Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Law (1074)
- Life Sciences (913)
- Arts and Humanities (683)
- Social and Behavioral Sciences (615)
- Religion (378)
-
- Physical Sciences and Mathematics (339)
- Biology (336)
- Medicine and Health Sciences (305)
- Biblical Studies (187)
- Engineering (180)
- Public Health (160)
- Psychology (150)
- Animal Sciences (122)
- Anthropology (114)
- Constitutional Law (107)
- Education (107)
- Business (101)
- Forest Sciences (101)
- Practical Theology (99)
- History (87)
- Marine Biology (79)
- Library and Information Science (71)
- Earth Sciences (70)
- Geography (69)
- Chemistry (67)
- Environmental Law (64)
- Communication (62)
- Religious Thought, Theology and Philosophy of Religion (61)
- Public Health Education and Promotion (57)
- Ecology and Evolutionary Biology (55)
- Institution
-
- Louisiana State University (2609)
- University of South Carolina (715)
- Brigham Young University (608)
- The University of Southern Mississippi (415)
- Andrews University (396)
-
- William & Mary Law School (302)
- Stephen F. Austin State University (213)
- San Jose State University (138)
- University of Missouri School of Law (136)
- University of New Hampshire (127)
- University of North Carolina School of Law (116)
- Santa Clara Law (113)
- Case Western Reserve University School of Law (85)
- University of South Dakota (82)
- Luther Seminary (63)
- Denison University (58)
- St. John's University School of Law (55)
- University of Northern Iowa (54)
- Marquette University Law School (52)
- Florida International University College of Law (50)
- Villanova University Charles Widger School of Law (50)
- Rollins College (49)
- Linfield University (46)
- Texas Southern University (41)
- Hope College (36)
- Air Force Institute of Technology (31)
- University of Southern Maine (25)
- University of Maine School of Law (19)
- Santa Clara University (18)
- Macalester College (15)
- Keyword
-
- Climate change (65)
- Inflammation (49)
- Theology (46)
- Law (42)
- Biology (39)
-
- Obesity (36)
- Biodiversity (34)
- Biblical Studies (33)
- Archaeology (31)
- Humans (31)
- Constitutional Law (30)
- Evolution (29)
- Church History (28)
- Animals (27)
- Diet (26)
- Reproduction (26)
- United States (26)
- Ecology (25)
- Gene expression (25)
- Old Testament (24)
- Chemistry (23)
- Economics (22)
- Nutrition (22)
- Public Health (22)
- Religion (22)
- Teleost (22)
- Devins works (21)
- Gulf of Mexico (21)
- Migration (21)
- Phylogeny (21)
- Publication Year
- File Type
Articles 1591 - 1620 of 6811
Full-Text Articles in Entire DC Network
Advances In The Neurophysiology Of Magnocellular Neuroendocrine Cells, Jeffrey G. Tasker, Masha Prager-Khoutorsky, Ryoichi Teruyama, José R. Lemos, William E. Amstrong
Advances In The Neurophysiology Of Magnocellular Neuroendocrine Cells, Jeffrey G. Tasker, Masha Prager-Khoutorsky, Ryoichi Teruyama, José R. Lemos, William E. Amstrong
Faculty Publications
© 2020 British Society for Neuroendocrinology Hypothalamic magnocellular neuroendocrine cells have unique electrical properties and a remarkable capacity for morphological and synaptic plasticity. Their large somatic size, their relatively uniform and dense clustering in the supraoptic and paraventricular nuclei, and their large axon terminals in the neurohypophysis make them an attractive target for direct electrophysiological interrogation. Here, we provide a brief review of significant recent findings in the neuroplasticity and neurophysiological properties of these neurones that were presented at the symposium “Electrophysiology of Magnocellular Neurons” during the 13th World Congress on Neurohypophysial Hormones in Ein Gedi, Israel in April 2019. …
Effects Of Sea-Level Rise On Physiological Ecology Of Populations Of A Ground-Dwelling Ant, L. M. Hooper-Bùi, R. M. Strecker-Lau, D. M. Stewart, M. J. Landry, A. M. Papillion, S. N. Peterson, R. A. Daniel
