Digital Commons Network^™

Discovering Volatile Chemicals From Window Weatherstripping Through Solid-Phase Microextraction/Gas Chromatography-Mass Spectrometry, Cornelia Rosu, Rafael Cueto, Lucas Veillon, Connie David, Roger A. Laine, Paul S. Russo

Faculty Publications

© 2017 The American Chemical Society and Division of Chemical Education, Inc. Volatile compounds from polymeric materials such as weatherstripping were identified by solid-phase microextraction (SPME), a solvent-free analytical method, coupled to gas chromatography-mass spectrometry (GC-MS). These compounds, originating from additives and fillers used in weatherstripping processing, were mostly polycyclic aromatic hydrocarbons (PAHs). The goal of this laboratory experiment was to demonstrate that a reliable connection can be established between the ability of our everyday olfactory sense to detect noxious odors and modern analytical instrumentation. The approach discussed here will guide students to develop critical thinking by interchanging between polymer …

Individual Differences In Eeg Correlates Of Recognition Memory Due To Dat Polymorphisms, Paolo Medrano, Erika Nyhus, Andrew Smolen, Tim Curran, Robert S. Ross

Faculty Publications

Introduction

Although previous research suggests that genetic variation in dopaminergic genes may affect recognition memory, the role dopamine transporter expression may have on the behavioral and EEG correlates of recognition memory has not been well established.

Objectives

The study aims to reveal how individual differences in dopaminergic functioning due to genetic variations in the dopamine transporter gene influences behavioral and EEG correlates of recognition memory.

Methods

Fifty‐eight participants performed an item recognition task. Participants were asked to retrieve 200 previously presented words while brain activity was recorded with EEG. Regions of interest were established in scalp locations associated with recognition …

What's It To Me? Self-Interest And Evaluations Of Financial Conflicts Of Interest, Samuel Bruton, Donald Sacco

Faculty Publications

Disclosure has become the preferred way of addressing the threat to researcher objectivity arising from financial conflicts of interest (FCOIs). This article argues that the effectiveness of disclosure at protecting science from the corrupting effects of FCOIs—particularly the kind of disclosure mandated by US federal granting agencies—is more limited than is generally acknowledged. Current NIH and NSF regulations require disclosed FCOIs to be reviewed, evaluated, and managed by officials at researchers’ home institutions. However, these reviewers are likely to have institutional and personal interests of their own that may undermine the integrity of their evaluations. This paper presents experimental findings …

Are Our Policymakers On Board? A Systematic Review Of U.S. Policymakers’ Views On The Social Determinants Of Health, Health Disparities, Health Equity, & Health In All Policies, M. Lelinneth B. Novilla, Michael C. Goates, Spencer Calder, Laura A. Galvao, Tabetha Ellis, Kraymer Eppich, Noyra Melissa Quintana, David Mateos, Russell Doria

Faculty Publications

BACKGROUND: Policies shape our society and influence our health. Poor social policies and bad politics create a collective social milieu that result in health inequities. Closing the health gap in our communities will require tackling these root causes. But how are U.S. policymakers addressing the social conditions that negatively influence health?

OBJECTIVE: Identify the social determinants of health perceived as legislative priorities by U.S. policymakers and the factors that facilitate/hinder their intent to act on the social determinants of health.

METHODS: A systematic review of 1,832 newspaper, magazine, and journal articles published between January 2000 and July 2016 yielded 202 …

Antibiotic Stewardship: The Role Of Clinical Nurses And Nurse Educators, Sharon Sumner, Sandra Forsyth, Katreena Collette Merrill, Caroline Taylor, Todd Vento, John Veillette, Brandon Webb

Faculty Publications

Within 10 years of the breakthrough development of Penicillin, antibiotic resistance was reported. According to the Centers for Disease Control (CDC) and Prevention (CDC, 2017), each year 2 million cases of antibiotic resistant bacteria occur resulting in approximately 23,000 deaths in the United States. The World Health Organization (WHO) also reports that approximately 25,000 people die from antibiotic resistant organisms annually in the European Union (WHO, 2014). To combat these alarming trends, antibiotic stewardship (AS) programs have been strongly recommended by the WHO, the National Institute for Health and Care Excellence (NICE) Centers for Disease Control and Prevention (CDC), the …

