Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Faculty Publications

Discipline
Institution
Keyword
Publication Year
File Type

Articles 8521 - 8550 of 14434

Full-Text Articles in Entire DC Network

Rna Interference-Mediated Depletion Of N-Ethylmaleimide Sensitive Fusion Protein And Synaptosomal Associated Protein Of 25 Kda Results In The Inhibition Of Blood Feeding Of The Gulf Coast Tick, Amblyomma Maculatum, Rebecca Browning, Shahid Karim Jun 2013

Rna Interference-Mediated Depletion Of N-Ethylmaleimide Sensitive Fusion Protein And Synaptosomal Associated Protein Of 25 Kda Results In The Inhibition Of Blood Feeding Of The Gulf Coast Tick, Amblyomma Maculatum, Rebecca Browning, Shahid Karim

Faculty Publications

The signalling pathways in tick salivary glands that control ‘sialo‐secretome’ secretion at the tick−host interface remain elusive; however, this complex process is essential for successful feeding and manipulation of the host haemostatic response. Exocytosis of the sialo‐secretome in the salivary glands requires a core of soluble N‐ethylmaleimide‐sensitive fusion (NSF) attachment proteins (SNAPs) and receptor proteins (SNAREs). SNAREs have been identified as the key components in regulating the sialo‐secretome in the salivary gland cells. In this study, we utilized RNA interference to investigate the functional role of two Amblyomma maculatum SNARE complex proteins, AmNSF and AmSNAP‐25, in the tick salivary glands …

Go to article

Interventions For Improving Nutrition And Physical Activity Behaviors In Adult African American Populations: A Systematic Review, January 2000 Through December 2011, Jennifer Lemacks, Brittny A. Wells, Jasminka Z. Ilich, Penny A. Ralston Jun 2013

Interventions For Improving Nutrition And Physical Activity Behaviors In Adult African American Populations: A Systematic Review, January 2000 Through December 2011, Jennifer Lemacks, Brittny A. Wells, Jasminka Z. Ilich, Penny A. Ralston

Faculty Publications

Introduction The incidence of preventable chronic diseases is disproportionally high among African Americans and could be reduced through diet and physical activity interventions. Our objective was to systematically review the literature on clinical outcomes of diet and physical activity interventions conducted among adult African American populations in the United States. Methods We used the Preferred Reporting Items for Systematic Review and Meta Analysis construct in our review. We searched Medline (PubMed and Ovid), Cochrane, and DARE databases and restricted our search to articles published in English from January 2000 through December 2011. We included studies of educational interventions with clinically …

Go to article

Herbert Hoover And Belgian Relief, Albert Winkler Jun 2013

Herbert Hoover And Belgian Relief, Albert Winkler

Faculty Publications

Herbert Hoover was an orphan, who retained great empathy for the weak and hungry his entire life. Working without pay, he organized and administered Belgian Relief starting in 1914 to get food to ten million Belgians and Frenchmen behind German lines. His efforts doubtlessly saved hundreds of thousands from starvation. This was only the starting point in his career as the "Great Humanitarian." He got food to Germany at the end of both world wars, aided Russia in their great famine, and reportedly got food to hundreds of millions of people in his lengthy career. No one has ever done …

Go to article

Exceed: Excellence In Your Engineering Education Summer Transition Program, Stacy Gleixner, Katherine Casey, Jared Tuberty, S. Latic, Patricia Backer, Emily Allen Jun 2013

Exceed: Excellence In Your Engineering Education Summer Transition Program, Stacy Gleixner, Katherine Casey, Jared Tuberty, S. Latic, Patricia Backer, Emily Allen

Faculty Publications

EXCEED: Excellence in Your Engineering Education is a ten day, residential summer transition program that was designed to improve retention and graduation rates at San José State University (SJSU). SJSU is a large, public institution in the West with a very diverse student population. However, the university has lower graduation and retention rates for certain student populations in engineering including underrepresented groups and first generation college students. This transition program was designed to meet five outcomes: acculturate the students to the College of Engineering and the university, enhance math and writing preparation, build community amongst the cohort of students, enhance …

Go to article

Β-Pyrazino-Fused Tetrarylporphyrins, Federica Mandoj, Sara Nardis, Rajesh Pudi, Larisa Lvova, Frank R. Fronczek, Kevin M. Smith, Luca Prodi, Damiano Genovese, Roberto Paolesse May 2013