Effects Of Sea-Level Rise On Physiological Ecology Of Populations Of A Ground-Dwelling Ant, L. M. Hooper-Bùi, R. M. Strecker-Lau, D. M. Stewart, M. J. Landry, A. M. Papillion, S. N. Peterson, R. A. Daniel
Faculty Publications
Introduction Sea-level rise is a consequence of climate change that can impact the ecological and physiological changes of coastal, ground-dwelling species. Sea-level rise has a potential to inundate birds, rodents, spiders, and insects that live on the ground in coastal areas. Yet, there is still much to be learned concerning the specifics of these impacts. The red imported fire ant Solenopsis invicta (Buren) excavates soil for its home and is capable of surviving flooding. Because of their ground-dwelling life history and rapid reproduction, fire ants make an ideal model for discovery and prediction of changes that may be due to …
Nucleolar Stress In Drosophila Neuroblasts, A Model For Human Ribosomopathies, Sonu Shrestha Baral, Molly E. Lieux, Patrick J. Dimario
Nucleolar Stress In Drosophila Neuroblasts, A Model For Human Ribosomopathies, Sonu Shrestha Baral, Molly E. Lieux, Patrick J. Dimario
Faculty Publications
Different stem cells or progenitor cells display variable threshold requirements for functional ribosomes. This is particularly true for several human ribosomopathies in which select embryonic neural crest cells or adult bone marrow stem cells, but not others, show lethality due to failures in ribosome biogenesis or function (now known as nucleolar stress). To determine if various Drosophila neuroblasts display differential sensitivities to nucleolar stress, we used CRISPR-Cas9 to disrupt the Nopp140 gene that encodes two splice variant ribosome biogenesis factors (RBFs). Disruption of Nopp140 induced nucleolar stress that arrested larvae in the second instar stage. While the majority of larval …
Environmental Control On The Distribution Of Metabolic Strategies Of Benthic Microbial Mats In Lake Fryxell, Antarctica, Megan L. Dillon, Ian Hawes, Anne D. Jungblut, Tyler J. Mackey, Jonathan A. Eisen, Peter T. Doran, Dawn Y. Sumner
Environmental Control On The Distribution Of Metabolic Strategies Of Benthic Microbial Mats In Lake Fryxell, Antarctica, Megan L. Dillon, Ian Hawes, Anne D. Jungblut, Tyler J. Mackey, Jonathan A. Eisen, Peter T. Doran, Dawn Y. Sumner
Faculty Publications
© 2020 Dillon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Ecological theories posit that heterogeneity in environmental conditions greatly affects community structure and function. However, the degree to which ecological theory developed using plant- and animal-dominated systems applies to microbiomes is unclear. Investigating the metabolic strategies found in microbiomes are particularly informative for testing the universality of ecological theories because microorganisms have far wider metabolic capacity than plants and animals. We …
An Argument Against Satellite Resiliency: Simplicity In The Face Of Modern Satellite Design, Dax Linville, Robert A. Bettinger
An Argument Against Satellite Resiliency: Simplicity In The Face Of Modern Satellite Design, Dax Linville, Robert A. Bettinger
Faculty Publications
The US Air Force and the wider US government rely heavily on space-based capabilities in various orbital regimes to project national security and sovereignty. However, these capabilities are enabled by the design, launch, and operation of satellites produced with a design methodology that favors large, monolithic, and technologically exquisite space systems. Despite the ability for these satellites to provide enduring and resilient capabilities, they suffer from a woefully long acquisition process that debilitates any prospect of rapid satellite reconstitution in the event of a space war.
