Digital Commons Network^™

Improving Patient-Centered Care: Personal Models Of Depression Among Older Male Veterans, Erin Woodhead, Sarah Brunskill, J. Lisa Tenover, Joung Huh

Faculty Publications

A quality improvement project was undertaken at the Geriatric Research Education and Clinical Center at the VA Palo Alto Health Care System to better understand how older veterans think about depression diagnosis and treatment so that patient education efforts and communication between older veterans and their health care providers could be improved.

Spending Today Or Saving For Tomorrow: The Influence Of Family Financial Socialization On Financial Preparation For Retirement, Scott H. Payne, Jeremy B. Yorgason, Jeffrey P. Dew

Faculty Publications

Many of the factors that motivate individuals occur within the context of the family, and can be influenced through family socialization processes. To better understand the influence family socialization processes may have on financial capabilities and financial behaviors, 334 married couples were sampled. Structural equation modeling was used to examine both direct and indirect associations. Findings indicated direct relationships between materialism and financial strain, between religiosity and determination of needs, and between financial strain and saving for retirement. Indirect relationships were found between materialism and saving for retirement through financial strain. Our study found evidence to support the Family Financial …

A Meta-Analysis Identifies New Loci Associated With Body Mass Index In Individuals Of African Ancestry, Keri L. Monda, Gary K. Chen, Kira C. Taylor, Cameron Palmer, Todd L. Edwards, Leslie A. Lange, Maggie C.Y. Ng, Adebowale A. Adeyemo, Matthew A. Allison, Lawrence F. Bielak, Guanjie Chen, Mariaelisa Graff, Marguerite R. Irvin, Suhn K. Rhie, Guo Li, Yongmei Liu, Youfang Liu, Yingchang Lu, Michael A. Nalls, Yan V. Sun, Mary K. Wojczynski, Lisa R. Yanek, Melinda C. Aldrich, Adeyinka Ademola, Christopher I. Amos, Elisa V. Bandera, Cathryn H. Bock, Angela Britton, Ulrich Broeckel, Quiyin Cai, Neil E. Caporaso, Chris S. Carlson, John Carpten

Faculty Publications

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a …

Endothelial Activation Microparticles And Inflammation Status Improve With Exercise Training In African Americans, Dianne M. Babbitt, Keith M. Diaz, Deborah L. Feairheller, Kathleen M. Sturgeon, Amanda M. Perkins, Praveen Veerabhadrappa, Sheara T. Williamson, Jan Krezschmar, Chenyi Ling, Hojun Lee, Heather Grimm, Sunny R. Thakkar

Faculty Publications

African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 (IL-10), interleukin-6 (IL-6), and endothelial microparticle (EMP) CD62E+ and endothelial function assessed by flow-mediated dilation (FMD) in African Americans. A secondary purpose was to evaluate whether changes in IL-10, IL-6, or CD62E+ EMPs predicted the change in FMD following the 6-month AEXT intervention. A pre-post design was employed with baseline evaluation including office blood pressure, FMD, …

An Extract Of Artemisia Dracunculus L. Inhibits Ubiquitin-Proteasome Activity And Preserves Skeletal Muscle Mass In A Murine Model Of Diabetes, Heather Kirk-Ballard, Zhong Q. Wang, Priyanka Acharya, Xian H. Zhang, Yongmei Yu, Gail Kilroy, David Ribnicky, William T. Cefalu, Z. Elizabeth Floyd

Faculty Publications

Impaired insulin signaling is a key feature of type 2 diabetes and is associated with increased ubiquitin-proteasome-dependent protein degradation in skeletal muscle. An extract of Artemisia dracunculus L. (termed PMI5011) improves insulin action by increasing insulin signaling in skeletal muscle. We sought to determine if the effect of PMI5011 on insulin signaling extends to regulation of the ubiquitin-proteasome system. C2C12 myotubes and the KK-Ay murine model of type 2 diabetes were used to evaluate the effect of PMI5011 on steady-state levels of ubiquitylation, proteasome activity and expression of Atrogin-1 and MuRF-1, muscle-specific ubiquitin ligases that are upregulated with impaired insulin …

