Digital Commons Network^™

How Many Steps/Day Are Enough? For Adults, Catrine Tudor-Locke, Cora L. Craig, Wendy J. Brown, Stacy A. Clemes, Katrien Decocker, Billie Giles-Corti, Yoshiro Hatano, Shigeru Inoue, Sandra M. Matsudo, Nanette Mutrie, Jean-Michel Oppert, David A. Rowe, Michael D. Schmidt, Grant M. Schofield, John C. Spence, Pedro J. Teixeira, Mark A. Tully, Steven N. Blair

Faculty Publications

Physical activity guidelines from around the world are typically expressed in terms of frequency, duration, and intensity parameters. Objective monitoring using pedometers and accelerometers offers a new opportunity to measure and communicate physical activity in terms of steps/day. Various step-based versions and translations of physical activity guidelines are emerging, reflecting public interest in such guidance. However, there appears to be a wide discrepancy in the exact values that are being communicated. It makes sense that step-based recommendations should be harmonious with existing evidence-based public health guidelines that recognized that "some physical activity is better than none" while maintaining a focus …

How Many Steps/Day Are Enough? For Older Adults And Special Populations, Catrine Tudor-Locke, Cora L. Craig, Yukitoshi Aoyagi, Rhonda C. Bell, Karen A. Croteau, Ilse De Bourdeaudhuij, Ben Ewald, Andrew W. Gardner, Yoshiro Hatano, Lesley D. Lutes, Sandra M. Matsudo, Farah A. Ramirez-Marrero, Laura Q. Rogers, Davod A. Rowe, Michael D. Schmidt, Mark A. Tully, Steven N. Blair

Faculty Publications

Older adults and special populations (living with disability and/or chronic illness that may limit mobility and/or physical endurance) can benefit from practicing a more physically active lifestyle, typically by increasing ambulatory activity. Step counting devices (accelerometers and pedometers) offer an opportunity to monitor daily ambulatory activity; however, an appropriate translation of public health guidelines in terms of steps/day is unknown. Therefore this review was conducted to translate public health recommendations in terms of steps/day. Normative data indicates that 1) healthy older adults average 2,000-9,000 steps/day, and 2) special populations average 1,200-8,800 steps/day. Pedometer-based interventions in older adults and special populations …

Alterations In The Transciptome And Antibiotic Susceptibility Of Staphylococcus Aureus Grown In The Presence Of Diclofenac, James T. Riordan, Joanne M. Dupre, Stephanie A. Cantore-Matyi, Atul Kumar-Singh, Yang Song, Shahrear Zaman, Sonia Horan, Nada S. Helal, Vijayaraj Nagarajan, Mohamed O. Elasri, Brian J. Wilkinson, John E. Gustafson

Faculty Publications

Background

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) which has been shown to increase the susceptibility of various bacteria to antimicrobials and demonstrated to have broad antimicrobial activity. This study describes transcriptome alterations in S. aureus strain COL grown with diclofenac and characterizes the effects of this NSAID on antibiotic susceptibility in laboratory, clinical and diclofenac reduced-susceptibility (Dc^RS) S. aureus strains.

Methods

Transcriptional alterations in response to growth with diclofenac were measured using S. aureus gene expression microarrays and quantitative real-time PCR. Antimicrobial susceptibility was determined by agar diffusion MICs and gradient plate analysis. Ciprofloxacin accumulation was measured …

Mild Traumatic Brain Injury: Are Ed Providers Identifying Which Patients Are At Risk?, Barbara Stuart, Barbara Mandleco, Renea L. Beckstrand, Sondra Heaston

Faculty Publications

Objective: To identify patients with specific ED discharge diagnoses reporting symptoms associated with a mild traumatic brain injury (MTBI), compare frequency/severity of MTBI symptoms by discharge diagnosis, investigate head injury education provided at ED discharge, and learn about changes made by MTBI patients after injury.

Methods: The Post Concussion Symptom Scale, a demographic questionnaire, and open-ended questions about the impact the injury had on patients' lives were completed by 52 ED patients, at least 2 weeks after injury, discharged with concussion/closed head injury, head laceration, motor vehicle crash (MVC), or whiplash/cervical strain diagnoses.

