Digital Commons Network^™

Influencing Perceptions Of Stem Through The Best Stem Books List, Scott Bartholomew, Alexia Seymour

Faculty Publications

One day, while discussing engineering and science as potential career options with a female student, we opened a search engine and typed in “engineer” and “scientist.” However, on the first pages of image results, only one female appeared for engineering and only a few females appeared for “scientist” (see Figure 1). This disparity was disturbing—if this student never saw another person like her filling careers in STEM fields, would she ever “picture herself” in those fields?

An Evidence-Based Review Of The Pathophysiology, Treatment, And Prevention Of Exercise-Associated Muscle Cramps, Kevin C. Miller, Brendon P. Mcdermott, Susan W. Yeargin, Aidan Fiol, Martin P. Schwellnus

Faculty Publications

Exercise-associated muscle cramps (EAMCs) are common and frustrating for athletes and the physically active. We critically appraised the EAMC literature to provide evidence based treatment and prevention recommendations. Although the pathophysiology of EAMCs appears controversial, recent evidence suggests that EAMCs are due to a confluence of unique intrinsic and extrinsic factors rather than a singular cause. The treatment of acute EAMCs continues to include self-applied or clinician-guided gentle static stretching until symptoms abate. Once the painful EAMCs are alleviated, the clinician can continue treatment on the sidelines by focusing on patient-specific risk factors that may have contributed to the onset …

The Young Age And Plant-Based Diet Hypothesis For Low Sars-Cov-2 Infection And Covid-19 Pandemic In Sub-Saharan Africa, J N. Losso, M N. Losso, M Toc, J N. Inungu, J N. Losso

Faculty Publications

Since the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease-19 (COVID-19), in December 2019, the infection has spread around the globe. Some of the risk factors include social distancing, mask wearing, hand washing with soap, obesity, diabetes, hypertension, asthma, cardiovascular disease, and dysbiosis. Evidence has shown the incidence of total infection and death rates to be lower in sub-Saharan Africa when compared with North Africa, Europe and North America and many other parts of the world. The higher the metabolic syndrome rate, the higher the risk of SARS-CoV-2 infection. Africa has a lower …

A Nationwide Population-Based Study On The Association Between Land Transport Accident And Peripheral Vestibular Disorders, Herng-Ching Lin, Sudha Xirasagar Mbbs,Ph.D., Chia-Hui Wang, Yen-Fu Cheng, Tsai-Ching Liu, Tzong-Hann Yang

Faculty Publications

This case-control study aimed to investigate the association of peripheral vestibular disorders (PVD) with subsequent land transport accidents. Data for this study were obtained from Taiwan's National Health Insurance (NHI) dataset. We retrieved 8704 subjects who were newly found to have land transport accidents as cases. Their diagnosis date was used as their index date. Controls were identified by propensity score matching (one per case, n = 8704 controls) from the NHI dataset with their index date being the date of their first health service claim in 2017. Multiple logistic regressions were performed to calculate the prior PVD odds ratio …

Microglial Implications In Sars-Cov-2 Infection And Covid-19: Lessons From Viral Rna Neurotropism And Possible Relevance To Parkinson's Disease, Ifeoluwa O. Awogbindin, Benneth Ben-Azu, Babatunde A. Olusola, Elizabeth T. Akinluyi, Philip A. Adeniyi, T. Di Paolo, Marie-Eve Tremblay

Faculty Publications

Since December 2019, humankind has been experiencing a ravaging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, the second coronavirus pandemic in a decade after the Middle East respiratory syndrome coronavirus (MERS-CoV) disease in 2012. Infection with SARS-CoV-2 results in Coronavirus disease 2019 (COVID-19), which is responsible for over 3.1 million deaths worldwide. With the emergence of a second and a third wave of infection across the globe, and the rising record of multiple reinfections and relapses, SARS-CoV-2 infection shows no sign of abating. In addition, it is now evident that SARS-CoV-2 infection presents with neurological symptoms that include early …

A Monte Carlo Simulation Of A Protein (Cove) In A Matrix Of Random Barriers, R. B. Pandey