Β-Pyrazino-Fused Tetrarylporphyrins, Federica Mandoj, Sara Nardis, Rajesh Pudi, Larisa Lvova, Frank R. Fronczek, Kevin M. Smith, Luca Prodi, Damiano Genovese, Roberto Paolesse

Faculty Publications

A novel method for the preparation of β-fused porphyrin dyads was developed that exploits a one-pot reaction of 2,3-diaminoporphyrins with diethyl oxalate. This approach provides good yields of the zinc β-fused dyad and the corresponding free-base, opening the way for preparation of several metal derivatives to permit modulation of optoelectronic characteristics for commercial applications. © 2013 Elsevier B.V. All rights reserved.

Go to article

Dissemination Of Bloodmeal Acquired Rickettsia Felis In Cat Fleas, Ctenocephalides Felis, Chutima Thepparit, Supanee Hirunkanokpun, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso May 2013

Dissemination Of Bloodmeal Acquired Rickettsia Felis In Cat Fleas, Ctenocephalides Felis, Chutima Thepparit, Supanee Hirunkanokpun, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Background: Cat fleas, Ctenocephalides felis, are known biological vectors for Rickettsia felis. Rickettsial transmission can be vertical via transovarial transmission within a flea population, as well as horizontal between fleas through a bloodmeal. The previously undescribed infection kinetics of bloodmeal-acquired R. felis in cat fleas provides insight into the R. felis-flea interaction. Findings. In the present study, dissemination of R. felis in previously uninfected cat fleas fed an R. felis-infected bloodmeal was investigated. At weekly intervals for 28 days, rickettsial propagation, accumulation, and dissemination in gut epithelial cells, specifically in the hindgut and the specialized cells in the neck region …

Go to article

The Effects Of Practice On The Concurrent Performance Of A Speech And Postural Task In Persons With Parkinson Disease And Healthy Controls, K. Bo Foreman, Stuart Sondrup, Christopher Dromey, Eon Jarvis, Shawn Nissen, Leland E. Dibble May 2013

The Effects Of Practice On The Concurrent Performance Of A Speech And Postural Task In Persons With Parkinson Disease And Healthy Controls, K. Bo Foreman, Stuart Sondrup, Christopher Dromey, Eon Jarvis, Shawn Nissen, Leland E. Dibble

Faculty Publications

Purpose. Persons with Parkinson disease (PD) demonstrate deficits in motor learning as well as bidirectional interference (the performance of one task concurrently interferes with the performance of another task) during dual-task performance. Few studies have examined the practice dosages necessary for behavioral change in rehabilitation relevant tasks. Therefore, to compare the effects of age and PD on motor learning during dual-task performance, this pilot study examined persons with PD as well as neurologically healthy participants during concurrent performance of postural and speaking tasks. Methods. Seven persons with PD and 7 healthy age-matched and 10 healthy young control subjects …

Go to article

Cultural Aspects Of Latino Early Childhood Obesity, Lauren Clark, Susan L. Johnson, Mary E. O'Connor, Jane H. Lassetter May 2013

Cultural Aspects Of Latino Early Childhood Obesity, Lauren Clark, Susan L. Johnson, Mary E. O'Connor, Jane H. Lassetter

Faculty Publications

The problem of Latino childhood obesity is well known, and experts agree that the sooner it is addressed in a child’s life, the better. Strong evidence from nationwide studies suggests that obesity begins in infancy for Mexican Americans. National data demonstrate the dramatic increase in weight-for-recumbent length above the 95th percentile (using the NCHS growth chart) among Mexican American children between National Health and Nutrition Examination Survey (NHANES) and the Third National Health and Nutrition Examination Survey (NHANES III) (Ogden et al., 2006). High rates of childhood obesity affect the long-term health potential of children, since childhood obesity tracks into …

Go to article

The Predicted Relative Risk Of Premature Ovarian Failure For Three Radiotherapy Modalities In A Girl Receiving Craniospinal Irradiation, A. Pérez-Andújar, W. D. Newhauser, P. J. Taddei, A. Mahajan, R. M. Howell May 2013

