Digital Commons Network^™

Entrepreneurs On Horseback: Reflections On The Organization Of Law, Darian M. Ibrahim, D. Gordon Smith

Faculty Publications

“Law and entrepreneurship” is an emerging field of study. Skeptics might wonder whether law and entrepreneurship is a variant of that old canard, the Law of the Horse. In this Essay, we defend law and entrepreneurship against that charge and urge legal scholars to become even more engaged in the wide-ranging scholarly discourse regarding entrepreneurship. In making our case, we argue that research at the intersection of entrepreneurship and law is distinctive. In some instances, legal rules and practices are tailored to the entrepreneurial context, and in other instances, general rules of law find novel expression in the entrepreneurial context. …

An Informational Approach To The Mass Imprisonment Problem, Adam M. Gershowitz

Faculty Publications

The United States is plagued by the problem of mass imprisonment, with its prison population having risen by 500% in the last three decades. Because the overwhelming majority of criminal cases are resolved through plea bargaining, there is room for prosecutors to reduce mass imprisonment by exercising their wide discretion. At present, prosecutors likely do not give much consideration to the overcrowding of America 's jails and prisons when making their plea bargain offers. However, if prosecutors were regularly advised of such overcrowding they might offer marginally lower sentences across the board. For instance, a prosecutor who typically offers a …

Jacobus Tenbroek, Participatory Justice, And The Un Convention On The Rights Of Persons With Disabilities, Michael Ashley Stein, Janet E. Lord

Faculty Publications

No abstract provided.

Hothouse Flowers: The Vices And Virtues Of Climate Federalism, Jonathan H. Adler

Faculty Publications

Although economic theory would predict that states would lag behind federal efforts to control environmentally harmful emissions, there has been far more action on climate change in state capitols than in Washington, D.C. Without federal action, states have stepped in to fill the policy void on climate change. State-level action on climate change is unlikely, in itself, to have much impact on atmospheric concentrations of greenhouse gases or projected rates of future warming. Nonetheless, the level of state activity is significant.

The aggressiveness of state climate policy initiatives, and potential conflict between federal and state regulatory measures, provides an opportunity …

Theology And Disestablishment In Colonial America: Insights From A Quaker, A Puritan, And A Baptist, Nicholas Miller

Faculty Publications

No abstract provided.

Resuscitating Hospital Enterprise Liability, Philip G. Peters Jr.

Faculty Publications

No tort reform has more potential to improve the quality of medical care and to reduce the frequency of patient injuries than exclusive hospital enterprise liability. Hospital enterprise liability would make hospitals liable for all patient injuries occurring in the hospital that are the product of provider negligence, regardless of the independent contractor status of the providers. In its "exclusive" form, enterprise liability would also eliminate the personal liability of individual physicians and nurses. Exclusive hospital enterprise liability has the potential to revive the dormant deterrent power of tort law. The reasons are simple. Unlike individual physicians, hospitals are experience-rated …

Peripheral Intravenous Catheters Started In Prehospital And Emergency Department Settings, Ligia Zarate, Barbara Mandleco, Russell Wilshaw, Patricia K. Ravert

Faculty Publications

The purpose of this study was to determine the rates of phlebitis in trauma patients according to where the peripheral intravenous catheter (PIVC) was inserted in a prehospital setting or in an emergency department setting. Variables investigated also included where the catheter was anatomically placed, the gauge of the catheter, and the patients' Injury Severity Score. The overall phlebitis rate was 5.79%. The rate of phlebitis was 2.92% when started by an RN in the emergency department, 6.09% when started by an intermediate emergency medical technician and 7.78% when started by a paramedic in prehospital setting. There was no significant …

Skill Evaluation In Women's Volleyball, Lindsay W. Florence, Gilbert W. Fellingham, Pat R. Vehrs, Nina P. Mortensen

Faculty Publications

The Brigham Young University Women's Volleyball Team recorded and rated all skills (pass, set, attack, etc.) and recorded rally outcomes (point for BYU, rally continues, point for opponent) for the entire 2006 home volleyball season. Only sequences of events occurring on BYU's side of the net were considered. Events followed one of these general patterns: serve-outcome, pass-set-attack-outcome, or block-dig-set-attack-outcome. These sequences of events were assumed to be first-order Markov chains where the quality of each contact depended only on the quality of the previous contact but not explicitly on contacts further removed in the sequence. We represented these sequences in …

