Digital Commons Network^™

Thriving In The Cold: Glacial Expansion And Post-Glacial Contraction Of A Temperate Terrestrial Salamander (Plethodon Serratus), Catherine E. Newman, Christopher C. Austin

Faculty Publications

© 2015 Newman, Austin. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The dynamic geologic history of the southeastern United States has played a major role in shaping the geographic distributions of amphibians in the region. In the phylogeographic literature, the predominant pattern of distribution shifts through time of temperate species is one of contraction during glacial maxima and persistence in refugia. However, the diverse biology and ecology of amphibian species suggest that a …

Phylogenetics, Divergence Times And Diversification From Three Genomic Partitions In Monocots, Kate L. Hertweck, Michael S. Kinney, Stephanie A. Stuart, Olivier Maurin, Sarah Mathews, Mark W. Chase, Maria A. Gandolfo, J. Chris Pires

Faculty Publications

© 2015 The Authors. Resolution of evolutionary relationships among some monocot orders remains problematic despite the application of various taxon and molecular locus sampling strategies. In this study we sequenced and analysed a fragment of the low-copy, nuclear phytochrome C (PHYC) gene and combined these data with a previous multigene data set (four plastid, one mitochondrial, two nuclear ribosomal loci) to determine if adding this marker improved resolution and support of relationships among major lineages of monocots. Our results indicate the addition of PHYC to the multigene dataset increases support along the backbone of the monocot tree, although relationships among …

Ocean Acidification Research In The 'Post-Genomic' Era: Roadmaps From The Purple Sea Urchin Strongylocentrotus Purpuratus, Tyler G. Evans, Jacqueline L. Padilla-Gamiño, Morgan W. Kelly, Melissa H. Pespeni, Francis Chan, Bruce A. Menge, Brian Gaylord, Tessa M. Hill, Ann D. Russell, Stephen R. Palumbi, Eric Sanford, Gretchen E. Hofmann

Faculty Publications

© 2015 Elsevier Inc. Advances in nucleic acid sequencing technology are removing obstacles that historically prevented use of genomics within ocean change biology. As one of the first marine calcifiers to have its genome sequenced, purple sea urchins (Strongylocentrotus purpuratus) have been the subject of early research exploring genomic responses to ocean acidification, work that points to future experiments and illustrates the value of expanding genomic resources to other marine organisms in this new 'post-genomic' era. This review presents case studies of S. purpuratus demonstrating the ability of genomic experiments to address major knowledge gaps within ocean acidification. Ocean acidification …

An Insight Into The Sialome Of The Lone Star Tick, Ambylomma Americanum, With A Glimpse On Its Time Dependent Gene Expression, Shahid Karim, José M.C. Ribeiro

Faculty Publications

Hard ticks feed for several days or weeks on their hosts. Blood feeding is assisted by tick saliva, which is injected in the host skin regularly, alternating with blood ingestion. Tick saliva contains hundreds or thousands of different peptides and other bioactive compounds that assist feeding by inhibiting their hosts’ blood clotting, platelet aggregation, vasoconstriction, as well as pain and itching. Immunomodulatory and antimicrobial peptides are also found in tick saliva. Molecular characterization of tick salivary compounds, or its sialome (from the Greek sialos = saliva), helps identification of possible antigens that might confer anti-tick immunity, as well as identifying …

Comment On "Fluorotechnology Is Critical To Modern Life: The Fluorocouncil Counterpoint To The Madrid Statement", Ian T. Cousins, Simona A. Balan, Martin Scheringer, Roland Weber, Zhanyun Wang, Arlene Blum, Miriam Diamond, Tony Fletcher, Gretta Goldenman, Christopher Higgins, Avery E. Lindeman, Graham Peaslee

Faculty Publications

No abstract provided.

Prophetic Preaching, Hyveth Williams

Faculty Publications

No abstract provided.

