Digital Commons Network^™

Demographic Disparities In Clinical Outcomes Of Covid-19: Data From A Statewide Cohort In South Carolina, Xueying Yang, Jiajia Zhang Ph.D., Shujie Chen, Bankole Olatosi Ph.D., Larisa Bruner, Abdoulaye Diedhiou, Cheryl Scott, Ali Mansaray, Sharon Weissman, Xiaoming Li Ph.D.

Faculty Publications

Background:

Current literature examining the clinical characteristics of coronavirus disease 2019 (COVID-19) patients under-represent COVID-19 cases who were either asymptomatic or had mild symptoms.

Methods:

We analyzed statewide data from 280 177 COVID-19 cases from various health care facilities during March 4-December 31, 2020. Each COVID-19 case was reported using the standardized Case Report Form (CRF), which collected information on demographic characteristics, symptoms, hospitalization, and death. We used multivariable logistic regression to analyze the associations between sociodemographics and disease severity, hospitalization, and mortality.

Results:

Among a total of 280 177 COVID-19 cases, 5.2% (14 451) were hospitalized and 1.9% (5308) …

Are The Dead Sea Scrolls From Khirbet Qumran?, Kenneth Atkinson

Faculty Publications

The Dead Sea Scrolls continue to remain the subject of an intense academic debate concerning their interpretation, their authors, and whether there is a connection between the caves in which these documents were discovered and the archaeological site of Khirbet Qumran. The answers to these questions are important because of the unprecedented number of fragmentary documents in this collection and their diverse contents. Because Roland de Vaux found the same types of pottery in the Scroll caves that he uncovered inside Khirbet Qumran, most scholars view the Scrolls as archaeological objects that are associated with this settlement. Khirbet Qumran’s architectural …

Through The Looking Glass: Longitudinal Evidence Providing New Insight For Motor Competence And Health, Lisa M. Barnett, E. Kipling Webster, Ryan M. Hulteen, An V. De Meester, Nadia C. Valentini, Matthieu Lenoir, Caterina Pesce, Nancy Getchell, Vitor P. Lopes, Leah E. Robinson, Ali Brian, Luis P. Rodrigues

Faculty Publications

Introduction In 2008, a conceptual model explaining the role of motor competence (MC) in children’s physical activity (PA), weight status, perceived MC and health-related fitness was published.

Objective The purpose of the current review was to systematically compile mediation, longitudinal and experimental evidence in support of this conceptual model.

Methods This systematic review (registered with PROSPERO on 28 April 2020) was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement. Separate searches were undertaken for each pathway of interest (final search 8 November 2019) using CINAHL Complete, ERIC, Medline (OVID), PsycINFO, Web of Science …

Ocean Regime Shift Is Driving Collapse Of The North Atlantic Right Whale Population, Erin L. Meyer-Gutbrod, Charles H. Greene, Kimberley T.A. Davies, David G. Johns

Faculty Publications

Ocean warming linked to anthropogenic climate change is impacting the ecology of marine species around the world. In 2010, the Gulf of Maine and Scotian Shelf regions of the Northwest Atlantic underwent an unprecedented regime shift. Forced by climate-driven changes in the Gulf Stream, warm slope waters entered the region and created a less favorable foraging environment for the endangered North Atlantic right whale population. By mid-decade, right whales had shifted their late spring/summer foraging grounds from the Gulf of Maine and the western Scotian Shelf to the Gulf of St. Lawrence. The population also began exhibiting unusually high …

Honoring The Mother Of All People; Contemporary Indigenous Leadership In Revitalizing Environmental And Cultural Sustainability, Katharine A. Duderstadt, Alexandra G. Martin, Svetlana Peshkova, Siobhan Senier, Jennifer F. Brewer, Daniel R. Howard

