Digital Commons Network^™

Intracellular Targeting Specificity Of Novel Phthalocyanines Assessed In A Host-Parasite Model For Developing Potential Photodynamic Medicine, Sujoy Dutta, Benson G. Ongarora, Hairong Li, Maria Graca H. Da Vicente, Bala K. Kolli, Kwang Poo Chang

Faculty Publications

Photodynamic therapy, unlikely to elicit drug-resistance, deserves attention as a strategy to counter this outstanding problem common to the chemotherapy of all diseases. Previously, we have broadened the applicability of this modality to photodynamic vaccination by exploiting the unusual properties of the trypanosomatid protozoa, Leishmania, i.e., their innate ability of homing to the phagolysosomes of the antigen-presenting cells and their selective photolysis therein, using transgenic mutants endogenously inducible for porphyrin accumulation. Here, we extended the utility of this host-parasite model for in vitro photodynamic therapy and vaccination by exploring exogenously supplied photosensitizers. Seventeen novel phthalocyanines (Pcs) were screened in vitro …

Code Simulations And Death: Processing Of Emotional Distress, Jane D. Leavy, Calvin J. Vanderhoff, Patricia K. Ravert

Faculty Publications

It is important for nursing students to be exposed to critical patient care scenarios because high stress clinical situations, such as patient codes, occur unexpectedly and infrequently in the clinical setting. In addition, it is important for nursing students to be exposed to the reality of patient death in order to help them overcome fears associated with death and to develop effective coping strategies. Students may or may not have an opportunity to deal with patient codes or patient death in the clinical setting, therefore simulation labs provide students with the opportunity to practice important clinical skills and discuss emotions …

Librarians As Partners Of The Nursing Faculty In Teaching Scholarly Inquiry In Nursing To Undergraduates At Brigham Young University, Jane Lassetter, Barbara L. Mandleco, Lynn C. Callister, Elizabeth S. Hopkins, Meagan Astill

Faculty Publications

This paper describes collaboration between the nursing librarian and faculty members teaching Scholarly Inquiry in Nursing (Nursing Research), a course for baccalaureate nursing students. Workshops presented by the librarian enhanced nursing students' information literacy skills, particularly related to accessing evidence-based sources. Student perceptions of the library integration with Scholarly Inquiry in Nursing are presented, and suggest that librarians empower them with knowledge and skills that enhance their ability to integrate evidence into their nursing practice.

Hef1, A Novel Target Of Wnt Signaling, Promotes Colonic Cell Migration And Cancer Progression, Y. Li, J. H. Bavarva, Z. Wang, J. Guo, C. Qian, S. N. Thibodeau, E. A. Golemis, W. Liu

Faculty Publications

Misregulation of the canonical Wnt/Β-catenin pathway and aberrant activation of Wnt signaling target genes are common in colorectal cancer (CRC) and contribute to cancer progression. Altered expression of human enhancer of filamentation 1 (HEF1; also known as NEDD9 or Cas-L) has been implicated in progression of melanoma, breast, and CRC. However, the regulation of HEF1 and the role of HEF1 in CRC tumorigenesis are not fully understood. We here identify HEF1 as a novel Wnt signaling target. The expression of HEF1 was upregulated by Wnt-3a, Β-catenin, and Dvl2 in a dose-dependent manner, and was suppressed following Β-catenin downregulation by shRNA. …

A Theoretical Model Of Multi-Agent Quantum Computing, F. Matthew Mihelic

Faculty Publications

The best design for practical quantum computing is one that emulates the multi-agent quantum logic function of natural biological systems. Such systems are theorized to be based upon a quantum gate formed by a nucleic acid Szilard engine (NASE) that converts Shannon entropy of encountered molecules into useful work of nucleic acid geometric reconfiguration. This theoretical mechanism is logically and thermodynamically reversible in this special case because it is literally constructed out of the (nucleic acid) information necessary for its function, thereby allowing the nucleic acid Szilard engine to function reversibly because, since the information by which it functions exists …

The Community Narration (Cn) Approach: Understanding A Group’S Identity And Cognitive Constructs Through Personal And Community Narratives, Brad Olson, Leonard A. Jason

