Digital Commons Network^™

Agr2-Associated Er Stress Promotes Adherent-Invasive E. Coli Dysbiosis And Triggers Cd103+ Dendritic Cell Il-23-Dependent Ileocolitis, Monica Viladomiu, Manirath Khounlotham, Belgin Dogan, Svetlana F. Lima, Ahmed Elsaadi, Emre Cardakli, Jim G. Castellanos, Charles Ng, Jeremy Herzog, Alexi A. Schoenborn, Melissa Ellermann, Bo Liu, Shiying Zhang, Ajay S. Gulati, R. Balfour Sartor, Kenneth W. Simpson, Steven M. Lipkin, Randy S. Longman

Faculty Publications

Endoplasmic reticulum (ER) stress is associated with Crohn’s disease (CD), but its impact on host-microbe interaction in disease pathogenesis is not well defined. Functional deficiency in the protein disulfide isomerase anterior gradient 2 (AGR2) has been linked with CD and leads to epithelial cell ER stress and ileocolitis in mice and humans. Here, we show that ileal expression of AGR2 correlates with mucosal Enterobactericeae abundance in human inflammatory bowel disease (IBD) and that Agr2 deletion leads to ER-stress-dependent expansion of mucosal-associated adherent-invasive Escherichia coli (AIEC), which drives Th17 cell ileocolitis in mice. Mechanistically, our data reveal that AIEC-induced epithelial cell …

Pretreatment Of Corncob With Green Deep Eutectic Solvent To Enhance Cellulose Accessibility For Energy And Fuel Applications, Sanphawat Phromphithak, Nakorn Tippayawong, Thossaporn Onsree, Jochen A. Lauterbach

Faculty Publications

Fossil fuels are the primary source of energy for a long period in spite of excessive environmental hazards, such as greenhouse gas emissions. Production of energy and fuel from lignocellulosic biomass has been the goal of the study in pursuit of renewable alternatives to fossil materials. Corncob is common agricultural biomass waste found in many countries. It can be utilized to produce bioenergy, but the conversion efficiency is limited. Pretreatment may be applied to improve the efficiency of corncob conversion; for example, by the fractionation of lignocellulosic biomass. Choline chloride (ChCl) and glycerol are considered as synthetic deep eutectic solvents …

Privacy Qui Tam, Peter Ormerod

Faculty Publications

Privacy law keeps getting stronger, but surveillance-based businesses have proven immune to these new legal regimes. The disconnect between privacy law in theory and in practice is a multifaceted problem, and one critical component is enforcement.

Today, most privacy laws are enforced by governmental regulators—the Federal Trade Commission, the nascent California Privacy Protection Agency, and state attorneys general. An enduring impasse for proposed privacy laws is whether to supplement public enforcement by using a private right of action to authorize individuals to enforce the law.

Both of these conventional enforcement schemes have significant shortcomings. Public enforcement has proven inadequate because …

Meshless Large Eddy Simulation Of Propeller-Wing Interactions With Reformulated Vortex Particle Method, Eduardo Alvarez, Andrew Ning

Faculty Publications

The vortex particle method (VPM) has gained popularity in recent years due to a growing need to predict complex aerodynamic interactions during preliminary design of electric multirotor aircraft. However, VPM is known to be numerically unstable when vortical structures break down close to the turbulent regime. In recent work, the VPM has been reformulated as a large eddy simulation (LES) in a scheme that is both meshless and numerically stable, without increasing its computational cost. In this study, we build upon this meshless LES scheme to create a solver for interactional aerodynamics. Rotor blades are introduced through an actuator line …

Techno-Economic Sensitivity Analysis For Combined Design And Operation Of A Small Modular Reactor Hybrid Energy System, Daniel Hill, Adam Martin, Nathanael Martin-Nelson, Charles Granger, Kody Powell, John Hedengren