Faculty Publications

Monte Carlo simulations are performed to study structure and dynamics of a protein CoVE in random media generated by a random distribution of barriers at concentration c with a coarse-grained model in its native (low temperature) and denatured (high temperature) phase. The stochastic dynamics of the protein is diffusive in denature phase at low c, it slows down on increasing c and stops moving beyond a threshold (c_th ≈ 0.10). In native phase, the protein moves extremely slow at low c but speeds up on further increasing c in a characteristic range (c =0.10–0.20) before …

Application Of Compositional Data Analysis To Determine The Effects Of Heating Mode, Moisture Status And Plant Species On Pyrolysates, David R. Weise, Thomas H. Fletcher, Mohammad-Saeed Safdari, Elham Amini, Javier Palarea-Albaladejo

Faculty Publications

Pyrolysate gas mixtures are multivariate and relative in nature. Statistical techniques applied to these data generally ignore their relative nature. Published data for permanent gases (CO, CO2, H2, CH4) and tars produced by pyrolysing 15 wildland fuels were reanalysed using compositional data analysis techniques. Mass and mole fractions were compositionally equivalent. Plant species, moisture status and heating mode effects on compositional balances formed from subsets of pyrolysates were tested. Plant species affected the amount of phenol, primary and secondary/tertiary tars relative to permanent gases and relative amounts of single- and multi-ring compounds. Plant moisture status affected the amount of CO …

Framing Sports' Corporate Social Responsibility: Us Women's Vs Men's Soccer Leagues, David Painter, Brittani Sahm, Paul Schattschneider

Faculty Publications

Purpose – This investigation’s purpose is to compare coverage of the corporate social responsibility (CSR) behaviors of the National Women’s Soccer League (NWSL) and Major League Soccer (MLS). The goals are (1) to extend CSR analyses beyond organizational reports and (2) to compare coverage of professional sports teams’ CSR behaviors across genders.

Design/methodology/approach – Specifically, this quantitative content analysis compared local newspaper coverage of the socially responsible behaviors of the three NWSL and MLS teams owned and operated by the same organizations in Portland, Houston and Orlando.

Findings – The NWSL teams received significantly less and more negative coverage than …

A Systematic Literature Review Of Sexual Harassment Studies With Text Mining, Amir Karami, Melek Yildiz Spinel, Nicole White, Kayla Ford, Suzanne Swan

Faculty Publications

Sexual harassment has been the topic of thousands of research articles in the 20th and 21st centuries. Several review papers have been developed to synthesize the literature about sexual harassment. While traditional literature review studies provide valuable insights, these studies have some limitations including analyzing a limited number of papers, being time-consuming and labor-intensive, focusing on a few topics, and lacking temporal trend analysis. To address these limitations, this paper employs both computational and qualitative approaches to identify major research topics, explore temporal trends of sexual harassment topics over the past few decades, and point to future possible directions in …

S-Equol Mitigates Motivational Deficits And Dysregulation Associated With Hiv-1, Kristen A. Mclaurin, Sarah J. Bertrand, Jessica M. Illenberger, Steven B. Harrod, Charles F. Mactutus, Rosemarie M. Booze

Faculty Publications

Motivational deficits (e.g., apathy) and dysregulation (e.g., addiction) in HIV-1 seropositive individuals, despite treatment with combination antiretroviral therapy, necessitates the development of innovative adjunctive therapeutics. S-Equol (SE), a selective estrogen receptor beta agonist, has been implicated as a neuroprotective and/or neurorestorative therapeutic for HIV-1 associated neurocognitive disorders (HAND); its therapeutic utility for motivational alterations, however, has yet to be systematically evaluated. Thus, HIV-1 transgenic (Tg) and control animals were treated with either a daily oral dose of SE (0.2 mg) or vehicle and assessed in a series of tasks to evaluate goal-directed and drug-seeking behavior. First, at the genotypic level, …

Biologically-Based Mathematical Modeling Of Tumor Vasculature And Angiogenesis Via Time-Resolved Imaging Data, David A. Hormuth, Caleb M. Phillips, Chengyue Wu, Ernesto A.B.F. Lima, Guillermo Lorenzo, Prashant K. Jha, Angela M. Jarrett, J. Tinsley Oden, Thomas E. Yankeelov