La Validez De Las Leyes Levíticas Alimentarias—Parte I, Jiří Moskala

Faculty Publications

No abstract provided.

Living On The Edge: Settlement Patterns By The Symbiotic Barnacle Xenobalanus Globicipitis On Small Cetaceans, Juan M. Carillo, Robin M. Overstreet, Juan A. Raga, Francisco J. Aznar

Faculty Publications

The highly specialized coronulid barnacle Xenobalanus globicipitis attaches exclusively on cetaceans worldwide, but little is known about the factors that drive the microhabitat patterns on its hosts. We investigate this issue based on data on occurrence, abundance, distribution, orientation, and size of X. globicipitis collected from 242 striped dolphins (Stenella coeruleoalba) that were stranded along the Mediterranean coast of Spain. Barnacles exclusively infested the fins, particularly along the trailing edge. Occurrence, abundance, and density of X. globicipitis were significantly higher, and barnacles were significantly larger, on the caudal fin than on the flippers and dorsal fin. …

Representing Life In The Earth System With Soil Microbial Functional Traits In The Mimics Model, William R. Wieder, A. Stuart Grandy, Cynthia M. Kallenbach, P. G. Taylor, G. B. Bonan

Faculty Publications

Projecting biogeochemical responses to global environmental change requires multi-scaled perspectives that consider organismal diversity, ecosystem processes, and global fluxes. However, microbes, the drivers of soil organic matter decomposition and stabilization, remain notably absent from models used to project carbon (C) cycle–climate feedbacks. We used a microbial trait-based soil C model with two physiologically distinct microbial communities, and evaluate how this model represents soil C storage and response to perturbations. Drawing from the application of functional traits used to model other ecosystems, we incorporate copiotrophic and oligotrophic microbial functional groups in the MIcrobial-MIneral Carbon Stabilization (MIMICS) model; these functional groups are …

Acute Lung Injury Results From Innate Sensing Of Viruses By An Er Stress Pathway, Eike R. Hrincius, Swantje Liedmann, David Finkelstein, Peter Vogel, Shane Gansebom, Amali E. Samarasinghe, Dahui You, Stephania A. Cormier, Jonathan A. Mccullers

Faculty Publications

© 2015 The Authors. Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stress during infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER …

When Nanoparticles Meet Biofilms—Interactions Guiding The Environmental Fate And Accumulation Of Nanoparticles, Kaoru Ikuma, Alan W. Decho, Boris T. Lau

Faculty Publications

Bacteria are essential components of all natural and many engineered systems. The most active fractions of bacteria are now recognized to occur as biofilms, where cells are attached and surrounded by a secreted matrix of “sticky” extracellular polymeric substances. Recent investigations have established that significant accumulation of nanoparticles (NPs) occurs in aquatic biofilms. These studies point to the emerging roles of biofilms for influencing partitioning and possibly transformations of NPs in both natural and engineered systems. While attached biofilms are efficient “sponges” for NPs, efforts to elucidate the fundamental mechanisms guiding interactions between NPs and biofilms have just begun. In …

The Identification Of Novel Protein-Protein Interactions In Liver That Affect Glucagon Receptor Activity, Junfeng Han, Ming Zhang, Sean Froese, Feihan F. Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyu Huang, Weiping Jia, Stéphane Angers, Michael B. Wheeler, Li Wei

Faculty Publications

Glucagon regulates glucose homeostasis by controlling glycogenolysis and gluconeogenesis in the liver. Exaggerated and dysregulated glucagon secretion can exacerbate hyperglycemia contributing to type 2 diabetes (T2D). Thus, it is important to understand how glucagon receptor (GCGR) activity and signaling is controlled in hepatocytes. To better understand this, we sought to identify proteins that interact with the GCGR to affect ligand-dependent receptor activation. A Flag-tagged human GCGR was recombinantly expressed in Chinese hamster ovary (CHO) cells, and GCGR complexes were isolated by affinity purification (AP). Complexes were then analyzed by mass spectrometry (MS), and protein-GCGR interactions were validated by co-immunoprecipitation (Co-IP) …