Excess 210Pb Inventories And Fluxes Along The Continental Slope And Basins Of The Gulf Of Papua, Zahid Muhammad, Samuel J. Bentley, Lawrence A. Febo, André W. Droxler, Gerald R. Dickens, Larry C. Peterson, Bradley N. Opdyke

Faculty Publications

Sediment samples were collected from continental slopes and marginal basins in the Gulf of Papua and analyzed for excess 210Pb to elucidate transport processes of fine-grained particles to this region. Estimated excess 210Pb fluxes of 1.0-12.8 dpm cm-2 a-1 were derived from measured seabed inventories. Highest sediment accumulation rates (0.28-0.35 cm a-) were measured along the northeastern shelf edge, and they decrease in seaward directions and along isobaths to the southwest. The excess 210Pb flux could result from either focused deposition of high-210Pb activity sediments from the continental shelf and upper slope or scavenging of 210Pb brought landward from deep-sea …

Monte Carlo Calculations And Measurements Of Absorbed Dose Per Monitor Unit For The Treatment Of Uveal Melanoma With Proton Therapy, Nicholas Koch, Wayne D. Newhauser, Uwe Titt, Dan Gombos, Kevin Coombes, George Starkschall

Faculty Publications

The treatment of uveal melanoma with proton radiotherapy has provided excellent clinical outcomes. However, contemporary treatment planning systems use simplistic dose algorithms that limit the accuracy of relative dose distributions. Further, absolute predictions of absorbed dose per monitor unit are not yet available in these systems. The purpose of this study was to determine if Monte Carlo methods could predict dose per monitor unit (D/MU) value at the center of a proton spread-out Bragg peak (SOBP) to within 1% on measured values for a variety of treatment fields relevant to ocular proton therapy. The MCNPX Monte Carlo transport code, in …

Gene Rearrangement Analysis And Ancestral Order Inference From Chloroplast Genomes With Inverted Repeat, Feng Yue, Liying Cui, Claude W. Depamphilis, Bernard M.E. Moret, Jijun Tang

Faculty Publications

Background
Genome evolution is shaped not only by nucleotide substitutions, but also by structural changes including gene and genome duplications, insertions, deletions and gene order rearrangements. The most popular methods for reconstructing phylogeny from genome rearrangements include GRAPPA and MGR. However these methods are limited to cases where equal gene content or few deletions can be assumed. Since conserved duplicated regions are present in many chloroplast genomes, the inference of inverted repeats is needed in chloroplast phylogeny analysis and ancestral genome reconstruction.

Results
We extend GRAPPA and develop a new method GRAPPA-IR to handle chloroplast genomes. A test of GRAPPA-IR …

Synthesis And In Vitro Properties Of Trimethylamine- And Phosphonate-Substituted Carboranylporphyrins For Application In Bnct, Michael W. Easson, Frank R. Fronczek, Timothy J. Jensen, M. Graça H. Vicente

Faculty Publications

A series of carboranylporphyrins containing either amine or phosphonic acid functionalities and two to six closo-carborane clusters have been synthesized via a [2 + 2] condensation of a dimethylamino- or diethylphosphonate-substituted dipyrromethane with a dicarboranylmethyl-benzaldehyde. The X-ray structures of four key reaction intermediates (1, 2, 3, and 4a) and of two target porphyrins, the diphosphonate ester- and the diamino-tetracarboranylporphyrins 5b and 6a, are presented and discussed. In vitro studies using human carcinoma HEp2 and human glioblastoma T98G cells show that these porphyrins are non-toxic in the dark up to 100 μM concentrations, and that a tetracarboranylporphyrin bearing two quaternary ammonium …

Molecular Dynamics Simulations Of Biotin Carboxylase, Sten O.Nilsson Lili, Jiali Gao, Grover L. Waldrop

Faculty Publications

Biotin carboxylase catalyzes the ATP-dependent carboxylation of biotin and is one component of the multienzyme complex acetyl-CoA carboxylase that catalyzes the first committed step in fatty acid synthesis in all organisms. Biotin carboxylase from Escherichia coli, whose crystal structures with and without ATP bound have been determined, has served as a model system for this component of the acetyl-CoA carboxylase complex. The two crystal structures revealed a large conformational change of one domain relative to the other domains when ATP is bound. Unfortunately, the crystal structure with ATP bound was obtained with an inactive site-directed mutant of the enzyme. As …

