Digital Commons Network^™

Emotion Regulation And Resilience In Parent–Adolescent Interactions Among Families Of Harmful Versus Non-Harmful Parental Alcohol Use, Marie Haverfield, Jennifer A. Theiss

Faculty Publications

This study applied emotion regulation theory to examine parental communication that predicts possible markers of adolescent resilience in families of harmful versus non-harmful parental alcohol use. Parent-adolescent dyads (30 with and 30 without harmful parental alcohol use) participated in video-taped interactions rated for parents' emotion coaching and emotion dismissing communication and adolescents' emotion regulation and behavioral impulsivity. Emotion coaching was positively associated with adolescent emotion regulation and behavioral impulsivity. Emotion dismissing was only positively associated with adolescent behavioral impulsivity. Adolescents in families of harmful alcohol use demonstrated more impulsivity but also showed more emotion regulation in the presence of emotion …

Parenting Paused: Pathological Video Game Use And Parenting Outcomes, Laura Stockdale, Sarah M. Coyne

Faculty Publications

For most people, playing video games is a normal recreational activity, with little disruption to gamers’ emotional, social, or physical health and well-being. However, for a small percentage of gamers, video gaming can become pathological (Fam, 2018). Substantial research has examined pathological gaming in teens and young adults (Cheng, Cheung, & Wang, 2018; Choo, Gentile, Sim, Khoo, & Liau, 2010), yet pathological gaming in adults (c.f.Holgren, 2017), especially in the context of parenthood, has been relatively ignored. The current study sought to address this limitation by studying associations between pathological gaming characteristics and parenting outcomes in a sample of men …

Cognitive Impairments And Self-Reported Sleep In Early-Stage Parkinson’S Disease With Versus Without Probable Rem Sleep Behavior Disorder, Jonathan Trout, Taylor Christiansen, M. Brooks Bulkley, Jared J. Tanner, Christopher N. Sozda, Dawn Bowers, Daniel Kay

Faculty Publications

Parkinson’s disease (PD) is associated with cognitive and sleep impairments. The presence of rapid eye movement (REM) sleep behavior disorder (RBD) symptoms may represent a worse disease prognosis for PD individuals. We investigated cognitive functioning and self-reported sleep in early-stage PD individuals with (n = 19) or without (n = 31) probable RBD. Probable RBD was defined as >5 on the REM Sleep Behavior Disorder Screening Questionnaire. Inhibition, visuospatial cognitive abilities, working memory, sustained visual attention, verbal fluency, and episodic memory were assessed. Sleep impairments were assessed using the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and …

Being Here And Now: The Benefits Of Belonging In Space And Time, Matthew Baldwin, Lucas A. Keefer

Faculty Publications

Research suggests that a sense of belonging is a critical prerequisite of happiness and well-being. While some have focused on belonging provided by relationships, other work demonstrates the value of belonging in certain places. In the current research we join these efforts to understand belonging by offering a novel framework for exploring an understudied but no less fundamental aspect of human experience—time. We situate this framework within an existential analysis of human action and test general predictions about the psychological value of experiencing a sense of belonging in time, what we call temporal rootedness. Two samples (Studies 1 …

Ethical Consistency And Experience: An Attempt To Influence Researcher Attitudes Toward Questionable Research Practices Through Reading Prompts, Samuel V. Bruton, Mitch Brown, Donald F. Sacco

Faculty Publications

Over the past couple of decades, the apparent widespread occurrence of Questionable Research Practices (QRPs) in scientific research has been widely discussed in the research ethics literature as a source of concern. Various ways of reducing their use have been proposed and implemented, ranging from improved training and incentives for adopting best practices to systematic reforms. This article reports on the results of two studies that investigated the efficacy of simple, psychological interventions aimed at changing researcher attitudes toward QRPs. While the interventions did not significantly modify researchers’ reactions to QRPs, they showed differential efficacy depending on scientists’ experience, suggesting …