Results: Between 1 and 23 MTBI symptoms …

Racial Differences In The Responses To Shear Stress In Human Umbilical Vein Endothelial Cells, Deborah L. Feairheller, Joon-Young Park, Victor Rizzo, Boa Kim, Michael D. Brown

Faculty Publications

African American ethnicity is an independent risk factor for exaggerated oxidative stress, which is related to inflammation, hypertension, and cardiovascular disease. Recently, we reported that in vitro oxidative stress and inflammation levels differ between African American and Caucasian human umbilical vein endothelial cells (HUVECs), African American HUVECs having higher levels of both. However, it remains to be shown whether the cells would respond differently to external stimuli.

Promoting Couples Collaboration In Type 2 Diabetes: The Diabetes Support Project Pilot Data, Paula Trief, Jonathan G. Sandberg, Robert Ploutz-Snyder, Rebecca Brittain, Donald Cibula, Kasandra Scales, Ruth S. Weinstock

Faculty Publications

A pilot study was conducted to assess the feasibility and potential efficacy of a couples focused diabetes intervention in which a collaborative problem-solving approach to diabetes self-care was promoted. Couples (N = 44), in which one partner had Type 2 diabetes and was in poor blood glucose control were randomly assigned to one of three groups: a couples intervention, and individual intervention, or individual diabetes education. The intervention included goal-setting, dietary behavior change, and a focus on emotions. For those in the couples arm, this was done within the framework of promoting collaborative communication between the partners. All intervention …

Getting To The Root Of Relationship Attributions: Family-Of-Origin Perspectives On Self And Partner Views, Brandt C. Gardner, Dean M. Busby, Brandon K. Burr, Sarah E. Lyon

Faculty Publications

A large body of research has been devoted to the study of family-of-origin (FOO) experience influences on future relationship outcomes and processes. In addition, substantial information exists regarding the role relationship attributions play in connection with relationship quality and stability. Yet, limited information has been forthcoming regarding how the FOO experience has an influence on attributions made in romantic relationships. Structural Equation Modeling (SEM) was employed to assess the impact of the FOO experience on attributions made about one’s own communication and personality variables, as well as the communication and personality variables of one’s partner from a sample of individuals …

Regulation Of The Edwardsiella Ictaluri Type Iii Secretion System By Ph And Phosphate Concentration Through Esra, Esrb, And Esrc, Matthew L. Rogge, Ronald L. Thune

Faculty Publications

A recently described Edwardsiella ictaluri type III secretion system (T3SS) with functional similarity to the Salmonella pathogenicity island 2 T3SS is required for replication in channel catfish head-kidney-derived macrophages (HKDM) and virulence in channel catfish. Quantitative PCR and Western blotting identified low pH and phosphate limitation as conducive to expression of the E. ictaluri T3SS, growth conditions that mimic the phagosomal environment. Mutagenesis studies demonstrated that expression is under the control of the EsrAB two-component regulatory system. EsrB also induces upregulation of the AraC-type regulatory protein EsrC, which enhances expression of the EscB/EseG chaperone/effector operon in concert with EsrB and …

Acquisition Of Rickettsia Felis By Cat Fleas During Feeding, Kathryn E. Reif, Michael T. Kearney, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Evidence for horizontal routes of transmission for Rickettsia felis has come from detection of R. felis infection in vertebrates and multiple blood-feeding arthropods; however, infection of cat fleas, Ctenocephalides felis, during blood feeding has not been demonstrated. In this study, the ability of cat fleas to acquire R. felis through an infectious blood meal with subsequent vertical transmission was examined. Utilizing an artificial feeding system, Rickettsia-naive fleas were exposed to R. felis-infected blood meals and monitored for subsequent infection at weekly intervals for 4 weeks. At 7 days postexposure (dpe) ∼52% of fleas successfully acquired rickettsiae and R. felis DNA; …

Altered Gene Expression And Spongiotrophoblast Differentiation In Placenta From A Mouse Model Of Diabetes In Pregnancy, J. M. Salbaum, C. Kruger, X. Zhang, N. Arbour Delahaye, G. Pavlinkova, D. H. Burk, C. Kappen

Faculty Publications

Aims/hypothesis: Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental function, and sought to identify cellular and molecular abnormalities in diabetic placenta. Methods: Using a mouse model of diabetic pregnancy, placental gene expression was assayed at mid-gestation and cellular composition analysed at various stages. Genome-wide expression profiling was validated by quantitative PCR and tissue localisation studies were performed to identify cellular correlates of altered gene expression in diabetic …

