Digital Commons Network^™

Cycling Phosphorus And Nitrogen Through Cropping Systems In An Intensive Dairy Production Region, April B. Leytem, Paula Williams, Shan Zuidema, Audrey Martinez, Yen Leng Chong, Alyssa Vincent, Aaron Vincent, Daniel Cronan, Andrew Kliskey, J. D. Wulfhorst, Lilian Alessa, David Bjorneberg

Faculty Publications

As pressure on the dairy industry to reduce its environmental impact increases, efficient recycling of manure nutrients through local cropping systems becomes crucial. The aim of this study was to calculate annual nitrogen (N) and phosphorus (P) budgets in six counties located in the Magic Valley, Idaho and estimate what distance manure would need to be transported to be in balance with crop nutrient demand given current dairy cattle populations and cropping systems. Our analysis suggests that crop N needs will not be met solely by manure, and synthetic fertilizer will need to be applied. However, to balance P with …

Fungal Community Response To Long-Term Soil Warming With Potential Implications For Soil Carbon Dynamics, Gregory J. Pec, Linda T. A. Van Diepen, Melissa A. Knorr, A. Stuart Grandy, Jerry M. Melillo, Kristen M. Deangelis, Jeffrey L. Blanchard, Serita D. Frey

Faculty Publications

The direction and magnitude of climate warming effects on ecosystem processes such as carbon cycling remain uncertain. Soil fungi are central to these processes due to their roles as decomposers of soil organic matter, as mycorrhizal symbionts, and as determinants of plant diversity. Yet despite their importance to ecosystem functioning, we lack a clear understanding of the long-term response of soil fungal communities to warming. Toward this goal, we characterized soil fungal communities in two replicated soil warming experiments at the Harvard Forest (Petersham, Massachusetts, USA) which had experienced 5°C above ambient soil temperatures for 5 and 20 yr at …

Management Intensive Grazing On New England Dairy Farms Enhances Soil Nitrogen Stocks And Elevates Soil Nitrous Oxide Emissions Without Increasing Soil Carbon, Alexandra R. Contosta, Kyle A. Arndt, Eleanor E. Campbell, A. Stuart Grandy, Apryl L. Perry, Ruth K. Varner

Faculty Publications

Management intensive grazing (MIG), also known as rotational grazing or multi-paddock grazing, is purported to sequester carbon (C) in soils compared to other agricultural management systems. Prior research examining the potential for MIG to enhance soil C has been inconclusive, and past investigations have not addressed whether higher nitrous oxide (N2O) emissions may accompany increases in soil C stocks. Here we examined linkages among MIG, soil C accumulation, and N2O emissions in cool-season, organic pastures of the northeastern United States. We found that pastures under MIG increased soil C concentrations by 11% from 0–15 cm depth but that soil C …

Model For Quantifying The Quality Of Secure Service, Paul M. Simon, Scott R. Graham, Christopher Talbot, Micah J. Hayden

Faculty Publications

Although not common today, communications networks could adjust security postures based on changing mission security requirements, environmental conditions, or adversarial capability, through the coordinated use of multiple channels. This will require the ability to measure the security of communications networks in a meaningful way. To address this need, in this paper, we introduce the Quality of Secure Service (QoSS) model, a methodology to evaluate how well a system meets its security requirements. This construct enables a repeatable and quantifiable measure of security in a single- or multi-channel network under static configurations. In this approach, the quantification of security is based …

The Effect Of Phragmites Australis Dieback On Channel Sedimentation In The Mississippi River Delta: A Conceptual Modeling Study, Kelin Hu, Ehab Meselhe, J. Andrew Nyman

Faculty Publications

Phragmites australis is a globally distributed wetland plant. At the mouth of the Mississippi River, P. australis on natural levees of the network of distributary channels appears to increase the flow in the deep draft navigation channel, which, in turn, may reduce the sedimentation and benefit the navigation dredging. For several years, P. australis has been dying in the Mississippi River’s Bird’s Foot Delta, which appears to be shortening the distributary channels and increasing the lateral flow from the remaining portions. A conceptual model based on D-FLOW FM was applied to calculate channel sedimentation in a series of idealized deltaic …