The Role Of Feature-Based Discrimination In Driving Health Disparities Among Black Americans, Randl B. Dent, Nao Hagiwara, Elena V. Stepanova, Tiffany L. Green

Faculty Publications

Objective: A growing body of research finds that darker skin tone is often associated with poorer physical and mental health in Blacks. However, the psychosocial mechanisms underlying the skin tone-health link remain elusive. The present study seeks to address this knowledge gap by investigating the direct and indirect (through perceived discrimination, socioeconomic status, and self-esteem) effects of skin tone on self-reported physical and mental health.

Design: An urban sample of 130 Blacks aged 35 and above completed a self-administered computerized survey as a part of larger cross-sectional study.

Results: Self-esteem played a particularly important role in mediating the associations between …

Transcription-Driven Dna Methylation Setting On The Mouse Peg3 Locus, Corey L. Bretz, Joomyeong Kim

Faculty Publications

© 2017 Taylor & Francis Group, LLC. The imprinting of the mouse Peg3 domain is controlled through the Peg3-DMR, which obtains its maternal-specific DNA methylation during oogenesis. In the current study, we deleted an oocyte-specific alternative promoter, termed U1, which is localized 20 kb upstream of the Peg3-DMR. Deletion of this alternative promoter resulted in complete removal of the maternal-specific DNA methylation on the Peg3-DMR. Consequently, the imprinted genes in the Peg3 domain become biallelic in the mutants with maternal transmission of the deletion. Expression levels of the imprinted genes were also affected in the mutants: 2-fold upregulation of Peg3 …

Do Seniors (50+) Know What Practices Are Appropriate In Physical Education, David C. Barney, Keven A. Prusak, Carol Wilkinson

Faculty Publications

The purpose of this study was to investigate senior (50+) adult’s knowledge of appropriate instructional practices (AIP) in physical education. This study is a continued line of studies assessing certain populations knowledge of AIP. Previous research has been conducted among Physical Education Teacher Education (PETE) majors, parents, school administrators, elementary, middle school and high school students. For this study 372 senior adults were surveyed regarding their knowledge of AIP in PE. Surveys were distributed to the participants at the Huntsman Senior World Games. It was found that senior adults misidentified nine instructional practices from the survey. It was found that …

Pilot Test Results Of A Video-Based Hiv Intervention For Chinese College Students In The United States, Wei-Chen Tung, Minggen Lu, Rudolph Rull, Wei Yang

Faculty Publications

Background: No culturally relevant and appropriate HIV/sexually transmitted infection (STI) programs are available to Chinese college students in the United States. This study evaluated the effectiveness of a translated Center for Disease Control and Prevention (CDC) intervention, Video Opportunities for Innovative Condom Education and Safer Sex (VOICES), to change condom use intention and self-efficacy, perceived benefits and barriers, and HIV/AIDS knowledge among Chinese students in a U.S. university. The VOICES program includes video viewing and a facilitated small-group discussion.

Methods: A quasi-experimental design with single-group pretest-posttest was conducted in Chinese. Chinese students (N=67) from a local university were recruited to …

Teaching Stats For Data Science, Daniel Kaplan

Faculty Publications

“Data science” is a useful catchword for methods and concepts original to the field of statistics, but typically being applied to large, multivariate, observational records. Such datasets call for techniques not often part of an introduction to statistics: modeling, consideration of covariates, sophisticated visualization, and causal reasoning. This article re-imagines introductory statistics as an introduction to data science and proposes a sequence of 10 blocks that together compose a suitable course for extracting information from contemporary data. Recent extensions to the mosaic packages for R together with tools from the “tidyverse” provide a concise and readable notation for wrangling, visualization, …

Stones And Bones: Catholic Responses To The 1812 Collapse Of The Mission Church Of Capistrano, Karin Vélez

