optimization Of Host Cell-Compatible, Antimicrobial Peptides Effective Against Biofilms And Clinical Isolates Of Drug-Resistant Bacteria, Jenisha Ghimire, Robert J. Hart, Anabel Soldano, Charles H. Chen, Shantanu Guha, Joseph P. Hoffmann, Kalen M. Hall, Leisheng Sun, Benjamin J. Nelson, Timothy K. Lu, Jay K. Kolls, Mario Rivera, Lisa A. Morici, William C. Wimley

Faculty Publications

Here, we describe the continued synthetic molecular evolution of a lineage of host-compatible antimicrobial peptides (AMP) intended for the treatment of wounds infected with drug-resistant, biofilm-forming bacteria. The peptides tested are variants of an evolved AMP called d-amino acid CONsensus with Glycine Absent (d-CONGA), which has excellent antimicrobial activities in vitro and in vivo. In this newest generation of rational d-CONGA variants, we tested multiple sequence-structure-function hypotheses that had not been tested in previous generations. Many of the peptide variants have lower antibacterial activity against Gram-positive or Gram-negative pathogens, especially variants that have altered hydrophobicity, secondary structure potential, or spatial …

Ion Selective And Water Resistant Cellulose Nanofiber/Mxene Membrane Enabled Cycling Zn Anode At High Currents, Wangwang Xu, Xiaobin Liao, Weina Xu, Kangning Zhao, Guang Yao, Qinglin Wu

Faculty Publications

Aqueous rechargeable zinc ion batteries (ZIBs) are regarded as a promising candidates for next-generation energy storage devices but strongly hindered by the limited utilization of the zinc metal anode (below 5%) due to the active water/anion corrosion. Herein, an ion selective and water-resistant cellulose nanofiber (CNF)/MXene composite membrane has been developed through molecular sieving to restrict active water and anions from the electrode/electrolyte interface through dehydration of zinc ions, avoiding the water/anion-induced corrosion/decomposition. In this way, the CNF/MXene@Zn anode exhibits significantly enhanced coulombic efficiency (99.5 % at 10 mA cm-2) and low voltage hysteresis. Moreover, coated with CNF/MXene composite membrane, …

Trauma-Informed Academic Partnership, Ingrid Weiss Slikkers

Faculty Publications

No abstract provided.

Intersectional Management: An Analysis Of Cooperation And Competition On American Public Lands, Robin M. Rotman, Abigail M. Hunt

Faculty Publications

The United States government holds public lands in trust for the whole of the American people. This article focuses on National Monuments under the Antiquities Act. It argues that the federal government should renew its approach to the management of these lands by incorporating principles of environmental justice and long- term environmental viability. The article begins by examining the historical and legal foundations of federal lands in the United States, with a focus on the Antiquities Act. It then reflects on recent litigation and political controversy surrounding Bears Ears National Monument and Grand Staircase–Escalante National Monument, to illustrate how the …

Real Mediation Systems To Help Parties And Mediators Achieve Their Goals, John M. Lande

Faculty Publications

This article argues that it is time for a paradigm shift in our current general mediation theory because of numerous problems. Our current theory is incomplete at best and seriously misleading at worst. The traditional mediation models are oversimplified, poorly mapping onto the reality of practice. They combine multiple elements that are not necessarily correlated. Many practitioners ignore them because they are confusing or not helpful. People do not understand the theoretical meanings because the terms are not consistent with commonly understood language. Arguments about what is or is not real or good mediation have spawned unhelpful ideological divisions in …

The Impact Of Covid-19, Mental Health Distress, And School-Based Sociocultural Protective Factors Among Elementary-Aged Children And Their Caregivers, Aijah K.B. Goodwin, Anthony J. Roberson, Ar’Reon Watson, Grace L. Chen, Anna C.J. Long

Faculty Publications

Given the individual and systemic stress endured by children and families during the COVID-19 pandemic, research examining culturally responsive school experiences and supports to enhance resilience is critical. This study examined the relationship between caregivers’ perceptions of COVID-19 impact, mental health distress among children and caregivers, and school-based sociocultural protective factors, including culturally responsive practices in schools and the relationships between teachers and caregivers, concurrently and longitudinally. Data were collected from caregivers of elementary-aged children at two-time points from March to April 2020 (N = 174) and one year later in 2021 (N = 114). Regression analyses revealed that COVID-19 …

