Digital Commons Network^™

The Association Between Gastro-Oesophageal Reflux Disease And Subsequent Rheumatoid Arthritis Occurrence: A Nested Case–Control Study From Taiwan, Herng-Ching Lin, Sudha Xirasagar, Cha-Ze Lee, Chung-Chien Huang, Chao-Hung Chen

Faculty Publications

Objective Gastro-oesophageal reflux disease (GORD) is a common comorbidity among patients with rheumatoid arthritis (RA). While GORD has been attributed to the antirheumatic medications, no studies of human cohorts have investigated a link between GORD and RA. This study investigates whether GORD is associated with a subsequent RA diagnosis over a 5-year follow-up using a population-based dataset.

Setting Taiwan

Participants We used data from the Taiwan Longitudinal Health Insurance Database. The study group consisted of 13 645 patients with an ambulatory claim showing a GORD diagnosis. We used propensity score matching to select 13 645 comparison patients (one per study …

Multiple Species Of Cuckoos Are Superior Predictors Of Bird Species Richness In Asia, Anders Pape Møller, Federico Morelli, Yanina Benedetti, Timothy Mousseau, Tongping Su, Bo Zhou, Piotr Tryjanowski, Wei Liang

Faculty Publications

The abundance and the presence of common cuckoos Cuculus canorus have been shown to predict species richness of birds across Europe, while there are no such analyses available for other continents where species richness of parasitic cuckoos is larger. Here, we tested whether species richness of birds increased with the number of cuckoo species in two study areas in China and one in Japan. We also tested whether species richness of birds can be predicted by the number of cuckoo individuals. Furthermore, we compared the strength of association between overall bird species richness and species richness of cuckoos, Paridae, Corvidae, …

An Undergraduate Laboratory Manual For Analyzing A Crispr Mutant With A Predicted Role In Regeneration, Susan Walsh, Ashley Becker, Paxton S. Sickler, Damian G. Clarke, Erin Jimenez

Faculty Publications

Exposing students to undergraduate research has reportedly improved students’ development of knowledge and skills in the laboratory, self-efficacy, satisfaction with their research, retention, and perseverance when faced with obstacles. Furthermore, utilizing authentic course-based undergraduate research experiences (CUREs) includes all students enrolled in the class, giving those who may not otherwise have access to an independent undergraduate research project an opportunity to engage in the scientific process in context of an original, unanswered question. In the fall of 2016, second semester introductory biology students conducted a semester-long research project on the transcription factor Lin28a to determine the effect of Lin28a on …

Reaching In Clutter With Whole-Arm Tactile Sensing, Advait Jain, Marc D. Killpack, Aaron Edsinger, Charles Kemp

Faculty Publications

Clutter creates challenges for robot manipulation, including a lack of non-contact trajectories and reduced visibility for line-of-sight sensors. We demonstrate that robots can use whole-arm tactile sensing to perceive clutter and maneuver within it, while keeping contact forces low. We first present our approach to manipulation, which emphasizes the benefits of making contact across the entire manipulator and assumes the manipulator has low-stiffness actuation and tactile sensing across its entire surface. We then present a novel controller that exploits these assumptions. The controller only requires haptic sensing, handles multiple contacts, and does not need an explicit model of the environment …

Integrating The Effects Of Salinity On The Physiology Of The Eastern Oyster, Crassostrea Virginica, In The Northern Gulf Of Mexico Through A Dynamic Energy Budget Model, Romain Lavaud, Megan K. La Peyre, Sandra M. Casas, Cédric Bacher, Jérôme F. La Peyre

Faculty Publications

© 2017 We present a Dynamic Energy Budget (DEB) model for the eastern oyster, Crassostrea virginica, which enables the inclusion of salinity as a third environmental variable, on top of the standard foodr and temperature variables. Salinity changes have various effects on the physiology of oysters, potentially altering filtration and respiration rates, and ultimately impacting growth, reproduction and mortality. We tested different hypotheses as to how to include these effects in a DEB model for C. virginica. Specifically, we tested two potential mechanisms to explain changes in oyster shell growth (cm), tissue dry weight (g) and gonad dry weight (g) …

