Digital Commons Network^™

Rapid Evolutionary Responses To Insecticide Resistance Management Interventions By The German Cockroach (Blattella Germanica L.), Mahsa Fardisi, Ameya D. Gondhalekar, Aaron R. Ashbrook, Michael E. Scharf

Faculty Publications

The German cockroach (Blattella germanica L.) is a worldwide pest that lives exclusively in human environments. B. germanica threatens human health by producing asthma-triggering allergens, vectoring pathogenic/antibiotic-resistant microbes, and by contributing to unhealthy indoor environments. While insecticides are essential for reducing cockroach populations and improving health outcomes, insecticide resistance has been a consistent barrier to cockroach control since the 1950s. We conducted seminal field studies to compare three insecticide resistance intervention strategies for cockroaches and evaluated resistance evolution across multiple generations. Using pre-treatment resistance assessment to drive decisions, we found that single active ingredient (AI) treatments can successfully eliminate cockroaches …

Adjective Learning In Young Typically Developing Children And Children With Developmental Language Disorder: A Retrieval-Based Approach, Laurence B. Leonard, Patricia Deevy, Jeffrey D. Karpicke, Sharon Christ, Christine Weber, Justin B. Kueser, Eileen Haebig

Faculty Publications

Purpose: There are strong retention benefits when learners frequently test themselves during the learning period. This practice of repeated retrieval has recently been applied successfully to children’s word learning. In this study, we apply a repeated retrieval procedure to the learning of novel adjectives by preschool-age children with developmental language disorder (DLD) and their typically developing (TD) peers. We ask whether the benefits of retrieval extend to children’s ability to apply the novel adjectives to newly introduced objects sharing the same characteristics as the objects used during the learning period. Method: Fourteen children with DLD (Mage = 62.64 months) and …

Winter Cover Crops Effect On Soil Moisture And Soybean Growth And Yield Under Different Tillage Systems, Bharat Sharma Acharya, Syam Dodla, Lewis A. Gaston, Murali Darapuneni, Jim J. Wang, Seema Sepat, Hari Bohara

Faculty Publications

Current agricultural systems heavily rely on intensive tillage and inorganic fertilizer inputs. This tradition increases the cost of agricultural production and negatively affects agricultural systems and environment. Conservation practices, such as cover crops (CCs) and no-till (NT), could serve as a management approach to promote soil health and agricultural sustainability. There is limited understanding of CCs effect on soil properties, crop growth and yield under different tillage systems in the humid sub-tropical region of the US. This study evaluated the effect of winter cover crops [wheat (Triticum aestivum) and hairy vetch (Vicia villosa)] and different tillage systems [NT and conventional …

Effect Of Two Digestive Enzymes And Ph On The Dsrna Of Endornaviruses Of Bell Pepper And Melon Under In Vitro Conditions, Adair Mccanless, Allison Hultgren, Cesar Escalante, Alyssa Ardt, Rodrigo A. Valverde

Faculty Publications

Purpose: The objective of this investigation was to determine the in vitro effect of two common digestive enzymes, amylase and pepsin, and pH on the integrity of the RI dsRNA of bell pepper endornavirus (BPEV) and Cucumis melo endornavirus (CmEV) evaluated by gel electrophoresis and reverse-transcription PCR (RT-PCR). Methods: We conducted experiments on the in vitro effect of two common digestive enzymes, amylase and pepsin, and pH on the structural integrity of the replicative intermediate (RI) dsRNA of bell pepper endornavirus (BPEV) and Cucumis melo endornavirus (CmEV), evaluated by gel electrophoresis and reverse-transcription polymerase chain reaction. Result: The effect of …

Development Of Milk Powder Containing Lactobacillus Plantarum Ncimb 8826 Immobilized With Prebiotic Hi-Maize Starch And Survival Under Simulated Gastric And Intestinal Conditions, Ronamae Bradford, Vondel Reyes, Franklin Bonilla, Federico Bueno, Bennett Dzandu, Chen Liu, Alexander Chouljenko, Subramaniam Sathivel

Faculty Publications

Abstract: The objectives of this study were to develop a probiotic milk powder containing Lactobacillus plantarum NCIMB 8826 immobilized with prebiotic Hi-maize starch and to analyze cell viability after spray drying and exposure to simulated gastric and intestinal conditions. Milk powders containing free L. plantarum and cells immobilized with Hi-maize starch were assessed. Powders were evaluated during storage at 4 °C for 15 days. After spray drying, at 0 and 15 days of storage both treatments had over 8 log CFU/g of viable cells and there were higher viable counts found for immobilized cells compared to free cells after 120 …