Faculty Publications

This essay delves into the 1812 collapse of the Great Stone Church at California’s Mission of San Juan Capistrano and its aftermath to consider how early modern Catholics in the greater Iberian world approached the material remains of ruined churches that contained human victims. Questions explored include how Franciscan missionaries reported and reacted to the calamity, why the casualties were disproportionately Indian and female, and what survivors did with the physical remnants of broken churches. Churches that collapsed on worshippers in Arequipa, Cuzco, Lima and Lisbon prior to 1812 are mustered for comparison. Overall, a pattern emerges of Catholics separating …

Telling The Story: National And Local Soc Evaluation, Betty Walton, Isaac Karikari, Christine Marie Bishop

Faculty Publications

With foundation and grant funding for behavioral health, social services, and integrated health initiatives come requirements to collect and report data. State and local grantees, partners, and stakeholders can combine such requirements with local quality improvement and evaluation initiatives to tell their story and to manage initiatives. To support local system of care (SOC) coordinators in collecting and using grant and relevant information, basic grant requirements are reviewed in the context of using the information to support decisions, to monitor progress, and to improve outcomes.

Hospitalization Rates And Predictors Of Rehospitalization Among Individuals With Advanced Cancer In The Year After Diagnosis, Robin Whitney, Janice Bell, Daniel Tancredi, Patrick Romano, Richard Bold, Jill Joseph

Faculty Publications

PurposeAmong individuals with advanced cancer, frequent hospitalization increasingly is viewed as a hallmark of poor-quality care. We examined hospitalization rates and individual- and hospital-level predictors of rehospitalization among individuals with advanced cancer in the year after diagnosis.MethodsIndividuals diagnosed with advanced breast, colorectal, non–small-cell lung, or pancreatic cancer from 2009 to 2012 (N = 25,032) were identified with data from the California Cancer Registry (CCR). After linkage with inpatient discharge data, multistate and log-linear Poisson regression models were used to calculate hospitalization rates and to model rehospitalization in the year after diagnosis, accounting for survival.ResultsIn the year after diagnosis, 71% of …

Classifying And Predicting Occupational Incident Severity, Fatemeh Davoudi Kakhki, Steven Freeman, Gretchen Mosher

Faculty Publications

The focus of the study is to build a predictive model and assess its performance in classifying the financial severity of occupational injuries in agribusiness bulk storage facilities (i.e. grain elevators). The data specifically look at food processing and feed milling operations within these facilities. The severity of occupational injuries is determined by the total dollar amount incurred on medical costs, indemnity costs and other expenses in workers’ compensation claims. The data is available from an agribusiness insurance provider in Midwest USA. First, the most important independent variables that affect the total cost of claims are extracted from the original …

Taxing Systemic Risk, Eric D. Chason

Faculty Publications

A tax on the harmful elements of finance—a tax on systemic risk—would raise revenue and also lower the likelihood of future crisis. Financial institutions, which pay the tax, would try to minimize its cost by lowering their systemic risk. In theory, a tax on systemic risk is perfect policy. In practice, however, this perfect policy is unattainable. Tax laws need clear definitions to be administrable. Our current understanding of systemic risk is too abstract and too metaphorical to serve as a target for taxation.

Despite the absence of a clear definition of systemic risk, academics and policy makers continue to …

Diversity Of Arthropods In Farmed Wetlands In The Gulf Of Mexico Coastal Plain And Effects Of Detrital Subsidies, Nathan Mercer, Michael D. Kaller, Michael J. Stout

Faculty Publications

© 2016 The Author(s). Wetland acreage has declined continentally in the USA. With the loss of natural wetlands, farmed wetlands may be a surrogate for natural wetlands. Seasonally, flooded rice fields are commonly managed wetlands on the Gulf of Mexico Coastal Plain. This study had two objectives: (1) catalog arthropod diversity in rice fields; (2) investigate if detrital subsidies could elicit trophic cascades that reduce nuisance organisms. In 2013 and 2014, experimental rice plots were established, and detritus was applied to half of the plots in each year. Floating pitfall traps, aquatic D-net sweeping, Gee crawfish traps and root/sediment corers …

Cysteines And N-Glycosylation Sites Conserved Among All Alphaherpesviruses Regulate Membrane Fusion In Herpes Simplex Virus 1 Infection, Paul J.F. Rider, Misagh Naderi, Scott Bergeron, Vladimir N. Chouljenko, Michal Brylinski, Konstantin G. Kousoulas

