Digital Commons Network^™

Patterns Of Hiv Disclosure And Its Impact On The Hiv Care Continuum Among Black Men Who Have Sex With Men In South Carolina, Xueying Yang Ph.D., Titilayo A. James, Monique J. Brown Ph.D., Mph, Tony Brown, Sydney Zarsadias, Ran Zhang, Fanghui Shi, Xiaoming Li Ph.D.

Faculty Publications

Addressing the psychosocial concerns of Black men who have sex with men (MSM), such as HIV disclosure, is critical for effective HIV treatment efforts. Black MSM living with HIV experience multiple psychosocial challenges, such as “triple stigma” due to their sexual orientation, racial minority status, and HIV status, which hinder their HIV disclosure and subsequent HIV care-seeking behavior. Our study sought to examine the HIV disclosure patterns and their impact on the HIV care continuum among Black MSM using a qualitative approach. Semi-structured interviews were carried out among 28 Black MSM aged ≥18 years old living in South Carolina. A …

Protocol For Developing A Personalised Prediction Model For Viral Suppression Among Under-Represented Populations In The Context Of The Covid-19 Pandemic, Jiajia Zhang Ph.D., Xueying Yang Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Bankole Olatosi Ph.D.

Faculty Publications

Introduction Sustained viral suppression, an indicator of long-term treatment success and mortality reduction, is one of four strategic areas of the 'Ending the HIV Epidemic' federal campaign launched in 2019. Under-represented populations, like racial or ethnic minority populations, sexual and gender minority groups, and socioeconomically disadvantaged populations, are disproportionately affected by HIV and experience a more striking virological failure. The COVID-19 pandemic might magnify the risk of incomplete viral suppression among under-represented people living with HIV (PLWH) due to interruptions in healthcare access and other worsened socioeconomic and environmental conditions. However, biomedical research rarely includes under-represented populations, resulting in biased …

Mathematics Library News, Aaron Lercher

Faculty Publications

Mathematics Library News is an LSU Libraries newsletter for members of the Mathematics and Experimental Statistics Departments, published roughly once each semester.

Networks In Motion: The Alliances Of Information Communication Technologies And Mobility Technologies During The 1918 Influenza Pandemic, Miles C. Coleman, Will Mari

Faculty Publications

In this article, we turn back to the 1918 influenza pandemic to throw light on the alliances of information communication technologies and technologies of mobility (such as the car) during the pandemic. We examine newspaper articles, technical publications, and other historical texts to demonstrate that, despite the fact that mobile technologies—such as cellular phones—did not exist during the 1918 pandemic, the telephone and mobility technology nonetheless formed alliances as networks in motion, or social moments in which risk and reward are calculated not simply by the ability to move, but rather the ability to move, while remaining connected, revealing insight …

Covid-19 Challenges, Responses, And Resilience Among Rural Black Women: A Study Protocol, Fanghui Shi, Jiajia Zhang Ph.D., Chengbo Zeng, Xiaowen Sun, Zhenlong Li, Xueying Yang, Sharon Weissman, Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Background

Timely linkage to care (LTC) is key in the HIV care continuum, as it enables people newly diagnosed with HIV (PNWH) to benefit from HIV treatment at the earliest stage. Previous studies have found LTC disparities by individual factors, but data are limited beyond the individual level, especially at the county level. This study examined the temporal and geographic variations of county-level LTC status across 46 counties in South Carolina (SC) from 2010 to 2018 and the association of county-level characteristics with LTC status.

Methods

All adults newly diagnosed with HIV from 2010 to 2018 in SC were included …

The Global Fatty Liver Disease-Sustainable Development Goal Country Score For 195 Countries And Territories, Jeffrey V. Lazarus, Hannah Han, Henry E. Mark, Saleh A. Schattenberg, Jörn M. J., Ismaeel Yunusa Ph. D., Et Al.

Faculty Publications

Background & Aims:

Fatty liver disease is highly prevalent, resulting in overarching wellbeing and economic costs. Addressing it requires comprehensive and coordinated multisectoral action. We developed a fatty liver disease-Sustainable Development Goal (SDG) country score to provide insights into country-level preparedness to address fatty liver disease through a whole-of-society lens.