Faculty Publications

This series of events brings Indigenous perspectives from 22 Indigenous speakers across the U.S. and Arctic regions to discussions of sustainable futures within the New Hampshire community. There is growing movement in the academic community to understand how Indigenous knowledge and cultural heritage can deepen our thinking about sustainable futures. While most researchers recognize that anthropogenic climate change and other sustainability challenges require humanistic as well as scientific approaches, many have yet to thoroughly understand the colonial legacies that initiated many of these sustainability problems and continue to impede our study and solutions. The 2020-2021 Sidore Series was designed to …

Bright And Blind Spots Of Water Research In Latin America And The Caribbean, Alyssa J. Devincentis, Hervé Guillon, Romina Díaz Gómez, Noelle K. Patterson, Francine Van Den Brandeler, Srthur Koehl, Pablo Ortiz-Partida, Laura E. Garza-Díaz, Jennifer Gamez-Rodríguez, Erfan Goharian, Samuel Sandoval Solis

Faculty Publications

Water resources management in Latin America and the Caribbean is particularly threatened by climatic, economic, and political pressures. To assess the region's ability to manage water resources, we conducted an unprecedented literature review of over 20 000 multilingual research articles using machine learning and an understanding of the socio-hydrologic landscape. Results reveal that the region's vulnerability to water-related stresses, and drivers such as climate change, is compounded by research blind spots in niche topics (reservoirs and risk assessment) and subregions (Caribbean nations), as well as by its reliance on an individual country (Brazil). A regional bright spot, Brazil, produces well-rounded …

Bidirectional Relationships Among Children’S Perceived Competence, Motor Skill Competence, Physical Activity, An Cardiorespiratory Fitness Across One School Year, Suryeon Ryu, Jung Eun Lee, Nan Zeng, David F. Stodden, Daniel J. Mcdonough, Wenxi Liu, Zan Gao

Faculty Publications

Purpose. The bidirectional associations among children’s motor skill competence (MSC), perceived competence (PC), physical activity (PA), and cardiorespiratory fitness (CRF) over time remain unanswered. This study is aimed at discerning the bidirectional relationships among elementary school children’s MSC, PC, PA and, CRF over the course of one school year. Methods. A total of 261 second and third grade children (127 boys, 134 girls; mean_age = 8.27 years; BMI = 18.22 ± 3.71) were recruited from two Texas elementary schools. Approximately 73.56% of participants were White American. Children’s baseline data were assessed in September/October in 2012 (Time1), and …

Dependence On Humidity And Aerosol Composition Of The Gas-Particle Partitioning Of Weakly And Moderately Polar Vocs, Jeonghyeon Ahn, Guiying Rao, Eric P. Vejerano

Faculty Publications

Volatile organic compounds (VOCs) dominate the class of pollutants that accumulate in the atmosphere and indoors. Assessing the gas-particle partitioning of VOCs is important to determine their fate, transport, and adverse health impacts. This work is a companion to our earlier study on the temperature dependence of VOC partitioning. Here, we report our measurement of the gas-particle partition coefficient (Kp) for weakly polar (trichloroethylene, TCE) and moderately polar (n-butanol, n-BuOH) VOCs under varying relative humidity (RH) levels onto organic and inorganic aerosols. Kp of TCE was four to five orders of magnitude lower than those …

Rgb Indices And Canopy Height Modelling For Mapping Tidal Marsh Biomass From A Small Unmanned Aerial System, Grayson R. Morgan, Cuizhen Wang, James T. Morris

Faculty Publications

Coastal tidal marshes are essential ecosystems for both economic and ecological reasons. They necessitate regular monitoring as the effects of climate change begin to be manifested in changes to marsh vegetation healthiness. Small unmanned aerial systems (sUAS) build upon previously established remote sensing techniques to monitor a variety of vegetation health metrics, including biomass, with improved flexibility and affordability of data acquisition. The goal of this study was to establish the use of RGB-based vegetation indices for mapping and monitoring tidal marsh vegetation (i.e., Spartina alterniflora) biomass. Flights over tidal marsh study sites were conducted using a multi-spectral camera on …