The Predicted Relative Risk Of Premature Ovarian Failure For Three Radiotherapy Modalities In A Girl Receiving Craniospinal Irradiation, A. Pérez-Andújar, W. D. Newhauser, P. J. Taddei, A. Mahajan, R. M. Howell

Faculty Publications

In girls and young women, irradiation of the ovaries can reduce the number of viable ovarian primordial follicles, which may lead to premature ovarian failure (POF) and subsequently to sterility. One strategy to minimize this late effect is to reduce the radiation dose to the ovaries. A primary means of reducing dose is to choose a radiotherapy technique that avoids irradiating nearby normal tissue; however, the relative risk of POF (RRPOF) due to the various therapeutic options has not been assessed. This study compared the predicted RRPOF after craniospinal proton radiotherapy, conventional photon radiotherapy (CRT) and intensity-modulated photon radiotherapy (IMRT). …

Go to article

Multitissue Molecular, Genomic, And Developmental Effects Of The Deepwater Horizon Oil Spill On Resident Gulf Killifish (Fundulus Grandis), Benjamin Dubansky, Andrew Whitehead, Jeffrey T. Miller, Charles D. Rice, Fernando Galvez May 2013

Multitissue Molecular, Genomic, And Developmental Effects Of The Deepwater Horizon Oil Spill On Resident Gulf Killifish (Fundulus Grandis), Benjamin Dubansky, Andrew Whitehead, Jeffrey T. Miller, Charles D. Rice, Fernando Galvez

Faculty Publications

The Deepwater Horizon oil rig disaster resulted in crude oil contamination along the Gulf coast in sensitive estuaries. Toxicity from exposure to crude oil can affect populations of fish that live or breed in oiled habitats as seen following the Exxon Valdez oil spill. In an ongoing study of the effects of Deepwater Horizon crude oil on fish, Gulf killifish (Fundulus grandis) were collected from an oiled site (Grande Terre, LA) and two reference locations (coastal MS and AL) and monitored for measures of exposure to crude oil. Killifish collected from Grande Terre had divergent gene expression in the liver …

Go to article

Pre-Immunization With An Intramuscular Injection Of Aav9-Human Erythropoietin Vectors Reduces The Vector-Mediated Transduction Following Re-Administration In Rat Brain, Chun Yang, Wei Hua Yang, Sha Sha Chen, Bao Feng Ma, Bin Li, Tao Lu, Ting Yu Qu, Ronald L. Klein, Li Ru Zhao, Wei Ming Duan May 2013

Pre-Immunization With An Intramuscular Injection Of Aav9-Human Erythropoietin Vectors Reduces The Vector-Mediated Transduction Following Re-Administration In Rat Brain, Chun Yang, Wei Hua Yang, Sha Sha Chen, Bao Feng Ma, Bin Li, Tao Lu, Ting Yu Qu, Ronald L. Klein, Li Ru Zhao, Wei Ming Duan

Faculty Publications

We have recently demonstrated that adeno-associated virus serotype 9 (AAV9)-mediated human erythropoietin (hEPO) gene delivery into the brain protects dopaminergic (DA) neurons in the substantia nigra in a rat model of Parkinson's disease. In the present study, we examined whether pre-exposure to AAV9-hEPO vectors with an intramuscular or intrastriatal injection would reduce AAV9-mediated hEPO transduction in rat brain. We first characterized transgene expression and immune responses against AAV9-hEPO vectors in rat striatum at 4 days, 3 weeks and 6 months, and with doses ranging from 1011 to 1013 viral genomes. To sensitize immune system, rats received an injection of AAV9-hEPO …

Go to article

Lead Uptake In Diverse Plant Families: A Study Applying X-Ray Absorption Near Edge Spectroscopy, Gudrun L. Bovenkamp, Alexander Prange, Wolfgang Schumacher, Kyungmin Ham, Aaron P. Smith, Josef Hormes May 2013

Lead Uptake In Diverse Plant Families: A Study Applying X-Ray Absorption Near Edge Spectroscopy, Gudrun L. Bovenkamp, Alexander Prange, Wolfgang Schumacher, Kyungmin Ham, Aaron P. Smith, Josef Hormes