Approach & Results:

We developed two fatty liver disease-SDG score sets. The first included six indicators (child wasting, child overweight, non-communicable disease [NCD] mortality, universal health coverage service coverage index, health worker density, and education attainment), covering 195 countries between 1990-2017. The second included the aforementioned indicators plus an urban …

Optimization Of Host Cell-Compatible, Antimicrobial Peptides Effective Against Biofilms And Clinical Isolates Of Drug-Resistant Bacteria, Jenisha Ghimire, Robert J. Hart, Anabel Soldano, Charles H. Chen, Shantanu Guha, Joseph P. Hoffmann, Kalen M. Hall, Leisheng Sun, Benjamin J. Nelson, Timothy K. Lu, Jay K. Kolls, Mario Rivera, Lisa A. Morici, William C. Wimley

Faculty Publications

Here, we describe the continued synthetic molecular evolution of a lineage of host-compatible antimicrobial peptides (AMP) intended for the treatment of wounds infected with drug-resistant, biofilm-forming bacteria. The peptides tested are variants of an evolved AMP called d-amino acid CONsensus with Glycine Absent (d-CONGA), which has excellent antimicrobial activities in vitro and in vivo. In this newest generation of rational d-CONGA variants, we tested multiple sequence-structure-function hypotheses that had not been tested in previous generations. Many of the peptide variants have lower antibacterial activity against Gram-positive or Gram-negative pathogens, especially variants that have altered hydrophobicity, secondary structure potential, or spatial …

Intensive Care Unit Mortality And Length Of Stay Among Critically Ill Patients With Sepsis Treated With Corticosteroids: A Retrospective Cohort Study, Eric E. Chinaeke, Ismaeel Yunusa Ph.D., Bryan L. Love Pharm. D., Joseph Magagnoli, Claiborne E. Reeder

Faculty Publications

Objectives: Sepsis is a major cause of morbidity and mortality in critically ill patients worldwide, and corticosteroids are commonly used to treat it. However, the evidence supporting the use of corticosteroids in sepsis patients admitted to the intensive care unit (ICU) is of low certainty, with conflicting results reported in previous studies. Thus, we aimed to investigate the potential association between corticosteroid treatment and various outcomes, including 30-day ICU mortality, ICU length of stay (LOS), mechanical ventilation use, new onset of infection, and hyperglycemia in patients diagnosed with sepsis and admitted to the ICU.

Materials and Methods: We conducted …

Evaluation Of Alternative Colony Hybridization Methods For Pathogenic Vibrios, Andrew M. Schwartz, Haley A. Marcotte, Crystal N. Johnson

Faculty Publications

Vibrios, such as Vibrio parahaemolyticus, are naturally occurring halophilic bacteria that are a major cause of foodborne illness. Because of their autochthonous nature, managing vibrio levels in marine and estuarine environments is impossible. Instead, it is crucial to reliably enumerate their abundance to minimize human exposure. One method of achieving this is the direct plating/colony hybridization (DP/CH) method, which has been used to efficiently quantify pathogenic vibrios in oysters and other seafood products. Although successful, the method relies on proprietary resources. We examined alternative approaches, assessed the influence of the reagent suppliers’ source on enumeration accuracy, and made experimental adjustments …

Amino Acid Derivatives Of Chlorin-E6—A Review, Maria Da Graça H. Vicente, Kevin M. Smith

Faculty Publications

Details of the structural elucidation of the clinically useful photodynamic therapy sensitizer NPe6 (15) are presented. NPe6, also designated as Laserphyrin, Talaporfin, and LS-11, is a second-generation photosensitizer derived from chlorophyll-a, currently used in Japan for the treatment of human lung, esophageal, and brain cancers. After the initial misidentification of the structure of this chlorin-e6 aspartic acid conjugate as (13), NMR and other synthetic procedures described herein arrived at the correct structure (15), confirmed using single crystal X-ray crystallography. Interesting new features of chlorin-e6 chemistry (including the intramolecular formation of an anhydride (24)) are reported, allowing chemists to regioselectively conjugate …

