Digital Commons Network^™

Developing Nutritional Component Chrysin As A Therapeutic Agent: Bioavailability And Pharmacokinetics Consideration, And Adme Mechanisms, Song Gao, Nyma Siddiqui, Imoh Etim, Ting Du, Yun Zhang, Dong Liang

Faculty Publications

Chrysin is a promising naturally occurring flavonoid mainly found in honey and propolis. Although chrysin's biological activities have been demonstrated and the mechanism of actions has been determined using in vitro and in vivo models, results from the current clinical studies were largely negative. A potential reason for chrysin's low efficacy in humans is poor oral bioavailability. In this paper, we reviewed the preclinical and clinical pharmacokinetics studies of chrysin and analyzed the mechanism of poor in vivo efficacy with emphasis on its bioavailability and ADME mechanism. Low aqueous solubility, rapid metabolism mediated by UGTs and SULT, efficient excretion through …

The Therapeutic Potential Of The Novel Angiotensin-Converting Enzyme 2 In The Treatment Of Coronavirus Disease-19, Ademola Adetokunbo Oyagbemi, Temitayo Olabisi Ajibade, Yapo Guillaume Aboua, Idayat Titilayo Gbadamosi, Aduragbenro Deborah A. Adedapo, Abimbola Obemisola Aro, Olumuyiwa Abiola Adejumobi, Emma Thamahane-Katengua, Temidayo Olutayo Omobowale, Olufunke Olubunmi Falayi, Taiwo Olaide Oyagbemi, Blessing Seun Ogunpolu, Fasilat Oluwakemi Hassan, Iyanuoluwa Omolola Ogunmiluyi, Olufunke Eunice Ola-Davies, Adebowale Benard Saba, Adeolu Alex Adedapo, Sanah Malomile Nkadimeng, Lyndy Joy Mcgaw, Prudence Ngalula Kayoka-Kabongo, Momoh Audu Yakubu

Faculty Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). This virus has become a global pandemic with unprecedented mortality and morbidity along with attendant financial and economic crises. Furthermore, COVID-19 can easily be transmitted regardless of religion, race, sex, or status. Globally, high hospitalization rates of COVID-19 patients have been reported, and billions of dollars have been spent to contain the pandemic. Angiotensin-converting enzyme (ACE) 2 is a receptor of SARS-CoV-2, which has a significant role in the entry of the virus into the host cell. ACE2 is highly expressed in the type …

Anticipating And Adapting To The Future Impacts Of Climate Change On The Health, Security And Welfare Of Low Elevation Coastal Zone (Lecz) Communities In Southeastern Usa, Thomas Allen, Joshua Behr, Anamaria Bukvic, Ryan S.D. Calder, Kiki Caruson, Charles Connor, Christopher D’Elia, David Dismukes, Robin Ersing

Faculty Publications

No abstract provided.

Robustness Analysis Framework For Computations Associated With Building Performance Models And Immersive Virtual Experiments, Chanachok Chokwitthaya, Yimin Zhu, Supratik Mukhopadhyay

Faculty Publications

Building performance models (BPMs) have been used to simulate and analyze building performance during design. While extensive research efforts have made to improve the performance of BPMs, little attention has given to their robustness. Uncertainty is a crucial factor affecting the robustness of BPMs, in which such effect needs to be quantified through a suitable approach. The paper offers a robustness analysis framework for BPMs by using perturbation techniques to simulate uncertainty in input datasets. To investigate the efficacy of the framework, a generative adversarial network (GAN)-based framework was selected as a case study to analyze light switch usages in …

Crisis, Rupture And Structural Change: Re-Imagining Global Learning And Engagement While Staying In Place During The Covid-19 Pandemic, Shruti Rana, Hamid Ekbia

Faculty Publications

The COVID-19 pandemic led to unprecedented closures of national borders and the withdrawal of much of the social and cultural activities of society into the walls of the home. For us, educators focused on global engagement and analyzing international law and society, the abrupt retreat into the shelter of domestic walls disrupted the very subjects we were studying-inside and outside the classroom. In the pandemic 's first wave, most study abroad and international experiential programs were cancelled indefinitely, and the programs that continued had to operate in an environment of social distancing and uncertainty. We were forced to scramble to …