Environmental Attitudes And Fertility Desires Among Us Adolescents From 2005–2019, Heather M. Rackin, Alison Gemmill, Caroline Sten Hartnett

Faculty Publications

Objective: This brief report examines links between environmental attitudes and fertility desires over time in the United States. Background: To understand fertility decision making, it is important to identify factors that influence fertility desires. Concerns about environmental problems may be associated with lower desired fertility, especially in recent cohorts transitioning to adulthood. Youth may feel that having one less child can reduce their “carbon footprint” or may be unwilling to bring children into an uncertain and difficult future due to climate change. Method: Data are from 12th graders in the Monitoring the Future study (2005–2019; N = 34,104). Regression is …

Stable Isotope Tracing Reveals An Altered Fate Of Glucose In N-Acetyltransferase 1 Knockout Breast Cancer Cells, James T.F. Wise, Xinmin Yin, Xipeng Ma, Xiang Zhang, David W. Hein

Faculty Publications

Breast cancer is one of the leading causes of cancer death. Recent studies found that arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer, further suggesting NAT1 could be a potential therapeutic target for breast cancer. Previous publications have established that NAT1 knockout (KO) in breast cancer cell lines leads to growth reduction both in vitro and in vivo and metabolic changes. These reports suggest that NAT1 contributes to the energy metabolism of breast cancer cells. Proteomic analysis and non-targeted metabolomics suggested that NAT1 KO may change the fate of glucose as it relates to the TCA/KREB cycle of …

Evaluation Of Alternative Colony Hybridization Methods For Pathogenic Vibrios, Andrew M. Schwartz, Haley A. Marcotte, Crystal N. Johnson

Faculty Publications

Vibrios, such as Vibrio parahaemolyticus, are naturally occurring halophilic bacteria that are a major cause of foodborne illness. Because of their autochthonous nature, managing vibrio levels in marine and estuarine environments is impossible. Instead, it is crucial to reliably enumerate their abundance to minimize human exposure. One method of achieving this is the direct plating/colony hybridization (DP/CH) method, which has been used to efficiently quantify pathogenic vibrios in oysters and other seafood products. Although successful, the method relies on proprietary resources. We examined alternative approaches, assessed the influence of the reagent suppliers’ source on enumeration accuracy, and made experimental adjustments …

Ecophysiology And Genomics Of The Brackish Water Adapted Sar11 Subclade Iiia, V. Celeste Lanclos, Anna N. Rasmussen, Conner Y. Kojima, Chuankai Cheng, Michael W. Henson, Brant C. Faircloth, Christopher A. Francis, J. Cameron Thrash

Faculty Publications

The Order Pelagibacterales (SAR11) is the most abundant group of heterotrophic bacterioplankton in global oceans and comprises multiple subclades with unique spatiotemporal distributions. Subclade IIIa is the primary SAR11 group in brackish waters and shares a common ancestor with the dominant freshwater IIIb (LD12) subclade. Despite its dominance in brackish environments, subclade IIIa lacks systematic genomic or ecological studies. Here, we combine closed genomes from new IIIa isolates, new IIIa MAGS from San Francisco Bay (SFB), and 460 highly complete publicly available SAR11 genomes for the most comprehensive pangenomic study of subclade IIIa to date. Subclade IIIa represents a taxonomic …

Attributes Of Culture Bacteria As Influenced By Ingredients That Help Treat Leaky Gut, Ricardo S. Aleman, David Paz, Roberto Cedillos, Miguel Tabora, Douglas W. Olson, Kayanush Aryana

Faculty Publications

Consumers are becoming aware of functional ingredients such as medicinal herbs, polyphenols, mushrooms, amino acids, proteins, and probiotics more than ever before. Like yogurt and its probiotics, L-glutamine, quercetin, slippery elm bark, marshmallow root, N-acetyl-D-glucosamine, licorice root, maitake mushrooms, and zinc orotate have demonstrated health benefits through gut microbiota. The impact of these ingredients on yogurt starter culture bacteria characteristics is not well known. The objective of this study was to determine the influence of these ingredients on the probiotic characteristics, tolerance to gastric juices and lysozyme, protease activity, and viability of Streptococcus thermophilus STI-06 and Lactobacillus bulgaricus LB-12. Acid …

