Digital Commons Network^™

Acetylation Of Androgen Receptor By Ard1 Promotes Dissociation From Hsp90 Complex And Prostate Tumorigenesis, John S. Depaolo, Zehua Wang, Jianhui Guo, Guanyi Zhang, Chiping Qian, Haitao Zhang, Jovanny Zabaleta, Wanguo Liu

Faculty Publications

Prostate cancer is an androgen receptor (AR)-driven disease and post-translational modification of AR is critical for AR activation. We previously reported that Arrestdefective protein 1 (ARD1) is an oncoprotein in prostate cancer. It acetylates and activates AR to promote prostate tumorigenesis. However, the ARD1-targeted residue within AR and the mechanisms of the acetylation event in prostate tumorigenesis remained unknown. In this study, we show that ARD1 acetylates AR at lysine 618 (K618) in vitro and in vivo. An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, …

Rearrangement And Evolution Of Mitochondrial Genomes In Parrots, Jessica R. Eberhard, Timothy F. Wright

Faculty Publications

© 2015 Elsevier Inc. Mitochondrial genome rearrangements that result in control region duplication have been described for a variety of birds, but the mechanisms leading to their appearance and maintenance remain unclear, and their effect on sequence evolution has not been explored. A recent survey of mitochondrial genomes in the Psittaciformes (parrots) found that control region duplications have arisen independently at least six times across the order. We analyzed complete mitochondrial genome sequences from 20 parrot species, including representatives of each lineage with control region duplications, to document the gene order changes and to examine effects of genome rearrangements on …

Cryopreservation In Fish: Current Status And Pathways To Quality Assurance And Quality Control In Repository Development, Leticia Torres, E. Hu, Terrence R. Tiersch

Faculty Publications

Cryopreservation in aquatic species in general has been constrained to research activities for more than 60 years. Although the need for application and commercialisation pathways has become clear, the lack of comprehensive quality assurance and quality control programs has impeded the progress of the field, delaying the establishment of germplasm repositories and commercial-scale applications. In this review we focus on the opportunities for standardisation in the practices involved in the four main stages of the cryopreservation process: (1) source, housing and conditioning of fish; (2) sample collection and preparation; (3) freezing and cryogenic storage of samples; and (4) egg collection …

Glufosinate Rate And Timing For Control Of Glyphosate-Resistant Rhizomatous Johnsongrass (Sorghum Halepense) In Glufosinate-Resistant Soybean, Randall L. Landry, Daniel O. Stephenson, Brandi C. Woolam

Faculty Publications

Field studies were conducted over a three-year period (2011, 2012, and 2013) in Louisiana to evaluate the effect of glufosinate rate and timing on glyphosate-resistant (GR) rhizomatous johnsongrass control in glufosinate-resistant soybean. Treatments included glufosinate (0.5, 0.6, or 0.7 kg ai ha-1) applied alone POST1 (46 cm tall johnsongrass) and sequentially 3 (POST2) or 4 (POST3) wk after POST1 at 0.5 or 0.6 kg ha-1. Glufosinate (0.7 kg ha-1) applied POST1 controlled johnsongrass 77% at soybean harvest. Averaged across sequential application rate, delaying the sequential application from POST2 to POST3 increased control from 65 to 78% at harvest. Increasing sequential …

Clinically Relevant Behavioral Endpoints In A Recurrent Nitroglycerin Migraine Model In Rats, Kenneth J. Sufka, Stephanie M. Staszko, Ainslee P. Johnson, Morgan E. Davis, Rachel E. Davis, Todd A. Smitherman

Faculty Publications

BACKGROUND: This research sought to further validate the rat nitroglycerin (NTG) migraine model by comparing the effects of single versus recurrent NTG episodes on behavioral endpoints that mirror ICHD-3 diagnostic criteria for migraine, and to determine if the altered behavioral endpoints are reduced after administration of sumatriptan. METHODS: Separate cohorts of rats were administered NTG (10 mg/kg/2 ml) or saline (Experiment 1: single injection; Experiment 2: repeated injections; Experiment 3: repeated injections with sumatriptan [0.0, 0.3 and 1.0 mg/kg/ml] rescue. Behavioral endpoints were assessed 2 h after final NTG administration and included time in light/dark chambers for photophobia and activity, …