Faculty Publications

The chemical environment of lead in roots and leaves of plants from four different plant families and a lichen from a former lead mining site in the Eifel Mountains in Germany was determined by Pb L3-edge XANES measurements using solid reference compounds and also aqueous solutions of different ionic strength simulating the plant environment. Pb2+ ions in the plants were found to have two major coordinations, one with nine oxygen atoms in the first coordination shell similar to outer-sphere complexation and a second coordination with just three oxygen atoms similar to inner-sphere complexation. This can be interpreted assuming that lead …

Go to article

Tar Balls From Deep Water Horizon Oil Spill: Environmentally Persistent Free Radicals (Epfr) Formation During Crude Weathering, Lucy W. Kiruri, Barry Dellinger, Slawo Lomnicki May 2013

Tar Balls From Deep Water Horizon Oil Spill: Environmentally Persistent Free Radicals (Epfr) Formation During Crude Weathering, Lucy W. Kiruri, Barry Dellinger, Slawo Lomnicki

Faculty Publications

Tar balls collected from the Gulf of Mexico shores of Louisiana and Florida after the BP oil spill have shown the presence of electron paramagnetic resonance (EPR) spectra characteristic of organic free radicals as well as transition metal ions, predominantly iron(III) and manganese(II). Two types of organic radicals were distinguished: an asphaltene radical species typically found in crude oil (g = 2.0035) and a new type of radical resulting from the environmental transformations of crude (g = 2.0041-47). Pure asphaltene radicals are resonance stabilized over a polyaromatic structure and are stable in air and unreactive. The new radicals were identified …

Go to article

Debriefing Simulations: Comparison Of Debriefing With Video And Debriefing Alone, Shelly J. Reed, Claire M. Andrews, Patricia K. Ravert May 2013

Debriefing Simulations: Comparison Of Debriefing With Video And Debriefing Alone, Shelly J. Reed, Claire M. Andrews, Patricia K. Ravert

Faculty Publications

Background: Debriefing as part of the simulation experience is regarded as essential for learning. Evidence concerning best debriefing practices from the standpoint of a student nurse participant is minimal, particularly when comparing debriefing types. This study evaluated the differences in the student experience between two debriefing types: debriefing with video and debriefing without video (debriefing alone). Method: Nursing students participating in an intensive care simulation were randomized into one of the two debriefing types: debriefing with video (n = 32) and debriefing alone (n = 32) following simulation completion. After debriefing was completed, studentswere asked to complete a debriefing experience …

Go to article

Triterpenoid Saponins From Eryngium Yuccifolium ‘Kershaw Blue’ (Abstract), Ping Wang, Wei Yuan, Guangrui Deng, Zushang Su, Shiyou Li May 2013

Triterpenoid Saponins From Eryngium Yuccifolium ‘Kershaw Blue’ (Abstract), Ping Wang, Wei Yuan, Guangrui Deng, Zushang Su, Shiyou Li

Faculty Publications

Abstract attached

Go to article

A Springtime Source Of Toxic Pseudo-Nitzschia Cells On Razor Clam Beaches In The Pacific Northwest, Barbara Hickey, Vera Trainer, P. Kosro, Nicolaus Adams, Thomas Connolly, Nancy Kachel, Susan Geier May 2013

A Springtime Source Of Toxic Pseudo-Nitzschia Cells On Razor Clam Beaches In The Pacific Northwest, Barbara Hickey, Vera Trainer, P. Kosro, Nicolaus Adams, Thomas Connolly, Nancy Kachel, Susan Geier

Faculty Publications

Concentrations of domoic acid (DA) above the regulatory limit in Washington coast razor clams are usually higher on northern beaches from summer to fall. Recent field studies have confirmed that the primary source of toxic Pseudo-nitzschia (PN) cells in those seasons is a semi-retentive topographically trapped seasonal eddy located offshore and north of the clamming beaches. Another semi-retentive coastal feature, Heceta Bank, that has been shown to support toxic PN cells in summer, is located south of Washington’s clamming beaches. In this paper we present evidence to demonstrate that Heceta Bank, although not a likely source of toxic cells to …

Go to article

Measure For Measure And The Discourse Of Husbandry, Benjamin Bertram Phd May 2013

Measure For Measure And The Discourse Of Husbandry, Benjamin Bertram Phd

Faculty Publications

The article explores early modern husbandry, which are more focused on encouraging its readers to lead pious, productive and economical lives. In "Measure for Measure," by William Shakespeare, the play centers on the rise of state husbandry as it focused on the parallels between Duke Vincentio and James I and views of sex and marriage. According to the author, there are two competing views of sex in the work including Lucio's pleasurable economy that resists the order of state husbandry.