Occupational Engagement And Health In Older South Asian Immigrants, Sheama R. Krishnagiri, Erin Fuller, Lesley Ruda, Sadhna Diwan

Faculty Publications

The purpose of this study was to investigate the elements that shape how healthy active South Asian elder immigrants engage in daily activities to maintain their health. A descriptive grounded theory approach was employed using semi-structured interviews and a daily activity chart. Convenience sampling was used to recruit 12 South Asian elders, 7 males and 5 females, who immigrated after retirement to the South San Francisco Bay area. Open, axial, and selective coding of the transcribed data led to two broad themes, control and interdependence. These themes may be viewed as dynamic and interconnected forces that shape and determine the …

Adolescent And Parent Perceptions Of The Influence Of Religious Belief And Practice, Carrolyn A. Mcmurdie, David C. Dollahite, Sam A. Hardy

Faculty Publications

The purpose of the present study was to investigate lay conceptions of religious influence. Specifically, we explored adolescents' and parents' perceptions of the ways in which their religious beliefs and practices had impacted them and their life. The sample included 419 adolescents and 282 parents recruited from across the United States through an online survey panel. Participants were asked to list three different ways that religion had influenced their lives. Responses were coded using grounded-theory qualitative methods. Six main themes of influence emerged in both the adolescent and parent responses: Interpersonal Relationships, Character Development, Religious Values and Practices, Perspective, Peace …

Stress Spillover Of Health Symptoms From Healthy Spouses To Patient Spouses In Older Married Couples Managing Both Diabetes And Osteoarthritis, Jeremy B. Yorgason, Susanne O. Roper, Jonathan G. Sandberg, Cynthia A. Berg

Faculty Publications

Many studies examining illness within marriage have investigated how illness in one spouse influences the other spouse. In later-life marriages, where both spouses are more likely to have health challenges, there is an increased likelihood that health symptoms from both spouses affect each other. In the current study we examined how health symptoms in a “healthy” spouse may exacerbate health problems in a partner (the patient) who is managing multiple chronic illnesses. Surveys were collected across 14 days from 27 later-life couples where patients had both diabetes and osteoarthritis. Results indicated that higher healthy spouse symptoms were generally associated with …

Body Mass Index Trajectories From Adolescence To Midlife: Differential Effects Of Parental And Respondent Education By Race/Ethnicity And Gender, Katrina M. Walsemann, Jennifer A. Ailshire, Bethany A. Bell, Edward A. Frongillo

Faculty Publications

Objectives: Race/ethnicity and education are among the strongest social determinants of body mass index (BMI) throughout the life course, yet we know relatively little about how these social factors both independently and interactively contribute to the rate at which BMI changes from adolescence to midlife. The purpose of this study is to 1) examine variation in trajectories of BMI from adolescence to midlife by mothers' and respondents' education, and 2) determine if the effects of mothers' and respondents' education on BMI trajectories differ by race/ethnicity and gender.

Design: We used nationally representative data from the National Longitudinal Survey of Youth …

Telomere Maintenance Genes Sirt1 And Xrcc6 Impact Age-Related Decline In Telomere Length But Only Sirt1 Is Associated With Human Longevity, Sangkyu Kim, Xiuhua Bi, Malwina Czarny-Ratajczak, Jianliang Dai, David A. Welsh, Leann Myers, Michael A. Welsch, Katie E. Cherry, Jonathan Arnold, Leonard W. Poon, Michal Jazwinski

Faculty Publications

Leukocyte telomere length is widely considered a biomarker of human age and in many studies indicative of health or disease. We have obtained quantitative estimates of telomere length from blood leukocytes in a population sample, confirming results of previous studies that telomere length significantly decreases with age. Telomere length was also positively associated with several measures of healthy aging, but this relationship was dependent on age. We screened two genes known to be involved in telomere maintenance for association with the age-related decline in telomere length observed in our population to identify candidate longevity-associated genes. A single-nucleotide polymorphism located in …