Sars-Cov-2 Impairs Dendritic Cells And Regulates Dc-Sign Gene Expression In Tissues, Guoshuai Cai, Mulong Du, Yohan Bossé, Helmut Albrecht, Fei Qin, Xizhi Luo, Xiao Michelle Androulakis, Chao Cheng, Mitzi Nagarkatti, Prakash Nagarkatti, David C. Christiani, Michael L. Whitfield, Christopher I. Amos, Feifei Xiao

Faculty Publications

The current spreading coronavirus SARS-CoV-2 is highly infectious and pathogenic. In this study, we screened the gene expression of three host receptors (ACE2, DC-SIGN and L-SIGN) of SARS coronaviruses and dendritic cells (DCs) status in bulk and single cell transcriptomic datasets of upper airway, lung or blood of COVID-19 patients and healthy controls. In COVID-19 patients, DC-SIGN gene expression was interestingly decreased in lung DCs but increased in blood DCs. Within DCs, conventional DCs (cDCs) were depleted while plasmacytoid DCs (pDCs) were augmented in the lungs of mild COVID-19. In severe cases, we identified augmented types of immature DCs (CD22+ …

Assessing Oral Language When Screening Multilingual Children For Learning Disabilities In Reading, J. Marc Goodrich, Lisa A. Fitton Ph.D., Jessica Chan, C. Jamie Davis

Faculty Publications

Multilingual children represent a rapidly growing population of students in U.S. schools. However, identification of language and learning disabilities for students from different linguistic backgrounds is complex, leading to frequent misidentification of multilingual learners for special education. This article provides guidance on how special education teachers, speech-language pathologists, and other practitioners (e.g., school psychologists) can utilize each other’s expertise to accurately assess language and literacy skills of multilingual learners. Five key lessons learned from research on identification of language disorders are presented, along with discussion of why these are important when screening multilingual children for learning disabilities in reading. Specifically, …

Merging Of Horizontally And Vertically Separated Small-Scale Buoyant Flames, Thomas H. Fletcher, Denver Haycock, Seth Tollefsen, David Lignell

Faculty Publications

The purpose of this study was to investigate the merging behavior of small-scale buoyant flames that might be representative of flames from a leaf in a shrub. Zirconia felt pads soaked in n-heptane were suspended on thin rods and spaced both horizontally and vertically. Time-dependent video images from flames from two-pad and three-pad configurations were analyzed to determine merging probability, combined flame characteristics (height, area, and width), and changes in burn time. Correlations of these combined flame characteristics were developed based on horizontal and vertical spacing between the pads. Merging probability correlated with an exponential function that was quadratic in …

Suicide Attempts In Us Veterans With Chronic Headache Disorders: A 10-Year Retrospective Cohort Study, X. Michelle Androulakis, Siyuan Guo, Jiajia Zhang Ph.D., Jason Sico, Peter Warren, Alec Giakas, Xiaoming Li Ph.D., B Lee Peterlin, Roy Mathew, Deborah Reyes

Faculty Publications

Objectives: A large-scale retrospective analysis of veterans with chronic pain was con-ducted to examine (1) the annual incidence of suicide attempts (SA) in veterans with chronic headache and other chronic pain conditions, and (2) the risk of SA in men and women with chronic headache and chronic headache concurrent with traumatic brain injury (TBI) as compared to non-headache chronic pain.

Methods: This retrospective study (N=3,247,621) analyzed National Veterans Affair Health Administrative data of patients diagnosed with chronic head, neck, back and other chronic pain from 2000 to 2010. Multivariable Poisson regression was used to explore the relative risks of SA …

‘Access Necessitates Being Seen’: Queer Visibility And Intersectional Embodiment Within The Health Information Practices Of Queer Community Leaders, Travis L. Wagner, Vanessa Kitzie