Community Dynamics Of Fish Assemblages On Mid-Shelf And Outer-Shelf Coral Reefs In The Northwestern Gulf Of Mexico, Lynne S. Wetmore, Michael A. Dance, Ronald L. Hill, Jay R. Rooker
Community Dynamics Of Fish Assemblages On Mid-Shelf And Outer-Shelf Coral Reefs In The Northwestern Gulf Of Mexico, Lynne S. Wetmore, Michael A. Dance, Ronald L. Hill, Jay R. Rooker
Faculty Publications
Offshore coral reefs in the Gulf of Mexico (GOM) are unique model systems for examining the mechanisms structuring reef fish communities due to their substantial geographic isolation, and the presence of replicate experimental units of both low (mid-shelf) and high coral diversity (shelf-edge) reefs. Here, we examined the species assemblage structure of juvenile and adult fishes at two mid-shelf reefs (Sonnier and Stetson Bank) and two shelf-edge reefs (East and West Flower Garden Banks) in the northwestern GOM to evaluate the relative importance of habitat (i.e., coral diversity) vs. recruitment in structuring resident fish assemblages. Visual reef fish surveys (n …
Traditional Funeral And Burial Rituals And Ebola Outbreaks In West Africa: A Narrative Review Of Causes And Strategy Interventions, Chulwoo Park
Faculty Publications
Introduction: In West Africa, traditional funerals and burials have proven main contributors to the spread of infectious diseases, such as Ebola, plague, the Marburg virus, and others. Although the World Health Organization has provided guidelines for the safe burial process after learning of the culture of the afterlife in Ebola-affected areas, little effort has been made to integrate theoretical interventions and models for changing West Africans’ funeral behavior. This research was conducted to study 1) the background of traditional burial rituals, 2) interventions to contain Ebola outbreaks in West Africa, and 3) a strategic approach to future disease outbreak in …
Listeria Monocytogenes Response To Anaerobic Environments, Brandy N. Roberts, Damayanti Chakravarty, J.C. Gardner Iii, Steven C. Ricke, Janet R. Donaldson
Listeria Monocytogenes Response To Anaerobic Environments, Brandy N. Roberts, Damayanti Chakravarty, J.C. Gardner Iii, Steven C. Ricke, Janet R. Donaldson
Faculty Publications
Listeria monocytogenes is a Gram-positive facultative anaerobic bacterium that is responsible for the disease, listeriosis. It is particularly lethal in pregnant women, the fetus, the elderly and the immunocompromised. The pathogen survives and replicates over a wide range of temperatures (4 to 42 °C), pH, salt and oxygen concentrations. Because it can withstand various environments, L. monocytogenes is a major concern in food processing industries, especially in dairy products and ready-to-eat fruits, vegetables and deli meats. The environment in which the pathogen is exposed can influence the expression of virulence genes. For instance, studies have shown that variations in oxygen …
Hyaluronic Acid-Cellulose Composites As Patches For Minimizing Bacterial Infections, Kelsey M. Lopez, Sudhir Ravula, Rocío L. Pérez, Caitlan E. Ayala, Jack N. Losso, Marlene E. Janes, Isiah M. Warner
Hyaluronic Acid-Cellulose Composites As Patches For Minimizing Bacterial Infections, Kelsey M. Lopez, Sudhir Ravula, Rocío L. Pérez, Caitlan E. Ayala, Jack N. Losso, Marlene E. Janes, Isiah M. Warner
Faculty Publications
Copyright © 2020 American Chemical Society. A facile method was used to synthesize biocomposites containing differing ratios of hyaluronic acid (HA) and cellulose (CEL). Based on the properties of the individual polymers, the resultant composite materials may have potentially great wound care properties. In the method outlined here, 1-butyl-3-methylimidazolium chloride ([Bmim][Cl]), a simple ionic liquid, was used as the sole solvent without chemical modifiers to dissolve the biopolymers at ratios of 1:1 and 2:1 HA to CEL. This method was completely recyclable since the ionic liquid, [Bmim][Cl], can be recovered. Results from spectroscopic measurements [Fourier transform infrared (FT-IR) and X-ray …
A New Ectotherm 3d Tracking And Behavior Analytics System Using A Depth-Based Approach With Color Validation, With Preliminary Data On Kihansi Spray Toad (Nectophrynoides Asperginis) Activity, Philip Bal, Damian Lyons, Avishai Shuter