Survival And Inactivation Of Salmonella Enterica Serovar Typhimurium On Food Contact Surfaces During Log, Stationary And Long-Term Stationary Phases, Dorra Djebbi-Simmons, Wenqing Xu, Marlene Janes, Joan King

Faculty Publications

One of the most important transmission routes of foodborne pathogens is through contaminated food contact surfaces. In this study, we investigated the survival and inactivation of Salmonella enterica serovar Typhimurium on frequently used food contact surfaces in household settings, including plastic cutting board (CB), formica laminate (LA), and stainless steel (SS) surfaces. S. Typhimurium at log (6 h), stationary (24 h), or long-term stationary (LTS) (14 days) phases were evaluated. Results showed that, at medium and high microbial loads, LTS phase cells had significantly higher survivor population compared to log and stationary phase cells at 24 h after inoculation (p < 0.05). Disinfection study showed that LTS phase cells were very resilient to sodium hypochlorite when the initial microbial load was high with disinfection efficacy ranging from 26 to 35%. Scanning electron microscopy of these surfaces at 24 h after inoculation with a high microbial load revealed an early biofilm structure.

Supporting Confidence And Participation For People With Aphasia Through Student Interaction: A Descriptive Study On The Effects Of An Interdisciplinary Campus Program, Tyson G. Harmon, Mei-Ling Lin, Gabrille Scronce, Adam Jacks

Faculty Publications

PURPOSE: Decreased social participation is one consequence of aphasia that can lead to poor psychological health and reduced quality of life. Involving people with aphasia in advocacy efforts may be one solution for increasing their social participation. The present study investigated the benefits of a campus program for three people with mild aphasia who were involved in educating allied health students about aphasia and training them to communicate with those who have aphasia. METHODS: Three participants with aphasia shared their stories and interacted with interdisciplinary students in two seminar sessions aimed at educating students about aphasia and helping them learn …

Results From A 14-Year Intervention Program Designed To Impact Pursuit Of A Phd In Research Among Underrepresented Students In Stem Disciplines, Gretchen Schneider Burton, Eugene Kennedy, Maria Da Graça H. Vicente

Faculty Publications

Minority research and training (MRT) programs have been used across U.S. colleges and universities as a method to close the educational achievement gap and generate a highly skilled and diverse workforce. Previous studies have improved our understanding of the need to diversify the science, technology, engineering and mathematics (STEM) disciplines and the various interventions that have been developed to support these efforts. However, there is still little evidence about what strategies are most effective in promoting interest, continuation, and matriculation into STEM graduate programs among underrepresented groups. The study herein utilized a case study design with a mixed methods approach …

Using Information Practices Of Nurses To Reform Information Literacy Instruction In Baccalaureate Nursing Programs, Anne R. Diekema, Betsy S. Hopkins, Brandon Patterson, Nena Schvaneveldt

Faculty Publications

Objective - Seeking information is a key element of evidence based practice and successful healthcare delivery. Significant literature exists on both the information seeking behaviour of professional nurses and information literacy teaching methods, but scarce evidence connects nurses’ information behaviour and environments with their education. This study sought to use data from nursing alumni to answer the following research questions: What are the current information practices of professional bachelor’s-prepared nurses? How do recently-graduated nurses suggest that their education could have better prepared them to find and evaluate information in the workplace?

Methods - The researchers conducted a descriptive study using …

Evaluation Of Detached Strawberry Leaves For Anthracnose Disease Severity Using Image Analysis And Visual Ratings, Melinda A. Miller-Butler, Barbara J. Smith, Kenneth J. Curry, Eugene K. Blythe

Faculty Publications

Inoculation of detached strawberry leaves with Colletotrichum species may provide an accurate, rapid, nondestructive method of identifying anthracnose-resistant germplasm. The purpose of this study was to statistically compare two methods (visual and image analysis) of evaluating disease severity of strawberry germplasm screened for anthracnose resistance. Detached leaves of 77 susceptible and resistant strawberry clones were inoculated with one Colletotrichum gloeosporioides (Penz.) Penz. & Sacc. and two C. fragariae A. N. Brooks isolates. Anthracnose disease symptoms on each leaf were assessed quantitatively via computer-based image analysis to determine percentage lesion area and qualitatively by two independent raters using a visual disease …

