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The Brady Materiality Standard, Brandon L. Garrett, Adam M. Gershowitz Feb 2026

The Brady Materiality Standard, Brandon L. Garrett, Adam M. Gershowitz

Faculty Publications

The Brady doctrine requires prosecutors to disclose all favorable and material evidence to the defense. To effectuate that rule, the U.S. Supreme Court has defined materiality as a “reasonable probability” that the evidence would have affected the outcome at trial. But apart from that definition, the Court has resisted offering any further guidance to lower courts. While far too little is known about how Brady materiality claims are actually adjudicated, there is strong evidence that courts often reject Brady claims involving withheld evidence on the grounds that the evidence was not significant enough to be material.

To examine how Brady …


Is History Precedent?, Allison Orr Larsen Feb 2026

Is History Precedent?, Allison Orr Larsen

Faculty Publications

It has been just over three years since the Supreme Court instructed lower courts to evaluate Second Amendment challenges by examining history and tradition. And it is no secret that the courts have struggled. This Article tackles a phenomenon that is born of that struggle. Overwhelmed by the task of evaluating historical claims, lower courts instead are turning to other judges as authorities on history. They are using what I call in this Article “historical precedents”—meaning language about history from an older decision that the subsequent judge then treats as authority, not as part of a legal rule but for …


Research Journal 2026: People And Places, José A. Rivera Ph.D Feb 2026

Research Journal 2026: People And Places, José A. Rivera Ph.D

Faculty Publications

José Rivera narrates his life history from adolescence into college years, university teaching, research career, publications, and ends with post-retirement service as a giving back to community. For most of his term as an academic, his research focus was on community-based organizations that he terms “peoples’ institutions”: acequia associations and mutual help societies. For data, he conducted field work in New Mexico and the American Southwest as well as internationally, primarily in Mexico, Peru, Spain and the Philippines. While at these locations, he interviewed people, collected maps, researched archives, and took photographs as ethnographic evidence of people and places. His …


The Case For An African Investment Court (Aic), Won L. Kidane Feb 2026

The Case For An African Investment Court (Aic), Won L. Kidane

Faculty Publications

No abstract provided.


Taming Psoriatic Inflammation: Targeting The Inos–Oxidative Stress–Necroptosis Axis For Precision Therapy, Tolulope Omotope Omolekan, Tithi Roy, Jean Christopher Chamcheu Jan 2026

Taming Psoriatic Inflammation: Targeting The Inos–Oxidative Stress–Necroptosis Axis For Precision Therapy, Tolulope Omotope Omolekan, Tithi Roy, Jean Christopher Chamcheu

Faculty Publications

Necroptosis is increasingly recognized as a central driver of psoriatic inflammation, promoting keratinocyte death and sustaining immune activation. Recent evidence shows that inducible nitric oxide synthase (iNOS) deficiency and exogenous nitric oxide (NO) supplementation ameliorate psoriasis-like dermatitis in mice by reducing oxidative stress and constraining necroptotic signaling. These findings identify iNOS-derived NO as both a mediator of reduction–oxidation (redox) imbalance and a key regulator of necroptosis, thereby advancing mechanistic insight into psoriatic pathogenesis. Importantly, they highlight the iNOS–oxidative stress–necroptosis axis as a translationally actionable therapeutic target. Modulating necroptotic cell death through NO-based interventions may restore epidermal homeostasis and improve clinical …


Patient-Specific Lumped-Parameter Model For Quantifying Vessel-Specific Remodeling And Predicting Right Ventricular Function In Pulmonary Hypertension, Christopher G. Lechuga, Amirreza Kachabi, Mitchel J. Colebank, Claudia E. Korcarz, Farhan Raza Jan 2026

Patient-Specific Lumped-Parameter Model For Quantifying Vessel-Specific Remodeling And Predicting Right Ventricular Function In Pulmonary Hypertension, Christopher G. Lechuga, Amirreza Kachabi, Mitchel J. Colebank, Claudia E. Korcarz, Farhan Raza

Faculty Publications

Purpose: Pulmonary hypertension (PH) is a heterogeneous disease with patient-specific variability and vessel-specific remodeling, which eventually lead to right ventricular (RV) failure. The gold standard for RV assessment—pressure–volume (PV) loop acquisition—is invasive and limited to specialized settings. This study aims to develop a patient-specific lumped-parameter model that quantifies vessel-specific remodeling and simulates RV PV loops across PH phenotypes using routine clinical data.