Predicting Grocery Store Visits During The Early Outbreak Of Covid-19 With Machine Learning, Ruijie Bian, Pamela Murray-Tuite, Brian Wolshon

Faculty Publications

While non-essential travel was canceled during the coronavirus infectious disease (COVID-19) pandemic, grocery shopping was essential. The objectives of this study were to: 1) examine how grocery store visits changed during the early outbreak of COVID-19, and 2) estimate a model to predict the change of grocery store visits in the future, within the same phase of the pandemic. The study period (February 15–May 31, 2020) covered the outbreak and phase-one re-opening. Six counties/states in the United States were examined. Grocery store visits (in-store or curbside pickup) increased over 20% when the national emergency was declared on March 13 and …

Rise Of The Metaverse's Immersive Virtual Reality Malware And The Man-In-The-Room Attack & Defenses, Martin Vondráček, Ibrahim Baggili, Peter Casey, Mehdi Mekni

Faculty Publications

The allure of the metaverse along with Virtual Reality (VR) technologies and speed at which they are deployed may shift focus away from security and privacy fundamentals. In this work we employ classic exploitation techniques against cutting edge devices to obtain equally novel results. The unique features of the Virtual Reality landscape set the stage for our primary account of a new attack, the Man-in-the-Room (MitR). This attack, realized from a vulnerable social networking application led to both worming and botnet capabilities being adapted for VR with potential critical impacts affecting millions of users. Our work improves the state-of-the-art in …

A Survey Of South Carolina Pharmacists' Readiness To Prescribe Human Immunodeficiency Virus Pre-Exposure Prophylaxis, Charles M. Burns, Kyle Endres, Caroline Derrick, Alexandra Cooper, Patricia Fabel, Nwora Lance Okeke, Divya Ahuja, Amy Corneli, Mehri S. Mckellar

Faculty Publications

Introduction: Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) is largely underutilized in the Southern United States. Given their community presence, pharmacists are well positioned to provide PrEP within rural, Southern regions. However, pharmacists' readiness to prescribe PrEP in these communities remains unknown. Objective: To determine the perceived feasibility and acceptability of prescribing PrEP by pharmacists in South Carolina (SC). Methods: We distributed a 43-question online descriptive survey through the University of South Carolina Kennedy Pharmacy Innovation Center's listserv of licensed SC pharmacists. We assessed pharmacists' comfort, knowledge, and readiness to provide PrEP. Results: A total of 150 pharmacists responded to …

Utilizing The System Engineering Trade Study Analysis Method To Analyze Patient Aeromedical Evacuation, Sara Shaghaghi, Jeremy M. Slagley, Michael E. Miller, Gaiven Varshney

Faculty Publications

The US Air Force has gone through many aeromedical patient isolation transport system designs. The first designs were developed in response to the Ebola outbreak in 2014 and, more recently, the COVID-19 pandemic. The trade study analysis part of the system engineering design method was used to analyze the historic and current aeromedical patient contamination control transport systems. A trade study is a process that evaluates alternatives based upon various “-ilities”, such as reconfigurability, flexibility, durability, cost, and more, and performs a systematic analysis to aid designers in producing a ‘good’ design alternative given the large set of possible solutions. …

A Draft Of The Genome Of The Gulf Coast Tick, Amblyomma Maculatum, Jose M.C. Ribeiro, Natalia J. Bayona-Vásquez, Khemraj Budachetri, Deepak Kumar, Julia Catherine Frederick, Faizan Tahir, Brant C. Faircloth, Travis C. Glenn, Shahid Karim

Faculty Publications

The Gulf Coast tick, Amblyomma maculatum, inhabits the Southeastern states of the USA bordering the Gulf of Mexico, Mexico, and other Central and South American countries. More recently, its U.S. range has extended West to Arizona and Northeast to New York state and Connecticut. It is a vector of Rickettsia parkeri and Hepatozoon americanum. This tick species has become a model to study tick/Rickettsia interactions. To increase our knowledge of the basic biology of A. maculatum we report here a draft genome of this tick and an extensive functional classification of its proteome. The DNA from a single …