A Role For The Cystic Fibrosis Transmembrane Conductance Regulator In The Nitric Oxide-Dependent Release Of Cl – From Acidic Organelles In Amacrine Cells, Vijai Krishnan, J. Wesley Maddox, Tyler Rodriguez, Evanna Gleason

Faculty Publications

© 2017 the American Physiological Society. γ-Amino butyric acid (GABA) and glycine typically mediate synaptic inhibition because their ligandgated ion channels support the influx of Cl – . However, the electrochemical gradient for Cl – across the postsynaptic plasma membrane determines the voltage response of the postsynaptic cell. Typically, low cytosolic Cl – levels support inhibition, whereas higher levels of cytosolic Cl – can suppress inhibition or promote depolarization. We previously reported that nitric oxide (NO) releases Cl – from acidic organelles and transiently elevates cytosolic Cl – , making the response to GABA and glycine excitatory. In this study, …

Transcription-Driven Dna Methylation Setting On The Mouse Peg3 Locus, Corey L. Bretz, Joomyeong Kim

Faculty Publications

© 2017 Taylor & Francis Group, LLC. The imprinting of the mouse Peg3 domain is controlled through the Peg3-DMR, which obtains its maternal-specific DNA methylation during oogenesis. In the current study, we deleted an oocyte-specific alternative promoter, termed U1, which is localized 20 kb upstream of the Peg3-DMR. Deletion of this alternative promoter resulted in complete removal of the maternal-specific DNA methylation on the Peg3-DMR. Consequently, the imprinted genes in the Peg3 domain become biallelic in the mutants with maternal transmission of the deletion. Expression levels of the imprinted genes were also affected in the mutants: 2-fold upregulation of Peg3 …

Stones And Bones: Catholic Responses To The 1812 Collapse Of The Mission Church Of Capistrano, Karin Vélez

Faculty Publications

This essay delves into the 1812 collapse of the Great Stone Church at California’s Mission of San Juan Capistrano and its aftermath to consider how early modern Catholics in the greater Iberian world approached the material remains of ruined churches that contained human victims. Questions explored include how Franciscan missionaries reported and reacted to the calamity, why the casualties were disproportionately Indian and female, and what survivors did with the physical remnants of broken churches. Churches that collapsed on worshippers in Arequipa, Cuzco, Lima and Lisbon prior to 1812 are mustered for comparison. Overall, a pattern emerges of Catholics separating …

Classifying And Predicting Occupational Incident Severity, Fatemeh Davoudi Kakhki, Steven Freeman, Gretchen Mosher

Faculty Publications

The focus of the study is to build a predictive model and assess its performance in classifying the financial severity of occupational injuries in agribusiness bulk storage facilities (i.e. grain elevators). The data specifically look at food processing and feed milling operations within these facilities. The severity of occupational injuries is determined by the total dollar amount incurred on medical costs, indemnity costs and other expenses in workers’ compensation claims. The data is available from an agribusiness insurance provider in Midwest USA. First, the most important independent variables that affect the total cost of claims are extracted from the original …

Cysteines And N-Glycosylation Sites Conserved Among All Alphaherpesviruses Regulate Membrane Fusion In Herpes Simplex Virus 1 Infection, Paul J.F. Rider, Misagh Naderi, Scott Bergeron, Vladimir N. Chouljenko, Michal Brylinski, Konstantin G. Kousoulas

Faculty Publications

© 2017 American Society for Microbiology. Neurotropism is a defining characteristic of alphaherpesvirus pathogenicity. Glycoprotein K (gK) is a conserved virion glycoprotein of all alphaherpesviruses that is not found in other herpesvirus subfamilies. The extracellular amino terminus of gK has been shown to be important to the ability of the prototypic alphaherpesvirus herpes simplex virus 1 (HSV-1) to enter neurons via axonal termini. Here, we determined the role of the two conserved N-linked glycosylation (N48 and N58) sites of gK in virus-induced cell fusion and replication. We found that N-linked glycosylation is important to the regulation of HSV-1-induced membrane fusion …

Habitat Association Predicts Genetic Diversity And Population Divergence In Amazonian Birds, Michael G. Harvey, Alexandre Aleixo, Camila C. Ribas, Robb T. Brumfield