Democracy Avoidance In Tax Lawmaking, Clint G. Wallace

Faculty Publications

The Tax Cuts and Jobs Act was the most significant tax law in more than three decades, but the strategy for getting it enacted included a variety of maneuvers to avoid public scrutiny. As a result, many taxpayers did not know how they would be affected until they filed their own tax returns more than a year later. This Article identifies this lack of transparency as part of a persistent pathology of avoiding and constraining democratic inputs and responsiveness in U.S. federal tax lawmaking. Indeed, some scholars and policy makers have sought to channel tax lawmaking away from democratically grounded …

Predictors Of Complementary Feeding Practices Among Children Aged 6–23 Months In Five Countries In The Middle East And North Africa Region, Linda Shaker-Berbari, Vilma Qahoush Tyler, Chaza Akik, Zeina Jamaluddine, Hala Ghattas Ph.D.

Faculty Publications

Ensuring diets of children aged 6–23 months meet recommended guidance is crucial for growth and development and for the prevention of malnutrition including stunting, wasting and micronutrient deficiencies. Despite some improvement, indicators related to undernutrition and overnutrition fall short of global targets in the Middle East and North Africa (MENA) region that consist of low- and middle-income countries witnessing political and social changes and a nutrition transition. This research aims at reviewing the situation related to the diets of children aged 6–23 months in five selected countries in the MENA region, examining factors affecting complementary feeding and providing recommendations for …

Placental Adaptation To Maternal Malnutrition, M. Carey Satterfield, Ashley K. Edwards, Fuller W. Bazer, Kathrin A. Dunlap, Chelsie B. Steinhauser, Guoyao Wu

Faculty Publications

Maternal malnutrition gives rise to both short- and long-term consequences for the survival and health of the offspring. As the intermediary between mother and fetus, the placenta has the potential to interpret environmental signals, such as nutrient availability, and adapt to support fetal growth and development. While this potential is present, it is clear that at times placental adaptation fails to occur resulting in poor pregnancy outcomes. This review will focus on placental responses to maternal undernutrition related to changes in placental vascularization and hemodynamics and placental nutrient transport systems across species. While much of the available literature describes placental …

Nest Survival Of Seaside Sparrows (Ammospiza Maritima) In The Wake Of The Deepwater Horizon Oil Spill, Megan E. Hart, Anna Perez-Umphrey, Philip C. Stouffer, Christine Bergeon Burns, Andrea Bonisoli-Alquati, Sabrina S. Taylor, Stefan Woltmann

Faculty Publications

In 2010, the Deepwater Horizon oil spill released an estimated 4.9 million barrels of oil into the Gulf of Mexico, damaging coastal ecosystems. Seaside Sparrows (Ammospiza maritima)—a year-round resident of Gulf Coast salt marshes—were exposed to oil, as shown by published isotopic and molecular analyses, but fitness consequences have not been clarified. We monitored nests around two bays in Plaquemines Parish, Louisiana, USA from 2012–2017 to assess possible impacts on the nesting biology of Seaside Sparrows. A majority of nests failed (76% of known-fate nests, N = 252 nests, 3521 exposure-days) during our study, and predation was the main cause …

Carcass Yields And Physical-Chemical Meat Quality Characteristics Of Namibian Red Hartebeest (Alcelaphus Buselaphus) As Influenced By Sex And Muscle, Louwrens C. Hoffman, Diana L. Van Schalkwyk, Magdalena Muller, Tersia Needham, Kenneth W. Mcmillin

Faculty Publications

This study determined the carcass yields of red hartebeest from Namibia and compared the physical-chemical meat quality characteristics of six different muscles (biceps femoris, infraspinatus, longissimus thoracis et lumborum, semimembranosus, semitendinosus, and supraspinatus) for both males and females. Red hartebeest males were heavier (133.92 kg) than females (114.20 kg) but the average dressing percentage did not differ between the two sexes. Muscles from females had a lower mean shear force value of 3.59 kg/1.27 cm ø, compared to males (4.23 kg/1.27 cm ø). The most tender muscle was the infraspinatus of the female treatment group, while the semimembranosus of the …

Prolonged Time From Diagnosis To Breast-Conserving Surgery Is Associated With Upstaging In Hormone Receptor-Positive Invasive Ductal Breast Carcinoma, Natalie Hills, Macall Leslie, Rachel Davis, Marielle Crowell, Hiroyasu Kameyama, Hallgeir Rui, Inna Chervoneva, William Dooley, Takemi Tanaka

