Digital Commons Network^™

Response Of Liver Metabolic Pathways To Ketogenic Diet And Exercise Are Not Additive, Tai Yu Huang, Felicia R. Goldsmith, Scott E. Fuller, Jacob Simon, Heidi M. Batdorf, Matthew C. Scott, Nabil M. Essajee, John M. Brown, David H. Burk, Christopher D. Morrison, Susan J. Burke, J. Jason Collier, Robert C. Noland

Faculty Publications

© Lippincott Williams & Wilkins. Purpose Studies suggest ketogenic diets (KD) produce favorable outcomes (health and exercise performance); however, most rodent studies have used a low-protein KD, which does not reflect the normal- to high-protein KD used by humans. Liver has an important role in ketoadaptation due to its involvement in gluconeogenesis and ketogenesis. This study was designed to test the hypothesis that exercise training (ExTr) while consuming a normal-protein KD (NPKD) would induce additive/synergistic responses in liver metabolic pathways. Methods Lean, healthy male C57BL/6J mice were fed a low-fat control diet (15.9% kcal protein, 11.9% kcal fat, 72.2% kcal …

Killing The Cat's Paw, Sandra F. Sperino

Faculty Publications

In federal employment discrimination law, courts apply the label "cat's paw" to describe certain cases. Judge Richard Posner first used the term cat's paw in the context of federal discrimination jurisprudence, invoking a fable about an enterprising monkey who tricks a cat into getting hot chestnuts from a fire.' As the cat removes the hot chestnuts from the fire, the monkey eats them, leaving the cat with nothing except burnt paws.

In its traditional form, a cat's paw case is one in which a biased individual passes along negative information about a worker to an "unbiased" decisionmaker. The "unbiased" decisionmaker …

The Nagoya Protocol And The Legal Structure Of Global Biogenomic Research, Sam F. Halabi, Michelle Rourke, Gian Luca Burci, Rebecca Katz

Faculty Publications

As life sciences technologies have advanced, so too has the potential for these international collaborations to lead to breakthrough medicines, enhance food security, and protect ecological systems. The linchpin of this progress is the development of high throughput genetic sequencing technologies. Researchers are now able to generate and compare large stretches of DNA - 1 million bases or more - from different sources quickly and inexpensively. Such comparisons can yield massive amounts of information about the role of inheritance in susceptibility to infection and illness as well as responses to environmental influences. In addition, the ability to sequence genomes more …

Early Access To Unapproved Medicines In The United States And France, Erika Lietzan

Faculty Publications

In 2018, President Trump signed a federal "right to try" law, claiming that it would give desperately ill patients earlier access to unapproved medicines, by allowing the patient, doctor, and drug company to arrange for access without federal oversight. Critics of the law argued that it would not meaningfully increase access to experimental medicines, because federal oversight was not the obstacle in the first place. And they were correct. U.S. law already permitted companies to provide terminally ill patients with early access to unapproved medicines. The problem was instead that companies did not take advantage of this option. This Article …

Use Of Multiple Stream Temperature Logger Models Can Alter Conclusions, Robin M. Rotman, Joanna B. Whittier, Jacob T. Westhoff, Craig P. Paukert

Faculty Publications

Remote temperature loggers are often used to measure water temperatures for ecological studies and by regulatory agencies to determine whether water quality standards are being maintained. Equipment specifications are often given a cursory review in the methods; however, the effect of temperature logger model is rarely addressed in the discussion. In a laboratory environment, we compared measurements from three models of temperature loggers at 5 to 40 °C to better understand the utility of these devices. Mean water temperatures recorded by logger models differed statistically even for those with similar accuracy specifications, but were still within manufacturer accuracy specifications. Maximum …

Online Availability Of Fish Antibiotics And Documented Intent For Self-Medication, Weiwei Zhang, Austin Williams, Nicole Griffith, Jessica Gaskins, P Brandon Bookstaver