The Social Relations Of Consumption: Corporate Law And The Meaning Of Consumer Culture, David Yosifon

Faculty Publications

A mature assessment of the society we are making for ourselves, and the legacy we are leaving to the future, must come to terms with consumer culture. Theoretical discourse, as well as common experience, betray persistent ambiguity about what consumerism means to and says about us. In this Article, I argue that this ambiguity can in part be explained by examining the social relations of consumption in contemporary society. These involve, crucially, the relationship between producer and consumer that is dictated by corporate governance law, and embodied in the decision-making dynamics of the directors who command corporate operations. The enigmatic …

Wealth Inequality And Family Businesses, Benjamin Means

Faculty Publications

Wealth inequality endangers democratic values and calls for a public response. This Article contends that family businesses merit special scrutiny because they control vast amounts of private wealth and combine two of society's most important economic institutions: family and business. Accordingly, family businesses implicate concerns regarding both inherited wealth and the concentration of economic power made possible by the corporate form.

Despite their economic significance, little has been done to investigate whether family businesses contribute to wealth inequality. This Article offers the first legal, and one of the only academic, treatments of the topic and shows that family businesses play …

Addressing Rural Blight: Lessons From West Virginia And Wv Leap, Ann M. Eisenberg

Faculty Publications

No abstract provided.

The Politics Of Fresh Water: Setting The Stage, Tamar Mayer, Catherine M. Ashcraft

Faculty Publications

This chapter identifies insights into the politics of fresh water and introduces the contributions to the book The Politics of Fresh Water: Access, conflict and identity. First, the social, physical, and ecological components of water systems are interconnected, forming a hydro-social system. Second, instead of being inevitable, freshwater crisis is a socially constructed experience, a lived phenomenon. Water scarcity is not simply the result of what nature has to offer but always involves power relations and political decisions. The water crisis is not only about who is granted access to safe, clean water (when, where, and why), but also about …

Predicting Dna Methylation State Of Cpg Dinucleotide Using Genome Topological Features And Deep Networks, Yiheng Wang, Tong Liu, Dong Xu, Huidong Shi, Chaoyang Zhang, Yin-Yuan Mo, Zheng Wang

Faculty Publications

The hypo- or hyper-methylation of the human genome is one of the epigenetic features of leukemia. However, experimental approaches have only determined the methylation state of a small portion of the human genome. We developed deep learning based (stacked denoising autoencoders, or SdAs) software named "DeepMethyl" to predict the methylation state of DNA CpG dinucleotides using features inferred from three-dimensional genome topology (based on Hi-C) and DNA sequence patterns. We used the experimental data from immortalised myelogenous leukemia (K562) and healthy lymphoblastoid (GM12878) cell lines to train the learning models and assess prediction performance. We have tested various SdA architectures …

Do Vertebral Chemical Signatures Distinguish Juvenile Blacktip Shark (Carcharhinus Limbatus) Nursery Regions In The Northern Gulf Of Mexico?, Justin P. Lewis, William F. Patterson Iii, John K. Carlson, Katherine Mclachlin

Faculty Publications

Identifying and protecting shark nurseries is a common management strategy used to help rebuild overfished stocks, yet we know little about connectivity between juvenile and adult populations. By analysing trace metals incorporated into vertebral cartilage, it may be possible to infer natal origin based on nursery-specific chemical signatures. To assess the efficacy of this approach, we collected juvenile blacktip sharks (Carcharhinus limbatus; n = 93) from four regions in the Gulf of Mexico in 2012 and 2013 and analysed their vertebral centra with laser ablation-inductively coupled plasma-mass spectrometry. We observed significant regional differences in six element : Ca …

#Iftheygunnedmedown: Postmodern Media Criticism In A Post-Racial World, Christopher P. Campbell