Faculty Publications

Community program evaluations, visioning and assessments must always endeavor to attain useful information in the most sensitive way. Most community-based organizations form, grow and continue on their own without the help of outside experts. Participatory approaches should respect the historical evolution of these groups and understand the positive factors that underlie their organizational beliefs. A group’s mission, values and identity should inform any community program evaluation, consulting project, and the design of any research study. Narrative methods have been used with mutual-help groups and many other organizations to good effect (Harré, Bullen, & Olson, 2006; Rappaport, 2000). Such methods have …

Individual Taxation: Digest Of Recent Developments, Ellen Cook, Edward A. Gershman, Janet Hagy, Jonathan Horn, Daniel T. Moore, Annette Nellen, Kenneth L. Rubin

Faculty Publications

The Tax Relief, Unemployment Insurance Reauthorization, and Job Creation Act of 2010 extended the current individual income tax rates on ordinary income and the rates on qualified dividend and capital gains income for two years through 2012. * The IRS, changing its long-standing position, ruled that debt on a mortgage loan used to acquire, construct, or substantially improve a qualified residence, to the extent it exceeds $1 million, qualifies as home equity indebtedness, and thus the interest on up to $100,000 of that debt is deductible as an itemized deduction. * The Tax Court held that the Sec. 121 exclusion …

Caloric Restriction, Aerobic Exercise Training And Soluble Lectin-Like Oxidized Ldl Receptor-1 Levels In Overweight And Obese Post-Menopausal Women, Tina E. Brinkley, Xuewen Wang, Noriaki Kume, Hirokazu Mitsuoka, Barbara J. Nicklas

Faculty Publications

Background—Elevated circulating levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) have been observed in obese persons and are reduced by weight loss. However, it is not known if combining caloric restriction (CR) with exercise training is better in reducing sLOX-1 levels than CR alone.

Objective—We examined whether the addition of aerobic exercise to a weight loss intervention differentially affects sLOX-1 levels in 61 abdominally obese postmenopausal women randomly assigned to a CR only (n=22), CR + moderate-intensity exercise (n=22), or CR + vigorous intensity exercise (n=17) intervention for 20 weeks. The caloric deficit was ~2,800 kcal/week for …

Iron-Sulfur Proteins Are The Major Source Of Protein-Bound Dinitrosyl Iron Complexes Formed In Escherichia Coli Cells Under Nitric Oxide Stress, Aaron P. Landry, Xuewu Duan, Hao Huang, Huangen Ding

Faculty Publications

Protein-bound dinitrosyl iron complexes (DNICs) have been observed in prokaryotic and eukaryotic cells under nitric oxide (NO) stress. The identity of proteins that bind DNICs, however, still remains elusive. Here we demonstrate that iron-sulfur proteins are the major source of protein-bound DNICs formed in Escherichia coli cells under NO stress. Expression of recombinant iron-sulfur proteins, but not proteins without iron-sulfur clusters, almost doubles the amount of protein-bound DNICs formed in E. coli cells after NO exposure. Purification of recombinant proteins from the NO-exposed E. coli cells further confirms that iron-sulfur proteins, but not proteins without iron-sulfur clusters, are modified, forming …

Branchless Trichomes Links Cell Shape And Cell Cycle Control In Arabidopsis Trichomes, Remmy Kasili, Cho Chun Huang, Jason D. Walker, L. Alice Simmons, Jing Zhou, Chris Faulk, Martin Hülskamp, John C. Larkin

Faculty Publications

Endoreplication, also called endoreduplication, is a modified cell cycle in which DNA is repeatedly replicated without subsequent cell division. Endoreplication is often associated with increased cell size and specialized cell shapes, but the mechanism coordinating DNA content with shape and size remains obscure. Here we identify the product of the BRANCHLESS TRICHOMES (BLT) gene, a protein of hitherto unknown function that has been conserved throughout angiosperm evolution, as a link in coordinating cell shape and nuclear DNA content in endoreplicated Arabidopsis trichomes. Loss-of-function mutations in BLT were found to enhance the multicellular trichome phenotype of mutants in the SIAMESE (SIM) …

Reading Te Leaves: New Approaches To The Identification Of Transposable Element Insertions, David A. Ray, Mark A. Batzer