Virtual Briefing At The Supreme Court, Jeffrey L. Fisher, Allison Orr Larsen

Faculty Publications

The open secret of Supreme Court advocacy in a digital era is that there is a new way to argue to the Justices. Today's Supreme Court arguments are developed online: they are dissected and explored in blog posts, fleshed out in popular podcasts, and analyzed and re-analyzed by experts who do not represent the parties or have even filed a brief in the case at all. This "virtual briefing" (as we call it) is intended to influence the Justices and their law clerks but exists completely outside of traditional briefing rules. This article describes virtual briefing and makes a case …

Pay Now, Play Later?: Youth And Adolescent Collision Sports, Vivian E. Hamilton

Faculty Publications

The routine and repeated head impacts experienced by athletes in a range of sports can inflict microscopic brain injuries that accumulate over time, even in the absence of concussion. Indeed, cumulative exposure to head impacts—not number of concussions—is the strongest predictor of sports-related degenerative brain disease in later life. The observable symptoms of disease appear years or decades after initial injury and resemble those of other mental-health conditions such as depression and dementia. The years-long interval between earlier, seemingly minor, head impacts and later brain disease has long obscured the connection between the two.

Risk of injury differs across demographics, …

Mapping The Landscape Of Support And Safety Among Sexual Minority Women And Gender Non-Conforming Individuals: Perceptions After The 2016 Us Presidential Election, Laurie Drabble, Cindy Veldhuis, Angie Wootton, Ellen Riggle, Tonda Hughes

Faculty Publications

As part of a larger online survey, we conducted an Internet-based study that included both qualitative and quantitative data from a national non-probability sample to examine how sexual minority women and gender non-conforming individuals described their experiences and concerns after the 2016 election. The current study explores responses in relation to local social and political climates. Quantitative analysis of survey responses (N = 969) examined changes in participant concerns relative to state policy context (number of positive policies offering equal rights and protections for LGBTQ communities) and size of community (e.g., urban and rural). Analysis of narrative responses to open-ended …

Strategies To Assist Distance Doctoral Students In Completing Their Dissertations, Janine M. Lim, Duane Covrig, Shirley Freed, Becky De Oliveira, Mordekai Ochieng Ongo, Isadore Newman, Isadore Newman Phd

Faculty Publications

Completing doctoral dissertations is difficult work and may be harder for distance students physically separated from institutional and collegial supports. Inability to complete independent research contributes to doctoral student attrition. Factors impacting completion include institutional factors, student characteristics, and supervisory arrangements (Manathunga, 2005). This paper shares proactive strategies used by a Midwestern university in the United States to support distance doctoral students. Strategies and technology tools are described that (a) cultivate a shared culture of responsibility and commitment, (b) increase effective communication between researchers, and (c) grow departmental and institutional services and technologies for faculty and students. This paper suggests …

Soluble Immune Checkpoint-Related Proteins As Predictors Of Tumor Recurrence, Survival, And T Cell Phenotypes In Clear Cell Renal Cell Carcinoma Patients, Qinchuan Wang, Jinhua Zhang, Huakang Tu, Dong Liang, David W. Chang, Yuanqing Ye, Xifeng Wu

Faculty Publications

Background: Immune checkpoint inhibitors have achieved unprecedented success in cancer immunotherapy. With the exception of a few candidate biomarkers, the prognostic role of soluble immune checkpoint-related proteins in clear cell renal cell cancer (ccRCC) patients is largely uninvestigated. Methods: We profiled the circulating levels of 14 immune checkpoint-related proteins panel (BTLA, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, PD-L2, Tim-3, CD28, CD80, CD137, CD27 and CTLA-4) and their associations with the risk of recurrence and death in 182 ccRCC patients using a multiplex Luminex assay. Gene expression in tumors from a subset of participating patients (n = 47) and another 533 …

Isotopic Characterization Of Nitrogen Oxides (Nox), Nitrous Acid (Hono), And Nitrate (Pno3−) From Laboratory Biomass Burning During Firex, Jiajue Chai, David J. Miller, Eric Scheuer, Jack E. Dibb, Vanessa Selimovic, Robert Yokelson, Kyle J. Zarzana, Steven S. Brown, Abigail R. Koss, Carsten Warneke, Meredith Hastings