Ramipril Blunts Glycerol-Induced Acute Renal Failure In Rats Through Its Antiapoptosis, Anti-Inflammatory, Antioxidant, And Renin-Inhibiting Properties, Adeolu Alex Adedapo, Ehizogie Ruth Osaretin, Olufunke Olubunmi Falayi, Ademola Adetokunbo Oyagbemi, Blessing Seun Ogunpolu, Temidayo Olutayo Omobowale, Oluwafemi Omoniyi Oguntibeju, Momoh Audu Yakubu

Faculty Publications

Acute kidney injury (AKI) is a malady with a sudden onset resulting in buildup of waste matters in the body, but a specific cure hasn't been found as a lasting solution to AKI. In this study, ramipril was evaluated for its potential therapy in glycerol-induced AKI in rats. Twenty animals were divided into four groups of five animals each. Group I was the control while group II was given glycerol on day 8 only, groups III and IV were administered with pioglitazone (reference drug) and ramipril for seven days respectively and on day 8 received glycerol. On the ninth day, …

Time Lags: Insights From The U.S. Long Term Ecological Research Network, Edward B. Rastetter, Mark D. Ohman, Katherine J. Elliott, J. S. Rehage, Victor H. Rivera-Monroy, R. E. Boucek, Edward Castañeda-Moya, Tess M. Danielson, Laura Gough, Peter M. Groffman, C. Rhett Jackson, Chelcy Ford Miniat, Gaius R. Shaver

Faculty Publications

Ecosystems across the United States are changing in complex ways that are difficult to predict. Coordinated long-term research and analysis are required to assess how these changes will affect a diverse array of ecosystem services. This paper is part of a series that is a product of a synthesis effort of the U.S. National Science Foundation’s Long Term Ecological Research (LTER) network. This effort revealed that each LTER site had at least one compelling scientific case study about “what their site would look like” in 50 or 100 yr. As the site results were prepared, themes emerged, and the case …

An Efficient Alternative To The Cdc Gravid Trap For Southern House Mosquito (Diptera: Culicidae) Surveillance, Timothy D. Mcnamara, Thomas A. O'Shea-Wheller, Nicholas Delisi, Emily Dugas, Kevin A. Caillouet, Randy Vaeth, Dennis Wallette, Kristen Healy

Faculty Publications

West Nile virus (WNV) is the most prevalent arbovirus found throughout the United States. Surveillance of surface breeding Culex vectors involved in WNV transmission is primarily conducted using CDC Gravid traps. However, anecdotal claims from mosquito abatement districts in Louisiana assert that other trap types may be more suited to WNV surveillance. To test the validity of these assertions, we conducted a series of trapping trials and WNV surveillance over 3 yr to compare the efficacy of multiple trap types. First, we compared the CDC Gravid trap, CO2-baited New Standard Miniature Blacklight traps, and CO2-baited CDC light traps with either …

Elevated Incidences Of Antimicrobial Resistance And Multidrug Resistance In The Maumee River (Ohio, Usa), A Major Tributary Of Lake Erie, Maitreyee Mukherjee, Leah Marie, Cheyenne Liles, Nadia Mustafa, George Bullerjahn, Terry J. Gentry, John P. Brooks

Faculty Publications

Maumee River, the major tributary in the western basin of Lake Erie, serves as one of major sources of freshwater in the area, supplying potable, recreational, and industrial water. In this study we collected water samples from four sites in the Maumee River Bay between 2016–2017 and E. coli was isolated, enumerated, and analyzed for antimicrobial resistance (AMR) and multidrug resistance (MDR). Strikingly, 95% of the total isolates were found to be resistant to at least one antibiotic. A very high resistance to the drugs cephalothin (95.3%), ampicillin (38.3%), tetracycline (8.8%), gentamicin (8.2%), ciprofloxacin (4.2%), cefoperazone (4%), and sulfamethoxazole (1.5%) …

Heavy Metal-Resistant Filamentous Fungi As Potential Mercury Bioremediators, Cristina L. Văcar, Eniko Covaci, Somsubhra Chakraborty, Bin Li, David Weindorf, Tiberiu Frentiu, Marcel Pârvu, Dorina Podar

Faculty Publications

No abstract provided.