Faculty Publications

© 2017 by The University of Chicago. The ecological traits of organisms may predict their genetic diversity and population genetic structure and mediate the action of evolutionary processes important for speciation and adaptation. Making these ecological-evolutionary links is difficult because it requires comparable genetic estimates from many species with differing ecologies. In Amazonian birds, habitat association is an important component of ecological diversity. Here, we examine the link between habitat association and genetic parameters using 20 pairs of closely related Amazonian bird species in which one member of the pair occurs primarily in forest edge and floodplains and the other …

Cysteines And N-Glycosylation Sites Conserved Among All Alphaherpesviruses Regulate Membrane Fusion In Herpes Simplex Virus 1 Infection, Paul J.F. Rider, Misagh Naderi, Scott Bergeron, Vladimir N. Chouljenko, Michal Brylinski, Konstantin G. Kousoulas

Faculty Publications

© 2017 American Society for Microbiology. Neurotropism is a defining characteristic of alphaherpesvirus pathogenicity. Glycoprotein K (gK) is a conserved virion glycoprotein of all alphaherpesviruses that is not found in other herpesvirus subfamilies. The extracellular amino terminus of gK has been shown to be important to the ability of the prototypic alphaherpesvirus herpes simplex virus 1 (HSV-1) to enter neurons via axonal termini. Here, we determined the role of the two conserved N-linked glycosylation (N48 and N58) sites of gK in virus-induced cell fusion and replication. We found that N-linked glycosylation is important to the regulation of HSV-1-induced membrane fusion …

Internode Morphometrics And Allometry Of Tonkin Cane Pseudosasa Amabilis, Liang Cheng, Cang Hui, Gadi V.P. Reddy, Yu Long Ding, Pei Jian Shi

Faculty Publications

Pseudosasa amabilis (McClure) (Poales: Gramineae) is a typical bamboo species naturally distributed in large area of south China and famous for its culm strength. Although bamboos were found to share the same development rule, the detailed internode morphology of bamboo culm was actually not fully expressed. We explored internode morphology of P. amabilis using 11 different physical parameters in different dimensions (1–4). As Taylor's power law (TPL) is generally applicable to describe relationship between mean and variance of population density, here we used TPL to evaluate the differences between internodes, and further, the relationship between dimension and TPL. Results showed …

Arthropod Development’S Response To Temperature: A Review And New Software For Modeling, Mohammad Ali Mirhosseini, Yaghoub Fathipour, Gadi V.P. Reddy

Faculty Publications

Among environmental factors, temperature has a direct and crucial influence on the key life processes of survival, development, reproduction, and movement of poikilothermic animals and hence their population dynamics. The lower and upper temperature thresholds and optimal temperature have ramifications for all major life processes, where within a specific range, a temperature change results in a proportional rise or fall of the rate of any given process. There are some basic approaches for modeling development response to temperature in arthropods. The oldest and most widely used model is a simple linear description of arthropod development in relation to temperature.The linear …

Comparison Of Thermal Performance Equations In Describing Temperature-Dependent Developmental Rates Of Insects: (Iii) Phenological Applications, Pei Jian Shi, Mei Ling Fan, Gadi V.P. Reddy

Faculty Publications

The developmental times of poikilotherms at different stages are significantly affected by temperature. Most mathematical models describing the temperature-dependent developmental rates of poikilotherms are built according to the experimental data at various constant temperatures. However, these models can also be applied to the developmental rates at variable temperatures. It is more meaningful to use models to predict the occurrence times of pest insects that actually represent the completion for a particular developmental stage (e.g., hatching, pupation, eclosion) under a natural thermal environment. For some developmental stages, insects might experience a period of high temperatures. In this case, skewed bell-shaped nonlinear …

The Stadium Effect: Rodent Damage Patterns In Rice Fields Explored Using Giving-Up Densities, Clare R. Jones, Renee P. Lorica, James M. Villegas, Angelee F. Ramal, Finbarr G. Horgan, Grant R. Singleton, Alexander M. Stuart

Faculty Publications

Rodents are globally important pre-harvest pests of rice. In Southeast Asia, rodent damage to growing rice crops is commonly concentrated towards the center of rice fields, away from the field edge, resulting in a clear pattern known as the “stadium effect.” To further understand this behavior of rodent pests and to develop recommendations for future research and management, we examined the relation between giving-up densities (GUDs) and damage patterns. In Tanay, Luzon, Philippines, GUD trays containing pieces of coconut in a matrix of sand were placed at 4 different distances from the field edge to quantify the perceived risk of …