Faculty Publications

New techniques have recently been developed and applied to capture reactive nitrogen species, including nitrogen oxides (NOx=NO+NO2), nitrous acid (HONO), nitric acid (HNO3), and particulate nitrate (pNO−3), for accurate measurement of their isotopic composition. Here, we report – for the first time – the isotopic composition of HONO from biomass burning (BB) emissions collected during the Fire Influence on Regional to Global Environments Experiment (FIREX, later evolved into FIREX-AQ) at the Missoula Fire Science Laboratory in the fall of 2016. We used our newly developed annular denuder system (ADS), which was verified to completely capture HONO associated with BB in …

Testing An Active Intervention To Deter Researchers' Use Of Questionable Research Practices, Samuel V. Bruton, M. Brown, Donald Sacco, R. Didlake

Faculty Publications

Introduction: In this study, we tested a simple, active “ethical consistency” intervention aimed at reducing researchers’ endorsement of questionable research practices (QRPs).

Methods: We developed a simple, active ethical consistency intervention and tested it against a control using an established QRP survey instrument. Before responding to a survey that asked about attitudes towards each of fifteen QRPs, participants were randomly assigned to either a consistency or control 3–5-min writing task. A total of 201 participants completed the survey: 121 participants were recruited from a database of currently funded NSF/NIH scientists, and 80 participants were recruited from a pool …

Alu Insertion Polymorphisms Shared By Papio Baboons And Theropithecus Gelada Reveal An Intertwined Common Ancestry, Jerilyn A. Walker, Vallmer E. Jordan, Jessica M. Storer, Cody J. Steely, Paulina Gonzalez-Quiroga, Thomas O. Beckstrom, Lydia C. Rewerts, Corey P. St. Romain, Catherine E. Rockwell, Jeffrey Rogers, Clifford J. Jolly, Miriam K. Konkel, Mark A. Batzer, R. Alan Harris, Muthuswamy Raveendran, Yue Liu, Shwetha Murali, Tauras P. Vilgalys, Gregg W.C. Thomas, Kymberleigh A. Pagel, Vikas Pejaver, Claudia R. Catacchio, Nicoletta Archidiacono, Mario Ventura, Alessia Marra-Campanale, Antonio Palazzo, Oronzo Capozzi, Archana Raja, John Huddleston, Veronica Searles Quick, Anis Karimpour-Fard, Dominik Schrempf, Marc De Manuel Montero, Konstantinos Billis

Faculty Publications

© 2019 The Author(s). Background: Baboons (genus Papio) and geladas (Theropithecus gelada) are now generally recognized as close phylogenetic relatives, though morphologically quite distinct and generally classified in separate genera. Primate specific Alu retrotransposons are well-established genomic markers for the study of phylogenetic and population genetic relationships. We previously reported a computational reconstruction of Papio phylogeny using large-scale whole genome sequence (WGS) analysis of Alu insertion polymorphisms. Recently, high coverage WGS was generated for Theropithecus gelada. The objective of this study was to apply the high-Throughput "poly-Detect" method to computationally determine the number of Alu insertion polymorphisms shared by T. …

Crystallization-Driven Self-Assembly Of Coil-Comb-Shaped Polypeptoid Block Copolymers: Solution Morphology And Self-Assembly Pathways, Naisheng Jiang, Tianyi Yu, Omead A. Darvish, Shuo Qian, Igor Kevin Mkam Tsengam, Vijay John, Donghui Zhang

Faculty Publications

Copyright © 2019 American Chemical Society. Crystallization-driven self-assembly (CDSA) of amphiphilic polymers into well-defined nanoscopic structures with different morphologies and functionalities has attracted increasing attention. Here, we investigate the CDSA of coil-comb-shaped diblock copolypeptoids, namely, poly(N-methyl glycine)-b-poly(N-decyl glycine) (PNMG-b-PNDG), in dilute methanol solution using X-ray/neutron solution scattering in conjunction with cryogenic transmission electron microscopy techniques. A series of PNMG-b-PNDGs were synthesized by sequential benzyl amine-initiated ring-opening polymerizations of the corresponding N-substituted N-carboxyanhydrides, in which the degree of polymerization and the length of the blocks were varied. The PNMG-b-PNDG polymers with a lower volume fraction of the crystalline PNDG blocks (fPNDG …

Amphiphilic Polypeptoids Rupture Vesicle Bilayers To Form Peptoid-Lipid Fragments Effective In Enhancing Hydrophobic Drug Delivery, Yueheng Zhang, Zahra Heidari, Yang Su, Tianyi Yu, Sunting Xuan, Marzhana Omarova, Yucel Aydin, Srikanta Dash, Donghui Zhang, Vijay John

