Digital Commons Network^™

Cryptotanshinone Inhibits Cancer Cell Proliferation By Suppressing Mammalian Target Of Rapamycin - Mediated Cyclin D1 Expression And Rb Phosphorylation, Wenxing Chen, Yan Luo, Lei Liu, Hongyu Zhou, Baoshan Xu, Xiuzhen Han, Tao Shen, Zhijun Liu, Yin Lu, Shile Huang

Faculty Publications

Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, little is known about its anticancer mechanism. Here, we show that CPT inhibited cancer cell proliferation by arresting cells in G1-G0 phase of the cell cycle. This is associated with the inhibition of cyclin D1 expression and retinoblastoma (Rb) protein phosphorylation. Furthermore, we found that CPT inhibited the signaling pathway of the mammalian target of rapamycin (mTOR), a central regulator of cell proliferation. This is evidenced by the findings that CPT inhibited type I insulin-like growth factor I- or 10% fetal bovine …

Malware Type Recognition And Cyber Situational Awareness, Thomas E. Dube, Richard A. Raines, Gilbert L. Peterson, Kenneth W. Bauer, Michael R. Grimaila, Steven K. Rogers

Faculty Publications

Current technologies for computer network and host defense do not provide suitable information to support strategic and tactical decision making processes. Although pattern-based malware detection is an active research area, the additional context of the type of malware can improve cyber situational awareness. This additional context is an indicator of threat capability thus allowing organizations to assess information losses and focus response actions appropriately. Malware Type Recognition (MaTR) is a research initiative extending detection technologies to provide the additional context of malware types using only static heuristics. Test results with MaTR demonstrate over a 99% accurate detection rate and 59% …

Body Image In Middle-Aged Mormon Women: A Comparative Case Study, Janette Olsen

Faculty Publications

Body image is a multifaceted construct developed from perceived experiences and personal and cultural attitudes towards the body. Women are more vulnerable than men to internal and external influences regarding negative body image. A qualitative comparative case study design was utilized to explore how 10 lifelong, middle-aged LDS women, either married (n=5) with children or single, never married (n=5), experienced body image through their perceptions of religiosity and spirituality. The participants lived along the Wasatch Front in Utah and were recruited through known LDS gatekeepers. Each participant completed three in-person interviews and three audio or paper journals, which were transcribed …

Why The Supreme Court Cares About Elites, Not The American People, Lawrence Baum, Neal Devins

Faculty Publications

Supreme Court Justices care more about the views of academics, journalists, and other elites than they do about public opinion. This is true of nearly all Justices and is especially true of swing Justices, who often cast the critical votes in the Court’s most visible decisions. In this Article, we will explain why we think this is so and, in so doing, challenge both the dominant political science models of judicial behavior and the significant work of Barry Friedman, Jeffrey Rosen, and others who link Supreme Court decision making to public opinion.

Analytical Solutions For Efficient Interpretation Of Single-Well Push-Pull Tracer Tests, Junqi Huang, John A. Christ, Mark N. Goltz

Faculty Publications

Single-well push-pull tracer tests have been used to characterize the extent, fate, and transport of subsurface contamination. Analytical solutions provide one alternative for interpreting test results. In this work, an exact analytical solution to two-dimensional equations describing the governing processes acting on a dissolved compound during a modified push-pull test (advection, longitudinal and transverse dispersion, first-order decay, and rate-limited sorption/partitioning in steady, divergent, and convergent flow fields) is developed. The coupling of this solution with inverse modeling to estimate aquifer parameters provides an efficient methodology for subsurface characterization. Synthetic data for single-well push-pull tests are employed to demonstrate the utility …

Social Relationships And Mortality Risk: A Meta-Analytic Review, Timothy B. Smith, Julianne Holt-Lunstad, J. Bradley Layton

Faculty Publications

Background: The quality and quantity of individuals' social relationships has been linked not only to mental health but also to both morbidity and mortality. Objectives: This meta-analytic review was conducted to determine the extent to which social relationships influence risk for mortality, which aspects of social relationships are most highly predictive, and which factors may moderate the risk. Data Extraction: Data were extracted on several participant characteristics, including cause of mortality, initial health status, and pre-existing health conditions, as well as on study characteristics, including length of follow-up and type of assessment of social relationships. Results: Across 148 studies (308,849 …