Dietary Factors And Fibroblast Growth Factor-23 Levels In Young Adults With African Ancestry, Dominique Kosk, Holly Kramer, Amy Luke, Pauline Camacho, Pascal Bovet, Jacob Plange Rhule, Terrence Forrester, Myles Wolf, Chris Sempos, Michal L. Melamed, Lara R. Dugas, Richard Cooper, Ramon Durazo-Arvizu

Faculty Publications

Fibroblast growth factor-23 (FGF23), a phosphaturic hormone secreted mainly by osteocytes, maintains serum phosphate levels within a tight range by promoting phosphaturia. Previous studies have mainly focused on the link between FGF23 levels and dietary intake of phosphate, but other dietary factors may also influence FGF23 levels. This cross-sectional study pooled three populations of young adults with African ancestry (452 in Chicago, IL, USA; 477 in Victoria, Seychelles; and 482 in Kumasi, Ghana) with estimated glomerular filtration rate >80 ml/min/1.73 m2 to examine the association of dietary factors based on two 24-h recalls with FGF23 levels measured using a C-terminal …

Hybridization Between Mottled Ducks (Anas Fulvigula Maculosa) And Mallards (A. Platyrhynchos) In The Western Gulf Coast Region, Robert J. Ford, Will Selman, Sabrina S. Taylor

Faculty Publications

Hybridization between species that do not normally interbreed has increased due to human impacts on natural environments, such as habitat alteration or introductions of nonnative species. In particular, the introduction of Mallards (Anas platyrhynchos) globally has led to hybridization with many duck species. In the southeastern United States, hybridization with Mallards is a potential threat to the genetic identity of Mottled Ducks (A. fulvigula), a nonmigratory, coastal duck species. Hybridization between Mallards and Mottled Ducks has been examined in South Carolina and Florida, but not extensively in the remaining part of the Mottled Duck range. Mottled Ducks introduced into South …

Social Imaginaries And The Theory Of The Normative Utterance, Meili Steele

Faculty Publications

Theorists of the social imaginary, such as Benedict Anderson, Charles Taylor, Cornelius Castoriadis, and Marcel Gauchet have given us new ways to talk about the structures of the shared meanings and practices of the West. As a group, they have directed their arguments against the narrow horizons of meaning oyed by deliberative political theories in developing their basic normative concepts and principles. Anderson speaks of the new shapes of time and space provided by the novel and newspaper; Taylor and Gauchet discuss the ontological importance of the emergence of secularity, the public sphere, popular sovereignty, and the market; Castoriadis places …

A Communal Catalogue Reveals Earth's Multiscale Microbial Diversity, Luke R. Thompson, Jon G. Sanders, Daniel Mcdonald, Amnon Amir, Joshua Ladau, Kenneth J. Locey, Robert J. Prill, Anupriya Tripathi, Sean M. Gibbons, Gail Ackermann, Jose A. Navas-Molina, Stefan Janssen, Evguenia Kopylova, Yoshiki Vazquez-Baeza, Antonio Gonzalez, James T. Morton, Siavash Mirarab, Zhenjiang Zech Xu, Lingjing Jiang, Mohamed F. Haroon, Jad Kanbar, Qiyun Zhu, Se Jin Song, Tomasz Kosciolek, Nicholas A. Bokulich, Joshua Lefler, Colin J. Brislawn, Gregory Humphrey, Sarah M. Owens, Jarrad Hampton-Marcell, Donna Berg-Lyons, Valerie Mckenzie, Noah Fierer, Jed A. Fuhrman, Aaron Clauset, Rick L. Stevens, Ashley Shade, Katherine S. Pollard, Kelly D. Goodwin, Janet K. Jansson, Jack A. Gilbert, Rob Knight, The Earth Microbiome Project Consortium

Faculty Publications

Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple …

Why Does It Take Two To Tango? Lifetime Fitness Consequences Of Parental Care In A Burying Beetle, Ashlee N. Smith, J. Curtis Creighton, Mark C. Belk