Faculty Publications

Self-medication and antibiotic utilization without healthcare oversight may lead to delayed appropriate treatment, transmission of communicable infections, untoward adverse events, and contribute to antimicrobial resistance. Previous data suggest people obtain over-the-counter (OTC) animal antibiotics for their personal use. This study examined the availability of OTC fish antibiotics online and the documented intent for self-medication. The authors conducted a web-based cross-sectional study using Google search engine to identify vendor websites selling fish antibiotics in the United States. Vendor websites were included if product information, consumer reviews, and comments were publicly available. Nine fish antibiotics were chosen due to their possibility of …

Susceptibility Of Swine Cells And Domestic Pigs To Sars-Cov-2, David A. Meekins, Igor Morozov, Jessie D. Trujillo, Natasha N. Gaudreault, Dashzeveg Bold, Mariano Carossino, Bianca L. Artiaga, Sabarish V. Indran, Taeyong Kwon, Velmurugan Balaraman, Daniel W. Madden, Heinz Feldmann, Jamie Henningson, Wenjun Ma, Udeni B. R. Balasuriya, Juergen A. Richt

Faculty Publications

No abstract provided.

Framework For A Community Health Observing System For The Gulf Of Mexico Region: Preparing For Future Disasters, P Sandifer, L Knapp, M Lichtveld, R Manley, P Sandifer, R Caffey, D Cochran, T Collier, K Ebi, L Engel, J Farrington, M Finucane, C Hale, D Halpern, E Harville, L Hart, Y Hswen, B Kirkpatrick, B Mcewen, G Morris, R Orbach, L Palinkas, M Partyka, D Porter, G Prather, T Rowles, G Scott, T Seeman, H Solo-Gabriele, E Svendsen, T Tincher, J Trtanj, A H. Walker, R Yehuda

Faculty Publications

The Gulf of Mexico (GoM) region is prone to disasters, including recurrent oil spills, hurricanes, floods, industrial accidents, harmful algal blooms, and the current COVID-19 pandemic. The GoM and other regions of the U.S. lack sufficient baseline health information to identify, attribute, mitigate, and facilitate prevention of major health effects of disasters. Developing capacity to assess adverse human health consequences of future disasters requires establishment of a comprehensive, sustained community health observing system, similar to the extensive and well-established environmental observing systems. We propose a system that combines six levels of health data domains, beginning with three existing, national surveys …

Who’S Afraid Of Ebola? Epidemic Fires And Locative Fears In The Information Age, W. Shrum, J. Aggrey, A. Campos, J. Pamplona Da Costa, J. Joseph, P. Kreimer, R. Kroeger, L. Medina, P. Miller, A. Palackal, A. Pandal De La Peza, A. Traore

Faculty Publications

Epidemics have traditionally been viewed as the widespread occurrence of infectious disease within a community, or a sudden increase above what is typical. But modern epidemics are both more and less than the diffusion of viral entities. We argue that epidemics are 'fire objects', using a term coined by Law and Singleton: They generate locative fears through encounters that focus attention on entities that are unknown or imprecisely known, transforming spaces and humans into indeterminate dangers, alternating appearance and absence. The Ebola epidemic of 2014 had more complex impacts than the number of infections would suggest. We employ multi-sited qualitative …

Artificial Intelligence And Covid-19: Deep Learning Approaches For Diagnosis And Treatment, M. B. Jamshidi, A. Lalbakhsh, J. Talla, Z. Peroutka, F. Hadjilooei, P Lalbakhsh, M. Jamshidi, L. La Spada, M. Mirmozafari, M. Dehghani, A. Sabet, Sa. Roshani, So. Roshani, N. Bayat-Makou, B. Mohamadzade, Z. Malek, A. Jamshidi, S. Kiani, H. Hashemi-Dezaki, W. Mohyuddin