Validity Study Of The R-Pla, A Resilience Scale For People Living With Hiv, Jinxiang Hu, Julianne M. Serovich, Monique J. Brown, Judy A. Kimberly, Yi-Hsin Chen

Faculty Publications

This study provides psychometric assessment of a resilience scale with a sample of women living with HIV. Baseline data were used from a longitudinal HIV disclosure study of 124 women aged between 18-63 collected between 2001 and 2004 in a large Midwestern city. The Rasch model was used to examine the psychometric properties of the resilience scale. Results indicated that the resilience instrument meets the Rasch model application assumptions. Evidence of validity suggested the resilience instrument demonstrated good item and person fit, as well as good item and person reliability. Most items showed measurement invariance across different age and racial …

José Martí: The World's Most Popular Poetry, And A Vision For The Americas, Anne O. Fountain

Faculty Publications

This chapter begins with a capsule biographical sketch that situates José Martí as an agent of decolonization. It discusses Martí's place in literature, especially Spanish American letters, his transcultural importance, his work in translation, his role in the history of Cuban–US relations, and his vision for US relations with Latin America. It demonstrates the extraordinary international reach of his most popular writing by giving close attention to how two works, a book of poetry, Simple Verses (Versos Sencillos) and an essay, “Our America” (“Nuestra América”) have come to represent him to an increasingly broad audience.

Small Molecules That Inhibit Tnf Signalling By Stabilising An Asymmetric Form Of The Trimer, James O'Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel E. Davis, David Mcmillan, Tracy Arakaki, Alex Burgin, David Fox Iii, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P. Cossins, Tim Bourne, Alastair Lawson

Faculty Publications

Tumour necrosis factor (TNF) is a cytokine belonging to a family of trimeric proteins; it has been shown to be a key mediator in autoimmune diseases such as rheumatoid arthritis and Crohn's disease. While TNF is the target of several successful biologic drugs, attempts to design small molecule therapies directed to this cytokine have not led to approved products. Here we report the discovery of potent small molecule inhibitors of TNF that stabilise an asymmetrical form of the soluble TNF trimer, compromising signalling and inhibiting the functions of TNF in vitro and in vivo. This discovery paves the way for …

How Responsiveness From A Communication Partner Affects Story Retell In Aphasia: Quantitative And Qualitative Findings, Tyson G. Harmon, Adam Jacks, Katarina L. Haley, Antoine Bailliard

Faculty Publications

Purpose: Because people with aphasia frequently interact with partners who are unresponsive to their communicative attempts, we investigated how partner responsiveness affects quantitative measures of spoken language and subjective reactions during story retell.

Method: A quantitative and a qualitative study were conducted. In study 1, participants with aphasia and controls retold short stories to a communication partner who indicated interest through supportive backchannel responses (responsive) and another who indicated disinterest through unsupportive backchannel responses (unresponsive). Story retell accuracy, delivery speed, and ratings of psychological stress were measured and compared. In study 2, participants completed semi-structured interviews about their story retell …

Analyze Informant-Based Questionnaire For The Early Diagnosis Of Senile Dementia Using Deep Learning, Fubao Zhu, Xiaonan Li, Daniel Mcgonigle, Haipeng Tang, Zhuo He, Chaoyang Zhang, Guang-Uei Hung, Pai-Yi Chu, Weihua Zhou

Faculty Publications

Objective: This paper proposes a multiclass deep learning method for the classification of dementia using an informant-based questionnaire.

Methods: A deep neural network classification model based on Keras framework is proposed in this paper. To evaluate the advantages of our proposed method, we compared the performance of our model with industry-standard machine learning approaches. We enrolled 6,701 individuals, which were randomly divided into training data sets (6030 participants) and test data sets (671 participants). We evaluated each diagnostic model in the test set using accuracy, precision, recall, and F1-Score.