New Boron Delivery Agents, Annette G. Beck-Sickinger, Daniel P. Becker, Oksana Chepurna, Bhaskar Das, Sebastian Flieger, Evamarie Hey-Hawkins, Narayan Hosmane, Satish S. Jalisatgi, Hiroyuki Nakamura, Rameshwar Patil, Maria Da Graça H. Vicente, Clara Viñas

Faculty Publications

This proceeding article compiles current research on the development of boron delivery drugs for boron neutron capture therapy that was presented and discussed at the National Cancer Institute (NCI) Workshop on Neutron Capture Therapy that took place on April 20-22, 2022. The most used boron sources are icosahedral boron clusters attached to peptides, proteins (such as albumin), porphyrin derivatives, dendrimers, polymers, and nanoparticles, or encapsulated into liposomes. These boron clusters and/or carriers can be labeled with contrast agents allowing for the use of imaging techniques, such as PET, SPECT, and fluorescence, that enable quantification of tumor-localized boron and their use …

Effect Of Stimulator Of Interferon Genes (Sting) Signaling On Radiation-Induced Chemokine Expression In Human Osteosarcoma Cells, Sita S. Withers, Cambri E. Moeller, Cally N. Quick, Chin Chi Liu, Shelby M. Baham, Jayme S. Looper, Ramesh Subramanian, Konstantin G. Kousoulas

Faculty Publications

Cancer cell-intrinsic mechanisms affecting radiation immunomodulation could be exploited to optimize systemic effects of localized radiation. Radiation-induced DNA damage is sensed by cyclic GMP-AMP synthase (cGAS), which ultimately activates stimulator of interferon (IFN) genes (STING). Resultant expression of soluble mediators such as CCL5 and CXCL10 can facilitate recruitment of dendritic cells and immune effector cells into the tumor. The primary objectives of this study were to determine the baseline expression levels of cGAS and STING in OSA cells and evaluate the dependence of OSA cells on STING signaling for eliciting radiation-induced expression of CCL5 and CXCL10. cGAS and STING expression, …

Factors Associated With Knowledge And Experience Of Self-Managed Abortion Among Patients Seeking Care At 49 Us Abortion Clinics, Abigail R.A. Aiken, Luisa Alejandra Tello-Pérez, Melissa Madera, Jennifer E. Starling, Dana M. Johnson, Kathleen Broussard, Elisa Padron, Carol Armelle Ze-Noah, Aleta Baldwin, James G. Scott

Faculty Publications

IMPORTANCE Patients attending US abortion clinics may consider or try self-managing their abortion before coming to the clinic, yet little is known about the factors associated with self-management behavior.

OBJECTIVE To examine the prevalence and factors associated with considering or attempting a self-managed abortion before attending a clinic.

DESIGN, SETTING, AND PARTICIPANTS This survey study included patients obtaining an abortion at 49 independent, Planned Parenthood, and academic-affiliated clinics chosen to maximize diversity in geographic, state policy, and demographic context in 29 states between December 2018 and May 2020. Data were analyzed from December 2020 to July 2021.

EXPOSURES Obtaining an …

Predicting Grocery Store Visits During The Early Outbreak Of Covid-19 With Machine Learning, Ruijie Bian, Pamela Murray-Tuite, Brian Wolshon

Faculty Publications

While non-essential travel was canceled during the coronavirus infectious disease (COVID-19) pandemic, grocery shopping was essential. The objectives of this study were to: 1) examine how grocery store visits changed during the early outbreak of COVID-19, and 2) estimate a model to predict the change of grocery store visits in the future, within the same phase of the pandemic. The study period (February 15–May 31, 2020) covered the outbreak and phase-one re-opening. Six counties/states in the United States were examined. Grocery store visits (in-store or curbside pickup) increased over 20% when the national emergency was declared on March 13 and …

Rise Of The Metaverse's Immersive Virtual Reality Malware And The Man-In-The-Room Attack & Defenses, Martin Vondráček, Ibrahim Baggili, Peter Casey, Mehdi Mekni