A New Ectotherm 3d Tracking And Behavior Analytics System Using A Depth-Based Approach With Color Validation, With Preliminary Data On Kihansi Spray Toad (Nectophrynoides Asperginis) Activity, Philip Bal, Damian Lyons, Avishai Shuter
Faculty Publications
The Kihansi spray toad (Nectophrynoides asperginis), classified as Extinct in the Wild by the IUCN, is being bred at the Wildlife Conservation Society’s (WCS) Bronx Zoo as part of an effort to successfully reintroduce the species into the wild. Thousands of toads live at the Bronx Zoo presenting an opportunity to learn more about their behaviors for the first time, at scale. It is impractical to perform manual observations for long periods of time. This paper reports on the development of a RGB-D tracking and analytics approach that allows researchers to accurately and efficiently gather information about the toads’ behavior. …
Heat Shock Protein 70 Levels And Post-Harvest Survival Of Eastern Oysters Following Sublethal Heat Shock In The Laboratory Or Conditioning In The Field, Sandra M. Casas, Jerome F. La Peyre
Heat Shock Protein 70 Levels And Post-Harvest Survival Of Eastern Oysters Following Sublethal Heat Shock In The Laboratory Or Conditioning In The Field, Sandra M. Casas, Jerome F. La Peyre
Faculty Publications
© 2020, Cell Stress Society International. A major problem of storing and shipping eastern oysters (Crassostrea virginica) from the Northern Gulf of Mexico in summer and early fall is their elevated mortality. A study was therefore conducted to determine whether heat shocking the oysters or conditioning them to aerial exposure prior to harvest could reduce their mortality during cold storage. Increasing the levels of stress proteins in bivalves has been shown to reduce their mortality when exposed to additional stressors. In this study, the levels of heat shock protein 70 (HSP70) proteins and cumulative mortality during cold storage, out of …
Genome-Wide Association Study To Identify Genetic Loci Associated With Gastrointestinal Nematode Resistance In Katahdin Sheep, G. M. Becker, K. M. Davenport, J. M. Burke, R. M. Lewis, J. E. Miller, J. L.M. Morgan, D. R. Notter, B. M. Murdoch
Genome-Wide Association Study To Identify Genetic Loci Associated With Gastrointestinal Nematode Resistance In Katahdin Sheep, G. M. Becker, K. M. Davenport, J. M. Burke, R. M. Lewis, J. E. Miller, J. L.M. Morgan, D. R. Notter, B. M. Murdoch
Faculty Publications
© 2020 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics Resistance to gastrointestinal nematodes has previously been shown to be a moderately heritable trait in some breeds of sheep, but the mechanisms of resistance are not well understood. Selection for resistance currently relies upon faecal egg counts (FEC), blood packed cell volumes and FAMACHA visual indicator scores of anaemia. Identifying genomic markers associated with disease resistance would potentially improve the selection process and provide a more reliable means of classifying and understanding the biology behind resistant and susceptible …
The Relative Importance Of Local And Regional Processes To Metapopulation Dynamics, Tad A. Dallas, Marjo Saastamoinen, Torsti Schulz, Otso Ovaskainen
The Relative Importance Of Local And Regional Processes To Metapopulation Dynamics, Tad A. Dallas, Marjo Saastamoinen, Torsti Schulz, Otso Ovaskainen
Faculty Publications
© 2019 The Authors. Journal of Animal Ecology © 2019 British Ecological Society Metapopulation dynamics – patch occupancy, colonization and extinction – are the result of complex processes at both local (e.g. environmental conditions) and regional (e.g. spatial arrangement of habitat patches) scales. A large body of work has focused on habitat patch area and connectivity (area-isolation paradigm). However, these approaches often do not incorporate local environmental conditions or fully address how the spatial arrangement of habitat patches (and resulting connectivity) can influence metapopulation dynamics. Here, we utilize long-term data on a classic metapopulation system – the Glanville fritillary butterfly …