Methods: A lumped-parameter model was calibrated using right heart catheterization and echocardiography data. Model agreement was assessed by R2 values for pressure and flow goodness-of-fit, and model-derived hemodynamic metrics were comparedwith clinical values. A dimensionality reduction approach was …


Psychological Resilience In The Covid-19 Response: A Systematic Review For Future Public Health Preparedness, Atena Pasha, Abdul-Hanan Saani Inusah, Jannatun Nayem, Xiaoming Li, Shan Qiao Jan 2026

Psychological Resilience In The Covid-19 Response: A Systematic Review For Future Public Health Preparedness, Atena Pasha, Abdul-Hanan Saani Inusah, Jannatun Nayem, Xiaoming Li, Shan Qiao

Faculty Publications

Objective: The COVID-19 pandemic has highlighted the importance of psychological resilience for well-being. While several reviews have addressed resilience in specific populations or contexts, few have synthesized global literature across diverse populations. This review examines psychological resilience across diverse populations, focusing on measurement, associated factors, and future public health preparedness strategies. Method: Guided by the PRISMA, a thorough search of PsycINFO, PubMed, ScienceDirect, and Web of Science was conducted in February 2024, including quantitative studies considering psychological resilience during the COVID-19 pandemic published in peer-reviewed English journals from 2020 to 2024, using search terms relevant to psychological resilience and COVID-19. …


Effects Of Leucine Supplementation On Athletic Performance, Central Fatigue, And Serum Metabolism In Endurance Athletes: A Randomized Controlled Trial And Targeted Metabolomics Study, Tieying Li, Wei Xu, Jun Chen, Zhaobo Kan, Xuemei Sui, Zhiguang Zhao, Qirong Wang Jan 2026

Effects Of Leucine Supplementation On Athletic Performance, Central Fatigue, And Serum Metabolism In Endurance Athletes: A Randomized Controlled Trial And Targeted Metabolomics Study, Tieying Li, Wei Xu, Jun Chen, Zhaobo Kan, Xuemei Sui, Zhiguang Zhao, Qirong Wang

Faculty Publications

Objectives: We aimed to investigate the effects of 6 weeks of leucine supplementation on athletic performance, central fatigue, and serum metabolome in endurance athletes, and to provide valuable insights into nutritional strategies for endurance athletes. Methods: Twenty cross-country skiers were recruited and randomized into 2 groups: the placebo (PLA) group and the leucine (LEU) group. Subjects were given leucine (8.5 g) + sucrose (14 g) or only sucrose (14 g) supplements twice each day from Monday to Saturday for 6 weeks. Test parameters include body composition, aerobic capacity, isokinetic muscle strength, blood biochemistry, and targeted metabolomics. Results: After intervention, compared …


Virtual And Remote Cardiac Rehabilitation For Older Adults: Current Evidence And Implementation Strategies, Sarah E. Slone, Rita D'Aoust, Rhonda Smith Wright, Victoria A. Yandle, Kurt G. Barringhaus Jan 2026

Virtual And Remote Cardiac Rehabilitation For Older Adults: Current Evidence And Implementation Strategies, Sarah E. Slone, Rita D'Aoust, Rhonda Smith Wright, Victoria A. Yandle, Kurt G. Barringhaus

Faculty Publications

Purpose of Review

To present and analyze recent developments in remote cardiac rehabilitation for older adults, review outcomes data regarding clinical effectiveness of these modalities, and discuss implementation strategies targeted at older adults.

Recent Findings

Data from recent studies enrolling older adults into remote cardiac rehabilitation programs have yielded mixed results with some showing encouraging improvements in functional capacity and quality of life comparable to those obtained with center-based rehabilitation programs. Studies that showed no improvement in outcomes identified decreased patient engagement as an important driver of results. This underscores the importance of adapting remote cardiac rehabilitation programs to the …


Improving Lexicosemantic Impairments In Post-Stroke Aphasia Using Rtms Targeting The Right Anterior Temporal Lobe, Sophie Arheix-Parras, Sophia R. Moore, Rutvik H. Desai Jan 2026

Improving Lexicosemantic Impairments In Post-Stroke Aphasia Using Rtms Targeting The Right Anterior Temporal Lobe, Sophie Arheix-Parras, Sophia R. Moore, Rutvik H. Desai