Compassionate Reappraisal And Emotion Suppression As Alternatives To Offense-Focused Rumination: Implications For Forgiveness And Psychophysiological Well-Being, Charlotte Vanoyen-Witvliet, Nathaniel J. Deyoung, Alicia J. Hofelich, Paul Deyoung

Faculty Publications

This within subjects experiment (28 females, 26 males) examined three responses to a past interpersonal offender. We contrasted offense-focused rumination with two subsequent, counterbalanced coping strategies: compassionate reappraisal and emotion suppression. Compassionate reappraisal emphasized the offender's human qualities and need for positive change. Emotion suppression inhibited the experience and expression of negative offense-related emotions. Offense rumination was associated with negative emotion, faster heartbeats (i.e., shortened electrocardiogram R-R intervals), and lower heart rate variability (HRV; i.e., the high-frequency component of the R-R power spectrum). By contrast, both compassionate reappraisal and emotion suppression decreased negative emotion in ratings and linguistic analyses, calmed …

Outsourcing Enforcement: Principles To Guide Self-Policing Regimes, Sarah L. Stafford

Faculty Publications

No abstract provided.

Postpartum Depression And Help‐Seeking Behaviors In Immigrant Hispanic Women, Lynn Clark Callister, Renea Beckstrand, Cheryl A. Corbett

Faculty Publications

Objectives: To describe perceptions of immigrant Hispanic women experiencing symptoms of postpartum depression (PPD) and to identify barriers to seeking mental health services.

Design: Qualitative descriptive.

Setting: Community health clinic.

Participants: Twenty immigrant Hispanic women scoring positive for symptoms of PPD receiving health care at a community health clinic who declined mental health services participated in audiotaped interviews held in their homes.

Methods: Following Institutional Review Board approval and informed consent, interviews were conducted with study participants. Transcribed data were analyzed as appropriate for qualitative inquiry.

Results: Some of the women did not recognize and/or denied their symptoms attributing their …

Widening Batson's Net To Ensnare More Than The Unapologetically Bigoted Or Painfully Unimaginative Attorney, Jeffrey Bellin, Junichi P. Semitsu

Faculty Publications

In Snyder v. Louisiana, the Supreme Court reaffirmed its commitment to rooting out racially discriminatory jury selection and its belief that the three-step framework established in Batson v. Kentucky is capable of unearthing racially discriminatory peremptory strikes. Yet the Court left in place the talismanic protection available to those who might misuse the peremptory challenge—the unbounded collection of justifications that courts, including the Supreme Court, accept as “race neutral.”

To evaluate the Court’s continuing faith in Batson, we conducted a survey of all federal published and unpublished judicial decisions issued in this first decade of the new millennium (2000–2009) that …

Christian's Aren't Perfect ...: Christ's Ministry In The Heavenly Sanctuary, Felix H. Cortez

Faculty Publications

No abstract provided.

Serum Igf-1 Concentrations Change With Soy And Seaweed Supplements In Healthy Postmenopausal American Women, Jane Teas, Mohammad R. Irhimeh, Susan Druker, Thomas G. Hurley, James R. Hébert, Todd M. Savarese, Mindy S. Kurzer

Faculty Publications

Insulin-like growth factor 1 (IGF-1) is an anabolic hormone important for growth and development. However, high-circulating serum concentrations in adults are associated with increased risk of postmenopausal breast cancer. Nutritional status and specific foods influence serum IGF-1 concentrations. Breast cancer incidence is typically low in Asian countries where soy is commonly consumed. Paradoxically, soy supplement trials in American women have reported significant increases in IGF-1. Seaweed also is consumed regularly in Asian countries where breast cancer risk is low. We investigated the possibility that seaweed could modify soy-associated increases in IGF-1 in American women. Thirty healthy postmenopausal women (mean age …

Enabling Refugee And Idp Law And Policy: Implications Of The U.N. Disability Convention On The Rights Of Persons With Disabilities, Michael Ashley Stein, Janet E. Lord

Faculty Publications

No abstract provided.

Consumption Behavior Of Chinese Urban Residents During Economic Transition: Intermittent And Cyclical Fluctuations, Xiaotong Jin, Shengliang Deng, Ilan Alon

Faculty Publications

Although in recent years researchers have attempted to examine the consumption behavior of Chinese residents during economic transition, there still exists a clear gap in the literature to adequately explain the consumption behavior of Chinese urban residents during economic restructuring. This paper, attempting to shed some light on this relationship, proposes a hypothesis of Chinese urban resident consumption behavior during economic transition in China and examines the hypothesis using quantitative models. The conclusion suggests that the consumption of Chinese urban residents is guided by traditional Chinese civilization, and this results in intermittent and cyclical fluctuations in consumption behavior during systemic …

"Christians Aren’T Perfect Just Forgiven": A Second Look To Christ’S Ministry In The Heavenly Sanctuary, Felix H. Cortez

Faculty Publications

No abstract provided.