The Innate Immune Database (Iidb), Martin Korb, G. R. Aistair, Vesteinn Thorsson, Christophe Battail, Bin Li, Daehee Hwang, Kathleen A. Kennedy, Jared C. Roach, Carrie M. Rosenberger, Mark Gilchrist, Daniel Zak, Carrie Johnson, Bruz Marzolf, Alan Aderem, Ilya Shmulevich, Hamid Bolouri

Faculty Publications

Background: As part of a National Institute of Allergy and Infectious Diseases funded collaborative project, we have performed over 150 microarray experiments measuring the response of C57/BL6 mouse bone marrow macrophages to toll-like receptor stimuli. These microarray expression profiles are available freely from our project web site http://www.innateImmunity-systemsbiology.org. Here, we report the development of a database of computationally predicted transcription factor binding sites and related genomic features for a set of over 2000 murine immune genes of interest. Our database, which includes microarray co-expression clusters and a host of web-based query, analysis and visualization facilities, is available freely via the …

Family Therapy And Childhood-Onset Schizophrenia: Pursuing Clinical And Bio/Psycho/Social Competence, Stanley D. Hall, Roy A. Bean

Faculty Publications

Childhood-onset schizophrenia is perceived as more complicated because of its complexity, pervasive duration, and impact on individual and family functioning. Viewing the symptoms of childhood schizophrenia as creating a bio/psycho/social competence within which the therapist and family must interact may help contribute to treatment success. Competent family therapists working within this culture should be knowledgeable about the characteristics of childhood-onset schizophrenia, aware of their own biases towards psychosis, and skillful in its treatment. Guidelines are provided to help therapists identify their attitudes about schizophrenia and understand appropriate skills for treating the disorder.

Double-Stranded Rna-Activated Protein Kinase Pkr Of Fishes And Amphibians: Varying The Number Of Double-Stranded Rna Binding Domains And Lineage-Specific Duplications, Loubna Tazi, Stefan Rothenburg, Nikolaus Deigendesch, Madhusudan Dey, Thomas E. Dever

Faculty Publications

Double-stranded (ds) RNA, generated during viral infection, binds and activates the mammalian anti-viral protein kinase PKR, which phosphorylates the translation initiation factor eIF2alpha leading to the general inhibition of protein synthesis. Although PKR-like activity has been described in fish cells, the responsible enzymes eluded molecular characterization until the recent discovery of goldfish and zebrafish PKZ, which contain Z-DNA-binding domains instead of dsRNA-binding domains (dsRBDs). Fish and amphibian PKR genes have not been described so far. Results- Here we report the cloning and identification of 13 PKR genes from 8 teleost fish and amphibian species, including zebrafish, demonstrating the coexistence of …

Human Resources Challenges And Opportunities In China: A Case From The Hospitality Industry, Ilan Alon, Tatiana Ferreira

Faculty Publications

The purpose of this study is to underline some of the distinctive practices of the hospitality industry in China. Particularly, we have interviewed several industry experts in luxury hotel properties in China and the USA and have compared their human resources practices. We found that luxury hotels which want to achieve international levels of service must invest more time in hiring and training their Chinese employees. Chinese employees are hired based on personality, and are found to be lacking a service mentality. Cultural and institutional differences in human resources account for the differences that exist between Chinese employees in the …

Hostility & Ambulatory Blood Pressure, Elizabeth J. Vella, Thomas W. Karmarck, Saul Shiffman

Faculty Publications

This study sought to determine the role of hostility in moderating the effects of positive social interactions on ambulatory blood pressure (ABP). Design: Participants (341 adults) completed the Cook-Medley Hostility Scale and underwent ABP monitoring, assessed every 45 min during waking hours across 6 days. An electronic diary measuring mood and social interactions was completed at each ABP assessment. Main Outcome Measures: The dependent variables from the ABP monitor included systolic blood pressure, diastolic blood pressure, and heart rate.

Promoting Self-Confidence In Clinical Nursing Students, Karen M. Lundberg

Faculty Publications

Clinical nursing instructors are continually telling their students that they just need more confidence. But how do students find this needed confidence and how can nursing instructors help them? The author discusses sources and principles of confidence in relationship to teaching behaviors and strategies for increasing self-confidence, such as simulations, peer modeling, story telling, skill review sessions, and journaling.

Promoting Physical Activity In Middle School Girls: Trial Of Activity For Adolescent Girls, Larry S. Webber, Diane J. Catellier, Leslie A. Lytle, David M. Murray, Charlotte A. Pratt, Deborah Rohm Young, John P. Elder, Timothy G. Lohman, June Stevens, Jared B. Jobe, Russell R. Pate

Faculty Publications

Background - Physical activity is important for weight control and good health; however, activity levels decline in the adolescent years, particularly in girls.