Resveratrol Induces Brown-Like Adipocyte Formation In White Fat Through Activation Of Amp-Activated Protein Kinase (Ampk) Α1, S. Wang, X. Liang, Q. Yang, X. Fu, C. J. Rogers, M. Zhu, B. D. Rodgers, Q. Jiang, M. V. Dodson, M. Du

Faculty Publications

© 2015 Macmillan Publishers Limited. All rights reserved. Objective: Development of brown-like/beige adipocytes in white adipose tissue (WAT) helps to reduce obesity. Thus we investigated the effects of resveratrol, a dietary polyphenol capable of preventing obesity and related complications in humans and animal models, on brown-like adipocyte formation in inguinal WAT (iWAT). Methods: CD1 female mice (5-month old) were fed a high-fat diet with/without 0.1% resveratrol. In addition, primary stromal vascular cells separated from iWAT were subjected to resveratrol treatment. Markers of brown-like (beige) adipogenesis were measured and the involvement of AMP-activated protein kinase (AMPK) α1 was assessed using conditional …

A Pragmatic, Step-By-Step Guide For Qualitative Methods: Capturing The Disaster And Long-Term Recovery Stories Of Katrina And Rita, Loren D. Marks

Faculty Publications

This paper commences with candid warnings about the difficulties of publishing and funding qualitative research along with a brief discussion regarding why these difficulties persist. The paper then provides a methodological tour of the qualitative portion of the Louisiana Healthy Aging Study (LHAS), a mixed-method study of psychological health, coping, and adjustment during the immediate and longer term aftermath of the 2005 Hurricanes Katrina and Rita. Next, I provide a proven, pragmatic guide to navigate through a qualitative research project from development to completion. A guide for doing solo qualitative (“monk/nun in a cell”) work is provided (Table 1) but …

Nitric Oxide Releases Cl− From Acidic Organelles In Retinal Amacrine Cells, Vijai Krishnan, Evanna Gleason

Faculty Publications

© 2015 Krishnan and Gleason Determining the factors regulating cytosolic Cl− in neurons is fundamental to our understanding of the function of GABA- and glycinergic synapses. This is because the Cl− distribution across the postsynaptic plasma membrane determines the sign and strength of postsynaptic voltage responses. We have previously demonstrated that nitric oxide (NO) releases Cl− into the cytosol from an internal compartment in both retinal amacrine cells and hippocampal neurons. Furthermore, we have shown that the increase in cytosolic Cl− is dependent upon a decrease in cytosolic pH. Here, our goals were to confirm the compartmental nature of the …

Na+/K+-Atpase α1 Mrna Expression In The Gill And Rectal Gland Of The Atlantic Stingray, Dasyatis Sabina, Following Acclimation To Increased Salinity Physiology, Andrew N. Evans, Faith N. Lambert

Faculty Publications

Background: The salt-secreting rectal gland plays a major role in elasmobranch osmoregulation, facilitating ion balance in hyperosmotic environments in a manner analogous to the teleost gill. Several studies have examined the central role of the sodium pump Na⁺/K⁺-ATPase in osmoregulatory tissues of euryhaline elasmobranch species, including regulation of Na⁺/K⁺-ATPase activity and abundance in response to salinity acclimation. However, while the transcriptional regulation of Na⁺/K⁺-ATPase in the teleost gill has been well documented the potential for mRNA regulation to facilitate rectal gland plasticity during salinity acclimation in elasmobranchs …

The Role Of The Language Production System In Shaping Grammars., Dana Mcdaniel Phd, Cecile Mckee, Wayne Cowart Phd, Merrill F. Garrett

Faculty Publications

We argue for an extension of the proposal that grammars are in part shaped by processing systems. Our extension focuses on production, and we use that to explore explanations for certain subject/object asymmetries in extraction structures.