Faculty Publications

With increasing grid-penetration of renewable energy resources and a rising need for carbon-free dispatchable power generation, nuclear-hybrid energy systems (NHES), consisting of small modular reactors, are an increasingly attractive option for maintaining grid stability. NHES can accomplish this with a minimal carbon footprint but there are significant uncertainties that are not fully understood. This work describes and demonstrates methods for analyzing the uncertainties of potential NHES designs, including uncertain design parameters and time series as well as variations in dispatch horizon length. The proposed methods are demonstrated on a sample system with 16 design parameters, 3 uncertain time series, and …

A Hierarchy Of Interactions Between Pathogenic Virus And Vertebrate Host, Robert Friedman

Faculty Publications

This review is of basic models of the interactions between a pathogenic virus and vertebrate animal host. The interactions at the population level are described by a predatory-prey model, a common approach in the ecological sciences, and depend on births and deaths within each population. This ecological perspective is complemented by models at the genetical level, which includes the dynamics of gene frequencies and the mechanisms of evolution. These perspectives are symmetrical in their relatedness and reflect the idealized forms of processes in natural systems. In the latter sections, the general use of deep learning methods is discussed within the …

Dating App Facilitated Sexual Assault: A Retrospective Review Of Sexual Assault Medical Forensic Examination Charts, Julie L. Valentine, Leslie W. Miles, Kristen Mella Hamblin, Aubrey Worthen Gibbons

Faculty Publications

Dating app facilitated sexual assault (DAppSA) is a concerning phenomenon with minimal published research. This retrospective study explored if DAppSAs were different than other sexual assaults (SAs) committed by acquaintances through a review of 3,413 sexual assault medical forensic examination (SAMFE) charts from 2017 to 2020 in a Mountain West state in the United States. Routine Activities Theory and Confluence Model of sexual aggression provided the theoretical framework for the study. Inclusion criteria for DAppSA cases included (1) victim was 14 years of age or older; (2) victim indicated meeting the perpetrator on a dating app; (3) SA occurred at …

Elements For Successful Implementation Of A Clinic-Based Health Literacy Intervention, Mark M. Macauda, Michelle Angelique Arent, Mayank Sakhuja, Brooks Yelton Ma, Lmsw, Samuel Noblet, Delores Fedrick, Diana Zona, Cyndi New, William D. Isenhower, Abraham Wandersman, Daniela B. Friedman Ph.D.

Faculty Publications

Improving health literacy is a national public health priority. Given the context of the COVID-19 pandemic, it is even more critical for health and medical information to be clear and understandable for patients and their families. Clinic-based programs to improve health literacy need to be pragmatic, feasible, and helpful for the implementing clinic and patients. This paper describes the development, implementation, and evaluation of a pragmatic, clinic-based health literacy intervention in a safety-net clinic that serves uninsured and indigent patients. Study methods are guided by a previous pilot study and components recommended for pragmatic interventions. An electronic readiness assessment was …

Antibody Prevalence And Risk Factors Associated With Rickettsia Spp. In A Pediatric Cohort: Sfgr Remains Underdiagnosed And Underreported In El Salvador, Kyndall C. Dye-Braumuller, Marvin Stanley Rodríguez Aquino, Kia Zellars, Hanna Waltz, Madeleine Meyer, Lídua Gual-Gonzalez, Stella C.W. Self, Mufaro Kanyangarara, Melissa Nolan Ph.D., Mph

Faculty Publications

Spotted fever group rickettsioses (SFGR) are caused by a group of tick-borne pathogens that are increasing in incidence globally. These diseases are typically underreported and undiagnosed in low- and middle-income countries, and thus, have been classified as neglected bacterial pathogens. Countries with high poverty, low human development index score, and limited health infrastructure—like El Salvador in Central America—lack necessary surveillance for SFGR and other tick-borne pathogens. This paucity of baseline SFGR infection prevalence leaves vulnerable populations at risk of misdiagnosis. Further, tick-borne disease burdens in El Salvador are severely limited. To lay the foundation for tick-borne disease epidemiology in El …

A Five-Country Study Of Front- And Back-Of-Package Nutrition Label Awareness And Use: Patterns And Correlates From The 2018 International Food Policy Study, Jasmin Bhawra, Sharon I. Kirkpatrick, Marissa G. Hall, Lana Vanderlee, Jim Thrasher Ph.D., Ma, Ms, Alejandra Jáuregui De La Mota, David Hammond

