Digital Commons Network^™

Seminaphthofluorones Are A Family Of Water-Soluble, Low Molecular Weight, Nir-Emitting Fluorophores, Youjun Yang, Mark Lowry, Xiangyang Xu, Jorge O. Escobedo, Martha Sibrian-Vazquez, Lisa Wong, Corin M. Schowalter, Timothy J. Jensen, Frank R. Fronczek, Isiah M. Warner, Robert M. Strongin

Faculty Publications

A readily accessible new class of near infrared (NIR) molecular probes has been synthesized and evaluated. Specific fluorophores in this unique xanthene based regioisomeric seminaphthofluorone dye series exhibit a combination of desirable characteristics including (i) low molecular weight (339 amu), (ii) aqueous solubility, and (iii) dual excitation and emission from their fluorescent neutral and anionic forms. Importantly, systematic changes in the regiochemistry of benzannulation and the ionizable moieties afford (iv) tunable deep-red to NIR emission from anionic species and (v) enhanced Stokes shifts. Anionic SNAFR-6, exhibiting an unusually large Stokes shift of ≈200 nm (5,014 cm-1) in aqueous buffer, embodies …

Neighborhood Characteristics And Hypertension, Mahasin S. Mujahid, V. Diez Roux, Jeffrey D. Morenoff, Trivellore E. Raghunathan, Richard S. Cooper, Hanyu Ni, Steven Shea

Faculty Publications

The goal of this study was to investigate cross-sectional associations between features of neighborhoods and hypertension and to examine the sensitivity of results to various methods of estimating neighborhood conditions. Methods: We used data from the Multi-Ethnic Study of Atherosclerosis on 2612 individuals 45-85 years of age. Hypertension was defined as systolic blood pressure above 140 mm Hg, diastolic pressure above 90 mm Hg, or use of antihypertensive medications. Neighborhood (census tract) conditions potentially related to hypertension (walking environment, availability of healthy foods, safety, social cohesion) were measured using information from a separate phone survey conducted in the study neighborhoods. …

Temperature Sensitivity And Cell Division Defects In An Escherichia Coli Strain With Mutations In Yghb And Yqja, Encoding Related And Conserved Inner Membrane Proteins, Kandi Thompkins, Ballari Chattopadhyay, Ying Xiao, Margaret C. Henk, William T. Doerrler

Faculty Publications

Ludox density gradients were used to enrich for Escherichia coli mutants with conditional growth defects and alterations in membrane composition. A temperature-sensitive mutant named Lud135 was isolated with mutations in two related, nonessential genes: yghB and yqjA. yghB harbors a single missense mutation (G203D) and yqjA contains a nonsense mutation (W92TGA) in Lud135. Both mutations are required for the temperature-sensitive phenotype: targeted deletion of both genes in a wild-type background results in a strain with a similar phenotype and expression of either gene from a plasmid restores growth at elevated temperatures. The mutant has altered membrane phospholipid levels, with elevated …

Engendering Genocide: The Akayesu Case Before The International Criminal Tribunal For Rwanda, Beth Van Schaack

Faculty Publications

This article - which will appear as a chapter in a "law stories" volume on Human Rights Advocacy - discusses the role that advocacy by women's rights and human rights organizations and activists played in gaining legal recognition of the concept of genocidal rape within international criminal law. The chapter discusses the procedural history and jurisprudential contributions of the case against Jean Paul Akayesu before the International Criminal Tribunal for Rwanda. The chapter then traces Akayesu's legacy with respect to gender justice with respect to subsequent cases before the ad hoc international tribunals and within the Statute of the international …

Book Review: Nanoethics: The Ethical And Social Implications Of Nanotechnology, Kevin Elliott

Faculty Publications

No abstract provided.