Faculty Publications

COVID-19 outbreak has put the whole world in an unprecedented difficult situation bringing life around the world to a frightening halt and claiming thousands of lives. Due to COVID-19 & x2019;s spread in 212 countries and territories and increasing numbers of infected cases and death tolls mounting to 5,212,172 and 334,915 (as of May 22 2020), it remains a real threat to the public health system. This paper renders a response to combat the virus through Artificial Intelligence (AI). Some Deep Learning (DL) methods have been illustrated to reach this goal, including Generative Adversarial Networks (GANs), Extreme Learning Machine (ELM), …

Sars-Cov-2 Infection, Disease And Transmission In Domestic Cats, N N. Gaudreault, J D. Trujillo, M Carossino, D A. Meekins, N N. Gaudreault, D W. Madden, S V. Indran, D Bold, V Balaraman, T Kwon, B L. Artiaga, K Cool, A Garcia-Sastre, W J. Ma, W C. Wilson, J Henningson, U Balasuriya, J A. Richt

Faculty Publications

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease 2019 (COVID-19) and responsible for the current pandemic. Recent SARS-CoV-2 susceptibility studies in cats show that the virus can replicate in these companion animals and transmit to other cats. Here, we present an in-depth study of SARS-CoV-2 infection, disease and transmission in domestic cats. Cats were challenged with SARS-CoV-2 via intranasal and oral routes. One day post challenge (DPC), two sentinel cats were introduced. Animals were monitored for clinical signs, clinicopathological abnormalities and viral shedding. Postmortem examinations were performed at 4, 7 and 21 DPC. Viral RNA …

The Role Of Functional Strategies In Global Plant Distribution, Huixuan Liao, Daijiang Li, Ting Zhou, Bei Huang, Haijie Zhang, Baoming Chen, Shaolin Peng

Faculty Publications

© 2020 The Authors. Ecography published by John Wiley & Sons Ltd on behalf of Nordic Society Oikos Understanding the determinants of species distributions is a central topic in ecology. Competition, stress tolerance and colonization, respectively represented by Grime's competitor (C), stress-tolerator (S) and ruderal (R) schemes, are three important functions that interactively influence plant distributions. In this study, we compiled a dataset of 2645 vascular plant species to explore the roles of the CSR strategies in global plant distribution. We analyzed the associations between the CSR scores and species range size with phylogenetic generalized least square (PGLS) models and …

Female Reproductive State Is Associated With Changes In Distinct Arginine Vasotocin Cell Types In The Preoptic Area Of Astatotilapia Burtoni, Julie M. Butler, Chase M. Anselmo, Karen P. Maruska

Faculty Publications

© 2020 Wiley Periodicals LLC Nonapeptides play a crucial role in mediating reproduction, aggression, and parental care across taxa. In fishes, arginine vasotocin (AVT) expression is related to social and/or reproductive status in most male fishes studied to date, and is linked to territorial defense, paternal care, and courtship. Despite a plethora of studies examining AVT in male fishes, relatively little is known about how AVT expression varies with female reproductive state or its role in female social behaviors. We used multiple methods for examining the AVT system in female African cichlid fish Astatotilapia burtoni, including immunohistochemistry for AVT, in …

Speciation-By-Depth On Coral Reefs: Sympatric Divergence With Gene Flow Or Cryptic Transient Isolation?, Carlos Prada, Michael E. Hellberg

Faculty Publications

© 2020 The Authors. Journal of Evolutionary Biology published by John Wiley & Sons Ltd on behalf of European Society for Evolutionary Biology The distributions of many sister species in the sea overlap geographically but are partitioned along depth gradients. The genetic changes leading to depth segregation may evolve in geographic isolation as a prerequisite to coexistence or may emerge during primary divergence leading to new species. These alternatives can now be distinguished via the power endowed by the thousands of scorable loci provided by second-generation sequence data. Here, we revisit the case of two depth-segregated, genetically isolated ecotypes of …

The Avr4 Effector Is Involved In Cercosporin Biosynthesis And Likely Affects The Virulence Of Cercospora Cf. Flagellaris On Soybean, Josielle Santos Rezende, Marija Zivanovic, Maria Izabel Costa De Novaes, Zhi Yuan Chen