Faculty Publications

The allure of the metaverse along with Virtual Reality (VR) technologies and speed at which they are deployed may shift focus away from security and privacy fundamentals. In this work we employ classic exploitation techniques against cutting edge devices to obtain equally novel results. The unique features of the Virtual Reality landscape set the stage for our primary account of a new attack, the Man-in-the-Room (MitR). This attack, realized from a vulnerable social networking application led to both worming and botnet capabilities being adapted for VR with potential critical impacts affecting millions of users. Our work improves the state-of-the-art in …

Gas Hydrates Reserve Characterization Using Thermo-Hydro-Mechanical Numerical Simulation: A Case Study Of Green Canyon 955, Gulf Of Mexico, Sulav Dhakal, Ipsita Gupta

Faculty Publications

The Gulf of Mexico is a widely explored and producing region for offshore oil and gas resources, with significant submarine methane hydrates. Estimates of hydrate saturation and distribution rely on drilling expeditions and seismic surveys that tend to provide either large-scale estimates or highly localized well data. In this study, hydrate reserve characterization is done using numerical simulation at Green Canyon block 955 (GC955). In addition, coupled thermo-hydro-mechanical (THM) simulation results show that hydrate saturation and geobody distribution are determined by the thermodynamic conditions as well as reservoir structures, stratigraphic differences, and permeability differences. Hydrate formation due to upflow of …

Trading Nonenforcement, Ryan Snyder

Faculty Publications

In recent years, federal agencies have increasingly used nonenforcement as a bargaining chip—promising not to enforce a legal requirement in exchange for a regulated party’s promise to do something else that the law doesn’t require. This Article takes an in-depth look at how these nonenforcement trades work, why agencies and regulated parties make them, and the effects they have on social policy. The Article argues that these trades pose serious risks: Agencies often use trading to evade procedural and substantive limits on their power. The trades themselves present fairness problems, both because they tend to reward large, well-connected firms and …

Health Of Nations: Preventing A Post-Pandemic Emerging Markets Debt Crisis, Lev E. Breydo

Faculty Publications

Sixty percent of low-income countries are currently at “high-risk” of insolvency, necessitating debt relief, according to the International Monetary Fund. The enormity of the problem cannot be overstated; a prospective sovereign debt crisis and economic collapse threatens hundreds of millions of people around the world.

At the same time, the tools to address these challenges are wholly inadequate. Typically, debt reduction is effectuated through statutory systems; sovereign debt is a critical exception, as there is no bankruptcy court for countries. Historically, this void was filled through a complex architecture based on custom, ‘soft law,’ and contractual mechanisms. However, that construct …

Menstrual Justice In Theoretical Context, Vivian E. Hamilton

Faculty Publications

This Essay reviews and places into theoretical contexts Bridget Crawford and Emily Waldman’s invaluable book Menstruation Matters. Although the authors themselves do not explicitly label the theoretical approach that undergirds their work, much of Menstruation Matters: Challenging the Law’s Silence on Periods falls within the liberal feminist legal tradition typical of post-civil rights second-wave feminism. Their work also embodies aspects of critical feminist approaches to law. Crawford & Waldman expose the discriminatory effects of facially neutral laws, the limits of formal equality, and the pitfalls of essentializing or making universal claims about categories of individuals—including women and menstruators. In …

Traffic Lights For Catalysis: Stimuli-Responsive Molecular And Extended Catalytic Systems, Grace C. Thaggard, Johanna Haimeri, Roland A. Fischer Prof. Dr., Kyoung Chul Park, Natalia B. Shustova Prof. Dr.

Faculty Publications

The advances made in the field of stimuli-responsive catalysis during the last five years with a focus on the novel recently-emerged directions and applications have been surveyed. Metal-free catalysts and organometallic complexes, as well as biomimetic systems and extended structures, which display switchable catalytic activity for a variety of organic transformations, are discussed. Light-activated systems comprised of photochromic molecules capable of modulating reaction rate, yield, or enantioselectivity based on geometric and electronic changes associated with photoisomerization are the focus of the detailed discussion. Alternative stimuli, including pH and temperature, which could be applied either alone or in combination with light, …

La Virtud Está En El Medio: Observaciones Sobre La Pronunciación De La /S/ En El Español Dominicano, Orlando Alba

