Digital Commons Network^™

Role Of Wadsley Defects And Cation Disorder To Enhance Monb12O33 Diffusion, Cj Sturgill, Manish Kumar, Nima Karimitari, Iva Millisavljevic, Coby S. Collins, Aaron Hegler, Hsin-Yun Joy Chao, Santosh Kiran Balijepalli, Scott T. Misture, Christopher Sutton, Morgan Stefik

Faculty Publications

Wadsley-Roth (WR) niobates have emerged as high-rate anode materials that can combine rapid ionic diffusion with good electronic conductivity. WR compounds have been defect-enhanced by limited annealing, however, such materials often contain multiple types of defects. In particular, both Wadsley defects (variable block size) and transition metal disorder have the potential to modify transport rates, however the corresponding effects are not well understood mechanistically. Here, MoNb12O33 (MNO) was calcined at two different temperatures to compare a defect-rich condition (MNO-800) with a proximal order-rich condition (MNO-900) as assessed through XRD, XANES, EXAFS, and STEM characterizations. Galvanostatically cycled lithium half cells of …

First-Order Axial Perturbation Of The Reissner–Nordström Metric Against A Possible Parity-Violating Gravity Background, Abhishek Rout, Brett David Altschul

Faculty Publications

We study axial perturbations of Reissner–Nordström black holes within the general frame-work of parity-violating modified gravity theories. We derive the governing equations for a class of frame-dragging perturbations, focusing on the symmetry structure and radial dependence of the perturbed metric component, describing its behavior across three distinct regions: near the singularity (r → 0), between the inner and outer Reissner–Nordström horizons (r− < r < r+), and in the asymptotic exterior regime (r → ∞). Using a combination of analytical and numerical methods, we analyze the solutions for varying black hole charge-to-mass ratios (Q/M) and angular momentum parameters (l). Key findings include the suppression of perturbations by the electromagnetic field for higher Q/M; the emergence of radial resonance-like behavior for specific l values; and a high degree of symmetry for solutions in the extremal limit (Q/M ∼ 1), attributed to the AdS2 × S 2 near-horizon geometry. The WKB approximation is employed to study the high-l regime, revealing quantized radial resonance modes and singular behavior in the extremal limit. Additionally, we explore the role of boundary conditions and the possibility of a Chern–Simons field Θ as the source of the parity violation, showing that consistency and the behavior of the perturbations under time reversal demand a constant field (and thus no actually observable Chern–Simons effects) at leading order. These results provide a basis for further analysis of the stability and dynamical properties of charged black holes in parity-violating theories, with potential experimental signatures in gravitational wave observations.

Dietary Inflammatory Index And Objective Disease Activity In Ibd: No Association Found, Rúbia Moresi Vianna De Oliveira, Ana Carolina Junqueira Vasques, Stefhani Andrioli Romero, Nitin Shivappa Mbbs, Mph, Ph.D., Michael David Wirth, James Hébert Scd, Glaucia Fernanda Soares Ruppert Reis, Cristiane Kibune Nagasako

Faculty Publications

Background

Inflammatory Bowel Disease (IBD) involves genetic and environmental factors, but the relationship between disease activity, adiposity, and diet remains unclear.

Objective

To investigate the association between endoscopic/radiological activity of IBD, body adiposity, and the Dietary Inflammatory Index with or without adjustment for energy density (E-DII or DII).

Method

An observational, cross-sectional study was carried out. Endoscopic activity was defined by an endoscopic Mayo score >2, Crohn’s Disease Endoscopic Index of Severity (CDEIS) > 5, and/or the presence of a deep ulcer in any intestinal segment. Body adiposity was estimated using the body mass index, waist circumference, and waist-hip ratio (WHR). …

Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Of Multiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qin Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Et. Al.

Faculty Publications

No abstract provided.