Potential Population Growth Of Melanaphis Sacchari (Zehntner) (Hemiptera: Aphididae) Under Six Constant Temperatures On Grain Sorghum (Sorghum Bicolor L.), M. F. Souza, J. A. Davis
Potential Population Growth Of Melanaphis Sacchari (Zehntner) (Hemiptera: Aphididae) Under Six Constant Temperatures On Grain Sorghum (Sorghum Bicolor L.), M. F. Souza, J. A. Davis
Faculty Publications
Sugarcane aphid, Melanaphis sacchari Zehntner (Hemiptera: Aphididae), is now widely established in sorghum, Sorghum bicolor (L.) Moench (Poaceae), production areas of the USA, and is an important economic pest. To calculate economic thresholds, population growth parameters under varied temperature conditions are needed. However, detailed laboratory studies of temperature effects on the biology and population parameters of M. sacchari since the sorghum outbreak in the US have not been performed previously. Therefore, this study evaluated the response of M. sacchari to 6 different constant temperatures (15, 20, 25, 30, 32, and 35 °C) on sorghum tissue. Aphid development, age-specific survivorship, fecundity, …
Insect Herbivores Associated With Nymphaea Mexicana (Nymphaeaceae) In Southern United States: Potential Biological Control Agents For South Africa, Megan K. Reid, Julie A. Coetzee, Martin P. Hill, Rodrigo Diaz, Lyn A. Gettys, James P. Cuda, Christopher S. Reid
Insect Herbivores Associated With Nymphaea Mexicana (Nymphaeaceae) In Southern United States: Potential Biological Control Agents For South Africa, Megan K. Reid, Julie A. Coetzee, Martin P. Hill, Rodrigo Diaz, Lyn A. Gettys, James P. Cuda, Christopher S. Reid
Faculty Publications
Nymphaea mexicana Zuccarini (Nymphaeaceae) (Mexican waterlily) is an emergent floating-leaved aquatic plant from the southeastern USA that is invasive in South Africa. In invaded waterbodies this plant restricts water movement, increases siltation, decreases recreational activities, and can deplete water oxygen levels, which in turn negatively impacts aquatic fauna. Currently there are no chemical, mechanical, or biological control programs in place for N. mexicana in South Africa, but the sustainability of biological control makes this the most desirable option. Field surveys for potential biological control agents were conducted in the native range of N. mexicana in Florida, Louisiana, and Texas from …
A Target Enrichment Bait Set For Studying Relationships Among Ostariophysan Fishes, Brant C. Faircloth, Fernando Alda, Kendra Hoekzema, Michael D. Burns, Claudio Oliveira, James S. Albert, Bruno F. Melo, Luz E. Ochoa, Fábio F. Roxo, Prosanta Chakrabarty, Brian L. Sidlauskas, Michael E. Alfaro
A Target Enrichment Bait Set For Studying Relationships Among Ostariophysan Fishes, Brant C. Faircloth, Fernando Alda, Kendra Hoekzema, Michael D. Burns, Claudio Oliveira, James S. Albert, Bruno F. Melo, Luz E. Ochoa, Fábio F. Roxo, Prosanta Chakrabarty, Brian L. Sidlauskas, Michael E. Alfaro
Faculty Publications
© 2020 by the American Society of Ichthyologists and Herpetologists. Target enrichment of conserved nuclear loci has helped reconstruct evolutionary relationships among a wide variety of species. While there are preexisting bait sets to enrich a few hundred loci across all fishes or a thousand loci from acanthomorph fishes, no bait set exists to enrich large numbers (>1,000 loci) of ultraconserved nuclear loci from ostariophysans, the second largest actinopterygian superorder. In this study, we describe how we designed a bait set to enrich 2,708 ultraconserved nuclear loci from ostariophysan fishes by combining an existing genome assembly with low coverage …
Spatial And Pregnancy-Related Changes In The Protein, Amino Acid, And Carbohydrate Composition Of Bovine Oviduct Fluid, Beatriz Rodríguez-Alonso, Veronica Maillo, Omar Salvador Acuña, Rebeca López-Úbeda, Alejandro Torrecillas, Constantine A. Simintiras, Roger Sturmey, Manuel Avilés, Patrick Lonergan, Dimitrios Rizos
Spatial And Pregnancy-Related Changes In The Protein, Amino Acid, And Carbohydrate Composition Of Bovine Oviduct Fluid, Beatriz Rodríguez-Alonso, Veronica Maillo, Omar Salvador Acuña, Rebeca López-Úbeda, Alejandro Torrecillas, Constantine A. Simintiras, Roger Sturmey, Manuel Avilés, Patrick Lonergan, Dimitrios Rizos
Faculty Publications