Faculty Publications

After the 2014 fatal shooting of Michael Brown, an unarmed 18-year-old African American man, by a White police officer in Ferguson, Missouri, some news organizations included in their immediate coverage a photo of Brown taken from his Facebook page. In a now iconic image, Brown stands in a Nike tank top, unsmiling, and flashing a peace sign (misidentified by some news organizations as a gang sign). Later, less incendiary photos from Brown’s Facebook page surfaced. Within a few days of Brown’s death, the hashtag #IfTheyGunnedMeDown appeared on social media. Young African Americans posted two photos of themselves, representing positive and …

Animism Among Western Buddhists, Daniel S. Capper

Faculty Publications

Myriad instances of animist phenomena abound in the Buddhist world, but due to the outdated concepts of thinkers such as Edward Tylor, James George Frazer, and Melford Spiro, commonly scholars perceive this animism merely as the work of local religions, not as deriving from Buddhism itself. However, when one follows a number of contemporary scholars and employs a new, relational concept of animism that is based on respectful recognition of nonhuman personhoods, a different picture emerges. The works of Western Buddhists such as Stephanie Kaza, Philip Kapleau Roshi, and Gary Snyder express powerful senses of relational animism that arise specifically …

The Maternal Personhood Of Cattle And Plants At A Hindu Center In The United States, Daniel S. Capper

Faculty Publications

Religious experiences with sacred nonhuman natural beings considered to be “persons” remain only vaguely understood. This essay provides a measure of clarification by engendering a dialogue between psychoanalytic self psychology on one side and, on the other, religious experiences of cattle and Tulsi plants as holy mothers at a Hindu cattle sanctuary in the United States. Ethnographic data from the Hindu center uncover experiences of sacred maternal natural beings that are tensive, liminal, and colored with affective themes of nurturance, respect, and intimacy, much like psychoanalytic maternal selfobjects. Devotees protect cattle and ritually venerate plants because these actions facilitate a …

Groundhog Oracles And Their Forebears, Daniel S. Capper

Faculty Publications

Groundhog Day animal weather forecasting ceremonies continue to proliferate around the United States despite a lack of public confidence in the oracles. This essay probes religio-historical and original ethnographic perspectives to offer a psychological argument for why these ceremonies exist. Employing Paul Shepard’s notion of a felt loss of sacred, intimate relationships with nonhuman nature, as well as Peter Homans’ concept of the monument that enables mourning, this essay argues that groundhog oracles serve as monuments that allow humans experientially to attempt to heal lost sacred relationships with animals like weather forecasting bears, hedgehogs, and badgers

Sexbots; An Obloquy, Thomas Simmons

Faculty Publications

Sexbots may displace humans in the sex trade (or on a wider scale) sometime between the 2020s and the 2050s. Although some perquisites may derive from the proliferation of sexbots (lower levels of sexually transmitted diseases, for example), significant social harms can also be predicted. In anticipation of those harms, lawmakers may endorse targeted regulation or outright bans. The uncertain limits of Lawrence v. Texas and its progeny of sex-toy decisions will present vague constitutional shoals to these aims. The legislating-of-sexbots crusade will also make for strange bedfellows, politically speaking, as social conservatives aiming to maintain traditional values ally with …

Serious Games: An Evaluation Framework And Case Study, David W. Wilson, Jeff Jenkins, Nathan Twyman, Matthew Jensen, Joe Valacich, Norah Dunbar, Scott Wilson, Claude Miller, Bradley Adame, Yu-Hao Lee, Judee Burgoon, Jay F. Nunamaker

Faculty Publications

Serious games show promise as an effective training method, but such games are complex and few guidelines exist for their effective evaluation. We draw on the design science literature to develop a serious game evaluation framework that emphasizes grounding evaluation in each of four key areas— theoretical, technical, empirical, and external. We further recommend that serious game developers assume an iterative, adaptive approach to grounding an evaluation effort in these four areas, emphasizing some areas more than others at different stages of the development cycle. We illustrate our framework using a case study of a large-scale serious game development project. …

Application Of Expectancy Violations Theory To Communication With And Judgments About Embodied Agents During A Decision-Making Task, Judee K. Burgoon, Joseph Bonito, Paul Benjamin Lowry, Sean Humphreys, Gregory D. Moody, James Gaskin, Justin Giboney