Comparative-Effectiveness Of Oral Beta-Lactams And Fluoroquinolones For Stepdown Therapy In Patients With Enterobacterales Bloodstream Infections: A Retrospective Cohort Study, Lauren Bjork Ph.D., Teri Hopkins Ph.D., Linda Yang Ph.D., Chengwen Teng Pharm.D., Ph.D., Xavier Jones Bs, Jose Cadena, Elizabeth Walter, Christopher R. Frei Pham.D., Ms

Faculty Publications

Background: This study compares treatment failure for patients who received oral beta-lactams (BLs) and fluoroquinolones (FQs) for stepdown treatment of Enterobacterales bloodstream infections (BSIs).

Methods: We conducted a single-center, retrospective, age- and sex-matched, cohort study, at a Veterans Affairs (VA) hospital in South Texas. Eligible patients were at least 18 years of age with a monomicrobial BSI treated with a single oral BL or FQ antibiotic. Treatment failure was defined as recurrence or all-cause mortality within 90 days of documented BSI. Bivariate (chi-square, Fisher's Exact, and Wilcoxon Rank Sum) and multivariate (logistic regression) statistical tests were used to compare groups. …

Ancient Pathogens Provide A Window Into Health And Well-Being, Cecil M. Lewis Jr., Mercy Y. Akinyi, Sharon Dewitte, Anne C. Stone

Faculty Publications

This perspective draws on the record of ancient pathogen genomes and microbiomes illuminating patterns of infectious disease over the course of the Holocene in order to address the following question. How did major changes in living circumstances involving the transition to and intensification of farming alter pathogens and their distributions? Answers to this question via ancient DNA research provide a rapidly expanding picture of pathogen evolution and in concert with archaeological and historical data, give a temporal and behavioral context for heath in the past that is relevant for challenges facing the world today, including the rise of novel pathogens.

On Limitations Of Uniplex Networks For Modeling Multiplex Contagion, Nicholas W. Landry, Jimi Adams

Faculty Publications

Many network contagion processes are inherently multiplex in nature, yet are often reduced to processes on uniplex networks in analytic practice. We therefore examine how data modeling choices can affect the predictions of contagion processes. We demonstrate that multiplex contagion processes are not simply the union of contagion processes over their constituent uniplex networks. We use multiplex network data from two different contexts- (1) a behavioral network to represent their potential for infectious disease transmission using a "simple"epidemiological model, and (2) users from online social network sites to represent their potential for information spread using a threshold-based "complex"contagion process. Our …

Antibody-Dependent Enhancement Activity Of A Plant-Made Vaccine Against West Nile Virus, Haiyan Sun, Dhiraj Acharya, Amber M. Paul, Huafang Lai, Junyun He, Fengwei Bai, Qiang Chen

Faculty Publications

West Nile virus (WNV) causes annual outbreaks globally and is the leading cause of mosquito-borne disease in Unite States. In the absence of licensed therapeutics, there is an urgent need to develop effective and safe human vaccines against WNV. One of the major safety concerns for WNV vaccine development is the risk of increasing infection by related flaviviruses in vaccinated subjects via antibody-dependent enhancement of infection (ADE). Herein, we report the development of a plant-based vaccine candidate that provides protective immunity against a lethal WNV challenge mice, while minimizes the risk of ADE for infection by Zika (ZIKV) and dengue …

Moderation Effect Of Community Health On The Relationship Between Racial/Ethnic Residential Segregation And Hiv Viral Suppression In South Carolina: A County-Level Longitudinal Study From 2013 To 2018, Fanghui Shi, Jiajia Zhang Ph.D., Xueying Yang Ph.D., Xiaowen Sun, Zhenlong Li, Chengbo Zeng, Huan Ning, Sharon Weissman, Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Background: Viral suppression is the ultimate goal of the HIV treatment cascade and a primary endpoint of antiretroviral therapy. Empirical evidence found racial/ethnic disparities in viral suppression among people living with HIV (PWH), but the evidence of the relationship between racial/ethnic residential segregation and place-based viral suppression is scarce. Further exploring potential structural moderators in this relationship has substantial implications for healthcare policymaking and resource allocation. The current study aimed to investigate the spatial-temporal disparities in the HIV viral suppression rate across 46 counties in South Carolina from 2013 to 2018. We also examined the impact of racial/ethnic residential segregation …