Faculty Publications

© 2017 American Society for Microbiology. Neurotropism is a defining characteristic of alphaherpesvirus pathogenicity. Glycoprotein K (gK) is a conserved virion glycoprotein of all alphaherpesviruses that is not found in other herpesvirus subfamilies. The extracellular amino terminus of gK has been shown to be important to the ability of the prototypic alphaherpesvirus herpes simplex virus 1 (HSV-1) to enter neurons via axonal termini. Here, we determined the role of the two conserved N-linked glycosylation (N48 and N58) sites of gK in virus-induced cell fusion and replication. We found that N-linked glycosylation is important to the regulation of HSV-1-induced membrane fusion …

Cysteines And N-Glycosylation Sites Conserved Among All Alphaherpesviruses Regulate Membrane Fusion In Herpes Simplex Virus 1 Infection, Paul J.F. Rider, Misagh Naderi, Scott Bergeron, Vladimir N. Chouljenko, Michal Brylinski, Konstantin G. Kousoulas

Faculty Publications

© 2017 American Society for Microbiology. Neurotropism is a defining characteristic of alphaherpesvirus pathogenicity. Glycoprotein K (gK) is a conserved virion glycoprotein of all alphaherpesviruses that is not found in other herpesvirus subfamilies. The extracellular amino terminus of gK has been shown to be important to the ability of the prototypic alphaherpesvirus herpes simplex virus 1 (HSV-1) to enter neurons via axonal termini. Here, we determined the role of the two conserved N-linked glycosylation (N48 and N58) sites of gK in virus-induced cell fusion and replication. We found that N-linked glycosylation is important to the regulation of HSV-1-induced membrane fusion …

Sanctions For Evading Maximum Page Limits On Court Filings, Douglas E. Abrams

Faculty Publications

Judge Marrero joins a growing lineup of judges who have imposed or threatened sanctions on counsel for attempting to evade court rules that set maximum page limits on briefs, memoranda, and other filings. Orders and reported opinions catalogue various strategies, including these: presenting the main text in a font smaller than the court's required font; presenting the main text with spacing less than required double spacing; using excessive footnotes, often single-spaced or in small fonts; or narrowing required margins on the sides, the top, or the bottom of pages.

Prolonged Viral Replication And Longitudinal Viral Dynamic Differences Among Respiratory Syncytial Virus Infected Infants, Monica E. Brint, Joshua M. Hughes, Aditya Shah, Chelsea R. Miller, Lisa G. Harrison, Elizabeth A. Meals, Jacqueline Blanch, Charlotte R. Thompson, Stephania A. Cormier, John P. Devincenzo

Faculty Publications

© 2017 2017 International Pediatric Research Foundation, Inc. BackgroundLongitudinal respiratory syncytial virus (RSV) dynamics have not been well studied despite the existence of factors favoring prolonged RSV replication including high mutation rates allowing rapid evolution and potential escape from immune control. We therefore measured viral load in previously RSV-naive infants over prolonged time spans.MethodsDuring 2014-2015, quantitative nasal aspirates were collected from 51 RSV-PCR+ infants. Multiple parallel assessments of viral loads were quantified at each collected time point using a well-validated real-time quantitative reverse transcriptase polymerase chain reaction assay. After observing viral load rebound phenomenon in some infants, the viral dynamics …

Dietary Factors And Fibroblast Growth Factor-23 Levels In Young Adults With African Ancestry, Dominique Kosk, Holly Kramer, Amy Luke, Pauline Camacho, Pascal Bovet, Jacob Plange Rhule, Terrence Forrester, Myles Wolf, Chris Sempos, Michal L. Melamed, Lara R. Dugas, Richard Cooper, Ramon Durazo-Arvizu

Faculty Publications

Fibroblast growth factor-23 (FGF23), a phosphaturic hormone secreted mainly by osteocytes, maintains serum phosphate levels within a tight range by promoting phosphaturia. Previous studies have mainly focused on the link between FGF23 levels and dietary intake of phosphate, but other dietary factors may also influence FGF23 levels. This cross-sectional study pooled three populations of young adults with African ancestry (452 in Chicago, IL, USA; 477 in Victoria, Seychelles; and 482 in Kumasi, Ghana) with estimated glomerular filtration rate >80 ml/min/1.73 m2 to examine the association of dietary factors based on two 24-h recalls with FGF23 levels measured using a C-terminal …