Knowledge of how the biochemical composition of the bovine oviduct is altered due to the oviduct anatomy or the presence of an embryo is lacking. Thus, the aim of this study was to assess the effect of (І) oviduct anatomy and (ІІ) embryo presence on oviductal fluid (OF) protein, amino acid, and carbohydrate composition. Cross-bred beef heifers (n = 19) were synchronized and those in standing estrus were randomly allocated to a cyclic (non-bred) or pregnant (artificially inseminated) group. All heifers were slaughtered on Day 3 after estrus. The oviducts ipsilateral to the corpus luteum from each animal were isolated, …
Pollen Placement On Petals, Kyle E. Harms
Synthesis Of Praseodymium-And Molybdenum- Sulfide Nanoparticles For Dye-Photodegradation And Near-Infrared Deep-Tissue Imaging, Ye Wu, Pengfei Ou, Jun Song, Ling Zhang, Yingcheng Lin, Pengfei Song, Jian Xu
Synthesis Of Praseodymium-And Molybdenum- Sulfide Nanoparticles For Dye-Photodegradation And Near-Infrared Deep-Tissue Imaging, Ye Wu, Pengfei Ou, Jun Song, Ling Zhang, Yingcheng Lin, Pengfei Song, Jian Xu
Faculty Publications
Development of nanoparticles with multi-functionalities is of great importance. In this study, praseodymium sulfide (Pr2S3) and molybdenum sulfide (MoS2) nanoparticles were synthesized. The structural, morphological and optical properties of the as-obtained products were investigated by XRD, XPS, TEM, UV-vis-NIR spectroscopy, and photoluminescence spectroscopy. Pr2S3 is found to be used in selective photodegradation of fluorescein sodium salt. MoS2 can be utilized for selective photodegradation of rhodamine B. In the mixture of rhodamine B, fluorescein sodium salt and rhodamine 6 G, most of rhodamine B and part of fluorescein sodium salt are optically degraded by Pr2S3. In the mixture of rhodamine B, …
Candidate Privacy, Rebecca Green
Candidate Privacy, Rebecca Green
Faculty Publications
In the United States, we have long accepted that candidates for public office who have voluntarily stepped into the public eye sacrifice claims to privacy. This refrain is rooted deep within the American enterprise, emanating from the Framers' concept of the informed citizen as a bedrock of democracy. Voters must have full information about candidates to make their choices at the ballot box. Even as privacy rights for ordinary citizens have expanded, privacy theorists and courts continue to exempt candidates from privacy protections. This Article suggests that two disruptions warrant revisiting the privacy interests of candidates. The first is a …
When Agencies Make Criminal Law, Brenner M. Fissell
When Agencies Make Criminal Law, Brenner M. Fissell
Faculty Publications
The nondelegation doctrine prohibits a legislature from delegating its power to an administrative agency, yet it is famously underenforced—even when the delegation results in the creation of criminal offenses (so-called “administrative crimes”). While this practice appears to scandalize the hornbook presumption that legislatures alone define criminal offenses, it has long been ratified by the Supreme Court and has received little scholarly attention. The few commentators who have addressed administrative crimes highlight the intuition that criminal sanctions are uniquely severe and thus deserving of a more rigorous nondelegation analysis, but they stop there. They do not precisely link the severe aspects …
Introduction To Computational Thinking: A New High School Curriculum Using Codeworld, Fernando Alegre, John Underwoood, Juana Moreno
Introduction To Computational Thinking: A New High School Curriculum Using Codeworld, Fernando Alegre, John Underwoood, Juana Moreno
Faculty Publications
The Louisiana Department of Education partnered with the Gordon A. Cain Center at LSU to pilot a Computing High School Graduation Pathway. The first course in the pathway, Introduction to Computational Thinking (ICT), is designed to teach programming and reinforce mathematical practice skills of nine-grade students, with an emphasis on promoting higher order thinking. In 2017- 18, about 200 students and five teachers participated in the pilot, in 2018-2019 the participation increased to 400 students, and in the current 2019-2020 year about 800 students in 11 schools are involved. After describing the course content and the teacher training, we briefly …