Faculty Publications

Copyright © 2019 American Chemical Society. Peptoids are highly biocompatible pseudopeptidic polyglycines with designable substituents on the nitrogen atoms. The therapeutic and drug-carrying potential of these materials requires a fundamental understanding of their interactions with lipid bilayers. In this work, we use amphiphilic polypeptoids with up to 100 monomeric units where a significant fraction (26%) of the nitrogen atoms are functionalized with decyl groups (hydrophobes) that insert into the lipid bilayer through the hydrophobic effect. These hydrophobically modified polypeptoids (HMPs) insert their hydrophobes into lipid bilayers creating instabilities that lead to the rupture of vesicles. At low HMP concentrations, such …

Humanitarian Engineering Design For Health Challenges: An Inter-Faculty Service Based Learning Model, Yara Najem, Imad H. Elhajj, Zaher Dawy, Aline Germani, Hala Ghattas Ph.D., Muhammad Zaman, Youseph Yazdi

Faculty Publications

The study introduces and evaluates a unique inter-faculty service learning course as a pedagogical model that enhances students’ learning and knowledge of health problems and associated engineering intervention design for populations affected by protracted crises.

Background: With an increase in humanitarian protracted crises around the world, due to conflict and natural disasters, we are in dire need to reinvent how we educate, train, and conduct research in these environments. Engineering and Health Sciences disciplines, individually and collectively, have been working to fill the gaps and address pressing public health issues. However, courses merging those disciplines and focusing on emerging humanitarian …

Conformational Polymorphism In Organic Crystals: Structural And Functional Aspects - A Review, Bidisha Sengupta, Pradeep K. Sengupta, Romans Grant1, Matthew Beasley1, Benjamin Mason1, Tanesha Love1, Larissa Barroso9, Mariela Alvarado9, M S. Zaman

Faculty Publications

Polymorphism in organic crystals involves the formation of isomeric molecular identities. It is dependent on the structural arrangement due to inter-atomic interactions, as well as external stimuli, which include temperature, visible and UV radiation. Conformational polymorphism of organic crystalline molecules is often the result of isomerism due to the twisting and turning of angular bonds. The arrangement of the atoms supports different types of bonding mechanisms (which include hydrogen bonding) within the same compound. This, in turn, results in the formation of cis/trans configurational isomers or a proton transfer species (tautomer), having different functional properties. The conformers support the flexibility …

Are Father Depression And Masculinity Associated With Father Perceptions Of Maternal Gatekeeping?, Clare R. Thomas, Erin Kramer Holmes

Faculty Publications

Maternal gatekeeping has been associated with reductions in father involvement and can have a negative impact on the family. Few researchers, however, have focused on how characteristics of the father contribute to gatekeeping. Consequently, this brief report is focused on associations between father depression, father adherence to masculine norms, and father reports of maternal gatekeeping. We further test whether a father's adherence to traditional masculine norms interacts with the relationship between depression and father reports of maternal gatekeeping. This study adds to the current literature on both maternal gatekeeping and father mental health. Participants in this study include 2,214 fathers …

The Future Of Reef Ecosystems In The Gulf Of Mexico: Insights From Coupled Climate Model Simulations And Ancient Hot-House Reefs, Kristine L. Delong

Faculty Publications

emperatures (SST), salinity, carbonate chemistry, and acidity. Over the last half-century, some reef communities have been disappearing at an alarming pace. This study focuses on the Gulf of Mexico, where the majority of shallow coral reefs are reported to be in poor or fair condition. We analyze the RCP8.5 ensemble of the Community Earth System Model v1.2 to identify monthly-to-decadal trends in Gulf of Mexico SST. Secondly, we examine projected changes in ocean pH, carbonate saturation state, and salinity in the same coupled model simulations. We find that the joint impacts of predicted higher temperatures and changes in ocean acidification …

The Ies-R Remains A Core Outcome Measure For Ptsd In Critical Illness Survivorship Research, Megan M. Hosey, O. Joseph Bienvenu, Victor D. Dinglas, Alison E. Turnbull, Ann M. Parker, Ramona O. Hopkins, Karin J. Neufeld, Dale M. Needham