Faculty Publications

Background/Objectives: Repetitive Transcranial Magnetic Stimulation (rTMS) can enhance post-stroke aphasia recovery. The right Inferior Frontal Gyrus is the most common target in rTMS studies for inhibitory stimulation. However, lexicosemantic processes involve a large brain network including the Anterior Temporal Lobe (ATL). We hypothesize that rTMS targeting the ATL will improve lexicosemantic impairments in people with post-stroke aphasia. Methods: In a Single-Case Experimental Design, three people with post-stroke aphasia with lexicosemantic impairments performed Picture and Auditory Naming and Semantic Decision tasks five times a week for one or two weeks to establish baseline scores. Then, each participant received continuous inhibitory Theta …


When Disasters Trigger Cyber Vulnerabilities: Mapping Physical-Digital Interdependencies In Critical Infrastructure Systems, Dikshya Panta, Sicheng Wang, Aditya Sapkota, Prakash Ranganathan Jan 2026

When Disasters Trigger Cyber Vulnerabilities: Mapping Physical-Digital Interdependencies In Critical Infrastructure Systems, Dikshya Panta, Sicheng Wang, Aditya Sapkota, Prakash Ranganathan

Faculty Publications

Critical infrastructure (CI) systems such as power, water, communications, and emergency services are increasingly exposed to compound risks in which natural disasters and cyber incidents interact and amplify one another. Traditional risk assessments often isolate physical and digital threats, overlooking the cascading dependencies that emerge when operational stress, emergency reconfiguration, and adversarial exploitation coincide. This study conducts a 2019–2025 scoping review and introduces a Geographic Information System (GIS) driven six-stage disaster cyber compounding framework that characterizes, maps, and operationalizes compound risk across interdependent CI sectors. The framework integrates a common operating picture, analytic situational understanding, exposure mapping, threat-fingerprint encoding, detection …


Dietary Inflammatory Index And Risk Of Colorectal Cancer In Japanese Men, Ayaka Kotemori, Kumiko Kito, Motoki Iwasaki, Taiki Yamaji, James Hébert Scd, Junko Ishihara, Manami Inoue, Shoichiro Tsugane, Norie Sawada On The Behalf Of Jphc Study Group Jan 2026

Dietary Inflammatory Index And Risk Of Colorectal Cancer In Japanese Men, Ayaka Kotemori, Kumiko Kito, Motoki Iwasaki, Taiki Yamaji, James Hébert Scd, Junko Ishihara, Manami Inoue, Shoichiro Tsugane, Norie Sawada On The Behalf Of Jphc Study Group

Faculty Publications

Background/Objectives: Unhealthy lifestyles lead to chronic low-grade inflammation, increasing the risk of colorectal cancer. Few studies in East Asia have examined the association between the dietary inflammation potential and colorectal cancer incidence. Therefore, we aimed to investigate this association further in the Japanese population. Methods: This study included 38,807 men aged 45–74 years who participated in the Japan Public Health Center-based prospective study (JPHC Study). The energy-adjusted dietary inflammatory index (E-DII) was derived from a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. Differences in risk due to a …


More Than A Prescription: The Need For Behavioral Theory To Guide Exercise Interventions For Osteoarthritis - A Narrative Review, Christine Pellegrini, Lisa C. Carlesso, Daniel K. White Jan 2026

More Than A Prescription: The Need For Behavioral Theory To Guide Exercise Interventions For Osteoarthritis - A Narrative Review, Christine Pellegrini, Lisa C. Carlesso, Daniel K. White

Faculty Publications

Objective

Many clinical exercise trials show that participation in exercise, such as strength training and aerobic walking, reduce osteoarthritis (OA)-related pain and functional limitation. This has led to exercise being one of the most commonly prescribed treatments for OA. However, little attention is given to the complex behavior elements of exercise, that is exercise is an activity that adults need to choose to engage in regularly, which is necessary to ensure exercise can have long-term efficacy to address pain. The purpose of this review is to highlight the behavioral aspects of exercise.

Design

Narrative review

Results

Limitations of previous clinical …


Supervised Resistance Training In An Individual With Glioblastoma Undergoing Chemoradiation: A Case Report, Bruce Nakfoor, Ciaran Fairman Ph.D., Cscs, Cet Jan 2026

Supervised Resistance Training In An Individual With Glioblastoma Undergoing Chemoradiation: A Case Report, Bruce Nakfoor, Ciaran Fairman Ph.D., Cscs, Cet

Faculty Publications

Introduction:

Exercise has demonstrated safety and efficacy in mitigating treatment-related symptoms across cancer populations; however, evidence in neuro-oncology remains limited, particularly during active chemoradiation.