Phase 2 Study Of Vismodegib, A Hedgehog Inhibitor, Combined With Gemcitabine And Nab-Paclitaxel In Patients With Untreated Metastatic Pancreatic Adenocarcinoma, Ana De Jesus-Acosta, Elizabeth A. Sugar, Peter J. O’Dwyer, Ramesh K. Ramanathan, Daniel D. Von Hoff, Zeshaan Rasheed, Lei Zheng, Asma Begum, Robert Anders, Anirban Maitra, Florencia Mcallister, N. V. Rajeshkumar, Shinichi Yabuuchi, Roeland F. De Wilde, Bhavina Batukbhai, Ismet Sahin, Daniel A. Laheru
Phase 2 Study Of Vismodegib, A Hedgehog Inhibitor, Combined With Gemcitabine And Nab-Paclitaxel In Patients With Untreated Metastatic Pancreatic Adenocarcinoma, Ana De Jesus-Acosta, Elizabeth A. Sugar, Peter J. O’Dwyer, Ramesh K. Ramanathan, Daniel D. Von Hoff, Zeshaan Rasheed, Lei Zheng, Asma Begum, Robert Anders, Anirban Maitra, Florencia Mcallister, N. V. Rajeshkumar, Shinichi Yabuuchi, Roeland F. De Wilde, Bhavina Batukbhai, Ismet Sahin, Daniel A. Laheru
Faculty Publications
Background: The Hedgehog (Hh) signalling pathway is overexpressed in pancreatic ductal adenocarcinoma (PDA). Preclinical studies have shown that Hh inhibitors reduce pancreatic cancer stem cells (pCSC), stroma and Hh signalling. Methods: Patients with previously untreated metastatic PDA were treated with gemcitabine and nab-paclitaxel. Vismodegib was added starting on the second cycle. The primary endpoint was progression-free survival (PFS) as compared with historical controls. Tumour biopsies to assess pCSC, stroma and Hh signalling were obtained before treatment and after cycle 1 (gemcitabine and nab-paclitaxel) or after cycle 2 (gemcitabine and nab-paclitaxel plus vismodegib). Results: Seventy-one patients were enrolled. Median PFS and …
Model Sensitivity To Topographic Uncertainty In Meso- And Microtidal Marshes, Karim Alizad, Stephen C. Medeiros, Madeline R. Foster-Martinez, Scott C. Hagen
Model Sensitivity To Topographic Uncertainty In Meso- And Microtidal Marshes, Karim Alizad, Stephen C. Medeiros, Madeline R. Foster-Martinez, Scott C. Hagen
Faculty Publications
Light detection and ranging (Lidar) derived digital elevation models are widely used in modeling coastal marsh systems. However, the topographic error in these models can affect simulations of marsh coverage and characteristics. We investigated the relevance and impact of this error in micro- and mesotidal systems. Lidar-derived and RTK-adjusted topography were each used in a dynamic marsh model, and the resulting marsh coverages were examined. For two microtidal sites (Apalachicola, FL, USA, and Grand Bay, MS, USA) using solely lidar-derived topography, the model produced Cohen Kappa values of 0.1 for both estuaries when compared with National Wetland Inventory data indicating …
Respiration By The Opportunistic Spionid Polychaete Streblospio Gynobranchiata During Adjustment To And Recovery From Moderate Hypoxia, Alyssa D. Bennett, Chet F. Rakocinski
Respiration By The Opportunistic Spionid Polychaete Streblospio Gynobranchiata During Adjustment To And Recovery From Moderate Hypoxia, Alyssa D. Bennett, Chet F. Rakocinski
Faculty Publications
Understanding the capacity of estuarine organisms to acclimate to stressful conditions provides insights into how communities cope within fluctuating environments. The opportunistic spionid polychaete, Streblospio gynobranchiata Rice and Levin, 1998, regularly experiences intermittent moderate hypoxia within shallow sedimentary habitats. To better understand fine-scale adjustments by this opportunistic species to short-term moderate hypoxia, the aerobic respiration response of three size classes was examined over a 12 h period and after 24 h of exposure to moderate hypoxia (i.e., 20% air saturation) at 25 °C. In addition, the capacity to resume standard respiration was examined over a 12 h period following a …
Geology Of Nacogdoches, Texas: Texas Academy Of Science March 1, 2020, R. Larell Nielson, Mike Read, Mindy Faulkner, Hannah C. Chambers, Jessica O'Neal
Geology Of Nacogdoches, Texas: Texas Academy Of Science March 1, 2020, R. Larell Nielson, Mike Read, Mindy Faulkner, Hannah C. Chambers, Jessica O'Neal
Faculty Publications
No abstract provided.