Design - Group randomized controlled trial.

Setting/participants - Middle school girls with English-speaking skills and no conditions to prevent participation in physical activity in 36 schools in six geographically diverse areas of the United States. Random, cross-sectional samples were drawn within schools: 6th graders in 2003 (n=1721) and 8th graders in 2005 (n=3504) and 2006 (n=3502).

Intervention - A 2-year study-directed intervention (fall 2003 to spring 2005) targeted schools, community agencies, …

Determination Of Enantiomeric Compositions Of Analytes Using Novel Fluorescent Chiral Molecular Micelles And Steady State Fluorescence Measurements, Alicia A. Williams, Sayo O. Fakayode, Onur Alptürk, Christina M. Jones, Mark Lowry, Robert M. Strongin, Isiah M. Warner

Faculty Publications

Novel fluorescent chiral molecular micelles (FCMMs) were synthesized, characterized, and employed as chiral selectors for enantiomeric recognition of non-fluorescent chiral molecules using steady state fluorescence spectroscopy. The sensitivity of the fluorescence technique allowed for investigation of low concentrations of chiral selector (3.0∈×∈10 -5 M) and analyte (5.0∈×∈10 -6 M) to be used in these studies. The chiral interactions of glucose, tartaric acid, and serine in the presence of FCMMs poly(sodium N-undecanoyl-l-tryptophanate) [poly-l-SUW], poly(sodium N-undecanoyl-l-tyrosinate) [poly-l-SUY], and poly(sodium N-undecanoyl-l- phenylalininate) [poly-SUF] were based on diastereomeric complex formation. Poly-l-SUW had a significant fluorescence emission spectral difference as compared to poly-l-SUY and poly-l-SUF …

The Human Intermediate Filament Database: Comprehensive Information On A Gene Family Involved In Many Human Diseases, Ildiko Szeverenyi, Andrew J. Cassidy, Wang Chung Cheuk, Bernett T.K. Lee, John E.A. Common, Stephen C. Ogg, Huijia Chen, Yin Sim Shu, Walter L.P. Goh, Woei Ng Kee, John A. Simpson, Lian Chee Li, Hui Eng Goi, Bin Li, Declan P. Lunny, Danny Chuon, Aparna Venkatesh, Hoe Khoo Kian, W. H.Irwin Mclean, Ping Lim Yun, E. Birgitte Lane

Faculty Publications

We describe a revised and expanded database on human intermediate filament proteins, a major component of the eukaryotic cytoskeleton. The family of 70 intermediate filament genes (including those encoding keratins, desmins, and lamins) is now known to be associated with a wide range of diverse diseases, at least 72 distinct human pathologies, including skin blistering, muscular dystrophy, cardiomyopathy, premature aging syndromes, neurodegenerative disorders, and cataract. To date, the database catalogs 1,274 manually-curated pathogenic sequence variants and 170 allelic variants in intermediate filament genes from over 459 peer-reviewed research articles. Unrelated cases were collected from all of the six sequence homology …

Accumulating Disadvantage Over The Life Course: Evidence From A Longitudinal Study Investigating The Relationship Between Educational Advantage In Youth And Health In Middle Age, Katrina M. Walsemann, Arline T. Geronimus, Gilbert C. Gee

Faculty Publications

Recent studies suggest the importance of examining cumulative risk or advantage as potential predictors of health over the life course. Researchers investigating the cumulative health effects of education, however, have mainly conceptualized education in years or degrees, often disregarding educational quality and access to educational opportunities that may place individuals on divergent academic trajectories. We investigate whether educational advantages in youth are associated with an individual's health trajectory. We develop a novel index of educational advantage and employ random-intercept modeling using data from the National Longitudinal Survey of Youth. We find a widening health disparity in adulthood between respondents with …

Enhanced Lipid Stability In Whole Wheat Flour By Lipase Inactivation And Antioxidant Retention, Devin J. Rose, Lynn V. Ogden, Michael L. Dunn, Oscar A. Pike

Faculty Publications

The purpose of this study was to determine the effectiveness of dry heat, steam, and microwave treatments in decreasing lipase activity, while retaining antioxidant activity, to stabilize whole wheat flour against lipid degradation during storage. Bran was heat-treated in 230-g batches using four levels (exposure times) for each of the three treatment methods. Lipase activity and antioxidant activity were quantified for all treatment combinations. None of the treatments significantly decreased antioxidant activity; the levels determined to be optimal, inasmuch as further heating did not significantly decrease lipase activity, were 25 min of dry heat, 60 sec of microwave (1000W), and …