Engineering At-Home Dilution And Filtration Methods To Enable Paper-Based Colorimetric Biosensing In Human Blood With Cell-Free Protein Synthesis, Tyler J. Free, Ryan W. Tucker, Katelyn M. Simonson, Sydney A. Smith, Caleb M. Lindgren, William G. Pitt, Bradley C. Bundy

Faculty Publications

Diagnostic blood tests can guide the administration of healthcare to save and improve lives. Most clinical biosensing blood tests require a trained technician and specialized equipment to process samples and interpret results, which greatly limits test accessibility. Colorimetric paper-based diagnostics have an equipment-free readout, but raw blood obscures a colorimetric response which has motivated diverse efforts to develop blood sample processing techniques. This work uses inexpensive readily-available materials to engineer user-friendly dilution and filtration methods for blood sample collection and processing to enable a proof-of-concept colorimetric biosensor that is responsive to glutamine in 50 µL blood drop samples in less …

Data Visualization Of Big Data For Predictive And Descriptive Analytics For Stroke, Covid-19, And Diabetes, Richard S. Segall, Soichiro Takashashi

Faculty Publications

Visualization of big data is crucial for meaningful interpretations and especially for healthcare. Brief discussions are made for big data, background for healthcare, and recent work in big data analytics for healthcare. This research pertains to different levels of big data: 5,110 vs. 101,766 vs. 320,200 vs. 1 million data values. Data visualizations and predictive analytics are presented of big data for selected diseases of stroke with 5,110 data values, diabetes with 101,766 data values, and two COVID-19 studies: one with 320,200 data values and another with 1 million data values. Data visualizations are generated for these diseases with big …

Identification Of Oral Therapeutics Using An Ai Platform Against The Virus Responsible For Covid-19, Sars-Cov-2, Adam Bess, Frej Berglind, Supratik Mukhopadhyay, Michal Brylinski, Chris Alvin, Fanan Fattah, Kishor M. Wasan

Faculty Publications

Purpose: This study introduces a sophisticated computational pipeline, eVir, designed for the discovery of antiviral drugs based on their interactions within the human protein network. There is a pressing need for cost-effective therapeutics for infectious diseases (e.g., COVID-19), particularly in resource-limited countries. Therefore, our team devised an Artificial Intelligence (AI) system to explore repurposing opportunities for currently used oral therapies. The eVir system operates by identifying pharmaceutical compounds that mirror the effects of antiviral peptides (AVPs)—fragments of human proteins known to interfere with fundamental phases of the viral life cycle: entry, fusion, and replication. eVir extrapolates the probable antiviral efficacy …

Reconsidering The Good Of Improving Accountability, Roy L. Heidelberg

Faculty Publications

Among the rhetorical pleas that follow most instances of public dissatisfaction is the call for more or better accountability. Accountability is a lauded notion, a “golden concept” that is considered widely as critical to the success of democratic government. Such pleas, I will argue, are misplaced. Rather than starting from the premise of accountability as an idea that no one can be against, I consider the possibility that accountability undermines the very notion it ostensibly promotes: self-government. The concept of accountability in modern political theory is tied more closely to the emergence of an impersonal administrative state than it is …

Show Us The Data: Global Covid-19 Wastewater Monitoring Efforts, Equity, And Gaps, Colleen C. Naughton, Fernando A. Roman, Ana Grace F. Alvarado, Arianna Q. Tariqi, Matthew A. Deeming, Krystin F. Kadonsky, Kyle Bibby, Aaron Bivins, Gertjan Medema, Warish Ahmed, Panagis Katsivelis, Vajra Allan, Ryan Sinclair, Joan B. Rose