Faculty Publications

To the Editor: In response to Dr. Umberger’s comments on the Impact of Event Scale-Revised (IES-R) and the abbreviated 6-item IES (IES-6), we offer guidance about assessing post-traumatic stress disorder (PTSD) symptoms as part of the existing National Institutes of Health-funded core outcome measurement set (COMS) for clinical research in acute respiratory failure (ARF) survivors

Structural Analysis Of The Regulatory Gaf Domains Of Cgmp Phosphodiesterase Elucidates The Allosteric Communication Pathway, Richa Gupta, Yong Liu, Huanchen Wang, Christopher T. Nordyke, Ryan Z. Puterbaugh, Wenjin Cui, Krisztina Varga, Feixia Chu, Hengming Ke, Harish Vashisth, Rick H. Cote

Faculty Publications

Regulation of photoreceptor phosphodiesterase (PDE6) activity is responsible for the speed, sensitivity, and recovery of the photoresponse during visual signaling in vertebrate photoreceptor cells. It is hypothesized that the physiological differences in the light responsiveness of rods and cones may result in part from differences in the structure and regulation of the distinct isoforms of rod and cone PDE6. Although rod and cone PDE6 catalytic subunits share a similar domain organization consisting of tandem GAF domains (GAFa and GAFb) and a catalytic domain, cone PDE6 is a homodimer whereas the rod PDE6 catalytic dimer is composed of two homologous catalytic …

Adult Judges Use Heuristics When Categorizing Infants’ Naturally Occurring Responses To Others’ Emotions, Peter J. Reschke, Eric A. Walle

Faculty Publications

Inferring the motivations of others is a fundamental aspect of social interaction. However, making such inferences about infants can be challenging. This investigation examined adults’ ability to infer the eliciting event of an infant’s behavior and what information adults utilize to make such inferences. In Study 1, adult participants viewed recordings of 24-month-old infants responding to an actor’s emotional display (joy, sadness, fear, anger, or disgust) toward a broken toy and were asked to infer which emotion the actor expressed using only the infant’s behavioral responses. Importantly, videos were blurred and muted to ensure that the only information available regarding …

Testing Predictability Of Disease Outbreaks With A Simple Model Of Pathogen Biogeography, Tad Dallas, Colin J. Carlson, Timothée Poisot

Faculty Publications

Predicting disease emergence and outbreak events is a critical task for public health professionals and epidemiologists. Advances in global disease surveillance are increasingly generating datasets that are worth more than their component parts for prediction-oriented work. Here, we use a trait-free approach which leverages information on the global community of human infectious diseases to predict the biogeography of pathogens through time. Our approach takes pairwise dissimilarities between countries’ pathogen communities and pathogens’ geographical distributions and uses these to predict country–pathogen associations. We compare the success rates of our model for predicting pathogen outbreak, emergence and re-emergence potential as a function …

Systemic Toxicity Reported For Cdk8/19 Inhibitors Cct251921 And Msc2530818 Is Not Due To Target Inhibition, Mengqian Chen, Jing Li, Jiaxin Liang, Zanshé S. Thompson, Katie Kathrein, Eugenia Broude, Igor Roninson

Faculty Publications

CDK8/19 kinases, which mediate transcriptional reprogramming, have become an active target for cancer drug discovery. Several small-molecule CDK8/19 inhibitors showed in vivo efficacy and two have entered clinical trials, with no significant toxicities reported. However, Clarke et al. (eLife 2016; 5; e20722) found severe systemic toxicity associated with two potent CDK8/19 inhibitors, Cmpd3 (CCT251921) and Cmpd4 (MSC2530818), and suggested that their toxicity was due to on-target effects. Here, we compared five CDK8/19 inhibitors: Cmpd3, Cmpd4, Senexin B, 16-didehydro-cortistatin A (dCA) and 15w, in different assays. Only Cmpd4 showed striking toxicity in developing zebrafish. In cell-based assays for CDK8 and CDK19 …

The Quiet Undoing: How Regional Electricity Market Reforms Threaten Clean Energy Goals, Shelley Welton, Danny Cullenward

Faculty Publications

In a series of largely unnoticed but extremely consequential moves, two regional electricity market operators are pursuing reforms to make it more difficult for states to achieve their clean energy goals. The federal energy regulator, FERC, has already approved one such reform and ordered a second market operator to go farther in punishing state-supported clean energy resources than it had initially proposed. In this Essay, we bring to light the ways in which the intricate, technical reforms underway in regional electricity markets threaten state climate change objectives and the durability of FERC’s regional market constructs. If FERC allows private market …