Faculty Publications

BACKGROUND: Time to surgery (TTS) has been suggested to have an association with mortality in early-stage breast cancer. OBJECTIVE: This study aims to determine the association between TTS and preoperative disease progression in tumor size or nodal status among women diagnosed with clinical T1N0M0 ductal breast cancer. METHODS: Women diagnosed with clinical T1N0M0 ductal breast cancer who had breast-conserving surgery as their first definitive treatment between 2010 and 2016 (n = 90,405) were analyzed using the National Cancer Database. Separate multivariable logistic regression models for hormone receptor (HR)-positive and HR-negative patients, adjusted for clinical and demographic variables, were used to …

Atlas Of Receptor Genes Expressed By The Bovine Morula And Corresponding Ligand-Related Genes Expressed By Uterine Endometrium, Lei Sang, Yao Xiao, Zongliang Jiang, Niamh Forde, Xiuchun Cindy Tian, Patrick Lonergan, Peter J. Hansen

Faculty Publications

Regulation of the mammalian embryo involves cell-signaling molecules produced by the maternal oviduct and endometrium. Here, datasets on the transcriptome of the gestational Days 5 and 6 bovine morula and Day 5 maternal endometrium were examined to identify receptor genes expressed by the morula and expression of the corresponding ligand-related genes in the endometrium. A total of 175 receptor genes were identified in the morula, including 48 encoding for growth factors or WNT signaling molecules, 25 for cytokines and chemokines, 35 involved in juxtacrine and matricellular signaling and 25 encoding for receptors for small molecules. Some of the highly-expressed pairs …

Biblical Social Justice And Ethical Leadership: A Pastoral Perspective, Boubakar Sanou

Faculty Publications

No abstract provided.

Recognizing And Preventing Elder Abuse, Shannon M. Trecartin, Allison Sauceda

Faculty Publications

October is Domestic Violence Awareness month and sadly, older adults are not immune to the tragedy of abuse. Approximately one in ten Americans aged 60 and over have experienced some form of abuse or neglect reports the National Council on Aging. Yet research indicates that out of every 24 actual cases of abuse or neglect, only 1 is reported.

Shifting Satellite Control Paradigms: Operational Cybersecurity In The Age Of Megaconstellations, Carl A. Poole, Robert A. Bettinger, Mark Reith

Faculty Publications

The introduction of automated satellite control systems into a space-mission environment historically dominated by human-in-the-loop operations will require a more focused understanding of cybersecurity measures to ensure space system safety and security. On the ground-segment side of satellite control, the debut of privately owned communication antennas for rent and a move to cloud-based operations or mission centers will bring new requirements for cyber protection for both Department of Defense and commercial satellite operations alike. It is no longer a matter of whether automation will be introduced to satellite operations, but how quickly satellite operators can adapt to the onset of …

Reinvigorating A Technical Countering Weapons Of Mass Destruction Distance Learning Graduate Certificate Program, James C. Petrosky, Gaiven Varshney, Jeremy Slagley, Sara Shaghaghi

Faculty Publications

Current Countering Weapons of Mass Destruction (CWMD) demands can be divided broadly into policy and science. The science of chemical, biological, and radiological/nuclear weapons informs the limits of development, production, employment, operation, detection, risk characterization, human and material protection, and medical intervention. In short, the science of weapons of mass destruction (WMD) should precede and inform the development of policy. It is to this end that the Air Force Institute of Technology (AFIT) CWMD program was re-established, providing a technical educational option for practitioners to understand the science behind a very technically challenging subject.

Performance-Based Building System Manufacturer Selection Decision Framework For Integration Into Total Cost Of Ownership Evaluations, Sarah L. Brown, Steven J. Schuldt, Michael N. Grussing, Louis B. Bartels, Michael A. Johnson, Justin D. Delorit

Faculty Publications

Facility managers are often faced with building system procurement or replacement decisions, requiring them to select a system from among competitive manufacturers. Total cost of ownership (TCO) criteria, informed by built assets in operation in the manager’s portfolio, provides some information to select the right asset manufacturer. However, managers must also consider technical performance to complete a more comprehensive analysis. Performance can be calculated using asset parameters like condition, age, and variation in condition to aid in TCO assessments. Leveraging past research and approaches, performance is calculated using an additive model that scales each parameter using a standard normalization technique …