Investigating The Paleoecological Consequences Of Supercontinent Breakup: Sponges Clean Up In The Early Jurassic, Frank Corsetti, Kathleen Ritterbush, David Bottjer, Sarah Greene, Yadira Ibarra, Joyce Yager, A. Joshua West, William Berelson, Silvia Rosas, Thorsten Becker, Naomi Levine, Sean Loyd, Rowan Martindale, Victoria Petryshyn, Nathan Carroll, Elizabeth Petsios, Olivia Piazza, Carlie Pietsch, Jessica Stellmann, Jeffrey Thompson, Kirstin Washington, Dylan Wilmeth

Faculty Publications

The continued release of fossil fuel carbon into the atmosphere today means it is imperative to understand Earth system response to CO2 rise, and the geologic record offers unique opportunities to investigate such behavior. Stomatal and paleosol proxies demonstrate a large change in atmospheric pCO2 across the Triassic-Jurassic (T-J) transition, concomitant with the eruption and emplacement of the Central Atlantic Magmatic Province (CAMP) and the splitting of Pangea. As one of the “big 5” mass extinctions—when the so-called modern fauna was particularly hard hit—we know the biosphere was severely affected during this time, but the details are relatively poorly understood, …

Directional Sound Sensitivity In Utricular Afferents In The Toadfish Opsanus Tau, Karen P. Maruska, Allen F. Mensinger

Faculty Publications

© 2015 Published by The Company of Biologists Ltd. The inner ear of fishes contains three paired otolithic end organs, the saccule, lagena and utricle, which function as biological accelerometers. The saccule is the largest otolith in most fishes and much of our current understanding on auditory function in this diverse group of vertebrates is derived from anatomical and neurophysiological studies on this end organ. In contrast, less is known about how the utricle contributes to auditory functions. In this study, chronically implanted electrodes were used, along with neural telemetry or tethers to record primary afferent responses from the utricular …

Ucp1 Is An Essential Mediator Of The Effects Of Methionine Restriction On Energy Balance But Not Insulin Sensitivity, Desiree Wanders, David H. Burk, Cory C. Cortez, Nancy T. Van, Kirsten P. Stone, Mollye Baker, Tamra Mendoza, Randall L. Mynatt, Thomas W. Gettys

Faculty Publications

© FASEB. Dietary methionine restriction (MR) by 80%increases energy expenditure (EE), reduces adiposity, and improves insulin sensitivity. We propose that the MRinduced increase in EE limits fat deposition by increasing sympathetic nervous system-dependent remodeling of white adipose tissue and increasing uncoupling protein 1 (UCP1) expression in both white and brown adipose tissue. In independent assessments of the role of UCP1 as a mediator of MR's effects on EE and insulin sensitivity, EE did not differ between wild-type (WT) and Ucp1^-/- mice on the control diet, butMR increased EE by 31%and reduced adiposity by 25% in WT mice. In contrast, …

Disease And Dowry: Community Context, Gender, And Adult Health In India, Samuel Stroope

Faculty Publications

Despite growing research on health and residential contexts, relatively little is understood about gendered contexts that are differentially important for women's and men's physical health in low- and middle-income countries. This study advances the prior knowledge by examining whether the local frequency of a salient and gendered practice in India-dowry-is associated with gender differences in physical health (acute illness, illness length, and chronic illness). Analyses are conducted using multilevel logistic and negative binomial regression models and national data on men and women across India (N = 102,763). Results show that as dowry frequency increases in communities, not only do women …

Meat Intake And Insulin Resistance In Women Without Type 2 Diabetes, Larry A. Tucker, James D. Lecheminant, Bruce W. Bailey