Structural, Nmr Spectroscopic, And Computational Investigation Of Hemin Loading In The Hemophore Hasap From Pseudomonas Aeruginosa, Grace Jepkorir, Juan Carlos Rodríguez, Huan Rui, Wonpil Im, Scott Lovell, Kevin P. Battaile, Aileen Y. Alontaga, Erik T. Yukl, Pierre Moënne-Loccoz, Mario Rivera

Faculty Publications

When challenged by low-iron conditions several Gram-negative pathogens secrete a hemophore (HasA) to scavenge hemin from its host and deliver it to a receptor (HasR) on their outer membrane for internalization. Here we report results from studies aimed at probing the structural and dynamic processes at play in the loading of the apo-hemophore secreted by P. aeruginosa (apo-HasAp) with hemin. The structure of apo-HasAp shows a large conformational change in the loop harboring axial ligand His32 relative to the structure of holo-HasAp, whereas the loop bearing the other axial ligand, Tyr75, remains intact. To investigate the role played by the …

Sub-Wavelength Plasmonic Crystals: Dispersion Relations And Effective Properties, Santiago P. Fortes, Robert P. Lipton, Stephen P. Shipman

Faculty Publications

We obtain a convergent power series expansion for the first branch of the dispersion relation for sub-wavelength plasmonic crystals consisting of plasmonic rods with frequency-dependent dielectric permittivity embedded in a host medium with unit permittivity. The expansion parameter is η=kd =2φdλ, where k is the norm of a fixed wavevector, d is the period of the crystal and λ is the wavelength, and the plasma frequency scales inversely to d, making the dielectric permittivity in the rods large and negative. The expressions for the series coefficients (also called dynamic correctors) and the radius of convergence in η are explicitly related …

Beyond Employment And Income: The Association Between Young Adults’ Finances And Marital Timing, Jeffrey P. Dew, Joseph Price

Faculty Publications

This study tested an extension of the theory of marital timing (Oppenheimer, Am J Sociol 94:563–591, 1988) by assessing whether visible and less visible financial assets and debt mediated the relationship between employment and the likelihood of marriage. We conducted these prospective, longitudinal analyses using a sample of 1,522 never-married young adults from the National Survey of Families and Households. For participants who were not cohabiting at Wave 1, financial issues such as car values predicted marriage but did not mediate the relationship between work hours, occupational prestige, and the likelihood of marriage. For cohabiting participants, employment factors were the …

What Difference Does It Make?: E-Learning And Faith Community, Mary E. Hess

Faculty Publications

By adopting a relational model of teaching and learning we can better align our programs of Christian education with our fundamental understandings of the faith. Digital technologies can help us do this more fully and more effectively.

Social Networking And Church Systems, Dwight J. Zscheile

Faculty Publications

Most existing church systems were shaped by bureaucratic organizational paradigms of a previous century that are coming under increasing stress today. The shift to a network society brings both profound challenges and great opportunities to the church in our culture.

Talking Body Parts And Missing Commodities: Cinematic Complexes And Sylvia Plath, Vidhu Aggarwal

Faculty Publications

No abstract provided.

Is Hong Kong Democratizing, Dexter S. Boniface, Ilan Alon

Faculty Publications

We argue that the transition to Chinese authority has not undermined democratic governance in Hong Kong and that voice and accountability have improved since the handover. We seek to explain this surprising result and conclude with a discussion of the implications of our findings for China, Taiwan, and cross-strait relations.

Accounting For Historical Forces In The Effort To Align Law With Science, Derek W. Black

Faculty Publications

No abstract provided.