Methods:

We report the case of a 63-year-old individual with newly diagnosed glioblastoma, experiencing symptoms of fatigue, balance issues, headaches, and memory loss, who initiated a 12-week supervised resistance training program during concurrent chemoradiation. Assessments at baseline and post-intervention included physical function and quality-of-life outcomes.

Results:

Adherence was 56% (20/36 sessions), and no adverse events occurred. The patient showed improvements in 6-minute walk distance and short physical performance battery score that exceeded established minimal clinically important …


Gendered Paths To Cancer Knowledge And Screening Behavior Among Black Adults: Results From A Community-Partnered Study, Carolyn M. Tucker, Guillermo M. Wippold, Kirsten G. Klein, Logan Marcum, Ji-Hyun Lee, Gonghao Liu, Staja Q. Booker, Elliott Leighton, Danielle E. Jake-Schoffman, Adrian S. Taylor, Ron Rawls, Kenyarda T. Feathers, Kevin A. Thorpe, Gwendolyn Saffo, Deborah Johnson Jan 2026

Gendered Paths To Cancer Knowledge And Screening Behavior Among Black Adults: Results From A Community-Partnered Study, Carolyn M. Tucker, Guillermo M. Wippold, Kirsten G. Klein, Logan Marcum, Ji-Hyun Lee, Gonghao Liu, Staja Q. Booker, Elliott Leighton, Danielle E. Jake-Schoffman, Adrian S. Taylor, Ron Rawls, Kenyarda T. Feathers, Kevin A. Thorpe, Gwendolyn Saffo, Deborah Johnson

Faculty Publications

Background

Efforts are needed to promote cancer knowledge and the uptake of cancer screening behaviors among Black Americans. Such efforts must be customized for the unique differences in facilitators/barriers among Black men and women. The present study leverages the potential of the UF Health Cancer Institute Community-Partnered Cancer Disparities Research Collaborative (CDRC) to identify the psychosocial and structural factors associated with cancer knowledge and screening behaviors among Black American men and women.

Method

411 Black Americans participated in this cross-sectional study; 75.9% identified as cisgender women and 24.1% as cisgender men.

Results

Older age, higher education and income level were …


Strength In Numbers: Exploring The Link Between Upper Body Muscular Strength And Academic Achievement In Youth, Julian A. Reed, Marsha Dowda Drph, Russell R. Pate Ph.D. Jan 2026

Strength In Numbers: Exploring The Link Between Upper Body Muscular Strength And Academic Achievement In Youth, Julian A. Reed, Marsha Dowda Drph, Russell R. Pate Ph.D.

Faculty Publications

Objectives

The purpose of this study was to examine the associations between upper body strength and endurance (UMSE) and academic achievement in youth.

Design

Cross-sectional study included 5th (N = 25,025) and 8th grade (N = 14,988) students in South Carolina.

Methods

Academic achievement was measured using a statewide assessment and classified into two categories (meets/exceeds standards or does not meet/approaches standards). Achievement in mathematics and English Language Arts was assessed. UMSE was measured as part of the South Carolina FitnessGram project and expressed as Healthy Fitness Zone (HFZ) or Needs Improvement – Health Risk. Student demographic characteristics were derived …


Cognitive Dysfunction In Women With The Fmr1 Premutation During Midlife: The Lassi-L Reveals Curvilinear Cgg-Dependent Risk Buffered By College Education, Jessica Klusek, Jillian Gierman, Amanda Fairchild, Andreana M. Benitez, Elizabeth Berry-Kravis, Marsha R. Mailick Jan 2026

Cognitive Dysfunction In Women With The Fmr1 Premutation During Midlife: The Lassi-L Reveals Curvilinear Cgg-Dependent Risk Buffered By College Education, Jessica Klusek, Jillian Gierman, Amanda Fairchild, Andreana M. Benitez, Elizabeth Berry-Kravis, Marsha R. Mailick

Faculty Publications

Background

The FMR1premutation (FXPM) is a common genetic variant (∼1:151 females) linked to increased risk for neurodegenerative disease. Midlife cognitive phenotypes remain poorly defined.

Objective

To characterize episodic memory performance in midlife FXPM women and examine potential risk moderation via genetic (i.e., FMR1CGG repeat expansion size) and environmental (i.e., college degree attainment) influences.