Faculty Publications

Transposable elements (TEs) are a tremendous source of genome instability and genetic variation. Of particular interest to investigators of human biology and human evolution are retrotransposon insertions that are recent and/or polymorphic in the human population. As a consequence, the ability to assay large numbers of polymorphic TEs in a given genome is valuable. Five recent manuscripts each propose methods to scan whole human genomes to identify, map, and, in some cases, genotype polymorphic retrotransposon insertions in multiple human genomes simultaneously. These technologies promise to revolutionize our ability to analyze human genomes for TE-based variation important to studies of human …

Host Specificity Of Anthonomus Tenebrosus (Coleoptera: Curculionidae), A Potential Biological Control Agent Of Tropical Soda Apple (Solanaceae) In Florida, J. Medal, N. Bustamante, E. Bredow, H. Pedrosa, W. Overholt, R. Díaz, J. Cuda

Faculty Publications

Multiple-choice and no-choice tests were conducted at the Florida Department of Agriculture quarantine facility to determine the host specificity of the South American flower bud weevil, Anthonomus tenebrosus Boheman, intended for biological control of the exotic weed tropical soda apple (TSA), Solanum viarum Dunal in Florida, USA. Ninety-one plant species in 21 families were included in multiple-choice feeding and oviposition experiments, including the target weed and the 6 major cultivated Solanaceae: bell pepper (Capsicum annuum L.), chili pepper (C. frutescens L.), tomato (Lycopersicon esculentum Mill.), tobacco (Nicotiana tabacum L.), eggplant (Solanum melongena L.), and potato (Solanum tuberosum L.). Plant bouquets …

Evaluation Of Juvenile Hormone Analogues As Rodent Feed-Through Insecticides For Control Of Immature Phlebotomine Sandflies, T. M. Mascari, M. A. Mitchell, E. D. Rowton, L. D. Foil

Faculty Publications

The juvenile hormone analogues methoprene and pyriproxyfen were evaluated as rodent feed-through insecticides for control of immature stages of the sandfly Phlebotomus papatasi Scopoli (Diptera: Psychodidae). The development and survival of P. papatasi second-instar larvae fed faeces from Syrian hamsters, Mesocricetus auratus, that had been fed a diet containing methoprene (0, 9.788, 97.88 or 978.8 p.p.m.) or pyriproxyfen (0, 9.82, 98.2 or 982 p.p.m.) were evaluated. The faeces of methoprene-treated hamsters greatly reduced the percentage of larvae that pupated at all concentrations tested and prevented adult emergence at all but the lowest concentration (9.788 p.p.m.). Pyriproxyfen prevented both pupation and …

Hub City Steps: Methods And Early Findings From A Community-Based Participatory Research Trial To Reduce Blood Pressure Among African Americans, Jamie M. Zoellner, Carol L. Connell, Michael B. Madson, Bo Wang, Vickie Blakely Reed, Elaine F. Molaison, M. Kathleen Yadrick

Faculty Publications

Background: Community-based participatory research (CBPR) has been recognized as an important approach to develop and execute health interventions among marginalized populations, and a key strategy to translate research into practice to help reduce health disparities. Despite growing interest in the CBPR approach, CBPR initiatives rarely use experimental or other rigorous research designs to evaluate health outcomes. This behavioral study describes the conceptual frameworks, methods, and early findings related to the reach, adoption, implementation, and effectiveness on primary blood pressure outcomes.

Methods: The CBPR, social support, and motivational interviewing frameworks are applied to test treatment effects of a two-phased CBPR walking …

The Effects On Population Health Status Of Using Dedicated Property Taxes To Fund Local Public Health Agencies, Peggy A. Honoré, Xueyuan Wang

Faculty Publications

Background: In the United States, a dedicated property tax describes the legal authority given to a local jurisdiction to levy and collect a tax for a specific purpose. We investigated for an association of locally dedicated property taxes to fund local public health agencies and improved health status in the eight states designated as the Mississippi Delta Region.