Integrating Advanced Writing Content Into A Scholarly Inquiry In Nursing Course, Barbara L. Madleco

Faculty Publications

Since there are few data examining methods to help students learn to write in a scholarly manner, the purposes of this project were to (1) evaluate students’ learning of writing content integrated into a Scholarly Inquiry in Nursing course by examining differences in scores on a writing assessment taken at the beginning and end of the course; and (2) examine student confidence ratings relative to writing to see if it improved during the course. After obtaining IRB approval and informed consent, the CLIPS pre and post assessment mean scores of 82 students in a Scholarly Inquiry in Nursing course were …

Developing Positive Attitudes Toward Geriatric Nursing Among Millennials And Generations Xers, Barbara A. Heise, Vickie Johnsen, Deborah O. Himes, Debra Wing

Faculty Publications

Despite the increase of the older adult population, there exists a shortage of health care professionals trained to help this population remain independent as long as possible. Ageism, common among younger adults, affects the capacity building of health care for older adults. Research has indicated that increased knowledge about older adults, as well as exposure to the elderly, may alter nursing students' attitudes regarding careers in gerontological nursing. However, questions remain as to what are the most effective ways to provide gerontological content in nursing programs and enhance attitudes toward older adults. With the understanding that younger adults see a …

Psychological Pathways Linking Social Support To Health Outcomes: A Visit With The “Ghosts” Of Research Past, Present, And Future, Wendy C. Birmingham, Bert N. Uchino, Kimberly Bowen, Mckenzie Carlisle

Faculty Publications

Contemporary models postulate the importance of psychological mechanisms linking perceived and received social support to physical health outcomes. In this review, we examine studies that directly tested the potential psychological mechanisms responsible for links between social support and health-relevant physiological processes (1980s to 2010). Inconsistent with existing theoretical models, no evidence was found that psychological mechanisms such as depression, perceived stress, and other affective processes are directly responsible for links between support and health. We discuss the importance of considering statistical/design issues, emerging conceptual perspectives, and limitations of our existing models for future research aimed at elucidating the psychological mechanisms …

Important Information Literacy Standards For Life And Health Sciences, Betsy S. Hopkins

Faculty Publications

Information literacy in the life and health sciences is a dynamic field, with challenges, opportunities, and rewards for the successful practitioner. This chapter will describe the big picture of information literacy in these disciplines, list relevant performance indicators from the ALA/ACRL/STS Task Force on Information Literacy for Science and Technology [STS-TFILST] (2006) Information Literacy Standards for Science and Technology (hereafter Standards), and give some practical advice for life and health sciences librarians and librarians with instructional responsibilities in those disciplines. The focus is on undergraduates at research universities, although many principles and strategies will apply to other circumstances.

Association Between C-Reactive Protein And Cognitive Deficits In Elderly Men And Women: A Meta-Analysis, Bruce L. Brown, Dawson W. Hedges, Thomas J. Farrer

Faculty Publications

Abstract

Background: Certain risk factors for cognitive decline appear modifiable. A potentially modifiable marker of inflammation, C-reactive protein may be associated with cognitive deficits, although not all studies have found a relationship between C-reactive protein and cognitive ability. Further, few research papers have examined whether gender may affect any association between C-reactive protein and cognitive deficit.

Methods: To better understand the association between C-reactive protein, cognitive deficit, and gender in elderly people, we meta-analyzed cross-sectional studies that reported cognitive ability assessed by the Mini-Mental State Examination or an equivalent measure, C-reactive protein concentrations, and gender.