Faculty Publications

Navigating healthcare infrastructures is particularly challenging for queer-identifying individuals, with significant barriers emerging around stigma and practitioner ignorance. Further intersecting, historically marginalised identities such as one’s race, age or ability exacerbate such engagement with healthcare, particularly the access to and use of reliable and appropriate health information. We explore the salience of one’s queer identity relative to other embodied identities when navigating health information and care for themselves and their communities. Thirty semi-structured interviews with queer community leaders from South Carolina inform our discussion of the role one’s queer visibility plays relational to the visibility of other identities. We find …

Drivers Of Food Choice Among Children And Caregivers In Post-Earthquake Nepal, Pepijn Schreinemachers, Rachana Manadhar Sherestha, Bishal Gole, Dhruba Raj Bhattarai, Puspa Lal Ghimire, Bhishm P. Subedi, Tilman Brück, Ghassan Baliki, Ishwori P. Gautam, Christine E. Blake

Faculty Publications

Food systems in many countries are experiencing a shift from traditional foods toward processed foods high in sugar, fat and salt, but low in dietary fiber and micronutrients. There is an urgent need to better understand drivers of changing food behavior, particularly for lower-income countries. This study analyzes drivers of food choice among children and parents in rural Nepal. It uses qualitative data collected through key informant interviews and focus group discussions with school children, parents and teachers. The study reveals substantial changes in food behavior during the past decade with increased consumption of rice, meat, and highly processed snack …

Encirclement Of Moving Targets Using Noisy Range And Bearing Measurements, Cammy Peterson, Puneet Jain, Randal Beard

Faculty Publications

This paper presents theoretically justified controllers that use relative range and bearing measurements to steer a team of autonomous vehicles, operating without inertial position information, to circular trajectories around a constant-acceleration, constant-velocity, or stationary target. An extended Kalman filter is used to improve the noisy relative measurements and estimate the velocity of the moving target. These estimated values are used in the control laws to encircle constant-velocity moving targets. Lyapunov techniques are utilized to show that the vehicle will converge to the desired circular formations. Additionally, cooperating vehicles are shown to converge to a circular formation with equal temporal spacing …

Cardiovascular Health Trajectories And Elevated C-Reactive Protein: The Cardia Study, Jonathan J. Ruiz-Ramie, Jacob L. Barber, Donald M. Lloyd-Jones, Myron D. Gross, Jamal S. Rana, Stephen Sidney, David R. Jacobs Jr., Abbi D. Lane-Cordova, Mark A. Sarzynski Facsm

Faculty Publications

Background

Methods and Results

Knowledge Assessment Of Anti-Snake Venom Among Healthcare Practitioners In Northern Nigeria, Auwal A. Bala, Abubakar Jatau, Ismaeel Yunusa Ph.D., Mustapha Mohammed, Al-Kassim H. Mohammed, Abubakar M. Isa, Abubakar S. Wada, Kabiru A. Gulma, Inuwa Bello, Sani Malami

Faculty Publications

Introduction: Anti-snake venom (ASV) is the standard therapy for the management of snakebite envenoming (SBE). Therefore, the knowledge of ASV among healthcare practitioners (HCPs) is essential for achieving optimal clinical outcomes in snakebite management. This study aimed to assess knowledge of ASV among the HCPs in northern Nigeria.

Methods: We conducted a cross-sectional study involving eligible HCPs from different healthcare settings in northern Nigeria. The participants were recruited into the study using a combination of online (via Google Form) and face-to-face paper-based survey methods. The ASV knowledge of the respondents was measured using a validated anti-snake venom knowledge assessment tool …

A Systematic Review Of Datasets That Can Help Elucidate Relationships Among Gene Expression, Race, And Immunohistochemistry-Defined Subtypes In Breast Cancer., Ifeanyichukwu O. Nwosu, Stephen Piccolo