Admixture Mapping In The Hispanic Community Health Study/Study Of Latinos Reveals Regions Of Genetic Associations With Blood Pressure Traits, Tamar Sofer, Leslie J. Baier, Sharon R. Browning, Timothy A. Thornton, Gregory A. Talavera, Sylvia Wassertheil-Smoller, Martha L. Daviglus, Robert Hanson, Sayuko Kobes, Richard S. Cooper, Jianwen Cai, Daniel Levy, Alex P. Reiner, Nora Franceschini

Faculty Publications

Admixture mapping can be used to detect genetic association regions in admixed populations, such as Hispanics/Latinos, by estimating associations between local ancestry allele counts and the trait of interest. We performed admixture mapping of the blood pressure traits systolic and diastolic blood pressure (SBP, DBP), mean arterial pressure (MAP), and pulse pressure (PP), in a dataset of 12,116 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos have three predominant ancestral populations (European, African, and Amerindian), for each of which we separately tested local ancestry intervals across the genome. We identified four regions that were significantly associated with …

Unravelling The Relative Contribution Of Dissolved Carbon By The Red River To The Atchafalaya River, Yi Jun Xu, Emily Marie Delduco

Faculty Publications

The Atchafalaya River (AR), North America's largest swamp river, annually discharges a large volume of freshwater (nearly 200 km3), delivering ~25% of the Mississippi River's (MR) flow and the entire Red River's (RR) flow into the Gulf of Mexico. Studies have reported higher levels of organic carbon in the AR's outlets compared to the MR's outlet, raising questions about local carbon sources. In this study, we investigated dissolved organic carbon (DOC) and dissolved inorganic carbon (DIC) inputs into the AR from the RR and MR using DOC and DIC concentrations, mass loading, and isotopic signature (δ13C) analyses. Monthly river water …

Organizational Learning In An Orthopaedic Unit: A Learning History, Bret Lyman, Lindsey Shaw, Carly Moore

Faculty Publications

The purpose of this study was to explore organizational learning in an orthopaedic hospital unit. Skill in organizational learning is necessary to achieve high reliability in a dynamic healthcare environment, yet organizational learning in hospital units is not well understood. A learning history was conducted with a high-performing orthopaedic unit. Findings were interpreted in the context of a previous learning history conducted with a critical care unit. Despite contextual differences, each unit progressed through the same four developmental stages to achieve its current state of high reliability. On both units, psychological safety and a healthy work environment proved essential for …

Internet Gaming Disorder In Children And Adolescents, Douglas A. Gentile Phd, Kira Bailey Phd, Daphne Bavelier Phd, Jeanne Funk Brockmyer Phd, Hilarie Cash Phd, Sarah M. Coyne, Andrew Doan Md, Phd, Donald S. Grant Phd, C. Shawn Green Phd, Mark Griffiths Phd, Tracy Markle Ma, Lpc, Nancy M. Petry Phd, Sarah Prot Phd, Cosette D. Rae Msw, Florian Rehbein Phd, Michael Rich Md, Dave Sullivan Lcsw, Elizabeth Woolley Ascis, Kimberly Young Phd

Faculty Publications

The American Psychiatric Association recently included Internet gaming disorder (IGD) as a potential diagnosis, recommending that further study be conducted to help illuminate it more clearly. This paper is a summary of the review undertaken by the IGD Working Group as part of the 2015 National Academy of Sciences Sackler Colloquium on Digital Media and Developing Minds. By using measures based on or similar to the IGD definition, we found that prevalence rates range between ∼1% and 9%, depending on age, country, and other sample characteristics. The etiology of IGD is not well-understood at this time, although it appears that …

Examining The Need & Potential For Biomedical Engineering To Strengthen Health Care Delivery For Displaced Populations & Victims Of Conflict, Devika Nadkarni, Imad Elhajj, Zaher Dawy, Hala Ghattas Ph.D., Muhammad H. Zaman