Methods

Eighty-eight FXPM women and 84 matched controls, aged 30–55, completed the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), a measure of specific episodic memory processes sensitive to subtle Alzheimer's disease (AD)-related cognitive and neuropathological changes.

Results

FXPM women demonstrated deficits in proactive semantic …


Effects Of Social Support Interventions On Medical Patient Survival: A Meta-Analysis Of Non-Randomized Clinical Trials, Ksenia Illinykh-Bair, Timothy B. Smith Jan 2026

Effects Of Social Support Interventions On Medical Patient Survival: A Meta-Analysis Of Non-Randomized Clinical Trials, Ksenia Illinykh-Bair, Timothy B. Smith

Faculty Publications

Background: Prior research confirms that social support promotes resilience among medical patients with chronic illness. Beyond emotional benefits, research has increasingly shown the importance of social support on physical health outcomes. Therefore, identifying and evaluating interventions that increase social support among medical patients with chronic conditions is a priority for healthcare. Methods: This meta-analysis summarized data from 39,493 medical patients across 14 non-randomized trials that had been identified by a prior review of the survival benefits of social support interventions. Results: Across four studies reporting hazard ratio data, the results failed to reach statistical significance (HR = 2.10, 95% CI …


Statewide Sanctuary Policies And Female Homicide Rates, 2016–2021, Kaitlin M. Boyle, Sophia Shaiman, Veronica Valencia Gonzalez, Wendy Regoeczi Jan 2026

Statewide Sanctuary Policies And Female Homicide Rates, 2016–2021, Kaitlin M. Boyle, Sophia Shaiman, Veronica Valencia Gonzalez, Wendy Regoeczi

Faculty Publications

The current study examines whether state immigration enforcement policies, such as sanctuary policies that limit local police cooperation with federal immigration enforcement, are associated with female homicide rates in the United States (2016–2021). We examine crude female homicide rates from the National Violent Death Reporting System (N = 244 state-years), which we stratify by race and ethnicity (Hispanic of all races, non-Hispanic Black, and non-Hispanic White) and victim–suspect relationship (domestic vs. stranger homicide). State-years with policies that are more protective of immigrants were not associated with higher homicide rates for any group. Instead, state-years with these policies reported significantly lower …


Fatigue Crack Length Estimation Using Acoustic Emissions Technique-Based Convolutional Neural Networks, Asaad Migot, Ahmed Saaudi, Roshan Joseph, Victor Giurgiutiu Jan 2026

Fatigue Crack Length Estimation Using Acoustic Emissions Technique-Based Convolutional Neural Networks, Asaad Migot, Ahmed Saaudi, Roshan Joseph, Victor Giurgiutiu

Faculty Publications

Fatigue crack propagation is a critical failure mechanism in engineering structures, requiring meticulous monitoring for timely maintenance. This research introduces a deep learning framework for estimating fatigue fracture length in metallic plates through acoustic emission (AE) signals. AE waveforms recorded during crack growth are transformed into time-frequency images using the Choi–Williams distribution. First, a clustering system is developed to analyze the distribution of the AE image-based dataset. This system employs a CNN-based model to extract features from the input images. The AE dataset is then divided into three categories according to fatigue lengths using the K-means algorithm. Principal Component Analysis …


Plasma Proteomic Profiling Reveals Distinct Protein Signatures Associated With Hepatocellular Carcinoma In Chronic Hepatitis B Infection, Sidnooma Véronique Zongo, Michael A. Bauer, Lassina Traore, Tegwinde Rebeca Compaore, Albert Théophane Yonli, Augustin Tozoula Bambara, Palwendé Romuald Boua, Roger Arsène Sombié, Oumar Barro, Sosthene K. Somda, Mahamoudou Sanou, Jeremy James Martinson, Jean Christopher Chamcheu, Lewis R. Roberts, Mitesh J Borad, Bolni Marius Nagalo, Alan J Tackett, Adama Sanou, Florencia Wendkuuni Djigma, Jacques Simpore Jan 2026

Plasma Proteomic Profiling Reveals Distinct Protein Signatures Associated With Hepatocellular Carcinoma In Chronic Hepatitis B Infection, Sidnooma Véronique Zongo, Michael A. Bauer, Lassina Traore, Tegwinde Rebeca Compaore, Albert Théophane Yonli, Augustin Tozoula Bambara, Palwendé Romuald Boua, Roger Arsène Sombié, Oumar Barro, Sosthene K. Somda, Mahamoudou Sanou, Jeremy James Martinson, Jean Christopher Chamcheu, Lewis R. Roberts, Mitesh J Borad, Bolni Marius Nagalo, Alan J Tackett, Adama Sanou, Florencia Wendkuuni Djigma, Jacques Simpore

Faculty Publications

Background

Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), yet reliable biomarkers for early detection and risk stratification remain limited. This study aimed to identify plasma proteins associated with disease progression from chronic HBV infection to HCC.