Financing The Next Silicon Valley, Darian M. Ibrahim

Faculty Publications

Silicon Valley’s success has led other regions to attempt their own high-tech transformations, yet most imitators have failed. Entrepreneurs may be in short supply in these “non-tech” regions, but some non-tech regions are home to high-quality entrepreneurs who relocate to Silicon Valley due to a lack of local financing for their start-ups. Non-tech regions must provide local finance to prevent entrepreneurial relocation and reap spillover benefits for their communities. This Article compares three possible sources of entrepreneurial finance—private venture capital, state-sponsored venture capital, and angel investor groups—and finds that angel groups have distinct advantages when it comes to funding innovation …

Forward: Symposium On Broke And Broken: Can We Fix Our State Indigent Defense System?, Rodney J. Uphoff

Faculty Publications

The Symposium presenters and commentators, most of whom had worked at some point in their career as a public defender, brought a wealth of experience to the discussion. While the presentations and comments made that day, together with the articles that follow in this Symposium issue, do not provide any quick fix or easy solution, they do offer some important lessons for lawmakers to consider as states struggle to improve the plight of indigent defenders and their clients.

Co-Varying Patterns Of Physical Activity And Sedentary Behaviors And Their Long-Term Maintenance Among Adolescents, Jihong Liu, Jinseok Kim, Natalie Colabianchi, Andrew Ortaglia, Russell R. Pate

Faculty Publications

Background: We examined the covarying patterns of physical activity and sedentary behaviors among adolescents and their long-term maintenance. Methods: Data came from the National Longitudinal Study of Adolescent Health (1995-2002). We used latent class analysis to identify distinct covarying patterns in adolescence. Logistic regression models were used to predict odds of meeting moderate-to-vigorous physical activity (MVPA) recommendations (≥5 bouts/week) and exceeding screen time guidelines (>2 hours/day) 6 years later based on their adolescent class profile. Results: Five classes for each gender were identified and labeled as low physical activity (PA)/low sedentary behaviors (SED), moderate (Mod) PA/high (HI) SED, Mod …

An Inverse Kinematic Mathematical Model Using Groebner Basis Theory For Arm Swing Movement In The Gait Cycle, Kimberly D. Kendricks, Adam M. Fullenkamp, Robert Mcgrellis, Jonathan Juhl, Ronald F. Tuttle

Faculty Publications

Two important indicators in the gait cycle: arm swing and foot placement, when isolated, provide key information about future behaviors in the gait cycle. Through video captured data, the INSPIRE (Integration of a Sensor Package for Identifying Radical Extremists) project seeks to identify gait characteristics in arm and leg swing movement to recognize threatening individuals. In particular, one approach discussed in this paper uses Groebner Basis Theory to model arm swing movement in the gait cycle. Through inverse kinematics, joint configurations of the shoulder and elbow are found to place the wrist at a specific position and orientation in the …

Voices From The Dome: Hyveth Williams, Hyveth Williams

Faculty Publications

No abstract provided.

Simulating Windows-Based Cyber Attacks Using Live Virtual Machine Introspection, Dustyn A. Dodge, Barry E. Mullins, Gilbert L. Peterson, James S. Okolica

Faculty Publications

Static memory analysis has been proven a valuable technique for digital forensics. However, the memory capture technique halts the system causing the loss of important dynamic system data. As a result, live analysis techniques have emerged to complement static analysis. In this paper, a compiled memory analysis tool for virtualization (CMAT-V) is presented as a virtual machine introspection (VMI) utility to conduct live analysis during simulated cyber attacks. CMAT-V leverages static memory dump analysis techniques to provide live system state awareness. CMAT-V parses an arbitrary memory dump from a simulated guest operating system (OS) to extract user information, network usage, …

Openness As Catalyst For An Educational Reformation, David Wiley

Faculty Publications

The word open is receiving a lot of attention in education circles. Openness in higher education has been discussed recently by writers in the Chronicle of Higher Education, the New York Times, EDUCAUSE Review, and EQ, among other publications. In January 2010, The Horizon Report, produced by the New Media Consortium (NMC) and the EDUCAUSE Learning Initiative (ELI), declared that open content will “reach mainstream use” in higher education within the next twelve months. But what does that mean? What is this open we keep hearing about?

Reading The Product: Warnings, Disclaimers, And Literary Theory, Laura A. Heymann

Faculty Publications

No abstract provided.

Entrepreneur, Leticia Camacho

Faculty Publications

Launched by Entrepreneur Media, a leading publisher of entrepreneurship magazines and books, Entrepreneur contains original content and current, relevant resources related to starting and running a small business. The main page contains many links from tabs at the top of the page and also from a topic menu along the left side.