Faculty Publications

A year since the declaration of the global coronavirus disease 2019 (COVID-19) pandemic, there were over 110 million cases and 2.5 million deaths. Learning from methods to track community spread of other viruses such as poliovirus, environmental virologists and those in the wastewater-based epidemiology (WBE) field quickly adapted their existing methods to detect SARS-CoV-2 RNA in wastewater. Unlike COVID-19 case and mortality data, there was not a global dashboard to track wastewater monitoring of SARS-CoV-2 RNA worldwide. This study provides a 1-year review of the “COVIDPoops19” global dashboard of universities, sites, and countries monitoring SARS-CoV-2 RNA in wastewater. Methods to …

Aircraft Wastewater Surveillance For Early Detection Of Sars-Cov-2 Variants — John F. Kennedy International Airport, New York City, August–September 2022, Robert C. Morfino, Stephen M. Bart, Andrew Franklin, Benjamin H. Rome, Andrew P. Rothstein, Thomas W.S. Aichele, Siyao Lisa Li, Aaron Bivins, Ezra T. Ernst, Cindy R. Friedman

Faculty Publications

No abstract provided.

Residential Segregation And County-Level Covid-19 Booster Coverage In The Deep South: Surveillance Report And Ecological Study, Chengbo Zeng, Jiajia Zhang Ph.D., Zhenlong Li, Xiaowen Sun, Huan Ning, Xueying Yang, Sharon Weissman, Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Background: COVID-19 had a greater impact in the Deep South compared with other regions in the United States. While vaccination remains a top priority for all eligible individuals, data regarding the progress of booster coverage in the Deep South and how the coverage varies by county and age are sparse. Despite existing evidence of racial and ethnic disparities in COVID-19 vaccinations at the individual level, there is an urgent need for evidence at the population level. Such information could highlight vulnerable communities and guide future health care policy-making and resource allocation.

Objective: We aimed to evaluate county-level COVID-19 booster coverage …

Using Geospatial Social Media Data For Infectious Disease Studies: A Systematic Review, Fengrui Jing, Zhenlong Li, Shan Qiao Ph.D., Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Geospatial social media (GSM) data has been increasingly used in public health due to its rich, timely, and accessible spatial information, particularly in infectious disease research. This review synthesized 86 research articles that use GSM data in infectious diseases published between December 2013 and March 2022. These articles cover 12 infectious disease types ranging from respiratory infectious diseases to sexually transmitted diseases with spatial levels varying from the neighborhood, county, state, and country. We categorized these studies into three major infectious disease research domains: surveillance, explanation, and prediction. With the assistance of advanced computing, statistical and spatial methods, GSM data …

Ecologic Analysis Of Antimicrobial Use In South Carolina Hospitals During 2020–2022, Pamela Bailey, Shujie Chen, Majdi N. Al-Hasan, Bankole Olatosi Ph.D., Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Background:

Factors influencing excessive antimicrobial utilization in hospitalized patients remain poorly understood, particularly with the COVID-19 pandemic.

Methods:

In this retrospective cohort, we compared administrative data regarding antimicrobial prescriptions in hospitalized patients in South Carolina from March 2020 through September 2022. The study examined variables associated with antimicrobial use across demographics, COVID status, and length of stay, among other variables.

Results:

Significant relationships were seen with antimicrobial use in COVID-19 positive patients (OR 2.00, 95% Confidence Interval (CI): 1.9–2.1), young adults (OR 1.08, 95% CI: 0.99–1.12, COVID-19 positive Blacks and Hispanics (OR 1.06, 95% CI: 1.01–1.11, OR 1.05, 95% CI: …

Physicians Spreading Medical Misinformation: The Uneasy Case For Regulation, Richard S. Saver

Faculty Publications

Physicians have played a surprisingly prominent role in the current “infodemic” of false and misleading medical claims. Yet, state medical boards, the governmental agencies responsible for professional licensure and oversight, have sanctioned remarkably few physicians. Pushing back against the widespread criticism of medical boards for insufficient action, this Article questions the overall suitability of licensure regulation to police medical misinformation. First, uncertainty exists about medical boards’ jurisdiction and legal authority. Many misinformation claims have involved physicians communicating publicly, not while treating patients. Given the primarily patient-centered legal and ethical frameworks governing the practice of medicine, serious challenges arise in making …