Faculty Publications

One of the most devastating fungal diseases of soybean in the southern USA is Cercospora leaf blight (CLB), which is caused mainly by Cercospora cf. flagellaris. Recent studies found that the fungal effector AVR4, originally identified in Cladosporium fulvum as a chitin-binding protein, is highly conserved among other Cercospora species. We wanted to determine whether it is present in C. cf. flagellaris and, if so, whether it plays a role in the pathogen infection of soybean. We cloned the Avr4 gene and created C. cf. flagellaris ∆avr4 mutants, which produced little cercosporin and significantly reduced expression of cercosporin biosynthesis genes. …

Diverging Landscape Impacts On Macronutrient Status Despite Overlapping Diets In Managed (Apis Mellifera) And Native (Melissodes Desponsa) Bees, Christina L. Mogren, Mariá Soledad Benítez, Kevin Mccarter, Frédéric Boyer, Jonathan G. Lundgren

Faculty Publications

Declining pollinator populations worldwide are attributed to multiple stressors, including the loss of quality forage. Habitat management in agricultural areas often targets honey bees (Apis mellifera L.) specifically, with the assumption that native bees will benefit from an 'umbrella species' strategy. We tested this theory using a conservation physiology approach to compare the effects of landscape composition and floral dietary composition on the physiological status of honey bees and Melissodes desponsa in eastern South Dakota, USA. The total glycogen, lipid and protein concentrations were quantified from field collected bees. Next-generation sequencing of the trnL chloroplast gene from bee guts was …

The Buzz About Bee Campuses: Student Thoughts Regarding Pollinator Conservation, Hannah Penn, Jerrod Penn, Macy Hagan, Wuyang Hu

Faculty Publications

No abstract provided.

Using Community Phylogenetics To Assess Phylogenetic Structure In The Fitzcarrald Region Of Western Amazonia, Jack M. Craig, Tiago P. Carvalho, Prosanta Chakrabarty, Valerie Derouen, Hernán Ortega, Paulo Petry, Roberto E. Reis, Victor A. Tagliacollo, James S. Albert

Faculty Publications

© 2020 The Authors. Di versity and Distributions Published by SBI. Here we explore the use of community phylogenetics as a tool to document patterns of biodiversity in the Fitzcarrald region, a remote area in Southwestern Amazonia. For these analyses, we subdivide the region into basin-wide assemblages encompassing the headwaters of four Amazonian tributaries (Urubamba, Yuruá, Purús and Las Piedras basins), and habitat types: river channels, terra firme (non-floodplain) streams, and floodplain lakes. We present a robust, well-documented collection of fishes from the region including 272 species collected from 132 field sites over 63 field days and four years, comprising …

Extensive Paraphyly In The Typical Owl Family (Strigidae), Jessie F. Salter, Carl H. Oliveros, Peter A. Hosner, Joseph D. Manthey, Mark B. Robbins, Robert G. Moyle, Robb T. Brumfield, Brant C. Faircloth

Faculty Publications

© 2019 American Ornithological Society 2019. Published by Oxford University Press for the American Ornithological Society. The typical owl family (Strigidae) comprises 194 species in 28 genera, 14 of which are monotypic. Relationships within and among genera in the typical owls have been challenging to discern because mitochondrial data have produced equivocal results and because many monotypic genera have been omitted from previous molecular analyses. Here, we collected and analyzed DNA sequences of ultraconserved elements (UCEs) from 43 species of typical owls to produce concatenated and multispecies coalescent-based phylogenetic hypotheses for all but one genus in the typical owl family. …

Interspecific Variation In Hypoxia Tolerance And Hypoxia Acclimation Responses In Killifish From The Family Fundulidae, Brittney G. Borowiec, Ryan D. Hoffman, Chelsea D. Hess, Fernando Galvez, Graham R. Scott