Results: While we identified no …

Subliminal Activation Of Social Ties Moderates Cardiovascular Reactivity During Acute Stress, Wendy C. Birmingham, Mckenzie Carlisle, Bert N. Uchino, David M. Sanbonmatsu, Timothy W. Smith, Matthew R. Cribbet, Kathleen C. Light, Allison A. Vaughn

Faculty Publications

Objective—The quality of one’s personal relationships has been reliably linked to important physical health outcomes, perhaps through the mechanism of physiological stress responses. Most studies of this mechanism have focused on whether more conscious interpersonal transactions influence cardiovascular reactivity. However, whether such relationships can be automatically activated in memory to influence physiological processes has not been determined. The primary aims of this study were to examine if subliminal activation of relationships could influence healthrelevant physiological processes, and to examine this question in the context of a more general relationship model that incorporates both positive and negative dimensions. Method—We randomly assigned …

Social Relationships And Mortality, Julianne Holt-Lunstad, Timothy B. Smith

Faculty Publications

Social relationships benefit not only mental health but also physical health. This review addresses the following questions: (1) What is the overall magnitude of the effect of social relationships on risk for premature death? (2) How generalized is the effect and are there factors known to influence this association? (3) What are the likely pathways by which social relationships influence longevity? The article concludes by discussing the implications of these findings for potential interventions aimed at reducing risk for mortality.

Longitudinal Assessment Of Cognitive And Psychosocial Functioning After Hurricanes Katrina And Rita: Exploring Disaster Impact On Middle-Aged, Older, And Oldest-Old Adults, Katie E. Cherry, Jennifer Silva Brown, Loren D. Marks, Sandro Galea, Julia Volaufova, Christina Lefante, L. Joseph Su, David A. Welsh, S. Michal Jazwinski, Meghan B. Allen, Gloria Anderson, Iina E. Antikainen, Arturo M. Arce, Jennifer Arceneaux, Mark A. Batzer, Emily O. Boudreaux, Lauri Byerley, Catherine M. Champagne, Liliana Cosenza, M. Elaine Cress, Jenny Y. Denver, Andy Deutsch, Devon A. Dobrosielski, Rebecca Ellis, Marla J. Erwin, Mark Erwin, Jennifer Fabre, Elizabeth T. Fontham, Madlyn Frisard, Paula Geiselman, Lindsey Goodwin, Tiffany Hall, Scott W. Herke, Jennifer Hayden

Faculty Publications

The authors examined the effects of Hurricanes Katrina and Rita on cognitive and psychosocial functioning in a lifespan sample of adults 6-14 months after the storms. Participants were recruited from the Louisiana Healthy Aging Study. Most were assessed during the immediate impact period and retested for this study. Analyses of pre- and post-disaster cognitive data confirmed that storm-related decrements in working memory for middle-aged and older adults observed in the immediate impact period had returned to pre-hurricane levels in the post-disaster recovery period. Middle-aged adults reported more storm-related stressors and greater levels of stress than the two older groups at …

Affording Emerging Adulthood: Parental Financial Assistance Of Their College-Aged Children, Laura M. Padilla-Walker, Larry J. Nelson, Jason S. Carroll

Faculty Publications

The purpose of this study was to examine parents’ attitudes about and patterns of providing financial assistance to their children during college, and how varying levels of parental financial support were related to children’s beliefs (e.g., perceptions of adulthood), behaviors (e.g., work hours, drinking, and drug use), and identity development. The sample consisted of 402 undergraduate students (62% women) recruited from four college sites across the United States (M age = 19.89), and one of their parents (310 mothers and 92 fathers). Using cluster analysis, results suggested four distinct approaches to parental financial involvement and found that emerging adults’ …

Shaping A Lfe Of Significance For Retirement By R. Jack Hansen And Jerry P. Haas, E Michael Brady Phd

Faculty Publications

The article reviews the book Shaping a Life of Significance for Retirement, by R. Jack Hansen and Jerry P. Haas.

Caloric Restriction, Aerobic Exercise Training And Soluble Lectin-Like Oxidized Ldl Receptor-1 Levels In Overweight And Obese Post-Menopausal Women, Tina E. Brinkley, Xuewen Wang, Noriaki Kume, Hirokazu Mitsuoka, Barbara J. Nicklas

Faculty Publications

Background—Elevated circulating levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) have been observed in obese persons and are reduced by weight loss. However, it is not known if combining caloric restriction (CR) with exercise training is better in reducing sLOX-1 levels than CR alone.