Faculty Publications

In species that require parental care, each parent can either care for their offspring or leave them in the care of the other parent. For each parent this creates three possible parental care strategies: biparental care, uniparental (male or female) care, and uniparental desertion by either the male or female. The burying beetle, Nicrophorus orbicollis, typically exhibits biparental care of offspring, and thus provides a unique system that allows us to compare the fitness benefits of these parental care strategies in an unconfounded way. In this study, we assess the lifetime fitness of biparental care, uniparental care, and uniparental …

Swainson's Thrushes Do Not Show Strong Wing Selectivity Prior To Crossing The Gulf Of Mexico, Rachel T. Bolus, Robert H. Diehl, Frank R. Moore, Jill L. Deppe, Michael P. Ward, Jaclyn Smolinsky, Theodore J. Zenzal Jr.

Faculty Publications

During long-distance fall migrations, nocturnally migrating Swainson’s Thrushes often stop on the northern Gulf of Mexico coast before flying across the Gulf. To minimize energetic costs, trans-Gulf migrants should stop over when they encounter crosswinds or headwinds, and depart with supportive tailwinds. However, time constrained migrants should be less selective, balancing costs of headwinds with benefits of continuing their migrations. To test the hypotheses that birds select supportive winds and that selectivity is mediated by seasonal time constraints, we examined whether local winds affected Swainson’s Thrushes’ arrival and departure at Ft. Morgan, Alabama, USA at annual, seasonal, and nightly time …

The Aspergillus Flavus Homeobox Gene, Hbx1, Is Required For Development And Aflatoxin Production, Jeffrey W. Cary, Pamela Y. Harris-Coward, Leslie Scharfenstein, Brian M. Mack, Perng-Kuang Chang, Qijian Wei, Matthew Lebar, Carol Carter-Wientjes, Rajtilak Majumdar, Chandrani Mitra, Sourav Banerjee, Anindya Chanda

Faculty Publications

Homeobox proteins, a class of well conserved transcription factors, regulate the expression of targeted genes, especially those involved in development. In filamentous fungi, homeobox genes are required for normal conidiogenesis and fruiting body formation. In the present study, we identified eight homeobox (hbx) genes in the aflatoxin-producing ascomycete, Aspergillus flavus, and determined their respective role in growth, conidiation and sclerotial production. Disruption of seven of the eight genes had little to no effect on fungal growth and development. However, disruption of the homeobox gene AFLA_069100, designated as hbx1, in two morphologically different A. flavus strains, CA14 and AF70, resulted in …

Discrete Pre-Processing Step Effects In Registration-Based Pipelines, A Preliminary Volumetric Study On T1-Weighted Images, Nathan M. Muncy, Ariana M. Hedges-Muncy, C. Brock Kirwan

Faculty Publications

Pre-processing MRI scans prior to performing volumetric analyses is common practice in MRI studies. As pre-processing steps adjust the voxel intensities, the space in which the scan exists, and the amount of data in the scan, it is possible that the steps have an effect on the volumetric output. To date, studies have compared between and not within pipelines, and so the impact of each step is unknown. This study aims to quantify the effects of preprocessing steps on volumetric measures in T1-weighted scans within a single pipeline. It was our hypothesis that pre-processing steps would significantly impact ROI volume …

Wyoming Producer Priorities And Perceptions Of Alfalfa Insect Pests, Randa Jabbour, Shiri Noy

Faculty Publications

No abstract provided.

Retinoic Acid Induces White Adipose Tissue Browning By Increasing Adipose Vascularity And Inducing Beige Adipogenesis Of Pdgfrα+ Adipose Progenitors, Bo Wang, Xing Fu, Xingwei Liang, Jeanene M. Deavila, Zhixiu Wang, Liang Zhao, Qiyu Tian, Junxing Zhao, Noe Alberto Gomez, Sophie C. Trombetta, Mei Jun Zhu, Min Du