Methods

Plasma proteomic profiling was conducted using high-resolution LC–MS/MS on samples from healthy controls, chronic HBV carriers, patients with cirrhosis, and individuals with HBV-associated HCC. Differentially expressed proteins were identified through bioinformatics analysis, and protein–protein interaction networks were reconstructed to assess functional relevance.

Results

Eight proteins displayed distinct, stage-specific expression patterns along the disease continuum. ICAM1, TIMP1, …


Host-Derived Interleukin-1Α Drives Tumor Immunosuppression By Reprogramming Tumor-Associated Myeloid Cells, Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson, Katie Kathrein, Alissa R. Armstrong, R. Michael Gower, Igor Roninson Ph.D., Eugenia Broude, Mengqian Chen Ph.D., Hao Ji, Chang-Uk Lim, Hongjun Wang, Daping Fan, Peisheng Xu Ph.D., Hexin Chen Jan 2026

Host-Derived Interleukin-1Α Drives Tumor Immunosuppression By Reprogramming Tumor-Associated Myeloid Cells, Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson, Katie Kathrein, Alissa R. Armstrong, R. Michael Gower, Igor Roninson Ph.D., Eugenia Broude, Mengqian Chen Ph.D., Hao Ji, Chang-Uk Lim, Hongjun Wang, Daping Fan, Peisheng Xu Ph.D., Hexin Chen

Faculty Publications

Myeloid cells are highly heterogeneous and play key roles in establishing an immunosuppressive tumor microenvironment (TME), but the mechanisms controlling their differentiation remain unclear. Using orthotopic murine breast cancer models, we investigated how interleukin-1α (IL-1α) influences this process. Deletion of host Il1α resulted in rejection of transplanted tumors. Single-cell RNA sequencing identified CX3CR1⁺ macrophages as the main source of IL-1α in the TME. Il1α deficiency disrupted monocyte–macrophage differentiation, reducing CX3CR1⁺ macrophages and increasing iNOS⁺ macrophages. Myeloid cells from Il1α⁻/⁻ hosts induced lower PD-1 and CTLA-4 expression in co-cultured CD8⁺ T cells than those from wild-type hosts. CellChat analysis showed …


Access Is The Outcome: Rethinking Metrics, Worthiness, And Human Rights Across Philanthropy And Development, Stephanie Zabriskie Jan 2026

Access Is The Outcome: Rethinking Metrics, Worthiness, And Human Rights Across Philanthropy And Development, Stephanie Zabriskie

Faculty Publications

This thought paper examines how philanthropic evaluation frameworks misclassify access to basic human rights as a preliminary step rather than a complete outcome. In competitive funding environments, post-access behavioral metrics such as utilization and compliance are often elevated to outcome status and used to assess program worthiness. Drawing on rights-based and systems-level evaluation frameworks, the paper argues that access itself constitutes a sufficient and legitimate outcome, and that post-access data should function as program management inputs rather than legitimacy or financial thresholds. Reframing access as the outcome has implications for philanthropic accountability, administrative burden, and the ethical consistency of funding …


Polystyrene Nanoplastics As Pfas Carriers And Their Interactions With Zwitterionic Phospholipid Membranes, Jiahuiyu Fang, Tongxuan Qiao, Pranab Sarker, Xiaoxue Qin, Size Zheng, Mark J. Uline, Tao Wei Jan 2026

Polystyrene Nanoplastics As Pfas Carriers And Their Interactions With Zwitterionic Phospholipid Membranes, Jiahuiyu Fang, Tongxuan Qiao, Pranab Sarker, Xiaoxue Qin, Size Zheng, Mark J. Uline, Tao Wei