Results: Compared with the seven conventional machine learning …

The Effects Of Premarital Education Promotion Policies On U.S. Divorce Rates, Tiffany L. Clyde, Jocelyn S. Wikle, Alan J. Hawkins, Spencer L. James

Faculty Publications

Currently, 10 states have enacted policies to promote premarital education and counseling. However, no research has documented whether these policies have actually decreased divorce rates in implementing states. The purpose of this study is to assess the effects of premarital education promotion policies on divorce rates. First, we conducted an implementation study to understand how well each state implemented the policy. A combination of methods was used, including reviewing the legislative documents and archival records, as well as interviewing academics and key persons knowledgeable of the legislation. Following the implementation study, we conducted an evaluation study to analyze the effects …

Child-Level Double Burden Of Malnutrition In The Mena And Lac Regions: Prevalence And Social Determinants, Hala Ghattas Ph.D., Yubraj Acharya, Zeina Jamaluddine, Moubadda Assi, Khalil El Asmar, Andrew D. Jones

Faculty Publications

Although the prevalence of obesity has rapidly increased in the low- and middle-income countries of the Middle East and North Africa (MENA) and Latin America and the Caribbean (LAC) regions, child undernutrition remains a public-health challenge. We examined region-specific sociodemographic determinants of this double burden of malnutrition, specifically, the co-occurrence of child stunting and overweight, using Demographic and Health Survey and Multiple Indicator Cluster Survey data (2003–2016) from 11 countries in the MENA (n = 118,585) and 13 countries in the LAC (n = 77,824) regions. We used multiple logistic regressions to model region-specific associations of maternal education and household …

Is There More Than One Way To Talk About Sex? A Longitudinal Growth Mixture Model Of Parent-Adolescent Sex Communication, Laura M. Padilla-Walker, Adam A. Rogers, Ryan D. Mclean

Faculty Publications

Purpose: Parents can be effective and consistent sex educators of their children, but research suggests that most parents only engage in a one-time talk about sex with their children. That being said, we know little about the potential variability in trajectories of parent-child sex communication over time. Thus, the present study took a person-centered approach to parent-child sex communication about sexual risk and explored predictors and outcomes of varying trajectories.

Methods: Participants included 468 adolescents and their parents who took part in a longitudinal study every year from ages 14e18 years (52% female, 67% white, and 33% single parents). …

Monte Carlo And Experimental Analysis Of A Novel Directional Rotating Scatter Mask Gamma Detection System, Julie V. Logan, Darren E. Holland, Larry W. Burggraf, Justin A. Clinton, Buckley E. O'Day Iii

Faculty Publications

Excerpt: This work demonstrates successful experimental operation of a prototype system to identify source direction which was modeled using a library of signals simulated using GEANT and a novel algorithm....

Chorioamnionitis: Case Definition & Guidelines For Data Collection, Analysis, And Presentation Of Immunization Safety Data, Alisa Kachikis, Linda O. Eckert, Christie Walker, Azucena Bardají, Frederick Varricchio, Heather S. Lipkind, Khady Diouf, Wan Ting Huang, Ronald Mataya, Mustapha Bittaye, Clare Cutland, Nansi S. Boghossian, Tamala Mallett Moore, Rebecca Mccall, Jay King, Shuchita Mundle, Flor M. Munoz, Caroline Rouse, Michael Gravett, Lakshmi Katikaneni, Kevin Ault, Nicola P. Klein, Drucilla J. Roberts, Sonali Kochhar, Nancy Chescheir

Faculty Publications

No abstract provided.

Neurodevelopmental Delay: Case Definition & Guidelines For Data Collection, Analysis, And Presentation Of Immunization Safety Data, Adrienne N. Villagomez, Flor M. Muñoz, Robin L. Peterson, Alison M. Colbert, Melissa Gladstone, Beatriz Macdonald, Rebecca Wilson, Lee Fairlie, Gwendolyn J. Gerner, Jackie Patterson, Nansi S. Boghossian, Vera Joanna Burton, Margarita Cortés, Lakshmi D. Katikaneni, Jennifer C.G. Larson, Abigail S. Angulo, Jyoti Joshi, Mirjana Nesin, Michael A. Padula, Sonali Kochhar, Amy K. Connery

Faculty Publications

No abstract provided.