Faculty Publications

Scholarly requirements have led to a massive increase of transcriptomic data in the public domain, with millions of samples available for secondary research. We identified gene-expression datasets representing 10,214 breast-cancer patients in public databases. We focused on datasets that included patient metadata on race and/or immunohistochemistry (IHC) profiling of the ER, PR, and HER-2 proteins. This review provides a summary of these datasets and describes findings from 32 research articles associated with the datasets. These studies have helped to elucidate relationships between IHC, race, and/or treatment options, as well as relationships between IHC status and the breast-cancer intrinsic subtypes. We …

Cortical Microstructural Changes Associated With Treated Aphasia Recovery, Allen J. Chang, Janina Wilmonskoetter, Julius Fridriksson, Emilie R. Mckinnon, Lorelei P. Johnson, Alexandra Basilakos, Jens H. Jensen, Chris Rorden, Leonardo Bonilha

Faculty Publications

Objectives

To investigate the hypothesis that language recovery in post-stroke aphasia is associated with structural brain changes.

Methods

We evaluated whether treatment-induced improvement in naming is associated with reorganization of tissue microstructure within residual cortical regions. To this end, we performed a retrospective longitudinal treatment study using comprehensive language-linguistic assessments and diffusion MRI sequences optimized for the assessment of complex microstructure (diffusional kurtosis imaging) to evaluate the relationship between language treatment response and cortical changes in 26 individuals with chronic stroke-induced aphasia. We employed elastic net statistical models controlling for baseline factors including age, sex, and time since the stroke, …

Modern Archaeology And The Brass Plates, Noel B. Reynolds

Faculty Publications

Contemporary Palestinian archaeology has produced two major threats to traditional interpretations of the history of ancient Israel. Scientific discomfort with the exodus story as an explanation for the sudden population expansion in southern Palestine at the beginning of the Iron Age (c.1200 BCE) has led to a wide variety of theories about how these Israelites could have been drawn from existing populations in the general area. And a glaring mismatch between the biblical glorification of David and Solomon’s “empire” and disparagement of the northern kingdom combined with the archaeological finding that the cities of the northern kingdom were far larger …

Nephi's Small Plates: A Rhetorical Analysis, Noel B. Reynolds

Faculty Publications

Readers of the Book of Mormon commonly assume the adequacy of a simple and straight-forward explanation for the existence of Nephi’s Small Plates. As explained at various points in the text, Nephi had undertaken a shorter version of his Large Plates record by selecting out the spiritual teachings, prophecies and revelations for a more focused presentation. But the adequacy of that explanation has come under considerable strain from two very different directions. In 1986 Fred Axelgard advanced the idea that the description provided for the Large Plates of Nephi as being more historical also applied to all of First Nephi …

Lehi's Dream: Nephi's Blueprint, Noel B. Reynolds

Faculty Publications

This essay harnesses the late twentieth-century discovery of Hebrew rhetoric by Bible scholars to identify Lehi’s dream as the foundation of the carefully constructed unity in Nephi’s writings and to identify previously unrecognized elements of that dream that are distributed throughout his final work. All the teachings and prophecies in First and Second Nephi are shown to derive from that dream/vision. Further, the entirety of Nephi’s writings in the small plates are shown to be a tightly designed rhetorical production that establishes the centrality of Christ’s identity, mission, and teachings for current and future generations of Lehi’s descendants and ultimately …

Electrochemical Micro-Aptasensors For Exosome Detection Based On Hybridization Chain Reaction Amplification, Wenfen Zhang, Zhenhua Tian, Shujie Yang, Joseph Rich, Shuaiguo Zhao, Mikael Klingeborn, Po-Hsun Huang, Zhishang Li, Alexander Stout, Quinn Murphy, Edward Patz, Shusheng Zhang, Guozhen Liu, Tony Jun Huang

Faculty Publications

Exosomes are cell-derived nanovesicles that have recently gained popularity as potential biomarkers in liquid biopsies due to the large amounts of molecular cargo they carry, such as nucleic acids and proteins. However, most existing exosome-based analytical sensing methods struggle to achieve high sensitivity and high selectivity simultaneously. In this work, we present an electrochemical micro-aptasensor for the highly sensitive detection of exosomes by integrating a micropatterned electrochemical aptasensor and a hybridization chain reaction (HCR) signal amplification method. Specifically, exosomes are enriched on CD63 aptamer-functionalized electrodes and then recognized by HCR products with avidin-horseradish peroxidase (HRP) attached using EpCAM aptamers as …