The Uncertain Future Of School Desegregation And The Importance Of Goodwill, Good Sense, And A Misguided Decision, Derek W. Black

Faculty Publications

The article was part of a symposium on the jurisprudence of Supreme Court Justice Sandra Day O’Connor. First, the article analyzed whether the Court’s decision in Parents Involved v. Seattle Schools was consistent with Justice O’Connor’s majority opinion in Grutter v. Bollinger. The article concludes that Parents Involved narrowly construed the holding in Grutter and limited its effect. Second, the article assessed the practical import of the decision in Parents Involved. It found that the opinion made voluntary desegregation more difficult than it otherwise would be and, thus, would discourage many school districts from taking progressive action. Unfortunately, the article …

Association Between Muscular Strength And Mortality In Men: Prospective Cohort Study, Jonatan R. Ruiz, Xuemei Sui, Felipe Lobelo, James R. Morrow Jr., Allen W. Jackson, Michael Sjöström, Steven N. Blair

Faculty Publications

Objective: To examine prospectively the association between muscular strength and mortality from all causes, cardiovascular disease, and cancer in men.

Design: Prospective cohort study.

Setting: Aerobics center longitudinal study.

Participants: 8762 men aged 20-80.

Main outcome measures: All cause mortality up to 31 December 2003; muscular strength, quantified by combining one repetition maximal measures for leg and bench presses and further categorised as age specific thirds of the combined strength variable; and cardiorespiratory fitness assessed by a maximal exercise test on a treadmill.

Results: During an average follow-up of 18.9 years, 503 deaths occurred (145 cardiovascular disease, 199 cancer). Age …

Administrative Judges' Role In Developing Social Policy, Charles H. Koch Jr.

Faculty Publications

No abstract provided.

Doing More Or Doing Less For The Environment: Shedding Light On Epa's "Stealth" Method Of Environmental Enforcement, Ronald H. Rosenberg

Faculty Publications

Since the 1970s, environmental protection goals have gone from general statements of political desire to highly articulated systems of environmental regulation implemented by federal, state, and local governments. Environmental statutes have been enacted giving administrative agencies such as the U.S. Environmental Protection Agency (EPA) the responsibility for translating broad policy goals into specific regulatory requirements. Through its enforcement program, EPA seeks to assure that these general goals are achieved by individual actors. This Article examines a recent trend in EPA's practices, increased reliance on internal agency methods of enforcement. The study analyzes EPA's administrative enforcement system with particular emphasis on …

Book Review Of The Best Interests Of The Child In Healthcare, James G. Dwyer

Faculty Publications

No abstract provided.

It's What We're Here For: Nurses Caring For Military Personnel During The Persian Gulf Wars, Patricia Rushton, Lynn Clark Callister, Jared E. Scott

Faculty Publications

Military nursing service during wartime represents significant contributions to a unique type of health care. The purposes of this study were to: (1) generate themes that elucidate combat nursing experiences, (2) honor nurses who served by sharing their stories, and (3) permanently archive accounts of nursing personnel who served during the Persian Gulf Wars during the late 20th and early 21st centuries. Eleven military nurses who provided health care to American troops in the Persian Gulf participated in a historical study as part of the ongoing Nurses at War oral history project documenting the experiences of nurses during times of …

Controlling Methamphetamine Precursors: The View From The Trenches, Curtis J. Vanderwaal Dr., Rachel M. Bishop, Duane C. Mcbride, Kimberly Rosales, Jamie F. Chriqui, Jean C. O'Connor, Yvonne M. Terry-Mcelrath

Faculty Publications

This paper reports on key informant (KI) and focus group interviews exploring the relationships between methamphetamine small toxic lab (STL) seizures and related activity, and methamphetamine precursor laws. The primary purposes of the KI and focus group interviews were to: 1) examine KIs’ perceptions of the impact of their state’s precursor laws; 2) explore KIs’ perceptions of the organizational and procedural facilitators and barriers to successful implementation of the law(s); and 3) evaluate KIs’ perceptions of the relative importance of various precursor law provisions. Research questions included: 1) What were KIs’ perceptions of the impact of their state’s precursor laws?; …

College Males: Keeping Them Engaged On Your Campus, Jason A. Laker

Faculty Publications

There has been much discussion in the popular media over the last few years to the effect that there is a “crisis” with regard to men in higher education. There have been several angles in these reports, including arguments suggesting that men are declining in student ranks, or that women are outpacing their male counterparts. In any case, these reports have asked questions about where the men are if not in college; and what will be the consequences of this problem in terms of the workforce, families, or the potential nature and future of higher education. One could easily be …

School Librarianship: Career Choice And Recruitment, Donna M. Shannon

Faculty Publications

No abstract provided.