Faculty Publications

Objective:

This study aimed to identify correlates of nutrition label awareness and use, particularly subgroup differences among consumers. Two label types were assessed: (1) nutrition facts tables (NFt) in Australia, Canada, Mexico, UK, and USA and (2) front-of-package (FOP) labels, including mandatory Guideline Daily Amounts (Mexico), voluntary Health Star Ratings (Australia) and voluntary Traffic Lights (UK). Design:

Respondents were recruited using Nielsen Consumer Insights Global Panel (n 21 586) and completed online surveys in November–December 2018. Linear regression and generalised linear mixed models examined differences in label use and awareness between countries and label type based on sociodemographic, knowledge-related and …

Process Evaluation Methods And Results From The Health In Pregnancy And Postpartum (Hipp) Randomized Controlled Trial, Sarah Wilcox Phd, Alicia A. Dahl, Alycia K. Boutté, Jihong Liu Sc.D., Kelsey Day, Gabrielle Turner-Mcgrievy Ph.D., Rd, Ellen Wingard

Faculty Publications

Background

Excessive gestational weight gain has increased over time and is resistant to intervention, especially in women living with overweight or obesity. This study described the process evaluation methods and findings from a behavioral lifestyle intervention for African American and white women living with overweight and obesity that spanned pregnancy (≤ 16 weeks gestation) through 6 months postpartum.

Methods

The Health in Pregnancy and Postpartum (HIPP) study tested a theory-based behavioral intervention (vs. standard care) to help women (N = 219; 44% African American, 29.1 ± 4.8 years) living with overweight or obesity meet weight gain guidelines in pregnancy and …

Friendship As The Primary Purpose Of Law, Michael P. Moreland

Faculty Publications

A significant aspect of the legacy of John Finnis is the restoration of friendship to a central place in moral, political, and legal theory building on the classical tradition in Plato, Aristotle, and Aquinas. This essay surveys the implications of friendship for law by way of exploring Finnis’s treatment of friendship in several of his works, including friendship as a condition for discourse, friendship as an especially important illustration of the central case, the relationship between friendship and the common good, and the place of civic friendship in a political community. The essay concludes with a discussion of friendship with …

Reconciling Copyright "Restoration" For Pre-1972 Foreign Sound Recordings With The Classics Protection And Access Act, Tyler T. Ochoa

Faculty Publications

When Congress first added sound recordings to the Copyright Act, it acted prospectively only: sound recordings fixed on or after February 15, 1972, received federal statutory copyright protection, while sound recordings fixed before February 15, 1972, were left to the vagaries of state law. This historic inequity was corrected in 2018 with enactment of the Classics Protection and Access Act (CPA), which provides sui generis protection to pre-1972 sound recordings that is similar, but not identical, to federal copyright protection. But there is a subset of pre-1972 sound recordings that already had federal copyright protection before the CPA was enacted: …

Higher Adherence To A Mediterranean Diet Is Associated With Improved Insulin Sensitivity And Selected Markers Of Inflammation In Individuals Who Are Overweight And Obese Without Diabetes, Surbhi Sood, Jack Feehan, Catherine Itsiopoulos, Kirsty Wilson, Magdalena Plebanski, David Scott, James Hébert Scd, Nitin Shivappa Mbbs, Mph, Ph.D., Aya Mousa, Elena S. George, Barbora De Courten

Faculty Publications

Insulin resistance (IR) and chronic low-grade inflammation are risk factors for chronic diseases including type 2 diabetes (T2D) and cardiovascular disease. This study aimed to investigate two dietary indices: Mediterranean Diet Score (MDS) and Dietary Inflammatory Index (DII®), and their associations with direct measures of glucose metabolism and adiposity, and biochemical measures including lipids, cytokines and adipokines in overweight/obese adults. This cross-sectional study included 65 participants (males = 63%; age 31.3 ± 8.5 years). Dietary intake via 3-day food diaries was used to measure adherence to MDS (0–45 points); higher scores indicating adherence. Energy-adjusted DII (E-DII) scores were calculated with …

The Global, Regional, And National Burden Of Benign Prostatic Hyperplasia In 204 Countries And Territories From 2000 To 2019: A Systematic Analysis For The Global Burden Of Disease Study 2019, Atalel Fentahun, Hannah Han, Behzad Abbasi, Mohsen Abbasi-Kangevari, Muktar Beshir Ahmed, Ismaeel Yunusa Ph. D., Et Al.