Faculty Publications

Purpose. To examine the relationship between meat intake and insulin resistance (IR) in 292 nondiabetic women. Methods. IR was evaluated using the homeostasis model assessment (HOMA). Diet was assessed via 7-day weighed food records. Servings of very lean meat (VLM) and regular meat (meat) were indexed using the ADA Exchange Lists Program. Physical activity was assessed using accelerometers and body fat was measured using the Bod Pod. Results. Meat intake was directly related to HOMA (F = 7.4; P = 0.007). Women with moderate or high meat intakes had significantly higher HOMA levels than their counterparts. Adjusting for body fat …

Ccl20 Is Elevated During Obesity And Differentially Regulated By Nf-Κb Subunits In Pancreatic Β-Cells, Susan J. Burke, Michael D. Karlstad, Kellie M. Regal, Tim E. Sparer, Danhong Lu, Carrie M. Elks, Ryan W. Grant, Jacqueline M. Stephens, David H. Burk, J. Jason Collier

Faculty Publications

© 2015 Elsevier B.V. Enhanced leukocytic infiltration into pancreatic islets contributes to inflammation-based diminutions in functional β-cell mass. Insulitis (aka islet inflammation), which can be present in both T1DM and T2DM, is one factor influencing pancreatic β-cell death and dysfunction. IL-1β, an inflammatory mediator in both T1DM and T2DM, acutely (within 1. h) induced expression of the CCL20 gene in rat and human islets and clonal β-cell lines. Transcriptional induction of CCL20 required the p65 subunit of NF-κB to replace the p50 subunit at two functional κB sites within the CCL20 proximal gene promoter. The NF-κB p50 subunit prevents CCL20 …

An Innovative Approach To Decreasing Concussions In Adolescent Female Soccer Athletes: 2370 Board #117 May 29, 9, A. Lynn Millar, Brent A. Harper, Jared Casazza, Cameron Lephew, Meredith Moore, Timothy Schmidt

Faculty Publications

Concussion is a public health issue, fundamental to health promotion and injury prevention. Concussions are prevalent in adolescent athletic competition, in high-collision and non-collision sports. A history of previous concussion increases risk by a factor of three, female gender increases it 1.5 to 2.5 times, and female middle-school soccer players have 22.9 times increased risk during games. Non-collision concussions (indirect) may be primed by altered movement patterns from previous injuries, disruption of cervical proprioception, or musculoskeletal pain. Assessment of dynamic balance and functional movement allows identification of poor movement patterns or control.

PURPOSE: To assess a preventative movement-based warm-up routine …

An Extract Of Artemisia Dracunculus L. Stimulates Insulin Secretion From Β Cells, Activates Ampk And Suppresses Inflammation, Sita Aggarwal, Giri Shailendra, David M. Ribnicky, David Burk, Namrata Karki, M. S. Qingxia Wang

Faculty Publications

© 2015 Elsevier Ireland Ltd. All rights reserved. Ethnopharmacological relevance Artemisia dracunculus L. (Russian tarragon) is a perennial herb belonging to the family Compositae and has a history of medicinal use in humans, particularly for treatment of diabetes. Aim of the study: In this study a defined plant extract from A. dracunculus L. (termed PMI-5011) is used to improve beta(β) cells function and maintain β cell number in pancreatic islets as an alternative drug approach for successful treatment of diabetes. Materials and methods Mouse and human pancreatic beta cells were treated with defined plant extract of A. dracunculus L. (PMI-5011) …

Inhibition Of Cytochrome P450 2b4 By Environmentally Persistent Free Radical-Containing Particulate Matter, James R. Reed, Albert Leo N.Dela Cruz, Slawo M. Lomnicki, Wayne L. Backes

Faculty Publications

Combustion processes generate particulate matter (PM) that can affect human health. The presence of redox-active metals and aromatic hydrocarbons in the post-combustion regions results in the formation of air-stable, environmentally persistent free radicals (EPFRs) on entrained particles. Exposure to EPFRs has been shown to negatively influence pulmonary and cardiovascular functions. Cytochromes P450 (P450/CYP) are endoplasmic reticulum resident proteins that are responsible for the metabolism of foreign compounds. Previously, it was shown that model EPFRs, generated by exposure of silica containing 5% copper oxide (CuO-Si) to either dicholorobenzene (DCB230) or 2-monochlorophenol (MCP230) at ≥ 230°C, inhibited six forms of P450 in …