Methods: We analyzed the difference in health outcomes of counties with and without a dedicated public health tax after adjusting for a set of control variables using regression models for county level data from 720 counties of the Mississippi Delta …

Differential Gene Expression Of Foxo1, Id1, And Id3 Between Young And Older Men And Associations With Muscle Mass And Function, Thomas W. Buford, Matthew B. Cooke, Brian D. Shelmadine, Geoffrey M. Hudson, Liz L. Redd, Darryn S. Willoughby

Faculty Publications

Background and aims: Aging is associated with significant losses of skeletal muscle mass and function. Numerous biochemical molecules have been implicated in the development of these age-related changes, however evidence from human models is sparse. Assessment of transcript expression is useful as it requires minimal tissue and may potentially be used in clinical trials. This study aimed to compare mRNA expression of proteolytic genes in skeletal muscle of young (18–35 yrs) and older (55–75 yrs) men.

Methods: Muscle tissue was obtained from young (n=14, 21.35±01.03 yrs) and older (n=13, 63.85±1.83 yrs) men using percutaneous biopsy, and transcript expression was quantified …

Assessing The Risk Of Second Malignancies After Modern Radiotherapy, Wayne D. Newhauser, Marco Durante

Faculty Publications

Recent advances in radiotherapy have enabled the use of different types of particles, such as protons and heavy ions, as well as refinements to the treatment of tumours with standard sources (photons). However, the risk of second cancers arising in long-term survivors continues to be a problem. The long-term risks from treatments such as particle therapy have not yet been determined and are unlikely to become apparent for many years. Therefore, there is a need to develop risk assessments based on our current knowledge of radiation-induced carcinogenesis. © 2011 Macmillan Publishers Limited. All rights reserved.

Convection Enhanced Delivery Of Carboranylporphyrins For Neutron Capture Therapy Of Brain Tumors, Shinji Kawabata, Weilian Yang, Rolf F. Barth, Gong Wu, Tianyao Huo, Peter J. Binns, Kent J. Riley, Owendi Ongayi, Vijay Gottumukkala, M. Graça H. Vicente

Faculty Publications

Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when non-radioactive 10B is irradiated with low energy thermal neutrons to produce α-particles ( 10B[n,α]7Li). Carboranylporphyrins are a class of substituted porphyrins containing multiple carborane clusters. Three of these compounds, designated H2TBP, H2TCP, and H2DCP, have been evaluated in the present study. The goals were two-fold. First, to determine their biodistribution following intracerebral (i.c.) administration by short term (30 min) convection enhanced delivery (CED) or sustained delivery over 24 h by Alzet™ osmotic pumps to F98 glioma bearing rats. Second, to determine the efficacy …

Developing Resistance To Aflatoxin In Maize And Cottonseed, Jeffrey W. Cary, Kanniah Rajasekaran, Robert L. Brown, Meng Luo, Zhi Yuan Chen, Deepak Bhatnagar

Faculty Publications

At this time, no ''magic bullet'' for solving the aflatoxin contamination problem in maize and cottonseed has been identified, so several strategies must be utilized simultaneously to ensure a healthy crop, free of aflatoxins. The most widely explored strategy for the control of aflatoxin contamination is the development of preharvest host resistance. This is because A. flavus infects and produces aflatoxins in susceptible crops prior to harvest. In maize production, the host resistance strategy has gained prominence because of advances in the identification of natural resistance traits. However, native resistance in maize to aflatoxin contamination is polygenic and complex and, …

Stroke Mortality And Trends From 1990 To 2006 In 39 Countries From Europe And Central Asia: Implications For Control Of High Blood Pressure, Josep Redon, Michael H. Olsen, Richard S. Cooper, Oscar Zurriaga, Miguel A. Martinez-Beneito, Stephane Laurent, Renata Cifkova, Antonio Coca, Guiseppe Mancia

Faculty Publications

AimsThe aim of the present study was to extend our understanding of international trends in stroke and major sequelae in Europe and countries peripheral to Europe by assessing: (1) current mortality rates, (2) the most recent 15-year prevalence trends, and (3) the relationship between systolic blood pressure in community surveys and national stroke mortality. Methods and resultsData were obtained from the World Health Organization (WHO www.who.int/whosis/database/mort/table.cfm), and represent national vital statistics as reported by 39 countries (European and Central Asian countries) using a standard format and population-based cardiovascular surveys. Total numbers of deaths by stroke (International Classification of Diseases 430438, …