Faculty Publications

Background Benign prostatic hyperplasia is a common urological disease affecting older men worldwide, but comprehensive data about the global, regional, and national burden of benign prostatic hyperplasia and its trends over time are scarce. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated global trends in, and prevalence of, benign prostatic hyperplasia and disability-adjusted life-years (DALYs) due to benign prostatic hyperplasia, in 21 regions and 204 countries and territories from 2000 to 2019.

Methods This study was conducted with GBD 2019 analytical and modelling strategies. Primary prevalence data came from claims from …

A Latitudinal Signal In The Relationship Between Species Geographic Range Size And Climatic Niche Area, Tad Dallas, Andrew Kramer

Faculty Publications

Species with broader niches may have the opportunity to occupy larger geographic areas, assuming no limitations on dispersal and a relatively homogeneous environmental space. Here, we use data on a large set of mammal (n = 1225), bird (n = 1829) and tree (n = 341) species to examine the 1) relationship between geographic range size and climatic niche area, 2) influence of species traits on species departures from this relationship and 3) sensitivity of these relationships to how species range size and climatic niche area are estimated. We find positive geographic range size–climatic niche area relationships for all taxa, …

The Impact Of Meal Dietary Inflammatory Index On Exercise-Induced Changes In Airway Inflammation In Adults With Asthma, Katrina P. Mcdiarmid, Lisa G. Wood, John W. Upham, Lesley K. Macdonald-Wicks, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Hayley A. Scott

Faculty Publications

Research suggests exercise may reduce eosinophilic airway inflammation in adults with asthma. The Dietary Inflammatory Index (DII®) quantifies the inflammatory potential of the diet and has been associated with asthma outcomes. This study aimed to determine whether the DII of a meal consumed either before or after exercise influences exercise-induced changes in airway inflammation. A total of 56 adults with asthma were randomised to (1) 30–45 min moderate–vigorous exercise, or (2) a control group. Participants consumed self-selected meals, two hours pre- and two hours post-intervention. Energy-adjusted DII (E-DIITM) was determined for each meal, with meals then characterised as “anti-inflammatory” or …

Safe, Supportive Neighborhoods: Are They Associated With Childhood Oral Health?, Elizabeth L. Crouch, Joni Nelson, Radhika Ranganathan, Melinda A. Merrell, Amy Martin

Faculty Publications

Objective

There has been limited examination of how community-level supports may influence oral health metrics among children. The purpose of our study is to examine the association between two types of community-level positive childhood experiences and oral healthcare and oral health outcomes among children ages 6 to 17 years of age.

Methods

This study uses a cross-sectional data set from the 2018–2019 National Survey of Children's Health. Two oral health metrics were used: preventive dental care, measured as one or more preventive dental visits in the past 12 months, and tooth decay, measured as tooth decay or cavities in the …

Compassion X2, Andrea Luxton

Faculty Publications

No abstract provided.

Bias In Measurement Of Autism Symptoms By Spoken Language Level And Non-Verbal Mental Age In Minimally Verbal Children With Neurodevelopmental Disorders (Vol 13, 927847, 2022), Shuting Zheng, Aaron Kaat, Cristan Farmer, Audrey Thurm, Catherine A. Burrows, Stephen Kanne, Stelios Georgiades, Amy Esler, Catherine Lord, Nicole Takashashi, Kerri P. Nowell, Elizabeth A. Will Ph.D., Bcba, Jane E. Roberts, Somer L. Bishop

Faculty Publications

No abstract provided.

Incorporating Diversity, Equity, And Inclusion Principles Into Our Metadata, Nicole Lewis, Allie Mccormack, Rachel Jane Wittmann

Faculty Publications

This presentation was given at the Core Forum 2022 in Salt Lake City, Utah.