Analogy2kg: An Automatic Pipeline For Deriving Knowledge Graphs From Long-Text Analogies, Kara Combs, Lance E. Champagne, Bruce A. Cox, Christine M. Schubert Kabban, Trevor Bihl, Grace Lemming

Faculty Publications

Analogical reasoning is an increasingly popular, lightweight solution to enable large language model (LLM)-level reasoning without computational complexity. Still, it has yet to be adopted due to its reliance on strictly hand-formatted data. Therefore, we propose Analogy2KG (“Analogy to Knowledge Graph”), as an automatic pipeline that transforms text into a KG format via a fine-tuned version of information extraction (IE) algorithms for long-text analogies. The need to verify that the complex underlying analogical structure of the data is maintained was done via paired samples tests in the creation and validation of this pipeline. Graph density was used to evaluate the …

Using Mobile Devices To Support Outdoor Stem Learning In Rural Contexts: An Embedded Mixed-Methods Study, Jayson Seaman, Amanda Bastoni, Andrew D. Coppens, Cindy L. Hartman, Courtney Lachaine, Katelyn Moscouver, Janet Gronneberg

Faculty Publications

Background: Rural youth face barriers to involvement in effective Science, Technology, Engineering, and Math (STEM) learning experiences, leading to persistent underrepresentation in STEM fields. Purpose: This study examined the feasibility of using mobile devices to engage rural youth in informal STEM learning (ISL) during free-choice, outdoor recreational activities. We assessed outcomes of a 10-month intervention related to STEM interest, identity, and future planning. Method: Fifty-four youth ages 12 to 17 completed monthly STEM challenges delivered via a mobile platform, aligned with connected learning and free-choice learning principles. Surveys measured pre/post changes in STEM supports, STEM confidence, and …

Remote Language Assessment In School-Age Children With Phelan–Mcdermid Syndrome And Genotype–Phenotype Correlation, Sarah Quadri-Valverde, Jessica Klusek Ph.D., Ccc-Slp, Linda D. Ward, Diana Ivankovic, Nancy Powers, Vijay Shankar, Rachel A. Lyman, Trudy F.C. Mackay, William Bridges, Katy Phelan, Chris Rogers, Luigi Boccuto, Sara M. Sarasua

Faculty Publications

People with Phelan–McDermid syndrome (PMS) have reduced speech and language abilities, yet little research has profiled the communication abilities in this population. The purpose of this study was threefold: identifying the language and communication profiles of school-aged children with PMS, identifying genetic contributions to language and communication abilities, and determining the feasibility of remote data collection for research purposes. A speech language pathologist used standardized assessments and direct evaluations by video conferencing to evaluate language and communication abilities. Sixteen children and adolescents were evaluated: 5 with SHANK3 pathogenic variants, 9 with 22q13 deletions including SHANK3 (PMS-SHANK3 related), and 2 …

Examining The Relationships Between Students’ Achievement Goals And Their Academic Achievement In An Oer-Based Course: A Person-Centered Approach, Hengtao Tang Ph.D., Yan Yang, Yu Bao

Faculty Publications

Open Educational Resources (OER) have emerged as a cost-effective alternative to traditional commercial textbooks in higher education, towards the goal of alleviating college students’ financial burden of educational expenses. However, mixed findings about the influences of the integration of OER on student learning are present. To address the gap, this study investigated whether student motivation in OER served as a latent factor that impacts their academic achievement in online asynchronous courses offered in public universities. Particularly, this study (N = 247) implemented an advanced person-centered approach—stepwise latent class analysis—to profile student achievement goals in an OER-based course and examined their …

Employing A Hysteresis Approach To Analyze Shifts In Tree Physiological Thresholds In Response To Drought, Mauro Brum, Annie Deslauriers, Matthew A. Vadeboncoeur, Tanner Frost, David Moore, Caroline Rodrigues Da Silva, Daniel B. Metcalfe, Heidi Asbjornsen

Faculty Publications

Drought‐induced tree mortality underscores the need for improved physiological models to predict tree responses to water stress. We employed a hysteresis modelling approach analyzing diel water absorption and desorption cycles to understand drought‐induced shifts in physiological thresholds. We applied this approach to sap flow (Js), stem diameter fluctuation (SDF), stem volumetric water content fluctuation (SVWCF), and vapour pressure deficit (VPD), datasets from two throughfall reduction experiments in contrasting ecosystems: a cloud forest (Peru) and a temperate forest (USA). Using a generalised transcendental equation, we quantified five diurnal hysteresis loops (Js:VPD, Js:SDF, Js:SVWCF, SDF:VPD, SVWCF:VPD) and derived hysteresis parameters (centroids, area, …

New Avenues For |Δb=2| Processes Beyond Neutron-Antineutron Oscillations, Arnau Basi Beneito, Svjetlana Fajfer, Alexey A. Petrov