Objective—We examined whether the addition of aerobic exercise to a weight loss intervention differentially affects sLOX-1 levels in 61 abdominally obese postmenopausal women randomly assigned to a CR only (n=22), CR + moderate-intensity exercise (n=22), or CR + vigorous intensity exercise (n=17) intervention for 20 weeks. The caloric deficit was ~2,800 kcal/week for …

Bmi Trajectories During The Transition To Older Adulthood: Persistent, Widening, Or Diminishing Disparities By Ethnicity And Education?, Katrina M. Walsemann, Jennifer A. Ailshire

Faculty Publications

Previous research has produced inconsistent results on whether education and ethnic disparities in BMI persist, widen, or diminish over time. We investigate how education and ethnicity, independently and conditionally, influence BMI trajectories during the transition to older adulthood. Employing random coefficient modeling, we analyzed 8 biennial waves of data (1992-2006) from the Health and Retirement Study, a nationally representative longitudinal study of individuals born between 1931 and 1941. After adjusting for health behaviors and health status, education and ethnic disparities in BMI persisted for most groups, but narrowed between high-educated white men and both low-educated Hispanic men and high-educated black …

Metabolic Restructuring During Energy-Limited States: Insights From Artemia Franciscana Embryos And Other Animals, Steven C. Hand, Michael A. Menze, Apu Borcar, Yuvraj Patil, Joseph A. Covi, Julie A. Reynolds, Mehmet Toner

Faculty Publications

Many life history stages of animals that experience environmental insults enter developmental arrested states that are characterized by reduced cellular proliferation, with or without a concurrent reduction in overall metabolism. In the case of the most profound metabolic arrest reported in invertebrates, i.e., anaerobic quiescence in Artemia franciscana embryos, acidification of the intracellular milieu is a major factor governing catabolic and anabolic downregulation. Release of ions from intracellular compartments is the source for approximately 50% of the proton equivalents needed for the 1.5 unit acidification that is observed. Recovery from the metabolic arrest requires re-sequestration of the protons with a …

Skin Blood Flow Response To 2-Hour Repositioning In The Long-Term Care Residents: A Pilot Study, Vivian K. Wong

Faculty Publications

PURPOSE: The purpose of this noninvasive pilot study was to examine the changes in transcutaneous oxygen (tcO2), skin temperature, and hyperemic response in the heels, sacrum, and trochanters in a 2-hour loading-unloading condition in nursing home residents who are positioned in supine and lateral positions. DESIGN: A 1-group, prospective, repeated-measures design was used. SUBJECTS AND SETTING: Nine subjects (5 males, 4 females) with a mean age of 85.3 ± 10.86 years (mean ± SD) who required help in turning and positioning at a skilled nursing facility participated in the study. METHODS: Oxygen and temperature sensors were placed on the heels, …

Decisional Strategy Determines Whether Frame Influences Treatment Preferences For Medical Decisions, Erin L. Woodhead, E. B. Lynch, B. A. Edelstein

Faculty Publications

Decision makers are influenced by the frame of information such that preferences vary depending on whether survival or mortality data are presented. Research is inconsistent as to whether and how age impacts framing effects. This paper presents two studies that used qualitative analyses of think-aloud protocols to understand how the type of information used in the decision making process varies by frame and age. In Study 1, 40 older adults, age 65 to 89, and 40 younger adults, age 18 to 24, responded to a hypothetical lung cancer scenario in a within-subject design. Participants received both a survival and mortality …

Acute Impact Of Moderate-Intensity And Vigorous-Intensity Exercise Bouts On Daily Physical Activity Energy Expenditure In Postmenopausal Women, Xuewen Wang, Barbara J. Nicklas