Using Nanotechnology To Detect Nerve Agents, Mark N. Goltz, Dong-Shik Kim, Leeann Racz

Faculty Publications

Nanotechnology has opened a wide range of opportunities having potential impacts in areas as diverse as medicine and consumer products. In collaboration with researchers at the University of Toledo UT, Air Force Institute of Technology AFIT scientists are exploring the possibility of using a nanoscale organic matrix to detect organophosphate OP nerve agents. Current techniques for detecting OP compounds are expensive and time consuming. Developing a nanoscale organic matrix sensor would allow for direct, real-time sensing under field conditions. This article describes the science behind such a sensor and its possible applications. High-performance sensors are needed to protect Soldiers and …

Results Of The "Active By Choice Today" (Act) Randomized Trial For Increasing Physical Activity In Low-Income And Minority Adolescents, Dawn K. Wilson, M. Lee Van Horn, Heather Kitzman-Ulrich, Ruth P. Saunders, Russell R. Pate, Hannah G. Lawman, Brent Hutto, Sarah Griffin, Nicole Zarrett, Cheryl L. Addy, Leslie Mansard, Gary Mixon, Porschia V. Brown

Faculty Publications

Objective - This study reports the results of the "Active by Choice Today" (ACT) trial for increasing moderate-to-vigorous physical activity (MVPA) in low-income and minority adolescents.

Design - The ACT program was a randomized controlled school-based trial testing the efficacy of a motivational plus behavioral skills intervention on increasing MVPA in underserved adolescents. Twenty-four middle schools were matched on school size, percentage minorities, percentage free or reduced lunch, and urban or rural setting before randomization. A total of 1,563 6th grade students (mean age, 11.3 years, 73% African American, 71% free or reduced lunch, 55% female) participated in either a …

Regulatory Overlap, Overlapping Legal Fields, And Statutory Discontinuities, Todd S. Aagaard

Faculty Publications

Lawmakers and scholars alike criticize regulatory overlap on the ground that giving administrative agencies overlapping jurisdiction leads to duplicative or conflicting regulation which is inefficient and unduly burdensome. This Article challenges this orthodox account of regulatory overlap through examination of six case studies in which the Environmental Protection Agency and the Occupational Safety and Health Administration have managed their jurisdictional overlap so as to create regulatory synergy rather than dysfunction. Although this Article is not the first to argue that regulatory overlap may improve the effectiveness of regulatory programs, the case studies examined here highlight two important aspects of regulatory …

Adherence To Accelerometer Protocols Among Women From Economically Disadvantaged Neighborhoods, Patricia A. Sharpe, Sarah Wilcox, Laura J. Rooney, Donna Strong, Rosie Hopkins-Campbell, Jean Butel, Barbara E. Ainsworth, Deborah Parra-Medina

Faculty Publications

Background: Objective measurement of physical activity with accelerometers is a challenging task in community-based intervention research. Challenges include distribution of and orientation to monitors, nonwear, incorrect placement, and loss of equipment. Data collection among participants from disadvantaged populations may be further hindered by factors such as transportation challenges, competing responsibilities, and cultural considerations. Methods: Research staff distributed accelerometers and provided an orientation that was tailored to the population group. General adherence strategies such as follow-up calls, daily diaries, verbal and written instructions, and incentives were accompanied by population-specific strategies such as assisting with transportation, reducing obstacles to wearing the accelerometer, …

Infectivity Period Of Mice Inoculated With Human Adenoviruses, Rashmi Krishnapuram, Heather Kirk-Ballard, Aamri Zuberi, Nikhil V. Dhurandhar

Faculty Publications

Due to non-productive infections, mice are not a good model to study some human adenoviruses. However, mice provide an excellent model to study the metabolic effects of human adenovirus, Ad36. Research interest in Ad36 is increasing rapidly, and consequently an increase in the use of mice as a model is anticipated. However, little is known about the transmission potential of Ad36 from infected mice to other laboratory animals or personnel. While underestimating the infectivity could promote inadvertent spread of Ad36, overstating it could drain valuable laboratory resources and animals. Therefore, we determined the duration of infectivity in female C57BL/6J mice …

Engaging With Congress: An Unexpected Encounter, Barb Dutrow

Faculty Publications

No abstract provided.