Faculty Publications

We explore baryon-number-violating (|∆B| = 2) processes beyond the well-known neutron-antineutron (n-n̄) oscillations, focusing on the Λ-Λ̄ system. The presence of a strange quark in the Λ baryon introduces a new set of six-quark operators roughly of the form (uds)², which are different from the (udd)² operators responsible for n-n̄ oscillations. Using the Standard Model Effective Field Theory (SMEFT), we classify all dimension-9 operators that cause |∆B| = 2  transitions and study their UV completions mediated by exotic scalar fields with trilinear interactions. We demonstrate that …

Rewriting The Rules: Game-Based Learning For Affective And Cognitive Student Engagement In An Undergraduate History Course, Rachel Hoke, James Risk

Faculty Publications

Constructivist psychology has long demonstrated the potential for play to offer various benefits to learning. This study introduced active game-based learning experiences, in the form of role-playing games, into an undergraduate history course that also included passive lecture and discussion elements. Mixed methods student feedback surveys were used to examine the impacts of game-based learning on students’ affective and cognitive engagement in the course and offer a comparison between the lecture and game-based learning experiences. Qualitative data were analyzed through the paradigm of Mohsen, Abdollahi, and Omar’s (2019, 518-520) framework for educational value, including affective evaluation, conceptual understanding, skill development, …

Efficient Energy-Stable Discontinuous Galerkin Schemefor The Non-Isothermal Cahn–Hilliard–Navier–Stokestwo-Phase Fluid Flow System, Guang-An Zou, Meiting Wang, Kejia Pan, Yin Yang, Xiaofeng Yang

Faculty Publications

In this article, we propose a novel numerical framework for the non-isothermal Cahn–Hilliard–Navier–Stokes two-phase flow system, which couples the incompressible Navier–Stokes equations, the Cahn–Hilliard phase-field equation, and the heat transport equation to capture temperature-dependent two-phase flow dynamics. The pro-posed scheme achieves three major advances: (i) unconditional energy stability through a combined scalar auxiliary variable (SAV) and zero-energy-contribution (ZEC) approach, (ii) linearity and full decoupling of all variables while using a second-order temporal discretization, and (iii) efficient implementation via discontinuous Galerkin (DG) spa-tial discretization together with a second-order projection method for the Navier–Stokes equations. We rigorously prove the unconditional energy stability …

Congruence Properties Modulo Prime Powers For A Class Of Partition Functions, Matthew Boylan, Swati .

Faculty Publications

Let p be prime, and let p_[1,p](n) denote the function whose generating function is

∏ _n≥1 (1 − qⁿ)⁻¹ (1 − q^pn)⁻¹.

This function and its generalizations p_[c^r,d^m](n) are the subject of study in several recent papers. Let ℓ ≥ 5, let j ≥ 1, and let p ∈ {2, 3, 5}. In this paper, we prove that the generating function for p_[1,p](n) in the progression β_{p,ℓ,j …}

Ulk4 And Cdkn2a Polymorphisms Influence The Risk Of Developing Monoclonal Gammopathy Of Undetermined Significance, José Manuuel Sánchez-Maldonado, Angelica Macauda, Antonio José Cabrera-Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany Van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz-Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero-Fernández, Elena Cabezudo, Fernando Reyes-Zurita, Alyssa I. Clay-Gilmour, Et. Al.

Faculty Publications

Monoclonal gammopathy of undetermined significance (MGUS) is a necessary precursor condition to multiple myeloma (MM). Given the role of autophagy in modulating MM risk, we investigated whether genetic variation in autophagy-related genes influences susceptibility to MGUS. We analyzed the association of 34,042 common autophagy-related single nucleotide polymorphisms (SNPs) with MGUS across six independent cohorts, five from Europe and one from North America, comprising 2317 MGUS cases and 282,358 controls. We also assessed their impact on immune parameters, including absolute counts of 91 blood-derived immune cell subsets and 103 circulating immunological proteins. Meta-analysis revealed a genome-wide significant association between the ULK4 …

Impact Of Medicaid Enrollment Timing On Tumor Stage At Diagnosis And Survival In Breast, Colorectal, And Lung Cancer, Gabriel A. Benavidez, Stella Coker Watson Self Ph.D., Ms, Anthony Alberg Ph.D., M.P.H., Janice Probst, Jan Marie Eberth