Conceptus Metabolomic Profiling Reveals Stage-Specific Phenotypes Leading Up To Pregnancy Recognition In Cattle†, Constantine A. Simintiras, José M. Sánchez, Michael Mcdonald, Elena O'Callaghan, Ahmed A. Aburima, Patrick Lonergan

Faculty Publications

Reproductive efficiency in livestock is a major driver of sustainable food production. The poorly understood process of ruminant conceptus elongation (a) prerequisites maternal pregnancy recognition, (b) is essential to successful pregnancy establishment, and (c) coincides with a period of significant conceptus mortality. Conceptuses at five key developmental stages between Days 8-16 were recovered and cultured in vitro for 6 h prior to conditioned media analysis by untargeted ultrahigh-performance liquid chromatography tandem mass spectroscopy. This global temporal biochemical interrogation of the ex situ bovine conceptus unearths two antithetical stage-specific metabolic phenotypes during tubular (metabolically retentive) vs. filamentous (secretory) development. Moreover, the …

Polycyclic Aromatic Hydrocarbon-Dna Adducts In Gulf Of Mexico Sperm Whale Skin Biopsies Collected In 2012, Miriam C. Poirier, Letizia Marsili, Maria Cristina Fossi, Céline A.J. Godard-Codding, Elena E. Hernandez-Ramon, Nancy Si, Kathyayini V. Divi, Rao L. Divi, Iain Kerr, John Pierce Wise, John Pierce Wise, Catherine F. Wise, Sandra S. Wise, Abou El Makarim Aboueissa, James T.F. Wise

Faculty Publications

The northern Gulf of Mexico has a long history of polycyclic aromatic hydrocarbon (PAH) contamination from anthropogenic activities, natural oil seepages, and the 2010 Deepwater Horizon explosion and oil spill. The continental shelf of the same area is a known breeding ground for sperm whales (Physeter macrocephalus). To evaluate PAH-DNA damage, a biomarker for potential cancer risk, we compared skin biopsies collected from Gulf of Mexico sperm whales in 2012 with skin biopsies collected from sperm whales in areas of the Pacific Ocean in 1999-2001. All samples were obtained by crossbow and comprised both epidermis and subcutaneous blubber. To evaluate …

Circadian Rhythms In Legumes: What Do We Know And What Else Should We Explore?, Hazel Marie Kugan, Nur Ardiyana Rejab, Nurul Amylia Sahruzaini, Jennifer Ann Harikrishna, Niranjan Baisakh, Acga Cheng

Faculty Publications

The natural timing devices of organisms, commonly known as biological clocks, are composed of specific complex folding molecules that interact to regulate the circadian rhythms. Circadian rhythms, the changes or processes that follow a 24‐h light–dark cycle, while endogenously programmed, are also influenced by environmental factors, especially in sessile organisms such as plants, which can impact ecosystems and crop productivity. Current knowledge of plant clocks emanates primarily from research on Arabidopsis, which identified the main components of the circadian gene regulation network. Nonetheless, there remain critical knowledge gaps related to the molecular components of circadian rhythms in important crop groups, …

Genome-Wide Association Study Reveals Genomic Regions Associated With Fusarium Wilt Resistance In Common Bean, Jean Fausto De Carvalho Paulino, Caléo Panhoca De Almeida, César Júnior Bueno, Qijian Song, Roberto Fritsche-Neto, Sérgio Augusto Morais Carbonell, Alisson Fernando Chiorato, Luciana Lasry Benchimol-Reis

Faculty Publications

Fusarium wilt (Fusarium oxysporum f. sp. phaseoli, Fop) is one of the main fungal soil diseases in common bean. The aim of the present study was to identify genomic regions associated with Fop resistance through genome-wide association studies (GWAS) in a Mesoamerican Diversity Panel (MDP) and to identify potential common bean sources of Fop’s resistance. The MDP was genotyped with BARCBean6K_3BeadChip and evaluated for Fop resistance with two different monosporic strains using the root-dip method. Disease severity rating (DSR) and the area under the disease progress curve (AUDPC), at 21 days after inoculation (DAI), were used for GWAS performed with …

Insecticidal Rna Interference, Thinking Beyond Long Dsrna, Alex S. Flynt

Faculty Publications

Over 20 years ago double-stranded RNA (dsRNA) was described as the trigger of RNAi interference (RNAi)-based gene silencing. This paradigm has held since, especially for insect biopesticide technologies where dsRNAs, similar to those described in 1998, are used to inhibit gene expression. In the intervening years, investigation of RNAi pathways has revealed the small RNA effectors of RNAi are diverse and rapidly evolving. The rich biology of insect small RNAs suggests potential to use multiple RNAi modes for manipulating gene expression. By exploiting different RNAi pathways, the menu of options for pest control can be expanded and could lead to …

Teaching Leadership In American Law Schools: Why The Pushback?, Martin H. Brinkley

Faculty Publications

In September 2020, I participated in a panel discussion with several other deans at Baylor Law School’s 2020: Vision for Leadership Conference. The subject was “Leadership Programming in Law Schools.”