Understanding (Dis)Abilities Through Children's Literature, Stephanie A. Kurtts, Karen W. Gavigan

Faculty Publications

The authors of this article examined how pre-service teachers can use children's and young adult literature about disabilities to enhance understanding of individual differences through a bibliotherapeutic approach. An introduction to bibliotherapy is provided along with related literature from the field. Strategies for using children's and young adult literature to enhance the understanding of issues associated with disabilities are presented along with one teacher candidate's application of the literature in her classroom. The authors have also included a selected bibliography of children's literature on disabilities as well as relevant websites

Open And Accessible: The Relationship Between Closures And Circulation In School Library Media Centers., Gail Dickinson, E Cogdell, Karen W. Gavigan

Faculty Publications

No abstract provided.

Effect Of Iron Source On Color And Appearance Of Micronutrient-Fortified Corn Flour Tortillas, A. T. Richins, K. E. Burton, Heather F. Pahulu, Laura K. Jefferies, Michael L. Dunn

Faculty Publications

Iron deficiency anemia is a widespread occurrence. Consequently, iron is commonly added in cereal fortification programs. However, many iron sources cause undesirable sensory changes, especially color changes, in the food being fortified. This study evaluated the effect of different iron sources on CIE L*a*b* color values and sensory color perception in fortified corn tortillas. Corn masa flour was fortified with micronutrient premix containing vitamins, zinc, and one of eight iron compounds. Iron sources included ferrous fumarate (F), ferrous sulfate (S), ferric orthophosphate (OP), ferrous lactate (L), ferrous gluconate (G), ferric pyrophosphate (PP), sodium iron (III)-EDTA, and A-131 electrolytic iron (E), …

Manipulating The Cavity Of A Porous Material Changes The Photoreactivity Of Included Guests, Mahender B. Dewal, Yuewen Xu, Jun Yang, Fiaz Mohammed, Mark D. Smith, Linda S. Shimizu

Faculty Publications

Changing an ether to a ketone within the framework of a bis-urea macrocycle has little effect on the supramolecular assembly of this building block into porous crystals but introduces a triplet sensitizer into the framework that dramatically alters the photochemical reactions of included guests.

The Role Of Upstream Sequences In Selecting The Reading Frame On Tmrna, Allen R. Buskirk, Mickey R. Miller, David W. Healey, Jonathan D. Dewey, Stephen G. Robison

Faculty Publications

tmRNA acts first as a tRNA and then as an mRNA to rescue stalled ribosomes in eubacteria. Two unanswered questions about tmRNA function remain: how does tmRNA, lacking an anticodon, bypass the decoding machinery and enter the ribosome? Secondly, how does the ribosome choose the proper codon to resume translation on tmRNA? According to the -1 triplet hypothesis, the answer to both questions lies in the unique properties of the three nucleotides upstream of the first tmRNA codon. These nucleotides assume an A-form conformation that mimics the codon-anticodon interaction, leading to recognition by the decoding center and choice of the …

Emergency Nurses’ Perceptions Of Size, Frequency, And Magnitude Of Obstacles And Supportive Behaviors In End-Of-Life Care, Renea L. Beckstrand, Michelle D. Smith, Sondra Heaston, A. Elaine Bond

Faculty Publications

Introduction: Emergency nurses care for dying patients daily. The process of dying in an emergency department can be complicated. Research on specific obstacles that impede the delivery of end-of-life care in emergency departments and behaviors that support it is limited.

Methods: A 70-item questionnaire was mailed to randomly selected ENA members. Subjects were asked to rate items on the size, frequency, and manitude of obstacles and supportive behaviors that relate to end-of-life care for ED patients.