Faculty Publications

Tumor-associated vasculature is responsible for the delivery of nutrients, removal of waste, and allowing growth beyond 2–3 mm3. Additionally, the vascular network, which is changing in both space and time, fundamentally influences tumor response to both systemic and radiation therapy. Thus, a robust understanding of vascular dynamics is necessary to accurately predict tumor growth, as well as establish optimal treatment protocols to achieve optimal tumor control. Such a goal requires the intimate integration of both theory and experiment. Quantitative and time-resolved imaging methods have emerged as technologies able to visualize and characterize tumor vascular properties before and during therapy at …

Plague Vaccines: New Developments In An Ongoing Search, Jason A. Rosenzweig, Emily K. Hendrix, Ashok K. Chopra

Faculty Publications

Abstract: As the reality of pandemic threats challenges humanity, exemplified during the ongoing SARS-CoV-2 infections, the development of vaccines targeting these etiological agents of disease has become increasingly critical. Of paramount concern are novel and reemerging pathogens that could trigger such events, including the plague bacterium Yersinia pestis. Y. pestis is responsible for more human deaths than any other known pathogen and exists globally in endemic regions of the world, including the four corners region and Northern California in the USA. Recent cases have been scattered throughout the world, including China and the USA, with serious outbreaks in Madagascar during …

Importance Of Low-Relief Nursery Habitat For Reef Fishes, Michael A. Dance, Jay R. Rooker, Richard J. Kline, Antonietta Quigg, Gregory R. Stunz, R. J.David Wells, Kirsten Lara, Jessica Lee, Bobbie Suarez

Faculty Publications

Coastal restoration projects to mitigate environmental impacts have increased global demand for sand resources. Unfortunately, these resources are often extracted from sand/shell banks on the inner continental shelf, resulting in significant alteration or loss of low-relief reefs in coastal oceans. Experimental reefs (oyster shell, limestone rubble, composite) were deployed in the western Gulf of Mexico to assess their potential value as nurseries for newly settled reef fishes. Occurrence, abundance, and species richness of juvenile fishes were significantly higher on all three types of low-relief reefs compared with unconsolidated sediment. Moreover, reefs served as nursery habitat for a range of reef …

Metabolic Effects Of Duodenojejunal Bypass Surgery In A Rat Model Of Type 1 Diabetes, R Vangoitsenhoven, R Wilson, G Sharma, S Punchai, R Vangoitsenhoven, D Froylich, A Mulya, P R. Schauer, S A. Brethauer, J P. Kirwan, N Sangwan, J M. Brown, A Aminian

Faculty Publications

Background Metabolic surgery has beneficial metabolic effects, including remission of type 2 diabetes. We hypothesized that duodenojejunal bypass (DJB) surgery can protect against development of type 1 diabetes (T1D) by enhancing regulation of cellular and molecular pathways that control glucose homeostasis. Methods BBDP/Wor rats, which are prone to develop spontaneous autoimmune T1D, underwent loop DJB (n = 15) or sham (n = 15) surgery at a median age of 41 days, before development of diabetes. At T1D diagnosis, a subcutaneous insulin pellet was implanted, oral glucose tolerance test was performed 21 days later, and tissues were collected 25 days after …

Brown Meets Green: Light And Nutrients Alter Detritivore Assimilation Of Microbial Nutrients From Leaf Litter, Taylor L. Price, Jennifer Harper, Steven N. Francoeur, Halvor M. Halvorson, Kevin A. Kuehn

Faculty Publications

In aquatic detrital-based food webs, research suggests that autotroph-heterotroph microbial interactions exert bottom-up controls on energy and nutrient transfer. To address this emerging topic, we investigated microbial responses to nutrient and light treatments during Liriodendron tulipifera litter decomposition and fed litter to the caddisfly larvae Pycnopsyche sp. We measured litter-associated algal, fungal, and bacterial biomass and production. Microbes were also labeled with ¹⁴C and ³³P to trace distinct microbial carbon (C) and phosphorus (P) supporting Pycnopsyche assimilation and incorporation (growth). Litter-associated algal and fungal production rates additively increased with higher nutrient and light availability. Incorporation of microbial P …

Effect Of Informed Conditions On Sensory Expectations And Actual Perceptions: A Case Of Chocolate Brownies Containing Edible-Cricket Protein, Cristhiam Gurdian, Damir Torrico, Bin Li, Georgianna Tuuri, Witoon Prinyawiwatkul

Faculty Publications

No abstract provided.