Biological Evidence Supports An Early And Complex Emergence Of The Isthmus Of Panama, Christine D. Bacona, Daniele Silvestro, Carlos Jaramillo, Brian Tilston Smith, Prosanta Chakrabarty, Alexandre Antonelli

Faculty Publications

The linking of North and South America by the Isthmus of Panama had major impacts on global climate, oceanic and atmospheric currents, and biodiversity, yet the timing of this critical event remains contentious. The Isthmus is traditionally understood to have fully closed by ca. 3.5 million years ago (Ma), and this date has been used as a benchmark for oceanographic, climatic, and evolutionary research, but recent evidence suggests a more complex geological formation. Here, we analyze both molecular and fossil data to evaluate the tempo of biotic exchange across the Americas in light of geological evidence. We demonstrate significant waves …

Self-Assembly Dynamics For The Transition Of A Globular Aggregate To A Fibril Network Of Lysozyme Proteins Via A Coarse-Grained Monte Carlo Simulation, Ras B. Pandey, Barry L. Farmer, Bernard S. Gerstman

Faculty Publications

The self-organizing dynamics of lysozymes (an amyloid protein with 148 residues) with different numbers of protein chains, Nc = 1,5,10, and 15(concentration 0.004 – 0.063) is studied by a coarse-grained Monte Carlo simulation with knowledge-based residue-residue interactions. The dynamics of an isolated lysozyme (Nc = 1) is ultra-slow (quasi-static) at low temperatures and becomes diffusive asymptotically on raising the temperature. In contrast, the presence of interacting proteins leads to concentration induced protein diffusion at low temperatures and concentration-tempering sub-diffusion at high temperatures. Variation of the radius of gyration of the protein with temperature shows a …

Competition And Habitat Quality Influence Age And Sex Distribution In Wintering Rusty Blackbirds, Claudia Mettke-Hofmann, Paul B. Hamel, Gerhard Hoffman, Theodore J. Zenzal Jr., Anne Pellegrini, Jennifer Malpass, Megan Garfinkel, Nathan Schiff, Russell Greenberg

Faculty Publications

Bird habitat quality is often inferred from species abundance measures during the breeding and non-breeding season and used for conservation management decisions. However, during the non-breeding season age and sex classes often occupy different habitats which suggest a need for more habitat-specific data. Rusty Blackbird (Euphagus carolinus) is a forested wetland specialist wintering in bottomland hardwood forests in the south-eastern U. S. and belongs to the most steeply declining songbirds in the U.S. Little information is available to support priority birds such as the Rusty Blackbird wintering in this threatened habitat. We assessed age and sex distribution and …

The Obsessional Information Professional: Four Decades Of Versifying Libraries And Librarians, Richard Hacken

Faculty Publications

Occasional poetry and parodies written by Richard Hacken from the 1980s to 2016 in honor of libraries and librarians:

In chronological order from the Harold B. Lee Library: John Taylor; Janet O. Francis; Gerald K. Dick; Sterling Albrecht; Roy Daniel; Keith Stirling; Don Howard; Haybron Adams; Christina Almond; Marvin Wiggins; Gary Gillum; Susan Fales; Randy Olsen; Richard Jensen; Karen Griggs; Deb Hatch; Julene Butler; Mark Grover; Tom Wright; Marianne Siegmund

Occasions: retirements, HBLL Christmas parties, introductions, farewells, BYU Library School reunion

From Northwestern University: Jeff Garrett. From Harvard University: Charles Fineman. From University of Wisconsin: Barbara Walden. From University of …