Faculty Publications

Because users treat embodied agents (EAs) as social actors, users hold expectations about human-to-EA communication (HtEAC) similar to those in human-to-human communication. This study extends Expectancy Violations Theory (EVT) to examine how different forms of interfaces that confirm or violate user expectations affect the communication process, social judgments, ability to influence, and accuracy of recall associated with HtEAC. Positive violations of expectancy are acts or characteristics of the EA that are unexpected but evaluated favorably by the human partner. Results suggest that when the EA deviates from expectations, effects on the HtEAC process and related outcomes can be more pronounced. …

Free Exercise By Moonlight, Marc O. Degirolami

Faculty Publications

How is the current condition of religious free exercise, and religious accommodation in specific, best understood? What is the relationship of the two most important free exercise cases of the past half-century, Employment Division v. Smith and Hosanna-Tabor Evangelical Lutheran Church and School v. EEOC? This essay explores four possible answers to these questions.

1. Smith and Hosanna-Tabor are the twin suns of religious accommodation under the Constitution. They are distinctively powerful approaches.

2. Hosanna-Tabor’s approach to constitutional free exercise is now more powerful than Smith’s. Smith has been eclipsed.

3. Hosanna-Tabor has shown itself to be feeble. It has …

Virtue, Freedom, And The First Amendment, Marc O. Degirolami

Faculty Publications

The modern First Amendment embodies the idea of freedom as a fundamental good of contemporary American society. The First Amendment protects and promotes everybody’s freedom of thought, belief, speech, and religious exercise as basic goods—as given ends of American political and moral life. It does not protect these freedoms for the sake of promoting any particular vision of the virtuous society. It is neutral on that score, setting limits only in those rare cases when the exercise of a First Amendment freedom exacts an intolerable social cost.

Something like this collection of views constitutes the conventional account of the First …

Police Suspects, Kate Levine

Faculty Publications

Recent attention to police brutality has brought to the fore how police, when they become the subject of criminal investigations, are given special procedural protections not available to any other criminal suspect. Prosecutors’ special treatment of police suspects, particularly their perceived use of grand juries to exculpate accused officers, has received the lion’s share of scholarly and media attention. But police suspects also benefit from formal affirmative rights that protect them from interrogation by other officers. Police, in most jurisdictions, have a special shield against interrogation known as the Law Enforcement Officers’ Bill of Rights (LEOBORs). These statutes and negotiated …

Data For Henson Et Al. 2016, Shandelle Henson, James Hayward, J Cushing, Gordon Atkins, Sumiko Weir, Ashley Reichert, Wayanne Watson, Wadenerson Saint Martin, Amanda Sandler

Faculty Publications

These data are archived for the paper "Adaptation to short-term ENSO fluctuations may provide tipping points for populations subjected to long-term climate change" by Henson et al., submitted. Additional files: Supplementary Figure 1 | Sample plots on Violet Point, Protection Island National Wildlife Refuge, Washington, USA. The larger colony extends throughout much of the spit.

Gras-Fed Americans: Sick Of Lax Regulation Of Food Additives, Martha Dragich

Faculty Publications

Americans are “GRAS-fed” because of a “loophole” in the strict regime Congress provided for the regulation of food additives. Additives - and food products containing them - are exempt from this strict regime if they are accorded GRAS (Generally Recognized as Safe) status. The guidelines Congress provided for achieving that status by scientific evidence of safety are no longer observed. Most additives are determined by the producer alone to be GRAS. At the same time, Americans’ consumption of highly processed foods continues to rise, giving rise to long-term health problems that are increasingly tied to diet. The average American’s diet …

Late Fremont Cultural Identities And Borderland Processes, Michael T. Searcy, Richard K. Talbot

Faculty Publications

he spread of maize farming across the American Southwest reached its northernmost extent west of the Rockies by the first or second centuries ad (James Allison, personal communication, 2014; Allison 2014), in the area encompassing the Colorado Plateau north of the Colorado River and the eastern portion of the Great Basin. he practitioners of farming in this area, the Fremont, generally resemble other Southwest farmers in material culture, social structure, settlement, and land use. hey are markedly different from contemporaneous hunter- gatherers to the west, north, and east in these same characteristics and in general economic strategy. Changing paradigms have …