Faculty Publications

En esta presentación se describe, con el apoyo de muestras orales, la situación particular, probablemente única en el mundo hispánico, que experimenta la pronunciación de la /s/ en el español dominicano. Mientras en el habla popular la frecuencia de eliminación del segmento se sitúa alrededor del 100%, las emisiones de noticias por televisión, y algunos hablantes cuando se encuentran en situaciones formales, caen en el extremo opuesto, y exhiben un excesivo nivel de 100% de conservación de la variante plena [s]. Entre ambos polos se encuentra la realidad del habla culta natural del país, cuya modalidad es variable. En su …

Capturing Children Food Exposure Using Wearable Cameras And Deep Learning, Shady Elbassuoni, Hala Ghattas Ph.D., Jalila El Ati, Yorgo Zoughby, Aline Semaan, Christelle Akl, Tarek Trabelsi, Reem Talhouk, Houda Ben Gharbia, Zoulfikar Shmayssani, Aya Mourad

Faculty Publications

Children’s dietary habits are influenced by complex factors within their home, school and neighborhood environments. Identifying such influencers and assessing their effects is traditionally based on self-reported data which can be prone to recall bias. We developed a culturally acceptable machine-learning-based data-collection system to objectively capture school-children’s exposure to food (including food items, food advertisements, and food outlets) in two urban Arab centers: Greater Beirut, in Lebanon, and Greater Tunis, in Tunisia. Our machine-learning-based system consists of 1) a wearable camera that captures continuous footage of children’s environment during a typical school day, 2) a machine learning model that automatically …

Experimental Investigation Of Self-Compacting Concrete With Recycled Concrete Aggregate, Sayed Ahmed, Ayman El-Zohairy, Ahmed S. Eisa, Mohamed Abd El-Aziz Badran Mohamed

Faculty Publications

Due to the depletion of natural aggregates and raw materials for contemporary construction, the construction and demolition waste existing in old concrete structures is an imperative problem. Cutting down on exploiting natural aggregates and reusing construction and demolition waste in the concrete industry are solutions to this problem. This paper investigated the replacement of natural coarse aggregate (NCA) with recycled concrete aggregates (RCA) with different ratios (0%, 50%, 75%, and 100%) in producing self-compacting concrete (SCC). Different components of supplementary cementitious materials (SCMs), such as nano-silica (NS), fly ash (FA), and metakaolin (MK), as well as PVA fibers, were incorporated …

Frontal Polymerizations: From Chemical Perspectives To Macroscopic Properties And Applications, Benjamin A. Suslick, Julie Hemmer, Brecklyn R. Groce, Katherine J. Stawiasz, Philippe H. Geubelle, Giulio Malucelli, Alberto Mariani, Jeffrey S. Moore, John A. Pojman, Nancy R. Sottos

Faculty Publications

The synthesis and processing of most thermoplastics and thermoset polymeric materials rely on energy-inefficient and environmentally burdensome manufacturing methods. Frontal polymerization is an attractive, scalable alternative due to its exploitation of polymerization heat that is generally wasted and unutilized. The only external energy needed for frontal polymerization is an initial thermal (or photo) stimulus that locally ignites the reaction. The subsequent reaction exothermicity provides local heating; the transport of this thermal energy to neighboring monomers in either a liquid or gel-like state results in a self-perpetuating reaction zone that provides fully cured thermosets and thermoplastics. Propagation of this polymerization front …

Behavioral Economics And Monetary Wisdom: A Cross-Level Analysis Of Monetary Aspiration, Pay (Dis)Satisfaction, Risk Perception, And Corruption In 32 Nations, Thomas Li-Ping Tang, Zhen Li, Mehmet Ferhat Özbek, Vivien K. G. Lim, Thompson S. H. Teo, Mahfooz A. Ansari, Toto Sutarso, Ilya Garber, Randy Ki-Kwan Chiu, Brigitte Charles-Pauvers, Caroline Urbain, Roberto Luna-Arocas, Jingqiu Chen, Ningyu Tang, Theresa Li-Na Tang, Fernando Arias-Galicia, Consuelo Garcia De La Torre, Peter Vlerick, Adebowale Akande, Abdulqawi Salim Al-Zubaidi, Ali Mahdi Kazem, Mark G. Borg, Bor-Shiuan Cheng, Linzhi Du, Abdul Hamid Safwat Ibrahim, Kilsun Kim, Eva Malovics, Richard T. Mpoyi, Obiajulu Anthony Ugochukwu Nnedum, Elisaveta Gjorgji Sardžoska, Michael W. Allen, Rosário Correia, Chin-Kang Jen, Alice S. Moreira, Johnston E. Osagie, Aahad M. Osman-Gani, Ruja Pholsward, Marko Polic, Petar Skobic, Allen F. Stembridge, Luigina Canova, Anna Maria Manganelli, Adrian H. Pitariu, Francisco José Costa Pereira