Faculty Publications

Background: Medicaid-insured patients experience higher rates of late-stage cancer diagnosis and worse survival than non-Medicaid patients. The impact of Medicaid enrollment timing on cancer outcomes is less clear. This study examines the association between Medicaid enrollment and timing with tumor stage and cancer-specific survival for breast, colorectal, and lung cancers. Methods: We analyzed SEER-Medicaid linked data for 276,755 breast, 104,784 colorectal, and 101,058 lung cancer patients < 65 years of age. Patients were categorized as non-Medicaid enrollees, pre-diagnosis enrollees (≥12 months before), or post-diagnosis enrollees (≤12 months after). Multivariable logistic regression estimated odds ratios of late-stage diagnosis, and cause-specific Cox proportional hazards models were used to assess cancer-specific survival, adjusting for demographic and socioeconomic factors. Results: Compared to non-Medicaid enrollees, post-diagnosis enrollees had the highest odds of late-stage diagnosis (breast cancer: OR: 3.41; colorectal cancer: OR: 3.78; lung cancer: OR: 1.87). Pre-diagnosis enrollees also had increased odds, but the …

Rural–Urban Differences In Cognitive Outcomes Among Older Adults: The Roles Of Falls And Depressive Symptoms, Ayse Malatyali, Tom Cidav, Lisa A.K. Wiese, Jian Zou, Monique J. Brown Ph.D., Mph, Junfeng Ma, Breno S. Diniz, Ladda Thiamwong

Faculty Publications

Background: Older adults with Alzheimer’s Disease and Related Dementias (ADRD) experience a higher risk of falls. However, research lacks evidence on the effect of fall exposure on cognitive impairment and dementia. We investigated the association of falls and depressive symptoms with cognitive impairment and dementia in a nationally representative sample. Methods: We analyzed data from 6221 participants (age ≥ 65) in the Health and Retirement Study (HRS) from the 2018–2020 waves, using Multinomial logistic regression models. Measures included the HRS health status questionnaire, HRS cognition scale, and the Center for Epidemiological Studies Depression scale. Results: Prevalence of fall exposure across …

Rural–Urban Differences In Cognitive Outcomes Among Older Adults: The Roles Of Falls And Depressive Symptoms, Ayse Malatyali, Tom Cidav, Lisa A.K. Wiese, Jian Zou, Monique J. Brown Ph.D., Mph, Junfeng Ma, Breno S. Diniz, Ladda Thiamwong

Faculty Publications

Background: Older adults with Alzheimer’s Disease and Related Dementias (ADRD) experience a higher risk of falls. However, research lacks evidence on the effect of fall exposure on cognitive impairment and dementia. We investigated the association of falls and depressive symptoms with cognitive impairment and dementia in a nationally representative sample. Methods: We analyzed data from 6221 participants (age ≥ 65) in the Health and Retirement Study (HRS) from the 2018–2020 waves, using Multinomial logistic regression models. Measures included the HRS health status questionnaire, HRS cognition scale, and the Center for Epidemiological Studies Depression scale. Results: Prevalence of fall exposure across …

Characterizing Atmospheric Turbulence With The Lunar Step Response Method, Patrick D. Carattini, Caleb J. Stilp, Katelyn M. Atkinson, Stephen C. Cain

Faculty Publications

Most methods that astronomers use to characterize the strength of atmospheric turbulence in and around their observatories use differential image motion monitors observing a star to provide the necessary data for the measurement. With the Moon becoming a greater national priority, the need to characterize atmospheric paths between observatories on Earth and the Moon is potentially going to grow in the future. To this end, the differential image motion monitor is not an ideal instrument for characterizing turbulence along paths between observatories and the Moon as the bright Moon makes it difficult to detect and locate stars in its vicinity. …

Main-Chain Ion-Pair Polybenzimidazole Membranes Enabling Reduced-Temperature Ht-Pemfc Operation (Down To 120°C), Huina Lin, Brian C. Benicewicz

Faculty Publications

Proton exchange membrane (PEM) fuel cells are promising for clean and efficient energy conversion across diverse applications. High-temperature PEM fuel cells (HT-PEMFCs) using phosphoric acid (PA)-doped polybenzimidazole (PBI) can operate up to 200°C, but at lower temperatures, water-induced PA loss often leads to performance degradation and reduced durability. In this work, we present a new class of main-chain ion-pair PBI membranes by integrating the imidazolium-biphosphate ion-pair units directly into the PBI backbone. This design results in membranes with high acid content, stronger acid-polymer interactions and stabilized acid retention. In single-cell tests, the Im⁺-PBI15-3 wt.% exhibits peak power densities …

Generation Of Inner Core Anisotropy By Anisotropic Thermal Conductivity Of Iron Crystals, Prajna Paramita Das, Bruce Buffett, Daniel A. Frost