Combined Admixture Mapping And Association Analysis Identifies A Novel Blood Pressure Genetic Locus On 5p13: Contributions From The Care Consortium, Xiaofeng Zhu, J. H. Young, Ervin Fox, Brendan J. Keating, Nora Franceschini, Sunjung Kang, Bamidele Tayo, Adebowale Adeyemo, Yun V. Sun, Yali Li, Alanna Morrison, Christopher Newton-Cheh, Kiang Liu, Santhi K. Ganesh, Abdullah Kutlar, Ramachandran S. Vasan, Albert Dreisbach, Sharon Wyatt, Joseph Polak, Walter Palmas, Solomon Musani, Herman Taylor, Richard Fabsitz, Raymond R. Townsend, Daniel Dries, Joseph Glessner, Charleston W.K. Chiang, Thomas Mosley, Sharon Kardia, David Curb, Joel N. Hirschhorn, Charles Rotimi, Alexander Reiner

Faculty Publications

Admixture mapping based on recently admixed populations is a powerful method to detect disease variants with substantial allele frequency differences in ancestral populations. We performed admixture mapping analysis for systolic blood pressure (SBP) and diastolic blood pressure (DBP), followed by trait-marker association analysis, in 6303 unrelated African-American participants of the Candidate Gene Association Resource (CARe) consortium. We identified five genomic regions (P < 0.001) harboring genetic variants contributing to inter-individual BP variation. In follow-up association analyses, correcting for all tests performed in this study, three loci were significantly associated with SBP and one significantly associated with DBP (P < 10-5). Further analyses suggested that six independent single-nucleotide polymorphisms (SNPs) contributed to the phenotypic variation observed in the admixture mapping analysis. These six SNPs were examined for replication in multiple, large, independent studies of African-Americans [Women's Health Initiative (WHI), Maywood, Genetic Epidemiology Network of Arteriopathy (GENOA) and Howard University Family Study (HUFS)] as well as one native African sample (Nigerian study), with a total replication sample size of 11 882. Meta-analysis of the replication set identified a novel variant (rs7726475) on chromosome 5 between the SUB1 and NPR3 genes, as being associated with SBP and DBP (P < 0.0015 for both); in meta-analyses combining the CARe samples with the replication data, we observed P-values of 4.45 × 10-7 for SBP and 7.52 × 10-7 for DBP for rs7726475 that were significant after accounting for all the tests performed. Our study highlights that admixture mapping analysis can help identify genetic variants missed by genomewide association studies because of drastically reduced number of tests in the whole genome. © The Author 2011. Published by Oxford University Press.

Association Of Genetic Variation With Systolic And Diastolic Blood Pressure Among African Americans: The Candidate Gene Association Resource Study, Ervin R. Fox, J. Hunter Young, Yali Li, Albert W. Dreisbach, Brendan J. Keating, Solomon K. Musani, Kiang Liu, Alanna C. Morrison, Santhi Ganesh, Abdullah Kutlar, Vasan S. Ramachandran, Josef F. Polak, Richard R. Fabsitz, Daniel L. Dries, Deborah N. Farlow, Susan Redline, Adebowale Adeyemo, Joel N. Hirschorn, Yan V. Sun, Sharon B. Wyatt, Alan D. Penman, Walter Palmas, Jerome I. Rotter, Raymond R. Townsend, Ayo P. Doumatey, Bamidele O. Tayo, Thomas H. Mosley, Helen N. Lyon, Sun J. Kang, Charles N. Rotimi, Richard S. Cooper, Nora Franceschini, J. David Curb

Faculty Publications

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide singlenucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with …

Control Of Reflexive Saccades Following Hemispherectomy, Patricia A. Reuter-Lorenz, Troy M. Herter, Daniel Guitton

Faculty Publications

Individuals who have undergone hemispherectomy for treatment of intractable epilepsy offer a rare and valuable opportunity to examine the ability of a single cortical hemisphere to control oculomotor performance. We used peripheral auditory events to trigger saccades, thereby circumventing dense postsurgical hemianopia. In an antisaccade task, patients generated numerous unintended short-latency saccades toward contralesional auditory events, indicating pronounced limitations in the ability of a single hemicortex to exert normal inhibitory control over ipsilateral (i.e., contralesional) reflexive saccade generation. Despite reflexive errors, patients retained an ability to generate correct antisaccades in both directions. The prosaccade task revealed numerous contralesional express saccades, …