Different Combinations Of Behavior Change Interventions And Frequencies Of Interpersonal Contacts Are Associated With Infant And Young Child Feeding Practices In Bangladesh, Ethiopia, And Vietnam, Sunny S. Kim, Phuong Hong Nguyen, Lan Mai Tran, Silvia Alayon, Purnima Menon, Edward A. Frongillo Jr.

Faculty Publications

Background: Social and behavior change communication interventions are integral to improving dietary and care practices, but evidence on the impact of the combination and intensity of these interventions in different contexts is scarce. Objectives: We examined the extent of and factors associated with intervention exposure: interpersonal communication (IPC) alone or with other interventions (i.e., mass media, community mobilization, or nutrition-sensitive agricultural activities), number of and factors associated with IPC contacts, and combinations of intervention components and number of contacts associated with infant and young child feeding (IYCF) practices. Methods: We used endline survey data from impact evaluations in Bangladesh, Ethiopia, …

Pesticide Seed Treatments Containing Neonicotinoids Have Limited Effect On Soil Microbial Community Structure Under Different Tillage Regimes, Jessica E. Mackay, Richard G. Smith, Jessica G. Ernakovich, Lukas T. Bernhardt

Faculty Publications

Pesticide seed treatments (PST) which contain fungicides and insecticides are commonly used in agriculture; however, little is known about their effect on soil microbial communities and soil health. Neonicotinoids – controversial insecticides which are common in PST – have received criticism due to potential non-target effects. While fungal pathogens need to be moderated, PST have the potential to disturb broader fungal communities which could lead to reduced nutrient cycling and poor soil health. Given the broad use of PST, their effect on soil fungi needs to be studied within the context of other agricultural management practices. For example, tillage regimes …

Why Acute Ischemic Stroke Patients In The United States Use Or Do Not Use Emergency Medical Services Transport? Findings Of An Inpatient Survey, Sudha Xirasagar, Meng-Han Tsai, Khosrow Heidari, James W. Hardin, Yuqi Wu, Robert Wronski, Dana Hurley, Edward C. Jauch, Souvik Sen

Faculty Publications

Background: Patients with acute ischemic stroke (AIS) who use emergency medical services (EMS) receive quicker reperfusion treatment which, in turn, mitigates post-stroke disability. However, nationally only 59% use EMS. We examined why AIS patients use or do not use EMS.

Methods: During 2016–2018, a convenience sample of AIS patients admitted to a primary stroke center in South Carolina were surveyed during hospitalization if they were medically fit, available for survey when contacted, and consented to participate. The survey was programed into EpiInfo with skip patterns to minimize survey burden and self-administered on a touchscreen computer. Survey questions covered symptom characteristics, …

7-Epi-Clusianone, A Multi-Targeting Natural Product With Potential Chemotherapeutic, Immune-Modulating, And Anti-Angiogenic Properties, Wesley F. Taylor, Maria Yanez, Sara E. Moghadam, Mahdi Moridi Farimani, Sara Soroury, Samad N. Ebrahimi, Marzieh Tabefam, Ehsan Jabbarzadeh

Faculty Publications

Targeted therapies have changed the treatment of cancer, giving new hope to many patients in recent years. The shortcomings of targeted therapies including acquired resistance, limited susceptible patients, high cost, and high toxicities, have led to the necessity of combining these therapies with other targeted or chemotherapeutic treatments. Natural products are uniquely capable of synergizing with targeted and non-targeted anticancer regimens due to their ability to affect multiple cellular pathways simultaneously. Compounds which provide an additive effect to the often combined immune therapies and cytotoxic chemotherapies, are exceedingly rare. These compounds would however provide a strengthening bridge between the two …