Joseph Smith And His Apostasy And Restoration Culture, Trevan Hatch

Faculty Publications

Jesus Christ told Joseph Smith Jr. in the spring of 1820 that he must not join any church because they were all wrong: "all their creeds are an abomination in my sight .... Their hearts are far from me [and] they teach for doctrines the commandments of men, having a form of Godliness but they deny the power thereo£" This commandment prohibiting Joseph from joining a church due to corruption will be discussed at length in this chapter.

Development Of Distributed Research Center For Analysis Of Regional Climatic And Environmental Changes, E. Gordov, Alexander I. Shiklomanov, I. Okladnikov, Alexander A. Prusevich, A. Titov

Faculty Publications

We present an approach and first results of a collaborative project being carried out by a joint team of researchers from the Institute of Monitoring of Climatic and Ecological Systems, Russia and Earth Systems Research Center UNH, USA. Its main objective is development of a hardware and software platform prototype of a Distributed Research Center (DRC) for monitoring and projecting of regional climatic and environmental changes in the Northern extratropical areas. The DRC should provide the specialists working in climate related sciences and decision-makers with accurate and detailed climatic characteristics for the selected area and reliable and affordable tools for …

Sensation, Intuition, Space, And Time In Hegel’S Philosophy Of Subjective Spirit, Willem A. Devries

Faculty Publications

The subject of space, time, sensation, and intuition in Hegel is complicated, more so in Hegel than in Kant, and for good reason. Hegel rejected Kant’s Transcendental Idealism; besides the subjective reality Kant attributed to space and time, Hegel also attributed to them a truly objective reality. According to Hegel, space and time qualify finite things as they really are. Moreover, I shall argue, space and time, in Hegel’s view, have two different modes of subjective presence. We can illuminate these distinctive modes of subjective presence by comparing Hegel’s with Wilfrid Sellars’ strikingly similar arguments against Transcendental Idealism.

Persistent Threats To Commercial Speech, Jonathan H. Adler

Faculty Publications

The current Supreme Court is very protective of speech, including commercial speech. Threats to commercial speech persist nonetheless. This article briefly examines two: the use of commercial speech restrictions as a form of rent-seeking, and compelled commercial speech. Regulation of commercial speech is sometimes used to protect established corporate interests from competitors who are less able to bear the costs of regulation, with consequences that extend beyond the economic marketplace. In the case of commercial speech, courts have also been unduly deferential to claims of a consumer “right to know” as a basis for mandated labeling and disclosure. Greater and …

Compelled Commercial Speech And The Consumer "Right To Know", Jonathan H. Adler

Faculty Publications

Compelled commercial speech, including mandatory labeling and the disclosure of factually true information, should not be seen as a separate category of speech under the First Amendment. Rather, compelled commercial speech should be understood as a type of commercial speech and be subject to the same level of protection as commercial speech generally. Accordingly, commercial speech compulsions, such as mandatory disclosures and labeling requirements, must be supported by a substantial government interest under the Central Hudson framework. The assertion of a consumer “right to know” does not constitute such an interest and cannot, by itself, justify compelled commercial speech within …

Adolescent Summer Camp Volunteers’Attitudes Toward Peers With Disabilities, Megan Fort, Neil Lundberg, Ramon Zabriskie, Dennis Eggett, Mary Anne Prater, Keith Barney

Faculty Publications

This study explored themalleability of adolescent attitudes toward their peers with disabilities after volunteering in a summer day-camp. The Contact with Disabled Persons Scale (CDP) and the Multi-Dimensional Attitude Scale (MAS) were used to collect data in order to determine the association between volunteering in a recreation-based summer day camp and adolescent attitudes toward disability. After a covariateadjusted regression analysis, contact with individuals with disabilities was found to significantly predict change in attitudes toward disability. Dyadic interviews were held after camp participation to provide additional sources of data with potential for deeper understanding of the camp experience for volunteers. The …