My assignment was to account for why teaching leadership might meet with resistance from inside law schools, despite widespread agreement that lawyer-leaders have always been and are always likely be critical to the survival of American democracy, as well as our fellow citizens’ hopes of living meaningful, satisfying lives.

This essay endeavors to memorialize and expand on the views I expressed on the panel.

Recent Advances In Understanding Tick And Rickettsiae Interactions, Shahid Karim, Deepak Kumar, Khemraj Budachetri

Faculty Publications

Ticks are haematophagous arthropods with unique molecular mechanisms for digesting host blood meal while acting as vectors for various pathogens of public health significance. The tick's pharmacologically active saliva plays a fundamental role in modulating the host's immune system for several days to weeks, depending on the tick species. The vector tick has also developed sophisticated molecular mechanisms to serve as a competent vector for pathogens, including the spotted fever group (SFG) rickettsiae. Evidence is still inadequate concerning tick–rickettsiae–host interactions and saliva-assisted transmission of the pathogen to the mammalian host. Rickettsia parkeri, of the SFG rickettsia, can cause a …

Vr-Caps: A Virtual Environment For Capsule Endoscopy, Kağan İncetan, Ibrahim Omer Celik, Abdulhamid Obeid, Guliz Irem Gokceler, Kutsev Bengisu Ozyoruk, Yasin Almalioglu, Richard J. Chen, Faisal Mahmood, Hunter Gilbert, Nicholas J. Durr, Mehmet Turan

Faculty Publications

Current capsule endoscopes and next-generation robotic capsules for diagnosis and treatment of gastrointestinal diseases are complex cyber-physical platforms that must orchestrate complex software and hardware functions. The desired tasks for these systems include visual localization, depth estimation, 3D mapping, disease detection and segmentation, automated navigation, active control, path realization and optional therapeutic modules such as targeted drug delivery and biopsy sampling. Data-driven algorithms promise to enable many advanced functionalities for capsule endoscopes, but real-world data is challenging to obtain. Physically-realistic simulations providing synthetic data have emerged as a solution to the development of data-driven algorithms. In this work, we present …

Roboethics In Covid-19: A Case Study In Dentistry, Wendy C. Birmingham, Yaser Maddahi, Maryam Kalvandi, Sofya Langman, Nicole Capicotto, Kourosh Zareinia

Faculty Publications

The COVID-19 pandemic has caused dramatic effects on the healthcare system, businesses, and education. In many countries, businesses were shut down, universities and schools had to cancel in-person classes, and many workers had to work remotely and socially distance in order to prevent the spread of the virus. These measures opened the door for technologies such as robotics and artificial intelligence to play an important role in minimizing the negative effects of such closures. There have been many efforts in the design and development of robotic systems for applications such as disinfection and eldercare. Healthcare education has seen a lot …

Association Between Dietary Inflammatory Index, Dietary Patterns, Plant-Based Dietary Index And The Risk Of Obesity, Yoko B. Wang, Nitin Shivappa, James R. Hébert Scd, Amanda J. Page, Yohannes Adama Melaku

Faculty Publications

Evidence on the association between various dietary constructs and obesity risk is limited. This study aims to investigate the longitudinal relationship between different diet indices and dietary patterns with the risk of obesity. Non-obese participants (n = 787) in the North West Adelaide Health Study were followed from 2010 to 2015. The dietary inflammatory index (DII®), plant-based dietary index (PDI) and factor-derived dietary pattern scores were computed based on food frequency questionnaire data. We found the incidence of obesity was 7.62% at the 5-year follow up. In the adjusted model, results from multivariable log-binomial logistic regression showed that a prudent …

Relationship Among Combat Experience, Veteran Pathology, And Pathology Of Veterans’ Intimate Partners: Factors Predicting The Pathology Of Veterans And Their Intimate Partners, Edwin A. Brennan, Nancy Carbonell, Jimmy Kijai, Dennis Waite