Faculty Publications

The co-occurrence of per- and polyfluoroalkyl substances (PFAS) and nanoplastics (NPs) poses a synergistic threat to environmental and human health, yet the molecular mechanisms governing PFAS–NP complexation and membrane interactions remain unclear. Using atomistic molecular dynamics simulations, we investigated the adsorption of neutral polytetrafluoroethylene (PTFE) and anionic perfluorinated compounds (perfluorooctanoic acid, PFOA, and perfluorooctanesulfonic acid, PFOS) on polystyrene NPs (3.1 and 6.7 nm) and their interactions with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membranes. Polystyrene NPs act as carriers, transporting PFAS molecules to the lipid/water interface, where PFAS attachment modifies NP interfacial behavior. PFAS adsorption on the NP surface is driven by …


Anoikis Resistance And Metastasis Of Ovarian Cancer Can Be Overcome By Cdk8/19 Mediator Kinase Inhibition, Mehri Monavarian, Resha Rajkarnikar, Emily Faith Page, Asha Kumari, Liz Quintero Macias, Felipe Massicano, Nam. Y. Lee, Sarthak Sahoo, Nadine Hempel, Mohit Kumar Jolly, Lara Ianov, Elizabeth Worthey, Abhyudai Singh, Igor Roninson Ph.D., Eugenia Broude Ph.D., Mengqian Chen Ph.D., Karthikeyan Mythreye Jan 2026

Anoikis Resistance And Metastasis Of Ovarian Cancer Can Be Overcome By Cdk8/19 Mediator Kinase Inhibition, Mehri Monavarian, Resha Rajkarnikar, Emily Faith Page, Asha Kumari, Liz Quintero Macias, Felipe Massicano, Nam. Y. Lee, Sarthak Sahoo, Nadine Hempel, Mohit Kumar Jolly, Lara Ianov, Elizabeth Worthey, Abhyudai Singh, Igor Roninson Ph.D., Eugenia Broude Ph.D., Mengqian Chen Ph.D., Karthikeyan Mythreye

Faculty Publications

Anoikis resistance, or evasion of cell death triggered by matrix detachment, is a hallmark of cancer cell survival and metastasis. We showed that repeated exposure to suspension stress followed by recovery under attached conditions leads to development of anoikis resistance. The acquisition of anoikis resistance was associated with enhanced invasion, chemoresistance, and immune evasion in vitro and distant metastasis in vivo. This acquired anoikis resistance was not genetic, persisting for a finite duration without detachment stress, but was sensitive to CDK8/19 mediator kinase inhibition that could also reverse anoikis resistance. Transcriptomic analysis revealed that CDK8/19 kinase inhibition induces bidirectional transcriptional …


Protocol For The Development Of The Who Gestational Weight Gain Charts, Thais Rangel Bousquet Carrilho, Olufemi Taiwo Oladapo, Jennifer A. Hutcheon, Giovanna Gatica-Domínquez, Kathleen M. Rasmussen, Monica C. Flores-Urrutia, Richard Kumapley, Ӧzge Tunçalp, Dang Bahya-Batinda, Amel A. Fayed, Annick Bogaerts, Aris T. Papageorghiou, Cinthya Muñoz-Manrique, Dayana Rodrigues Farias, Eric Ohuma, Harshpal Sachdev, Hayfaa A. Wahabi, Helena J. Teede, Molin Wang, Nandita Perumal Phd Jan 2026

Protocol For The Development Of The Who Gestational Weight Gain Charts, Thais Rangel Bousquet Carrilho, Olufemi Taiwo Oladapo, Jennifer A. Hutcheon, Giovanna Gatica-Domínquez, Kathleen M. Rasmussen, Monica C. Flores-Urrutia, Richard Kumapley, Ӧzge Tunçalp, Dang Bahya-Batinda, Amel A. Fayed, Annick Bogaerts, Aris T. Papageorghiou, Cinthya Muñoz-Manrique, Dayana Rodrigues Farias, Eric Ohuma, Harshpal Sachdev, Hayfaa A. Wahabi, Helena J. Teede, Molin Wang, Nandita Perumal Phd

Faculty Publications

Introduction Gestational weight gain (GWG) is an important indicator of maternal nutrition to be monitored during pregnancy. However, there is no evidence-based tool that can be used to monitor it across all geographic locations and pre-pregnancy body mass index (BMI) categories. The WHO is undertaking a project to develop GWG charts by pre-pregnancy BMI category, and to identify GWG ranges associated with the lowest risks of adverse maternal and infant outcomes. This protocol describes all the steps that will be used to accomplish the development of these GWG charts.