Copy Number Variants In Candidate Genes Are Genetic Modifiers Of Hirschsprung Disease, Qian Jiang, Yen Yi Ho, Li Hao, Courtney Nichols Berrios, Aravinda Chakravarti

Faculty Publications

Hirschsprung disease (HSCR) is a neurocristopathy characterized by absence of intramural ganglion cells along variable lengths of the gastrointestinal tract. The HSCR phenotype is highly variable with respect to gender, length of aganglionosis, familiality and the presence of additional anomalies. By molecular genetic analysis, a minimum of 11 neuro-developmental genes (RET, GDNF, NRTN, SOX10, EDNRB, EDN3, ECE1, ZFHX1B, PHOX2B, KIAA1279, TCF4) are known to harbor rare, high-penetrance mutations that confer a large risk to the bearer. In addition, two other genes (RET, NRG1) harbor common, low-penetrance polymorphisms that contribute only partially to risk and can act as genetic modifiers. To …

Why Should States Pay For Prisons, When Local Officials Decide Who Goes There?, W. David Ball

Faculty Publications

In the United States, states typically pay for prisons, even though the decisions that lead to prison admissions — arresting, charging, and sentencing — are made by local officials. The practice of state subsidies is relatively recent: there were no state prisons in the early part of the country’s history, and even as state institutions began to be developed, they largely supported themselves financially, rendering the notion of subsidies moot. Given the political economy of local decision-making, local preferences are unlikely to result in optimally-sized state prison populations. This Article suggests that since state prison subsidies may not be desirable …

Surface Modification Of Droplet Polymeric Microfluidic Devices For The Stable And Continuous Generation Of Aqueous Droplets, Balamurugan Subramanian, Namwon Kim, Wonbae Lee, David A. Spivak, Dimitris E. Nikitopoulos, Robin L. Mccarley, Steven A. Soper

Faculty Publications

Droplet microfluidics performed in poly(methyl methacrylate) (PMMA) microfluidic devices resulted in significant wall wetting by water droplets formed in a liquid-liquid segmented flow when using a hydrophobic carrier fluid such as perfluorotripropylamine (FC-3283). This wall wetting led to water droplets with nonuniform sizes that were often trapped on the wall surfaces, leading to unstable and poorly controlled liquid-liquid segmented flow. To circumvent this problem, we developed a two-step procedure to hydrophobically modify the surfaces of PMMA and other thermoplastic materials commonly used to make microfluidic devices. The surface-modification route involved the introduction of hydroxyl groups by oxygen plasma treatment of …

Media Attention On African Americans With Human Immunodeficiency Virus, Charles S. Beverley Jr., Edith M. Williams, Saundra H. Glover

Faculty Publications

Human immunodeficiency virus (HIV) is a disease that has captured the attention of the media in various ways and to varying degrees. One of the ongoing debates and areas of research in HIV that provide many opportunities for discovery is the disproportionate number of African Americans infected with HIV compared to the amount of attention they receive in the media. This manuscript addresses the question that has preoccupied the minds of many people: Why have African Americans infected with HIV received so little media attention? Analysis of this question suggests that there are many reasons for this lack of media …

Two Distinct Ferritin-Like Molecules In Pseudomonas Aeruginosa: The Product Of The Bfra Gene Is A Bacterial Ferritin (Ftna) And Not A Bacterioferritin (Bfr), Huili Yao, Grace Jepkorir, Scott Lovell, Pavithra V. Nama, Saroja Weeratunga, Kevin P. Battaile, Mario Rivera

Faculty Publications

Two distinct types of ferritin-like molecules often coexist in bacteria, the heme binding bacterioferritins (Bfr) and the non-heme binding bacterial ferritins (Ftn). The early isolation of a ferritin-like molecule from Pseudomonas aeruginosa suggested the possibility of a bacterioferritin assembled from two different subunits [Moore, G. R., et al. (1994) Biochem. J. 304, 493-497]. Subsequent studies demonstrated the presence of two genes encoding ferritin-like molecules in P. aeruginosa, designated bfrA and bfrB, and suggested that two distinct bacterioferritins may coexist [Ma, J.-F., et al. (1999) J. Bacteriol. 181, 3730-3742]. In this report, we present structural evidence demonstrating that the product of …