Faculty Publications

Introduction: Military members and their families have been part of the Global War on Terrorism since the September 11, 2001, terrorist attacks on the United States. As a result, higher levels of pathology — such as posttraumatic stress disorder, generalized anxiety disorder, and depression — are being seen. No known studies have addressed the concept of resonating pathology between combat Veterans and their intimate partners. Resonating pathology, for the purpose of this study, is when the combat Veteran and their intimate partner demonstrate the same pathology at similar levels. Methods: Veterans and their intimate partners from across the United States …

A Scapegoat Theory Of Bivens, Katherine Mims Crocker

Faculty Publications

Some scapegoats are innocent. Some warrant blame, but not the amount they are made to bear. Either way, scapegoating can allow in-groups to sidestep social problems by casting blame onto out-groups instead of confronting such problems--and the in-groups' complicity in perpetuating them--directly.

This Essay suggests that it may be productive to view the Bivens regime's rise as countering various exercises in scapegoating and its retrenchment as constituting an exercise in scapegoating. The earlier cases can be seen as responding to social structures that have scapegoated racial, economic, and other groups through overaggressive policing, mass incarceration, and inequitable government conduct more …

Comparable Response Of Wild Rodent Gut Microbiome To Anthropogenic Habitat Contamination, Anton Lavrinienko, Ann Hämäläinen, Rasmus Hindstrom, Eugene Tukalenko, Zbyszek Boratynski, Kati Kivisaari, Timothy Mousseau, Phillip C. Watts, Tapio Mappes

Faculty Publications

Species identity is thought to dominate over environment in shaping wild rodent gut microbiota, but it remains unknown whether the responses of host gut microbiota to shared anthropogenic habitat impacts are species-specific or if the general gut microbiota response is similar across host species. Here, we compare the influence of exposure to radionuclide contamination on the gut microbiota of four wild mouse species: Apodemus flavicollis, A. sylvaticus, A. speciosus and A. argenteus. Building on the evidence that radiation impacts bank vole (Myodes glareolus) gut microbiota, we hypothesized that radiation exposure has a general impact on rodent gut microbiota. Because we …

Potential Roles Of Endoplasmic Reticulum Stress And Cellular Proteins Implicated In Diabesity, Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Ismaeel Yunusa, Aishatu Shehu, Lukman Mustapha, Yusuf Wada, Mubarak Hussaini Ahmad, Wan Amir Wan Ahmad, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar

Faculty Publications

The role of the endoplasmic reticulum (ER) has evolved from protein synthesis, processing, and other secretory pathways to forming a foundation for lipid biosynthesis and other metabolic functions. Maintaining ER homeostasis is essential for normal cellular function and survival. An imbalance in the ER implied stressful conditions such as metabolic distress, which activates a protective process called unfolded protein response (UPR). This response is activated through some canonical branches of ER stress, i.e., the protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1α (IRE1α), and activating transcription factor 6 (ATF6). Therefore, chronic hyperglycemia, hyperinsulinemia, increased proinflammatory …

The Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome By Downregulating Mirna That Target Inflammatory Pathways, Muthanna Sultan, Hasan Alghetaa, Amirah Mohammed, Osama A. Abdulla, Paul J. Wisniewski, Narendra Singh, Prakash Nagarkatti, Mitzi Nagarkatti

Faculty Publications

Acute respiratory distress syndrome (ARDS) is defined as a type of respiratory failure that is caused by a variety of insults such as pneumonia, sepsis, trauma and certain viral infections. In this study, we investigated the effect of an endocannabinoid, anandamide (AEA), on ARDS induced in the mouse by Staphylococcus Enterotoxin B (SEB). Administration of a single intranasal dose of SEB in mice and treated with exogenous AEA at a dose of 40 mg/kg body weight led to the amelioration of ARDS in mice. Clinically, plethysmography results indicated that there was an improvement in lung function after AEA treatment accompanied …

Root Exudates Alter The Expression Of Diverse Metabolic, Transport, Regulatory, And Stress Response Genes In Rhizosphere Pseudomonas, Olga V. Mavrodi, Janiece R. Mcwilliams, Jacob O. Peter, Anna Berim, Karl A. Hassan, Liam D.H. Elbourne, Melissa K. Letourneau, David R. Gang, Ian T. Paulsen, David M. Weller, Linda S. Thomashow, Alex S. Flynt, Dmitri V. Mavrodi