In early 2021, a group of librarians at two university libraries embarked on a journey to review and update harmful subject headings and other metadata in their catalog, digital library, and finding aids. This session will discuss the background of the project and where the librarians currently stand in the process of remediating these records, including their efforts to create student internships to address problematic language in archival finding aids as well as create a community user advisory group. Special attention will be given to creating …

Personal Digital Archiving, Jeremy Myntti

Faculty Publications

Jeremy Myntti, Associate University Librarian for Metadata and IT at the Brigham Young University Library, presents on ways you can preserve your digital memories.

Watch the presentation here: https://www.youtube.com/watch?v=XNo5W1jRzfs

Development Of A Prediction Model For The Management Of Noncommunicable Diseases Among Older Syrian Refugees Amidst The Covid-19 Pandemic In Lebanon, Stephen J. Mccall, Tanya El Khoury, Noura Salibi, Berthe Abi Zeid, Maria El Haddad, Marwan F. Alawieh, Sawsan Abdulrahim, Monique Chaaya, Hala Ghattas Ph.D., Abla M. Sibai

Faculty Publications

Importance: Older Syrian refugees have a high burden of noncommunicable diseases (NCDs) and economic vulnerability.

Objectives: To develop and internally validate a predictive model to estimate inability to manage NCDs in older Syrian refugees, and to describe barriers to NCD medication adherence.

Design, Setting, and Participants: This nested prognostic cross-sectional study was conducted through telephone surveys between September 2020 and January 2021. All households in Lebanon with Syrian refugees aged 50 years or older and who received humanitarian assistance from a nongovernmental organization were invited to participate. Refugees who self-reported having chronic respiratory disease (CRD), diabetes, history of cardiovascular disease …

Mindfulness-Based Interventions For Survivors Of Lung Cancer And Their Partners: A Systematic Review, Karen Kane Mcdonnell, Otis L. Owens, Fattona Umari

Faculty Publications

Background

Survivors of lung cancer and their partners often have complex unresolved physical, psychosocial, and behavioral needs that can negatively affect the survivors’ and partners’ well-being. This systematic review aimed to (1) examine the content and delivery of mindfulness-based interventions (MBIs) and (2) summarize and synthesize the current evidence for effectiveness of MBIs targeting survivors of lung cancer and/or one selected partner (dyads).

Method

Six databases were searched for interventional studies published in English between 1980 and June 2020 using three terms (lung neoplasms, mindfulness, caregivers). For outcome measures, the interventions focused on behavioral change (meditation, yoga, stretching, breathing), symptom …

Separation Of Track- And Shower-Like Energy Deposits In Protodune-Sp Using A Convolutional Neural Network, A. Abed Abud, B. Abi, R, Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, A. Aduszkiewicz, M. Andreotti, M. Andrews, F. Andrianala, S. Andringa, N. Anfimov, A. Ankowski, M. Antoniassi, M. Antonova, A. Antoshkin, S. Antusch, Roberto Petti, Et. Al.

Faculty Publications

Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagetic …

Tau Neutrinos In The Next Decade: From Gev To Eev, Roshan Mammen Abraham, Jamie Alvarez-Muñiz, Carlos A. Argüelles, Akitaka Ariga, Tomoko Ariga, Adam Aurisano, Dario Autiero, Mary Bishai, Nilay Bostan, Mauricio Bustamante, Austin Cummings, Valentin Decoene, André De Gouvêa, Giovanni De Lellis, Albert De Roeck, Peter B. Denton, Antonia Di Crescenzo, Milind V. Diwan, Yasaman Farzan, Anatoli Fedynitch, Jonathan L. Feng, Laura J. Fields, Alfonso Garcia, Maria Vittoria Garzelli, Julia Gehrlein, Christian Glaser, Katarzyna Grzelak, Steffen Hallmann, Jeremy Hewes, D Indumathi, Ahmed Ismail, Sudip Jana, Yu Seon Jeong, Kevin J. Kelly, Spencer R. Klein, Felix Kling, Thomas Kosc, Umut Kose, D Jason Koskinen, John Krizmanic, Jeff Lazar, Yichen Li, Ivan Martinez-Soler, Irina Mocioiu, Jiwoo Nam, Valentin Niess, Nepomuk Otte, Sameer Patel, Roberto Petti, Et. Al.