A Deep Learning Enhanced Novel Software Tool For Laryngeal Dynamics Analysis, Andreas M. Kist, Pablo Gómez, Denis Dubrovskiy, Patrick Schlegel, Melda Kunduk, Matthias Echternach, Rita Patel, Marion Semmler, Christopher Bohr, Stephan Dürr, Anne Schützenberger, Michael Döllinger

Faculty Publications

Purpose: High-speed videoendoscopy (HSV) is an emerging, but barely used, endoscopy technique in the clinic to assess and diagnose voice disorders because of the lack of dedicated software to analyze the data. HSV allows to quantify the vocal fold oscillations by segmenting the glottal area. This challenging task has been tackled by various studies; however, the proposed approaches are mostly limited and not suitable for daily clinical routine. Method: We developed a user-friendly software in C# that allows the editing, motion correction, segmentation, and quantitative analysis of HSV data. We further provide pretrained deep neural networks for fully automatic glottis …

A New Look For Tws Publications, Bret A. Collier, Paul R. Krausman, Merav Ben-David, Allison S. Cox, Anna C.S. Knipps, Jeffrey M. Levengood

Faculty Publications

The appearance of The Wildlife Society (TWS) publications (i.e., Wildlife Society Bulletin [WSB], Wildlife Monographs [WM], Journal of Wildlife Management [JWM]) has changed over the years. In 2021, a new journal design (NJD) will be implemented for TWS publications following months of discussion with Council and the journal editors. The scope of the articles and the mission of the journals will not change, but the format and layouts will be modified to simplify typesetting, assist with online reading, and provide a contemporary look for the publications of TWS.

Using A Global Food Environment Framework To Understand Relationships With Food Choice In Diverse Low- And Middle-Income Countries, Shilpa V. Constantinides, Christopher Turner, Edward A. Frongillo Jr., Shiva Bhandari, Ligia I. Reyes, Christine E. Blake

Faculty Publications

This study aimed to determine if the Turner et al. (2018) framework allows researchers to identify and study relationships between food environments and individual food choice in diverse contexts and if updates to the framework are warranted. We mapped evidence from 15 drivers of food choice projects to the framework, using thematic analysis to identify common drivers within the food environment across countries and emergent characteristics not listed in the framework. The framework contained breadth and depth of content necessary to identify common drivers – prices and affordability, availability, and vendor and product properties. Insights regarding common drivers and emergent …

Oocyte Specific Lncrna Variant Rose Influences Oocyte And Embryo Development, Rajan Iyyappan, Daria Aleshkina, Linkai Zhu, Zongliang Jiang, Veronika Kinterova, Andrej Susor

Faculty Publications

Fully grown mammalian oocytes store a large amount of RNA synthesized during the transcriptionally active growth stage. A large part of the stored RNA belongs to the long non-coding class which contain either transcriptional noise or important contributors to cellular physiology. Despite the expanding number of studies related to lncRNAs, their influence on oocyte physiology remains enigmatic. We found an oocyte specific antisense, long non-coding RNA, “Rose” (lncRNA in Oocyte Specifically Expressed) expressed in two variants containing two and three non-coding exons, respectively. Rose is localized in the nucleus of transcriptionally active oocyte and in embryo with polysomal occupancy in …

The Status Of Spotted Seatrout (Cynoscion Nebulosus) As A Technologically Feasible Species For U.S. Marine Aquaculture, Reginald Blaylock, Eric Saillant, Angelos Apeitos, David Abrego, Paul Cason, Robert Vega

Faculty Publications

Culture models and facilities for large-scale, commercial production of popular Gulf of Mexico species are unavailable. The spotted seatrout (Cynoscion nebulosus) is one of the most popular recreational fishes in the Gulf of Mexico. Seatrout culture techniques were adapted from red drum (Sciaenops ocellatus) protocols developed in the 1970s. Broodstock husbandry, spawning, and extensive pond rearing techniques using fertilized and bloomed brackish ponds were well-established by the 1980s. By 2018, approximately 80 million 25–30-day old seatrout had been produced, mainly for stock enhancement. Cannibalism and poor nutrition hindered intensive tank culture. Between 2005 and 2015, an …