Results:

The perceived obstacles with the greatest magnitude were as follows: (a) ED nurses’ work loads being too high to allow adequate time for …

Heart Rate Variability Characteristics In Sedentary Postmenopausal Women Following Six Months Of Exercise Training: The Drew Study, Conrad P. Earnest, Carl J. Lavie, Steven N. Blair, Timothy S. Church

Faculty Publications

Background: Decreased heart rate variability (HRV) is associated with a higher risk of mortality. Overall, postmenopausal women have lower levels of HRV than premenopausal women, which may be additionally complicated by lifestyle related behaviors such as physical inactivity and obesity. Though cardiorespiratory exercise training increases HRV, little is known regarding the exercise dose necessary to promote improvement.

Methodology/Principle Findings: Our primary aim was to measure HRV in post-menopausal women following 6-moths of exercise training. We examined supine resting HRV in 373 post-menopausal women (45-75 y) after 6-months of randomly assigned and double-blinded administered exercise training exercise training at 50%, 100% …

Identification Of Rickettsia Felis In The Salivary Glands Of Cat Fleas, Kevin R. Macaluso, Walairat Pornwiroon, Vsevolod L. Popov, Lane D. Foil

Faculty Publications

Rickettsia felis, a flea-associated rickettsial pathogen, has been identified in many tissues, including the digestive and reproductive tissues, within the cat flea, Ctenocephalides felis. We utilized transmission electron microscopy and polymerase chain reaction to identify R. felis in the salivary glands of fed fleas and further define the distribution of R. felis within the arthropod host. We identified Rickettsia-like organisms in salivary glands using electron microscopy. Sequence analysis of portions of the Rickettsia genus-specific 17-kDa antigen gene and R. felis plasmid confirmed the morphological identification of R. felis in cat flea salivary glands. This is the first report of R. …

Preparation Of Botanical Samples For Biomedical Research, Zhijun Liu

Faculty Publications

Plants are chemical storehouses, a fact which has driven countless multidisciplinary quests for bioactive compounds. As the very first step of botanical research, the whole desire is to find "hit" plants with specific bioactivities. It is logical to use some strategies that can maximize the chances of finding these "hits" with limited time and resources. In addition to selecting the right plants for screening, how the plant extracts are prepared can also influence the bioactivity screening outcomes. An extract from the same plant material can be quite different in chemical composition having different preparations. Because of the complex mixture nature …

The Development Of Day-Night Differences In Sleep And Wakefulness In Norway Rats And The Effect Of Bilateral Enucleation, Andrew J. Gall, William D. Todd, Baisali Ray, Cassandra M. Coleman, Mark S. Blumberg

Faculty Publications

The suprachiasmatic nucleus (SCN) exhibits circadian rhythmicity in fetal and infant rats, but little is known about the consequences of this rhythmicity for infant behavior. Here, in Experiment 1, we measured sleep and wakefulness in rats during the day and night in postnatal day (P)2, P8, P15 and P21 subjects. As early as P2, day-night differences in sleep-wake activity were detected. Nocturnal wakefulness began to emerge around P15 and was reliably expressed by P21. We hypothesized that the process of photic entrainment over the first postnatal week, which depends upon the development of connectivity between the retinohypothalamic tract (RHT) and …

Word Recognition Materials For Native Speakers Of Taiwan Mandarin, Shawn L. Nissen, Richard W. Harris, Alycia Dukes

Faculty Publications

Purpose: To select, digitally record, evaluate, and psychometrically equate word recognition materials that can be used to measure the speech perception abilities of native speakers of Taiwan Mandarin in quiet. Method: Frequently used bisyllabic words produced by male and female talkers of Taiwan Mandarin were digitally recorded and subsequently evaluated using 20 native listeners with normal hearing at 10 intensity levels (-5 to 40 dB HL) in increments of 5 dB. Results: Using logistic regression, 200 words with the steepest psychometric slopes were divided into 4 lists and 8 half-lists that were relatively equivalent in psychometric function slope. To increase …

The Application Of Rfra To Override Employment Nondiscrimination Clauses Embedded In Federal Social Services Programs, Carl H. Esbeck