Faculty Publications

Tau neutrinos are the least studied particle in the standard model. This whitepaper discusses the current and expected upcoming status of tau neutrino physics with attention to the broad experimental and theoretical landscape spanning long-baseline, beam-dump, collider, and astrophysical experiments. This whitepaper was prepared as a part of the NuTau2021 Workshop.

Metabolome-Wide Associations Of Gestational Weight Gain In Pregnant Women With Overweight And Obesity, Jin Dai, Nansi S. Boghossian, Mark Sarzynski Ph.D., Faha, Facsm, Feng Luo, Xiaoqian Sun, Jian Li, Oliver Fiehn, Jihong Liu Sc.D., Liwei Chen

Faculty Publications

Excessive gestational weight gain (GWG) is associated with adverse pregnancy outcomes. This metabolome-wide association study aimed to identify metabolomic markers for GWG. This longitudinal study included 39 Black and White pregnant women with a prepregnancy body mass index (BMI) of ≥ 25 kg/m². Untargeted metabolomic profiling was performed using fasting plasma samples collected at baseline (mean: 12.1 weeks) and 32 weeks of gestation. The associations of metabolites at each time point and changes between the two time points with GWG were examined by linear and least absolute shrinkage and selection operator (LASSO) regression analyses. Pearson correlations between the …

Can We Picture Equity? Critically Examining Cross-Cultural Short-Term Project Collaborations, Sara Clarke-De Reza, Andrew D. Coppens, Shakuntala Devi Gopal, Sameer Honwad, Madhura Niphadkar, Shraddha Rangnekar

Faculty Publications

This paper explores equity challenges common to short-term cross-cultural research partnerships. We focus on a project-based activity in which U.S. undergraduate students and college faculty taught middle-school students in Goa, India how to make podcasts about complex environmental problems. Project team members conducted a collaborative auto-ethnography focused on questions of power, leadership, collaboration, and equity, and examined exit-interview photo elicitation data to identify the core challenges of ethical and equitable short-term cross-cultural research and programming. Our use of photographs as conversation prompts helped to highlight contradictions and asymmetries along axes of power, cultural imperialism, knower-knowledge, age, race/ethnicity, social class, and …

Avoiding The Appearance Of Virtue: Reactivity To Corporate Social Responsibility Ratings In An Era Of Shareholder Primacy, Ben W. Lewis, W. Chad Carlos

Faculty Publications

We examine why organizations may at times decrease their performance after receiving a positive rating. We argue that in contrast to the prevailing assumption that organizations will strive for favorable ratings to achieve reputational benefits, incompatibility between a positive rating and a dominant institutional logic may cause recognized firms to question the perceived value of maintaining superior performance, thus leading them to strategically reduce their efforts on the rated dimension. Using a difference-in-differences design, we examine how companies responded to being rated as charitable organizations, an evaluation that we argue was generally perceived as incompatible with the dominant logic of …

Direct Measurement Of Stokes–Einstein Diffusion Of Cowpea Mosaic Virus With 19 Μs-Resolved Xpcs, Kacper Switalski, Jingyu Fang, Luxi Li, Miaoqi Chu, Erik Sarnello, Pete Jemian, Tao Li, Qian Wang, Qingteng Zhang

Faculty Publications

Brownian motion of Cowpea mosaic virus (CPMV) in water was measured using small-angle X-ray photon correlation spectroscopy (SA-XPCS) at 19.2 mu s time resolution. It was found that the decorrelation time tau(Q) = 1/DQ(2) up to Q = 0.091 nm(-1). The hydrodynamic radius R-H determined from XPCS using Stokes-Einstein diffusion D = kT/(6 pi eta R-H) is 43% larger than the geometric radius R-0 determined from SAXS in the 0.007 M K3PO4 buffer solution, whereas it is 80% larger for CPMV in 0.5 M NaCl and 104% larger in 0.5 M (NH4)(2)SO4, a possible effect of aggregation as well as …