Go to article

Characterization Of Virus-Encoded Rna Interference Suppressors In Caenorhabditis Elegans, Xunyang Guo, Rui Lu May 2013

Characterization Of Virus-Encoded Rna Interference Suppressors In Caenorhabditis Elegans, Xunyang Guo, Rui Lu

Faculty Publications

In fungi, plants, and invertebrates, antiviral RNA interference (RNAi) directed by virus-derived small interfering RNAs (siRNAs) represents a major antiviral defense that the invading viruses have to overcome in order to establish infection. As a counterdefense mechanism, viruses of these hosts produce diverse classes of proteins capable of suppressing the biogenesis and/or function of viral siRNAs. This RNA-directed viral immunity (RDVI) in the nematode Caenorhabditis elegans is known to exhibit some unique features. Currently, little is known about viral suppression of RNAi in C. elegans. Here, we show that ectopic expression of the B2 protein encoded by Flock House virus …

Go to article

Molecular Characterization And Functional Significance Of The Vti Family Of Snare Proteins In Tick Salivary Glands, Ashley M. Villarreal, Steven W. Adamson, Rebecca E. Browning, Khemraj Budachetri, Muhammad Sohail Sajid, Shahid Karim May 2013

Molecular Characterization And Functional Significance Of The Vti Family Of Snare Proteins In Tick Salivary Glands, Ashley M. Villarreal, Steven W. Adamson, Rebecca E. Browning, Khemraj Budachetri, Muhammad Sohail Sajid, Shahid Karim

Faculty Publications

Exocytosis involves membrane fusion between secretory vesicles and the plasma membrane. The Soluble N-ethylmaleimide-sensitive factor attachment proteins (SNAPs) and their receptor proteins (SNAREs) interact to fuse vesicles with the membrane and trigger the release of their sialosecretome out of the tick salivary gland cells. In this study, we examined the functional significance of the Vti family of SNARE proteins of blood-feeding Amblyomma maculatum and Amblyomma americanum. Vti1A and Vti1B have been implicated in multiple functional roles in vesicle transport. QRT-PCR studies demonstrated that the highest transcriptional expression of vti1a and vti1b genes occurs in unfed salivary glands, suggesting that …

Go to article

Socio-Ecology Of The Marsh Rice Rat (Oryzomys Palustris) And The Spatio-Temporal Distribution Of Bayou Virus In Coastal Texas, Tyla S. Holsomback, Christopher J. Van Nice, Rachel N. Clark, Alisa A. Abuzeineh, Jorge Salazar-Bravo May 2013

Socio-Ecology Of The Marsh Rice Rat (Oryzomys Palustris) And The Spatio-Temporal Distribution Of Bayou Virus In Coastal Texas, Tyla S. Holsomback, Christopher J. Van Nice, Rachel N. Clark, Alisa A. Abuzeineh, Jorge Salazar-Bravo

Faculty Publications

Along the southeastern coast of the United States of America (USA), the marsh rice rat (Oryzomys palustris) is the primary host for the hantavirus genotype Bayou. According to the socio-ecological model for a territorial, polygamous species, females should be distributed across space and time by habitat resources and predation risks, whereas males should space themselves according to the degree of female aggregation and reproductive synchrony. To investigate how females affect the male-male transmission paradigm of Bayou virus, rodents were captured, marked, released, and re-captured in two macrohabitat types across a 30-month period. Microhabitat cover variables were quantified around …

Go to article

Resistant Starch From High Amylose Maize (Ham-Rs2) Reduces Body Fat And Increases Gut Bacteria In Ovariectomized (Ovx) Rats, Michael J. Keenan, Marlene Janes, Julina Robert, Roy J. Martin, Anne M. Raggio, Kathleen L. Mccutcheon, Christine Pelkman, Richard Tulley, M'Famara Goita, Holiday A. Durham, June Zhou, Reshani N. Senevirathne May 2013

Resistant Starch From High Amylose Maize (Ham-Rs2) Reduces Body Fat And Increases Gut Bacteria In Ovariectomized (Ovx) Rats, Michael J. Keenan, Marlene Janes, Julina Robert, Roy J. Martin, Anne M. Raggio, Kathleen L. Mccutcheon, Christine Pelkman, Richard Tulley, M'Famara Goita, Holiday A. Durham, June Zhou, Reshani N. Senevirathne