Enhanced Detection Of Desmoplasia By Targeted Delivery Of Iron Oxide Nanoparticles To The Tumour-Specific Extracellular Matrix, Meenu Chopra, Jiansha Wu, Yen Ling Yeow, Louise Winteringham, Tristan D. Clemons, Martin Saunders, Venkata Ramana Kotamraju, Ruth Ganss, Kirk W. Feindel, Juliana Hamzah

Faculty Publications

Diagnostic imaging of aggressive cancer with a high stroma content may benefit from the use of imaging contrast agents targeted with peptides that have high binding affinity to the extracellular matrix (ECM). In this study, we report the use of superparamagnetic iron-oxide nanoparticles (IO-NP) conjugated to a nonapeptide, CSGRRSSKC (CSG), which specifically binds to the laminin-nidogen-1 complex in tumours. We show that CSG-IO-NP accumulate in tumours, predominantly in the tumour ECM, following intravenous injection into a murine model of pancreatic neuroendocrine tumour (PNET). In contrast, a control untargeted IO-NP consistently show poor tumour uptake, and IO-NP conjugated to a pentapeptide. …

Prophecy, Sabbath And Jubilee In Puerto Rico, Nicholas Miller

Faculty Publications

No abstract provided.

Global, Regional, And National Burden Of Stroke And Its Risk Factors, 1990–2019: A Systematic Analysis For The Global Burden Of Disease Study 2019, Valery L. Feigin, Benjamin A. Stark, Catherine Owens Johnson, Gregory A. Roth, Gdiom Gebreheat Abady, Ismaeel Yunusa Ph. D., Et Al.

Faculty Publications

Background

Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels.

Methods

We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and …

Global, Regional, And National Sex-Specific Burden And Control Of The Hiv Epidemic, 1990-2019, For 204 Countries And Territories: The Global Burden Of Diseases Study 2019, Deepa Jahagirdar, Magdalene K. Walters, Amanda Novotney, Edmond D. Brewer, Tahvi D. Frank, Ismaeel Yunusa Ph.D., Et. Al.

Faculty Publications

Background The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic.

Methods To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal …

Puerto Ricans And Mexican Immigrants Differ In Their Psychological Responses To Patterns Of Lifetime Adversity, Daniel K. Cooper, Mayra Bámaca-Colbert, Eric K. Layland, Emily G. Simpson, Benjamin L. Bayly

Faculty Publications

Background Puerto Ricans and Mexican immigrants are often exposed to multiple types of adversity across their lifetime (e.g., maltreatment, household dysfunction, discrimination) and this exposure can increase the risk for adult mental health problems. Purpose The objective of this study was to (a) identify subgroups of individuals exposed to unique combinations of childhood adversity and lifetime discrimination among Puerto Ricans and Mexican immigrants, and (b) compare the prevalence of mental health problems across different risk profiles. Method We used existing data from the HCHS/SOL Sociocultural Ancillary Study. Participants included Puerto Rican (N = 402) and Mexican adults (N = 1351) …

Leveraging Collaboration And Peer Support To Initiate And Sustain A Faculty Development Program, Anneris Coria-Navia, Scott Moncrieff

Faculty Publications

In today’s impoverished higher education fiscal climate, especially considering the enormous financial implications to higher education of accommodating the changes required by the coronavirus pandemic, “nonessential” though highly important programs, such as centers for teaching and learning (CTLs), are very likely to be underfunded. In this study, we illustrate how underfunded programs can leverage peer collaboration and support to initiate productive, formal systems of assistance for faculty by describing a number of such programs developed by and/or coordinated by our CTL. Moreover, we propose that sustainable programs, especially at small liberal arts institutions, must include a strong component of peer …

Assessment Of Online Water-Soluble Brown Carbon Measuring Systems For Aircraft Sampling, Linghan Zeng, Amy P. Sullivan, Rebecca A. Washenfelder, Jack E. Dibb, Eric Scheuer, Teresa L. Campos, Joseph M. Katich, Ezra Levin, Michael A. Robinson, Rodney J. Weber