Are Physical Measures Related To Patient-Centered Outcomes In Ards Survivors?, Kitty S. Chan Phd, Lisa Aronson Friedman Scm, Victor D. Dinglas Mph, Catherine L. Hough Md, Msc, Carl Shanholtz Md, E. Wesley Ely Md, Mph, Peter E. Morris Md, Pedro A. Mendez-Tellez Md, James C. Jackson Psyd, Ramona O. Hopkins Phd, Dale M. Needham Fcpa, Md, Phd

Faculty Publications

Objective: To inform selection of physical measures for studies of ARDS survivors within 12 months of ARDS Methods: Secondary analysis of data from 6-month survivors participating in a U.S. multicenter prospective study (ARDSNet Long-Term Outcome Study [ALTOS], N=134) or a multi-site prospective study in Baltimore, MD (Improving Care of Acute Lung Injury Patients [ICAP], N=99). Physical measures, assessed at 6-month follow-up, were categorized according to the World HealthOrganization’s International Classification of Disability and Health: body functions and structures, activity, and participation. Patient-centered outcomes were evaluated at 6 and 12- months: survival, hospitalization, alive at home status, and health-related quality of …

Discrete Structure Of The Brain Rhythms, L. Perotti, J. Devito, D. Bessis, Y. Dabaghian

Faculty Publications

Neuronal activity in the brain generates synchronous oscillations of the Local Field Potential (LFP). The traditional analyses of the LFPs are based on decomposing the signal into simpler components, such as sinusoidal harmonics. However, a common drawback of such methods is that the decomposition primitives are usually presumed from the onset, which may bias our understanding of the signal’s structure. Here, we introduce an alternative approach that allows an impartial, high resolution, hands-off decomposition of the brain waves into a small number of discrete, frequency-modulated oscillatory processes, which we call oscillons. In particular, we demonstrate that mouse hippocampal LFP contain …

Development And Evaluation Of A One-Step Multiplex Real-Time Taqman® Rt-Qpcr Assay For The Detection And Genotyping Of Equine G3 And G14 Rotaviruses In Fecal Samples, Mariano Carossino, Maria E. Barrandeguy, Erdal Erol, Yanqiu Li, Udeni B. R. Balasuriya

Faculty Publications

No abstract provided.

The Promise And Peril Of Using Disability Law As A Tool For School Reform, Claire Raj

Faculty Publications

No abstract provided.

Multilevel Analysis In Rural Cancer Control: A Conceptual Framework And Methodological Implications, Whitney Zahnd, Sara L. Mclafferty, Jan M. Eberth

Faculty Publications

Rural populations experience a myriad of cancer disparities ranging from lower screening rates to higher cancer mortality rates. These disparities are due in part to individual-level characteristics like age and insurance status, but the physical and social context of rural residence also plays a role. Our objective was two-fold: 1) to develop a multilevel conceptual framework describing how rural residence and relevant micro, macro, and supra-macro factors can be considered in evaluating disparities across the cancer control continuum and 2) to outline the unique considerations of multilevel statistical modeling in rural cancer research. We drew upon several formative frameworks that …

Combinatorial Delivery Of Mirna-Nanoparticle Conjugates In Human Adipose Stem Cells For Amplified Osteogenesis, Mohammad Abu-Laban, Prakash Hamal, Julien H. Arrizabalaga, Anoosha Forghani, Asela S. Dikkumbura, Raju R. Kumal, Louis H. Haber, Daniel J. Hayes

Faculty Publications

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim It is becoming more apparent in tissue engineering applications that fine temporal control of multiple therapeutics is desirable to modulate progenitor cell fate and function. Herein, the independent temporal control of the co-delivery of miR-148b and miR-21 mimic plasmonic nanoparticle conjugates to induce osteogenic differentiation of human adipose stem cells (hASCs), in a de novo fashion, is described. By applying a thermally labile retro-Diels–Alder caging and linkage chemistry, these miRNAs can be triggered to de-cage serially with discrete control of activation times. The method relies on illumination of the nanoparticles at …