Faculty Publications

Objective: Obesity after menopause is a health concern for older females. Changes in the microbiota are likely to occur with this condition. Modifying the microbiota with a prebiotic is a plausible strategy for improving the health of menopausal females. Design and Methods: Resistant starch type 2 from high-amylose maize (HAM-RS2) was used as a prebiotic in rats in a 2 × 2 factorial study with two levels of HAM-RS2 (0 or 29.7% of weight of diet) referred to as energy control (EC) and HAM-RS2 diets, respectively; and two levels of surgery, ovariectomized (OVX) and sham. Results: In a 6-week, postsurgery …

Go to article

Medical Home Model Of Patient-Centered Health Care, Sandra N. Berryman, Sheri P. Palmer, James E. Kohl, Jon S. Parham May 2013

Medical Home Model Of Patient-Centered Health Care, Sandra N. Berryman, Sheri P. Palmer, James E. Kohl, Jon S. Parham

Faculty Publications

The medical home offers a patient-centered model of care. The foundation of a medical home is the organized and continuous interprofessional care of patients.

Go to article

Election Delays In 2012, Rebecca Green, Emily Lippolis, Shanna Reulbach, Andrew Mccoy May 2013

Election Delays In 2012, Rebecca Green, Emily Lippolis, Shanna Reulbach, Andrew Mccoy

Faculty Publications

No abstract provided.

Go to article

Toxicologic Assessment Of A Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily Of The Desert Filtered Whole Leaf Juice With Aloesorb, Inder Sehgal, Wallace D. Winters, Michael Scott, Andrew David, Glenn Gillis, Thaya Stoufflet, Anand Nair, Konstantine Kousoulas Apr 2013

Toxicologic Assessment Of A Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily Of The Desert Filtered Whole Leaf Juice With Aloesorb, Inder Sehgal, Wallace D. Winters, Michael Scott, Andrew David, Glenn Gillis, Thaya Stoufflet, Anand Nair, Konstantine Kousoulas

Faculty Publications

Aloe vera, a common ingredient in cosmetics, is increasingly being consumed as a beverage supplement. Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasia and ultimately malignancy. We tested a decolorized whole leaf (DCWL) aloe vera, treated with activated charcoal to remove the latex portion of the plant, for genotoxicity in bacteria, acute/subacute toxicity in B6C3F1 mice, and subchronic toxicity in F344 rats. We found …

Go to article

The Hemophore Hasa From Yersinia Pestis (HasaYp) Coordinates Hemin With A Single Residue, Tyr75, And With Minimal Conformational Change, Ritesh Kumar, Scott Lovell, Hirotoshi Matsumura, Kevin P. Battaile, Pierre Moënne-Loccoz, Mario Rivera Apr 2013

The Hemophore Hasa From Yersinia Pestis (HasaYp) Coordinates Hemin With A Single Residue, Tyr75, And With Minimal Conformational Change, Ritesh Kumar, Scott Lovell, Hirotoshi Matsumura, Kevin P. Battaile, Pierre Moënne-Loccoz, Mario Rivera

Faculty Publications

Hemophores from Serratia marcescens (HasAsm) and Pseudomonas aeruginosa (HasAp) bind hemin between two loops, which harbor the axial ligands H32 and Y75. Hemin binding to the Y75 loop triggers closing of the H32 loop and enables binding of H32. Because Yersinia pestis HasA (HasA yp) presents a Gln at position 32, we determined the structures of apo- and holo-HasAyp. Surprisingly, the Q32 loop in apo-HasA yp is already in the closed conformation, but no residue from the Q32 loop binds hemin in holo-HasAyp. In agreement with the minimal reorganization between the apo- and holo-structures, the hemin on-rate is too fast …

Go to article

Eight Weeks Of Supplementation With A Multi-Ingredient Weight Loss Product Enhances Body Composition, Reduces Hip And Waist Girth, And Increases Energy Levels In Overweight Men And Women, Hector L. Lopez, Tim N. Ziegenfuss, Jennifer E. Hofheins, Scott M. Habowski, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Joseph P. Weir, Arny A. Ferrando Apr 2013