Faculty Publications

Brown carbon (BrC) consists of particulate organic species that preferentially absorb light at visible and ultraviolet wavelengths. Ambient studies show that as a component of aerosol particles, BrC affects photochemical reaction rates and regional to global climate. Some organic chromophores are especially toxic, linking BrC to adverse health effects. The lack of direct measurements of BrC has limited our understanding of its prevalence, sources, evolution, and impacts. We describe the first direct, online measurements of water-soluble BrC on research aircraft by three separate instruments. Each instrument measured light absorption over a broad wavelength range using a liquid waveguide capillary cell …

Teaching With Quantitative Data In The Social Sciences At The University Of New Hampshire: An Ithaka S+R Local Report, Patricia Condon, Eleta Exline, Louise Buckley

Faculty Publications

This exploratory study investigated the teaching practices of social science instructors at the University of New Hampshire who engage with undergraduate students using quantitative data in the classroom. The participants interviewed teach both general and discipline-specific data concepts as academic, work, and life skills. Primary challenges discussed by the participants that students face in engaging with these topics are understanding math and statistical concepts, learning new software and computing skills, limited prior exposure to data, and lack of retention of content from earlier courses. Participants addressed challenges in several ways in order to lower barriers to learning, including finding, vetting, …

How Analogizing Socio-Legal Responses To Organ Transplantation Can Further The Legalization Of Reproductive Genetic Innovation, Myrisha S. Lewis

Faculty Publications

The Nobel Foundation emphasized the significance of genetic innovation to society, science, and medicine by awarding the 2020 Nobel Prize in Chemistry to “the CRISPR/Cas9 genetic scissors.” This Article focuses on “reproductive genetic innovation,” a term that includes cytoplasmic transfer, mitochondrial transfer, and germline or heritable gene editing techniques that are all categorized as “experimental” in the United States. These techniques all use in vitro fertilization, a legal and widely available practice. Yet reproductive genetic innovation has resulted in controversy and numerous barriers including a recurring federal budget rider, threats of federal enforcement action, and the unavailability of federal funding. …

Pre-Licensure Nursing Students' Experiences Of Psychological Safety: A Qualitative Descriptive Study, Bret Lyman, Camille R. Mendon

Faculty Publications

Background: Organizational learning is essential for consistently providing safe, efficient, high-quality patient care. Psychological safety is foundational for organizational learning. For pre-licensure nursing students psychological safety is crucial for both their learning and patient safety. Understanding pre-licensure nursing students' experiences of psychological safety can guide efforts to cultivate clinical environments conducive to learning and excellent patient care.

Objectives: The objective of this study was to gain insight into pre-licensure nursing students' first-hand experiences with psychological safety in clinical settings.

Design: A qualitative, descriptive design was used for this study.

Settings: Participants were recruited from 12 different nursing programs across eight …

Nudging Humans, Brett Frischmann

Faculty Publications

Behavioral data can and should inform the design of private and public choice architectures. Choice architects should steer people toward outcomes that make them better off (according to their own interests, not the choice architects’) but leave it to the people being nudged to choose for themselves. Libertarian paternalism can and should provide ethical constraints on choice architects. These are the foundational principles of nudging, the ascendant social engineering agenda pioneered by Nobel Prize winning economist Richard Thaler and Harvard law professor Cass Sunstein.

The foundation bears tremendous weight. Nudging permeates private and public institutions worldwide. It creeps into the …

Preaching Social Justice, Hyveth Williams

Faculty Publications

No abstract provided.

Coronary Heart Disease (Chd) In Elderly Patients: Which Drug To Choose, Ticagrelor And Clopidogrel? A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Mohammed Ahmed Akkaif, Abubakar Sha'aban, Nur Aizati Athirah Daud, Ismaeel Yunusa Ph.D., Mei Li Ng, Muhamad Ali Sk Abdul Kader, Dzul Azri Mohamed Noor, Baharudin Ibrahim

Faculty Publications

Background: A new generation P2Y12 receptor inhibitor (ticagrelor) is recommended in current therapeutic guidelines to treat patients with coronary heart disease (CHD). However, it is unknown if ticagrelor is more effective than clopidogrel in elderly patients. Therefore, a systematic review was done to assess the effectiveness and safety of ticagrelor and clopidogrel in older patients with CHD to determine the appropriate antiplatelet treatment plan. Methodology: We performed a systematic review of randomized controlled trials (RCTs) to compare the effectiveness and safety of ticagrelor vs. clopidogrel in elderly patients with CHD. We selected eligible RCTs based on specified study criteria following …