School-Based Mentoring: An Effective Intervention With Students At Risk For Ebd, Paul Caldarella, Shauna Valentine, K. Richard Young, Michael Adams

Faculty Publications

EBD Students experience fewer positive outcomes, more frequent removal from class, and less academic instruction than any other group of students with disabilities; Years of academic failure and peer rejection before evaluations and diagnoses are begun. (Lane, Gresham, & O’Shaugnessy, 2002;Jolivette, Stitchter, Nelson, Scott, & Liaupsin, 2000)

The Importance Of Generalizability To Anomaly Detection, Gilbert L. Peterson, Brent T. Mcbride

Faculty Publications

In security-related areas there is concern over novel “zero-day” attacks that penetrate system defenses and wreak havoc. The best methods for countering these threats are recognizing “nonself” as in an Artificial Immune System or recognizing “self” through clustering. For either case, the concern remains that something that appears similar to self could be missed. Given this situation, one could incorrectly assume that a preference for a tighter fit to self over generalizability is important for false positive reduction in this type of learning problem. This article confirms that in anomaly detection as in other forms of classification a tight fit, …

Systems Biology Approaches Identify Atf3 As A Negative Regulator Of Toll-Like Receptor 4 (Nature (2006) 441, (173-178)), Mark Gilchrist, Vesteinn Thorsson, Bin Li, Alistair G. Rust, Martin Korb, Jared C. Roach, Kathleen Kennedy, Tsonwin Hai, Hamid Bolouri, Alan Aderem

Faculty Publications

No abstract provided.

Below- And Aboveground Biomass Of Spartina Alterniflora: Response To Nutrient Addition In A Louisiana Salt Marsh, Faith A. Darby, R. Eugene Turner

Faculty Publications

The responses of Spartina alterniflora above- and belowground biomass to various combinations of N, P, and Fe were documented in a 1-year field experiment in a Louisiana salt marsh. Five levels of N additions to 0.25 m2 plots resulted in 18% to 138% more live aboveground biomass compared to the control plots and higher stem densities, but had no effect on the amount of live belowground biomass (roots and rhizomes; R&R). There was no change in the aboveground biomass when P or Fe was added as part of a factorial experiment of +P, +N, and +Fe additions, but there was …

Imprinting Of An Evolutionarily Conserved Antisense Transcript Gene Apeg3, Jung Ha Choo, Jeong Do Kim, Joomyeong Kim

Faculty Publications

APeg3 is an antisense transcript gene of Peg3, which has been recently identified from rat brain. Careful analyses of EST databases indicated that a homologous transcript also exists in other mammalian species, including mouse, cow and human. 5′-and 3′-RACE experiments have subsequently identified a 900-bp cDNA sequence of APeg3 from mouse brain. Mouse APeg3 is localized in the 3′UTR of Peg3 with an intronless genomic structure. The expression of mouse APeg3 is derived mainly from the paternal allele, indicating the imprinting of this antisense transcript gene in brain. Strand-specific RNA analyses also revealed the expression of both human and cow …

Origin Of The Eastern Brownsnake, Pseudonaja Textilis (Duméril, Bibron And Duméril) (Serpentes: Elapidae: Hydrophiinae) In New Guinea: Evidence Of Multiple Dispersals From Australia, And Comments On The Status Of Pseudonaja Textilis Pughi Hoser 2003, David J. Williams, Mark O'Shea, Roland L. Daguerre, Catharine E. Pook, Wolfgang Wüster, Christopher J. Hayden, John D. Mcvay, Owen Paiva, Teatu Lohi Matainaho, Kenneth D. Winkel, Christopher C. Austin

Faculty Publications

Pseudonaja textilis is a widespread and common snake in eastern parts of Australia, but its distribution in New Guinea is poorly understood, and the origin of the New Guinea populations and its timing have been the subject of much speculation. Phylogenetic analysis of mitochondrial DNA sequences from three New Guinea populations of P. textilis indicates that New Guinea was colonised from two independent eastern and western migration routes most likely in the Pleistocene. One dispersal event from northern Queensland led to the populations in eastern New Guinea (Milne Bay, Oro and Central Provinces, Papua New Guinea), whereas another, from Arnhem …