Eight Weeks Of Supplementation With A Multi-Ingredient Weight Loss Product Enhances Body Composition, Reduces Hip And Waist Girth, And Increases Energy Levels In Overweight Men And Women, Hector L. Lopez, Tim N. Ziegenfuss, Jennifer E. Hofheins, Scott M. Habowski, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Joseph P. Weir, Arny A. Ferrando

Faculty Publications

Background: Numerous natural products are marketed and sold claiming to decrease body weight and fat, but few undergo finished product-specific research demonstrating their safety and efficacy.Objective: To determine the safety and efficacy of a multi-ingredient supplement containing primarily raspberry ketone, caffeine, capsaicin, garlic, ginger and Citrus aurantium (Prograde Metabolism™ [METABO]) as an adjunct to an eight-week weight loss program.Methods: Using a randomized, placebo-controlled, double-blind design, 70 obese but otherwise healthy subjects were randomly assigned to METABO or a placebo and underwent 8 weeks of daily supplementation, a calorie restricted diet, and exercise training. Subjects were tested for changes in body …

Go to article

Multi-Year Salutary Effects Of Windstorm And Fire On River Cane, Paul R. Gagnon, Heather A. Passmore, William J. Platt Apr 2013

Multi-Year Salutary Effects Of Windstorm And Fire On River Cane, Paul R. Gagnon, Heather A. Passmore, William J. Platt

Faculty Publications

Canebrakes are monodominant stands of cane (Arundinaria gigantea [Walter] Muhl.), a bamboo native to and once prominent in the southeastern USA. Canebrakes were important wildlife habitat within the bottomland hardwood forest ecosystem. They have been reduced in areal coverage by an estimated 98% since European settlement due to land conversion and the drastic alteration of disturbance regimes in their floodplain habitat. Ongoing canebrake restoration efforts are hampered by incomplete understanding of the role of natural disturbance in cane ecology. We used a large tornado blow down and multiple prescribed fires to quantify the response of cane to the sequential disturbances …

Go to article

Revisiting Blob Theory For Dna Diffusivity In Slitlike Confinement, Liang Dai, Douglas R. Tree, Johan R. C. Van Der Maarel, Kevin D. Dorfman, Patrick S. Doyle Apr 2013

Revisiting Blob Theory For Dna Diffusivity In Slitlike Confinement, Liang Dai, Douglas R. Tree, Johan R. C. Van Der Maarel, Kevin D. Dorfman, Patrick S. Doyle

Faculty Publications

Blob theory has been widely applied to describe polymer conformations and dynamics in nanoconfinement. In slit confinement, blob theory predicts a scaling exponent of 2/3 for polymer diffusivity as a function of slit height, yet a large body of experimental studies using DNA produce a scaling exponent significantly less than 2/3. In this work, we develop a theory that predicts that this discrepancy occurs because the segment correlation function for a semiflexible chain such as DNA does not follow the Flory exponent for length scales smaller than the persistence length. We show that these short length scale effects contribute significantly …

Go to article

Clinical And Molecular Models Of Glioblastoma Multiforme Survival, R. Piccolo Stephen, J. Frey Lewis Apr 2013

Clinical And Molecular Models Of Glioblastoma Multiforme Survival, R. Piccolo Stephen, J. Frey Lewis

Faculty Publications

Glioblastoma multiforme (GBM), a highly aggressive form of brain cancer, results in a median survival of 12–15 months. For decades, researchers have explored the effects of clinical and molecular factors on this disease and have identified several candidate prognostic markers. In this study, we evaluated the use of multivariate classification models for differentiating between subsets of patients who survive a relatively long or short time. Data for this study came from The Cancer Genome Atlas (TCGA), a public repository containing clinical, treatment, histological and biomolecular variables for hundreds of patients. We applied variable-selection and classification algorithms in a cross-validated design …

Go to article

The Top 10 Trends In International Environmental Law, Tseming Yang Apr 2013

The Top 10 Trends In International Environmental Law, Tseming Yang

Faculty Publications

This chapter reviews the top trends in international environmental law, including climate change, globalization of environmental law, sustainable development, the rise of the developing world, environmental institutions and governance, human rights and the environment, the environment and international economic law, biodiversity, chemicals and hazardous substances management, and the oceans and fisheries.

Go to article

First Prev Next Last