The Influence Of Teacher-Initiated Reminders On The Attainment Of Students' Aerobic Fitness Goals, Ross Chakrain, Jennifer J. Waldron

Faculty Publications

Goal setting in the physical education classroom can be a successful technique to enhance motivation, increase effort, and improve performance. A critical component of effective goal setting is providing feedback. Therefore, the purpose of the current study was to examine the influence of teacher-initiated reminders of the goal on the attainment of self-set aerobic goals in physical education classes. This study was quasi-experimental in nature and used a nonrandomized pretest-posttest, control group design to carry out the procedures. Participants were from two fifth grade classes: one class was designated the experimental group (n = 15) and the other was the …

Henry Wirz And Andersonville: The Career Of The Most Controversial Swiss American, Albert Winkler

Faculty Publications

Henry Wirz is the most controversial Swiss American. He was assigned to oversee the Andersonville Prison during the Civil War, and he was blamed for the high death rate in that prison even though he had no means of getting additional food and supplies to the captives. He was tried for war crimes after the Civil War. He was not allowed an adequate defense at his trial, and he was found guilty in a travesty of justice. He refused an offer of clemency if he would implicate Jefferson Davis and other high Confederate officials in a plot to kill Union …

Exploring Programmatic Moderators Of The Effectiveness Of Marriage And Relationship Education Programs: A Meta-Analytic Study, Alan J. Hawkins, Scott M. Stanley, Victoria L. Blanchard, Michael Albright

Faculty Publications

This study uses meta-analytic methods to explore programatic moderators or common factors of the effectiveness of marriage and relationship education (MRE) programs. We coded 148 evaluation reports for potential programmatic factors that were associated with stronger intervention effects, although the range of factors we could code was limited by the lack of details in the reports. Overall, we found a positive effect for program dosage: moderate-dosage programs (9–20 contact hours) were associated with stronger effects compared to low-dosage programs (1–8 contact hours). A programmatic emphasis on communication skills was associated with stronger effects on couple communication outcomes, but this difference …

Planning For Same-Sex Couples In 2011, Patricia A. Cain

Faculty Publications

This article is the published version of a CLE outline prepared for ALI-ABA in January 2011 and then updated in March 2011. It includes citations to relevant authority regarding a number of tax issues that same-sex couples encounter both under the income tax and under the estate and gift tax system. The outline also includes a list of states that recognize the status of same-sex couples as married, registered domestic partners, civil unions, or similar forms of recognition, and identifies those states in which legislative action recognizing same-sex couples is possible and those in which it is not, due to …

Nanomaterials And The Precautionary Principle, Kevin C. Elliott Phd

Faculty Publications

No abstract provided.

Cardiometabolic Results From An Armband-Based Weight Loss Trial, John C. Sieverdes, Xuemei Sui, Gregory A. Hand, Vaughn W. Barry, Sarah Wilcox, Rebecca A. Meriwether, James W. Hardin, Amanda C. Mcclain, Steven N. Blair

Faculty Publications

Purpose: This report examines the blood chemistry and blood pressure (BP) results from the Lifestyle Education for Activity and Nutrition (LEAN) study, a randomized weight loss trial. A primary purpose of the study was to evaluate the effects of real-time self-monitoring of energy balance (using the SenseWear^TM Armband, BodyMedia, Inc Pittsburgh, PA) on these health factors.

Methods: 164 sedentary overweight or obese adults (46.8 ± 10.8 years; BMI 33.3 ± 5.2 kg/m²; 80% women) took part in the 9-month study. Participants were randomized into 4 conditions: a standard care condition with an evidence-based weight loss manual (n …

Benefits, Challenges And Strategies Of Open Access And Repository Implementation In Seventh-Day Adventist University Libraries: An International Perspective, Silas Bruscagin Marques Dr.

Faculty Publications

Open Access and institutional repositories are rapidly making their way into the scientific communication s pipe line. Many universities are implementing their own intellectual production repositories using open access strat egy and technology as a means for maintaining and accessing these archives. With this trend, libraries and researchers have free access to an abundance of subject, institutional and author access points. The literature is becoming robust in presenting the results of research depicting benefits from its use and the challenges libraries face implementing such initiatives. This research investigated 92 university and technological library directors from 66 different countries regarding their …