Prototyping A Social Media Flooding Photo Screening System Based On Deep Learning, Zhenlong Li Huan Ning, Michael E. Hodgson, Cuizhen Wang
Prototyping A Social Media Flooding Photo Screening System Based On Deep Learning, Zhenlong Li Huan Ning, Michael E. Hodgson, Cuizhen Wang
Faculty Publications
This article aims to implement a prototype screening system to identify flooding-related photos from social media. These photos, associated with their geographic locations, can provide free, timely, and reliable visual information about flood events to the decision-makers. This screening system, designed for application to social media images, includes several key modules: tweet/image downloading, flooding photo detection, and aWebGIS application for human verification. In this study, a training dataset of 4800 flooding photos was built based on an iterative method using a convolutional neural network (CNN) developed and trained to detect flooding photos. The system was designed in a way that …
It Looks A Bit Like This: Prototyping In An Academic Library, Holt Zaugg, Elise Silva, Greg M. Nelson, Cyndee Frasier
It Looks A Bit Like This: Prototyping In An Academic Library, Holt Zaugg, Elise Silva, Greg M. Nelson, Cyndee Frasier
Faculty Publications
Prototyping is an incremental process that facilitates those looking to make changes in products, services, or resources. Originating in industrial fabrication process, prototyping can be adapted by librarians to examine changes made to library services, amenities, and resources. They offer a cost-effective way of trying something new and needed, to ensure that patron needs are met. This article modifies prototyping into a five-step process and reviews five examples where the Lee Library used prototyping to inform library decisions to inform the development of library services, amenities, processes, and resources to better serve its patrons.
De Novo Assembly Of A High-Quality Reference Genome For The Horned Lark (Eremophila Alpestris), Nicholas A. Mason, Paulo Pulgarin, Carlos Daniel Cadena, Irby J. Lovette
De Novo Assembly Of A High-Quality Reference Genome For The Horned Lark (Eremophila Alpestris), Nicholas A. Mason, Paulo Pulgarin, Carlos Daniel Cadena, Irby J. Lovette
Faculty Publications
Copyright © 2020 Mason et al. The Horned Lark (Eremophila alpestris) is a small songbird that exhibits remarkable geographic variation in appearance and habitat across an expansive distribution. While E. alpestris has been the focus of many ecological and evolutionary studies, we still lack a highly contiguous genome assembly for the Horned Lark and related taxa (Alaudidae). Here, we present CLO_EAlp_1.0, a highly contiguous assembly for E. alpestris generated from a blood sample of a wild, male bird captured in the Altiplano Cundiboyacense of Colombia. By combining short-insert and mate-pair libraries with the ALLPATHS-LG genome assembly pipeline, we generated a …
Mitochondrial Pyruvate Carriers Are Not Required For Adipogenesis But Are Regulated By High-Fat Feeding In Brown Adipose Tissue, Jasmine A. Burrell, Allison J. Richard, William T. King, Jacqueline M. Stephens
Mitochondrial Pyruvate Carriers Are Not Required For Adipogenesis But Are Regulated By High-Fat Feeding In Brown Adipose Tissue, Jasmine A. Burrell, Allison J. Richard, William T. King, Jacqueline M. Stephens
Faculty Publications
© 2020 The Obesity Society. Objective: The objectives of this study were to assess the role of mitochondrial pyruvate carriers (MPCs) in adipocyte development in vitro and determine whether MPCs are regulated in vivo by high-fat feeding in male and female C57BL/6J mice. Methods: This study utilized small interfering RNA-mediated knockdown to assess the requirement of MPC1 for adipogenesis in the 3T3-L1 model system. Treatment with UK-5099, a potent pharmacological MPC inhibitor, was also used to assess the loss of MPC activity. Western blot analysis was performed on adipose tissue samples from mice on a low-fat diet or a high-fat …