Faculty Publications

Seismic anisotropy in the Earth’s inner core refers to the observation that seismic waves travel faster along the Earth’s rotation axis than in the equatorial plane, a feature inferred from decades of global seismological observations. This directional dependence of wave speeds provides important clues about the structure, composition and dynamics of the inner core. Here we explore a coupled thermo-mechanical mechanism for the generation of inner core anisotropy, focusing on the effects of anisotropic thermal conductivity in iron crystals as the inner core cools. We propose that the higher thermal conductivity of iron along the crystallographic c-axis compared with …

Impediments To Transforming The Healthcare Delivery System: Shifting The Paradigm From Provider Centric To Patient Centric, Elizabeth A. Regan, Manasa Devi Chinta

Faculty Publications

Introduction: 

Stated aims for digital healthcare transformation frequently cite goals for better coordinated patient-centric systems. However, despite advances in medical science, digital technologies, health policies, and billions of dollars invested over the past 25 years, most healthcare providers are far from fully realizing the demonstrated benefits of today's digital technologies for improving patient care. Sharing information across healthcare systems remains challenging. Problems with fragmentation, quality, inequities, and rising costs of care delivery persist. A recent study of 1,026 U.S. hospital systems found that only 15.8 percent achieved a digital maturity level needed to provide digitally enabled healthcare services to better …

Korean Words In The Oed: Race, Gender, And The Modern English Speaker, Elaine W. Chun

Faculty Publications

This article examines representations of the Modern English Speaker of Korean (MESK) in the Oxford English Dictionary (OED), as lexicographers listened to and documented the language of this figure over the past century. I show that, until the early twenty-first century, the most salient type of MESK was the Koreanist, a white, masculine expert on and translator of Korean, the language of a racial other. By contrast, more recent Korean entries, influenced by the global spread of hallyu, have invoked the Korea Fan, a figure that potentially unsettles longstanding ideologies of language, race, and gender. I …

Complex Spin Structure In Co-Trimer-Chain Li2Co3Se4O12, Jie Xing, Feng Ye, Daniel Duong, Sai Mu, Max T. Pan, Rongying Jin

Faculty Publications

Complex magnetic materials are extremely attractive for revealing unconventional spin states and novel magnetic excitations. Here, we report the structural, thermodynamic, and magnetic properties of a novel magnetic material Li₂Co₃Se₄O₁₂based on x-ray and neutron diffraction, specific heat, magnetization, and x-ray photoelectron spectroscopy measurements. X-ray and neutron diffraction refinements reveal two Co sites Co (1) and Co (2) even though both are in the octahedral environment. While they are not connected along the b and c directions, these octahedra are edge-shared forming the Co (2) – Co (1) – Co (2) trimer chain …

Ecology And Life History Of Baleen Whales Inform Climate Change Vulnerabilities And Priorities For Future Monitoring, Lesley H. Thorne, Erin L. Meyer-Gutbrod

Faculty Publications

Baleen whales are key consumers in marine habitats that serve as vectors of nutrients, but their populations have been slow to recover from past commercial whaling due to their low reproductive rates and ongoing anthropogenic threats. Climate impacts have become central to the demography and habitat use of baleen whales, and conservation efforts must account for these impacts to be effective. However, knowledge of baleen whale climate responses is lacking, and current survey effort is insufficient to capture changes in migration and habitat use for many species. Due to their unique combination of ecological and life history characteristics, baleen whales …

Does Genetic Testing Influence Outcomes: Early Experience In Melanoma Case Series, Ryan Reyes, George Skenteris, Stella Coker Watson Self Ph.D., Ms, Christine Marie-Gilligan Schammel, Steven D. Trocha

Faculty Publications

Background:

The treatment and prognosis of melanoma have historically been based on histologic stage and Breslow depth; however, due to the increase in surveillance, melanomas are being identified at an earlier stage and lower Breslow depth. Advances in genetic testing, such as Decision Dx®, mean that melanoma diagnostic decisions and prognosis can now be directed by genetics. The purpose of this project was to assess the influence of a Decision Dx® high-grade (Class 2A/B) classification on the treatment of melanoma patients at a regional medical center, particularly those not deemed high risk by conventional classification methods, including Breslow depth and …

Transfer Learning Neural Networks For Nuclear Forensic Image Morphology Using Image Splitting Techniques, Niko A. Petrocelli, Lee C. Lambert, Brett J. Borghetti, Abigail A. Bickley