Hyperpolarized Magnetic Resonance And Artificial Intelligence: Frontiers Of Imaging In Pancreatic Cancer, José S. Enriquez, Yan Chu, Shivanand Pudakalakatti, Kang Lin Hsieh, Duncan Salmon, Prasanta Dutta, Niki Zacharias Millward, Eugene Lurie, Steven Millward, Florencia Mcallister, Anirban Maitra, Subrata Sen, Ann Killary, Jian Zhang, Xiaoqian Jiang, Pratip K. Bhattacharya, Shayan Shams

Faculty Publications

Background: There is an unmet need for noninvasive imaging markers that can help identify the aggressive subtype(s) of pancreatic ductal adenocarcinoma (PDAC) at diagnosis and at an earlier time point, and evaluate the efficacy of therapy prior to tumor reduction. In the past few years, there have been two major developments with potential for a significant impact in establishing imaging biomarkers for PDAC and pancreatic cancer premalignancy: (1) hyperpolarized metabolic (HP)-magnetic resonance (MR), which increases the sensitivity of conventional MR by over 10,000-fold, enabling real-time metabolic measurements; and (2) applications of artificial intelligence (AI). Objective: Our objective of this review …

Toxoplasma Gondii, Suicidal Behavior, And Intermediate Phenotypes For Suicidal Behavior, Teodor T. Postolache, Abhishek Wadhawan, Dan Rujescu, Andrew J. Hoisington, Aline Dagdag, Enrique Baca-Garcia, Christopher A. Lowry, Olaoluwa O. Okusaga, Lisa A. Brenner

Faculty Publications

Within the general literature on infections and suicidal behavior, studies on Toxoplasma gondii ( T. gondii ) occupy a central position. This is related to the parasite's neurotropism, high prevalence of chronic infection, as well as specific and non-specific behavioral alterations in rodents that lead to increased risk taking, which are recapitulated in humans by T. gondii's associations with suicidal behavior, as well as trait impulsivity and aggression, mental illness and traffic accidents. This paper is a detailed review of the associations between T. gondii serology and suicidal behavior, a field of study that started 15 years ago with our …

First Data On Aquaculture Of The Tripletail, Lobotes Surinamensis, A Promising Candidate Species For U.S. Marine Aquaculture, Eric Saillant, Nicholas Adams, Jason T. Lemus, James S. Franks, Yonathan Zohar, John Stubblefield, Christopher Manley

Faculty Publications

The Tripletail, Lobotes surinamensis, is a warm-water pelagic fish that is increasingly targeted by U.S. anglers. The superior quality of Tripletail flesh coupled with the lack of domestic commercial fisheries stimulated interests to develop aquaculture of this species. In this work, photo-thermal conditioning of captive-held broodstocks promoted maturation in females, but spontaneous spawning was not observed. GnRHa slow-release implants induced ovulation in late vitellogenic females but fertility remained below 10% when GnRHa was administered alone. However, spawns with high fertility (up to 85%) were obtained when a dopamine antagonist was administered in conjunction with GnRHa implants indicating dopamine inhibition …

Spiritual Well-Being - A Proactive Resilience Component: Exploring Its Relationship With Practices, Themes, And Other Psychological Well-Being Factors During The Covid-19 Pandemic In Cism-Trained First Responders, Justine Jaeger, Harvey J. Burnett Jr., Kristen R. Witzel

Faculty Publications

Research suggests spiritual resilience may ameliorate the negative effects of exposure to traumatic events among disaster mental health first responders. Our study examined the relationship between spiritual wellness and associated resilience factors among four groups of first responders (law enforcement, fire services, emergency medical services and 911 dispatchers) trained in Critical Incident Stress Management (CISM) during a global pandemic. Utilizing a mixed methods-survey with transcendental phenomenological design, data was collected from 107 participants with membership in the International Critical Incident Stress Foundation (ICISF) or the Michigan Crisis Response Association (MCRA). Participants completed the Connor-Davidson Resilience Scale, Spiritual Well-Being Scale-Shortened Version, …