Methods and analysis This project will involve the analysis of individual …


Molecular Survival Strategies Against Kidney Filtration: Implications For Therapeutic Protein Engineering, William Heaps, Anna Elise Packard, Kristina M. Mccammon, Tyler P. Green, Joseph P. Talley, Bradley C. Bundy, Dennis Della Corte Jan 2026

Molecular Survival Strategies Against Kidney Filtration: Implications For Therapeutic Protein Engineering, William Heaps, Anna Elise Packard, Kristina M. Mccammon, Tyler P. Green, Joseph P. Talley, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

The glomerular filtration barrier poses a significant challenge for circulating proteins, with molecules below ~60–70 kDa facing rapid renal clearance. Endogenous proteins have evolved sophisticated evasion mechanisms including oligomerization, carrier binding, electrostatic repulsion, and FcRn-mediated recycling. Understanding these natural strategies provides blueprints for engineering therapeutic proteins with improved pharmacokinetics. This review examines how endogenous proteins resist filtration, evaluates their application in protein engineering, and discusses clinical translation including established technologies (PEGylation, Fc-fusion) and emerging strategies (albumin-binding domains, glycoengineering). We address critical challenges of balancing half-life extension with tissue penetration, biological activity, and immunogenicity—essential considerations for the rational design of next-generation …


Preferences Of Health Professions Learners: A Scoping Review Of The Use And Role Of Dces In Health Professions Education, Sarah O'Neal, Natalie Smith, Jan Ostermann Ph.D., Binbin Zheng, Laiton Steele, Chris Gillette Jan 2026

Preferences Of Health Professions Learners: A Scoping Review Of The Use And Role Of Dces In Health Professions Education, Sarah O'Neal, Natalie Smith, Jan Ostermann Ph.D., Binbin Zheng, Laiton Steele, Chris Gillette

Faculty Publications

While discrete choice experiments (DCE), have increasingly been used in the medical literature, little is known about the use of these methods for eliciting preferences from and about students and trainees in health professions. The objectives of this scoping review are to (1) describe the extent to which DCEs have been used in health professions’ education, (2) identify which health professionals have been studied, and (3) identify thematic areas of research in which these methods have been used thematic areas. Between June and September 2024, we conducted a scoping review of the PubMed/Medline, EconLit, Web of Science, and Global Index …


Sociodemographic And Hiv-Related Characteristics Associated With Mental Health Diagnoses Among People Living With Hiv, Monique J. Brown Ph.D., Mph, Jiayang Xiao, Xueying Yang Ph.D., Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D. Jan 2026

Sociodemographic And Hiv-Related Characteristics Associated With Mental Health Diagnoses Among People Living With Hiv, Monique J. Brown Ph.D., Mph, Jiayang Xiao, Xueying Yang Ph.D., Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Mental health diagnoses have been linked to poor HIV treatment outcomes and poorer quality of life among people living with HIV (PLWH). Therefore, this study aimed to investigate the association between sociodemographic and HIV-related characteristics, and common and serious mental health disorders among PLWH in South Carolina (SC). Data were obtained from the integrated system of statewide electronic health record (EHR) data in SC (2006–2019; N = 8,124). Multivariable logistic regression models were used to determine the associations between sociodemographic and HIV-related characteristics, and common mental health disorders and serious mental health disorders. Among the study population, 4% were 60 …


The Nutritional Environment And Food Access Of Female Athletes At Hbcus: A Qualitative Analysis, Nancy A. Uriegas, Zachary K. Winkelmann Ph.D., Lat, Atc, Chse, Dawn M. Emerson, Toni Torres-Mcgehee Ph.D., Lat, Atc, Facsm Jan 2026

The Nutritional Environment And Food Access Of Female Athletes At Hbcus: A Qualitative Analysis, Nancy A. Uriegas, Zachary K. Winkelmann Ph.D., Lat, Atc, Chse, Dawn M. Emerson, Toni Torres-Mcgehee Ph.D., Lat, Atc, Facsm

Faculty Publications

Purpose:

Female student-athletes attending Historically Black Colleges and Universities (HBCUs) may encounter distinct challenges related to food access, particularly when their campuses are situated in areas with limited food availability. This study assessed food security (FS) and explored the lived experiences of HBCU female student-athletes regarding their food environments and access to nutrition.

Methods:

This qualitative study used a semi-structured interview protocol derived from quantitative data. Participants were 10 HBCU female athletes (age = 19 ± 1 years) living in on-campus dormitories; recruited after completing a quantitative study examining energy needs. The three-part semi-structured interview protocol included questions about personal …