Faculty Publications

© 2017 The Author(s). Formation of beige adipocytes within white adipose tissue enhances energy expenditure, which is a promising strategy to reduce obesity and prevent metabolic symptoms. Vitamin A and its bioactive metabolite, retinoic acid (RA), have regulatory roles in lipid metabolism. Here we report that RA induces white adipose tissue browning via activating vascular endothelial growth factor (VEGF) signaling. RA triggered angiogenesis and elicited de novo generation of platelet-derived growth factor receptor α positive (PDGFRα +) adipose precursor cells via VEGFA/VEGFR2 signaling. In addition, RA promoted beige/brown adipocyte formation from capillary networks in vitro. Using PDGFRα tracking mice, we …

Soil Carbon Cycling Proxies: Understanding Their Critical Role In Predicting Climate Change Feedbacks, Vanessa L. Bailey, Ben Bond-Lamberty, Kristen M. Deangelis, A. Stuart Grandy, Christine V. Hawkes, Kate Heckman, Kate Lajtha, Richard P. Phillips, Benjamin N. Sulman, Katherine E. O. Todd-Brown, Matthew D. Wallenstein

Faculty Publications

The complexity of processes and interactions that drive soil C dynamics necessitate the use of proxy variables to represent soil characteristics that cannot be directly measured (correlative proxies), or that aggregate information about multiple soil characteristics into one variable (integrative proxies). These proxies have proven useful for understanding the soil C cycle, which is highly variable in both space and time, and are now being used to make predictions of the fate and persistence of C under future climate scenarios. However, the C pools and processes that proxies represent must be thoughtfully considered in order to minimize uncertainties in empirical …

Alpha-Arylphorin Is A Mitogen In The Heliothis Virescens Midgut Cell Secretome Upon Cry1ac Intoxication, Jerreme Jackson, Anais Castagnola, Omaththage P. Perera, Cris Oppert, Shigetoshi Eda, Juan Luis Jurat-Fuentes

Faculty Publications

Insecticidal crystal (Cry) proteins produced by the bacterium Bacillus thuringiensis (Bt) target cells in the midgut epithelium of susceptible larvae. While the mode of action of Cry toxins has been extensively investigated, the midgut response to Cry intoxication and its regulation are not well characterized. In this work, we describe the secreted proteome (secretome) of primary mature midgut cell cultures from Heliothis virescens larvae after exposure to Cry1Ac toxin compared to control buffer treatment. The Cry1Ac-induced secretome caused higher proliferation and differentiation and an overall reduction in total cell mortality over time in primary H. virescens midgut stem cell cultures …

Fibroblast-Specific Tgf-Β-Smad2/3 Signaling Underlies Cardiac Fibrosis, Hadi Khalil, Onur Kanisicak, Vikram Prasad, Robert N. Correll, Xing Fu, Tobias Schips, Ronald J. Vagnozzi, Ruijie Liu, Thanh Huynh, Se Jin Lee, Jason Karch, Jeffery D. Molkentin

Faculty Publications

The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete extracellular matrix proteins. Canonical TGF-β signaling mobilizes Smad2 and Smad3 transcription factors that control fibrosis by promoting gene expression. However, the importance of TGF-β-Smad2/3 signaling in fibroblast-mediated cardiac fibrosis has not been directly evaluated in vivo. Here, we examined pressure overload-induced cardiac fibrosis in fibroblast- and myofibroblast-specific inducible Cre-expressing mouse lines with selective deletion of the TGF-β receptors Tgfbr1/2, Smad2, or Smad3. Fibroblast-specific deletion of Tgfbr1/2 or Smad3, but not Smad2, markedly reduced the pressure overload-induced fibrotic …

Mediodorsal Thalamic Neurons Mirror The Activity Of Medial Prefrontal Neurons Responding To Movement And Reinforcement During A Dynamic Dnmtp Task, Rikki L.A. Miller Phd, Miranda J. Francoeur, Brett M. Gibson, Robert G. Mair

Faculty Publications

The mediodorsal nucleus (MD) interacts with medial prefrontal cortex (mPFC) to support learning and adaptive decision-making. MD receives driver (layer 5) and modulatory (layer 6) projections from PFC and is the main source of driver thalamic projections to middle cortical layers of PFC. Little is known about the activity of MD neurons and their influence on PFC during decision-making. We recorded MD neurons in rats performing a dynamic delayed nonmatching to position (dDNMTP) task and compared results to a previous study of mPFC with the same task (Onos et al., 2016). Criterion event-related responses were observed for 22% …