Faculty Publications

Corruption involves greed, money, and risky decision-making. We explore the love of money, pay satisfaction, probability of risk, and dishonesty across cultures. Avaricious monetary aspiration breeds unethicality. Prospect theory frames decisions in the gains-losses domain and high-low probability. Pay dissatisfaction (in the losses domain) incites dishonesty in the name of justice at the individual level. The Corruption Perceptions Index, CPI, signals a high-low probability of getting caught for dishonesty at the country level. We theorize that decision-makers adopt avaricious love-of-money aspiration as a lens and frame dishonesty in the gains-losses domain (pay satisfaction-dissatisfaction, Level 1) and high-low probability (CPI, Level …

Simulations Of Morphology Control Of Self-Assembled Amphiphilic Surfactants, Qinyu Zhu, Douglas R. Tree

Faculty Publications

One of the grand challenges of amphiphilic self-assembly is the design of ordered structures whose morphology or shape can be explicitly and dynamically controlled by adjusting the properties of the amphiphiles or their surroundings. Such a capacity would enable researchers to create synthetic systems with functionality that meets or exceeds biological cells, and provide a robust platform for a broad range of engineering applications such as artificial tissues, drug delivery, and separation membranes. Despite significant progress, important fundamental questions remain unanswered, due in part to the limited resolution and the restricted parameter spaces that are readily accessible in experiments. Computational …

Simulations Of Morphology Control Of Self-Assembled Amphiphilic Surfactants, Qinyu Zhu, Douglas R. Tree

Faculty Publications

One of the grand challenges of amphiphilic self-assembly is the design of ordered structures whose morphology or shape can be explicitly and dynamically controlled by adjusting the properties of the amphiphiles or their surroundings. Such a capacity would enable researchers to create synthetic systems with functionality that meets or exceeds biological cells, and provide a robust platform for a broad range of engineering applications such as artificial tissues, drug delivery, and separation membranes. Despite significant progress, important fundamental questions remain unanswered, due in part to the limited resolution and the restricted parameter spaces that are readily accessible in experiments. Computational …

Control Education For Societal-Scale Challenges: A Community Roadmap, John Anthony Rossiter, Christos G. Cassandras, João Hespanha, Sebastian Dormido, Luis De La Torre, Gireeja Ranade, Antonio Visioli, John Hedengren, Richard M. Murray, Panos Antsaklis, Francoise Lamnabhi-Lagarrigue, Thomas Parisini

Faculty Publications

This article focuses on extending, disseminating and interpreting the findings of an IEEE Control Systems Society working group looking at the role of control theory and engineering in solving some of the many current and future societal challenges. The findings are interpreted in a manner designed to give focus and direction to both future education and research work in the general control theory and engineering arena, interpreted in the broadest sense. The paper is intended to promote discussion in the community and also provide a useful starting point for colleagues wishing to re-imagine the design and delivery of control-related topics …

The Mechanics Of Share Repurchases Or How I Stopped Worrying And Learned To Love Stock Buybacks, Richard A. Booth

Faculty Publications

Stock repurchases by issuing corporations have always been controversial. They have become even more so recently because of the perception that the excess funds used to finance them have come from tax cuts and other sources (such as government bailouts) that were intended to stimulate reinvestment or enhanced wages and benefits for workers. As a result, critics have proposed amendments to tax law that discourage buybacks (and possibly dividends as well). The theory is that the benefits of such distributions go mostly to executives (who are compensated in large part with equity) and to already wealthy stockholders. The controversy is …