Faculty Publications

Conflict and the subsequent displacement of populations creates unique challenges in the delivery of quality health care to the affected population. Equitable access to quality care demands a multi-pronged strategy with a growing need, and role, for technological innovation to address these challenges. While there have been significant contributions towards alleviating the burden of conflict via data informatics and analytics, communication technology, and geographic information systems, little has been done within biomedical engineering. This article elaborates on the causes for gaps in biomedical innovation for refugee populations affected by conflict, tackles preconceived notions, takes stock of recent developments in promising …

Post-Obit Ada Claims, Thomas Simmons

Faculty Publications

No abstract provided.

A Communal Catalogue Reveals Earth's Multiscale Microbial Diversity, Luke R. Thompson, Jon G. Sanders, Daniel Mcdonald, Amnon Amir, Joshua Ladau, Kenneth J. Locey, Robert J. Prill, Anupriya Tripathi, Sean M. Gibbons, Gail Ackermann, Jose A. Navas-Molina, Stefan Janssen, Evguenia Kopylova, Yoshiki Vazquez-Baeza, Antonio Gonzalez, James T. Morton, Siavash Mirarab, Zhenjiang Zech Xu, Lingjing Jiang, Mohamed F. Haroon, Jad Kanbar, Qiyun Zhu, Se Jin Song, Tomasz Kosciolek, Nicholas A. Bokulich, Joshua Lefler, Colin J. Brislawn, Gregory Humphrey, Sarah M. Owens, Jarrad Hampton-Marcell, Donna Berg-Lyons, Valerie Mckenzie, Noah Fierer, Jed A. Fuhrman, Aaron Clauset, Rick L. Stevens, Ashley Shade, Katherine S. Pollard, Kelly D. Goodwin, Janet K. Jansson, Jack A. Gilbert, Rob Knight, The Earth Microbiome Project Consortium

Faculty Publications

Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple …

Aquatic Nitrate Retention At River Network Scales Across Flow Conditions Determined Using Nested In Situ Sensors, Wilfred Wollheim, Gopala K. Mulukutla, C. Cook, R. O. Carey

Faculty Publications

Nonpoint pollution sources are strongly influenced by hydrology and are therefore sensitive to climate variability. Some pollutants entering aquatic ecosystems, e.g., nitrate, can be mitigated by in‐stream processes during transport through river networks. Whole river network nitrate retention is difficult to quantify with observations. High frequency, in situ nitrate sensors, deployed in nested locations within a single watershed, can improve estimates of both nonpoint inputs and aquatic retention at river network scales. We deployed a nested sensor network and associated sampling in the urbanizing Oyster River watershed in coastal New Hampshire, USA, to quantify storm event‐scale loading and retention at …

Combating Subclonal Evolution Of Resistant Cancer Phenotypes, Samuel W. Brady, Jasmine A. Mcquerry, Yi Qiao, Stephen Piccolo, Gajendra Shrestha, David F. Jenkins, Ryan M. Layer, Brent S. Pedersen, Ryan H. Miller, Amanda Esch, Sara R. Selitsky, Joel S. Parker, Layla A. Anderson, Brian K. Dalley, Rachel E. Factor, Chakravarthy B. Reddy, Jonathan P. Boltax, Dean Li, Philip J. Moos, Joe W. Gray, Laura M. Heiser, Saundra S. Buys, Adam L. Cohen, W. Evan Johnson, Aaron R. Quinlan, Gabor Marth, Theresa L. Werner, Andrea H. Bild

Faculty Publications

Metastatic breast cancer remains challenging to treat, and most patients ultimately progress on therapy. This acquired drug resistance is largely due to drug-refractory sub-populations (subclones) within heterogeneous tumors. Here, we track the genetic and phenotypic subclonal evolution of four breast cancers through years of treatment to better understand how breast cancers become drug-resistant. Recurrently appearing post-chemotherapy mutations are rare. However, bulk and single-cell RNA sequencing reveal acquisition of malignant phenotypes after treatment, including enhanced mesenchymal and growth factor signaling, which may promote drug resistance, and decreased antigen presentation and TNF-α signaling, which may enable immune system avoidance. Some of these …