Faculty Publications

General federal employment nondiscrimination legislation permits religious organizations to take religion into account when making employment decisions. However, some federal social service programs have embedded in their authorizing legislation a nondiscrimination clause binding on recipients of program grants. And a few of these embedded clauses require that grantees (including religious grantees) not discriminate in employment on the basis of religion. This extended essay demonstrates how the Religious Freedom Restoration Act of 1993 overrides these employment nondiscrimination clauses when applied to faith-based social service grantees. Not only is this the conclusion of the U.S. Department of Justice in its policy announced …

Long-Distance Interval Training Following Pre-Cooling With An Ice Vest, Ronald L. Hager, Iain Hunter, Gary W. Mack, Andrew R. Tegeder

Faculty Publications

This study evaluated how preparing for an interval workout, while wearing a cooling vest, affects core temperature (Tc), heart rate (HR), and interval time in long-distance runners. Nineteen male collegiate cross-country runners exercised under two different conditions: (a) wearing a Nike PreCool™ ice vest for one hour prior to the workout (30 minutes resting with the vest and 30 minutes while performing their warm-up); and (b) a control condition utilizing a traditional warm-up. Subjects performed 8 x 1000 m intervals. HR and Tc were measured prior to warm-up, immediately before the first interval, and after each interval. Tc measured before …

Acoustic Characteristics Of English Lexical Stress Produced By Native Mandarin Speakers, Shawn L. Nissen, Yanhong Zhang, Alexander L. Francis

Faculty Publications

Native speakers of Mandarin Chinese have difficulty producing native-like English stress contrasts. Acoustically, English lexical stress is multidimensional, involving manipulation of fundamental frequency (F0), duration, intensity and vowel quality. Errors in any or all of these correlates could interfere with perception of the stress contrast, but it is unknown which correlates are most problematic for Mandarin speakers. This study compares the use of these correlates in the production of lexical stress contrasts by 10 Mandarin and 10 native English speakers. Results showed that Mandarin speakers produced significantly less native-like stress patterns, although they did use all four acoustic correlates to …

Pan-Arctic Patterns In Black Carbon Sources And Fluvial Discharges Deduced From Radiocarbon And Pah Source Apportionment Markers In Estuarine Surface Sediments, Marie Elmquist, Igor Semiletov, Laodong Guo, Örjan Gustafsson

Faculty Publications

A pan-arctic geospatial picture of black carbon (BC) characteristics was obtained from the seven largest arctic rivers by combining with molecular combustion markers (polycyclic aromatic hydrocarbons) and radiocarbon ((14)C) analysis. The results suggested that the contribution from modern biomass burning to BC ranged from low in the Yukon (8%) and Lena (5%) Rivers to high in the Yenisey River (88%). The Mackenzie River contributed almost half of the total arctic fluvial BC export of 202 kton a(-1) (kton = 10(9) g), with the five Russian-Arctic rivers contributing 10-36 kton a(-1) each. The (14)C-based source estimate of fluvially exported BC to …

Neuroprotection Via Matrix-Trophic Coupling Between Cerebral Endothelial Cells And Neurons, Shuzhen Guo, Woo Jean Kim, Josephine Lok, Sun Ryung Lee, Elaine Besancon, Bing Hao Luo, Monique F. Stins, Xiaoying Wang, Shoukat Dedhar, Eng H. Lo

Faculty Publications

The neurovascular unit is an emerging concept that emphasizes homeostatic interactions between endothelium and cerebral parenchyma. Here, we show that cerebral endothelium are not just inert tubes for delivering blood, but they also secrete trophic factors that can be directly neuroprotective. Conditioned media from cerebral endothelial cells broadly protects neurons against oxygen-glucose deprivation, oxidative damage, endoplasmic reticulum stress, hypoxia, and amyloid neurotoxicity. This phenomenon is largely mediated by endothelial-produced brain-derived neurotrophic factor (BDNF) because filtering endothelial-conditioned media with TrkB-Fc eliminates the neuroprotective effect. Endothelial production of BDNF is sustained by β-1 integrin and integrin-linked kinase (ILK) signaling. Noncytotoxic levels of …