Faculty Publications

Plants live in association with microorganisms that positively influence plant development, vigor, and fitness in response to pathogens and abiotic stressors. The bulk of the plant microbiome is concentrated belowground at the plant root-soil interface. Plant roots secrete carbon-rich rhizodeposits containing primary and secondary low molecular weight metabolites, lysates, and mucilages. These exudates provide nutrients for soil microorganisms and modulate their affinity to host plants, but molecular details of this process are largely unresolved. We addressed this gap by focusing on the molecular dialog between eight well-characterized beneficial strains of the Pseudomonas fluorescens group and Brachypodium distachyon, a model …

A Genetic Screen Identifies New Steps In Oocyte Maturation That Enhance Proteostasis In The Immortal Germ Lineage, M Samaddar, J Goudeau, M Sanchez, D H. Hall, M Samaddar, M Ingaramo, C Kenyon

Faculty Publications

Somatic cells age and die, but the germ-cell lineage is immortal. In Caenorhabditis elegans, germline immortality involves proteostasis renewal at the beginning of each new generation, when oocyte maturation signals from sperm trigger the clearance of carbonylated proteins and protein aggregates. Here, we explore the cell biology of this proteostasis renewal in the context of a whole-genome RNAi screen. Oocyte maturation signals are known to trigger protein-aggregate removal via lysosome acidification. Our findings suggest that lysosomes are acidified as a consequence of changes in endoplasmic reticulum activity that permit assembly of the lysosomal V-ATPase, which in turn allows lysosomes to …

Capture And Metabolomic Analysis Of The Human Endometrial Epithelial Organoid Secretome, Constantine A. Simintiras, Pramod Dhakal, Chaman Ranjit, Harriet C. Fitzgerald, Ahmed Z. Balboula, Thomas E. Spencer

Faculty Publications

Suboptimal uterine fluid (UF) composition can lead to pregnancy loss and likely contributes to offspring susceptibility to chronic adult-onset disorders. However, our understanding of the biochemical composition and mechanisms underpinning UF formation and regulation remain elusive, particularly in humans. To address this challenge, we developed a high-throughput method for intraorganoid fluid (IOF) isolation from human endometrial epithelial organoids. The IOF is biochemically distinct to the extraorganoid fluid (EOF) and cell culture medium as evidenced by the exclusive presence of 17 metabolites in IOF. Similarly, 69 metabolites were unique to EOF, showing asymmetrical apical and basolateral secretion by the in vitro …

Gastrointestinal Microenvironment And The Gut-Lung Axis In The Immune Responses Of Severe Covid-19, Yun Yang, Weishan Huang, Yubo Fan, Guo-Qiang Chen

Faculty Publications

The global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented threat to the human health. A close association of the digestive tract is implied by the high frequency of gastrointestinal syndromes among COVID-19 patients. A better understanding of the role of intestinal microenvironment in COVID-19 immunopathology will be helpful to improve the control of COVID-19 associated morbidity and mortality. This review summarizes the immune responses associated with the severity of COVID-19, the current evidence of SARS-CoV-2 intestinal tropism, and the potential involvement of gut microenvironment in COVID-19 severity. Additionally, we …

Early Rearing Conditions Affect Monoamine Metabolite Levels During Baseline And Periods Of Social Separation Stress: A Non-Human Primate Model (Macaca Mulatta), Elizabeth K. Wood, Natalia Gabrielle, Jacob Hunter, Andrea N. Skowbo, Melanie L. Schwandt, Stephen G. Lindell, Christina S. Barr, Stephen J. Suomi, James Dee Higley

Faculty Publications

A variety of studies show that parental absence early in life leads to deleterious effects on the developing CNS. This is thought to be largely because evolutionary-dependent stimuli are necessary for the appropriate postnatal development of the young brain, an effect sometimes termed the “experience-expectant brain,” with parents providing the necessary input for normative synaptic connections to develop and appropriate neuronal survival to occur. Principal among CNS systems affected by parental input are the monoamine systems. In the present study, N = 434 rhesus monkeys (233 males, 201 females) were reared in one of two conditions: as mother-reared controls (MR; …