Faculty Publications

This study determined whether performing a single moderate- or vigorous-intensity exercise bout impacts daily physical activity energy expenditure (PAEE, by accelerometer). Overweight/obese postmenopausal women underwent a 5-month caloric restriction and moderate- (n = 18) or vigorous-intensity (n = 18) center-based aerobic exercise intervention. During the last month of intervention, in women performing moderate-intensity exercise, PAEE on days with exercise (577.7 ± 219.7 kcal·d⁻¹) was higher (P = .011) than on days without exercise (450.7 ± 140.5 kcal·d⁻¹); however, the difference (127.0 ± 188.1 kcal·d⁻¹) was much lower than the energy expended …

Obesity And Overweight Prevalence Among A Mississippi Low-Income Preschool Population: A Five-Year Comparison, Bonnie Harbaugh, Jerome R. Kolbo, Elaine F. Molaison, Geoffrey M. Hudson, Lei Zhang, Danyell Wells

Faculty Publications

Purpose. This study determined 2010 rates of overweight/obesity in a representative sample of low-income preschoolers in Mississippi, USA and compared rates between 2005 (� = 1 2 5 0) and 2010 (� = 1 7 6 5). Significance. Obesity is a significant global health issue because of its well-established negative health consequences. Child obesity is a concern due to risk of early-onset obesity-related illnesses and the longevity of lifetime exposure to those illnesses. Methods. Identical measures were used in 2005 and 2010 with complex-stratified sampling designs. Results. Chi-square tests revealed that overall obesity/overweight rates between 2005 (20.6%/17.9%) and 2010 (20.8%/17.0%) …

Self-Rated Health Status And Cardiorespiratory Fitness As Predictors Of Mortality In Men, Jennifer Gander, Duck-Chul Lee, Xuemei Sui, James R. Hébert, Steven P. Hooker, Steven N. Blair

Faculty Publications

Self-rated health (SRH) and cardiorespiratory fitness (fitness) are independent risk factors for all-cause mortality. The purpose of this report is to examine the single and joint effects of these exposures on mortality risk. The study included 18 488 men who completed a health survey, clinical examination and a maximal exercise treadmill test during 1987–2003. Cox regression analysis was used to quantify the associations of SRH and fitness with all-cause mortality. There were 262 deaths during 17 years of follow-up. There was a significant inverse trend (p_trend <0.05) for mortality across SRH categories after adjustment for age, examination year, body mass index, physical activity, smoking, alcohol consumption, abnormal ECG, hypertension, hypercholesterolaemia, cardiovascular disease, diabetes and cancer. Adjustment for fitness attenuated the association (p value =0.09). The authors also observed an inverse association between fitness and mortality after controlling for the same covariates and SRH (p_trend = 0.006). The combined analysis of SRH and fitness showed that fit …

Australian Family Leisure: Modelling Parent And Youth Data, Raymond A. Poff, Ramon Zabriskie, Jasmine A. Townsend

Faculty Publications

The purpose of this study was to test a recently developed broad structural model which examines the relationships between family leisure involvement, family functioning, family communication, family leisure satisfaction, and satisfaction with family life among a large sample of families from Australia (n = 1014). participating families provided responses to family variables from both a parent (n = 902) and an adolescent child (n = 810) in the household. Structural equation modelling was employed and the fit indices from the parent and youth structural equation models were quite similar to each other, with both exhibiting a reasonable fit of the …

Social Support And The Reactivity Hypothesis: Conceptual Issues In Examining The Efficacy Of Received Support During Acute Psychological Stress, Wendy C. Birmingham, Bert N. Uchino, Mckenzie Carlisle, Allison A. Vaughn

Faculty Publications

Social support has been reliably related to better physical health outcomes. One influential model suggests that social support is related to lower cardiovascular disease mortality because it reduces the potentially deleterious consequences of cardiovascular reactivity during acute stress. However, received support and perceived support are separable constructs and epidemiological research suggests variability in links between received support and health. This is important because most social support and acute laboratory stress studies are essentially based on the receipt of support. In this paper, we focus on the conceptualization of received support and its implications for understanding links to support laboratory reactivity …