Faculty Publications

Manual morphological analysis of actinide particles from scanning electron microscope (SEM) imagery is a critical component of nuclear forensics but is prone to significant inter-analyst variability. To address this challenge, this work develops and evaluates an automated classification method using deep learning. We introduce a methodology based on partitioning 1906 SEM images, representing 13 classes of uranium compounds, into smaller patches for analysis. Three convolutional neural network (CNN) architectures of increasing complexity were compared: a custom baseline CNN, a simple transfer learning model using ResNet50v1, and a complex model featuring hierarchical feature extraction and a spatial attention mechanism built upon …

Dynamic Magnetic Null Behavior In Planar Ion Diodes: Particle-In-Cell Analysis Of Field Oscillations And Ion Beam Dynamics, Jesse C. Foster, Stephen B. Swanekamp, Paul F. Ottinger

Faculty Publications

Particle-in-cell simulations of a 1.75 MV, 375 kA, and 50 ns planar pinched-beam diode reveal that the strongest gigahertz-frequency oscillations in electric field and ion current arise from the dynamic motion of the magnetic null near the anode tip. These oscillations, which appear when the ion transit time becomes comparable to the local field-variation timescale, periodically expand the effective anode–cathode gap and generate bursts of over-accelerated ions. The resulting ion energy spectrum broadens substantially near the null while maintaining excellent beam uniformity along the anode. The simulations, therefore, demonstrate a direct physical linkage between ion transit time instability and magnetic …

Experiments Towards A Neutron Target For Measurements In Inverse Kinematics, S. F. Dellmann, Caroline M. Harrington, O. R. Cantrell, A. L. Cooper, A. Couture, D, V, Gorelov, I Knapová, S. M. Mosby, R. Reifarth, A. Alvarez, A. Aprahamian, J. Butz, I. J. Bos, Michael T. Febbraro, T. Hankins, B. M. Harvey, T. Heftrich, M. Le, Juan J. Manfredi, A. B. Mcintosh, K. V. Manukyan, M. Matney, S. Regener, D. Robertson, A. Simon, D. Sokolovic, E. Stech, G. Tabacaru, W. Tan, M. Wiescher, S. Yennello

Faculty Publications

Neutron-induced reactions play an important role in fundamental nuclear physics, nuclear astrophysics, and applications. In the case of reactions on rare isotopes, there are limited options for direct experimental measurements. The Neutron Target Demonstrator project at Los Alamos National Laboratory seeks to test the feasibility of moderating spallation neutrons within a 1 m³graphite cube to create a standing neutron target for neutron-induced reaction measurements in inverse kinematics. This paper presents the results of experimental neutron flux distribution tests using neutron sources (ranging from 1 keV to 50 MeV) created by accelerators at the University of Notre Dame and …

Exosome Engineering For Blocking Gut Dysbiosis And Inducing Cell Death Mechanisms In Glioblastoma Multiforme, Ahalya Muraleedharan, Karthik Rangavajhula, Swapan K. Ray

Faculty Publications

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor in adults. Emerging evidence endorses that gut dysbiosis contributes to GBM progression through the gut–brain axis (GBA), promoting inflammation and therapeutic resistance via abnormal short-chain fatty acid production and cytokine dysregulation. Exosomes, naturally occurring nanovesicles (30–150 nm), offer promising therapeutic potential due to their blood–brain barrier permeability, biocompatibility, and versatile cargo capacity. This review examines exosome engineering strategies for dual targeting: inhibiting alterations in gut microbiome and inducing regulated cell death mechanisms such as apoptosis and ferroptosis in GBM. We describe exosome engineering with detailed focus on cargo loading approaches …

Egain Tube Memristors Offering Reliable Switching On A Biological Time Scale, Yuriy V. Pershin, Liya Patel, Bapi Bera, Doug Aaron, Stephen A. Sarles

Faculty Publications

Memristive devices have been considered promising candidates for nature-inspired computing and in-memory information processing. However, experimental devices developed to date typically show significant variability and function at different time scales than biological neurons and synapses. This study presents a memristive device comprised of liquid-metal eutectic gallium indium (EGaIn) contained within a mm-scale tube that operates via a bulk, voltage-dependent switching mechanism and exhibits distinct unipolar resistive switching characteristics that occur on a biological time scale (tens of milliseconds). The switching mechanism involves voltage-controlled growth and dissolution of an oxide layer on the surface of the liquid metal in contact with …