International Service For Human Rights Dossier On The International Criminal Court, Beth Van Schaack

Faculty Publications

This white paper discusses the negotiations during the United Nations Diplomatic Conference of Plenipotentiaries on the Establishment of an International Criminal Court held in Rome, Italy in 1998 that resulted in the establishment of the International Criminal Court (ICC). It was drafted in my capacity as head of the delegation of the Geneva-based International Service for Human Rights on the basis of my delegation's notes, our discussions with delegates, official Conference documents, and reports issued by NGOs and the Coalition for an International Criminal Court during the Conference. The paper provides a brief overview of the Statute with an emphasis …

A Novel Ionic Liquid-Supported Schiff Base Ligand Applied In The Pd-Catalyzed Suzuki-Miyaura Coupling Reaction, Bin Li, Yi Qun Li, Jia Zheng

Faculty Publications

A series of novel ionic liquid-supported Schiff bases have been prepared from the condensation of aromatic aldehydes with the ionic liquid 1-(2-aminoethyl)-3-methylimidazolium hexafluorophosphate. The as-prepared ionic liquid-supported salicyladehyde Schiff base L3 was further investigated as a ligand for the Pd-catalyzed Suzuki-Miyaura coupling reaction under air in ethanol solution, giving biaryls in good to excellent yields. The PdCl 2/ligand L3 catalytic system could be reused at least 5 times without losing its activity. © ARKAT USA, Inc.

Proactive Parenting Practices During Early Adolescence: A Cluster Approach, Laura M. Padilla-Walker, Katherine J. Christensen, Randal D. Day

Faculty Publications

The purpose of the current study was to explore clusters of proactive parenting practices, and how they might vary as a function of parental demographics, the quality of the parent– child relationship, and the traits and behaviors of the adolescent child. Data were taken from the Flourishing Families Project, which includes 500 families with an early adolescent child (M age ¼ 11.49). Findings suggested that there were four clusters of parents, and patterns were similar for mothers and fathers. Findings also suggested that proactive clusters varied primarily as a function of demographics of the parent (e.g., religiosity, ethnicity, education) and …

The 2010 Racial And Gender Report Card: National Basketball Association, Richard Lapchick, Christopher Kaiser, Christina Russell, Natalie Welch

Faculty Publications

The Institute for Diversity and Ethics in Sport (TIDES) at the University of Central Florida publishes the Racial and Gender Report Card to indicate areas of improvement, stagnation, and regression in the racial and gender composition of professional and college sports personnel and to contribute to the improvement of integration in front office and college athletics department positions. Each year the National Basketball Association (NBA) has made progress in almost all categories examined for both race and gender.

The NBA continues to set the standard for the industry as the leader on issues related to race and gender hiring practices. …

Proposed Combination Of Comcast And Nbc-Universal, Allen S. Hammond Iv, United States House Of Representatives, Committee On The Judiciary

Faculty Publications

Hammond's testimony begins on p. 124.

Abundance And Ecological Significance Of The Clam Rangia Cuneata (Sowerby, 1831) In The Upper Barataria Estuary (Louisiana, Usa), Wai Hing Wong, Nancy N. Rabalais, R. Eugene Turner

Faculty Publications

We proposed that Rangia cuneata (Sowerby, 1831) is an important estuarine bivalve with ecological significance in three coastal lakes in Barataria Bay, Gulf of Mexico—Lake Cataouatche, Lake Salvador and Lac des Allemands. Our goals were to determine the abundance and distribution of Rangia in these lakes and to measure clearance times to elucidate its potential impacts on phytoplankton communities. The estimated average densities of R. cuneata in Lake Cataouatche, Lake Salvador, and Lac des Allemands were 63, 157, and 107 individuals m−2, respectively, which is 30% lower than that observed in nearby Lake Pontchartrain. The size of clams in Lake …

Why We Don’T Understand The Rule Of Law Or Explaining The Rule Of Law: A Practice In Search Of A Theory, Noel B. Reynolds

Faculty Publications

This lecture summarizes the main attempts to formulate an understanding of rule of law among legal theorists and explains why they fail to account for the real experience of law. It also explains key characteristics of law that need to be recognized in an adequate account of the rule of law.