An Everlasting Witness: Ancient Writings On Metal, Noel B. Reynolds

Faculty Publications

After reviewing and updating the best studies of writing on metals in the ancient world, the paper examines scholarly and scriptural texts that explain what writing on metal meant to ancient scribes. Finally, the paper turns to what writing on metal meant to the Nephites.

Lehi And Nephi As Trained Manassite Scribes, Noel B. Reynolds

Faculty Publications

This paper brings contemporary ANE scholarship in several fields together to construct an updated starting point for interpretation of the teachings of the Book of Mormon. It assembles findings from studies of ancient scribal culture, historical linguistics and epigraphy, Hebrew rhetoric, and the history and archaeology of Mesopotamia, Egypt, and the Levant, together with the traditions of ancient Israel to construct a contextualized perspective for understanding Lehi, Nephi, and their scribal training as they would have been understood by their contemporaries. Lehi and Nephi are shown to be the beneficiaries of the most advanced scribal training available in 7th century …

Extended Search For Supernovalike Neutrinos In Nova Coincident With Ligo/Virgo Detections, M. A. Acero, P. Adamson, L. Aliaga, N. Anfimov, A. Antoshkin, E. Arrieta-Diaz, L. Asquith, A. Aurisano, A. Back, C. Backhouse, M. Baird, N. Balashov, P. Baldi, B. A. Bambah, S. Bashar, K. Bays, R. Bernstein, V. Bhatnagar, B. Bhuyan, J. Bian, Roberto Petti, Et. Al.

Faculty Publications

A search is performed for supernovalike neutrino interactions coincident with 76 gravitational wave events detected by the LIGO/Virgo Collaboration. For 40 of these events, full readout of the time around the gravitational wave is available from the NOvA Far Detector. For these events, we set limits on the fluence of the sum of all neutrino flavors of F < 7(4) × 10¹⁰ cm⁻² at 90% C.L. assuming energy and time distributions corresponding to the Garching supernova models with masses 9.6ð27Þ M_^⊙. Under the hypothesis that any given gravitational wave event was caused by a supernova, this corresponds to a distance …

Chagas Disease In Hiv-Infected Patients: It’S Time To Consider The Diagnosis, Melissa Nolan Ph.D., Mph, Natasha S. Hochberg

Faculty Publications

No abstract provided.

Auditing Non-Gaap Measures: Signaling More Than Intended, Spencer B. Anderson, Jessen L. Hobson, Ryan D. Sommerfeldt

Faculty Publications

Many companies regularly disclose non-GAAP performance measures to communicate firm-specific information that does not fit within the mold of GAAP reporting. However, these non- GAAP measures may have low information content or even be misleading to investors. Thus, the question arises of whether auditors should play a larger role in the reporting of non-GAAP measures, which currently are not audited. We run an experiment to provide ex ante evidence on the effect of auditing non-GAAP measures. Specifically, we present investor-participants with a non- GAAP measure that should be used when making investment judgments (more informative) or should not be used …

Construction Industry Training Assessment Framework, Hazem Jadallah, Carol J. Friedland, Isabelina Nahmens, Charles Pecquet, Charles Berryman, Yimin Zhu

Faculty Publications

The construction industry suffers from a lack of structured assessment methods to consistently gauge the efficacy of workforce training programs. To address this issue, this study presents a framework for construction industry training assessment that identifies established practices rooted in evaluation science and developed from a review of archival construction industry training literature. Inclusion criteria for the evaluated studies are: archival training studies focused on the construction industry workforce and integration of educational theory in training creation or implementation. Literature meeting these criteria are summarized and a case review is presented detailing assessment practices and results. The assessment practices are …