Faculty Publications

© 2020. Published by The Company of Biologists Ltd Hypoxia is a pervasive stressor in aquatic environments, and both phenotypic plasticity and evolutionary adaptation could shape the ability to cope with hypoxia. We investigated evolved variation in hypoxia tolerance and the hypoxia acclimation response across fundulid killifishes that naturally experience different patterns of hypoxia exposure. We compared resting O2 consumption rate (M O2), and various indices of hypoxia tolerance [critical O2 tension (Pcrit), regulation index (RI), O2 tension (PO2) at loss of equilibrium (PLOE) and time to LOE (tLOE) at 0.6 kPa O2] in Fundulus confluentus, Fundulus diaphanus, Fundulus heteroclitus, …

Marine Wild-Capture Fisheries After Nuclear War, K.J.N. Scherrer, C.S. Harrison, R.F. Heneghan, E. Galbraith, C.G. Bardeen, J. Coupe, J. Jägermeyr, N.S. Lovenduski, A. Luna, A. Robock, J. Stevens, S. Stevenson, O.B. Toon, L. Xia

Faculty Publications

No abstract provided.

Small Ceramide Tames Big P53 Mutant Beast, Ronald A. Hill, Zhijun Liu, Yong Yu Liu

Faculty Publications

No abstract provided.

Emerging Infectious Disease, The Household Built Environment Characteristics, And Urban Planning: Evidence On Avian Influenza In Vietnam, James H. Spencer, Melissa L. Finucane, Jefferson M. Fox, Sumeet Saksena, Nargis Sultana

Faculty Publications

Recent concerns with pandemic outbreaks of human disease and their origins in animal populations have ignited concerns regarding connections between Emerging Infectious Diseases (EID) and development. As disasters, health, and infectious disease become part of planning concern (Matthew & McDonald, 2007), greater focus on household infrastructure and EID disease outbreaks among poultry is warranted. Following Spencer (2013), this study examines the relationship between the mix of household-scale water supplies, sanitation systems, and construction materials, and Highly Pathogenic Avian Influenza (HPAI) among poultry in a developing country: Vietnam. Findings of our multivariate logistic regressions suggest that a non-linear, Kuznets-shaped urban transition …

Korematzu, Hirabayashi, And The Second Monster, Eric L. Muller

Faculty Publications

It is a trope at least as old as Beowulf: the unexpected second monster. Beowulf arrives in Heorot to take on Grendel, the demon who has been terrorizing the Ring-Danes’ mead-hall. He bests the monster in battle and Grendel slinks off, one-armed and bloodied, to die. The Ring-Danes honor Beowulf with a great banquet; he has slaughtered their nemesis and there is much to celebrate. Full of mead and a newfound sense of safety, the revelers drift off to sleep. That is when a terrible new monster bursts upon the scene—Grendel’s mother, the beast that brought Grendel into the …

The Death Of Custom: Winners And Losers In The Legal Transformation Of Peri-Urban Land In Niger, Thomas A. Kelley Iii

Faculty Publications

No abstract provided.

Identity: Obstacles And Openings, Osamudia James

Faculty Publications

No abstract provided.

Future Work, Jeffrey M. Hirsch

Faculty Publications

The Industrial Revolution. The Digital Age. These revolutions radi-cally altered the workplace and society. We may be on the cusp of a new era -- one that will rival or even surpass these historical disruptions. Technology such as artificial intelligence, robotics, virtual reality, and cutting-edge monitoring devices are developing at a rapid pace. These technologies have already begun to infiltrate the workplace and will continue to do so at ever increasing speed and breadth.

This Article addresses the impact of these emerging technologies on the workplace of the present and the future. Drawing upon interviews with leading technologists, the Article …

Fake News On Trial: The Jury Trial As A Guard Against Societal Entropy, Neil Fulton

Faculty Publications

No abstract provided.

Pollution And Polluter Pays, Aaron Lercher

Faculty Publications

No abstract provided.

El Día Del Señor, Grande Y Terrible’: El Poder De Las Emociones Y El Lenguaje Emotivo En Los Textos Bíblicos Apocalípticos, Chantal J. Klingbeil, Gerald A. Klingbeil

Faculty Publications

No abstract provided.