Anti-Viral Immunity In The Tumor Microenvironment: Implications For The Rational Design Of Herpes Simplex Virus Type 1 Oncolytic Virotherapy, Paul J.F. Rider, Ifeanyi K. Uche, Larissa Sweeny, Konstantin G. Kousoulas

Faculty Publications

© 2019, Springer Nature Switzerland AG. Purpose of Review: The design of novel herpes simplex type I (HSV-1)–derived oncolytic virotherapies is a balancing act between safety, immunogenicity, and replicative potential. We have undertaken this review to better understand how these considerations can be incorporated into rational approaches to the design of novel herpesvirus oncolytic virotherapies. Recent Findings: Several recent papers have demonstrated that enhancing the potential of HSV-1 oncolytic viruses to combat anti-viral mechanisms present in the tumor microenvironment leads to greater efficacy than their parental viruses. Summary: It is not entirely clear how the immunosuppressive tumor microenvironment affects oncolytic …

One Week Of Continuous Corticosterone Exposure Impairs Hepatic Metabolic Flexibility, Promotes Islet Β-Cell Proliferation, And Reduces Physical Activity In Male C57bl/6 J Mice, Susan J. Burke, Heidi M. Batdorf, Tai Yu Huang, Joseph W. Jackson, Katarina A. Jones, Thomas M. Martin, Kristen E. Rohli, Michael D. Karlstad, Tim E. Sparer, David H. Burk, Shawn R. Campagna, Robert C. Noland, Paul L. Soto, J. Jason Collier

Faculty Publications

© 2019 Elsevier Ltd Clinical glucocorticoid use, and diseases that produce elevated circulating glucocorticoids, promote drastic changes in body composition and reduction in whole body insulin sensitivity. Because steroid-induced diabetes is the most common form of drug-induced hyperglycemia, we investigated mechanisms underlying the recognized phenotypes associated with glucocorticoid excess. Male C57BL/6 J mice were exposed to either 100ug/mL corticosterone (cort) or vehicle in their drinking water. Body composition measurements revealed an increase in fat mass with drastically reduced lean mass during the first week (i.e., seven days) of cort exposure. Relative to the vehicle control group, mice receiving cort had …

Recurrent Fires Do Not Affect The Abundance Of Soil Fungi In A Frequently Burned Pine Savanna, Paige M. Hansen, Tatiana A. Semenova-Nelsen, William J. Platt, Benjamin A. Sikes

Faculty Publications

© 2019 Elsevier Ltd and British Mycological Society While the negative effects of infrequent, high-intensity fire on soil fungal abundance are well-understood, it remains unclear how the short-term history of frequent, low-intensity fire in fire-dependent ecosystems impacts abundance, and whether this history governs any abundance declines. We used prescribed fire to experimentally alter the short-term fire history of patches within a fire-frequented old-growth pine savanna over a 3 y period. We then quantified fungal abundance before and after the final fire using phospholipid fatty acid (PLFA) assays and Droplet Digital™ PCR (ddPCR). Short-term fire history largely did not affect total …

Elevated Levels Of Type 2 Respiratory Innate Lymphoid Cells In Human Infants With Severe Respiratory Syncytial Virus Bronchiolitis, Luan D. Vu, David Siefker, Tamekia L. Jones, Dahui You, Ryleigh Taylor, John Devincenzo, Stephania A. Cormier

Faculty Publications

© 2019 by the American Thoracic Society. Rationale: Studies of the immune responses at the site of respiratory syncytial virus (RSV) infection are sparse despite nearly five decades of research into understanding RSV disease. Objectives: To investigate the role of mucosal innate immune responses to RSV and respiratory viral load in infants hospitalized with the natural disease. Methods: Cytokines, viral load, and type 2 innate lymphoid cell (ILC2) levels in nasal aspirates, collected within 24 hours of enrollment, from infants hospitalized with RSV infection were quantified. Measurements and Main Results: RSV severity in infants was categorized based on admission to …