Current Approaches To The Treatment Of Post-Stroke Aphasia, Julius Fridriksson Ph.D., Argye Elizabeth Hillis

Faculty Publications

Aphasia, impairment of language after stroke or other neurological insult, is a common and often devastating condition that affects nearly every social activity and interaction. Behavioral speech and language therapy is the mainstay of treatment, although other interventions have been introduced to augment the effects of the behavioral therapy. In this narrative review, we discuss advances in aphasia therapy in the last 5 years and focus primarily on properly powered, randomized, controlled trials of both behavioral therapies and interventions to augment therapy for post-stroke aphasia. These trials include evaluation of behavioral therapies and computer-delivered language therapies. We also discuss outcome …

Increased Antimicrobial And Multidrug Resistance Downstream Of Wastewater Treatment Plants In An Urban Watershed, Maitreyee Mukherjee, Edward Laird, Terry J. Gentry, John P. Brooks, Raghupathy Karthikeyan

Faculty Publications

Development and spread of antimicrobial resistance (AMR) and multidrug resistance (MDR) through propagation of antibiotic resistance genes (ARG) in various environments is a global emerging public health concern. The role of wastewater treatment plants (WWTPs) as hot spots for the dissemination of AMR and MDR has been widely pointed out by the scientific community. In this study, we collected surface water samples from sites upstream and downstream of two WWTP discharge points in an urban watershed in the Bryan-College Station (BCS), Texas area, over a period of nine months. E. coli isolates were tested for resistance to ampicillin, tetracycline, sulfamethoxazole, …

Brief Overview Of Approaches And Challenges In New Antibiotic Development: A Focus On Drug Repurposing, Natalie K. Boyd, Chengwen Teng Pharm.D., Ph.D., Christopher R. Frei

Faculty Publications

Drug repurposing, or identifying new uses for existing drugs, has emerged as an alternative to traditional drug discovery processes involving de novo synthesis. Drugs that are currently approved or under development for non-antibiotic indications may possess antibiotic properties, and therefore may have repurposing potential, either alone or in combination with an antibiotic. They might also serve as “antibiotic adjuvants” to enhance the activity of certain antibiotics.

Cognitive Empathy And Longitudinal Changes In Temporo-Parietal Junction Thickness In Schizophrenia, Derin J. Cobia, Tatiana Karpouzian-Rogers, Julie Petersen, Lei Wang, Vijay A. Mittal, John G. Csernansky, Matthew J. Smith

Faculty Publications

Objective: Deficits in cognitive empathy are well-documented in individuals with schizophrenia and are related to reduced community functioning. The temporoparietal junction (TPJ) is closely linked to cognitive empathy. We compared the relationship between baseline cognitive empathy and changes in TPJ thickness over 24 months between individuals with schizophrenia and healthy controls. Methods: Individuals with schizophrenia (n = 29) and healthy controls (n = 26) completed a cognitive empathy task and underwent structural neuroimaging at baseline and approximately 24 months later. Symmetrized percent change scores were calculated for right and left TPJ, as well as whole-brain volume, and compared between groups. …

Prion-Like C-Terminal Domain Of Tdp-43 And Α-Synuclein Interact Synergistically To Generate Neurotoxic Hybrid Fibrils, Shailendra Dhakal, Courtney E. Wyant, Hannah E. George, Sarah E. Morgan, Vijayaraghavan Rangachari

Faculty Publications

Aberrant aggregation and amyloid formation of tar DNA binding protein (TDP-43) and α-synuclein (αS) underlie frontotemporal dementia (FTD) and Parkinson’s disease (PD), respectively. Amyloid inclusions of TDP-43 and αS are also commonly co-observed in amyotrophic lateral sclerosis (ALS), dementia with Lewy bodies (DLB) and Alzheimer disease (AD). Emerging evidence from cellular and animal models show colocalization of the TDP-43 and αS aggregates, raising the possibility of direct interactions and co-aggregation between the two proteins. In this report, we set out to answer this question by investigating the interactions between αS and prion-like pathogenic C-terminal domain of TDP-43 (TDP-43 PrLD). PrLD …